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JAMA The Journal of the American Medical Association
Journal Prestige (SJR): 8.876
Citation Impact (citeScore): 7
Number of Followers: 2629  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0098-7484 - ISSN (Online) 1538-3598
Published by American Medical Association Homepage  [14 journals]
  • Audio Highlights

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      Abstract: Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2020.18241
      Issue No: Vol. 326, No. 20 (2021)
       
  • JAMA

    • Free pre-print version: Loading...

      Pages: 1995 - 1996
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2020.18239
      Issue No: Vol. 326, No. 20 (2021)
       
  • Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents

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      Authors: Slomski A.
      Pages: 1997 - 1999
      Abstract: This Medical News article describes trials that are examining whether medicinal mushrooms and Chinese herbs can improve treatment and vaccine responses against COVID-19.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19388
      Issue No: Vol. 326, No. 20 (2021)
       
  • Substance Use Disorders and COVID-19 Vaccine Response

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      Authors: Rubin R.
      Pages: 2000 - 2000
      Abstract: Among individuals fully vaccinated against COVID-19, those with substance use disorders (SUD) may have a higher risk of becoming infected with SARS-CoV-2, according to a recent study led by researchers at the National Institute on Drug Abuse and Case Western Reserve University.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19977
      Issue No: Vol. 326, No. 20 (2021)
       
  • Support for Primary Care Clinicians in Underserved Areas

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      Authors: Rubin R.
      Pages: 2000 - 2000
      Abstract: The US Department of Health and Human Services (HHS) recently announced that it will provide $100 million for state-run programs that support, recruit, and retain primary care clinicians who live and work in underserved communities.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20454
      Issue No: Vol. 326, No. 20 (2021)
       
  • The Cost of Rare Diseases

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      Authors: Rubin R.
      Pages: 2000 - 2000
      Abstract: Although research on the costs of rare diseases is limited, in part because they’re difficult to diagnose, the available evidence suggests the toll can be substantial, according to a recent Government Accountability Office (GAO) report.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20455
      Issue No: Vol. 326, No. 20 (2021)
       
  • Pembrolizumab Boosts Breast and Cervical Cancer Survival

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      Authors: Slomski A.
      Pages: 2001 - 2001
      Abstract: The anti–programmed cell death 1 (PD-1) monoclonal antibody pembrolizumab improved survival among patients with breast or cervical cancer in 2 recent phase 3 trials.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19200
      Issue No: Vol. 326, No. 20 (2021)
       
  • Daily COVID-19 Tests Compared With Isolation After School Exposure

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      Authors: Slomski A.
      Pages: 2001 - 2001
      Abstract: Daily testing of students exposed to COVID-19 at school could be a safe alternative to home isolation, a study in The Lancet suggests. The approach allows students to attend school and may reduce other negative consequences of isolating at home, according to the investigators.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20471
      Issue No: Vol. 326, No. 20 (2021)
       
  • Intensive Blood Pressure Control Lowers Cardiovascular Risk

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      Authors: Slomski A.
      Pages: 2001 - 2001
      Abstract: Older patients with hypertension had fewer cardiovascular events when they received intensive treatment targeting a lower systolic blood pressure target in the STEP (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) trial.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20472
      Issue No: Vol. 326, No. 20 (2021)
       
  • Virtual Care Mitigates Pain and Drug Errors After Surgery

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      Authors: Slomski A.
      Pages: 2001 - 2001
      Abstract: In a trial conducted during the COVID-19 pandemic, virtual care with remote automated monitoring (RAM) increased drug error detection and correction and decreased pain among patients discharged home after nonelective surgery. However, virtual care did not affect days alive at home following discharge compared with standard care.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20473
      Issue No: Vol. 326, No. 20 (2021)
       
  • COVID-19 Vaccine Highly Effective Against Adolescent Hospitalizations

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      Authors: Kuehn BM.
      Pages: 2002 - 2002
      Abstract: Two doses of the BNT162b2 (Pfizer-BioNTech) vaccine were 93% effective against adolescent hospitalization for COVID-19, a case-control study at 19 pediatric hospitals in 16 states showed.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20143
      Issue No: Vol. 326, No. 20 (2021)
       
