Followed Journals
Journal you Follow: 0
 
Sign Up to follow journals, search in your chosen journals and, optionally, receive Email Alerts when new issues of your Followed Journals are published.
Already have an account? Sign In to see the journals you follow.
Similar Journals
Journal Cover
Proceedings of the National Academy of Sciences
Journal Prestige (SJR): 6.092
Citation Impact (citeScore): 9
Number of Followers: 1366  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0027-8424 - ISSN (Online) 1091-6490
Published by PNAS Homepage  [1 journal]
  • An ultra-low-cost electroporator with microneedle electrodes (ePatch) for
           SARS-CoV-2 vaccination [Engineering]

    • Free pre-print version: Loading...

      Authors: Dengning Xia; Rui Jin, Gaurav Byagathvalli, Huan Yu, Ling Ye, Chao-Yi Lu, M. Saad Bhamla, Chinglai Yang, Mark R. Prausnitz
      Abstract: Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other pathogens with pandemic potential requires safe, protective, inexpensive, and easily accessible vaccines that can be developed and manufactured rapidly at a large scale. DNA vaccines can achieve these criteria, but induction of strong immune responses has often required bulky,...
      Keywords: Engineering, Immunology and Inflammation, Coronavirus (COVID-19)
      PubDate: 2021-10-20T11:27:24-07:00
      DOI: 10.1073/pnas.2110817118
      Issue No: Vol. 118, No. 45 (2021)
       
  • Pterosaurs evolved a muscular wing-body ȷunction providing multifaceted
           flight performance benefits: Advanced aerodynamic smoothing, sophisticated
           wing root control, and wing force generation [Evolution]

    • Free pre-print version: Loading...

      Authors: Michael Pittman; Luke A. Barlow, Thomas G. Kaye, Michael B. Habib
      Abstract: Pterosaurs were the first vertebrate flyers and lived for over 160 million years. However, aspects of their flight anatomy and flight performance remain unclear. Using laser-stimulated fluorescence, we observed direct soft tissue evidence of a wing root fairing in a pterosaur, a feature that smooths out the wing–body junction, reducing...
      Keywords: Evolution, Brief Reports
      PubDate: 2021-10-18T12:06:17-07:00
      DOI: 10.1073/pnas.2107631118
      Issue No: Vol. 118, No. 44 (2021)
       
  • A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and
           its variants [Immunology and Inflammation]

    • Free pre-print version: Loading...

      Authors: Novalia Pishesha; Thibault J. Harmand, Paul W. Rothlauf, Patrique Praest, Ryan K. Alexander, Renate van den Doel, Mariel J. Liebeskind, Maria A. Vakaki, Nicholas McCaul, Charlotte Wijne, Elisha Verhaar, William Pinney III, Hailey Heston, Louis-Marie Bloyet, Marjorie Cornejo Pontelli, Ma. Xenia G. Ilagan, Robert Jan Lebbink, William J. Buchser, Emmanuel J. H. J. Wiertz, Sean P. J. Whelan, Hidde L. Ploegh
      Abstract: The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 100 million infections and millions of deaths. Effective vaccines remain the best hope of curtailing SARS-CoV-2 transmission, morbidity, and mortality. The vaccines in current use require cold storage and sophisticated manufacturing capacity, which complicates their...
      Keywords: Immunology and Inflammation, Coronavirus (COVID-19)
      PubDate: 2021-10-15T12:00:55-07:00
      DOI: 10.1073/pnas.2116147118
      Issue No: Vol. 118, No. 44 (2021)
       
  • Differential effects of PD-1 and CTLA-4 blockade on the melanoma-reactive
           CD8 T cell response [Immunology and Inflammation]

    • Free pre-print version: Loading...

      Authors: Anastasia Gangaev; Elisa A. Rozeman, Maartje W. Rohaan, Olga I. Isaeva, Daisy Philips, Sanne Patiwael, Joost H. van den Berg, Antoni Ribas, Dirk Schadendorf, Bastian Schilling, Ton N. Schumacher, Christian U. Blank, John B. A. G. Haanen, Pia Kvistborg
      Abstract: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) have revolutionized the treatment of melanoma patients. Based on early studies addressing the mechanism of action, it was assumed that PD-1 blockade mostly influences T cell responses at the tumor site. However, recent...
      Keywords: Immunology and Inflammation
      PubDate: 2021-10-20T11:25:45-07:00
      DOI: 10.1073/pnas.2102849118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Eccentricity forcing of East Asian monsoonal systems over the past 3
           million years [Earth, Atmospheric, and Planetary Sciences]

    • Free pre-print version: Loading...

      Authors: Chengying Liu; Junsheng Nie, Zaijun Li, Qingqing Qiao, Jordan T. Abell, Fei Wang, Wenjiao Xiao
      Abstract: The East Asian summer monsoon and the precipitation it brings are relevant for millions of people. Because of the monsoon’s importance, there has been a substantial amount of work attempting to describe the driving mechanisms behind its past variability. However, discrepancies exist, with speleothem-based East Asian monsoon reconstructions differing from...
      Keywords: Earth, Atmospheric, and Planetary Sciences
      PubDate: 2021-10-20T11:25:45-07:00
      DOI: 10.1073/pnas.2107055118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus
           controls locomotion in a mouse model of Parkinson’s disease
           [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Maxime Fougere; Cornelis Immanuel van der Zouwen, Joel Boutin, Kloe Neszvecsko, Philippe Sarret, Dimitri Ryczko
      Abstract: In Parkinson’s disease (PD), the loss of midbrain dopaminergic cells results in severe locomotor deficits, such as gait freezing and akinesia. Growing evidence indicates that these deficits can be attributed to the decreased activity in the mesencephalic locomotor region (MLR), a brainstem region controlling locomotion. Clinicians are exploring the deep...
      Keywords: Neuroscience
      PubDate: 2021-10-20T11:25:45-07:00
      DOI: 10.1073/pnas.2110934118
      Issue No: Vol. 118, No. 43 (2021)
       
  • The translatome of neuronal cell bodies, dendrites, and axons
           [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Caspar Glock; Anne Biever, Georgi Tushev, Belquis Nassim-Assir, Allison Kao, Ina Bartnik, Susanne tom Dieck, Erin M. Schuman
      Abstract: To form synaptic connections and store information, neurons continuously remodel their proteomes. The impressive length of dendrites and axons imposes logistical challenges to maintain synaptic proteins at locations remote from the transcription source (the nucleus). The discovery of thousands of messenger RNAs (mRNAs) near synapses suggested that neurons overcome distance...
      Keywords: Neuroscience
      PubDate: 2021-10-20T11:25:45-07:00
      DOI: 10.1073/pnas.2113929118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Opinion: The importance of offering vaccine choice in the fight against
           COVID-19 [Social Sciences]

    • Free pre-print version: Loading...

