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JCO Precision Oncology
Number of Followers: 8  
 
  Full-text available via subscription Subscription journal
ISSN (Online) 2473-4284
Published by LWW Wolters Kluwer Homepage  [297 journals]
  • Targeting Anaplastic Lymphoma Kinase in GI Primary Malignancies

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      Authors: Jerold Loh, Yvonne Li En Ang, Amit Jain, Joe Yeong, Raghav Sundar
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-08-08T07:00:00
      DOI: 10.1200/PO.22.00208
       
  • Soft Tissue Leiomyosarcoma With Microsatellite Instability, High Tumor
           Mutational Burden, and Programmed Death Ligand-1 Expression Showing
           Pathologic Complete Response to Pembrolizumab: A Case Report

         This is an Open Access Article Open Access Article

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      Authors: Timothy Kwang Yong Tay, Joe Poh Sheng Yeong, Eileen Xueqin Chen, Xin Xiu Sam, Johnathan Xiande Lim, Jason Yongsheng Chan
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-08-08T07:00:00
      DOI: 10.1200/PO.22.00068
       
  • Multianalyte Prognostic Signature Including Circulating Tumor DNA and
           Circulating Tumor Cells in Patients With Advanced Pancreatic
           Adenocarcinoma

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      Authors: William J. Chapin, Jacob E. Till, Wei-Ting Hwang, Jennifer R. Eads, Thomas B. Karasic, Peter J. O'Dwyer, Charles J. Schneider, Ursina R. Teitelbaum, Janae Romeo, Taylor A. Black, Theresa E. Christensen, Colleen Redlinger Tabery, Amanda Anderson, Megan Slade, Michael LaRiviere, Stephanie S. Yee, Kim A. Reiss, Mark H. O'Hara, Erica L. Carpenter
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-08-08T07:00:00
      DOI: 10.1200/PO.22.00060
       
  • Phase II Study of Afatinib in Patients With Tumors With Human Epidermal
           Growth Factor Receptor 2–Activating Mutations: Results From the National
           Cancer Institute–Molecular Analysis for Therapy Choice ECOG-ACRIN Trial
           (EAY131) Subprotocol EAY131-B

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      Authors: Philippe L. Bedard, Shuli Li, Kari B. Wisinski, Eddy S. Yang, Sewanti A. Limaye, Edith P. Mitchell, James A. Zwiebel, Jeffrey A. Moscow, Robert J. Gray, Victoria Wang, Lisa M. McShane, Larry V. Rubinstein, David R. Patton, P. Mickey Williams, Stanley R. Hamilton, Barbara A. Conley, Carlos L. Arteaga, Lyndsay N. Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-08-08T07:00:00
      DOI: 10.1200/PO.22.00165
       
  • An Approach to Solving the Complex Clinicogenomic Data Landscape in
           Precision Oncology: Learnings From the Design of WAYFIND-R, a Global
           Precision Oncology Registry

         This is an Open Access Article Open Access Article

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      Authors: Christophe Le Tourneau, Camille Perret, Allan Hackshaw, Jean-Yves Blay, Christoph Nabholz, Jan Geissler, Thy Do, Martina von Meyenn, Rodrigo Dienstmann
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-08-08T07:00:00
      DOI: 10.1200/PO.22.00019
       
  • Response to Alpelisib in an Adolescent With PIK3CA-Mutated Metastatic
           Gastrointestinal Stromal Tumor

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      Authors: Sarah Cohen-Gogo, Nisha Kanwar, Furqan Shaikh, Reto M. Baertschiger, Adam Shlien, David Malkin, Juan Putra, Ailish Coblentz, Anita Villani, Abha A. Gupta, Daniel A. Morgenstern
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-08-02T07:00:00
      DOI: 10.1200/PO.22.00105
       
  • Lung Adenocarcinoma Associated With Germline EGFR R776H Variant: A Case
           Report and Review of the Literature

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      Authors: Justin Lin Sovich, Tu Dan, Amber Gemmell, Cheyla Clark, Jeffrey Gagan, Jonathan E. Dowell
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-21T07:00:00
      DOI: 10.1200/PO.21.00559
       
  • Identification of KRASG12C Mutations in Circulating Tumor DNA in Patients
           With Cancer

         This is an Open Access Article Open Access Article

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      Authors: Kyaw Z. Thein, Amadeo B. Biter, Kimberly C. Banks, Andrew W. Duda, Jennifer Saam, Jason Roszik, Filip Janku, Ferdinandos Skoulidis, John V. Heymach, Scott Kopetz, Funda Meric-Bernstam, David S. Hong
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-07-21T07:00:00
      DOI: 10.1200/PO.21.00547
       
  • DPYD*7 as a Predictor of Severe Fluoropyrimidine-Related Adverse Events

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      Authors: Mirjam de With, Gemma Brufau, Laila A. van den Berg, Femke M. de Man, Marija Trajkovic, Martine F. Thijs, Rob Castel, Henricus J. Vermeer, Samira el Bouazzaoui, Amber van Hemel, Maja Matic, Ron H. J. Mathijssen, Sander Bins, Ron H. N. van Schaik
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-07-21T07:00:00
      DOI: 10.1200/PO.22.00180
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-18T07:00:00
      DOI: 10.1200/PO.22.00356
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-18T07:00:00
      DOI: 10.1200/PO.22.00354
       
  • BRCA2 Alterations in Neuroendocrine/Small-Cell Carcinoma Prostate Cancer:
           A Case Series

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      Authors: Lynn Symonds, Erik Konnick, Funda Vakar-Lopez, Heather H. Cheng, Michael T. Schweizer, Peter S. Nelson, Colin C. Pritchard, Bruce Montgomery
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-14T07:00:00
      DOI: 10.1200/PO.22.00091
       
  • Longitudinal Monitoring of Circulating Tumor DNA to Predict Treatment
           Outcomes in Advanced Cancers

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      Authors: Mohamed A. Gouda, Helen J. Huang, Sarina A. Piha-Paul, S. Greg Call, Daniel D. Karp, Siqing Fu, Aung Naing, Vivek Subbiah, Shubham Pant, Derek J. Dustin, Apostolia M. Tsimberidou, David S. Hong, Jordi Rodon, Funda Meric-Bernstam, Filip Janku
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-07-14T07:00:00
      DOI: 10.1200/PO.21.00512
       
  • Cost-Effectiveness of Parallel Versus Sequential Testing of Genetic
           Aberrations for Stage IV Non–Small-Cell Lung Cancer in the Netherlands

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      Authors: Henri B. Wolff, Elisabeth M.P. Steeghs, Zakile A. Mfumbilwa, Harry J.M. Groen, Eddy M. Adang, Stefan M. Willems, Katrien Grünberg, Ed Schuuring, Marjolijn J.L. Ligtenberg, Bastiaan B.J. Tops, Veerle M.H. Coupé
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-07-14T07:00:00
      DOI: 10.1200/PO.22.00201
       
  • Spontaneous Fluctuations of Tumor-Informed Circulating Tumor DNA at Low
           Levels

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      Authors: Farshid Dayyani, Maheswari Senthil
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-14T07:00:00
      DOI: 10.1200/PO.22.00177
       
  • Reply to F. Dayyani et al

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      Authors: Pashtoon M. Kasi, Gordon Fehringer, Alexey Aleshin, Scott Kopetz
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-14T07:00:00
      DOI: 10.1200/PO.22.00275
       
  • CDK4/6 Inhibition With Anti–PD-1 Checkpoint Blockade Induces Major
           Response in Aggressive Classic Kaposi Sarcoma After Previous Progression
           on Anti-PD–1 Alone

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      Authors: Sminu Bose, Tristan Lee, Shaelyn Choi, Ladan Fazlollahi, Michael J. Rasiej, Gary K. Schwartz, Matthew Ingham
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-12T07:00:00
      DOI: 10.1200/PO.21.00550
       
  • Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in
           Metastatic Prostate Cancer Following Progression on Androgen-Targeting
           Therapies

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      Authors: Amado J. Zurita, Ryon P. Graf, Guillermo Villacampa, Kira Raskina, Ethan Sokol, Dexter Jin, Emmanuel S. Antonarakis, Gerald Li, Richard S. P. Huang, Irene Casanova-Salas, Ana Vivancos, Joan Carles, Jeffrey S. Ross, Alexa B. Schrock, Geoffrey R. Oxnard, Joaquin Mateo
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-07-12T07:00:00
      DOI: 10.1200/PO.22.00195
       
  • Germline De Novo Mutations as a Cause of Childhood Cancer

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      Authors: Wafaa M. Rashed, Erin L. Marcotte, Logan G. Spector
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Cancer Prevention
      Citation: JCO Precision Oncology
      PubDate: |2022-07-12T07:00:00
      DOI: 10.1200/PO.21.00505
       
  • DICER1-Associated Anaplastic Sarcoma of the Kidney With Coexisting
           Activating PDGFRA D842V Mutations and Response to Targeted Kinase
           Inhibitors in One Patient

