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Indonesian Journal of Pharmaceutical Education
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2775-3670
Published by Universitas Negeri Gorontalo Homepage  [3 journals]
  • EFFECT OF VARIATION OF LUBRICANT CONCENTRATION (MAGNESIUM STEARATE) ON THE
           

    • Authors: Valiandri Puspadina, Deny Budi Legowo, Erna Fitriany, Andri Priyoherianto, Winda Damayanti
      Pages: 67 - 75
      Abstract: Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain a better physical quality test including organoleptics, weight uniformity, uniformity of size, tablet hardness, tablet brittleness, tablet crush time, uniformity of content. The results of the physical quality test were statistically analyzed using one way ANOVA to determine the effect of variations in the concentration of lubricants on the characteristics of chewable tablets. The results showed that variations in the concentration of magnesium stearate lubricant in the manufacture of metoclopramide HCl chewable tablets had an effect on the physical quality of metoclopramide HCl chewable tablets. The concentration of magnesium stearate which produces metoclopramide HCl chewable tablets with good physical properties is 2%.
      PubDate: 2021-05-27
      Issue No: Vol. 1, No. 2 (2021)
       
  • Uji Mutu Fisik Metoklopramid HCl Tablet Chewable dengan Variasi Jenis
           Pengisi sebagai Diluent menggunakan Metode Granulasi Basah

    • Authors: Umi Latifiana, Deny Budi Legowo, erna fitriany, Andri Priyoherianto, Muhammad Novianto Ainul Huri
      Pages: 76 - 85
      Abstract: Metoclopramide HCl are used to reduce vomiting and nausea. The availability on the market in the form of tablet, syrup and injection. Patient tend to prefer take drugs by oral use because it was easier. Chewable tablet is the new product as the alternative ways to treatment children and adult patient who had difficulity problem of swallowing drugs. Objectives: This research aims to formulate the chewable metoclopramide HCl tablets using diluent variations to get a better physical quality test. Chewable tablets of metoclopramide HCl are made using diluent variations, they are mannitol, sucrose, lactose. Formula I mannitol, formula II sucrose, and formula III lactose. Chewable tablet preparations are made by the wet granulation method. Data collection was performed on physical characteristics including organoleptic, weight uniformity, uniformity of size, tablet hardness, tablet fragility, disintegration time, metoclopramide HCl levels. Physical quality test results were statistically analyzed to determine the effect of variations in the diluent on the characteristics of chewable tablets. The results of this research have an influence on the physical quality and uniformity of contents of various types of diluent variations between each formulation. In this research, fillers have an important role in the preparation of chewable metoclopramide tablets to determine the physical quality of the tablets and the uniformity of their contents. The variation of diluent that gives better results is mannitol. This is because formulas that use mannitol have uniformity in content that meets the requirements, faster disintegration time, and physical quality of tablets that still meet the requirements, when compared to the first and second formulations. The variation of diluent that gives better results is mannitol.
      PubDate: 2021-06-02
      Issue No: Vol. 1, No. 2 (2021)
       
  • Hubungan Antara Kepatuhan Minum Obat (MMAS-8) Dan Kualitas Hidup
           (WHOQOL-BREF) Penderita Tuberkulosis Di Puskesmas Di Kota Bandung

    • Authors: Dizky Ramadani Putri Papeo, Maria Immaculata, Iis Rukmawati
      Pages: 86 - 97
      Abstract: Backgroumd: Tuberculosis (TB) is an infectious disease which is until now has not been able to be threated, i.e., because of patient non-adherence in taking anti-tuberculosis drug (ATD) Objective: The objective of this research is  to study the relationship between patients adherence in taking ATD determined by MMAS-8 questionnaire with QoL of patient determined by WHOQOL questionnaire. Method: Tuberculosis patients who undergo treatment for at least 4 weeks are the subjects in this study. This study was conducted by a cross-sectional method using the MMAS-8 and WHOQOL-BREF questionnaire of tuberculosis patients at Ibrahim Adjiand Gumuruh primary health care during March - August 2018. Result: Based on MMAS-8 questionnaire filled out by 75 patients, there was 69% of high adherence, 15% moderate,  and 16% has low adherence in taking ATD. Of the 6 characteristic factors (i.e., age, sex, occupation, income, education and length of treatment), only gender (p0.01) and occupation (p0.03) factors that influence the patient adherence significantly. Based on MMAS-8 and WHOQOL-BREF questionnaire analyses, there is only psychological health aspect (domain two) that have a significant (p = 0.01) correlated with patient adherence. Conclusion: Based on the results,the psychological health of tuberculosis patients play an important role in patient adherence. 
      PubDate: 2021-07-10
      Issue No: Vol. 1, No. 2 (2021)
       
  • Uji Toksisitas Akut Ekstrak Air Dan Ekstrak Etanol Daun Kacapiring
           (Gardenia jasminoides Ellis) Terhadap Larva Artemia Salina Leach Dengan
           Metode Brine Shrimp Lethality Test (BSLT)

    • Authors: Nuralifah Nuralifah, Parawansah Parawansah, Hasniana Nur
      Pages: 98 - 106
      Abstract: A toxicity test is a test to detect the toxic effect of a substance on a biological system and to obtain typical dose-response data from the test preparation. This study aims to determine the content of secondary metabolites from the aqueous extract and ethanolic extract of gardenia leaves, characterization of gardenia leaf extract, and acute toxicity using the BSLT method against Artemia salina Leach shrimp larvae.Phytochemical screening tests were carried out by the color change method which included the alkaloid test, flavonoid test, tannin test, saponin test, and terpenoid test. Extract characterization tests include determination of water-soluble extract, determination of ethanol-soluble extract, determination of water content, and determination of ash content. Acute toxicity test using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae.The results of the phytochemical screening test for the aqueous extract of gardenia leaves showed positive results on saponins, while the phytochemical screening tests on ethanol extracts showed positive results on alkaloids, flavonoids, saponins, tannins, and terpenoids. The results of the characterization test on the aqueous extract of gardenia leaves were that the ethanol-soluble extract content was 20.19%, the water-soluble extract content was 23.17%, the water content was 99.13% and the ash content was 0.29%. Meanwhile, in the ethanolic extract of gardenia leaves, the ethanol-soluble extract content was 60.80%, the water-soluble extract content was 57.14%, the water content was 7.87% and the ash content was 3.22%. The results show that gardenia leaves are not toxic with the LC50 value of the water extract of the gardenia leaves is 1399.64 g/mL and the LC50 value of the ethanolic extract of the gardenia leaves is 1080.96 so that it can be used as traditional medicine. 
      PubDate: 2021-05-30
      Issue No: Vol. 1, No. 2 (2021)
       
 
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