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Journal Cover
Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 960  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3162 journals]
  • Finding Genetic Regulators, Forecasting Function
    • Authors: Lara Szewczak
      First page: 247
      Abstract: The advent of whole-genome sequencing promised, among other things, that variants affecting regulatory regions of the genome could be identified to provide insight into inherited pathologies or the impact of de novo mutations. These gains are accruing but still lag expectations. While whole-genome sequences accumulate in both academic and clinical settings, one inescapable limitation is that identifying functional regulatory sequences—be they enhancers, promoters, UTRs—that control specific genes remains difficult at the level of basic research.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.043
      Issue No: Vol. 174, No. 2 (2018)
       
  • The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis
    • Authors: Yoku Hayakawa; Timothy C. Wang
      Pages: 251 - 253
      Abstract: The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.037
      Issue No: Vol. 174, No. 2 (2018)
       
  • Translating the Physical Code of Life
    • Authors: Benjamin D. Knapp; Kerwyn Casey Huang
      Pages: 253 - 255
      Abstract: The cytoplasm is a highly crowded and complex environment, and the regulation of its physical properties has only recently begun to be revealed. In this issue of Cell, Delarue et al. demonstrate that the control of ribosome concentration through mTORC1 sets limits on the diffusion of large particles and controls phase separation in eukaryotic cells.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.050
      Issue No: Vol. 174, No. 2 (2018)
       
  • An Algal Greening of Land
    • Authors: William F. Martin; John F. Allen
      Pages: 256 - 258
      Abstract: Photosynthetic eukaryotes arose ∼1.5 billion years ago by endosymbiosis with a cyanobacterium. Algae then evolved for a billion years before one lineage finally colonized land. Why the wait' The Chara braunii genome details a decisive step linking plant origins with Earth’s history.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.034
      Issue No: Vol. 174, No. 2 (2018)
       
  • Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of
           Immune Surveillance
    • Authors: Wen Zhou; Aaron T. Whiteley, Carina C. de Oliveira Mann, Benjamin R. Morehouse, Radosław P. Nowak, Eric S. Fischer, Nathanael S. Gray, John J. Mekalanos, Philip J. Kranzusch
      Pages: 300 - 311.e11
      Abstract: The structure of the human cGAS–DNA complex reveals regulatory adaptations that balance enzymatic activity with DNA-length sensitivity, and additional features important for drug design.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.026
      Issue No: Vol. 174, No. 2 (2018)
       
  • The Chara Genome: Secondary Complexity and Implications for Plant
           Terrestrialization
    • Authors: Tomoaki Nishiyama; Hidetoshi Sakayama, Jan de Vries, Henrik Buschmann, Denis Saint-Marcoux, Kristian K. Ullrich, Fabian B. Haas, Lisa Vanderstraeten, Dirk Becker, Daniel Lang, Stanislav Vosolsobě, Stephane Rombauts, Per K.I. Wilhelmsson, Philipp Janitza, Ramona Kern, Alexander Heyl, Florian Rümpler, Luz Irina A. Calderón Villalobos, John M. Clay, Roman Skokan, Atsushi Toyoda, Yutaka Suzuki, Hiroshi Kagoshima, Elio Schijlen, Navindra Tajeshwar, Bruno Catarino, Alexander J. Hetherington, Assia Saltykova, Clemence Bonnot, Holger Breuninger, Aikaterini Symeonidi, Guru V. Radhakrishnan, Filip Van Nieuwerburgh, Dieter Deforce, Caren Chang, Kenneth G. Karol, Rainer Hedrich, Peter Ulvskov, Gernot Glöckner, Charles F. Delwiche, Jan Petrášek, Yves Van de Peer, Jiri Friml, Mary Beilby, Liam Dolan, Yuji Kohara, Sumio Sugano, Asao Fujiyama, Pierre-Marc Delaux, Marcel Quint, Günter Theißen, Martin Hagemann, Jesper Harholt, Christophe Dunand, Sabine Zachgo, Jane Langdale, Florian Maumus, Dominique Van Der Straeten, Sven B. Gould, Stefan A. Rensing
      Pages: 448 - 464.e24
      Abstract: The draft genome of Chara braunii reveals many plant-like features important for colonization of land that evolved in charophytic algae and therefore prior to the earliest land plants.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.033
      Issue No: Vol. 174, No. 2 (2018)
       
