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Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1252  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [2974 journals]
  • Is aging a “Retro”spective event'

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      Authors: Nirmalya Dasgupta; Peter D. Adams
      Pages: 233 - 235
      Abstract: Reactivation of endogenous retroviruses (ERVs), the relics of ancient infections, has been implicated in a number of disease contexts. In this issue of Cell, Liu et al. show how reactivation of ERVs in old age can induce senescence. This awakening of ERVs is associated with epigenetic derepression and contributes to age-associated chronic inflammation.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-19
      DOI: 10.1016/j.cell.2022.12.040
      Issue No: Vol. 186, No. 2 (2023)
       
  • Coordinated cancer chaos

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      Authors: Hendrik A. Messal; Jacco van Rheenen
      Pages: 235 - 237
      Abstract: Stochastic processes, such as genetic instability and microenvironment evolution, drive tumor heterogeneity, thereby creating the chaotic appearance of tumors in histopathology. In this issue of Cell, Lin et al. reveal that tumors are surprisingly spatially organized from a molecular to tissue scale, indicating that cancers evolve as autonomously patterned systems.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-19
      DOI: 10.1016/j.cell.2022.12.015
      Issue No: Vol. 186, No. 2 (2023)
       
  • SON-light activation of glucose regulation

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      Authors: Gisela Geoghegan; Judith Simcox
      Pages: 238 - 240
      Abstract: Body temperature maintenance is an important regulator of glucose homeostasis. In this issue of Cell, Meng et al. discover a regulatory axis in which light activation of photoreceptive retinal ganglia stimulates the supraoptic nucleus (SON) to inhibit brown adipose tissue (BAT) thermogenesis and impair glucose homeostasis. This could explain the impact of constant light exposure on metabolism.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-19
      DOI: 10.1016/j.cell.2022.12.045
      Issue No: Vol. 186, No. 2 (2023)
       
  • From ABCD to E for endothelin in resistant hypertension

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      Authors: George R. Abraham; Anthony P. Davenport
      Pages: 240 - 242
      Abstract: The potent vasoconstrictor peptide endothelin-1 has long been recognized as a physiological regulator of vascular tone. However, pharmacological blockade of the endothelin-1 pathway has few proven indications thus far. A recent clinical trial for resistant hypertension published in The Lancet may yet herald a new era for endothelin receptor antagonists into the clinical mainstream.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-04
      DOI: 10.1016/j.cell.2022.12.014
      Issue No: Vol. 186, No. 2 (2023)
       
  • Hallmarks of aging: An expanding universe

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      Authors: Carlos López-Otín; Maria A. Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer
      Pages: 243 - 278
      Abstract: Aging is a complex and multifactorial process. This reprise of the 2013 “The hallmarks of aging” reviews conceptual progress, additional hallmarks of aging, their interconnection, and preclinical anti-aging manipulations.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-03
      DOI: 10.1016/j.cell.2022.11.001
      Issue No: Vol. 186, No. 2 (2023)
       
  • Resurrection of endogenous retroviruses during aging reinforces senescence

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      Authors: Xiaoqian Liu; Zunpeng Liu, Zeming Wu, Jie Ren, Yanling Fan, Liang Sun, Gang Cao, Yuyu Niu, Baohu Zhang, Qianzhao Ji, Xiaoyu Jiang, Cui Wang, Qiaoran Wang, Zhejun Ji, Lanzhu Li, Concepcion Rodriguez Esteban, Kaowen Yan, Wei Li, Yusheng Cai, Si Wang, Aihua Zheng, Yong E. Zhang, Shengjun Tan, Yingao Cai, Moshi Song, Falong Lu, Fuchou Tang, Weizhi Ji, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu
      Pages: 287 - 304.e26
      Abstract: Liu and colleagues uncover the ways in which derepression of human endogenous retrovirus triggers cellular senescence and tissue aging; the findings provide fresh insights into therapeutic strategies for alleviating aging.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-06
      DOI: 10.1016/j.cell.2022.12.017
      Issue No: Vol. 186, No. 2 (2023)
       
