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Cell
Journal Prestige (SJR): 25.137  Citation Impact (citeScore): 22 Number of Followers: 1116  Subscription journalISSN (Print) 0092-8674 - ISSN (Online) 1097-4172 Published by Elsevier  [2805 journals]
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- We like neurons
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Authors: Charleese Williams
Pages: 221 - 223
Abstract: Charleese Williams is the winner of the 2021 Rising Black Scientists Award for an undergraduate scholar. For this award, we asked emerging Black scientists to tell us about the experiences that sparked their interest in the life sciences, their vision and goals, and how they want to contribute to a more inclusive scientific community. This is her story.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.019
Issue No: Vol. 185, No. 2 (2022)
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- Science as a tool for justice
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Authors: Elle Lett
Pages: 224 - 226
Abstract: Elle Lett is the winner of the 2021 Rising Black Scientists Award for a post-graduate scholar. For this award, we asked emerging Black scientists to tell us about the experiences that sparked their interest in the life sciences, their vision and goals, and how they want to contribute to a more inclusive scientific community. This is her story.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.020
Issue No: Vol. 185, No. 2 (2022)
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- The loud minority: Transcriptionally active HIV-1-infected cells survive,
proliferate, and persist-
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Authors: Jack A. Collora; Ya-Chi Ho
Pages: 227 - 229
Abstract: The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation. Understanding HIV-1-chromatin interactions and how transcriptionally active HIV-1-infected cells survive is a pressing need.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.038
Issue No: Vol. 185, No. 2 (2022)
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- One ring doesn’t rule them all: Distinct nuclear pore complexes in a
single cell-
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Authors: Megan R. McCarthy; C. Patrick Lusk
Pages: 230 - 231
Abstract: Determining the structural plasticity and dynamics of nuclear pore complexes (NPCs) are major challenges. In this issue of Cell, Akey et al. present comprehensive NPC structures from in vitro and in vivo preparations, demonstrating multiple NPC forms in single cells while providing insight into the evolutionary origin of NPC architecture.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.042
Issue No: Vol. 185, No. 2 (2022)
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- Counting protein molecules for single-cell proteomics
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Authors: Nikolai Slavov
Pages: 232 - 234
Abstract: Technologies for counting protein molecules are enabling single-cell proteomics at increasing depth and scale. New advances in single-molecule methods by Brinkerhoff and colleagues promise to further increase the sensitivity of protein analysis and motivate questions about scaling up the counting of the human proteome.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.013
Issue No: Vol. 185, No. 2 (2022)
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- Cell maturation: Hallmarks, triggers, and manipulation
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Authors: Juan R. Alvarez-Dominguez; Douglas A. Melton
Pages: 235 - 249
Abstract: Alvarez-Dominguez and Melton propose a framework for understanding cellular “maturity” that incorporates modern views on plasticity. Using this framework, they describe the known chemical and physical regulators of maturity and summarize approaches and progress in regulating maturity in experimental models and regenerative medicine.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-06
DOI: 10.1016/j.cell.2021.12.012
Issue No: Vol. 185, No. 2 (2022)
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- Engineered virus-like particles for efficient in vivo delivery of
therapeutic proteins-
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Authors: Samagya Banskota; Aditya Raguram, Susie Suh, Samuel W. Du, Jessie R. Davis, Elliot H. Choi, Xiao Wang, Sarah C. Nielsen, Gregory A. Newby, Peyton B. Randolph, Mark J. Osborn, Kiran Musunuru, Krzysztof Palczewski, David R. Liu
Pages: 250 - 265.e16
Abstract: Engineered, DNA-free virus-like particles efficiently deliver gene editing proteins, have minimal off-target effects, can be applied in vivo to deliver base editors to multiple organs, and are used to improve visual function in a mouse model of genetic blindness.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-11
DOI: 10.1016/j.cell.2021.12.021
Issue No: Vol. 185, No. 2 (2022)
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- Parallel analysis of transcription, integration, and sequence of single
HIV-1 proviruses-
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Authors: Kevin B. Einkauf; Matthew R. Osborn, Ce Gao, Weiwei Sun, Xiaoming Sun, Xiaodong Lian, Elizabeth M. Parsons, Gregory T. Gladkov, Kyra W. Seiger, Jane E. Blackmer, Chenyang Jiang, Steven A. Yukl, Eric S. Rosenberg, Xu G. Yu, Mathias Lichterfeld
Pages: 266 - 282.e15
Abstract: PRIP-seq is a multidimensional single-cell assay that simultaneously captures the proviral sequence, the corresponding chromosomal integration site, and the expression of HIV-1 RNA in single virally infected cells and allows for the global mapping of transcriptionally active and silent proviruses in patients receiving suppressive antiretroviral therapy.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-12
DOI: 10.1016/j.cell.2021.12.011
Issue No: Vol. 185, No. 2 (2022)
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- GSDMB is increased in IBD and regulates epithelial restitution/repair
independent of pyroptosis-
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Authors: Nitish Rana; Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro
Pages: 283 - 298.e17
Abstract: Independent from its established role in pyroptotic cell death, gasdermin B regulates focal adhesion kinase phosphorylation to promote epithelial maintenance and repair. Naturally occurring mutations associated with inflammatory bowel disease disrupt this role.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-11
DOI: 10.1016/j.cell.2021.12.024
Issue No: Vol. 185, No. 2 (2022)
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- Transition to invasive breast cancer is associated with progressive