      Authors: Mark T. Hughes; Paul G. Auwaerter, Michael R. Ehmann, Brian T. Garibaldi, Sherita H. Golden, Ting–Jia Lorigiano, Katie J. O’Conor, Allen Kachalia, Jeffrey Kahn
      Abstract: More than 25% of adults in the United States remain unvaccinated for coronavirus disease 2019 [COVID-19 (1)]. Although some of the unvaccinated are vaccine-resistant and may never be convinced that they should get the shot, the hope is that a sizable proportion of the unvaccinated will accept vaccination under the...
      Keywords: Opinions, Medical Sciences, Social Sciences, Front Matter, Coronavirus Related
      PubDate: 2021-10-20T11:25:45-07:00
      DOI: 10.1073/pnas.2117185118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Short-term high-fat feeding exacerbates degeneration in retinitis
           pigmentosa by promoting retinal oxidative stress and inflammation
           [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Oksana Kutsyr; Agustina Noailles, Natalia Martinez–Gil, Lucia Maestre–Carballa, Manuel Martinez–Garcia, Victoria Maneu, Nicolas Cuenca, Pedro Lax
      Abstract: A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal degeneration, we assessed retinal function and morphology, inflammatory state, oxidative stress, and gut microbiome in dystrophic retinal degeneration 10 (rd10) mice, a model...
      Keywords: Neuroscience
      PubDate: 2021-10-19T11:28:21-07:00
      DOI: 10.1073/pnas.2100566118
      Issue No: Vol. 118, No. 43 (2021)
       
  • A new regime of heme-dependent aromatic oxygenase superfamily
           [Biochemistry]

    • Free pre-print version: Loading...

      Authors: Inchul Shin; Yifan Wang, Aimin Liu
      Abstract: Two histidine-ligated heme-dependent monooxygenase proteins, TyrH and SfmD, have recently been found to resemble enzymes from the dioxygenase superfamily currently named after tryptophan 2,3-dioxygenase (TDO), that is, the TDO superfamily. These latest findings prompted us to revisit the structure and function of the superfamily. The enzymes in this superfamily share...
      Keywords: Biochemistry, Chemistry, Perspectives
      PubDate: 2021-10-19T11:28:21-07:00
      DOI: 10.1073/pnas.2106561118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Auditory tuning in the bushcricket miniature hearing organ [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Thorin Jonsson
      Abstract: When the air of warm summer nights is buzzing and whirring with the songs of male bushcrickets (also known as katydids), our ears perform a series of tasks enabling us to perceive these acoustic communication signals. Airborne sound waves travel through the ear canal of the outer ear and impinge...
      Keywords: Neuroscience, Commentaries
      PubDate: 2021-10-19T11:28:21-07:00
      DOI: 10.1073/pnas.2115779118
      Issue No: Vol. 118, No. 43 (2021)
       
  • COVID-19 lockdowns drive decline in active fires in southeastern United
           States [Sustainability Science]

    • Free pre-print version: Loading...

      Authors: Benjamin Poulter; Patrick H. Freeborn, W. Matt Jolly, J. Morgan Varner
      Abstract: Fire is a common ecosystem process in forests and grasslands worldwide. Increasingly, ignitions are controlled by human activities either through suppression of wildfires or intentional ignition of prescribed fires. The southeastern United States leads the nation in prescribed fire, burning ca. 80% of the country’s extent annually. The COVID-19 pandemic...
      Keywords: Ecology, Sustainability Science
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2105666118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Proton exchange membrane fuel cells powered with both CO and H2
           [Chemistry]

    • Free pre-print version: Loading...

      Authors: Xian Wang; Yang Li, Ying Wang, Hao Zhang, Zhao Jin, Xiaolong Yang, Zhaoping Shi, Liang Liang, Zhijian Wu, Zheng Jiang, Wei Zhang, Changpeng Liu, Wei Xing, Junjie Ge
      Abstract: The CO electrooxidation is long considered invincible in the proton exchange membrane fuel cell (PEMFC), where even a trace level of CO in H2 seriously poisons the anode catalysts and leads to huge performance decay. Here, we describe a class of atomically dispersed IrRu-N-C anode catalysts capable of oxidizing CO,...
      Keywords: Chemistry
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2107332118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Critical regulation of follicular helper T cell differentiation and
           function by G{alpha}13 signaling [Immunology and Inflammation]

    • Free pre-print version: Loading...

      Authors: Da-Sol Kuen; Miso Park, Heeju Ryu, Garam Choi, Young-Hye Moon, Jae-Ouk Kim, Keon Wook Kang, Sang Geon Kim, Yeonseok Chung
      Abstract: GPCR-Gα protein–mediated signal transduction contributes to spatiotemporal interactions between immune cells to fine-tune and facilitate the process of inflammation and host protection. Beyond this, however, how Gα proteins contribute to the helper T cell subset differentiation and adaptive response have been underappreciated. Here, we found that Gα13 signaling in T...
      Keywords: Immunology and Inflammation
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2108376118
      Issue No: Vol. 118, No. 43 (2021)
       
  • The genetic source tracking of human urinary exosomes [Genetics]

    • Free pre-print version: Loading...

      Authors: Qingfu Zhu; Liming Cheng, Chunyu Deng, Liu Huang, Jiaoyuan Li, Yong Wang, Meng Li, Qinsi Yang, Xianjun Dong, Jianzhong Su, Luke P. Lee, Fei Liu
      Abstract: The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic...
      Keywords: Genetics, Brief Reports
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2108876118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Neural mechanisms of deliberate dishonesty: Dissociating deliberation from
           other control processes during dishonest behaviors [Psychological and
           Cognitive Sciences]

    • Free pre-print version: Loading...

      Authors: Liyang Sai; Gabriele Bellucci, Chongxiang Wang, Genyue Fu, Julia A. Camilleri, Simon B. Eickhoff, Frank Krueger
      Abstract: Numerous studies have sought proof of whether people are genuinely honest by testing whether cognitive control mechanisms are recruited during honest and dishonest behaviors. The underlying assumption is: Deliberate behaviors require cognitive control to inhibit intuitive responses. However, cognitive control during honest and dishonest behaviors can be required for other...
      Keywords: Psychological and Cognitive Sciences, Brief Reports
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2109208118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Digital printing of shape-morphing natural materials [Engineering]

    • Free pre-print version: Loading...

      Authors: Ze Zhao; Jatin Kumar, Youngkyu Hwang, Jingyu Deng, Mohammed Shahrudin Bin Ibrahim, Changjin Huang, Subra Suresh, Nam-Joon Cho
      Abstract: We demonstrate how programmable shape evolution and deformation can be induced in plant-based natural materials through standard digital printing technologies. With nonallergenic pollen paper as the substrate material, we show how specific geometrical features and architectures can be custom designed through digital printing of patterns to modulate hygrophobicity, geometry, and...
      Keywords: Engineering
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2113715118
      Issue No: Vol. 118, No. 43 (2021)
       
  • The area rule for circulation in three-dimensional turbulence [Applied
           Physical Sciences]

    • Free pre-print version: Loading...

      Authors: Kartik P. Iyer; Sachin S. Bharadwaj, Katepalli R. Sreenivasan
      Abstract: An important idea underlying a plausible dynamical theory of circulation in three-dimensional turbulence is the so-called area rule, according to which the probability density function (PDF) of the circulation around closed loops depends only on the minimal area of the loop, not its shape. We assess the robustness of the...
      Keywords: Applied Physical Sciences
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2114679118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the
           Pro/N-degron pathway [Biochemistry]

    • Free pre-print version: Loading...