  • Loss of epigenetic information as a cause of mammalian aging

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      Authors: Jae-Hyun Yang; Motoshi Hayano, Patrick T. Griffin, João A. Amorim, Michael S. Bonkowski, John K. Apostolides, Elias L. Salfati, Marco Blanchette, Elizabeth M. Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M. Ross, Giuseppe Coppotelli, Margarita V. Meer, Ryan Rogers-Hammond, Daniel L. Vera, Yuancheng Ryan Lu, Jeffrey W. Pippin, Michael L. Creswell, Zhixun Dou, Caiyue Xu, Sarah J. Mitchell, Abhirup Das, Brendan L. O’Connell, Sachin Thakur, Alice E. Kane, Qiao Su, Yasuaki Mohri, Emi K. Nishimura, Laura Schaevitz, Neha Garg, Ana-Maria Balta, Meghan A. Rego, Meredith Gregory-Ksander, Tatjana C. Jakobs, Lei Zhong, Hiroko Wakimoto, Jihad El Andari, Dirk Grimm, Raul Mostoslavsky, Amy J. Wagers, Kazuo Tsubota, Stephen J. Bonasera, Carlos M. Palmeira, Jonathan G. Seidman, Christine E. Seidman, Norman S. Wolf, Jill A. Kreiling, John M. Sedivy, George F. Murphy, Richard E. Green, Benjamin A. Garcia, Shelley L. Berger, Philipp Oberdoerffer, Stuart J. Shankland, Vadim N. Gladyshev, Bruce R. Ksander, Andreas R. Pfenning, Luis A. Rajman, David A. Sinclair
      Pages: 305 - 326.e27
      Abstract: Aging is characterized by changes in cellular identity and function over time. This process is driven by changes in chromatin factor localization during DNA break repair, which alters the epigenome and advances the epigenetic clock. Expression of a subset of Yamanka factors, OSK, can reverse these changes and modulate aging.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-12
      DOI: 10.1016/j.cell.2022.12.027
      Issue No: Vol. 186, No. 2 (2023)
       
  • Functional partitioning of transcriptional regulators by patterned charge
           blocks

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      Authors: Heankel Lyons; Reshma T. Veettil, Prashant Pradhan, Christy Fornero, Nancy De La Cruz, Keiichi Ito, Mikayla Eppert, Robert G. Roeder, Benjamin R. Sabari
      Pages: 327 - 345.e28
      Abstract: Charge patterning in disordered regions of transcriptional regulators mediates selective partitioning into MED1IDR condensates for gene activation.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-04
      DOI: 10.1016/j.cell.2022.12.013
      Issue No: Vol. 186, No. 2 (2023)
       
  • An E3 ligase network engages GCN1 to promote the degradation of
           translation factors on stalled ribosomes

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      Authors: Keely Oltion; Jordan D. Carelli, Tangpo Yang, Stephanie K. See, Hao-Yuan Wang, Martin Kampmann, Jack Taunton
      Pages: 346 - 362.e17
      Abstract: Oltion et al. unveil a ubiquitin ligase network in charge of ensuring translation factor quality control in response to stalled ribosomes.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-12
      DOI: 10.1016/j.cell.2022.12.025
      Issue No: Vol. 186, No. 2 (2023)
       
  • Multiplexed 3D atlas of state transitions and immune interaction in
           colorectal cancer

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      Authors: Jia-Ren Lin; Shu Wang, Shannon Coy, Yu-An Chen, Clarence Yapp, Madison Tyler, Maulik K. Nariya, Cody N. Heiser, Ken S. Lau, Sandro Santagata, Peter K. Sorger
      Pages: 363 - 381.e19
      Abstract: Multiplexed whole-slide imaging analysis characterizes intermixed and graded morphological and molecular features in human colorectal cancer samples, highlighting large-scale cancer characteristic structural features and variations in intra-tertiary lymphoid cellular compositions and structural patterning.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-19
      DOI: 10.1016/j.cell.2022.12.028
      Issue No: Vol. 186, No. 2 (2023)
       
  • Lymphatic vessels in bone support regeneration after injury

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      Authors: Lincoln Biswas; Junyu Chen, Jessica De Angelis, Amit Singh, Charlotte Owen-Woods, Zhangfan Ding, Joan Mane Pujol, Naveen Kumar, Fanxin Zeng, Saravana K. Ramasamy, Anjali P. Kusumbe
      Pages: 382 - 397.e24
      Abstract: Lymphatic vessels not only connect secondary lymphoid organs with tissue sites throughout the body but are also now shown directly irrigating bones and participating in their regeneration.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-19
      DOI: 10.1016/j.cell.2022.12.031
      Issue No: Vol. 186, No. 2 (2023)
       
