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Cell
Journal Prestige (SJR): 25.137

Citation Impact (citeScore): 22
Number of Followers: 1346

Full-text available via subscription

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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier

[3200 journals]

Beth Levine (1960–2020)
- Authors: Ramnik J. Xavier; Herbert W. Virgin
  Pages: 533 - 536
  Abstract: Beth Levine, a pioneer in the field of modern mammalian autophagy, died on June 15, 2020. Her life’s work, which bridged fundamental cellular biology and human disease, elucidated gene regulatory mechanisms of mammalian autophagy and implicated this pathway in the pathogenesis of a spectrum of diseases. Born on April 7, 1960 in Newark, New Jersey, Beth received an AB magna cum laude in French Studies from Brown University and an MD from Cornell University Medical College. She completed her internship and residency in Internal Medicine at Mount Sinai Hospital in New York City and her fellowship in Infectious Diseases at Johns Hopkins Hospital in Baltimore.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-16
  DOI: 10.1016/j.cell.2020.07.002
  Issue No: Vol. 182, No. 3 (2020)
Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor
- Authors: Claudio J. Villanueva
  Pages: 537 - 539
  Abstract: Oguri and colleagues use single-cell RNA sequencing to identify a beige adipocyte precursor cell that gives rise to thermogenic adipocytes in subcutaneous adipose tissue. These beige fat progenitors are marked by PDGFRα, Sca1, and CD81 and proliferate upon activation of FAK-signaling in response to the cold and irisin.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-08-06
  DOI: 10.1016/j.cell.2020.07.014
  Issue No: Vol. 182, No. 3 (2020)
A Hairy End to a Chilling Event
- Authors: Raluca Pascalau; Rejji Kuruvilla
  Pages: 539 - 541
  Abstract: In the skin, sympathetic nerves, arrector pili muscles, and hair follicles form a tri-lineage unit to cause piloerection or goosebumps. In this issue of Cell, Schwartz et al. report that, beyond goosebumps, muscle-anchored nerves form “synapse-like” connections with hair follicle stem cells to promote hair regeneration in response to cold.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-08-06
  DOI: 10.1016/j.cell.2020.07.004
  Issue No: Vol. 182, No. 3 (2020)
Microbial RNAs Pressure Piezo1 to Respond
- Authors: Juan D. Matute; Jinzhi Duan, Richard S. Blumberg
  Pages: 542 - 544
  Abstract: Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-08-06
  DOI: 10.1016/j.cell.2020.07.015
  Issue No: Vol. 182, No. 3 (2020)
Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart
Injury
- Authors: Tomohiro Yokota; Jackie McCourt, Feiyang Ma, Shuxun Ren, Shen Li, Tae-Hyung Kim, Yerbol Z. Kurmangaliyev, Rohollah Nasiri, Samad Ahadian, Thang Nguyen, Xing Haw Marvin Tan, Yonggang Zhou, Rimao Wu, Abraham Rodriguez, Whitaker Cohn, Yibin Wang, Julian Whitelegge, Sergey Ryazantsev, Ali Khademhosseini, Michael A. Teitell, Pei-Yu Chiou, David E. Birk, Amy C. Rowat, Rachelle H. Crosbie, Matteo Pellegrini, Marcus Seldin, Aldons J. Lusis, Arjun Deb
  Pages: 545 - 562.e23
  Abstract: Scar tissue size following heart injury is a predictor of cardiovascular outcomes. Yokota et al. find that a specific collagen, type V, plays a paradoxical role in limiting scar size by altering the mechanical properties of developing scar tissue.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-03
  DOI: 10.1016/j.cell.2020.06.030
  Issue No: Vol. 182, No. 3 (2020)
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK
Signaling
- Authors: Yasuo Oguri; Kosaku Shinoda, Hyeonwoo Kim, Diana L. Alba, W. Reid Bolus, Qiang Wang, Zachary Brown, Rachana N. Pradhan, Kazuki Tajima, Takeshi Yoneshiro, Kenji Ikeda, Yong Chen, Rachel T. Cheang, Kazuyuki Tsujino, Caroline R. Kim, Vanille Juliette Greiner, Ritwik Datta, Christopher D. Yang, Kamran Atabai, Michael T. McManus, Suneil K. Koliwad, Bruce M. Spiegelman, Shingo Kajimura
  Pages: 563 - 577.e20
  Abstract: A subset of adipocyte progenitor cells give rise to beige fat through signaling responses to irisin through the action of specific integrins and the co-receptor CD81.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-01