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      Authors: Cristina R. Antonescu, Victor E. Reuter, Mary Lou Keohan, Sinchun Hwang, Ping Chi
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-07T07:00:00
      DOI: 10.1200/PO.21.00554
       
  • Durable Response to Combined Osimertinib and Pralsetinib Treatment for
           Osimertinib Resistance Due to Novel Intergenic ANK3-RET Fusion in
           EGFR-Mutated Non–Small-Cell Lung Cancer

         This is an Open Access Article Open Access Article

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      Authors: Edyta M. Urbanska, Jens B. Sørensen, Linea C. Melchior, Junia C. Costa, Eric Santoni-Rugiu
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-07-07T07:00:00
      DOI: 10.1200/PO.22.00040
       
  • Matched Molecular Profiling of Cell-Free DNA and Tumor Tissue in Patients
           With Advanced Clear Cell Renal Cell Carcinoma

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      Authors: Ritesh R. Kotecha, Erika Gedvilaite, Ryan Ptashkin, Andrea Knezevic, Samuel Murray, Ian Johnson, Natalie Shapnik, Darren R. Feldman, Maria I. Carlo, Neil J. Shah, Marisa Dunigan, Kety Huberman, Ryma Benayed, Ahmet Zehir, Michael F. Berger, Marc Ladanyi, Dana W. Y. Tsui, Robert J. Motzer, Chung-Han Lee, Martin H. Voss
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-07-07T07:00:00
      DOI: 10.1200/PO.22.00012
       
  • Multidimensional Molecular Profiling of Metastatic Triple-Negative Breast
           Cancer and Immune Checkpoint Inhibitor Benefit

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      Authors: Romualdo Barroso-Sousa, Juliet Forman, Katharine Collier, Zachary T. Weber, Tejas R. Jammihal, Katrina Z. Kao, Edward T. Richardson, Tanya Keenan, Ofir Cohen, Michael P. Manos, Ryan C. Brennick, Patrick A. Ott, F. Stephen Hodi, Deborah A. Dillon, Victoria Attaya, Tess O'Meara, Nancy U. Lin, Eliezer M. Van Allen, Scott Rodig, Eric P. Winer, Elizabeth A. Mittendorf, Catherine J. Wu, Nikhil Wagle, Daniel G. Stover, Sachet A. Shukla, Sara M. Tolaney
      Abstract: JCO Precision Oncology, Volume , Issue 6, July 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-07-07T07:00:00
      DOI: 10.1200/PO.21.00413
       
  • Social Genomics as a Framework for Understanding Health Disparities Among
           Adolescent and Young Adult Cancer Survivors: A Commentary

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      Authors: Lauren V. Ghazal, Steve Cole, John M. Salsman, Lynne Wagner, Fenghai Duan, Ilana Gareen, Lauren Lux, Susan K. Parsons, Christabel Cheung, David M. Loeb, Pinki Prasad, Shira Dinner, Brad Zebrack
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-30T07:00:00
      DOI: 10.1200/PO.21.00462
       
  • Tumor Mutational Burden Is a Potential Predictive Biomarker for Response
           to Immune Checkpoint Inhibitors in Patients With Advanced Biliary Tract
           Cancer

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      Authors: Savannah S. Liddell, Sakti Chakrabarti, Grant A. Wintheiser, Tyler J. Zemla, Qian Shi, Sri Harsha Tella, Zhaohui Jin, Vanessa B. Wookey, Hind Hassan, Nguyen H. Tran, Mitesh J. Borad, Amit Mahipal
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-06-30T07:00:00
      DOI: 10.1200/PO.22.00003
       
  • PARP Inhibitor Insensitivity to BRCA1/2 Monoallelic Mutations in
           Microsatellite Instability-High Cancers

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      Authors: Ethan S. Sokol, Dexter X. Jin, Alexander Fine, Sally E. Trabucco, Sophia Maund, Garrett Frampton, Luciana Molinero, Emmanuel S. Antonarakis
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-06-30T07:00:00
      DOI: 10.1200/PO.21.00531
       
  • Genomic Landscape of Advanced Solid Tumors in Circulating Tumor DNA and
           Correlation With Tissue Sequencing: A Single Institution's Experience

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      Authors: Lorenzo Gerratana, Michael Movarek, Firas Wehbe, Neelima Katam, Devalingam Mahalingam, Jeannine Donahue, Ami Shah, Young K. Chae, Mary Mulcahy, Dean Tsarwhas, Victoria Villaflor, Aparna Kalyan, Maha Hussein, Jyoti Patel, Sunandana Chandra, Leonidas C. Platanias, William Gradishar, Massimo Cristofanilli, Amir Behdad
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-06-30T07:00:00
      DOI: 10.1200/PO.21.00289
       
  • Homologous Recombination Deficiency in Pancreatic Cancer: Poly
           (ADP-ribose) Polymerase Inhibition, Checkpoint Inhibition, or a
           Combination of Both'

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      Authors: Fergus Keane, Wungki Park, Eileen M. O'Reilly
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-30T07:00:00
      DOI: 10.1200/PO.22.00141
       
  • Reply to F. Keane et al

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      Authors: Vinod Ganju, Daniel Croagh, Joanne Lundy
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-30T07:00:00
      DOI: 10.1200/PO.22.00171
       
  • Checkpoint Inhibitor Immunotherapy to Treat Temozolomide-Associated
           Hypermutation in Advanced Atypical Carcinoid Tumor of the Lung

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      Authors: Fangdi Sun, James P. Grenert, Lisa Tan, Jessica Van Ziffle, Nancy M. Joseph, Claire K. Mulvey, Emily Bergsland
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-23T07:00:00
      DOI: 10.1200/PO.22.00009
       
  • RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal
           Adenocarcinoma

    • Free pre-print version: Loading...

      Authors: Fanfan Xie, Ding Ding, Cong Lin, Dea Cunningham, Michael Wright, Ammar A. Javed, Nilo Azad, Valerie Lee, Ross Donehower, Ana De Jesus-Acosta, Dung T. Le, Michael Pishvaian, Eun Ji Shin, Anne Marie Lennon, Mouen Khashab, Vikesh Singh, Alison P. Klein, Nicholas J. Roberts, Amy Hacker-Prietz, Thomas McPhaul, Richard A. Burkhart, William R. Burns, Amol Narang, Atif Zaheer, Elliot K. Fishman, Elizabeth D. Thompson, Robert Anders, Jun Yu, Jin He, Christopher L. Wolfgang, Lei Zheng, Dongbing Liu, Kui Wu, Daniel A. Laheru
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-06-23T07:00:00
      DOI: 10.1200/PO.21.00404
       
  • Disparities in Biomarker Testing and Clinical Trial Enrollment Among
           Patients With Lung, Breast, or Colorectal Cancers in the United States

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      Authors: Debora S. Bruno, Lisa M. Hess, Xiaohong Li, Eric Wen Su, Monaliben Patel
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Diagnostics
      Citation: JCO Precision Oncology
      PubDate: |2022-06-23T07:00:00
      DOI: 10.1200/PO.21.00427
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-23T07:00:00
      DOI: 10.1200/PO.22.00301
       
  • Gamma Secretase Inhibition for a Child With Metastatic Glomus Tumor and
           Activated NOTCH1

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      Authors: Ellen Zhang, Amber Miller, Catherine Clinton, Kylene DeSmith, Stephan D. Voss, Jon C. Aster, Alanna J. Church, Reza Rahbar, Nadezhda Eberhart, Katherine A. Janeway, Steven G. DuBois
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-22T07:00:00
      DOI: 10.1200/PO.22.00099
       
  • Clinical and Genomic Characterization of Bladder Carcinomas With Glandular
           Phenotype

    • Free pre-print version: Loading...

      Authors: Nima Almassi, Karissa Whiting, Antoun Toubaji, Andrew T. Lenis, Emmet J. Jordan, Helen Won, Ashley M. Regazzi, Ying-Bei Chen, Anuradha Gopalan, Sahussapont J. Sirintrapun, Samson W. Fine, Satish K. Tickoo, Irina Ostrovnaya, Eugene J. Pietzak, Eugene K. Cha, Alvin C. Goh, Timothy F. Donahue, Harry W. Herr, S. Machele Donat, Guido Dalbagni, Bernard H. Bochner, Min Yuen Teo, Samuel A. Funt, Jonathan E. Rosenberg, Victor E. Reuter, Dean F. Bajorin, David B. Solit, Hikmat Al-Ahmadie, Gopa Iyer
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-06-22T07:00:00
      DOI: 10.1200/PO.21.00392
       
  • Programmatic Efforts Increase Adoption of Genomic Precision Medicine in
           Cancer Care in a Community Cancer Center

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      Authors: Sourat Darabi, David Braxton, Jeanne Homer, Taylor Brodie, Dori Holnagel, Burton Eisenberg, Michael J. Demeure
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-06-22T07:00:00
      DOI: 10.1200/PO.22.00090
       
  • Missing Companion Diagnostic for US Food and Drug
           Administration–Approved Hematological and Oncological Drugs

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      Authors: Jan Trøst Jørgensen
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-16T07:00:00
      DOI: 10.1200/PO.22.00100
       
  • Locoregionally Advanced, BRAF V600L–Positive, Mucosal Melanoma of the
           Hypopharynx Treated With a Combination of BRAF and MEK Inhibitors

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      Authors: Giovanni Lampasona, Jonathan Noujaim, Olga Gologan, Jeremie Berdugo, Anastasios Maniakas
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-16T07:00:00
      DOI: 10.1200/PO.21.00561
       
  • Reply to T. Ménard

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      Authors: Nahed Jalloul, Shridar Ganesan, Judy E. Garber, Hossein Khiabanian
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-16T07:00:00
      DOI: 10.1200/PO.22.00188
       
  • Inferences of Mutational Status for Variants Detected From Tumor-Only
           Sequencing—A Quality Assurance Strategy

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      Authors: Timothé Ménard
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-16T07:00:00
      DOI: 10.1200/PO.22.00125
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-16T07:00:00
      DOI: 10.1200/PO.22.00296
       
  • A Three-Gene Signature Predicts Response to Selinexor in Multiple Myeloma

    • Free pre-print version: Loading...

