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Journal of Applied Pharmaceutical Sciences and Research
Number of Followers: 7  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2581-5520
Published by MRI Publishers Pvt. Ltd. Homepage  [1 journal]
  • ROLE OF KYNURENINE PATHWAY METABOLITES IN DEPRESSION-A REVIEW

    • Authors: Priyadarshini soni; Lubhan Singh, Prabhat Singh, Sokindra Kumar
      Abstract: Today most common psychiatric problem across the world is depression and stress is main source of ailment. According to World health organization, it will be the main cause of morbidity by 2020 in the world. Depression can critically affects the quality of life  as it is characterized by many symptoms like unhappy feeling, lack of interest and pleasure, down energy, inadequacy, regret feeling, slow-down of thoughts or reduction in physical movement, speech can affects, altered appetite or sleep, sad,  and increase the risk of suicide. Human body is inadequate to produce tryptophan which is a crucial amino acid; therefore it must be required from diet. After absorption, L-tryptophan crosses the BBB (Blood brain barrier) by non-specific L-type amino acid transporter and act as precursor to various metabolic pathways in central nervous system (CNS). Kynurenine is an important pathway that is associated with tryptophan (TRP) metabolism, where it develops a lot of metabolites such as 3-hydroxykynurenine (3HK), anthranilic acid (AA), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA) and quinolinic acid (QUIN) known as kynurenines. It is already reported previously that disturbance in neuroprotective and neurotoxic metabolites leads to many psychiatric disorders. This review summarizes the role of kynurenine pathway metabolites in depression.   
      PubDate: Thu, 17 Dec 2020 00:00:00 +053
       
  • LIPOSOMAL DRUG DELIVERY SYSTEM – A REVIEW

    • Authors: Anchal Srivastava; Amresh Gupta, Arpita Singh
      Abstract: A liposome is the drug delivery system which is used for the administration of various types of drugs or active substance(1) are essential for the treatment of various types of disease. A liposome is a very effective drug delivery system to Target the active medicament to an effective part of the body without entrapping or affecting the other body part that's why it is also called the targeted drug delivery system. Liposomes are available in various sizes to the range for treatment to various types of disease as the carrier for targeted the medicament or drug to active site at a predetermined rate & time range, without affecting the other body part for the treatment of a particular disease. they are colloidal spheres of cholesterol non-poisonous surfactants, sphingolipids, glycolipids, long-chain unsaturated fats, and even layer proteins and active atoms or it is also called vesicular system. (2) this review discusses the advantages and disadvantages, various methods of preparation, evaluation, etc.
      PubDate: Thu, 17 Dec 2020 00:00:00 +053
       
  • CORONA VIRUS OUTBREAK AND IT’S IMPACT ON THE GLOBAL PHARMACEUTICAL
           INDUSTRIES

    • Authors: Vikas Sharma; Chandana Majee, Rahul Kaushik; Divya Sharma; Sunita Kumari, Rajni Sawanny, Shivali Bhardwaj, Baitullah Abdali
      Abstract: There is another general wellbeing emergencies undermining the world with the rise and spread of 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection started in bats and was transmitted to people through yet obscure go-between creatures in Wuhan, Hubei territory, China in December 2019. There are more than 48,15,484 infected cases all around the globe. This can be transmitted from one to another very quickly only by coughing or sneezing or direct contact with infected person. World Health Organization also has stated that there is no future course of this virus is available till now. As a preventive measure the complete stop on outgoings i.e. lockdown is surrendered. The lockdown all over the country or all around the globe is becoming a huge crisis for the economy and of countries the life cycle of the humans. The lockdown has affected all the businesses, works, private sectors as well as government sectors. The impact of lockdown on the pharmaceutical industries can be a great boon if its taken positively. Keywords: coronavirus, SARS-CoV 2, wuhan, transmitted, crisis, lockdown, impact.
      PubDate: Thu, 17 Dec 2020 00:00:00 +053
       
  • TOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS
           ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS

    • Authors: Aruna Pai; Jvln Seshagiri Rao, Madhu J Rajendra, Ashish S Jain
      Abstract: Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream in ultraviolet –B-induced psoriasis in rats. Materials &Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol, methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content was determined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of the optimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm with UV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined. Results and Discussion: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and  Total triterpenoid (mg ursolic acid/ g) content was found to be significant for water extract.The reducing ability of water extract was always higher than methanol extract at all the concentrations. Conclusion: We concluded that cream containing 0.1% water extract of Terminalia chebula seeds possess antioxidant activity along with potent antipsoriatic activity. Further, application of Terminalia chebula cream resulted in decrease in relative epidermal thickness of animal skin as well as other histopathological features. The present investigation aims at the development of potent phytomedicine for treatment of psoriasis from the Terminalia chebula plant.
      PubDate: Thu, 17 Dec 2020 00:00:00 +053
       
 
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