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British Journal of Psychiatry
Journal Prestige (SJR): 2.844
Citation Impact (citeScore): 3
Number of Followers: 191  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0007-1250 - ISSN (Online) 1472-1465
Published by Cambridge University Press Homepage  [372 journals]
  • BJP volume 213 issue 3 Cover and Front matter
    • PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.171
      Issue No: Vol. 213, No. 3 (2018)
  • BJP volume 213 issue 3 Cover and Back matter
    • PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.172
      Issue No: Vol. 213, No. 3 (2018)
  • Rise of the machines' Machine learning approaches and mental health:
           opportunities and challenges
    • Authors: Paul A. Tiffin; Lewis W. Paton
      Pages: 509 - 510
      Abstract: Machine learning methods are being increasingly applied to physical healthcare. In this article we describe some of the potential benefits, challenges and limitations of this approach in a mental health context. We provide a number of examples where machine learning could add value beyond conventional statistical modelling.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.105
      Issue No: Vol. 213, No. 3 (2018)
  • Security of mind: 20 years of attachment theory and its relevance to
    • Authors: Gwen Adshead
      Pages: 511 - 513
      Abstract: In this editorial, I suggest that no psychiatrist should be without a working knowledge of attachment theory, and it is a capability that all trainees should cover in the proposed new curriculum. I have focused on three domains of research to argue that attachment theory is relevant to practicing psychiatrists.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.104
      Issue No: Vol. 213, No. 3 (2018)
  • Neurotrophins, cytokines, oxidative stress mediators and mood state in
           bipolar disorder: systematic review and meta-analyses
    • Authors: Tobias Rowland; Benjamin I. Perry, Rachel Upthegrove, Nicholas Barnes, Jayanta Chatterjee, Daniel Gallacher, Steven Marwaha
      Pages: 514 - 525
      Abstract: BackgroundA reliable biomarker signature for bipolar disorder sensitive to illness phase would be of considerable clinical benefit. Among circulating blood-derived markers there has been a significant amount of research into inflammatory markers, neurotrophins and oxidative stress markers.AimsTo synthesise and interpret existing evidence of inflammatory markers, neurotrophins and oxidative stress markers in bipolar disorder focusing on the mood phase of illness.MethodFollowing PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, a systematic review was conducted for studies investigating peripheral biomarkers in bipolar disorder compared with healthy controls. We searched Medline, Embase, PsycINFO, SciELO and Web of Science, and separated studies by bipolar mood phase (mania, depression and euthymia). Extracted data on each biomarker in separate mood phases were synthesised using random-effects model meta-analyses.ResultsIn total, 53 studies were included, comprising 2467 cases and 2360 controls. Fourteen biomarkers were identified from meta-analyses of three or more studies. No biomarker differentiated mood phase in bipolar disorder individually. Biomarker meta-analyses suggest a combination of high-sensitivity C-reactive protein/interleukin-6, brain derived neurotrophic factor/tumour necrosis factor (TNF)-α and soluble TNF-α receptor 1 can differentiate specific mood phase in bipolar disorder. Several other biomarkers of interest were identified.ConclusionsCombining biomarker results could differentiate individuals with bipolar disorder from healthy controls and indicate a specific mood-phase signature. Future research should seek to test these combinations of biomarkers in longitudinal studies.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.144
      Issue No: Vol. 213, No. 3 (2018)
  • Young adult mental health and functional outcomes among individuals with
           remitted, persistent and late-onset ADHD
    • Authors: Jessica C. Agnew-Blais; Guilherme V. Polanczyk, Andrea Danese, Jasmin Wertz, Terrie E. Moffitt, Louise Arseneault
      Pages: 526 - 534