      Authors: Paula Restrepo, Sherry Bhalla, Yogita Ghodke-Puranik, Adolfo Aleman, Violetta Leshchenko, David T. Melnekoff, Sarita Agte, Joy Jiang, Deepu Madduri, Joshua Richter, Shambavi Richard, Ajai Chari, Hearn Jay Cho, Sundar Jagannath, Christopher J. Walker, Yosef Landesman, Alessandro Laganà, Samir Parekh
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-06-15T07:00:00
      DOI: 10.1200/PO.22.00147
       
  • Molecular Characterization of Mesothelioma: Impact of Histologic Type and
           Site of Origin on Molecular Landscape

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      Authors: Ibiayi Dagogo-Jack, Russell W. Madison, Jochen K. Lennerz, Kuei-Ting Chen, Julia F. Hopkins, Alexa B. Schrock, Lauren L. Ritterhouse, Ashley Lester, Keith A. Wharton Jr, Mari Mino-Kenudson, Natalie Danziger, Yin P. Hung, Douglas A. Mata, Jeffrey S. Ross
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-06-15T07:00:00
      DOI: 10.1200/PO.21.00422
       
  • Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type
           2 Iodothyronine Deiodinase

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      Authors: Laura Boucai, Federico Salas-Lucia, Gnana P. Krishnamoorthy, Eric Sherman, Charles M. Rudin, Alexander Drilon, Antonio C. Bianco, James A. Fagin
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-06-15T07:00:00
      DOI: 10.1200/PO.21.00496
       
  • Minimal Residual Disease–Guided Intermittent Dosing in Patients With
           Cancer: Successful Treatment of Chemoresistant Anaplastic Large Cell
           Lymphoma Using Intermittent Lorlatinib Dosing

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      Authors: Petra Pokorna, Giannoula Lakka Klement, Alzbeta Vasikova, Veronika Kanderova, Marta Jezova, Kristyna Noskova, Peter Mudry, Michal Kyr, Tomas Merta, Viera Bajciova, Zdenka Krenova, Hana Palova, Dalibor Valik, Lenka Zdrazilova Dubska, Ondrej Slaby, Jaroslav Sterba
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-14T07:00:00
      DOI: 10.1200/PO.21.00525
       
  • Primary Clonal Loss of Mismatch Repair Protein on Immunohistochemistry: A
           Pattern of Abnormality That Warrants Genetic Workup

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      Authors: Christine Orr, Chiyun Wang, Canan Firat, Louise C. Connell, Margaret R. Sheehan, Efsevia Vakiani, Zsofia K. Stadler, Jinru Shia
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-14T07:00:00
      DOI: 10.1200/PO.22.00111
       
  • Severe Lactic Acidosis Complicated by Insulin-Resistant Hyperosmolar
           Hyperglycemic Syndrome in a Patient With Metastatic Breast Cancer
           Undergoing AKT-Inhibitor Therapy

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      Authors: Maria I. Stamou, Christopher Chen, Seth A. Wander, Jeffrey G. Supko, Dejan Juric, Aditya Bardia, Deborah J. Wexler
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-14T07:00:00
      DOI: 10.1200/PO.21.00428
       
  • MET/HGF Coexpression as a Novel Predictive Biomarker for Response to MET
           Inhibitor Therapy in a Case of Psammomatous Melanotic Schwannoma

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      Authors: Jenny J. Li, Xiaoling Zhang, Neil Sankar, Lynn Espiritu, Sanjeev Redkar, Guo-liang Yu, Sani H. Kizilbash
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-08T07:00:00
      DOI: 10.1200/PO.22.00096
       
  • Concurrent Germline BRCA1/2 and Mismatch Repair Mutations in Young-Onset
           Pancreatic and Colorectal Cancer: The Importance of Comprehensive Germline
           and Somatic Characterization to Inform Therapeutic Options

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      Authors: Muhammet Ozer, Megha Ranganathan, Nicolas Lecomte, Juan M. Schvartzman, Henry S. Walch, Walid K. Chatila, Jungeui Hong, Maria I. Carlo, Michael F. Walsh, Margaret Sheehan, Diana Mandelker, Ozge Ceyhan-Birsoy, Anna Maio, Yelena Kemel, Christine A. Iacobuzio-Donahue, Eileen M. O'Reilly, Kenneth H. Yu
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-08T07:00:00
      DOI: 10.1200/PO.21.00560
       
  • Clinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract
           Cancer Reveals Subtype-Specific Immune Signatures

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      Authors: Kabir Mody, Prerna Jain, Sherif M. El-Refai, Nilofer S. Azad, Daniel J. Zabransky, Marina Baretti, Rachna T. Shroff, R. Katie Kelley, Anthony B. El-Khouiery, Adam J. Hockenberry, Denise Lau, Gregory B. Lesinski, Mark Yarchoan
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-06-08T07:00:00
      DOI: 10.1200/PO.21.00510
       
  • Reply to E. Rosenbaum et al

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      Authors: Joseph Paul Eder
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-08T07:00:00
      DOI: 10.1200/PO.22.00136
       
  • Interpreting Nonrandomized Clinical Trial Data in Low-Grade Sarcoma:
           Differentiating Clinical Benefit From Indolent Disease Is Key

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      Authors: Evan Rosenbaum, Sujana Movva, Ciara Kelly
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-08T07:00:00
      DOI: 10.1200/PO.22.00092
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-06-08T07:00:00
      DOI: 10.1200/PO.22.00269
       
  • Germline Variant Spectrum Among African American Men Undergoing Prostate
           Cancer Germline Testing: Need for Equity in Genetic Testing

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      Authors: Veda N. Giri, Rebecca Hartman, Mary Pritzlaff, Carrie Horton, Scott W. Keith
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Cancer Genetics
      Citation: JCO Precision Oncology
      PubDate: |2022-06-06T07:00:00
      DOI: 10.1200/PO.22.00234
       
  • Cell-Free Tumor DNA Dominant Clone Allele Frequency Is Associated With
           Poor Outcomes in Advanced Biliary Cancers Treated With Platinum-Based
           Chemotherapy

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      Authors: Pedro Luiz Serrano Uson Junior, Umair Majeed, Jun Yin, Gehan Botrus, Mohamad Bassam Sonbol, Daniel H. Ahn, Jason S. Starr, Jeremy C. Jones, Hani Babiker, Samantha R. Inabinett, Natasha Wylie, Ashton W.R. Boyle, Tanios S. Bekaii-Saab, Gregory J. Gores, Rory Smoot, Michael Barrett, Bolni Nagalo, Nathalie Meurice, Natalie Elliott, Joachim Petit, Yumei Zhou, Mansi Arora, Chelsae Dumbauld, Oumar Barro, Alexander Baker, James Bogenberger, Kenneth Buetow, Aaron Mansfield, Kabir Mody, Mitesh J. Borad
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-06-06T07:00:00
      DOI: 10.1200/PO.21.00274
       
  • Longitudinal Shifts of Solid Tumor and Liquid Biopsy Sequencing
           Concordance in Metastatic Breast Cancer

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      Authors: Minetta C. Liu, Matthew MacKay, Matthew Kase, Aneta Piwowarczyk, Christine Lo, Jeff Schaeffer, Justin D. Finkle, Christopher E. Mason, Nike Beaubier, Kimberly L. Blackwell, Ben Ho Park
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-06-06T07:00:00
      DOI: 10.1200/PO.21.00321
       
  • Biomarkers for Cyclin-Dependent Kinase 4/6 Inhibitors in the Treatment of
           Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor
           2-Negative Advanced/Metastatic Breast Cancer: Translation to Clinical
           Practice

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      Authors: Tam Binh V. Bui, Boudewijn M.T. Burgering, Andrei Goga, Hope S. Rugo, Laura J. van ‘t Veer
      Abstract: JCO Precision Oncology, Volume , Issue 6, June 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-06-06T07:00:00
      DOI: 10.1200/PO.21.00473
       
  • Genomic Evolution and Personalized Therapy of an Infantile Fibrosarcoma
           Harboring an NTRK Oncogenic Fusion

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      Authors: Anne Thorwarth, Kerstin Haase, Claudia Röefzaad, Kristian W. Pajtler, Kathrin Schramm, Kathrin Hauptmann, Anke Behnke, Christian Vokuhl, Thomas Elgeti, Alexander Gratopp, Johannes H. Schulte, Monika Scheer, Pablo Hernáiz Driever, Karsten Nysom, Angelika Eggert, Anton G. Henssen, Hedwig E. Deubzer
      Abstract: JCO Precision Oncology, Volume , Issue 6, May 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-05-25T07:00:00
      DOI: 10.1200/PO.21.00283
       
  • Utility of Homologous Recombination Deficiency Biomarkers Across Cancer
           Types

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      Authors: Shiro Takamatsu, J.B. Brown, Ken Yamaguchi, Junzo Hamanishi, Koji Yamanoi, Hisamitsu Takaya, Tomoko Kaneyasu, Seiichi Mori, Masaki Mandai, Noriomi Matsumura
      Abstract: JCO Precision Oncology, Volume , Issue 6, May 2022.