  • Unhygienic Practices Lead to Routine Vaccination-Linked Infections

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      Authors: Kuehn BM.
      Pages: 2002 - 2002
      Abstract: Poor practices at a third-party health care company hired in 2018 to provide routine workplace vaccinations in 3 states led to 101 vaccine-associated adverse events, an investigation by the CDC and state public health authorities found.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20171
      Issue No: Vol. 326, No. 20 (2021)
       
  • New Clinical Trial Grants for Rare Diseases

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      Authors: Rubin R.
      Pages: 2003 - 2003
      Abstract: A painful, potentially life-threatening skin disease, an inherited disease that can cause long-term brain development issues, and pediatric brain cancer are among the rare diseases for which the US Food and Drug Administration has awarded 11 new clinical trial research grants.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20256
      Issue No: Vol. 326, No. 20 (2021)
       
  • First Thymus Tissue Product Approved for Rare Disease

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      Authors: Rubin R.
      Pages: 2003 - 2003
      Abstract: The FDA recently approved the first thymus tissue product as a 1-time treatment of congenital athymia, an ultrarare immune disorder in which children are born without a thymus.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20538
      Issue No: Vol. 326, No. 20 (2021)
       
  • Compounded Drug Guidance for Hospital and Health System Pharmacies

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      Authors: Rubin R.
      Pages: 2003 - 2003
      Abstract: Some hospitalized patients’ medical needs can’t be met by an approved drug, so in 2016 the US Food and Drug Administration (FDA) issued a draft guidance about drug compounding. The agency recently revised the draft guidance, which contains nonbinding recommendations.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20539
      Issue No: Vol. 326, No. 20 (2021)
       
  • The Self-directed Medical Student Curriculum

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      Authors: Wu JH; Gruppuso PA, Adashi EY.
      Pages: 2005 - 2006
      Abstract: This Viewpoint discusses the growing role of medical students in shaping their own education and outlines the measures needed to ensure that medical student–directed learning remains aligned with the educational aims of the medical discipline.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16312
      Issue No: Vol. 326, No. 20 (2021)
       
  • Contraception Requirements in Clinical Trials

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      Authors: Balkus JE; Dionne-Odom J, Wiesenfeld HC.
      Pages: 2007 - 2008
      Abstract: This Viewpoint proposes a risk-based approach toward contraception use in clinical trials of investigational products, which could improve access and inclusivity for individuals with pregnancy potential who are at risk for the outcomes of interest.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19473
      Issue No: Vol. 326, No. 20 (2021)
       
  • Twenty Years After the Anthrax Terrorist Attacks: Lessons Learned and
           Unlearned for COVID-19

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      Authors: Gostin LO; Nuzzo JB.
      Pages: 2009 - 2010
      Abstract: This Viewpoint discusses the public health emergency preparedness response strategies instituted in the US after the anthrax attacks of 2001 in the context of the gaps in public health readiness that were exposed by the COVID-19 pandemic.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19292
      Issue No: Vol. 326, No. 20 (2021)
       
  • Taking Down the Shingle

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      Authors: Roston D.
      Pages: 2011 - 2011
      Abstract: In this narrative medicine essay, a psychiatrist reflects on the lasting effects of her practice after it closes, understanding that its memory will be preserved by her patients.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20106
      Issue No: Vol. 326, No. 20 (2021)
       
  • Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis

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      Authors: Katz JN.
      Pages: 2012 - 2014
      Abstract: Symptomatic, radiographically documented knee osteoarthritis (OA) affects more than 14 million adults in the US and approximately 240 million worldwide, while symptomatic, radiographically documented ankle OA has been estimated to affect 3.4% of persons older than 50 years (approximately 3 million to 4 million adults older than 50 years in the US). Ankle OA develops typically in response to trauma (eg, fracture) and therefore often affects people in their active working years. Achilles tendinitis has an incidence estimated of approximately 2 per 1000 in the Netherlands and is associated with Achilles tendon rupture, an extremely disabling condition. These 3 conditions: knee OA, ankle OA, and Achilles tendinopathy, are costly and disabling, yet few effective therapies are available that relieve pain and also reverse underlying tissue damage.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19540
      Issue No: Vol. 326, No. 20 (2021)
       
  • Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic
           Steatohepatitis

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      Authors: Corey KE; Memel Z.
      Pages: 2015 - 2017
      Abstract: Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is the leading cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH) represents the progressive form of NAFLD, in which steatosis is accompanied by inflammation and fibrosis that can lead to cirrhosis. Despite the increasing prevalence of NASH and NASH cirrhosis, there are no Food and Drug Administration (FDA)–approved pharmacotherapies that reduce liver-related outcomes in patients with NASH. In liver disease, the progression of fibrosis to cirrhosis and the development of decompensation, including hepatic encephalopathy, variceal hemorrhage, and ascites, occur over decades and randomized clinical trials are not well-equipped to evaluate these outcomes. Thus, evaluation of potentially effective therapies to prevent liver-related events requires novel study designs.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.17451
      Issue No: Vol. 326, No. 20 (2021)
       
  • Understanding Breakthrough Infections Following mRNA SARS-CoV-2
           Vaccination

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      Authors: Klompas M.
      Pages: 2018 - 2020
      Abstract: The current surge in infections with the SARS-CoV-2 Delta variant has made it clear to health care workers and the public alike that fully vaccinated people remain at risk for SARS-CoV-2 infections. It is also apparent that breakthrough infections in fully vaccinated people can sometimes be serious. As of October 21, 2021, for example, 35% of the 519 patients hospitalized with COVID-19 in Massachusetts had been fully vaccinated. Furthermore, multiple reports have documented that if fully vaccinated individuals do become infected, their viral loads may be as high as the levels seen in unvaccinated individuals. In July 2021, these observations led the US Centers for Disease Control and Prevention to modify its guidance for fully vaccinated people, advising that those in communities with substantial or high SARS-CoV-2 transmission rates should wear masks indoors regardless of their vaccination status. A wealth of new data has since emerged that is helping to deepen understanding of the frequency, severity, and importance of breakthrough infections in fully vaccinated individuals.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19063
      Issue No: Vol. 326, No. 20 (2021)
       
  • Effect of Intra-articular Platelet-Rich Plasma vs Placebo on Pain and
           Cartilage Volume in Knee Osteoarthritis

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      Authors: Bennell KL; Paterson KL, Metcalf BR, et al.
      Pages: 2021 - 2030
      Abstract: This randomized trial assesses the effect of injections of platelet-rich plasma vs saline placebo on 12-month changes in knee pain scores and medial tibial cartilage volume among patients with symptomatic mild to moderate knee osteoarthritis.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19415
      Issue No: Vol. 326, No. 20 (2021)
       
  • Association of Bariatric Surgery With Adverse Outcomes in Patients With
           Nonalcoholic Steatohepatitis

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      Authors: Aminian A; Al-Kurd A, Wilson R, et al.
      Pages: 2031 - 2042
      Abstract: This cohort study investigates the association between bariatric surgery and incident major adverse liver outcomes and major adverse cardiovascular events in patients with obesity and biopsy-proven fibrotic NASH without cirrhosis.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19569
      Issue No: Vol. 326, No. 20 (2021)
       
  • Association of COVID-19 mRNA Vaccination With Hospitalizations and Disease
           Severity

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      Authors: Tenforde MW; Self WH, Adams K, et al.
      Pages: 2043 - 2054
      Abstract: This case-control study explores the association between vaccination with mRNA COVID-19 vaccines and hospitalization for COVID-19, and, among patients hospitalized with COVID-19, the association with progression to critical disease in adults from 18 US states.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19499
      Issue No: Vol. 326, No. 20 (2021)
       