      Authors: Shun-Jia Chen; Leehyeon Kim, Hyun Kyu Song, Alexander Varshavsky
      Abstract: N-degron pathways are proteolytic systems that recognize proteins bearing N-terminal (Nt) degradation signals (degrons) called N-degrons. Our previous work identified Gid4 as a recognition component (N-recognin) of the Saccharomyces cerevisiae proteolytic system termed the proline (Pro)/N-degron pathway. Gid4 is a subunit of the oligomeric glucose-induced degradation (GID) ubiquitin ligase. Gid4...
      Keywords: Biochemistry
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2115430118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Explanations for tropical diversity gradients are rooted in the deep past
           [Evolution]

    • Free pre-print version: Loading...

      Authors: Erin E. Saupe
      Abstract: Species are distributed unevenly across the surface of Earth. More species are found in the warm tropics than in cool temperate regions. This pattern was first recognized over two centuries ago by Alexander von Humboldt, with his observation “The nearer we approach the tropics, the greater the increase in the...
      Keywords: Evolution, Commentaries
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2116942118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Correction for Donate et al., Cigarette smoke induces miR-132 in Th17
           cells that enhance osteoclastogenesis in inflammatory arthritis
           [Immunology and Inflammation]

    • Free pre-print version: Loading...

      Abstract: IMMUNOLOGY AND INFLAMMATION. Correction for “Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis,” by Paula B. Donate, Kalil Alves de Lima, Raphael S. Peres, Fausto Almeida, Sandra Y. Fukada, Tarcilia A. Silva, Daniele C. Nascimento, Nerry T. Cecilio, Jhimmy Talbot, Rene D. Oliveira, Geraldo A....
      Keywords: Immunology and Inflammation, Corrections
      PubDate: 2021-10-18T12:06:25-07:00
      DOI: 10.1073/pnas.2117163118
      Issue No: Vol. 118, No. 43 (2021)
       
  • People are more tolerant of inequality when it is expressed in terms of
           individuals rather than groups at the top [Psychological and Cognitive
           Sciences]

    • Free pre-print version: Loading...

      Authors: Jesse Walker; Stephanie J. Tepper, Thomas Gilovich
      Abstract: Despite the ever-growing economic gap between the very wealthy and the rest of the population, support for redistributive policies tends to be low. This research tested whether people’s tolerance of inequality differs when it is represented in terms of a successful individual versus a group of people at the top...
      Keywords: Psychological and Cognitive Sciences
      PubDate: 2021-10-18T12:06:24-07:00
      DOI: 10.1073/pnas.2100430118
      Issue No: Vol. 118, No. 43 (2021)
       
  • No aggregate deforestation reductions from rollout of community land
           titles in Indonesia yet [Sustainability Science]

    • Free pre-print version: Loading...

      Authors: Sebastian Kraus; Jacqueline Liu, Nicolas Koch, Sabine Fuss
      Abstract: In Indonesia, 60 million people live within 1 km of state forest. The government of Indonesia plans to grant community titles for 12.7 million hectares of land to communities living in and around forests. These titles allow for using nontimber forest products, practicing agroforestry, operating tourism businesses, and selective logging...
      Keywords: Brief Reports, Sustainability Science
      PubDate: 2021-10-18T12:06:24-07:00
      DOI: 10.1073/pnas.2100741118
      Issue No: Vol. 118, No. 43 (2021)
       
  • The membrane-linked adaptor FRS2{beta} fashions a cytokine-rich
           inflammatory microenvironment that promotes breast cancer carcinogenesis
           [Medical Sciences]

    • Free pre-print version: Loading...

      Authors: Yasuto Takeuchi; Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Minoru Terashima, Yuming Wang, Mengjiao Li, Reiko Sakamoto, Mizuki Yamamoto, Naoki Itano, Yusuke Inoue, Masataka Ito, Nobuaki Yoshida, Jun-ichiro Inoue, Koichi Akashi, Hideyuki Saya, Koji Fujita, Masahiko Kuroda, Issay Kitabayashi, Dominic Voon, Takeshi Suzuki, Arinobu Tojo, Noriko Gotoh
      Abstract: Although it is held that proinflammatory changes precede the onset of breast cancer, the underlying mechanisms remain obscure. Here, we demonstrate that FRS2β, an adaptor protein expressed in a small subset of epithelial cells, triggers the proinflammatory changes that induce stroma in premalignant mammary tissues and is responsible for the...
      Keywords: Medical Sciences
      PubDate: 2021-10-18T12:06:24-07:00
      DOI: 10.1073/pnas.2103658118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Miniaturized wireless, skin-integrated sensor networks for quantifying
           full-body movement behaviors and vital signs in infants [Engineering]

    • Free pre-print version: Loading...

      Authors: Hyoyoung Jeong; Sung Soo Kwak, Seokwoo Sohn, Jong Yoon Lee, Young Joong Lee, Megan K. O’Brien, Yoonseok Park, Raudel Avila, Jin–Tae Kim, Jae–Young Yoo, Masahiro Irie, Hokyung Jang, Wei Ouyang, Nicholas Shawen, Youn J. Kang, Seung Sik Kim, Andreas Tzavelis, KunHyuck Lee, Rachel A. Andersen, Yonggang Huang, Arun Jayaraman, Matthew M. Davis, Thomas Shanley, Lauren S. Wakschlag, Sheila Krogh–Jespersen, Shuai Xu, Shirley W. Ryan, Richard L. Lieber, John A. Rogers
      Abstract: Early identification of atypical infant movement behaviors consistent with underlying neuromotor pathologies can expedite timely enrollment in therapeutic interventions that exploit inherent neuroplasticity to promote recovery. Traditional neuromotor assessments rely on qualitative evaluations performed by specially trained personnel, mostly available in tertiary medical centers or specialized facilities. Such approaches are...
      Keywords: Engineering
      PubDate: 2021-10-18T12:06:24-07:00
      DOI: 10.1073/pnas.2104925118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Early warm-season mesoscale convective systems dominate soil
           moisture-precipitation feedback for summer rainfall in central United
           States [Earth, Atmospheric, and Planetary Sciences]

    • Free pre-print version: Loading...

      Authors: Huancui Hu; L. Ruby Leung, Zhe Feng
      Abstract: Land–atmosphere interactions play an important role in summer rainfall in the central United States, where mesoscale convective systems (MCSs) contribute to 30 to 70% of warm-season precipitation. Previous studies of soil moisture–precipitation feedbacks focused on the total precipitation, confounding the distinct roles of rainfall from different convective storm types. Here,...
      Keywords: Earth, Atmospheric, and Planetary Sciences
      PubDate: 2021-10-18T12:06:24-07:00
      DOI: 10.1073/pnas.2105260118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Visual exposure enhances stimulus encoding and persistence in primary
           cortex [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Andreea Lazar; Christopher Lewis, Pascal Fries, Wolf Singer, Danko Nikolic
      Abstract: The brain adapts to the sensory environment. For example, simple sensory exposure can modify the response properties of early sensory neurons. How these changes affect the overall encoding and maintenance of stimulus information across neuronal populations remains unclear. We perform parallel recordings in the primary visual cortex of anesthetized cats...
      Keywords: Neuroscience
      PubDate: 2021-10-18T12:06:24-07:00
      DOI: 10.1073/pnas.2105276118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Retraction for Start et al., Physiology underlies the assembly of
           ecological communities [Retractions]

    • Free pre-print version: Loading...

