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Journal Cover JAMA The Journal of the American Medical Association
  [SJR: 6.44]   [H-I: 549]   [1551 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0098-7484 - ISSN (Online) 1538-3598
   Published by American Medical Association Homepage  [13 journals]
  • Highlights for October 3, 2017
    • PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Digital Phenotyping
    • Authors: Insel TR.
      Abstract: In this Viewpoint, Thomas Insel discusses the possibility that sensor, keyboard, and voice and speech data from smartphones might be used as a digital phenotype to improve patient-specific measurement-based behavioral care.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Talking to Machines About Personal Mental Health Problems
    • Authors: Miner AS; Milstein A, Hancock JT.
      Abstract: This Viewpoint describes trends in the use of conversational artificial intelligence in mental health care and discusses potential advantages and risks to patients and the public.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Measuring the Cost of Quality Measurement
    • Authors: Schuster MA; Onorato SE, Meltzer DO.
      Abstract: This Viewpoint discusses the importance of accounting for the cost of measurement in establishing the value of hospital quality measures.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Author and Nonauthor Contributions in Scholarly Publications
    • Authors: Mentzelopoulos SD; Zakynthinos SG.
      Abstract: This Viewpoint discusses the importance of research authorship for academic promotion and proposes revision of research integrity codes to define nonauthor contributions and distinguish nonauthor from author contributions to discourage awarding of authorship to nonauthor collaborators.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • An OB/GYN’s Personal Story of Pregnancy Loss
    • Authors: Kelley AS.
      Abstract: It had been 1 week since I learned that our baby, at 8 weeks’ gestation, no longer had a heartbeat.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Trying to Improve Sepsis Care in Low-Resource Settings
    • Authors: Machado FR; Angus DC.
      Abstract: Earlier this year, the World Health Organization recognized sepsis as a global health problem, responsible for millions of preventable deaths every year, and adopted a resolution targeting the prevention, diagnosis, and treatment of sepsis, especially in low- and middle-income countries. Although most sepsis cases are assumed to occur in low- and middle-income countries, nearly all research on both the epidemiology of sepsis and optimal treatment comes from high-income countries.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Counting Sepsis, an Imprecise but Improving Science
    • Authors: Rudd KE; Delaney A, Finfer S.
      Abstract: Sepsis, most succinctly defined as organ dysfunction due to infection, is estimated to account for more than 5 million deaths around the world each year and to cause or contribute to approximately half of all deaths occurring in hospitals in the United States. A 2016 report from the Healthcare Cost and Utilization Project estimated the cost of treating sepsis in US hospitals in 2013 at $24 billion, making it the most expensive condition treated in US hospitals among all payers. In recent years, the substantial burden of sepsis at the individual, health system, and societal levels has become increasingly recognized by the medical community and the public, culminating in the World Health Organization (WHO) adopting the Improving the Prevention, Diagnosis, and Management of Sepsis resolution at the World Health Assembly in May 2017.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Announcing JAMA Network Open —A New Journal From The JAMA Network
    • Authors: Rivara FP; Easley TJ, Flanagin A, et al.
      Abstract: We are pleased to announce that in early 2018, The JAMA Network will launch a new journal—JAMA Network Open. Our editorial goal is to publish the very best clinical research across all disciplines, serving the worldwide community of investigators and clinicians and meeting the evolving needs and requirements of authors and funders. With the launch of JAMA Network Open, we simultaneously assert our editorial commitment to excellence and to the authorship community regardless of requirements of funders. This will be a fully open access journal and follows the launch of JAMA Oncology in 2015 and JAMA Cardiology in 2016, which are hybrid journals offering open access options for research articles. Frederick P. Rivara, MD, MPH, current editor in chief of JAMA Pediatrics, will be the editor in chief of JAMA Network Open.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Effects of an Early Resuscitation Protocol on Sepsis Mortality in Zambia
    • Authors: Andrews B; Semler MW, Muchemwa L, et al.
      Abstract: This randomized clinical trial compares the effects of an early resuscitation sepsis protocol (administration of intravenous fluids, vasopressors, and blood transfusion) vs usual care for prevention of in-hospital mortality among adults with sepsis and hypotension in Zambia.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Incidence and Trends of Sepsis in US Hospitals, 2009-2014
    • Authors: Rhee C; Dantes R, Epstein L, et al.
      Abstract: This cohort study compares estimates of sepsis incidence, outcomes, and trends based on clinical data from US hospital electronic health record systems vs claims-based ICD-9 data.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Bleeding Risk in Nonvalvular AF on NOACs With vs Without Other Medications
    • Authors: Chang S; Chou I, Yeh Y, et al.