      Abstract: BackgroundAttention-deficit hyperactivity disorder (ADHD) is associated with mental health problems and functional impairment across many domains. However, how the longitudinal course of ADHD affects later functioning remains unclear.AimsWe aimed to disentangle how ADHD developmental patterns are associated with young adult functioning.MethodThe Environmental Risk (E-Risk) Longitudinal Twin Study is a population-based cohort of 2232 twins born in England and Wales in 1994–1995. We assessed ADHD in childhood at ages 5, 7, 10 and 12 years and in young adulthood at age 18 years. We examined three developmental patterns of ADHD from childhood to young adulthood – remitted, persistent and late-onset ADHD – and compared these groups with one another and with non-ADHD controls on functioning at age 18 years. We additionally tested whether group differences were attributable to childhood IQ, childhood conduct disorder or familial factors shared between twins.ResultsCompared with individuals without ADHD, those with remitted ADHD showed poorer physical health and socioeconomic outcomes in young adulthood. Individuals with persistent or late-onset ADHD showed poorer functioning across all domains, including mental health, substance misuse, psychosocial, physical health and socioeconomic outcomes. Overall, these associations were not explained by childhood IQ, childhood conduct disorder or shared familial factors.ConclusionsLong-term associations of childhood ADHD with adverse physical health and socioeconomic outcomes underscore the need for early intervention. Young adult ADHD showed stronger associations with poorer mental health, substance misuse and psychosocial outcomes, emphasising the importance of identifying and treating adults with ADHD.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.97
      Issue No: Vol. 213, No. 3 (2018)
  • On Worry – psychiatry in literature
    • Authors: Aruna Rose Mary Kapanee
      Pages: 534 - 534
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.114
      Issue No: Vol. 213, No. 3 (2018)
  • Use of schizophrenia and bipolar disorder polygenic risk scores to
           identify psychotic disorders
    • Authors: Maria Stella Calafato; Johan H. Thygesen, Siri Ranlund, Eirini Zartaloudi, Wiepke Cahn, Benedicto Crespo-Facorro, Álvaro Díez-Revuelta, Marta Di Forti, Mei-Hua Hall, Conrad Iyegbe, Assen Jablensky, Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Kuang Lin, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Marco Picchioni, Dan Rujescu, Madiha Shaikh, Timothea Toulopoulou, Jim Van Os, Evangelos Vassos, Muriel Walshe, John Powell, Cathryn M. Lewis, Robin M. Murray, Elvira Bramon
      Pages: 535 - 541
      Abstract: BackgroundThere is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls.MethodUsing the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.ResultsPatients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polygenic risk scores, as did their relatives, albeit to a lesser degree. However, the accuracy of predictive models was modest.ConclusionsAlthough polygenic risk scores are not ready for clinical use, it is hoped that as they are refined they could help towards risk reduction advice and early interventions for psychosis.Declaration of interestR.M.M. has received honoraria for lectures from Janssen, Lundbeck, Lilly, Otsuka and Sunovian.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.89
      Issue No: Vol. 213, No. 3 (2018)
  • Stratification of the risk of bipolar disorder recurrences in pregnancy
           and postpartum
    • Authors: Arianna Di Florio; Katherine Gordon-Smith, Liz Forty, Michael R. Kosorok, Christine Fraser, Amy Perry, Andrew Bethell, Nick Craddock, Lisa Jones, Ian Jones
      Pages: 542 - 547
      Abstract: BackgroundPregnancy and childbirth are a period of high risk for women with bipolar disorder and involve difficult decisions particularly about continuing or stopping medications.AimsTo explore what clinical predictors may help to individualise the risk of perinatal recurrence in women with bipolar disorder.MethodInformation was gathered retrospectively by semi-structured interview, questionnaires and case-note review from 887 women with bipolar disorder who have had children. Clinical predictors were selected using backwards stepwise logistic regression, conditional permutation random forests and reinforcement learning trees.ResultsPrevious perinatal history of affective psychosis or depression was the most significant predictor of a perinatal recurrence (odds ratio (OR) = 8.5, 95% CI 5.04–14.82 and OR = 3.6, 95% CI 2.55–5.07 respectively) but even parous women with bipolar disorder without a previous perinatal mood episode were at risk following a subsequent pregnancy, with 7% developing postpartum psychosis.ConclusionsPrevious perinatal history of affective psychosis or depression is the most important predictor of perinatal recurrence in women with bipolar disorder and can be used to individualise risk assessments.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.92
      Issue No: Vol. 213, No. 3 (2018)
  • Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar
           disorder type I, type II, unaffected siblings and healthy controls
    • Authors: Sonya F. Foley; Matthew Bracher-Smith, Katherine E. Tansey, Judith R. Harrison, Greg D. Parker, Xavier Caseras
      Pages: 548 - 554
      Abstract: BackgroundFractional anisotropy in the uncinate fasciculus and the cingulum may be biomarkers for bipolar disorder and may even be distinctly affected in different subtypes of bipolar disorder, an area in need of further research.AimsThis study aims to establish if fractional anisotropy in the uncinate fasciculus and cingulum shows differences between healthy controls, patients with bipolar disorder type I (BD-I) and type II (BD-II), and their unaffected siblings.MethodFractional anisotropy measures from the uncinate fasciculus, cingulum body and parahippocampal cingulum were compared with tractography methods in 40 healthy controls, 32 patients with BD-I, 34 patients with BD-II, 17 siblings of patients with BD-I and 14 siblings of patients with BD-II.ResultsThe main effects were found in both the right and left uncinate fasciculus, with patients with BD-I showing significantly lower fractional anisotropy than both patients with BD-II and healthy controls. Participants with BD-II did not differ from healthy controls. Siblings showed similar effects in the left uncinate fasciculus. In a subsequent complementary analysis, we investigated the association between fractional anisotropy in the uncinate fasciculus and polygenic risk for bipolar disorder and psychosis in a large cohort (n = 570) of healthy participants. However, we found no significant association.ConclusionsFractional anisotropy in the uncinate fasciculus differs significantly between patients with BD-I and patients with BD-II and healthy controls. This supports the hypothesis of differences in the physiological sub-tract between bipolar disorder subtypes. Similar results were found in unaffected siblings, suggesting the potential for this biomarker to represent an endophenotype for BD-I. However, fractional anisotropy in the uncinate fasciculus seems unrelated to polygenic risk for bipolar disorder or psychosis.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.101
      Issue No: Vol. 213, No. 3 (2018)
  • Attention-deficit hyperactivity disorder and anxiety disorders as
           precursors of bipolar disorder onset in adulthood
    • Authors: Sandra M. Meier; Barbara Pavlova, Søren Dalsgaard, Merete Nordentoft, Ole Mors, Preben B. Mortensen, Rudolf Uher
      Pages: 555 - 560
      Abstract: BackgroundAttention-deficit hyperactivity disorder (ADHD) and anxiety disorders have been proposed as precursors of bipolar disorder, but their joint and relative roles in the development of bipolar disorder are unknown.AimsTo test the prospective relationship of ADHD and anxiety with onset of bipolar disorder.MethodWe examined the relationship between ADHD, anxiety disorders and bipolar disorder in a birth cohort of 2 409 236 individuals born in Denmark between 1955 and 1991. Individuals were followed from their sixteenth birthday or from January 1995 to their first clinical contact for bipolar disorder or until December 2012. We calculated incidence rates per 10 000 person-years and tested the effects of prior diagnoses on the risk of bipolar disorder in survival models.ResultsOver 37 394 865 person-years follow-up, 9250 onsets of bipolar disorder occurred. The incidence rate of bipolar disorder was 2.17 (95% CI 2.12–2.19) in individuals with no prior diagnosis of ADHD or anxiety, 23.86 (95% CI 19.98–27.75) in individuals with a prior diagnosis of ADHD only, 26.05 (95% CI 24.47–27.62) in individuals with a prior diagnosis of anxiety only and 66.16 (95% CI 44.83–87.47) in those with prior diagnoses of both ADHD and anxiety. The combination of ADHD and anxiety increased the risk of bipolar disorder 30-fold (95% CI 21.66–41.40) compared with those with no prior ADHD or anxiety.ConclusionsEarly manifestations of both internalising and externalising psychopathology indicate liability to bipolar disorder. The combination of ADHD and anxiety is associated with a very high risk of bipolar disorder.Declaration of interestNone.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.111
      Issue No: Vol. 213, No. 3 (2018)
  • Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia
           spectrum disorders – CORRIGENDUM
    • Authors: Tatiana Oviedo-Salcedo; Lot de Witte, Tania Kümpfel, René S. Kahn, Peter Falkai, Peter Eichhorn, Jurjen Luykx, Alkomiet Hasan
      Pages: 561 - 561
      Abstract: This notice describes a correction to the above mentioned paper.