      Authors: Shannon McCauley; Benjamin Gilbert
      Abstract: ECOLOGY Retraction for “Physiology underlies the assembly of ecological communities,” by Denon Start, Shannon McCauley, and Benjamin Gilbert, which was first published May 21, 2018; 10.1073/pnas.1802091115 (Proc. Natl. Acad. Sci. U.S.A. 115, 6016–6021). The undersigned authors wish to retract this article and note the following: “This paper tested the relationship...
      PubDate: 2021-10-14T12:53:48-07:00
      DOI: 10.1073/pnas.2117483118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Mapping the climate risk for European fisheries [Applied Biological
           Sciences]

    • Free pre-print version: Loading...

      Authors: Malin L. Pinsky
      Abstract: With fires, floods, storms surges, and heatwaves becoming dismayingly common because of climate change, how can societies adapt to these and further changes' In this context, fisheries have emerged as the proverbial canary in the coalmine and an important test case for the rest of society. The reason is, in...
      Keywords: Applied Biological Sciences, Commentaries, Sustainability Science
      PubDate: 2021-10-13T12:34:52-07:00
      DOI: 10.1073/pnas.2115997118
      Issue No: Vol. 118, No. 43 (2021)
       
  • A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV
           viral entry and protect human epithelial lung cells [Chemistry]

    • Free pre-print version: Loading...

      Authors: Matthew Mahoney; Vishnu C. Damalanka, Michael A. Tartell, Dong hee Chung, Andre Luiz Lourenco, Dustin Pwee, Anne E. Mayer Bridwell, Markus Hoffmann, Jorine Voss, Partha Karmakar, Nurit P. Azouz, Andrea M. Klingler, Paul W. Rothlauf, Cassandra E. Thompson, Melody Lee, Lidiȷa Klampfer, Christina L. Stallings, Marc E. Rothenberg, Stefan Pohlmann, Sean P. J. Whelan, Anthony J. O’Donoghue, Charles S. Craik, James W. Janetka
      Abstract: The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of other coronaviruses and is essential for viral spread in the lung. Utilizing rational structure-based drug design (SBDD) coupled to...
      Keywords: Chemistry, Medical Sciences, Coronavirus (COVID-19)
      PubDate: 2021-10-11T12:40:08-07:00
      DOI: 10.1073/pnas.2108728118
      Issue No: Vol. 118, No. 43 (2021)
       
  • COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological
           conditions [Microbiology]

    • Free pre-print version: Loading...

      Authors: Emiko Urano; Tomotaka Okamura, Chikako Ono, Shiori Ueno, Satoshi Nagata, Haruhiko Kamada, Mahoko Higuchi, Mugi Furukawa, Wataru Kamitani, Yoshiharu Matsuura, Yoshihiro Kawaoka, Yasuhiro Yasutomi
      Abstract: The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health and life. A useful pathological animal model accurately reflecting human pathology is needed to overcome the COVID-19 crisis. In the present study, COVID-19 cynomolgus monkey models including monkeys with underlying diseases causing severe...
      Keywords: Microbiology, Coronavirus (COVID-19)
      PubDate: 2021-10-08T12:01:36-07:00
      DOI: 10.1073/pnas.2104847118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Distant residues modulate conformational opening in SARS-CoV-2 spike
           protein [Biophysics and Computational Biology]

    • Free pre-print version: Loading...

      Authors: Dhiman Ray; Ly Le, Ioan Andricioaei
      Abstract: Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves the attachment of the receptor-binding domain (RBD) of its spike proteins to the ACE2 receptors on the peripheral membrane of host cells. Binding is initiated by a down-to-up conformational change in the spike protein, the change that presents the RBD...
      Keywords: Biophysics and Computational Biology, Coronavirus (COVID-19)
      PubDate: 2021-10-06T12:03:10-07:00
      DOI: 10.1073/pnas.2100943118
      Issue No: Vol. 118, No. 43 (2021)
       
  • Retraction for Cabral et al., A global network of marine protected areas
           for food [Retractions]

    • Free pre-print version: Loading...

      Abstract: ECOLOGY, SUSTAINABILITY SCIENCE Retraction for “A global network of marine protected areas for food,” by Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, and Steven D. Gaines, which was first published October 26, 2020; 10.1073/pnas.2000174117 (Proc. Natl. Acad. Sci. U.S.A. 117, 28134–28139)....
      PubDate: 2021-10-06T12:03:10-07:00
      DOI: 10.1073/pnas.2117750118
      Issue No: Vol. 118, No. 43 (2021)
       
  • In This Issue [This Week in PNAS]

    • Free pre-print version: Loading...

      Abstract: ECOLOGY Mating pairs of desert locusts. Preventing mating harassment in desert locusts In nonhuman animal societies, males often attempt to maximize fitness by fertilizing a large number of females, often resulting in harassment of females and competition among males. Although females of some species exhibit behaviors that mitigate mating antagonism,...
      Keywords: In This Issue
      PubDate: 2021-10-19T08:10:23-07:00
      DOI: 10.1073/iti4221118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Molecular insights into mechanisms of GPCR hijacking by Staphylococcus
           aureus [Biochemistry]

    • Free pre-print version: Loading...

      Authors: Claire M. Grison; Paul Lambey, Sylvain Jeannot, Elise Del Nero, Simon Fontanel, Fanny Peysson, Joyce Heuninck, Remy Sounier, Thierry Durroux, Cedric Leyrat, Sebastien Granier, Cherine Bechara
      Abstract: Atypical chemokine receptor 1 (ACKR1) is a G protein–coupled receptor (GPCR) targeted by Staphylococcus aureus bicomponent pore-forming leukotoxins to promote bacterial growth and immune evasion. Here, we have developed an integrative molecular pharmacology and structural biology approach in order to characterize the effect of leukotoxins HlgA and HlgB on ACKR1...
      Keywords: Biochemistry
      PubDate: 2021-10-18T12:03:03-07:00
      DOI: 10.1073/pnas.2108856118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Ultrafast synthesis of hard carbon anodes for sodium-ion batteries
           [Chemistry]

    • Free pre-print version: Loading...

      Authors: Yichao Zhen; Yang Chen, Feng Li, Zhenyu Guo, Zhensheng Hong, Maria-Magdalena Titirici
      Abstract: Hard carbons (HCs) are a significantly promising anode material for alkali metal-ion batteries. However, long calcination time and much energy consumption are required for the traditional fabrication way, resulting in an obstacle for high-throughput synthesis and structure regulation of HCs. Herein, we report an emerging sintering method to rapidly fabricate...
      Keywords: Chemistry
      PubDate: 2021-10-18T12:03:03-07:00
      DOI: 10.1073/pnas.2111119118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Spatial transcriptomics reveals a role for sensory nerves in preserving
           cranial suture patency through modulation of BMP/TGF-{beta} signaling
           [Developmental Biology]

    • Free pre-print version: Loading...

