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The Lancet
Journal Prestige (SJR): 14.934
Citation Impact (citeScore): 9
Number of Followers: 2353  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0140-6736 - ISSN (Online) 1474-547X
Published by Elsevier Homepage  [3163 journals]
  • Direct oral anticoagulants for postoperative myocardial injury
    • Authors: Tom Adriaenssens; Peter Sinnaeve
      Pages: 2297 - 2298
      Abstract: Publication date: 9–15 June 2018
      Source:The Lancet, Volume 391, Issue 10137
      Author(s): Tom Adriaenssens, Peter Sinnaeve


      PubDate: 2018-06-08T19:08:56Z
      DOI: 10.1016/s0140-6736(18)30988-7
       
  • Take a blood pressure pill or undergo renal denervation'
    • Authors: Sverre E Kjeldsen; Murray D Esler
      Pages: 2298 - 2300
      Abstract: Publication date: 9–15 June 2018
      Source:The Lancet, Volume 391, Issue 10137
      Author(s): Sverre E Kjeldsen, Murray D Esler


      PubDate: 2018-06-08T19:08:56Z
      DOI: 10.1016/s0140-6736(18)31126-7
       
  • Renal denervation in uncontrolled hypertension: the story continues to
           unfold
    • Authors: Peter J Blankestijn; Michiel L Bots
      Pages: 2300 - 2302
      Abstract: Publication date: 9–15 June 2018
      Source:The Lancet, Volume 391, Issue 10137
      Author(s): Peter J Blankestijn, Michiel L Bots


      PubDate: 2018-06-08T19:08:56Z
      DOI: 10.1016/s0140-6736(18)31112-7
       
  • Transparency and accountability in AstraZeneca's access to health-care
           programmes
    • Abstract: Publication date: Available online 18 June 2018
      Source:The Lancet
      Author(s): Katarina Ageborg


      PubDate: 2018-06-20T08:11:32Z
       
  • Mitochondrial medicine in the omics era
    • Abstract: Publication date: Available online 18 June 2018
      Source:The Lancet
      Author(s): Joyeeta Rahman, Shamima Rahman
      Mitochondria are dynamic bioenergetic organelles whose maintenance requires around 1500 proteins from two genomes. Mutations in either the mitochondrial or nuclear genome can disrupt a plethora of cellular metabolic and homoeostatic functions. Mitochondrial diseases represent one of the most common and severe groups of inherited genetic disorders, characterised by clinical, biochemical, and genetic heterogeneity, diagnostic odysseys, and absence of disease-modifying curative therapies. This Review aims to discuss recent advances in mitochondrial biology and medicine arising from widespread use of high-throughput omics technologies, and also includes a broad discussion of emerging therapies for mitochondrial disease. New insights into both bioenergetic and biosynthetic mitochondrial functionalities have expedited the genetic diagnosis of primary mitochondrial disorders, and identified novel mitochondrial pathomechanisms and new targets for therapeutic intervention. As we enter this new era of mitochondrial medicine, underpinned by global unbiased approaches and multifaceted investigation of mitochondrial function, omics technologies will continue to shed light on unresolved mitochondrial questions, paving the way for improved outcomes for patients with mitochondrial diseases.

      PubDate: 2018-06-20T08:11:32Z
       
  • Untangling the complications of diabetes
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): The Lancet


      PubDate: 2018-06-18T08:10:11Z
       
  • Living and dying with dementia
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): The Lancet


      PubDate: 2018-06-18T08:10:11Z
       
  • Long-term albumin in cirrhosis: is it the ANSWER'
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Guadalupe Garcia-Tsao


      PubDate: 2018-06-18T08:10:11Z
       
  • Diabetes mortality in the USA: winning the battle but not the war'
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Peter H Bennett


      PubDate: 2018-06-18T08:10:11Z
       
  • Screening men for AAA under magnification loupe in Sweden
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Stefan Acosta


      PubDate: 2018-06-18T08:10:11Z
       
  • Response to the Ebola virus disease outbreak in the Democratic Republic of
           the Congo
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): John N Nkengasong, Philip Onyebujoh


      PubDate: 2018-06-18T08:10:11Z
       
  • Troponin assays: developing indications
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Mark Mariathas, Nick Curzen


