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Cell
Journal Prestige (SJR): 25.137

Citation Impact (citeScore): 22
Number of Followers: 960

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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier

[3162 journals]

Finding Genetic Regulators, Forecasting Function
- Authors: Lara Szewczak
  First page: 247
  Abstract: The advent of whole-genome sequencing promised, among other things, that variants affecting regulatory regions of the genome could be identified to provide insight into inherited pathologies or the impact of de novo mutations. These gains are accruing but still lag expectations. While whole-genome sequences accumulate in both academic and clinical settings, one inescapable limitation is that identifying functional regulatory sequences—be they enhancers, promoters, UTRs—that control specific genes remains difficult at the level of basic research.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.043
  Issue No: Vol. 174, No. 2 (2018)
The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis
- Authors: Yoku Hayakawa; Timothy C. Wang
  Pages: 251 - 253
  Abstract: The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.037
  Issue No: Vol. 174, No. 2 (2018)
Translating the Physical Code of Life
- Authors: Benjamin D. Knapp; Kerwyn Casey Huang
  Pages: 253 - 255
  Abstract: The cytoplasm is a highly crowded and complex environment, and the regulation of its physical properties has only recently begun to be revealed. In this issue of Cell, Delarue et al. demonstrate that the control of ribosome concentration through mTORC1 sets limits on the diffusion of large particles and controls phase separation in eukaryotic cells.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.050
  Issue No: Vol. 174, No. 2 (2018)
An Algal Greening of Land
- Authors: William F. Martin; John F. Allen
  Pages: 256 - 258
  Abstract: Photosynthetic eukaryotes arose ∼1.5 billion years ago by endosymbiosis with a cyanobacterium. Algae then evolved for a billion years before one lineage finally colonized land. Why the wait' The Chara braunii genome details a decisive step linking plant origins with Earth’s history.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.034
  Issue No: Vol. 174, No. 2 (2018)
Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of
Immune Surveillance
- Authors: Wen Zhou; Aaron T. Whiteley, Carina C. de Oliveira Mann, Benjamin R. Morehouse, Radosław P. Nowak, Eric S. Fischer, Nathanael S. Gray, John J. Mekalanos, Philip J. Kranzusch
  Pages: 300 - 311.e11
  Abstract: The structure of the human cGAS–DNA complex reveals regulatory adaptations that balance enzymatic activity with DNA-length sensitivity, and additional features important for drug design.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.026
  Issue No: Vol. 174, No. 2 (2018)
The Chara Genome: Secondary Complexity and Implications for Plant
Terrestrialization
- Authors: Tomoaki Nishiyama; Hidetoshi Sakayama, Jan de Vries, Henrik Buschmann, Denis Saint-Marcoux, Kristian K. Ullrich, Fabian B. Haas, Lisa Vanderstraeten, Dirk Becker, Daniel Lang, Stanislav Vosolsobě, Stephane Rombauts, Per K.I. Wilhelmsson, Philipp Janitza, Ramona Kern, Alexander Heyl, Florian Rümpler, Luz Irina A. Calderón Villalobos, John M. Clay, Roman Skokan, Atsushi Toyoda, Yutaka Suzuki, Hiroshi Kagoshima, Elio Schijlen, Navindra Tajeshwar, Bruno Catarino, Alexander J. Hetherington, Assia Saltykova, Clemence Bonnot, Holger Breuninger, Aikaterini Symeonidi, Guru V. Radhakrishnan, Filip Van Nieuwerburgh, Dieter Deforce, Caren Chang, Kenneth G. Karol, Rainer Hedrich, Peter Ulvskov, Gernot Glöckner, Charles F. Delwiche, Jan Petrášek, Yves Van de Peer, Jiri Friml, Mary Beilby, Liam Dolan, Yuji Kohara, Sumio Sugano, Asao Fujiyama, Pierre-Marc Delaux, Marcel Quint, Günter Theißen, Martin Hagemann, Jesper Harholt, Christophe Dunand, Sabine Zachgo, Jane Langdale, Florian Maumus, Dominique Van Der Straeten, Sven B. Gould, Stefan A. Rensing