changes in the structure and composition of tumor stroma-
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Authors: Tyler Risom; David R. Glass, Inna Averbukh, Candace C. Liu, Alex Baranski, Adam Kagel, Erin F. McCaffrey, Noah F. Greenwald, Belén Rivero-Gutiérrez, Siri H. Strand, Sushama Varma, Alex Kong, Leeat Keren, Sucheta Srivastava, Chunfang Zhu, Zumana Khair, Deborah J. Veis, Katherine Deschryver, Sujay Vennam, Carlo Maley, E. Shelley Hwang, Jeffrey R. Marks, Sean C. Bendall, Graham A. Colditz, Robert B. West, Michael Angelo
Pages: 299 - 310.e18
Abstract: A spatial imaging atlas of patient-matched ductal carcinoma in situ and invasive breast cancer depicts coordinated changes in the tumor microenviroment associated with invasive relapse, suggesting a potential protective role of myoepithelial disruption against invasive progression.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.023
Issue No: Vol. 185, No. 2 (2022)
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- Vision-dependent specification of cell types and function in the
developing cortex-
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Authors: Sarah Cheng; Salwan Butrus, Liming Tan, Runzhe Xu, Srikant Sagireddy, Joshua T. Trachtenberg, Karthik Shekhar, S. Lawrence Zipursky
Pages: 311 - 327.e24
Abstract: Transcriptomic, genetic, and functional analyses of the developing mouse primary visual cortex (V1) reveal that early sensory experience selectively influences the development of layer 2/3 glutamatergic neurons by regulating spatial and temporal gene expression programs.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.022
Issue No: Vol. 185, No. 2 (2022)
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- Control of mammalian locomotion by ventral spinocerebellar tract neurons
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Authors: Joshua I. Chalif; María de Lourdes Martínez-Silva, John G. Pagiazitis, Andrew J. Murray, George Z. Mentis
Pages: 328 - 344.e26
Abstract: Ventral spinocerebellar tract neurons (VSCTs) are necessary and sufficient to drive generation and maintenance of locomotor behavior in mice.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.014
Issue No: Vol. 185, No. 2 (2022)
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- Fundamental behaviors emerge from simulations of a living minimal cell
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Authors: Zane R. Thornburg; David M. Bianchi, Troy A. Brier, Benjamin R. Gilbert, Tyler M. Earnest, Marcelo C.R. Melo, Nataliya Safronova, James P. Sáenz, András T. Cook, Kim S. Wise, Clyde A. Hutchison, Hamilton O. Smith, John I. Glass, Zaida Luthey-Schulten
Pages: 345 - 360.e28
Abstract: A kinetic model for a minimal bacterial cell offers quantitative insight into how the cell balances processes from metabolism to gene expression to growth.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.025
Issue No: Vol. 185, No. 2 (2022)
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- Comprehensive structure and functional adaptations of the yeast nuclear
pore complex-
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Authors: Christopher W. Akey; Digvijay Singh, Christna Ouch, Ignacia Echeverria, Ilona Nudelman, Joseph M. Varberg, Zulin Yu, Fei Fang, Yi Shi, Junjie Wang, Daniel Salzberg, Kangkang Song, Chen Xu, James C. Gumbart, Sergey Suslov, Jay Unruh, Sue L. Jaspersen, Brian T. Chait, Andrej Sali, Javier Fernandez-Martinez, Steven J. Ludtke, Elizabeth Villa, Michael P. Rout
Pages: 361 - 378.e25
Abstract: A comprehensive model of the yeast NPC reveals an interconnected architecture of the core scaffold and provides an understanding of the isoforms and structural plasticity that may be associated with different functional states.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-03
DOI: 10.1016/j.cell.2021.12.015
Issue No: Vol. 185, No. 2 (2022)
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- Spatial proteogenomics reveals distinct and evolutionarily conserved
hepatic macrophage niches-
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Authors: Martin Guilliams; Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Gonçalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J.F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott
Pages: 379 - 396.e38
Abstract: By combining single-cell and -nucleus sequencing with spatial mapping of RNA and proteins, this vast spatial proteogenomic atlas of healthy and obese human and mouse livers presents methods to identify and localize all hepatic cells and provides insights into hepatic myeloid cells, including identification of reliable surface markers for isolation and localization of hepatic macrophages, characterization of lipid-associated macrophages in both healthy and steatotic livers, determination of a key regulatory axis of Kupffer cell development, and identification of a conserved core gene expression signature of Kupffer cells across 7 species, including chickens and zebrafish.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-11
DOI: 10.1016/j.cell.2021.12.018
Issue No: Vol. 185, No. 2 (2022)
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- Downregulation of Diacylglycerol Kinase Delta Contributes to
Hyperglycemia-Induced Insulin Resistance-
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Authors: Alexander V. Chibalin; Ying Leng, Elaine Vieira, Anna Krook, Marie Björnholm, Yun Chau Long, Olga Kotova, Zhihui Zhong, Fumio Sakane, Tatiana Steiler, Carolina Nylén, Jianjun Wang, Markku Laakso, Matthew K. Topham, Marc Gilbert, Harriet Wallberg-Henriksson, Juleen R. Zierath
Pages: 397 - 398
Abstract: (Cell 132, 375–386; February 8, 2008)
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.044
Issue No: Vol. 185, No. 2 (2022)
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- SnapShot: Human endogenous retroviruses
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Authors: Johan Jakobsson; Michelle Vincendeau
Pages: 400 - 400.e1
Abstract: Human endogenous retroviruses (HERVs) represent approximately 8% of the human genome. HERVs can function as important regulators of gene networks, thereby influencing biological processes, and their dysregulation may influence pathological processes. In this SnapShot, we provide an overview of different HERV families, how they are controlled, and their functional impact on diseases such as cancer and neurological disorders. To view this SnapShot, open or download the PDF.
Citation: Cell 185, 2 (2022)
PubDate: 2022-01-20
DOI: 10.1016/j.cell.2021.12.028
Issue No: Vol. 185, No. 2 (2022)
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