      Keywords: Cancer Genetics
      Citation: JCO Precision Oncology
      PubDate: |2022-05-25T07:00:00
      DOI: 10.1200/PO.22.00085
       
  • Retraction

    • Free pre-print version: Loading...

      Abstract: JCO Precision Oncology, Volume , Issue 6, May 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-05-25T07:00:00
      DOI: 10.1200/PO.22.00124
       
  • Tumor and Constitutional Sequencing for Neurofibromatosis Type 1

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      Authors: Schuyler Tong, W. Patrick Devine, Joseph T. Shieh
      Abstract: JCO Precision Oncology, Volume , Issue 6, May 2022.

      Keywords: Cancer Genetics
      Citation: JCO Precision Oncology
      PubDate: |2022-05-18T07:00:00
      DOI: 10.1200/PO.21.00540
       
  • Clustered 8-Oxo-Guanine Mutations and Oncogenic Gene Fusions in
           Microsatellite-Unstable Colorectal Cancer

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      Authors: Russell W. Madison, Xiaoju Hu, Vivek Ramanan, Zhuxuan Xu, Richard S.P. Huang, Ethan S. Sokol, Garrett M. Frampton, Alexa B. Schrock, Siraj M. Ali, Shridar Ganesan, Subhajyoti De
      Abstract: JCO Precision Oncology, Volume , Issue 6, May 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-05-18T07:00:00
      DOI: 10.1200/PO.21.00477
       
  • Phase II Study of Lorlatinib in Patients With Anaplastic Lymphoma
           Kinase–Positive Lung Cancer and CNS-Specific Relapse

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      Authors: Ibiayi Dagogo-Jack, Geoffrey R. Oxnard, Makenzi Evangelist, Subba R. Digumarthy, Jessica J. Lin, Justin F. Gainor, John F. Murphy, Michael S. Rabin, Rebecca S. Heist, Alona Muzikansky, Alice T. Shaw
      Abstract: JCO Precision Oncology, Volume , Issue 6, May 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-05-18T07:00:00
      DOI: 10.1200/PO.21.00522
       
  • Effects of Metastatic Sites on Circulating Tumor DNA in Patients With
           Metastatic Colorectal Cancer

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      Authors: Hideaki Bando, Yoshiaki Nakamura, Hiroya Taniguchi, Manabu Shiozawa, Hisateru Yasui, Taito Esaki, Yoshinori Kagawa, Tadamichi Denda, Taroh Satoh, Kentaro Yamazaki, Yu Sunakawa, Takeshi Kato, Masahiro Goto, Satoshi Yuki, Tomohiro Nishina, Eiji Oki, Eiji Shinozaki, Nobuhisa Matsuhashi, Naoki Takahashi, Akihito Tsuji, Koushiro Ohtsubo, Masashi Wakabayashi, Takashi Ikeno, Masayuki Hata, Justin I. Odegaard, Takayuki Yoshino
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-05-11T07:00:00
      DOI: 10.1200/PO.21.00535
       
  • Negative Ultraselection of Patients With RAS/BRAF Wild-Type,
           Microsatellite-Stable Metastatic Colorectal Cancer Receiving
           Anti–EGFR-Based Therapy

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      Authors: Giovanni Randon, Giulia Maddalena, Marco Maria Germani, Chiara Carlotta Pircher, Paolo Manca, Francesca Bergamo, Mirella Giordano, Caterina Sposetti, Aldo Montagna, Guglielmo Vetere, Luca Zambelli, Cosimo Rasola, Alessandra Boccaccino, Filippo Pagani, Margherita Ambrosini, Marco Massafra, Gabriella Fontanini, Massimo Milione, Matteo Fassan, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-05-11T07:00:00
      DOI: 10.1200/PO.22.00037
       
  • Comprehensive Genomic Profiling of High-Risk Pediatric Cancer Patients Has
           a Measurable Impact on Clinical Care

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      Authors: Ryan J. Summers, Sharon M. Castellino, Christopher C. Porter, Tobey J. MacDonald, Gargi D. Basu, Szabolcs Szelinger, Manoj K. Bhasin, Thomas Cash, Alexis B. Carter, Robert Craig Castellino, Jason R. Fangusaro, Sarah G. Mitchell, Melinda G. Pauly, Bojana Pencheva, Daniel S. Wechsler, Douglas K. Graham, Kelly C. Goldsmith
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-05-11T07:00:00
      DOI: 10.1200/PO.21.00451
       
  • Progression-Free Survival in Patients With Cholangiocarcinoma With or
           Without FGF/FGFR Alterations: A FIGHT-202 Post Hoc Analysis of Prior
           Systemic Therapy Response

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      Authors: Kristen Bibeau, Luis Féliz, Christine F. Lihou, Haobo Ren, Ghassan K. Abou-Alfa
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-05-11T07:00:00
      DOI: 10.1200/PO.21.00414
       
  • Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1N546K Mutation

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      Authors: Stephen Capone, Leena Ketonen, Shiao-Pei Weathers, Vivek Subbiah
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-05-04T07:00:00
      DOI: 10.1200/PO.21.00371
       
  • Genomic Features of Lung-Recurrent Hormone-Sensitive Prostate Cancer

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      Authors: Nicolette M. Fonseca, Kim Van der Eecken, Cameron Herberts, Sofie Verbeke, Sarah W.S. Ng, Nicolaas Lumen, Elie Ritch, Andrew J. Murtha, Cecily Q. Bernales, Elena Schönlau, Lisa Moris, Jo Van Dorpe, Matti Annala, Alexander W. Wyatt, Piet Ost
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-05-04T07:00:00
      DOI: 10.1200/PO.21.00543
       
  • Isocitrate Dehydrogenase Mutations in Cholangiocarcinoma: Still a Long
           Road Ahead

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      Authors: Federico Nichetti, Monica Niger
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-05-04T07:00:00
      DOI: 10.1200/PO.22.00065
       
  • Reply to F. Nichetti et al

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      Authors: Grant Wintheiser, Tyler Zemla, Amit Mahipal
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-05-04T07:00:00
      DOI: 10.1200/PO.22.00131
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-04-28T07:00:00
      DOI: 10.1200/PO.22.00193
       
  • Distinct Neoadjuvant Chemotherapy Response and 5-Year Outcome in Patients
           With Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor
           2–Negative Breast Tumors That Reclassify as Basal-Type by the 80-Gene
           Signature

         This is an Open Access Article Open Access Article

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      Authors: Pat W. Whitworth, Peter D. Beitsch, James V. Pellicane, Paul L. Baron, Laura A. Lee, Carrie L. Dul, Mary K. Murray, Mark A. Gittleman, Raye J. Budway, Rakhshanda Layeequr Rahman, Pond R. Kelemen, William C. Dooley, David T. Rock, Kenneth H. Cowan, Beth-Ann Lesnikoski, Julie L. Barone, Andrew Y. Ashikari, Beth B. Dupree, Shiyu Wang, Andrea R. Menicucci, Erin B. Yoder, Christine Finn, Kate Corcoran, Lisa E. Blumencranz, William Audeh
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-04-27T07:00:00
      DOI: 10.1200/PO.21.00463
       
  • ALK Inhibitors in Patients With ALK Fusion–Positive GI Cancers: An
           International Data Set and a Molecular Case Series

         This is an Open Access Article Open Access Article

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      Authors: Margherita Ambrosini, Marzia Del Re, Paolo Manca, Andrew Hendifar, Alexander Drilon, Guilherme Harada, Anne Hansen Ree, Samuel Klempner, Gunhild Mari Mælandsmo, Kjersti Flatmark, Hege G. Russnes, James M. Cleary, Harshabad Singh, Elisa Sottotetti, Antonia Martinetti, Giovanni Randon, Andrea Sartore-Bianchi, Iolanda Capone, Massimo Milione, Maria Di Bartolomeo, Filippo Pietrantonio
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-04-27T07:00:00
      DOI: 10.1200/PO.22.00015
       