      Authors: Robert J. Tower; Zhu Li, Yu-Hao Cheng, Xue-Wei Wang, Labchan Rajbhandari, Qian Zhang, Stefano Negri, Cedric R. Uytingco, Arun Venkatesan, Feng-Quan Zhou, Patrick Cahan, Aaron W. James, Thomas L. Clemens
      Abstract: The patterning and ossification of the mammalian skeleton requires the coordinated actions of both intrinsic bone morphogens and extrinsic neurovascular signals, which function in a temporal and spatial fashion to control mesenchymal progenitor cell (MPC) fate. Here, we show the genetic inhibition of tropomyosin receptor kinase A (TrkA) sensory nerve...
      Keywords: Developmental Biology
      PubDate: 2021-10-18T12:03:03-07:00
      DOI: 10.1073/pnas.2103087118
      Issue No: Vol. 118, No. 42 (2021)
       
  • The mesoscale order of nacreous pearls [Engineering]

    • Free pre-print version: Loading...

      Authors: Jiseok Gim; Alden Koch, Laura M. Otter, Benjamin H. Savitzky, Sveinung Erland, Lara A. Estroff, Dorrit E. Jacob, Robert Hovden
      Abstract: A pearl’s distinguished beauty and toughness are attributable to the periodic stacking of aragonite tablets known as nacre. Nacre has naturally occurring mesoscale periodicity that remarkably arises in the absence of discrete translational symmetry. Gleaning the inspiring biomineral design of a pearl requires quantifying its structural coherence and understanding the...
      Keywords: Engineering
      PubDate: 2021-10-18T12:03:03-07:00
      DOI: 10.1073/pnas.2107477118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Trained innate immunity, long-lasting epigenetic modulation, and skewed
           myelopoiesis by heme [Immunology and Inflammation]

    • Free pre-print version: Loading...

      Authors: Elisa Jentho; Cristian Ruiz-Moreno, Boris Novakovic, Ioannis Kourtzelis, Wout. L. Megchelenbrink, Rui Martins, Triantafyllos Chavakis, Miguel P. Soares, Lydia Kalafati, Joel Guerra, Franziska Roestel, Peter Bohm, Maren Godmann, Tatyana Grinenko, Anne Eugster, Martina Beretta, Leo A. B. Joosten, Mihai G. Netea, Michael Bauer, Hendrik G. Stunnenberg, Sebastian Weis
      Abstract: Trained immunity defines long-lasting adaptations of innate immunity based on transcriptional and epigenetic modifications of myeloid cells and their bone marrow progenitors [M. Divangahi et al., Nat. Immunol. 22, 2–6 (2021)]. Innate immune cells, however, do not exclusively differentiate between foreign and self but also react to host-derived molecules referred...
      Keywords: Immunology and Inflammation
      PubDate: 2021-10-18T12:03:03-07:00
      DOI: 10.1073/pnas.2102698118
      Issue No: Vol. 118, No. 42 (2021)
       
  • A specialized spinal circuit for command amplification and directionality
           during escape behavior [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Na N. Guan; Lulu Xu, Tianrui Zhang, Chun-Xiao Huang, Zhen Wang, Elin Dahlberg, Haoyu Wang, Fangfang Wang, Irene Pallucchi, Yunfeng Hua, Abdeljabbar El Manira, Jianren Song
      Abstract: In vertebrates, action selection often involves higher cognition entailing an evaluative process. However, urgent tasks, such as defensive escape, require an immediate implementation of the directionality of escape trajectory, necessitating local circuits. Here we reveal a specialized spinal circuit for the execution of escape direction in adult zebrafish. A central...
      Keywords: Neuroscience
      PubDate: 2021-10-18T12:03:03-07:00
      DOI: 10.1073/pnas.2106785118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Forestalling age-impaired angiogenesis and blood flow by targeting NOX:
           Interplay of NOX1, IL-6, and SASP in propagating cell senescence [Medical
           Sciences]

    • Free pre-print version: Loading...

      Authors: Yao Li; Damir Kračun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St. Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes–Pagano, Patrick J. Pagano
      Abstract: In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and cellular senescence. Thus, such species have emerged as putative provocateurs and targets for senolysis, and a clearer understanding of their molecular origin and regulation...
      Keywords: Medical Sciences
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2015666118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Endogenous cannabinoids are required for MC4R-mediated control of energy
           homeostasis [Medical Sciences]

    • Free pre-print version: Loading...

      Authors: Yu Yong; Isin Cakir, Pauline Lining Pan, Jessica E. Biddinger, Rebecca J. Bluett, Ken Mackie, Nathan Bingham, Sachin Patel, Masoud Ghamari-Langroudi
      Abstract: Hypothalamic regulation of feeding and energy expenditure is a fundamental and evolutionarily conserved neurophysiological process critical for survival. Dysregulation of these processes, due to environmental or genetic causes, can lead to a variety of pathological conditions ranging from obesity to anorexia. Melanocortins and endogenous cannabinoids (eCBs) have been implicated in...
      Keywords: Medical Sciences
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2015990118
      Issue No: Vol. 118, No. 42 (2021)
       
  • A pair of dopamine neurons mediate chronic stress signals to induce
           learning deficit in Drosophila melanogaster [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Jia Jia; Lei He, Junfei Yang, Yichun Shuai, Jingjing Yang, Yalan Wu, Xin Liu, Tianli Chen, Guaxiu Wang, Xingyu Wang, Xiaoxu Song, Zhaowen Ding, Yan Zhu, Li Zhang, Peng Chen, Hongtao Qin
      Abstract: Chronic stress could induce severe cognitive impairments. Despite extensive investigations in mammalian models, the underlying mechanisms remain obscure. Here, we show that chronic stress could induce dramatic learning and memory deficits in Drosophila melanogaster. The chronic stress–induced learning deficit (CSLD) is long lasting and associated with other depression-like behaviors. We...
      Keywords: Neuroscience
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2023674118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast
           agents [Chemistry]

    • Free pre-print version: Loading...

      Authors: He Wei; Agata Wiśniowska, Jingxuan Fan, Peter Harvey, Yuanyuan Li, Victoria Wu, Eric C. Hansen, Juanye Zhang, Michael G. Kaul, Abigail M Frey, Gerhard Adam, Anatoly I. Frenkel, Moungi G. Bawendi, Alan Jasanoff
      Abstract: Magnetic nanoparticles are robust contrast agents for MRI and often produce particularly strong signal changes per particle. Leveraging these effects to probe cellular- and molecular-level phenomena in tissue can, however, be hindered by the large sizes of typical nanoparticle contrast agents. To address this limitation, we introduce single-nanometer iron oxide...
      Keywords: Chemistry, Medical Sciences
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2102340118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Leishmania type II dehydrogenase is essential for parasite viability
           irrespective of the presence of an active complex I [Microbiology]

    • Free pre-print version: Loading...