  DOI: 10.1016/j.cell.2020.06.021
  Issue No: Vol. 182, No. 3 (2020)
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle
Stem Cells
- Authors: Yulia Shwartz; Meryem Gonzalez-Celeiro, Chih-Lung Chen, H. Amalia Pasolli, Shu-Hsien Sheu, Sabrina Mai-Yi Fan, Farnaz Shamsi, Steven Assaad, Edrick Tai-Yu Lin, Bing Zhang, Pai-Chi Tsai, Megan He, Yu-Hua Tseng, Sung-Jan Lin, Ya-Chieh Hsu
  Pages: 578 - 593.e19
  Abstract: The arrector pili muscle and the sympathetic neuron form a dual-component niche that regulates hair follicle stem cells—the sympathetic neuron regulates stem cells directly with norepinephrine via synapse-like structures, whereas the arrector pili muscle maintains sympathetic innervation to stem cells. Through these three connected cell types, cold stimulates not only goosebumps but also stem cell activation.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-16
  DOI: 10.1016/j.cell.2020.06.031
  Issue No: Vol. 182, No. 3 (2020)
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells
- Authors: Wei Huang; Aparna Bhaduri, Dmitry Velmeshev, Shaohui Wang, Li Wang, Catherine A. Rottkamp, Arturo Alvarez-Buylla, David H. Rowitch, Arnold R. Kriegstein
  Pages: 594 - 608.e11
  Abstract: The properties of human oligodendrocyte precursor cell derivation, proliferation, and dispersion are explored and provide insight into white matter expansion and myelination in the human brain.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-16
  DOI: 10.1016/j.cell.2020.06.027
  Issue No: Vol. 182, No. 3 (2020)
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis
- Authors: Erika Sugisawa; Yasunori Takayama, Naoki Takemura, Takeshi Kondo, Shigetsugu Hatakeyama, Yutaro Kumagai, Masataka Sunagawa, Makoto Tominaga, Kenta Maruyama
  Pages: 609 - 624.e21
  Abstract: Maruyama et al. provide evidence from mouse experiments that fecal single-stranded RNA (ssRNA) is sensed in the gut by the cation channel Piezo1. They show that ssRNA-stimulated Piezo1 is involved in peristalsis and gut serotonin synthesis and reduced bone mass. The ssRNA-Piezo1 axis reported could be a prophylactic target for treatment of bone and gut disorders, including the side effects of certain serotonergic drugs.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-07
  DOI: 10.1016/j.cell.2020.06.022
  Issue No: Vol. 182, No. 3 (2020)
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult
Transition
- Authors: Emanuela Pasciuto; Oliver T. Burton, Carlos P. Roca, Vasiliki Lagou, Wenson D. Rajan, Tom Theys, Renzo Mancuso, Raul Y. Tito, Lubna Kouser, Zsuzsanna Callaerts-Vegh, Alerie G. de la Fuente, Teresa Prezzemolo, Loriana G. Mascali, Aleksandra Brajic, Carly E. Whyte, Lidia Yshii, Anna Martinez-Muriana, Michelle Naughton, Andrew Young, Alena Moudra, Pierre Lemaitre, Suresh Poovathingal, Jeroen Raes, Bart De Strooper, Denise C. Fitzgerald, James Dooley, Adrian Liston
  Pages: 625 - 640.e24
  Abstract: Identification of brain-resident CD4+ T cells in mice and humans, which are required for microglia maturation and proper synaptic pruning and behavior.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-22
  DOI: 10.1016/j.cell.2020.06.026
  Issue No: Vol. 182, No. 3 (2020)
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic
Redundancy
- Authors: Lin Wu; Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan-Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman, Rahul Satija, Dan R. Littman
  Pages: 641 - 654.e20
  Abstract: Metabolic redundancy differs according to microenvironments, making the glycolysis gene Gpi1 dispensable for homeostatic Th17 cells in normal tissue but essential for pathogenic Th17 cells in hypoxic inflamed tissue.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-01
  DOI: 10.1016/j.cell.2020.06.014
  Issue No: Vol. 182, No. 3 (2020)
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy
- Authors: Adrienne M. Luoma; Shengbao Suo, Hannah L. Williams, Tatyana Sharova, Keri Sullivan, Michael Manos, Peter Bowling, F. Stephen Hodi, Osama Rahma, Ryan J. Sullivan, Genevieve M. Boland, Jonathan A. Nowak, Stephanie K. Dougan, Michael Dougan, Guo-Cheng Yuan, Kai W. Wucherpfennig
  Pages: 655 - 671.e22