  Pages: 448 - 464.e24
  Abstract: The draft genome of Chara braunii reveals many plant-like features important for colonization of land that evolved in charophytic algae and therefore prior to the earliest land plants.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.033
  Issue No: Vol. 174, No. 2 (2018)
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced
Brain-Cell-Type Targeting and Functionality
- Authors: Tanya L. Daigle; Linda Madisen, Travis A. Hage, Matthew T. Valley, Ulf Knoblich, Rylan S. Larsen, Marc M. Takeno, Lawrence Huang, Hong Gu, Rachael Larsen, Maya Mills, Alice Bosma-Moody, La’ Akea Siverts, Miranda Walker, Lucas T. Graybuck, Zizhen Yao, Olivia Fong, Thuc Nghi Nguyen, Emma Garren, Garreck H. Lenz, Mariya Chavarha, Julie Pendergraft, James Harrington, Karla E. Hirokawa, Julie A. Harris, Philip R. Nicovich, Medea J. McGraw, Douglas R. Ollerenshaw, Kimberly A. Smith, Christopher A. Baker, Jonathan T. Ting, Susan M. Sunkin, Jérôme Lecoq, Michael Z. Lin, Edward S. Boyden, Gabe J. Murphy, Nuno M. da Costa, Jack Waters, Lu Li, Bosiljka Tasic, Hongkui Zeng
  Pages: 465 - 480.e22
  Abstract: An expanded toolkit of transgenic mouse lines for exploring the organization, function, and development of mammalian neural circuits.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.035
  Issue No: Vol. 174, No. 2 (2018)
A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific
Detection of Dopamine in Flies, Fish, and Mice
- Authors: Fangmiao Sun; Jianzhi Zeng, Miao Jing, Jingheng Zhou, Jiesi Feng, Scott F. Owen, Yichen Luo, Funing Li, Huan Wang, Takashi Yamaguchi, Zihao Yong, Yijing Gao, Wanling Peng, Lizhao Wang, Siyu Zhang, Jiulin Du, Dayu Lin, Min Xu, Anatol C. Kreitzer, Guohong Cui, Yulong Li
  Pages: 481 - 496.e19
  Abstract: The development of GPCR-activation-based-DA (GRABDA) sensors enables measurements of dopamine dynamics in freely behaving animals with high spatiotemporal precision.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.042
  Issue No: Vol. 174, No. 2 (2018)
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
- Authors: Christine A. Olson; Helen E. Vuong, Jessica M. Yano, Qingxing Y. Liang, David J. Nusbaum, Elaine Y. Hsiao
  First page: 497
  Abstract: (Cell 173, 1728–1741.e1–e6; June 14, 2018)
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.051
  Issue No: Vol. 174, No. 2 (2018)
SnapShot: Messenger RNA Modifications
- Authors: Veronica Davalos; Sandra Blanco, Manel Esteller
  Pages: 498 - 498.e1
  Abstract: mRNA modifications are defining a novel layer of complexity that is becoming widely appreciated as the epitranscriptome. This SnapShot summarizes the major breakthroughs in the burgeoning field of mRNA modifications to provide an overview of the molecular players involved and insights gained into the functional consequences of the growing number of modifications occurring within mRNA transcripts.
  Citation: Cell 174, 2 (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.046
  Issue No: Vol. 174, No. 2 (2018)
Toward Minimal Residual Disease-Directed Therapy in Melanoma
- Authors: Florian Rambow; Aljosja Rogiers, Oskar Marin-Bejar, Sara Aibar, Julia Femel, Michael Dewaele, Panagiotis Karras, Daniel Brown, Young Hwan Chang, Maria Debiec-Rychter, Carmen Adriaens, Enrico Radaelli, Pascal Wolter, Oliver Bechter, Reinhard Dummer, Mitchell Levesque, Adriano Piris, Dennie T. Frederick, Genevieve Boland, Keith T. Flaherty, Joost van den Oord, Thierry Voet, Stein Aerts, Amanda W. Lund, Jean-Christophe Marine
  Abstract: Drug-tolerant cells that persist through treatment of melanoma exhibit multiple transcriptional states, one of which is a key driver that can be targeted therapeutically.