  • A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced
           Brain-Cell-Type Targeting and Functionality
    • Authors: Tanya L. Daigle; Linda Madisen, Travis A. Hage, Matthew T. Valley, Ulf Knoblich, Rylan S. Larsen, Marc M. Takeno, Lawrence Huang, Hong Gu, Rachael Larsen, Maya Mills, Alice Bosma-Moody, La’ Akea Siverts, Miranda Walker, Lucas T. Graybuck, Zizhen Yao, Olivia Fong, Thuc Nghi Nguyen, Emma Garren, Garreck H. Lenz, Mariya Chavarha, Julie Pendergraft, James Harrington, Karla E. Hirokawa, Julie A. Harris, Philip R. Nicovich, Medea J. McGraw, Douglas R. Ollerenshaw, Kimberly A. Smith, Christopher A. Baker, Jonathan T. Ting, Susan M. Sunkin, Jérôme Lecoq, Michael Z. Lin, Edward S. Boyden, Gabe J. Murphy, Nuno M. da Costa, Jack Waters, Lu Li, Bosiljka Tasic, Hongkui Zeng
      Pages: 465 - 480.e22
      Abstract: An expanded toolkit of transgenic mouse lines for exploring the organization, function, and development of mammalian neural circuits.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.035
      Issue No: Vol. 174, No. 2 (2018)
       
  • A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific
           Detection of Dopamine in Flies, Fish, and Mice
    • Authors: Fangmiao Sun; Jianzhi Zeng, Miao Jing, Jingheng Zhou, Jiesi Feng, Scott F. Owen, Yichen Luo, Funing Li, Huan Wang, Takashi Yamaguchi, Zihao Yong, Yijing Gao, Wanling Peng, Lizhao Wang, Siyu Zhang, Jiulin Du, Dayu Lin, Min Xu, Anatol C. Kreitzer, Guohong Cui, Yulong Li
      Pages: 481 - 496.e19
      Abstract: The development of GPCR-activation-based-DA (GRABDA) sensors enables measurements of dopamine dynamics in freely behaving animals with high spatiotemporal precision.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.042
      Issue No: Vol. 174, No. 2 (2018)
       
  • The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
    • Authors: Christine A. Olson; Helen E. Vuong, Jessica M. Yano, Qingxing Y. Liang, David J. Nusbaum, Elaine Y. Hsiao
      First page: 497
      Abstract: (Cell 173, 1728–1741.e1–e6; June 14, 2018)
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.051
      Issue No: Vol. 174, No. 2 (2018)
       
  • SnapShot: Messenger RNA Modifications
    • Authors: Veronica Davalos; Sandra Blanco, Manel Esteller
      Pages: 498 - 498.e1
      Abstract: mRNA modifications are defining a novel layer of complexity that is becoming widely appreciated as the epitranscriptome. This SnapShot summarizes the major breakthroughs in the burgeoning field of mRNA modifications to provide an overview of the molecular players involved and insights gained into the functional consequences of the growing number of modifications occurring within mRNA transcripts.
      Citation: Cell 174, 2 (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.046
      Issue No: Vol. 174, No. 2 (2018)
       
  • Toward Minimal Residual Disease-Directed Therapy in Melanoma
    • Authors: Florian Rambow; Aljosja Rogiers, Oskar Marin-Bejar, Sara Aibar, Julia Femel, Michael Dewaele, Panagiotis Karras, Daniel Brown, Young Hwan Chang, Maria Debiec-Rychter, Carmen Adriaens, Enrico Radaelli, Pascal Wolter, Oliver Bechter, Reinhard Dummer, Mitchell Levesque, Adriano Piris, Dennie T. Frederick, Genevieve Boland, Keith T. Flaherty, Joost van den Oord, Thierry Voet, Stein Aerts, Amanda W. Lund, Jean-Christophe Marine
      Abstract: Drug-tolerant cells that persist through treatment of melanoma exhibit multiple transcriptional states, one of which is a key driver that can be targeted therapeutically.
      Citation: Cell (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.025
       
  • Turbulence Activates Platelet Biogenesis to Enable Clinical Scale
           Ex Vivo Production
    • Authors: Yukitaka Ito; Sou Nakamura, Naoshi Sugimoto, Tomohiro Shigemori, Yoshikazu Kato, Mikiko Ohno, Shinya Sakuma, Keitaro Ito, Hiroki Kumon, Hidenori Hirose, Haruki Okamoto, Masayuki Nogawa, Mio Iwasaki, Shunsuke Kihara, Kosuke Fujio, Takuya Matsumoto, Natsumi Higashi, Kazuya Hashimoto, Akira Sawaguchi, Ken-ichi Harimoto, Masato Nakagawa, Takuya Yamamoto, Makoto Handa, Naohide Watanabe, Eiichiro Nishi, Fumihito Arai, Satoshi Nishimura, Koji Eto
      Abstract: Clinical-scale generation of platelets from human-induced pluripotent stem cells can be achieved in bioreactors when turbulence is factored in as an important physical regulator of thrombopoiesis.
      Citation: Cell (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.011
       
  • Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo
           Signaling Levels
    • Authors: Adrián Cárdenas; Ana Villalba, Camino de Juan Romero, Esther Picó, Christina Kyrousi, Athanasia C. Tzika, Marc Tessier-Lavigne, Le Ma, Micha Drukker, Silvia Cappello, Víctor Borrell
      Abstract: Levels of Robo and Notch signaling across amniotes determines their predominant mode of neurogenesis, with consequences on final cerebral cortex size and complexity
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.06.007
       
  • A Molecular Grammar Governing the Driving Forces for Phase Separation of
           Prion-like RNA Binding Proteins
    • Authors: Jie Wang; Jeong-Mo Choi, Alex S. Holehouse, Hyun O. Lee, Xiaojie Zhang, Marcus Jahnel, Shovamayee Maharana, Régis Lemaitre, Andrei Pozniakovsky, David Drechsel, Ina Poser, Rohit V. Pappu, Simon Alberti, Anthony A. Hyman
      Abstract: The phase-separation behavior of FUS family proteins can be predicted by the prevalence and position of specific amino acids.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.06.006
       
  • Defects in the Alternative Splicing-Dependent Regulation of REST Cause
           Deafness
    • Authors: Yoko Nakano; Michael C. Kelly, Atteeq U. Rehman, Erich T. Boger, Robert J. Morell, Matthew W. Kelley, Thomas B. Friedman, Botond Bánfi
      Abstract: A REST mutation impacting its alternative splicing disrupts gene expression in auditory hair cells, leading to deafness, and targeting REST’s partners with HDAC inhibitors can rescue hearing in Rest mutant mice.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.06.004
       
  • Recovering Gene Interactions from Single-Cell Data Using Data Diffusion
    • Authors: David van Dijk; Roshan Sharma, Juozas Nainys, Kristina Yim, Pooja Kathail, Ambrose J. Carr, Cassandra Burdziak, Kevin R. Moon, Christine L. Chaffer, Diwakar Pattabiraman, Brian Bierie, Linas Mazutis, Guy Wolf, Smita Krishnaswamy, Dana Pe’er
      Abstract: A new algorithm overcomes limitations of data loss in single-cell sequencing experiments.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.05.061
       
  • Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor
           Microenvironment
    • Authors: Elham Azizi; Ambrose J. Carr, George Plitas, Andrew E. Cornish, Catherine Konopacki, Sandhya Prabhakaran, Juozas Nainys, Kenmin Wu, Vaidotas Kiseliovas, Manu Setty, Kristy Choi, Rachel M. Fromme, Phuong Dao, Peter T. McKenney, Ruby C. Wasti, Krishna Kadaveru, Linas Mazutis, Alexander Y. Rudensky, Dana Pe’er
      Abstract: Single-cell analysis of the breast tumor immune microenvironment, coupled with computational analysis, yields an immune map of breast cancer that points to continuous T cell activation and differentiation states.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.05.060
       
  • Direct Visualization of the Conformational Dynamics of Single Influenza
           Hemagglutinin Trimers
    • Authors: Dibyendu Kumar Das; Ramesh Govindan, Ivana Nikić-Spiegel, Florian Krammer, Edward A. Lemke, James B. Munro
      Abstract: Single-molecule FRET is used to provide real-time visualization of influenza hemagglutinin conformational dynamics on the viral surface during triggering by low pH.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.05.050
       
  • LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint
           Blockade
    • Authors: Wanqiang Sheng; Martin W. LaFleur, Thao H. Nguyen, Sujun Chen, Ankur Chakravarthy, Jake Ryan Conway, Ying Li, Hao Chen, Henry Yang, Pang-Hung Hsu, Eliezer M. Van Allen, Gordon J. Freeman, Daniel D. De Carvalho, Housheng Hansen He, Arlene H. Sharpe, Yang Shi
      Abstract: Ablating the histone demethylase LSD1 genetically or pharmacologically enhances tumor immunogenicity by stimulating endogenous retrovirus expression and downregulating RNA-induced silencing complex, supporting the promise of LSD1 inhibition in overcoming resistance to checkpoint blockade in cancer treatment.
      Citation: Cell (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.cell.2018.05.052
       