  • Management of Acne Vulgaris

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      Authors: Eichenfield DZ; Sprague J, Eichenfield LF.
      Pages: 2055 - 2067
      Abstract: This review summarizes the characteristics of comedonal, inflammatory, and nodulocystic acne and describes current methods of treatment.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.17633
      Issue No: Vol. 326, No. 20 (2021)
       
  • Use of Confidence Intervals in Interpreting Nonstatistically Significant
           Results

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      Authors: Hawkins AT; Samuels LR.
      Pages: 2068 - 2069
      Abstract: This Guide to Statistics and Methods describes how confidence intervals can be used to help in the interpretation of nonsignificant findings across all study designs.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16172
      Issue No: Vol. 326, No. 20 (2021)
       
  • Back Pain, Fever, and Cough in a 46-Year-Old Man

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      Authors: Richterman A; Richard-Greenblatt M, Whitaker K.
      Pages: 2070 - 2071
      Abstract: A 46-year-old man with a history of travel to India had 3 months of upper back pain and 2 weeks of dry cough and subjective fevers that did not improve with empirical azithromycin. Chest CT showed a dense consolidation in the left lower lobe; MRI showed a paraspinal mass with extensive contrast enhancement in the lower thoracic vertebral bodies and relative sparing of the disks. What is the diagnosis and what would you do next'
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.17584
      Issue No: Vol. 326, No. 20 (2021)
       
  • Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years,
           1976-2018

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      Authors: Ellison-Barnes A; Johnson S, Gudzune K.
      Pages: 2073 - 2074
      Abstract: This study uses nationally representative data from the National Health and Nutrition Examination Survey to examine changes in obesity prevalence in the US over the last 4 decades among adults aged 18 through 25 years.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16685
      Issue No: Vol. 326, No. 20 (2021)
       
  • Incidence of Pancreatic Cancer by Age and Sex in the US

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      Authors: Gaddam S; Abboud Y, Oh J, et al.
      Pages: 2075 - 2077
      Abstract: This study uses data from the Surveillance Epidemiology and End Results database to perform an age- and sex-specific time trend analysis of pancreatic cancer incidence rates in US adults.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.18859
      Issue No: Vol. 326, No. 20 (2021)
       
  • Risk of N -Nitrosodimethylamine (NMDA) Formation With Ranitidine

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      Authors: Strauss DG; Florian J, Keire D.
      Pages: 2077 - 2077
      Abstract: To the Editor A recent Editorial accompanying our published clinical trial in JAMA and in vitro studies in JAMA Network Open provides comments on our work that found no evidence of ranitidine converting to N-nitrosodimethylamine (NDMA) in humans. The editorial suggests that chloramine in tap water could facilitate ranitidine conversion to NDMA in humans, citing a study that assessed NDMA in chloraminated tap water 24 hours after adding ranitidine. However, NDMA was measured with high-temperature analytical methods that can produce falsely high NDMA values, and the water pH was 7.0. A follow-up study demonstrated that the chloramine-dependent reaction is highly pH dependent, with a substantially slower reaction and less NDMA formed as pH decreases. Additionally, when chloraminated water is combined with gastric fluid, chloramine disappears within 30 seconds, making chloramine-driven conversion of ranitidine to NDMA in vivo unlikely.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16261
      Issue No: Vol. 326, No. 20 (2021)
       
  • Risk of N -Nitrosodimethylamine (NMDA) Formation With
           Ranitidine—Reply

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      Authors: White C; Hernandez AV.
      Pages: 2077 - 2078
      Abstract: In Reply Our Editorial highlighted that 2 new studies in JAMA and JAMA Network Open greatly extended our understanding of NMDA production with ranitidine but also elucidated areas in which further research is needed. In their letter to the editor, Dr Strauss and colleagues provide some additional in vitro data to show that the scenarios we proposed are unlikely to increase NDMA production.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16264
      Issue No: Vol. 326, No. 20 (2021)
       