      Authors: Margarida Duarte; Cleide Ferreira, Gurleen Kaur Khandpur, Tamara Flohr, Jannik Zimmermann, Helena Castro, Johannes M. Herrmann, Bruce Morgan, Ana M. Tomas
      Abstract: Type II NADH dehydrogenases (NDH2) are monotopic enzymes present in the external or internal face of the mitochondrial inner membrane that contribute to NADH/NAD+ balance by conveying electrons from NADH to ubiquinone without coupled proton translocation. Herein, we characterize the product of a gene present in all species of the...
      Keywords: Microbiology
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2103803118
      Issue No: Vol. 118, No. 42 (2021)
       
  • A cell-ECM mechanism for connecting the ipsilateral eye to the brain
           [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Jianmin Su; Ubadah Sabbagh, Yanping Liang, Lucie Oleȷnikova, Karen G. Dixon, Ashley L. Russell, Jiang Chen, Yuchin Albert Pan, Jason W. Triplett, Michael A. Fox
      Abstract: Information about features in the visual world is parsed by circuits in the retina and is then transmitted to the brain by distinct subtypes of retinal ganglion cells (RGCs). Axons from RGC subtypes are stratified in retinorecipient brain nuclei, such as the superior colliculus (SC), to provide a segregated relay...
      Keywords: Neuroscience
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2104343118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Bioinspired micro/nanomotor with visible light energy-dependent forward,
           reverse, reciprocating, and spinning schooling motion [Applied Physical
           Sciences]

    • Free pre-print version: Loading...

      Authors: Jintao Tong; Dalei Wang, Ye Liu, Xin Lou, Jiwei Jiang, Bin Dong, Renfeng Dong, Mingcheng Yang
      Abstract: In nature, microorganisms could sense the intensity of the incident visible light and exhibit bidirectional (positive or negative) phototaxis. However, it is still challenging to achieve the similar biomimetic phototaxis for the artificial micro/nanomotor (MNM) counterparts with the size from a few nanometers to a few micrometers. In this work,...
      Keywords: Applied Physical Sciences
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2104481118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Changes in selection pressure can facilitate hybridization during
           biological invasion in a Cuban lizard [Evolution]

    • Free pre-print version: Loading...

      Authors: Dan G. Bock; Simon Baeckens, Jessica N. Pita-Aquino, Zachary A. Chejanovski, Sozos N. Michaelides, Pavitra Muralidhar, Oriol Lapiedra, Sungdae Park, Douglas B. Menke, Anthony J. Geneva, Jonathan B. Losos, Jason J. Kolbe
      Abstract: Hybridization is among the evolutionary mechanisms most frequently hypothesized to drive the success of invasive species, in part because hybrids are common in invasive populations. One explanation for this pattern is that biological invasions coincide with a change in selection pressures that limit hybridization in the native range. To investigate...
      Keywords: Evolution
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2108638118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Swarm intelligence begins now or never [Social Sciences]

    • Free pre-print version: Loading...

      Authors: Kang Hao Cheong; Michael C. Jones
      Abstract: In vivid detail, Bak-Coleman et al. (1) describe explosively multiplicative global pathologies of scale posing existential risk to humanity. They argue that the study of collective behavior in the age of digital social media must rise to a “crisis discipline” dedicated to averting global ruin through the adaptive manipulation of...
      Keywords: Letters, Letters and Replies, Sustainability Science
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2113678118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Curvature thylakoid 1 proteins modulate prolamellar body morphology and
           promote organized thylakoid biogenesis in Arabidopsis thaliana [Plant
           Biology]

    • Free pre-print version: Loading...

      Authors: Omar Sandoval–Ibanez; Anurag Sharma, Michał Bykowski, Guillem Borras–Gas, James B. Y. H. Behrendorff, Silas Mellor, Klaus Qvortrup, Julian C. Verdonk, Ralph Bock, Łucȷa Kowalewska, Mathias Pribil
      Abstract: The term “de-etiolation” refers to the light-dependent differentiation of etioplasts to chloroplasts in angiosperms. The underlying process involves reorganization of prolamellar bodies (PLBs) and prothylakoids into thylakoids, with concurrent changes in protein, lipid, and pigment composition, which together lead to the assembly of active photosynthetic complexes. Despite the highly conserved...
      Keywords: Plant Biology
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2113934118
      Issue No: Vol. 118, No. 42 (2021)
       
  • The low-complexity domain of the FUS RNA binding protein self-assembles
           via the mutually exclusive use of two distinct cross-{beta} cores
           [Biochemistry]

    • Free pre-print version: Loading...

      Authors: Masato Kato; Steven L. McKnight
      Abstract: The low-complexity (LC) domain of the fused in sarcoma (FUS) RNA binding protein self-associates in a manner causing phase separation from an aqueous environment. Incubation of the FUS LC domain under physiologically normal conditions of salt and pH leads to rapid formation of liquid-like droplets that mature into a gel-like...
      Keywords: Biochemistry
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2114412118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Reply to Cheong and Jones: The role of science in responding to collective
           behavioral threats [Social Sciences]

    • Free pre-print version: Loading...

      Authors: Joseph B. Bak-Coleman; Carl T. Bergstrom
      Abstract: In our PNAS article “Stewardship of global collective behavior” (1), we describe the breakneck pace of recent innovations in information technology. This radical transformation has transpired not through a stewarded effort to improve information quality or to further human well-being. Rather, current technologies have been developed and deployed largely for...
      Keywords: Letters, Letters and Replies, Sustainability Science
      PubDate: 2021-10-15T14:12:54-07:00
      DOI: 10.1073/pnas.2114477118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Cadmium hijacks the high zinc response by binding and activating the
           HIZR-1 nuclear receptor [Genetics]

    • Free pre-print version: Loading...

      Authors: Brian J. Earley; Ciro Cubillas, Kurt Warnhoff, Raheel Ahmad, Alan Alcantar, Maximilian D. Lyon, Daniel L. Schneider, Kerry Kornfeld
      Abstract: Cadmium is an environmental pollutant and significant health hazard that is similar to the physiological metal zinc. In Caenorhabditis elegans, high zinc homeostasis is regulated by the high zinc activated nuclear receptor (HIZR-1) transcription factor. To define relationships between the responses to high zinc and cadmium, we analyzed transcription. Many...
      Keywords: Genetics
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2022649118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Timing outweighs magnitude of rainfall in shaping population dynamics of a
           small mammal species in steppe grassland [Population Biology]

    • Free pre-print version: Loading...

      Authors: Guoliang Li; Xinrong Wan, Baofa Yin, Wanhong Wei, Xianglei Hou, Xin Zhang, Erdenetuya Batsuren, Jidong Zhao, Shuli Huang, Xiaoming Xu, Jing Liu, Yiran Song, Arpat Ozgul, Christopher R. Dickman, Guiming Wang, Charles J. Krebs, Zhibin Zhang
      Abstract: Climate change–induced shifts in species phenology differ widely across trophic levels, which may lead to consumer–resource mismatches with cascading population and ecosystem consequences. Here, we examined the effects of different rainfall patterns (i.e., timing and amount) on the phenological asynchrony of population of a generalist herbivore and their food sources...
      Keywords: Population Biology
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2023691118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Genome evolution of the psammophyte Pugionium for desert adaptation and
           further speciation [Evolution]

    • Free pre-print version: Loading...