      Abstract: This cohort study uses data from the Taiwan National Health Insurance database to assess the association between use of non–vitamin K oral anticoagulants with vs without concurrent medications and risk of major bleeding in patients with nonvalvular atrial fibrillation.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Antithrombotic Medication Use and Hematuria-Related Complications
    • Authors: Wallis CD; Juvet T, Lee Y, et al.
      Abstract: This population-based study characterize rates of hematuria-related complications among patients taking antithrombotic medications.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Cancer DNA in the Circulation
    • Authors: Husain H; Velculescu VE.
      Abstract: This JAMA Insights article explains cell-free circulating tumor DNA and its utility in noninvasive cancer detection and characterization, prediction of treatment response, monitoring of disease relapse, and identification of mechanisms of resistance to targeted therapies.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • LABA Combination Treatment for Patients With Stable Chronic Obstructive
           Pulmonary Disease
    • Authors: Horita N; Nagashima A, Kaneko T.
      Abstract: This Clinical Evidence Synopsis summarizes a Cochrane review on the efficacy of long-acting β-agonists (LABAs) combined with long-acting muscarinic antagonists vs LABAs combined with inhaled corticosteroids for patients with stable chronic obstructive pulmonary disease.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Urinalysis in the Evaluation of Proliferative Glomerulonephritis
    • Authors: Harel Z; Simel DL, Wald R.
      Abstract: A 62-year-old woman with hypertension and who had a urinary tract infection with hematuria 1 year ago presented with elevated serum creatinine. Her urinalysis was positive for hematuria, red blood cell casts, and proteinuria. How do you interpret the test results'
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Incidence of Measles in the United States, 2001-2015
    • Authors: Clemmons NS; Wallace GS, Patel M, et al.
      Abstract: This study uses Centers for Disease Control and Prevention data to characterize trends in the incidence of measles among US residents from 2001 to 2015.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Ferric Carboxymaltose to Treat Isovolemic Anemia
    • Authors: Yu Z; Li T.
      Abstract: To the Editor In a randomized clinical trial, Dr Kim and colleagues found that among adults with isovolemic anemia following radical gastrectomy, ferric carboxymaltose compared with placebo resulted in improved hemoglobin response at 12 weeks. We are concerned about the uncertain internal validity and selective outcome reporting in the article.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Ferric Carboxymaltose to Treat Isovolemic Anemia—Reply
    • Authors: Kim Y; Yang H.
      Abstract: In Reply Drs Yu and Li were concerned that the results of the Ferric Carboxymaltose for Acute Isovolemic Anemia Following Gastrectomy (FAIRY) trial may have been skewed because patients with other causes of anemia were not excluded. Limited data on the reversal of certain types of anemia (such as sickle cell and HIV/AIDS-induced anemias) with intravenous iron demonstrate the importance of excluding such patient populations. However, 3 points ameliorate this concern. First, the exclusion criteria did eliminate patients with anemia induced by chronic, inherited, or severe conditions. Among other specifications, patients with concurrent medical conditions that jeopardized health, active infection or inflammation, or an American Society of Anesthesiologist (ASA) score greater than 3 were excluded from the study. Second, the prevalence of other anemia types that may have been overlooked by the exclusion criteria is small and should have been distributed equally in both groups. A study that evaluated the incidence and etiology of postgastrectomy anemia in 161 patients with gastric cancer found that non–iron-related causes of anemia—such as megaloblastic and vitamin B12 deficiency anemias—were rare.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Different Iron Preparations for Young Children With Iron-Deficiency Anemia
    • Authors: Fujita T.
      Abstract: To the Editor In a randomized clinical trial comparing the efficacy of different iron drops containing the same amounts of essential iron for infants and young children (aged 9-48 months) with nutritional iron-deficiency anemia (IDA), ferrous sulfate drops increased mean hemoglobin concentration by 4.0 g/dL during the study period of 12 weeks compared with 3.4 g/dL with iron polysaccharide complex drops (difference, 1.0 g/dL; 95% CI, 0.4-1.6 g/dL). Consequently, Dr Powers and colleagues recommended ferrous sulfate as the first-line treatment for IDA among infants and young children.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Different Iron Preparations for Young Children With Iron-Deficiency
           Anemia—Reply
    • Authors: Powers JM; Buchanan GR, McCavit TL.