  • The Inner Nuclear Membrane Is a Metabolically Active Territory that
           Generates Nuclear Lipid Droplets
    • Authors: Anete Romanauska; Alwin Köhler
      Abstract: Active lipid metabolism and a distinct lipid composition of the inner nuclear membrane allow cells to produce nuclear lipid droplets.
      Citation: Cell (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.cell.2018.05.047
       
  • A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
    • Authors: Kristofer Davie; Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aerts
      Abstract: A single-cell atlas of adult fly brains identifies the ensemble of neuronal and glial cell types and their dynamic changes during aging.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.057
       
  • Phenotypic Convergence: Distinct Transcription Factors Regulate Common
           Terminal Features
    • Authors: Nikolaos Konstantinides; Katarina Kapuralin, Chaimaa Fadil, Luendreo Barboza, Rahul Satija, Claude Desplan
      Abstract: A single-cell analysis of the fly optic lobe reveals extensive phenotypic convergence with different sets of transcription factors, promoting similar outcomes in different cell types.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.021
       
  • Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the
           Nucleus
    • Authors: Sofia A. Quinodoz; Noah Ollikainen, Barbara Tabak, Ali Palla, Jan Marten Schmidt, Elizabeth Detmar, Mason M. Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, Erik Aznauryan, Pamela Russell, Christine Cheng, Marko Jovanovic, Amy Chow, Long Cai, Patrick McDonel, Manuel Garber, Mitchell Guttman
      Abstract: SPRITE enables genome-wide detection of multiple simultaneously occurring higher-order DNA interactions within the nucleus and provides a global picture of inter-chromosomal spatial arrangement around nuclear bodies.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.024
       
  • Immunomimetic Designer Cells Protect Mice from MRSA Infection
    • Authors: Ying Liu; Peng Bai, Anne-Kathrin Woischnig, Ghislaine Charpin-El Hamri, Haifeng Ye, Marc Folcher, Mingqi Xie, Nina Khanna, Martin Fussenegger
      First page: 259
      Abstract: Encapsulated mammalian cells with a synthetic gene circuit to sense and respond to MRSA infection could provide potential prophylactic, diagnostic, or therapeutic options for medical implant-associated infections.
      Citation: Cell (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.cell.2018.05.039
       
  • A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal
           Remodeling
    • Authors: Christoph Schneider; Claire E. O’Leary, Jakob von Moltke, Hong-Erh Liang, Qi Yan Ang, Peter J. Turnbaugh, Sridhar Radhakrishnan, Michael Pellizzon, Averil Ma, Richard M. Locksley
      First page: 271
      Abstract: Succinate produced by mutualistic colonizing protozoa activates a small intestinal tuft cell-ILC2 circuit, leading to adaptive remodeling that facilitates energy homeostasis and infection resistance in the host and a reproductive niche for the pathosymbiont.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.014
       
  • TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the
           Distinctive Fat-Treg Phenotype
    • Authors: Chaoran Li; Joanna R. DiSpirito, David Zemmour, Raul German Spallanzani, Wilson Kuswanto, Christophe Benoist, Diane Mathis
      First page: 285
      Abstract: The accumulation of regulatory T cells in visceral adipose tissue is the result of molecular and microenvironmental cues that drive cellular activation in the spleen, egress from lymphoid tissues, and final diversification in adipose tissue.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.004
       
  • Structural Basis of Smoothened Activation in Hedgehog Signaling
    • Authors: Pengxiang Huang; Sanduo Zheng, Bradley M. Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C. Kruse, Adrian Salic
      First page: 312
      Abstract: Crystal structures of sterol-bound Smoothened molecules reveal active conformations reminiscent of other classes of G-protein-coupled receptors.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.04.029
       
  • A Flat BAR Protein Promotes Actin Polymerization at the Base of
           Clathrin-Coated Pits
    • Authors: Leonardo Almeida-Souza; Rene A.W. Frank, Javier García-Nafría, Adeline Colussi, Nushan Gunawardana, Christopher M. Johnson, Minmin Yu, Gillian Howard, Byron Andrews, Yvonne Vallis, Harvey T. McMahon
      First page: 325
      Abstract: A flat BAR protein binds to the membrane surrounding clathrin-coated pits and promotes actin polymerization to aid endocytic vesicle maturation.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.020
       
  • mTORC1 Controls Phase Separation and the Biophysical Properties of the
           Cytoplasm by Tuning Crowding
    • Authors: M. Delarue; G.P. Brittingham, S. Pfeffer, I.V. Surovtsev, S. Pinglay, K.J. Kennedy, M. Schaffer, J.I. Gutierrez, D. Sang, G. Poterewicz, J.K. Chung, J.M. Plitzko, J.T. Groves, C. Jacobs-Wagner, B.D. Engel, L.J. Holt
      First page: 338
      Abstract: mTORC1 signaling controls phase transitions in the cytoplasm through its effects on molecular crowding.
      Citation: Cell (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.cell.2018.05.042
       