  Citation: Cell (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.025
Turbulence Activates Platelet Biogenesis to Enable Clinical Scale
Ex Vivo Production
- Authors: Yukitaka Ito; Sou Nakamura, Naoshi Sugimoto, Tomohiro Shigemori, Yoshikazu Kato, Mikiko Ohno, Shinya Sakuma, Keitaro Ito, Hiroki Kumon, Hidenori Hirose, Haruki Okamoto, Masayuki Nogawa, Mio Iwasaki, Shunsuke Kihara, Kosuke Fujio, Takuya Matsumoto, Natsumi Higashi, Kazuya Hashimoto, Akira Sawaguchi, Ken-ichi Harimoto, Masato Nakagawa, Takuya Yamamoto, Makoto Handa, Naohide Watanabe, Eiichiro Nishi, Fumihito Arai, Satoshi Nishimura, Koji Eto
  Abstract: Clinical-scale generation of platelets from human-induced pluripotent stem cells can be achieved in bioreactors when turbulence is factored in as an important physical regulator of thrombopoiesis.
  Citation: Cell (2018)
  PubDate: 2018-07-12
  DOI: 10.1016/j.cell.2018.06.011
Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo
Signaling Levels
- Authors: Adrián Cárdenas; Ana Villalba, Camino de Juan Romero, Esther Picó, Christina Kyrousi, Athanasia C. Tzika, Marc Tessier-Lavigne, Le Ma, Micha Drukker, Silvia Cappello, Víctor Borrell
  Abstract: Levels of Robo and Notch signaling across amniotes determines their predominant mode of neurogenesis, with consequences on final cerebral cortex size and complexity
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.06.007
A Molecular Grammar Governing the Driving Forces for Phase Separation of
Prion-like RNA Binding Proteins
- Authors: Jie Wang; Jeong-Mo Choi, Alex S. Holehouse, Hyun O. Lee, Xiaojie Zhang, Marcus Jahnel, Shovamayee Maharana, Régis Lemaitre, Andrei Pozniakovsky, David Drechsel, Ina Poser, Rohit V. Pappu, Simon Alberti, Anthony A. Hyman
  Abstract: The phase-separation behavior of FUS family proteins can be predicted by the prevalence and position of specific amino acids.
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.06.006
Defects in the Alternative Splicing-Dependent Regulation of REST Cause
Deafness
- Authors: Yoko Nakano; Michael C. Kelly, Atteeq U. Rehman, Erich T. Boger, Robert J. Morell, Matthew W. Kelley, Thomas B. Friedman, Botond Bánfi
  Abstract: A REST mutation impacting its alternative splicing disrupts gene expression in auditory hair cells, leading to deafness, and targeting REST’s partners with HDAC inhibitors can rescue hearing in Rest mutant mice.
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.06.004
Recovering Gene Interactions from Single-Cell Data Using Data Diffusion
- Authors: David van Dijk; Roshan Sharma, Juozas Nainys, Kristina Yim, Pooja Kathail, Ambrose J. Carr, Cassandra Burdziak, Kevin R. Moon, Christine L. Chaffer, Diwakar Pattabiraman, Brian Bierie, Linas Mazutis, Guy Wolf, Smita Krishnaswamy, Dana Pe’er
  Abstract: A new algorithm overcomes limitations of data loss in single-cell sequencing experiments.