      Abstract: In Reply Dr Fujita correctly notes that infants and young children treated with ferrous sulfate in the trial had the most rapid change in hemoglobin concentration within the first 4 weeks of therapy initiation. Based on the similar rate of change in hemoglobin concentration thereafter (4-12 weeks), the suggestion was made that iron polysaccharide complex may be as efficacious as ferrous sulfate in patients with mild cases of IDA. However, an analysis of patients with mild IDA in the study does not support this conclusion.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Nonpharmacologic Treatments for Depression in Older Adults
    • Authors: Gitlin LN; Aravena JM.
      Abstract: To the Editor In their review article, Drs Kok and Reynolds discussed the clinical challenge of treating late-life depression. They provided an exhaustive analysis of pharmacological treatments, including dosing, intensity, harmful effects, target populations, and clinical significance and offered useful clinical information and directions for future research. However, their analysis of other treatments lacked depth and they missed an important opportunity to provide readers an understanding of the full range of proven approaches for addressing late-life depression.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Nonpharmacologic Treatments for Depression in Older Adults
    • Authors: Kok RM; Reynolds CF, III.
      Abstract: In Reply We agree with Dr Gitlin and Mr Aravena concerning the importance of placing late-life depression within a psychosocial context. We mentioned in our review that “recent life events, coping with functional impairment, or having a lack of social contacts are examples of psychosocial factors that are frequent contributors to depression among older adults and should be addressed as part of treatment planning.”
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Incorrect Data in the Statistical Methods Section
    • Abstract: In the Rational Clinical Examination article entitled “Does This Child Have Pneumonia' The Rational Clinical Examination Systematic Review” published in the August 1, 2017, issue of JAMA, incorrect data were reported in the Statistical Methods section. In the first paragraph of the section, the sentence should have read “From a pragmatic standpoint, at a pretest probability of 20%, the presence of a finding with an LR equal to 2 would increase the probability to 33%, and the absence of a finding with an LR equal to 0.5 would decrease the probability to 11%.” Additionally, the first sentence of the Findings section in Key Points should have read “In this systematic review and meta-analysis, the presence of hypoxia and increased work of breathing (grunting, nasal flaring, and retractions) were associated with the diagnosis of pneumonia.” This article was corrected online.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Increasing Interest in Male Contraceptives
    • Authors: Rubin R.
      Abstract: This Medical News article discusses current efforts and obstacles in developing male contraceptives.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Brain Imaging in Infants May Help Predict Autism
    • Authors: Hampton T.
      Abstract: Infants at high familial risk of autism spectrum disorder (ASD) do not typically exhibit symptoms in their first year of life, but new research indicates that magnetic resonance imaging (MRI) may reveal signs of the disorder during this presymptomatic period. The findings point to a noninvasive method to detect autism at its earliest stages, when interventions may provide the most benefits.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Our Next Health Care Debate
    • Authors: Slavitt A.
      Abstract: It’s a perfect time to reflect on the national health policy debate over coverage. Not the one we’re having now, but the one we are destined to have sometime in the 2020s. Going back at least as far as Medicare and Medicaid in the 1960s, once a decade or so, we contemplate major national coverage reforms to the US health care system. While enthusiasm builds in some circles that the next debate has the potential to bring us full universal coverage, the lessons of our recent efforts tell us we often come away with far less than we should.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Combination Drug Approved for Gout
    • Authors: Voelker R.
      Abstract: The first combination treatment for patients with hyperuricemia associated with gout has received FDA approval. Specifically, the new medication is indicated for patients who haven’t achieved target serum uric acid levels with allopurinol alone.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • New Tool to Aid Zika Diagnostics
    • Authors: Voelker R.
      Abstract: Diagnostic test manufacturers can now use human plasma samples to evaluate the accuracy of their tests to detect Zika virus infection.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Targeted Therapy for Adult Leukemia
    • Authors: Voelker R.
      Abstract: Adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) have a new FDA-approved treatment option.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • A Terrible Beauty
    • Authors: Halberstadt C.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • The Changing Concepts in Pathology
    • Abstract: Pathology as defined by Welch is “the science, as distinguished from the practice, of medicine. In a narrower and more restricted sense pathology is a study of the structural alterations produced by the disease, as revealed at postmortem examinations and during surgical operations. Pathologic anatomy is a study of these alterations, but the symptoms and the activities of the body resulting from these morbid changes belong also to pathology.”
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • Laparoscopic Groin Hernia Repair
    • Authors: Hewitt D; Chojnacki K.
      PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
  • JAMA
    • PubDate: Tue, 03 Oct 2017 00:00:00 GMT
       
 
 
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