      PubDate: 2018-06-18T08:10:11Z
       
  • Sugar, tobacco, and alcohol taxes to achieve the SDGs
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Sugar Tobacco and Alcohol Taxes (STAX) GroupRobertMartenSowmyaKadandaleJohnButlerVictor MAguayoSvetlanaAxelrodNicholasBanatvalaDouglasBettcherLuisaBrumanaKentBuseSallyCasswellKatieDainAmandaGlassmanDavid LHeymannIlonaKickbuschPatricio VMarquezAndersNordströmJeremiasPaulJrStefanPetersonJohannaRalstonKumananRasanathanSrinathReddyRichard DSmithAgnèsSoucatKristinaSperkovaFrancisThompsonDouglasWebb


      PubDate: 2018-06-18T08:10:11Z
       
  • Offline: NCDs, WHO, and the neoliberal utopia
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Richard Horton


      PubDate: 2018-06-18T08:10:11Z
       
  • From Ireland to Northern Ireland: campaigns for abortion law
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Angel Li


      PubDate: 2018-06-18T08:10:11Z
       
  • When genomics goes digital
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Evan D Muse, Ali Torkamani, Eric J Topol


      PubDate: 2018-06-18T08:10:11Z
       
  • Teeth and inequality: from past to present
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Richard G Watt


      PubDate: 2018-06-18T08:10:11Z
       
  • Chen Wang: new President of CAMS and PUMC
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Geoff Watts


      PubDate: 2018-06-18T08:10:11Z
       
  • Insomnia: a cultural history
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Kimberley Whitehead, Matthew Beaumont


      PubDate: 2018-06-18T08:10:11Z
       
  • The hospital reunion
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Marco De Ambrogi


      PubDate: 2018-06-18T08:10:11Z
       
  • Donald W Seldin
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Ivan Oransky, Adam Marcus


      PubDate: 2018-06-18T08:10:11Z
       
  • A herbal treatment for type 2 diabetes adulterated with undisclosed drugs
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Mia Steyn, Lewis Couchman, Gemma Coombes, Kenneth A Earle, Atholl Johnston, David W Holt


      PubDate: 2018-06-18T08:10:11Z
       
  • Endpoints in diabetes cardiovascular outcome trials
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Tejas Patel, Bereket Tesfaldet, Iffat Chowdhury, Anna Kettermann, James P Smith, Frank Pucino, Eileen E Navarro Almario


      PubDate: 2018-06-18T08:10:11Z
       
  • Cross-border collaboration and an advanced gastrointestinal endoscopic
           unit in Gaza
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Iyad Khamaysi, Khaled Matar


      PubDate: 2018-06-18T08:10:11Z
       
  • How gaps in policy implementation cause public health malpractice
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Joyce R Javier, Heather L Brumberg, Lee Sanders, Tamara S Hannon, Shetal Shah


      PubDate: 2018-06-18T08:10:11Z
       
  • Lancet Commission on pollution: action plans and human resource
           development in India
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): S Gangamma


      PubDate: 2018-06-18T08:10:11Z
       
  • Accelerating the evidence for new classes of long-lasting
           insecticide-treated nets
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Natacha Protopopoff, Mark Rowland


      PubDate: 2018-06-18T08:10:11Z
       
  • Department of Error
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138


      PubDate: 2018-06-18T08:10:11Z
       
  • Department of Error
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138


      PubDate: 2018-06-18T08:10:11Z
       
  • Concentric circles in left atrium
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Xiaojun Xie, Jiao Bai


      PubDate: 2018-06-18T08:10:11Z
       
  • Type 1 diabetes
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Linda A DiMeglio, Carmella Evans-Molina, Richard A Oram
      Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