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.05.061
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor
Microenvironment
- Authors: Elham Azizi; Ambrose J. Carr, George Plitas, Andrew E. Cornish, Catherine Konopacki, Sandhya Prabhakaran, Juozas Nainys, Kenmin Wu, Vaidotas Kiseliovas, Manu Setty, Kristy Choi, Rachel M. Fromme, Phuong Dao, Peter T. McKenney, Ruby C. Wasti, Krishna Kadaveru, Linas Mazutis, Alexander Y. Rudensky, Dana Pe’er
  Abstract: Single-cell analysis of the breast tumor immune microenvironment, coupled with computational analysis, yields an immune map of breast cancer that points to continuous T cell activation and differentiation states.
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.05.060
Direct Visualization of the Conformational Dynamics of Single Influenza
Hemagglutinin Trimers
- Authors: Dibyendu Kumar Das; Ramesh Govindan, Ivana Nikić-Spiegel, Florian Krammer, Edward A. Lemke, James B. Munro
  Abstract: Single-molecule FRET is used to provide real-time visualization of influenza hemagglutinin conformational dynamics on the viral surface during triggering by low pH.
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.05.050
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint
Blockade
- Authors: Wanqiang Sheng; Martin W. LaFleur, Thao H. Nguyen, Sujun Chen, Ankur Chakravarthy, Jake Ryan Conway, Ying Li, Hao Chen, Henry Yang, Pang-Hung Hsu, Eliezer M. Van Allen, Gordon J. Freeman, Daniel D. De Carvalho, Housheng Hansen He, Arlene H. Sharpe, Yang Shi
  Abstract: Ablating the histone demethylase LSD1 genetically or pharmacologically enhances tumor immunogenicity by stimulating endogenous retrovirus expression and downregulating RNA-induced silencing complex, supporting the promise of LSD1 inhibition in overcoming resistance to checkpoint blockade in cancer treatment.
  Citation: Cell (2018)
  PubDate: 2018-06-21
  DOI: 10.1016/j.cell.2018.05.052
The Inner Nuclear Membrane Is a Metabolically Active Territory that
Generates Nuclear Lipid Droplets
- Authors: Anete Romanauska; Alwin Köhler
  Abstract: Active lipid metabolism and a distinct lipid composition of the inner nuclear membrane allow cells to produce nuclear lipid droplets.
  Citation: Cell (2018)
  PubDate: 2018-06-21
  DOI: 10.1016/j.cell.2018.05.047
A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
- Authors: Kristofer Davie; Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aerts
  Abstract: A single-cell atlas of adult fly brains identifies the ensemble of neuronal and glial cell types and their dynamic changes during aging.
  Citation: Cell (2018)
  PubDate: 2018-06-14
  DOI: 10.1016/j.cell.2018.05.057
Phenotypic Convergence: Distinct Transcription Factors Regulate Common
Terminal Features
- Authors: Nikolaos Konstantinides; Katarina Kapuralin, Chaimaa Fadil, Luendreo Barboza, Rahul Satija, Claude Desplan
  Abstract: A single-cell analysis of the fly optic lobe reveals extensive phenotypic convergence with different sets of transcription factors, promoting similar outcomes in different cell types.
  Citation: Cell (2018)
  PubDate: 2018-06-14
  DOI: 10.1016/j.cell.2018.05.021
Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the
Nucleus
- Authors: Sofia A. Quinodoz; Noah Ollikainen, Barbara Tabak, Ali Palla, Jan Marten Schmidt, Elizabeth Detmar, Mason M. Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, Erik Aznauryan, Pamela Russell, Christine Cheng, Marko Jovanovic, Amy Chow, Long Cai, Patrick McDonel, Manuel Garber, Mitchell Guttman
  Abstract: SPRITE enables genome-wide detection of multiple simultaneously occurring higher-order DNA interactions within the nucleus and provides a global picture of inter-chromosomal spatial arrangement around nuclear bodies.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.024
Immunomimetic Designer Cells Protect Mice from MRSA Infection
- Authors: Ying Liu; Peng Bai, Anne-Kathrin Woischnig, Ghislaine Charpin-El Hamri, Haifeng Ye, Marc Folcher, Mingqi Xie, Nina Khanna, Martin Fussenegger
  First page: 259
  Abstract: Encapsulated mammalian cells with a synthetic gene circuit to sense and respond to MRSA infection could provide potential prophylactic, diagnostic, or therapeutic options for medical implant-associated infections.