  • Homologous Recombination Repair Gene Variants and Outcomes Among Patients
           

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      Authors: Meghan J. Price, Vishal Vashistha, David Winski, Michael J. Kelley, Rhonda L. Bitting, Bruce Montgomery
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-04-27T07:00:00
      DOI: 10.1200/PO.21.00461
       
  • Common Variant in ALDH2 Modifies the Risk of Breast Cancer Among Carriers
           of the p.K3326* Variant in BRCA2

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      Authors: Wojciech Kluźniak, Agata Szymiczek, Amelie Rodrigue, Dominika Wokołorczyk, Bogna Rusak, Klaudia Stempa, Tomasz Huzarski, Jacek Gronwald, Jan Lubiński, Neda Zamani, Shiyu Zhang, Jean-Yves Masson, Steven A. Narod, Cezary Cybulski, Mohammad R. Akbari
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genetics
      Citation: JCO Precision Oncology
      PubDate: |2022-04-20T07:00:00
      DOI: 10.1200/PO.21.00450
       
  • Acute Leukemia Classification Using Transcriptional Profiles From Low-Cost
           Nanopore mRNA Sequencing

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      Authors: Jeremy Wang, Nickhill Bhakta, Vanessa Ayer Miller, Mahler Revsine, Mark R. Litzow, Elisabeth Paietta, Yuri Fedoriw, Kathryn G. Roberts, Zhaohui Gu, Charles G. Mullighan, Corbin D. Jones, Thomas B. Alexander
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Diagnostics
      Citation: JCO Precision Oncology
      PubDate: |2022-04-20T07:00:00
      DOI: 10.1200/PO.21.00326
       
  • Larotrectinib Before Initial Radioactive Iodine Therapy in Pediatric TRK
           Fusion–Positive Papillary Thyroid Carcinoma: Time to Reconsider the
           Treatment Paradigm for Distantly Metastatic Disease'

         This is an Open Access Article Open Access Article

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      Authors: Steven G. Waguespack, Sanjit O. Tewari, Naifa L. Busaidy, Mark E. Zafereo
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-04-14T07:00:00
      DOI: 10.1200/PO.21.00467
       
  • Circulating Tumor-Macrophage Fusion Cells and Circulating Tumor Cells
           Complement Non–Small-Cell Lung Cancer Screening in Patients With
           Suspicious Lung-RADS 4 Nodules

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      Authors: Yariswamy Manjunath, Kanve Nagaraj Suvilesh, Jonathan B. Mitchem, Diego M. Avella Patino, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Klaus Pantel, Huang Yi, Guangfu Li, Peter K. Harris, Aadel A. Chaudhuri, Jussuf T. Kaifi
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-04-13T07:00:00
      DOI: 10.1200/PO.21.00378
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-04-13T07:00:00
      DOI: 10.1200/PO.22.00175
       
  • Optimal Sequential Predictive Probability Designs for Early-Phase Oncology
           Expansion Cohorts

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      Authors: Emily C. Zabor, Alexander M. Kaizer, Elizabeth Garrett-Mayer, Brian P. Hobbs
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Statistical Analysis
      Citation: JCO Precision Oncology
      PubDate: |2022-04-06T07:00:00
      DOI: 10.1200/PO.21.00390
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-04-06T07:00:00
      DOI: 10.1200/PO.22.00162
       
  • Diagnostic and Prognostic Implications of GNAS Inactivation in Sonic
           Hedgehog–Activated Medulloblastoma: Case Report with Comprehensive
           Molecular Profiling and Review of Literature

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      Authors: Erin Goode, Liliana Montoya, Eric Graham, Brianna Pruniski, Curtis Simmons, Alexander Ngwube, Lindsey M. Hoffman, Nishant Tiwari, Kenneth Aldape, Harper N. Price, Vera Paulson, Ross Mangum
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-31T07:00:00
      DOI: 10.1200/PO.21.00403
       
  • Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in
           Humans Validate Preclinical Data in Ovarian Cancer

         This is an Open Access Article Open Access Article

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      Authors: Thanh H. Dellinger, Ernest S. Han, Mustafa Raoof, Byrne Lee, Xiwei Wu, Hyejin Cho, Ting-Fang He, Peter Lee, Marianne Razavi, Winnie S. Liang, Daniel Schmolze, Saul J. Priceman, Stephen Lee, Wei-Chien Lin, Jeff F. Lin, Mehdi Kebria, Amy Hakim, Nora Ruel, Daphne B. Stewart, Edward W. Wang, Benjamin I. Paz, Mark T. Wakabayashi, Mihaela C. Cristea, Lorna Rodriguez-Rodriguez
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-03-31T07:00:00
      DOI: 10.1200/PO.21.00239
       
  • Perspectives and Experiences of Parents and Adolescents Who Participate in
           a Pediatric Precision Oncology Program: "When You Feel Helpless, This Kind
           of Thing Is Very Helpful"

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      Authors: Larissa Waldman, Kelly Hancock, Bailey Gallinger, Brittney Johnstone, Ledia Brunga, David Malkin, Maru Barrera, Anita Villani
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-03-31T07:00:00
      DOI: 10.1200/PO.21.00444
       
  • PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth
           Factor Receptor 2–Positive Breast Cancer

         This is an Open Access Article Open Access Article

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      Authors: Aryana R. Rasti, Amy Guimaraes-Young, Farrah Datko, Virginia F. Borges, Dara L. Aisner, Elena Shagisultanova
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-03-31T07:00:00
      DOI: 10.1200/PO.21.00370
       
  • Exploring Survival Outcomes in Metastatic Colorectal Cancer Harboring KRAS
           A146 Mutations: Important Distinction or Simple Distraction'

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      Authors: Richard Pham, Azim Jalali, Chia Chong, Vanessa Wong, Kate Dunn, Peter Gibbs
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-28T07:00:00
      DOI: 10.1200/PO.21.00564
       
  • Reply to R. Pham et al

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      Authors: Iris van 't Erve, Cornelis J.A. Punt, Gerrit A. Meijer, Remond J.A. Fijneman
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-28T07:00:00
      DOI: 10.1200/PO.22.00053
       
  • Response to BRAF and MEK Inhibitors in BRAF Thr599dup–Mutated
           Melanoma

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      Authors: Marion Oberlé, Philippe Jamme, Sandrine Mansard, Laurent Machet, Alice Hervieu, Nora Kramkimel, Anna Greliak, Anne Sophie Jarrousse, Valentin Derangère, David Dudoignon, Clotilde Descarpentries, Laurent Mortier
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-23T07:00:00
      DOI: 10.1200/PO.21.00417
       
  • Acquired Resistance Mechanisms to PD-L1 Blockade in a Patient With
           Microsatellite Instability-High Extrahepatic Cholangiocarcinoma

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      Authors: Monica Niger, Federico Nichetti, Francesca Dell'Angelo, Vera Cappelletti, Chiara Pircher, Marta Vismara, Christian Cotsoglou, Sherrie Bhoori, Andrea Vingiani, Maria Di Bartolomeo, Filippo Pietrantonio, Filippo de Braud, Giancarlo Pruneri, Maria Grazia Daidone, Vincenzo Mazzaferro
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-23T07:00:00
      DOI: 10.1200/PO.21.00472
       
  • Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation
           With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers

         This is an Open Access Article Open Access Article

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      Authors: Mohamed E. Salem, Sherif M. El-Refai, Wei Sha, Alberto Puccini, Axel Grothey, Thomas J. George, Jimmy J. Hwang, Bert O'Neil, Alexander S. Barrett, Kunal C. Kadakia, Laura W. Musselwhite, Derek Raghavan, Eric Van Cutsem, Josep Tabernero, Jeanne Tie
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-03-23T07:00:00
      DOI: 10.1200/PO.21.00245
       
  • Identifying Outcomes of Patients With Advanced Pancreatic Adenocarcinoma
           and RECIST Stable Disease Using Radiomics Analysis

         This is an Open Access Article Open Access Article

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      Authors: Qiuxia Yang, Yize Mao, Hui Xie, Tao Qin, Zhijun Mai, Qian Cai, Hailin Wen, Yong Li, Rong Zhang, Lizhi Liu
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-03-23T07:00:00
      DOI: 10.1200/PO.21.00362
       
  • Changes in Triple-Negative Breast Cancer Molecular Subtypes in Patients
           Without Pathologic Complete Response After Neoadjuvant Systemic
           Chemotherapy

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      Authors: Hiroko Masuda, Kenichi Harano, Sakiko Miura, Ying Wang, Yuko Hirota, Oi Harada, Mohit Kumar Jolly, Yuki Matsunaga, Bora Lim, Anita L. Wood, Napa Parinyanitikul, Hee Jin Lee, Gyungyub Gong, Jason T. George, Herbert Levine, Jangsoon Lee, Xiaoping Wang, Anthony Lucci, Arvind Rao, Brock L. Schweitzer, O. Rayne Lawrence, Robert S. Seitz, Stephan W. Morris, David R. Hout, Seigo Nakamura, Savitri Krishnamurthy, Naoto T. Ueno
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-03-16T07:00:00
      DOI: 10.1200/PO.20.00368
       