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.77
      Issue No: Vol. 213, No. 3 (2018)
  • The+Female+Mind:+A+User's+Guide+By+Professor+Kathryn+Abel+and+Dr+Rosalind+Ramsay.+RCPsych+Publications2017.+£13.99+(pb).+128+pp.+ISBN+9781909726802&rft.title=British+Journal+of+Psychiatry&rft.issn=0007-1250&">The Female Mind: A User's Guide By Professor Kathryn Abel and Dr Rosalind
           Ramsay. RCPsych Publications2017. £13.99 (pb). 128 pp. ISBN 9781909726802
    • Authors: Dean Connolly
      Pages: 562 - 562
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.37
      Issue No: Vol. 213, No. 3 (2018)
  • Colours+of+Ageing:+30+years+of+Research+on+the+Mental+Health+of+the+Singapore+Elderly+By+Kua+Ee+Heok.+Write+Editions.+2017.+US+$24.99+(hb).+180+pp.+ISBN+978-981-11-1946-0&rft.title=British+Journal+of+Psychiatry&rft.issn=0007-1250&">Colours of Ageing: 30 years of Research on the Mental Health of the
           Singapore Elderly By Kua Ee Heok. Write Editions. 2017. US $24.99 (hb).
           180 pp. ISBN 978-981-11-1946-0
    • Authors: Jeremy Holmes
      Pages: 562 - 563
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.51
      Issue No: Vol. 213, No. 3 (2018)
  • Global+Perspectives+on+ADHD:+Social+Dimensions+of+Diagnosis+and+Treatment+in+Sixteen+Countries+Edited+by+Meredith+R.+Bergey,+Angela+M.+Filipe,+Peter+Conrad+and+Ilina+Singh.+Johns+Hopkins+University+Press.+2017.+£48.00+(pb).+416+pp.+ISBN+9781421423791&rft.title=British+Journal+of+Psychiatry&rft.issn=0007-1250&">Global Perspectives on ADHD: Social Dimensions of Diagnosis and Treatment
           in Sixteen Countries Edited by Meredith R. Bergey, Angela M. Filipe, Peter
           Conrad and Ilina Singh. Johns Hopkins University Press. 2017. £48.00
           (pb). 416 pp. ISBN 9781421423791
    • Authors: Sami Timimi
      Pages: 563 - 563
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.108
      Issue No: Vol. 213, No. 3 (2018)
  • Thinking+Fast+and+Slow+By+Daniel+Kahneman.+Penguin.+2012.+£10.99+(pb).+512+pp.+ISBN+9780141033570.&rft.title=British+Journal+of+Psychiatry&rft.issn=0007-1250&">Thinking Fast and Slow By Daniel Kahneman. Penguin. 2012. £10.99 (pb).
           512 pp. ISBN 9780141033570.
    • Authors: Eugene G. Breen
      Pages: 563 - 564
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.109
      Issue No: Vol. 213, No. 3 (2018)
  • Off+the+Deep+End.+A+History+of+Madness+at+Sea+By+Nic+Compton+Adlard+Coles+Nautical,+Bloomsbury.+2017.+£16.99+(hb).+288+pp.+ISBN+9781472941121&rft.title=British+Journal+of+Psychiatry&rft.issn=0007-1250&">Off the Deep End. A History of Madness at Sea By Nic Compton Adlard Coles
           Nautical, Bloomsbury. 2017. £16.99 (hb). 288 pp. ISBN 9781472941121
    • Authors: Martin Deahl
      Pages: 565 - 565
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.112
      Issue No: Vol. 213, No. 3 (2018)
  • Psychoanalysis,+The+NHS,+and+Mental+Health+Work+Today.+Psychoanalytic+Ideas+Edited+by+Alison+Vaspe.+Karnac+Books.+2017.+£31.99+(pb).+320+pp.+ISBN+9781782203681&rft.title=British+Journal+of+Psychiatry&rft.issn=0007-1250&">Psychoanalysis, The NHS, and Mental Health Work Today. Psychoanalytic
           Ideas Edited by Alison Vaspe. Karnac Books. 2017. £31.99 (pb). 320 pp.
           ISBN 9781782203681
    • Authors: William Burbridge-James
      Pages: 565 - 566
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.120
      Issue No: Vol. 213, No. 3 (2018)
  • Kaleidoscope
    • Authors: Derek K. Tracy; Dan W. Joyce, Sukhwinder S. Shergill
      Pages: 568 - 569
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.163
      Issue No: Vol. 213, No. 3 (2018)
  • Impulsivity, Attachment, and Relational Psychopathology
    • Authors: By Kamaldeep Bhui
      Pages: 570 - 570
      PubDate: 2018-09-01T00:00:00.000Z
      DOI: 10.1192/bjp.2018.170
      Issue No: Vol. 213, No. 3 (2018)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
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