  Citation: Cell (2018)
  PubDate: 2018-06-21
  DOI: 10.1016/j.cell.2018.05.039
A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal
Remodeling
- Authors: Christoph Schneider; Claire E. O’Leary, Jakob von Moltke, Hong-Erh Liang, Qi Yan Ang, Peter J. Turnbaugh, Sridhar Radhakrishnan, Michael Pellizzon, Averil Ma, Richard M. Locksley
  First page: 271
  Abstract: Succinate produced by mutualistic colonizing protozoa activates a small intestinal tuft cell-ILC2 circuit, leading to adaptive remodeling that facilitates energy homeostasis and infection resistance in the host and a reproductive niche for the pathosymbiont.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.014
TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the
Distinctive Fat-Treg Phenotype
- Authors: Chaoran Li; Joanna R. DiSpirito, David Zemmour, Raul German Spallanzani, Wilson Kuswanto, Christophe Benoist, Diane Mathis
  First page: 285
  Abstract: The accumulation of regulatory T cells in visceral adipose tissue is the result of molecular and microenvironmental cues that drive cellular activation in the spleen, egress from lymphoid tissues, and final diversification in adipose tissue.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.004
Structural Basis of Smoothened Activation in Hedgehog Signaling
- Authors: Pengxiang Huang; Sanduo Zheng, Bradley M. Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C. Kruse, Adrian Salic
  First page: 312
  Abstract: Crystal structures of sterol-bound Smoothened molecules reveal active conformations reminiscent of other classes of G-protein-coupled receptors.
  Citation: Cell (2018)
  PubDate: 2018-05-24
  DOI: 10.1016/j.cell.2018.04.029
A Flat BAR Protein Promotes Actin Polymerization at the Base of
Clathrin-Coated Pits
- Authors: Leonardo Almeida-Souza; Rene A.W. Frank, Javier García-Nafría, Adeline Colussi, Nushan Gunawardana, Christopher M. Johnson, Minmin Yu, Gillian Howard, Byron Andrews, Yvonne Vallis, Harvey T. McMahon
  First page: 325
  Abstract: A flat BAR protein binds to the membrane surrounding clathrin-coated pits and promotes actin polymerization to aid endocytic vesicle maturation.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.020
mTORC1 Controls Phase Separation and the Biophysical Properties of the
Cytoplasm by Tuning Crowding
- Authors: M. Delarue; G.P. Brittingham, S. Pfeffer, I.V. Surovtsev, S. Pinglay, K.J. Kennedy, M. Schaffer, J.I. Gutierrez, D. Sang, G. Poterewicz, J.K. Chung, J.M. Plitzko, J.T. Groves, C. Jacobs-Wagner, B.D. Engel, L.J. Holt
  First page: 338
  Abstract: mTORC1 signaling controls phase transitions in the cytoplasm through its effects on molecular crowding.
  Citation: Cell (2018)
  PubDate: 2018-06-21
  DOI: 10.1016/j.cell.2018.05.042
A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain
- Authors: Benjamin Kleaveland; Charlie Y. Shi, Joanna Stefano, David P. Bartel
  First page: 350
  Abstract: Three different classes of noncoding RNA converge in a regulatory network whereby a long noncoding RNA represses a microRNA via target-directed microRNA degradation, which in turn enables the accumulation of a circular RNA in the mouse brain.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.022
Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron
seqFISH
- Authors: Sheel Shah; Yodai Takei, Wen Zhou, Eric Lubeck, Jina Yun, Chee-Huat Linus Eng, Noushin Koulena, Christopher Cronin, Christoph Karp, Eric J. Liaw, Mina Amin, Long Cai
  First page: 363
  Abstract: Development of intron seqFISH allows in situ profiling and visualization of nascent transcription at the single-cell level, revealing spatial and temporal features of nascent transcriptome.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.035
High-Throughput Investigation of Diverse Junction Elements in RNA Tertiary
Folding
- Authors: Sarah Knight Denny; Namita Bisaria, Joseph David Yesselman, Rhiju Das, Daniel Herschlag, William James Greenleaf
  First page: 377
  Abstract: Characterizing the thermodynamic fingerprints of >1,000 RNA junctions reveals principles for how RNA sequence affects tertiary assembly energetics, highlighting a path toward tertiary folding prediction by integrating static structural and dynamic energetic information.