  • Safety, Feasibility, and Merits of Longitudinal Molecular Testing of
           Multiple Metastatic Sites to Inform mTNBC Patient Treatment in the
           Intensive Trial of Omics in Cancer

         This is an Open Access Article Open Access Article

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      Authors: Kimberly A. Burton, Elisabeth Mahen, Eric Quentin Konnick, Sibel Blau, Michael O. Dorschner, Arturo B. Ramirez, Stephen C. Schmechel, Chaozhong Song, Rahul Parulkar, Stephanie Parker, Francis Mark Senecal, Colin C. Pritchard, Brigham H. Mecham, Christopher Szeto, Patricia Spilman, Jingchun Zhu, Vijayakrishna K. Gadi, Roy Ronen, Jackie Stilwell, Eric Kaldjian, Janusz Dutkowski, Stephen Charles Benz, Shahrooz Rabizadeh, Patrick Soon-Shiong, C. Anthony Blau
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-03-16T07:00:00
      DOI: 10.1200/PO.21.00280
       
  • FGFR Inhibitors in Cholangiocarcinoma: A Real-World Experience at a
           Tertiary Center

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      Authors: Alessandro Rizzo, Giovanni Brandi
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-16T07:00:00
      DOI: 10.1200/PO.21.00511
       
  • Reply to A. Rizzo et al

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      Authors: Jennifer Gile, Amina Jatoi, Wen Wee Ma, Mitesh Borad, Nguyen H. Tran
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-16T07:00:00
      DOI: 10.1200/PO.22.00061
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-16T07:00:00
      DOI: 10.1200/PO.22.00116
       
  • Circulating Cell-Free DNA Captures the Intratumor Heterogeneity in
           Multinodular Hepatocellular Carcinoma

         This is an Open Access Article Open Access Article

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      Authors: Mairene Coto-Llerena, Andrej Benjak, John Gallon, Marie-Anne Meier, Tuyana Boldanova, Luigi M. Terracciano, Charlotte K.Y. Ng, Salvatore Piscuoglio
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-03-09T08:00:00
      DOI: 10.1200/PO.21.00335
       
  • Comparative Study of Bayesian Information Borrowing Methods in Oncology
           Clinical Trials

         This is an Open Access Article Open Access Article

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      Authors: Liwen Su, Xin Chen, Jingyi Zhang, Fangrong Yan
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Statistical Analysis
      Citation: JCO Precision Oncology
      PubDate: |2022-03-09T08:00:00
      DOI: 10.1200/PO.21.00394
       
  • Impact of Circulating Tumor DNA–Based Detection of Molecular Residual
           Disease on the Conduct and Design of Clinical Trials for Solid Tumors

         This is an Open Access Article Open Access Article

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      Authors: Pashtoon M. Kasi, Gordon Fehringer, Hiroya Taniguchi, Naureen Starling, Yoshiaki Nakamura, Daisuke Kotani, Thomas Powles, Bob T. Li, Lajos Pusztai, Vasily N. Aushev, Ekaterina Kalashnikova, Shruti Sharma, Meenakshi Malhotra, Zachary P. Demko, Alexey Aleshin, Angel Rodriguez, Paul R. Billings, Axel Grothey, Julien Taieb, David Cunningham, Takayuki Yoshino, Scott Kopetz
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-03-09T08:00:00
      DOI: 10.1200/PO.21.00181
       
  • Immune Checkpoint Inhibition as Single Therapy for Synchronous Cancers
           Exhibiting Hypermutation: An IRRDC Study

         This is an Open Access Article Open Access Article

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      Authors: Jacob J. Henderson, Anirban Das, Daniel A. Morgenstern, Sumedha Sudhaman, Vanessa Bianchi, Jill Chung, Logine Negm, Melissa Edwards, David E. Kram, Michael Osborn, Cynthia Hawkins, Eric Bouffet, Yoon-Jae Cho, Uri Tabori
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-03-02T08:00:00
      DOI: 10.1200/PO.21.00286
       
  • Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in
           Treatment-Naive Colorectal Cancer

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      Authors: Rodrigo Gularte-Mérida, Shaleigh Smith, Anita S. Bowman, Arnaud da Cruz Paula, Walid Chatila, Craig M. Bielski, Monika Vyas, Laetitia Borsu, Ahmet Zehir, Luciano G. Martelotto, Jinru Shia, Rona Yaeger, Fang Fang, Rui Gardner, Ruibang Luo, Michael C. Schatz, Ronglai Shen, Britta Weigelt, Francisco Sánchez-Vega, Jorge S. Reis-Filho, Jaclyn F. Hechtman
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-03-02T08:00:00
      DOI: 10.1200/PO.21.00365
       
  • Cyclin-Dependent Kinase 4/6 Inhibitor Outcomes in Patients With Advanced
           Breast Cancer Carrying Germline Pathogenic Variants in DNA
           Repair–Related Genes

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      Authors: Luisina Bruno, Alexis Ostinelli, Federico Waisberg, Diego Enrico, Carolina Ponce, Sergio Rivero, Albano Blanco, Martín Zarba, Martín Loza, Verónica Fabiano, Mora Amat, María Teresa Pombo, Laura Noro, Matías Chacón, Federico Coló, Reinaldo Chacón, Jorge Nadal, Adrián Nervo, Victoria Costanzo
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-03-02T08:00:00
      DOI: 10.1200/PO.21.00140
       
  • A Case of Prostate Cancer Harboring Androgen Receptor T878A
           Progesterone-Responsive Mutant Emerging After Abiraterone Acetate
           Treatment Responding to Darolutamide

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      Authors: Andreas Varkaris, Julia Stevens, Yuho Ono, Steven P. Balk, Joaquim Bellmunt
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-02-24T08:00:00
      DOI: 10.1200/PO.21.00091
       
  • Validity of 1% Hormonal Receptor Positivity Cutoff by the ASCO/College of
           American Pathologists Guidelines at the Georgia Cancer Center

         This is an Open Access Article Open Access Article

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      Authors: Firas Kreidieh, Ramses F. Sadek, Li Fang Zhang, Aaron Gopal, Jean-Pierre Blaize, David Yashar, Reena Patel, Hiral S. Patel, Shou-Ching Tang, Houssein Abdul Sater
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-02-24T08:00:00
      DOI: 10.1200/PO.21.00201
       
  • PTEN Loss and BRCA1 Promoter Hypermethylation Negatively Predict for
           Immunogenicity in BRCA-Deficient Ovarian Cancer

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      Authors: Adam A. Kraya, Kara N. Maxwell, Monika A. Eiva, Bradley Wubbenhorst, John Pluta, Michael Feldman, Anupma Nayak, Daniel J. Powell, Susan M. Domchek, Robert H. Vonderheide, Katherine L. Nathanson
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-02-24T08:00:00
      DOI: 10.1200/PO.21.00159
       
  • Clinical Opportunities for Germline Pharmacogenetics and Management of
           Drug-Drug Interactions in Patients With Advanced Solid Cancers

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      Authors: Tyler Shugg, Reynold C. Ly, Elizabeth J. Rowe, Santosh Philips, Mustafa A. Hyder, Milan Radovich, Marc B. Rosenman, Victoria M. Pratt, John T. Callaghan, Zeruesenay Desta, Bryan P. Schneider, Todd C. Skaar
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-02-24T08:00:00
      DOI: 10.1200/PO.21.00312
       
  • Plasma Cell-Free DNA Integrity Assessed by Automated Electrophoresis
           Predicts the Achievement of Pathologic Complete Response to Neoadjuvant
           Chemotherapy in Patients With Breast Cancer

         This is an Open Access Article Open Access Article

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      Authors: Gabriella Cirmena, Lorenzo Ferrando, Francesco Ravera, Anna Garuti, Martina Dameri, Maurizio Gallo, Valentina Barbero, Fabio Ferrando, Lucia Del Mastro, Alessandro Garlaschi, Daniele Friedman, Piero Fregatti, Alberto Ballestrero, Gabriele Zoppoli
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-02-24T08:00:00
      DOI: 10.1200/PO.21.00198
       
  • Clinical Validity of Plasma-Based Genotyping for Microsatellite
           Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy
           

         This is an Open Access Article Open Access Article

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      Authors: Yoshiaki Nakamura, Wataru Okamoto, Tadamichi Denda, Tomohiro Nishina, Yoshito Komatsu, Satoshi Yuki, Hisateru Yasui, Taito Esaki, Yu Sunakawa, Makoto Ueno, Eiji Shinozaki, Nobuhisa Matsuhashi, Takashi Ohta, Ken Kato, Koushiro Ohtsubo, Hideaki Bando, Hiroki Hara, Taroh Satoh, Kentaro Yamazaki, Yoshiyuki Yamamoto, Naohiro Okano, Tetsuji Terazawa, Takeshi Kato, Eiji Oki, Akihito Tsuji, Yosuke Horita, Yasuo Hamamoto, Akihito Kawazoe, Hiromichi Nakajima, Shogo Nomura, Ryuta Mitani, Mihoko Yuasa, Kiwamu Akagi, Takayuki Yoshino
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-02-21T08:00:00
      DOI: 10.1200/PO.21.00383
       