  • The Role of Lipoprotein(a) in Cardiovascular Diseases

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      Authors: Nachtigall M; Nachtigall RH.
      Pages: 2078 - 2078
      Abstract: To the Editor The recent JAMA Insights article on lipoprotein(a) and cardiovascular disease provided a concise overview of the role of lipoprotein(a) in cardiovascular disease. However, we believe that the discussion of treatment would have been enhanced by mention of estrogen as a lipoprotein(a)-lowering agent in women. A 2017 review of multiple randomized clinical studies by Anagnostis et al affirmed estrogen as a lipoprotein(a)-lowering therapy in women, supporting this treatment effect.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16747
      Issue No: Vol. 326, No. 20 (2021)
       
  • The Role of Lipoprotein(a) in Cardiovascular Diseases—Reply

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      Authors: Natarajan P; Miksenas H, Januzzi JL, Jr.
      Pages: 2078 - 2079
      Abstract: In Reply In response to our recent article about lipoprotein(a) and cardiovascular disease, Drs Nachtigall discuss estrogen as a lipoprotein(a)-lowering agent in women. Although menopausal hormone therapy has been linked to excess cardiovascular disease risks, estrogen-only hormone therapy has not been shown to increase the risk of coronary events.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16750
      Issue No: Vol. 326, No. 20 (2021)
       
  • Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary
           Tract Infection

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      Authors: Goldberg J; Powers JH, III.
      Pages: 2079 - 2079
      Abstract: To the Editor The recent study evaluating 7- vs 14-day duration of therapy for afebrile men with urinary tract infection (UTI) advanced understanding of treatment for a common ambulatory infection. However, a basic principle of clinical research is appropriate matching of research questions with study designs that evaluate those questions. As the authors stated, “extended therapy often does not provide additional benefit” on patient outcomes. The study design to address this question would use a superiority hypothesis with randomization after initial symptom recovery. In contrast, this study, as in others, used a noninferiority hypothesis, allowing up to 10% lesser efficacy with placebo compared with 7 additional days of drug therapy when patients are randomized after 7 days of initial therapy. This trial design addresses a different research question and raises challenges in scientific validity as well as differing trial conclusions.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16735
      Issue No: Vol. 326, No. 20 (2021)
       
  • Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary
           Tract Infection

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      Authors: Yap S.
      Pages: 2079 - 2080
      Abstract: To the Editor I have several concerns about the conclusion of a recent article that 7 days of antibiotic treatment in afebrile men with UTI was noninferior to 14 days. First, diagnosis of uncomplicated UTI in men is not always straightforward. The eligibility criteria of this study were largely dependent on a clinician’s impression of the cause of a patient’s symptom(s). However, some patients may have prostatic hypertrophy or an indwelling urinary catheter, which may cause symptoms similar to a UTI. Second, investigating antibiotic treatment for UTI requires a high level of diagnostic accuracy, including the identification of the urinary pathogen and estimation of levels of pretreatment bacteriuria. Antibiotic sensitivity and bacteriuria levels could confound the relationship between treatment duration and resolution of symptoms. Third, antibiotic susceptibilities may vary depending on variables such as region because of different approaches to antimicrobial stewardship and uropathogen strain. Fourth, I am concerned about the inclusion of 2 different antibiotics in the study. Uropathogenic Escherichia coli commonly exhibits lower antibiotic susceptibility to trimethoprim than do fluoroquinolones, which may result in poorer outcomes in the group treated with trimethoprim-sulfamethoxazole.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16741
      Issue No: Vol. 326, No. 20 (2021)
       
  • Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary
           Tract Infection

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      Authors: Ahmed H; Gillespie D, Thomas-Jones E.
      Pages: 2080 - 2080
      Abstract: To the Editor We have some concerns about the recent study by Dr Drekonja and colleagues. First, UK and European guidelines have recommended 7-day treatment for afebrile men with UTI since 2018, making it unlikely that the findings of this trial will change clinical practice in these countries. Second, we were surprised at the inclusion of ciprofloxacin, given warnings from the US Food and Drug Administration and other organizations. Although we acknowledge that the decision to use ciprofloxacin was made in 2014, this highlights (1) the substantial variation in treatment of UTI in men (90% treated with ciprofloxacin in the US in 2014 vs 60% in the UK) and (2) how the time taken to complete randomized trials may have adverse clinical effects. Ciprofloxacin warnings and increasing use of other antibiotics (eg, nitrofurantoin) could have prompted this trial team and its steering committee to consider whether ciprofloxacin remained an appropriate and relevant choice of antibiotic.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16738
      Issue No: Vol. 326, No. 20 (2021)
       
  • Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary
           Tract Infection—Reply

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      Authors: Drekonja DM; Trautner B, Johnson JR.
      Pages: 2080 - 2081
      Abstract: In Reply We appreciate the opportunity to respond to the issues raised in these Letters to the Editor about our study. Drs Goldberg and Powers question the choice of a noninferiority study design, arguing that a superiority approach is preferable when the benefits of additional therapy are unknown and potentially smaller than the chosen minimum clinically significant difference (10% in our study). They also call for investigators, sponsors, and scientific and ethical review boards to evaluate the use of noninferiority trials. We agree and note that this trial’s design started as a superiority trial but emerged with a noninferiority design after 3 successive rounds of Veterans Affairs scientific review. The Veterans Affairs reviewers recommended this change, noting that the bulk of the published studies of antimicrobial duration have been noninferiority trials. Because antimicrobial therapy is superior to no antimicrobial therapy for UTI, we strongly doubt that 7 and 14 days of antimicrobial therapy yielded similar outcomes because neither duration is effective.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16744
      Issue No: Vol. 326, No. 20 (2021)
       
  • Error in Box

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      Pages: 2081 - 2081
      Abstract: The Review titled “Pancreatic Cancer: A Review,” published in the September 7, 2021, issue of JAMA, included an error in the Box that indicated that polyunsaturated fats, rather than saturated fats, were a risk factor for pancreatic cancer. The Box has been corrected and indicates that saturated fats are a risk factor for pancreatic cancer. (All other information in the Box was correct and is unchanged.)
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.19984
      Issue No: Vol. 326, No. 20 (2021)
       
  • Incorrect Laboratory Value and Reference

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      Pages: 2081 - 2081
      Abstract: The Diagnostic Test Interpretation titled “Urinary Magnesium in the Evaluation of Hypomagnesemia,” published in the December 8, 2020, issue of JAMA, has been updated. In the Table, the serum albumin level has been corrected to 4.2 g/dL, and reference 4 has been corrected. This article was corrected online.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.20138
      Issue No: Vol. 326, No. 20 (2021)
       
  • first death

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      Authors: Klein J.
      Pages: 2082 - 2082
      Abstract: there was the stick, the poke, the burn, the bright red wing-and-a-prayer flourish, the vials
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16531
      Issue No: Vol. 326, No. 20 (2021)
       
  • Bacterially Tainted Money

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      Pages: 2083 - 2083
      Abstract: During the earlier years of the development of the modern science of bacteriology, the hunt for harmful microbes was a popular laboratory pastime. The readily secured evidence of the widespread distribution of germs—perhaps it should be designated the omnipresence of bacteria—at first disturbed the peace of mind of many persons who now saw the possibilities of disease transmission awaiting them at every turn. Presently, however, it became clearer that not all micro-organisms are baneful and that some are at least relatively innocuous; while the varied protective devices of the human organism against the microscopic invaders were being discovered in rapid succession, thus bringing the sense of relief that comes from the contemplation of our factors of safety.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2020.18242
      Issue No: Vol. 326, No. 20 (2021)
       
  • Patient Information: Acne Treatment

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      Authors: Chovatiya R.
      Pages: 2087 - 2087
      Abstract: This JAMA Patient Page describes acne and the various forms of treatment for this skin condition.
      PubDate: Tue, 23 Nov 2021 00:00:00 GMT
      DOI: 10.1001/jama.2021.16599
      Issue No: Vol. 326, No. 20 (2021)
       
 
JournalTOCs
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