      Authors: Quanȷun Hu; Yazhen Ma, Terezie Mandakova, Sheng Shi, Chunlin Chen, Pengchuan Sun, Lei Zhang, Landi Feng, Yudan Zheng, Xiaoqin Feng, Wenȷie Yang, Jiebei Jiang, Ting Li, Pingping Zhou, Qiushi Yu, Dongshi Wan, Martin A. Lysak, Zhenxiang Xi, Eviatar Nevo, Jianquan Liu
      Abstract: Deserts exert strong selection pressures on plants, but the underlying genomic drivers of ecological adaptation and subsequent speciation remain largely unknown. Here, we generated de novo genome assemblies and conducted population genomic analyses of the psammophytic genus Pugionium (Brassicaceae). Our results indicated that this bispecific genus had undergone an allopolyploid...
      Keywords: Evolution
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2025711118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Neogene continental denudation and the beryllium conundrum [Earth,
           Atmospheric, and Planetary Sciences]

    • Free pre-print version: Loading...

      Authors: Shilei (李石磊) Li; Steven L. Goldstein, Maureen E. Raymo
      Abstract: Reconstructing Cenozoic history of continental silicate weathering is crucial for understanding Earth’s carbon cycle and greenhouse history. The question of whether continental silicate weathering increased during the late Cenozoic, setting the stage for glacial cycles, has remained controversial for decades. Whereas numerous independent proxies of weathering in ocean sediments (e.g.,...
      Keywords: Earth, Atmospheric, and Planetary Sciences
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2026456118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Stiffness of targeted layer-by-layer nanoparticles impacts elimination
           half-life, tumor accumulation, and tumor penetration [Applied Biological
           Sciences]

    • Free pre-print version: Loading...

      Authors: Stephanie M. Kong; Daniel F. Costa, Anna Jagielska, Krystyn J. Van Vliet, Paula T. Hammond
      Abstract: Nanoparticle (NP) stiffness has been shown to significantly impact circulation time and biodistribution in anticancer drug delivery. In particular, the relationship between particle stiffness and tumor accumulation and penetration in vivo is an important phenomenon to consider in optimizing NP-mediated tumor delivery. Layer-by-layer (LbL) NPs represent a promising class of...
      Keywords: Applied Biological Sciences
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2104826118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Spatial social dilemmas promote diversity [Social Sciences]

    • Free pre-print version: Loading...

      Authors: Christoph Hauert; Michael Doebeli
      Abstract: Cooperative investments in social dilemmas can spontaneously diversify into stably coexisting high and low contributors in well-mixed populations. Here we extend the analysis to emerging diversity in (spatially) structured populations. Using pair approximation, we derive analytical expressions for the invasion fitness of rare mutants in structured populations, which then yields...
      Keywords: Evolution, Social Sciences
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2105252118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Totimorphic assemblies from neutrally stable units [Engineering]

    • Free pre-print version: Loading...

      Authors: Gaurav Chaudhary; S. Ganga Prasath, Edward Soucy, L. Mahadevan
      Abstract: Inspired by the quest for shape-shifting structures in a range of applications, we show how to create morphable structural materials using a neutrally stable unit cell as a building block. This unit cell is a self-stressed hinged structure with a one-parameter family of morphing motions that are all energetically equivalent....
      Keywords: Engineering
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2107003118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Low-bias ncRNA libraries using ordered two-template relay: Serial template
           jumping by a modified retroelement reverse transcriptase [Biochemistry]

    • Free pre-print version: Loading...

      Authors: Heather E. Upton; Lucas Ferguson, Morayma M. Temoche-Diaz, Xiao-Man Liu, Sydney C. Pimentel, Nicholas T. Ingolia, Randy Schekman, Kathleen Collins
      Abstract: Selfish, non-long terminal repeat (non-LTR) retroelements and mobile group II introns encode reverse transcriptases (RTs) that can initiate DNA synthesis without substantial base pairing of primer and template. Biochemical characterization of these enzymes has been limited by recombinant expression challenges, hampering understanding of their properties and the possible exploitation of...
      Keywords: Biochemistry
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2107900118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Prediction of unconventional magnetism in doped FeSb2 [Physics]

    • Free pre-print version: Loading...

      Authors: Igor I. Mazin; Klaus Koepernik, Michelle D. Johannes, Rafael Gonzalez–Hernandez, Libor Šmeȷkal
      Abstract: It is commonly believed that the energy bands of typical collinear antiferromagnets (AFs), which have zero net magnetization, are Kramers spin-degenerate. Kramers nondegeneracy is usually associated with a global time-reversal symmetry breaking (e.g., via ferromagnetism) or with a combination of spin–orbit interaction and broken spatial inversion symmetry. Recently, another type...
      Keywords: Physics
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2108924118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Inherent hepatocytic heterogeneity determines expression and retention of
           edited F9 alleles post-AAV/CRISPR infusion [Medical Sciences]

    • Free pre-print version: Loading...

      Authors: Qiang Wang; Lin Zhang, Guo-Wei Zhang, Jian-Hua Mao, Xiao-Dong Xi, Lu Jiang, Gang Lv, Jing Lu, Yan Shen, Zhu Chen, Jiang Zhu, Sai-Juan Chen
      Abstract: Infusing CRISPR/donor-loaded adeno-associated viral vectors (AAV/CRISPR) could enable in vivo hepatic gene editing to remedy hemophilia B (HB) with inherited deficiency of clotting factor IX (FIX). Yet, current regimens focus on correcting HB with simple mutations in the coding region of the F9, overlooking those carrying complicated mutations involving the...
      Keywords: Medical Sciences
      PubDate: 2021-10-14T12:53:51-07:00
      DOI: 10.1073/pnas.2110887118
      Issue No: Vol. 118, No. 42 (2021)
       
  • The human olfactory bulb processes odor valence representation and cues
           motor avoidance behavior [Psychological and Cognitive Sciences]

    • Free pre-print version: Loading...

      Authors: Behzad Iravani; Martin Schaefer, Donald A. Wilson, Artin Arshamian, Johan N. Lundstrom
      Abstract: Determining the valence of an odor to guide rapid approach–avoidance behavior is thought to be one of the core tasks of the olfactory system, and yet little is known of the initial neural mechanisms supporting this process or of its subsequent behavioral manifestation in humans. In two experiments, we measured...
      PubDate: 2021-10-13T12:34:44-07:00
      DOI: 10.1073/pnas.2101209118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Four-dimensional chromosome reconstruction elucidates the spatiotemporal
           reorganization of the mammalian X chromosome [Cell Biology]

    • Free pre-print version: Loading...

      Authors: Anna Lappala; Chen-Yu Wang, Andrea Kriz, Hunter Michalk, Kevin Tan, Jeannie T. Lee, Karissa Y. Sanbonmatsu
      Abstract: Chromosomes are segmented into domains and compartments, but how these structures are spatially related in three dimensions (3D) is unclear. Here, we developed tools that directly extract 3D information from Hi-C experiments and integrate the data across time. With our “4DHiC” method, we use X chromosome inactivation (XCI) as a...
      Keywords: Cell Biology
      PubDate: 2021-10-13T12:34:44-07:00
      DOI: 10.1073/pnas.2107092118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Frequency of enforcement is more important than the severity of punishment
           in reducing violation behaviors [Social Sciences]

    • Free pre-print version: Loading...