  • A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain
    • Authors: Benjamin Kleaveland; Charlie Y. Shi, Joanna Stefano, David P. Bartel
      First page: 350
      Abstract: Three different classes of noncoding RNA converge in a regulatory network whereby a long noncoding RNA represses a microRNA via target-directed microRNA degradation, which in turn enables the accumulation of a circular RNA in the mouse brain.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.022
       
  • Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron
           seqFISH
    • Authors: Sheel Shah; Yodai Takei, Wen Zhou, Eric Lubeck, Jina Yun, Chee-Huat Linus Eng, Noushin Koulena, Christopher Cronin, Christoph Karp, Eric J. Liaw, Mina Amin, Long Cai
      First page: 363
      Abstract: Development of intron seqFISH allows in situ profiling and visualization of nascent transcription at the single-cell level, revealing spatial and temporal features of nascent transcriptome.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.035
       
  • High-Throughput Investigation of Diverse Junction Elements in RNA Tertiary
           Folding
    • Authors: Sarah Knight Denny; Namita Bisaria, Joseph David Yesselman, Rhiju Das, Daniel Herschlag, William James Greenleaf
      First page: 377
      Abstract: Characterizing the thermodynamic fingerprints of >1,000 RNA junctions reveals principles for how RNA sequence affects tertiary assembly energetics, highlighting a path toward tertiary folding prediction by integrating static structural and dynamic energetic information.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.05.038
       
  • A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity
    • Authors: Michelle Percharde; Chih-Jen Lin, Yafei Yin, Juan Guan, Gabriel A. Peixoto, Aydan Bulut-Karslioglu, Steffen Biechele, Bo Huang, Xiaohua Shen, Miguel Ramalho-Santos
      First page: 391
      Abstract: RNA transcribed from LINE1 elements acts as a nuclear scaffold to direct gene expression programs essential for ESC self-renewal and pre-implantation embryo development.
      Citation: Cell (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.cell.2018.05.043
       
  • SMCHD1 Merges Chromosome Compartments and Assists Formation of
           Super-Structures on the Inactive X
    • Authors: Chen-Yu Wang; Teddy Jégu, Hsueh-Ping Chu, Hyun Jung Oh, Jeannie T. Lee
      First page: 406
      Abstract: Mammalian X inactivation relies on stepwise folding of chromosome compartments.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.007
       
  • A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding
           Driver in Advanced Prostate Cancer
    • Authors: David Y. Takeda; Sándor Spisák, Ji-Heui Seo, Connor Bell, Edward O’Connor, Keegan Korthauer, Dezső Ribli, István Csabai, Norbert Solymosi, Zoltán Szállási, David R. Stillman, Paloma Cejas, Xintao Qiu, Henry W. Long, Viktória Tisza, Pier Vitale Nuzzo, Mersedeh Rohanizadegan, Mark M. Pomerantz, William C. Hahn, Matthew L. Freedman
      First page: 422
      Abstract: Activation and amplification of an enhancer upstream of the androgen receptor locus drives progression of metastatic castration-resistant prostate cancer.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.037
       
  • Structural Alterations Driving Castration-Resistant Prostate Cancer
           Revealed by Linked-Read Genome Sequencing
    • Authors: Srinivas R. Viswanathan; Gavin Ha, Andreas M. Hoff, Jeremiah A. Wala, Jian Carrot-Zhang, Christopher W. Whelan, Nicholas J. Haradhvala, Samuel S. Freeman, Sarah C. Reed, Justin Rhoades, Paz Polak, Michelle Cipicchio, Stephanie A. Wankowicz, Alicia Wong, Tushar Kamath, Zhenwei Zhang, Gregory J. Gydush, Denisse Rotem, PCF/SU2C International Prostate Cancer Dream Team, J. Christopher Love, Gad Getz, Stacey Gabriel, Cheng-Zhong Zhang, Scott M. Dehm, Peter S. Nelson, Eliezer M. Van Allen, Atish D. Choudhury, Viktor A. Adalsteinsson, Rameen Beroukhim, Mary-Ellen Taplin, Matthew Meyerson
      First page: 433
      Abstract: Linked-read genome sequencing data from patients highlight that amplification of an enhancer upstream of the androgen receptor locus is a key feature of metastatic castration-resistant prostate cancer.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.036
       
 
 
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