  • Utility of Perioperative Measurement of Cell-Free DNA and Circulating
           Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review

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      Authors: Phillip J. Hsu, Khushboo Singh, Ankit Dhiman, Hunter D. D. Witmer, Chuan He, Oliver S. Eng, Daniel V. T. Catenacci, Mitchell C. Posner, Kiran K. Turaga
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-02-21T08:00:00
      DOI: 10.1200/PO.21.00337
       
  • Real-World Experience of NTRK Fusion–Positive Thyroid Cancer
         This is an Open Access Article Open Access Article

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      Authors: Jong Chul Park, Arya Ashok, Chienying Liu, Hyunseok Kang
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-02-16T08:00:00
      DOI: 10.1200/PO.21.00442
       
  • Biomarker-Based Phase II Study of Sapanisertib (TAK-228): An mTORC1/2
           Inhibitor in Patients With Refractory Metastatic Renal Cell Carcinoma

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      Authors: Bradley A. McGregor, Wanling Xie, Elio Adib, Walter M. Stadler, Yousef Zakharia, Aijai Alva, M. Dror Michaelson, Shilpa Gupta, Elaine T. Lam, Subrina Farah, Amin H. Nassar, Xiao X. Wei, Kerry L. Kilbridge, Lauren Harshman, Sabina Signoretti, Lynette Sholl, David J. Kwiatkowski, Rana R. McKay, Toni K. Choueiri
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-02-16T08:00:00
      DOI: 10.1200/PO.21.00448
       
  • Monitoring of Dynamic Changes and Clonal Evolution in Circulating Tumor
           DNA From Patients With IDH-Mutated Cholangiocarcinoma Treated With
           Isocitrate Dehydrogenase Inhibitors

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      Authors: Morten Lapin, Helen J. Huang, Sharmeen Chagani, Milind Javle, Rachna T. Shroff, Shubham Pant, Mohamed A. Gouda, Anjali Raina, Kiran Madwani, Veronica R. Holley, S. Greg Call, Derek J. Dustin, Richard B. Lanman, Funda Meric-Bernstam, Victoria M. Raymond, Lawrence N. Kwong, Filip Janku
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-02-16T08:00:00
      DOI: 10.1200/PO.21.00197
       
  • Identification of Recurrent Insertions and Deletions in Exon 18 and 19 of
           Human Epidermal Growth Factor Receptor 2 as Potential Drivers in
           Non–Small-Cell Lung Cancer and Other Cancer Types

         This is an Open Access Article Open Access Article

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      Authors: Yan Yin, Lijie Song, Dongsheng Shi, Bin Liu, Xiangke Li, Minjie Yang, Bihao Liu, Dejuan Wang, Jianwen Qin
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-02-16T08:00:00
      DOI: 10.1200/PO.21.00325
       
  • Lymphomatous Meningitis From Anaplastic Lymphoma Kinase+ Anaplastic Large
           T-Cell Lymphoma Treated With Lorlatinib: A Case Report

         This is an Open Access Article Open Access Article

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      Authors: Smitha Mellacheruvu, Mark N. Sayegh, R. Alejandro Sica, Haiying Cheng, Maria Laureana Santos-Zabala, Jacob H. Gebrael, Ulrich Hermanto, Norman L. Rosen
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-02-09T08:00:00
      DOI: 10.1200/PO.21.00250
       
  • Phase Ib SEASTAR Study: Combining Rucaparib and Sacituzumab Govitecan in
           Patients With Cancer With or Without Mutations in Homologous Recombination
           Repair Genes

         This is an Open Access Article Open Access Article

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      Authors: Timothy A. Yap, Erika Hamilton, Todd Bauer, Ecaterina E. Dumbrava, Rinath Jeselsohn, Aaron Enke, Sabrina Hurley, Kevin K. Lin, Jenn Habeck, Heidi Giordano, Geoffrey I. Shapiro
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-02-09T08:00:00
      DOI: 10.1200/PO.21.00456
       
  • Phase II Study of Taselisib in PIK3CA-Mutated Solid Tumors Other Than
           Breast and Squamous Lung Cancer: Results From the NCI-MATCH ECOG-ACRIN
           Trial (EAY131) Subprotocol I

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      Authors: Ian E. Krop, Opeyemi A. Jegede, Juneko E. Grilley-Olson, Josh D. Lauring, Edith P. Mitchell, James A. Zwiebel, Robert J. Gray, Victoria Wang, Lisa M. McShane, Larry V. Rubinstein, David Patton, P. Mickey Williams, Stanley R. Hamilton, Scott A. Kono, James M. Ford, Agustin A. Garcia, Xingwei D. Sui, Robert D. Siegel, Brian M. Slomovitz, Barbara A. Conley, Carlos L. Arteaga, Lyndsay N. Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-02-09T08:00:00
      DOI: 10.1200/PO.21.00424
       
  • Defining and Targeting Esophagogastric Cancer Genomic Subsets With
           Patient-Derived Xenografts

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      Authors: Ryan H. Moy, Henry S. Walch, Marissa Mattar, Walid K. Chatila, Daniela Molena, Vivian E. Strong, Laura H. Tang, Steven B. Maron, Daniel G. Coit, David R. Jones, Jaclyn F. Hechtman, David B. Solit, Nikolaus Schultz, Elisa de Stanchina, Yelena Y. Janjigian
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-02-09T08:00:00
      DOI: 10.1200/PO.21.00242
       
  • Treatment of Disseminated Intravenous Leiomyomatosis With ALK Targeting
           Crizotinib: A Successful Case Report

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      Authors: Priscila Barreto-Coelho, Andrew Rosenberg, Ty Subhawong, Philippos Costa, Andrea P. Espejo-Freire, Steven Bialick, Emily Jonczak, Jonathan C. Trent, Gina Z. D'Amato
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-02-02T08:00:00
      DOI: 10.1200/PO.21.00336
       
  • Clinical and Molecular Characterization of POLE Mutations as Predictive
           Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers
           

         This is an Open Access Article Open Access Article

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      Authors: Benjamin Garmezy, Jinesh Gheeya, Heather Y. Lin, Yuefan Huang, Taebeom Kim, Xianli Jiang, Kyaw Z. Thein, Patrick G. Pilié, Fadl Zeineddine, Wanlin Wang, Kenna R. Shaw, Jordi Rodon, John Paul Shen, Ying Yuan, Funda Meric-Bernstam, Ken Chen, Timothy A. Yap
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-02-02T08:00:00
      DOI: 10.1200/PO.21.00267
       
  • Distinct Genomic Landscapes in Early-Onset and Late-Onset Endometrial
           Cancer

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      Authors: Jungyoon Choi, Andreana N. Holowatyj, Mengmeng Du, Zhishan Chen, Wanqing Wen, Nikolaus Schultz, Loren Lipworth, Xingyi Guo
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genetics
      Citation: JCO Precision Oncology
      PubDate: |2022-02-02T08:00:00
      DOI: 10.1200/PO.21.00401
       
  • Clinical Utility of CDK4/6 Inhibitors in Sarcoma: Successes and Future
           Challenges

         This is an Open Access Article Open Access Article

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      Authors: Jocelyn Y. Hsu, Nathan D. Seligson, John L. Hays, Wayne O. Miles, James L. Chen
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-02-02T08:00:00
      DOI: 10.1200/PO.21.00211
       
  • Clinical Utility of Genomic Testing in Cancer Care
         This is an Open Access Article Open Access Article

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      Authors: Daryl Pritchard, Clifford Goodman, Lincoln D. Nadauld
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-27T08:00:00
      DOI: 10.1200/PO.21.00349
       
  • Sustained Response to Entrectinib in an Infant With a Germline ALKAL2
           Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain
           

         This is an Open Access Article Open Access Article

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      Authors: Diana Treis, Ganesh Umapathy, Susanne Fransson, Jikui Guan, Patricia Mendoza-García, Joachim T. Siaw, Sandra Wessman, Lena Gordon Murkes, Jakob J. E. Stenman, Anna Djos, Lotta H. M. Elfman, John Inge Johnsen, Bengt Hallberg, Ruth H. Palmer, Tommy Martinsson, Per Kogner
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-27T08:00:00
      DOI: 10.1200/PO.21.00271
       
  • Exceptional Response to Olaparib and Pembrolizumab for Pancreatic
           Adenocarcinoma With Germline BRCA1 Mutation and High Tumor Mutation
           Burden: Case Report and Literature Review

         This is an Open Access Article Open Access Article

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      Authors: Joanne Lundy, Owen McKay, Daniel Croagh, Vinod Ganju
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-27T08:00:00
      DOI: 10.1200/PO.21.00437
       
  • Urinary 3-Methoxytyramine Is a Biomarker for MYC Activity in Patients With
           Neuroblastoma