      PubDate: 2018-06-18T08:10:11Z
       
  • Genomic insights into the causes of type 2 diabetes
    • Abstract: Publication date: 16–22 June 2018
      Source:The Lancet, Volume 391, Issue 10138
      Author(s): Claudia Langenberg, Luca A Lotta
      Genome-wide association studies have implicated around 250 genomic regions in predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for several of these regions. Understanding of the underlying mechanisms, including the interplay between β-cell failure, insulin sensitivity, appetite regulation, and adipose storage has been facilitated by the integration of multidimensional data for diabetes-related intermediate phenotypes, detailed genomic annotations, functional experiments, and now multiomic molecular features. Studies in diverse ethnic groups and examples from population isolates have shown the value and need for a broad genomic approach to this global disease. Transethnic discovery efforts and large-scale biobanks in diverse populations and ancestries could help to address some of the Eurocentric bias. Despite rapid progress in the discovery of the highly polygenic architecture of type 2 diabetes, dominated by common alleles with small, cumulative effects on disease risk, these insights have been of little clinical use in terms of disease prediction or prevention, and have made only small contributions to subtype classification or stratified approaches to treatment. Successful development of academia–industry partnerships for exome or genome sequencing in large biobanks could help to deliver economies of scale, with implications for the future of genomics-focused research.

      PubDate: 2018-06-18T08:10:11Z
       
  • Idiopathic nephrotic syndrome in children
    • Abstract: Publication date: Available online 14 June 2018
      Source:The Lancet
      Author(s): Damien G Noone, Kazumoto Iijima, Rulan Parekh
      The incidence of idiopathic nephrotic syndrome (NS) is 1·15–16·9 per 100 000 children, varying by ethnicity and region. The cause remains unknown but the pathogenesis of idiopathic NS is thought to involve immune dysregulation, systemic circulating factors, or inherited structural abnormalities of the podocyte. Genetic risk is more commonly described among children with steroid-resistant disease. The mainstay of therapy is prednisone for the vast majority of patients who are steroid responsive; however, the disease can run a frequently relapsing course, necessitating the need for alternative immunosuppressive agents. Infection and venous thromboembolism are the main complications of NS with also increased risk of acute kidney injury. Prognosis in terms of long-term kidney outcome overall is excellent for steroid-responsive disease, and steroid resistance is an important determinant of future risk of chronic or end-stage kidney disease.

      PubDate: 2018-06-18T08:10:11Z
       
  • Immunological investigations empower transplant drug trials
    • Abstract: Publication date: Available online 14 June 2018
      Source:The Lancet
      Author(s): Edward K Geissler, James A Hutchinson


      PubDate: 2018-06-18T08:10:11Z
       
  • Sodium bicarbonate for severe metabolic acidaemia
    • Abstract: Publication date: Available online 14 June 2018
      Source:The Lancet
      Author(s): Jeffrey A Kraut, Nicolaos E Madias


      PubDate: 2018-06-18T08:10:11Z
       
  • New-generation JAK inhibitors: how selective can they be'
    • Abstract: Publication date: Available online 13 June 2018
      Source:The Lancet
      Author(s): Guro L Goll, Tore K Kvien


      PubDate: 2018-06-18T08:10:11Z
       
  • France may be back, but the old ways persist for INSERM
    • Abstract: Publication date: Available online 12 June 2018
      Source:The Lancet
      Author(s): The Lancet


      PubDate: 2018-06-12T19:12:13Z
       
  • Department of Error
    • Abstract: Publication date: Available online 11 June 2018
      Source:The Lancet


      PubDate: 2018-06-12T19:12:13Z
       
  • Department of Error
    • Abstract: Publication date: Available online 11 June 2018
      Source:The Lancet


      PubDate: 2018-06-12T19:12:13Z
       
  • Argentina votes on bill to legalise abortion up to 14 weeks
    • Abstract: Publication date: Available online 11 June 2018
      Source:The Lancet
      Author(s): Amy Booth


      PubDate: 2018-06-11T19:12:11Z
       
  • Nipah virus control needs more than R&D
    • Authors: Lancet
      Abstract: Publication date: 9–15 June 2018
      Source:The Lancet, Volume 391, Issue 10137
      Author(s): The Lancet


      PubDate: 2018-06-08T19:08:56Z
       
  • Dolutegravir for HIV: a lesson in pregnancy safety research
    • Authors: Lancet
      Abstract: Publication date: 9–15 June 2018
      Source:The Lancet, Volume 391, Issue 10137
      Author(s): The Lancet


      PubDate: 2018-06-08T19:08:56Z
       
  • False hope with the Right to Try Act
    • Authors: Lancet
      Abstract: Publication date: 9–15 June 2018
      Source:The Lancet, Volume 391, Issue 10137
      Author(s): The Lancet


      PubDate: 2018-06-08T19:08:56Z
       
 
 
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