  Citation: Cell (2018)
  PubDate: 2018-06-28
  DOI: 10.1016/j.cell.2018.05.038
A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity
- Authors: Michelle Percharde; Chih-Jen Lin, Yafei Yin, Juan Guan, Gabriel A. Peixoto, Aydan Bulut-Karslioglu, Steffen Biechele, Bo Huang, Xiaohua Shen, Miguel Ramalho-Santos
  First page: 391
  Abstract: RNA transcribed from LINE1 elements acts as a nuclear scaffold to direct gene expression programs essential for ESC self-renewal and pre-implantation embryo development.
  Citation: Cell (2018)
  PubDate: 2018-06-21
  DOI: 10.1016/j.cell.2018.05.043
SMCHD1 Merges Chromosome Compartments and Assists Formation of
Super-Structures on the Inactive X
- Authors: Chen-Yu Wang; Teddy Jégu, Hsueh-Ping Chu, Hyun Jung Oh, Jeannie T. Lee
  First page: 406
  Abstract: Mammalian X inactivation relies on stepwise folding of chromosome compartments.
  Citation: Cell (2018)
  PubDate: 2018-06-07
  DOI: 10.1016/j.cell.2018.05.007
A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding
Driver in Advanced Prostate Cancer
- Authors: David Y. Takeda; Sándor Spisák, Ji-Heui Seo, Connor Bell, Edward O’Connor, Keegan Korthauer, Dezső Ribli, István Csabai, Norbert Solymosi, Zoltán Szállási, David R. Stillman, Paloma Cejas, Xintao Qiu, Henry W. Long, Viktória Tisza, Pier Vitale Nuzzo, Mersedeh Rohanizadegan, Mark M. Pomerantz, William C. Hahn, Matthew L. Freedman
  First page: 422
  Abstract: Activation and amplification of an enhancer upstream of the androgen receptor locus drives progression of metastatic castration-resistant prostate cancer.
  Citation: Cell (2018)
  PubDate: 2018-06-14
  DOI: 10.1016/j.cell.2018.05.037
Structural Alterations Driving Castration-Resistant Prostate Cancer
Revealed by Linked-Read Genome Sequencing
- Authors: Srinivas R. Viswanathan; Gavin Ha, Andreas M. Hoff, Jeremiah A. Wala, Jian Carrot-Zhang, Christopher W. Whelan, Nicholas J. Haradhvala, Samuel S. Freeman, Sarah C. Reed, Justin Rhoades, Paz Polak, Michelle Cipicchio, Stephanie A. Wankowicz, Alicia Wong, Tushar Kamath, Zhenwei Zhang, Gregory J. Gydush, Denisse Rotem, PCF/SU2C International Prostate Cancer Dream Team, J. Christopher Love, Gad Getz, Stacey Gabriel, Cheng-Zhong Zhang, Scott M. Dehm, Peter S. Nelson, Eliezer M. Van Allen, Atish D. Choudhury, Viktor A. Adalsteinsson, Rameen Beroukhim, Mary-Ellen Taplin, Matthew Meyerson
  First page: 433
  Abstract: Linked-read genome sequencing data from patients highlight that amplification of an enhancer upstream of the androgen receptor locus is a key feature of metastatic castration-resistant prostate cancer.
  Citation: Cell (2018)
  PubDate: 2018-06-14
  DOI: 10.1016/j.cell.2018.05.036