  Abstract: Single-cell analyses of immune checkpoint blockade-associated colitis patient samples reveal enrichment of regulatory T cells in colitic lesions and nominate inflammatory pathways for potential therapeutic intervention.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-29
  DOI: 10.1016/j.cell.2020.06.001
  Issue No: Vol. 182, No. 3 (2020)
Somatic Evolution in Non-neoplastic IBD-Affected Colon
- Authors: Sigurgeir Olafsson; Rebecca E. McIntyre, Tim Coorens, Timothy Butler, Hyunchul Jung, Philip S. Robinson, Henry Lee-Six, Mathijs A. Sanders, Kenneth Arestang, Claire Dawson, Monika Tripathi, Konstantina Strongili, Yvette Hooks, Michael R. Stratton, Miles Parkes, Inigo Martincorena, Tim Raine, Peter J. Campbell, Carl A. Anderson
  Pages: 672 - 684.e11
  Abstract: Whole-genome sequencing of inflammatory bowel disease patient samples allows insight into mutational burdens and processes associated with disease, including putative driver mutations positively selected in the diseased colon.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-21
  DOI: 10.1016/j.cell.2020.06.036
  Issue No: Vol. 182, No. 3 (2020)
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
- Authors: Mehdi Bouhaddou; Danish Memon, Bjoern Meyer, Kris M. White, Veronica V. Rezelj, Miguel Correa Marrero, Benjamin J. Polacco, James E. Melnyk, Svenja Ulferts, Robyn M. Kaake, Jyoti Batra, Alicia L. Richards, Erica Stevenson, David E. Gordon, Ajda Rojc, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Lisa Miorin, Elena Moreno, Cassandra Koh, Quang Dinh Tran, Alexandra Hardy, Rémy Robinot, Thomas Vallet, Benjamin E. Nilsson-Payant, Claudia Hernandez-Armenta, Alistair Dunham, Sebastian Weigang, Julian Knerr, Maya Modak, Diego Quintero, Yuan Zhou, Aurelien Dugourd, Alberto Valdeolivas, Trupti Patil, Qiongyu Li, Ruth Hüttenhain, Merve Cakir, Monita Muralidharan, Minkyu Kim, Gwendolyn Jang, Beril Tutuncuoglu, Joseph Hiatt, Jeffrey Z. Guo, Jiewei Xu, Sophia Bouhaddou, Christopher J.P. Mathy, Anna Gaulton, Emma J. Manners, Eloy Félix, Ying Shi, Marisa Goff, Jean K. Lim, Timothy McBride, Michael C. O’Neal, Yiming Cai, Jason C.J. Chang, David J. Broadhurst, Saker Klippsten, Emmie De wit, Andrew R. Leach, Tanja Kortemme, Brian Shoichet, Melanie Ott, Julio Saez-Rodriguez, Benjamin R. tenOever, R. Dyche Mullins, Elizabeth R. Fischer, Georg Kochs, Robert Grosse, Adolfo García-Sastre, Marco Vignuzzi, Jeffery R. Johnson, Kevan M. Shokat, Danielle L. Swaney, Pedro Beltrao, Nevan J. Krogan
  Pages: 685 - 712.e19
  Abstract: Phosphoproteomics analysis of SARS-CoV-2-infected Vero E6 cells reveals host cellular pathways hijacked by viral infection, leading to the identification of small molecules that target dysregulated pathways and elicit potent antiviral efficacy.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-28
  DOI: 10.1016/j.cell.2020.06.034
  Issue No: Vol. 182, No. 3 (2020)
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent
Protection against SARS-CoV-2
- Authors: Hui Wang; Yuntao Zhang, Baoying Huang, Wei Deng, Yaru Quan, Wenling Wang, Wenbo Xu, Yuxiu Zhao, Na Li, Jin Zhang, Hongyang Liang, Linlin Bao, Yanfeng Xu, Ling Ding, Weimin Zhou, Hong Gao, Jiangning Liu, Peihua Niu, Li Zhao, Wei Zhen, Hui Fu, Shouzhi Yu, Zhengli Zhang, Guangxue Xu, Changgui Li, Zhiyong Lou, Miao Xu, Chuan Qin, Guizhen Wu, George Fu Gao, Wenjie Tan, Xiaoming Yang
  Pages: 713 - 721.e9
  Abstract: Wang et al. report the development, characterization, and preclinical evaluation of an inactivated SARS-CoV-2 vaccine candidate for COVID-19 that safely induces high levels of neutralizing antibodies in multiple mammalian species and protective efficacy against SARS-CoV-2 challenge in rhesus macaques.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-06
  DOI: 10.1016/j.cell.2020.06.008
  Issue No: Vol. 182, No. 3 (2020)
A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and
SARS
- Authors: Lianpan Dai; Tianyi Zheng, Kun Xu, Yuxuan Han, Lili Xu, Enqi Huang, Yaling An, Yingjie Cheng, Shihua Li, Mei Liu, Mi Yang, Yan Li, Huijun Cheng, Yuan Yuan, Wei Zhang, Changwen Ke, Gary Wong, Jianxun Qi, Chuan Qin, Jinghua Yan, George F. Gao
  Pages: 722 - 733.e11