         This is an Open Access Article Open Access Article

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      Authors: Iedan R. N. Verly, Yvette A. H. Matser, René Leen, Rutger Meinsma, Marta Fiocco, Jan Koster, Richard Volckmann, Dilara Savci-Heijink, Giuliana Cangemi, Sebastiano Barco, Linda J. Valentijn, Godelieve A. M. Tytgat, André B. P. van Kuilenburg
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-01-27T08:00:00
      DOI: 10.1200/PO.20.00447
       
  • Improved Gene Fusion Detection in Childhood Cancer Diagnostics Using RNA
           Sequencing

         This is an Open Access Article Open Access Article

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      Authors: Jayne Y. Hehir-Kwa, Marco J. Koudijs, Eugene T. P. Verwiel, Lennart A. Kester, Marc van Tuil, Eric Strengman, Arjan Buijs, Mariëtte E. G. Kranendonk, Laura S. Hiemcke-Jiwa, Valerie de Haas, Ellen van de Geer, Wendy de Leng, Jasper van der Lugt, Philip Lijnzaad, Frank C. P. Holstege, Patrick Kemmeren, Bastiaan B. J. Tops
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Diagnostics
      Citation: JCO Precision Oncology
      PubDate: |2022-01-27T08:00:00
      DOI: 10.1200/PO.20.00504
       
  • Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor
           Kinase Fusion–Positive Lung Cancers

         This is an Open Access Article Open Access Article

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      Authors: Alexander Drilon, Daniel S. W. Tan, Ulrik N. Lassen, Serge Leyvraz, Yongmei Liu, Jyoti D. Patel, Lee Rosen, Benjamin Solomon, Ricarda Norenberg, Laura Dima, Nicoletta Brega, Lin Shen, Victor Moreno, Shivaani Kummar, Jessica J. Lin
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-01-27T08:00:00
      DOI: 10.1200/PO.21.00418
       
  • Sustained Response to the Mitogen-Activated Extracellular Kinase Inhibitor
           Trametinib in a Spindle Cell Sarcoma Harboring a QKI-RAF1 Gene Fusion

         This is an Open Access Article Open Access Article

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      Authors: François Panet, Sungmi Jung, Thierry Alcindor
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-20T08:00:00
      DOI: 10.1200/PO.21.00303
       
  • Apolipoprotein B mRNA-Editing Catalytic Polypeptide-Like–Induced Protein
           Changes in Estrogen Receptor–Positive, Human Epidermal Growth Factor
           Receptor 2–Negative Breast Cancer Throughout Disease Progression

         This is an Open Access Article Open Access Article

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      Authors: Manouk K. Bos, Marcel Smid, Stefan Sleijfer, John W. M. Martens
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genomics
      Citation: JCO Precision Oncology
      PubDate: |2022-01-20T08:00:00
      DOI: 10.1200/PO.21.00190
       
  • ERBB2 Copy Number as a Quantitative Biomarker for Real-World Outcomes to
           Anti–Human Epidermal Growth Factor Receptor 2 Therapy in Advanced
           Gastroesophageal Adenocarcinoma

         This is an Open Access Article Open Access Article

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      Authors: Liangliang Zhang, Omar Hamdani, Ole Gjoerup, Cheryl Cho-Phan, Jeremy Snider, Emily Castellanos, Halla Nimeiri, Garrett Frampton, Jeffrey M. Venstrom, Geoffrey Oxnard, Samuel J. Klempner, Alexa B. Schrock
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-01-20T08:00:00
      DOI: 10.1200/PO.21.00330
       
  • Real-World Analysis of Off-Label Use of Molecularly Targeted Therapy in a
           Large Academic Medical Center Cohort

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      Authors: Vivek A. Upadhyay, Bruce E. Johnson, Adam B. Landman, Michael J. Hassett
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Targeted Drug Therapy
      Citation: JCO Precision Oncology
      PubDate: |2022-01-20T08:00:00
      DOI: 10.1200/PO.21.00232
       
  • Tumor-Informed Versus Plasma-Only Liquid Biopsy Assay in a Patient With
           Multiple Primary Malignancies

         This is an Open Access Article Open Access Article

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      Authors: Pashtoon Murtaza Kasi
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-18T08:00:00
      DOI: 10.1200/PO.21.00298
       
  • Case of Metastatic Pheochromocytoma and Meningiomas in a Patient With
           Lynch Syndrome

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      Authors: Meryl D. Colton, Kenneth Tompkins, Emily O'Donnell, Dara Aisner, Christopher H. Lieu, Eric Q. Konnick, Lauren Fishbein
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-13T08:00:00
      DOI: 10.1200/PO.21.00251
       
  • Circulating T-Cell Repertoires Correlate With the Tumor Response in
           Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy

         This is an Open Access Article Open Access Article

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      Authors: Gengxi Cai, Zhanwen Guan, Yabin Jin, Zuhui Su, Xiangping Chen, Qing Liu, Chunlin Wang, Xiaoxia Yin, Lifang Zhang, Guolin Ye, Wei Luo
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-01-13T08:00:00
      DOI: 10.1200/PO.21.00120
       
  • Mainstreaming Genetic Testing for Epithelial Ovarian Cancer by Oncology
           Providers: A Survey of Current Practice

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      Authors: Megan A. Czekalski, Rachelle C. Huziak, Andrea L. Durst, Sarah Taylor, Phuong L. Mai
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Cancer Genetics
      Citation: JCO Precision Oncology
      PubDate: |2022-01-13T08:00:00
      DOI: 10.1200/PO.21.00409
       
  • Mutant PPM1D- and TP53-Driven Hematopoiesis Populates the Hematopoietic
           Compartment in Response to Peptide Receptor Radionuclide Therapy

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      Authors: Abhay Singh, Nuria Mencia-Trinchant, Elizabeth A. Griffiths, Alaa Altahan, Mahesh Swaminathan, Medhavi Gupta, Matthew Gravina, Rutaba Tajammal, Mark G. Faber, LunBiao Yan, Eti Sinha, Duane C. Hassane, David Neil Hayes, Monica L. Guzman, Renuka Iyer, Eunice S. Wang, Swapna Thota
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-01-13T08:00:00
      DOI: 10.1200/PO.21.00309
       
  • Erratum

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      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-13T08:00:00
      DOI: 10.1200/PO.21.00566
       
  • Real-World Data From a Molecular Tumor Board: Improved Outcomes in Breast
           and Gynecologic Cancers Patients With Precision Medicine

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      Authors: Lindsey M. Charo, Ramez N. Eskander, Jason Sicklick, Ki Hwan Kim, Hyo Jeong Lim, Ryosuke Okamura, Suzanna Lee, Rupa Subramanian, Richard Schwab, Rebecca Shatsky, Steven Plaxe, Shumei Kato, Razelle Kurzrock
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-01-06T08:00:00
      DOI: 10.1200/PO.20.00508
       
  • Systematic Review of Molecular Biomarkers Predictive of Resistance to
           CDK4/6 Inhibition in Metastatic Breast Cancer

         This is an Open Access Article Open Access Article

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      Authors: Uzma S. Asghar, Ruhi Kanani, Rebecca Roylance, Sibylle Mittnacht
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Biomarkers
      Citation: JCO Precision Oncology
      PubDate: |2022-01-06T08:00:00
      DOI: 10.1200/PO.21.00002
       
  • Lasting Complete Clinical Response of a Recurring Cutaneous Squamous Cell
           Carcinoma With MEK Mutation and PIK3CA Amplification Achieved by Dual
           Trametinib and Metformin Therapy

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      Authors: Éva Remenár, Róbert Dóczi, Anna Dirner, Anna Sipos, Anita Perjési, Dóra Tihanyi, Barbara Vodicska, Dóra Lakatos, Katalin Horváth, Kornélia Kajáry, Richárd Schwáb, Júlia Déri, Csongor György Lengyel, Edit Várkondi, István Vályi-Nagy, István Peták
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-06T08:00:00
      DOI: 10.1200/PO.21.00344
       
  • Exceptional Clinical Response to Alectinib in Pancreatic Acinar Cell
           Carcinoma With a Novel ALK-KANK4 Gene Fusion

         This is an Open Access Article Open Access Article

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      Authors: Marina Gaule, Camilla Pesoni, Alberto Quinzii, Camilla Zecchetto, Simona Casalino, Valeria Merz, Serena Contarelli, Silvia Pietrobono, Elena Vissio, Luca Molinaro, Enrica Manzin, Roberta Volpatto, Giorgio Vellani, Davide Melisi
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Citation: JCO Precision Oncology
      PubDate: |2022-01-05T08:00:00
      DOI: 10.1200/PO.21.00400
       
  • Isocitrate Dehydrogenase–Mutated Cholangiocarcinoma: Natural History
           and Clinical Outcomes

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      Authors: Grant Wintheiser, Tyler Zemla, Qian Shi, Nguyen Tran, Kritika Prasai, Sri Harsha Tella, Kabir Mody, Daniel Ahn, Mitesh Borad, Tanios Bekaii-Saab, Amit Mahipal
      Abstract: JCO Precision Oncology, Volume , Issue 6, April 2022.

      Keywords: Precision Medicine
      Citation: JCO Precision Oncology
      PubDate: |2022-01-05T08:00:00
      DOI: 10.1200/PO.21.00156
       
 
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