  • Light modulates glucose metabolism by a retina-hypothalamus-brown adipose
           tissue axis

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      Authors: Jian-Jun Meng; Jia-Wei Shen, Guang Li, Chang-Jie Ouyang, Jia-Xi Hu, Zi-Shuo Li, Hang Zhao, Yi-Ming Shi, Mei Zhang, Rong Liu, Ju-Tao Chen, Yu-Qian Ma, Huan Zhao, Tian Xue
      Pages: 398 - 412.e17
      Abstract: Identification of the neuro circuit connecting photoreception to adaptive thermogenesis in brown adipose tissue maps out the biological path mediating the effect of light on glucose metabolism, suggesting potential avenues for managing unintended consequences on metabolic homeostasis by light exposure.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-19
      DOI: 10.1016/j.cell.2022.12.024
      Issue No: Vol. 186, No. 2 (2023)
       
  • Structures of the entire human opioid receptor family

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      Authors: Yue Wang; Youwen Zhuang, Jeffrey F. DiBerto, X. Edward Zhou, Gavin P. Schmitz, Qingning Yuan, Manish K. Jain, Weiyi Liu, Karsten Melcher, Yi Jiang, Bryan L. Roth, H. Eric Xu
      Pages: 413 - 427.e17
      Abstract: Structures of all four human opioid receptors with the endogenous or exogenous opioid peptides are reported, which reveal the conserved mechanisms of opioid receptor activation and specific recognition of opioid peptides by the receptors.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-12
      DOI: 10.1016/j.cell.2022.12.026
      Issue No: Vol. 186, No. 2 (2023)
       
  • Dual-specificity RNA aptamers enable manipulation of target-specific
           O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin

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      Authors: Yi Zhu; Gerald W. Hart
      Pages: 428 - 445.e27
      Abstract: Zhu and Hart report the development of dual-specificity RNA aptamers for altering O-GlcNAcylation of specific proteins; this work provides a versatile tool kit for studying an elusive post-translational modification.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-09
      DOI: 10.1016/j.cell.2022.12.016
      Issue No: Vol. 186, No. 2 (2023)
       
  • An evolved AAV variant enables efficient genetic engineering of murine
           T cells

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      Authors: William A. Nyberg; Jonathan Ark, Angela To, Sylvanie Clouden, Gabriella Reeder, Joseph J. Muldoon, Jing-Yi Chung, William H. Xie, Vincent Allain, Zachary Steinhart, Christopher Chang, Alexis Talbot, Sandy Kim, Alan Rosales, L. Patrick Havlik, Harold Pimentel, Aravind Asokan, Justin Eyquem
      Pages: 446 - 460.e19
      Abstract: By combining structure-guided evolution and genome-wide screening, this work identifies an adeno-associated virus and co-factor that enable gene targeting at high efficiencies in mouse T lymphocytes, thus opening the path for T cell manipulations in murine models.
      Citation: Cell 186, 2 (2023)
      PubDate: 2023-01-12
      DOI: 10.1016/j.cell.2022.12.022
      Issue No: Vol. 186, No. 2 (2023)
       
  • Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB
           subvariants

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      Authors: Qian Wang; Sho Iketani, Zhiteng Li, Liyuan Liu, Yicheng Guo, Yiming Huang, Anthony D. Bowen, Michael Liu, Maple Wang, Jian Yu, Riccardo Valdez, Adam S. Lauring, Zizhang Sheng, Harris H. Wang, Aubree Gordon, Lihong Liu, David D. Ho
      Pages: 279 - 286.e8
      Abstract: Recent BQ and XBB subvariants of SARS-CoV-2 demonstrate dramatically increased ability to evade neutralizing antibodies, even those from people who received the bivalent mRNA booster or who are immunized and had previous breakthrough Omicron infection. Additionally, both BQ and XBB are completely resistant to bebtelovimab, meaning there are now no clinically authorized therapeutic antibodies effective against these circulating variants.
      Citation: Cell 186, 2 (2023)
      PubDate: 2022-12-13
      DOI: 10.1016/j.cell.2022.12.018
      Issue No: Vol. 186, No. 2 (2022)
       
 
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