  Abstract: Gao et al. present the structure-guided design of a coronavirus immunogen comprised of two protein subunits each containing the virus spike receptor binding domain fused together via a disulfide link or tandem repeat. The immunogen elicits strong immunogenicity in mice and protects them against viral challenge. The vaccine design strategy can be universally applied to SARS, MERS, COVID-19, and other CoV vaccines to counter emerging threats.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-28
  DOI: 10.1016/j.cell.2020.06.035
  Issue No: Vol. 182, No. 3 (2020)
Generation of a Broadly Useful Model for COVID-19 Pathogenesis,
Vaccination, and Treatment
- Authors: Jing Sun; Zhen Zhuang, Jian Zheng, Kun Li, Roy Lok-Yin Wong, Donglan Liu, Jicheng Huang, Jiangping He, Airu Zhu, Jingxian Zhao, Xiaobo Li, Yin Xi, Rongchang Chen, Abeer N. Alshukairi, Zhao Chen, Zhaoyong Zhang, Chunke Chen, Xiaofang Huang, Fang Li, Xiaomin Lai, Dingbin Chen, Liyan Wen, Jianfen Zhuo, Yanjun Zhang, Yanqun Wang, Shuxiang Huang, Jun Dai, Yongxia Shi, Kui Zheng, Mariah R. Leidinger, Jiekai Chen, Yimin Li, Nanshan Zhong, David K. Meyerholz, Paul B. McCray, Stanley Perlman, Jincun Zhao
  Pages: 734 - 743.e5
  Abstract: An adenoviral transduction-based mouse model that can be infected with SARS-CoV-2 provides a tool to understand host factors involved in viral infection and clearance as well as potential therapeutic modalities.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-10
  DOI: 10.1016/j.cell.2020.06.010
  Issue No: Vol. 182, No. 3 (2020)
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by
Neutralizing Antibodies
- Authors: Ahmed O. Hassan; James Brett Case, Emma S. Winkler, Larissa B. Thackray, Natasha M. Kafai, Adam L. Bailey, Broc T. McCune, Julie M. Fox, Rita E. Chen, Wafaa B. Alsoussi, Jackson S. Turner, Aaron J. Schmitz, Tingting Lei, Swathi Shrihari, Shamus P. Keeler, Daved H. Fremont, Suellen Greco, Paul B. McCray, Stanley Perlman, Michael J. Holtzman, Ali H. Ellebedy, Michael S. Diamond
  Pages: 744 - 753.e4
  Abstract: Laboratory mice transduced with adenoviruses encoding human ACE2 are permissive for SARS-CoV-2 and develop pneumonia. Passive transfer of a neutralizing monoclonal antibody reduces lung infection, inflammation, and disease.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-10
  DOI: 10.1016/j.cell.2020.06.011
  Issue No: Vol. 182, No. 3 (2020)
A Chromatin Accessibility Atlas of the Developing Human Telencephalon
- Authors: Eirene Markenscoff-Papadimitriou; Sean Whalen, Pawel Przytycki, Reuben Thomas, Fadya Binyameen, Tomasz J. Nowakowski, Arnold R. Kriegstein, Stephan J. Sanders, Matthew W. State, Katherine S. Pollard, John L. Rubenstein
  Pages: 754 - 769.e18
  Abstract: A high-resolution atlas of regulatory elements driving regional, temporal, and laminar gene expression programs in the developing human telencephalon reveals enhancers and genetic variants regulating human disease genes.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-06-30
  DOI: 10.1016/j.cell.2020.06.002
  Issue No: Vol. 182, No. 3 (2020)
Revealing the Activity of Trimeric G-proteins in Live Cells with a
Versatile Biosensor Design
- Authors: Marcin Maziarz; Jong-Chan Park, Anthony Leyme, Arthur Marivin, Alberto Garcia-Lopez, Prachi P. Patel, Mikel Garcia-Marcos
  Pages: 770 - 785.e16
  Abstract: A suite of modular optical biosensors enables detection of G-protein activity in live cells in contexts ranging from tumor cells to primary neurons.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-07-06
  DOI: 10.1016/j.cell.2020.06.020
  Issue No: Vol. 182, No. 3 (2020)
SnapShot: Enveloped Virus Entry
- Authors: Jason Mercer; Jeffrey E. Lee, Erica Ollmann Saphire, Spencer A. Freeman
  Pages: 786 - 786.e1
  Abstract: In order to initiate successful infection, viruses have to transmit and deliver their genome from one host cell or organism to another. To achieve this, enveloped viruses must first fuse their membrane with those of the target host cell. Here, we describe the sequence of events leading to the entry of representative enveloped viruses, highlighting the strategies they use to gain access to the host cell cytosol.
  Citation: Cell 182, 3 (2020)
  PubDate: 2020-08-06
  DOI: 10.1016/j.cell.2020.06.033
  Issue No: Vol. 182, No. 3 (2020)