      Authors: Kinneret Teodorescu; Ori Plonsky, Shahar Ayal, Rachel Barkan
      Abstract: External enforcement policies aimed to reduce violations differ on two key components: the probability of inspection and the severity of the punishment. Different lines of research offer different insights regarding the relative importance of each component. In four studies, students and Prolific crowdsourcing participants (Ntotal = 816) repeatedly faced temptations...
      Keywords: Social Sciences
      PubDate: 2021-10-13T12:34:44-07:00
      DOI: 10.1073/pnas.2108507118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Surface equilibration mechanism controls the molecular packing of glassy
           molecular semiconductors at organic interfaces [Chemistry]

    • Free pre-print version: Loading...

      Authors: Marie E. Fiori; Kushal Bagchi, Michael F. Toney, M. D. Ediger
      Abstract: Glasses prepared by physical vapor deposition (PVD) are anisotropic, and the average molecular orientation can be varied significantly by controlling the deposition conditions. While previous work has characterized the average structure of thick PVD glasses, most experiments are not sensitive to the structure near an underlying substrate or interface. Given...
      Keywords: Chemistry
      PubDate: 2021-10-13T12:34:44-07:00
      DOI: 10.1073/pnas.2111988118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Opinion: Transformational opportunities for an equitable ocean commons
           [Environmental Sciences]

    • Free pre-print version: Loading...

      Authors: Joachim Claudet; Diva J. Amon, Robert Blasiak
      Abstract: A frontier mentality has been a defining aspect of human history. Often this sentiment is optimistically framed in the language of aspirations and opportunities. But it can also be accompanied by unsavory narratives of over-exploitation, inequity, and conflict (1). If any place on Earth can be considered a final frontier,...
      Keywords: Opinions, Environmental Sciences, Front Matter, Sustainability Science
      PubDate: 2021-10-13T12:34:44-07:00
      DOI: 10.1073/pnas.2117033118
      Issue No: Vol. 118, No. 42 (2021)
       
  • The association of opening K-12 schools with the spread of COVID-19 in the
           United States: County-level panel data analysis [Economic Sciences]

    • Free pre-print version: Loading...

      Authors: Victor Chernozhukov; Hiroyuki Kasahara, Paul Schrimpf
      Abstract: This paper empirically examines how the opening of K–12 schools is associated with the spread of COVID-19 using county-level panel data in the United States. As preliminary evidence, our event-study analysis indicates that cases and deaths in counties with in-person or hybrid opening relative to those with remote opening substantially...
      Keywords: Economic Sciences
      PubDate: 2021-10-12T11:49:31-07:00
      DOI: 10.1073/pnas.2103420118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Linking species traits and demography to explain complex temperature
           responses across levels of organization [Ecology]

    • Free pre-print version: Loading...

      Authors: Daniel J. Wieczynski; Pranav Singla, Adrian Doan, Alexandra Singleton, Ze-Yi Han, Samantha Votzke, Andrea Yammine, Jean P. Gibert
      Abstract: Microbial communities regulate ecosystem responses to climate change. However, predicting these responses is challenging because of complex interactions among processes at multiple levels of organization. Organismal traits that determine individual performance and ecological interactions are essential for scaling up environmental responses from individuals to ecosystems. We combine protist microcosm experiments...
      Keywords: Ecology
      PubDate: 2021-10-12T11:49:31-07:00
      DOI: 10.1073/pnas.2104863118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Synapse development is regulated by microglial THIK-1 K+ channels
           [Neuroscience]

    • Free pre-print version: Loading...

      Authors: Pablo Izquierdo; Hiroko Shiina, Chanawee Hirunpattarasilp, Grace Gillis, David Attwell
      Abstract: Microglia are the resident immune cells of the central nervous system. They constantly survey the brain parenchyma for redundant synapses, debris, or dying cells, which they remove through phagocytosis. Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Here, we...
      Keywords: Neuroscience
      PubDate: 2021-10-12T11:49:31-07:00
      DOI: 10.1073/pnas.2106294118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Dynamic changes in tRNA modifications and abundance during T cell
           activation [Cell Biology]

    • Free pre-print version: Loading...

      Authors: Roni Rak; Michal Polonsky, Inbal Eizenberg-Magar, Yufeng Mo, Yuriko Sakaguchi, Orel Mizrahi, Aharon Nachshon, Shlomit Reich-Zeliger, Noam Stern-Ginossar, Orna Dahan, Tsutomu Suzuki, Nir Friedman, Yitzhak Pilpel
      Abstract: The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA (transfer RNA) supply and mRNA (messenger RNA) demand during cancerous proliferation. Yet dynamic changes may also occur during physiologically normal proliferation, and these are less well characterized. We examined the...
      Keywords: Cell Biology
      PubDate: 2021-10-12T11:49:31-07:00
      DOI: 10.1073/pnas.2106556118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Spontaneous helielectric nematic liquid crystals: Electric analog to
           helimagnets [Physics]

    • Free pre-print version: Loading...

      Authors: Xiuhu Zhao; Junchen Zhou, Jinxing Li, Junichi Kougo, Zhe Wan, Mingjun Huang, Satoshi Aya
      Abstract: Recently, a type of ferroelectric nematic fluid has been discovered in liquid crystals in which the molecular polar nature at molecule level is amplified to macroscopic scales through a ferroelectric packing of rod-shaped molecules. Here, we report on the experimental proof of a polar chiral liquid matter state, dubbed helielectric...
      Keywords: Physics
      PubDate: 2021-10-12T11:49:31-07:00
      DOI: 10.1073/pnas.2111101118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Same gene, opposite sexes: Sex-specific divergent expression of a gene
           required for vertebrate fertilization [Genetics]

    • Free pre-print version: Loading...

      Authors: Enrica Bianchi
      Abstract: The vast majority of eukaryotes reproduce sexually; each species generates highly specialized cells with distinct morphological and functional characteristics that differ depending on the individual’s genetic sex. The male spermatozoon (sperm) is generally a motile cell that bears the paternal genome (1, 2), while the female oocyte usually is a...
      Keywords: Genetics, Commentaries
      PubDate: 2021-10-12T11:49:31-07:00
      DOI: 10.1073/pnas.2116001118
      Issue No: Vol. 118, No. 42 (2021)
       
  • When adaptive radiations collide: Different evolutionary trajectories
           between and within island and mainland lizard clades [Evolution]

    • Free pre-print version: Loading...

      Authors: Austin H. Patton; Luke J. Harmon, Maria del Rosario Castaneda, Hannah K. Frank, Colin M. Donihue, Anthony Herrel, Jonathan B. Losos
      Abstract: Oceanic islands are known as test tubes of evolution. Isolated and colonized by relatively few species, islands are home to many of nature’s most renowned radiations from the finches of the Galápagos to the silverswords of the Hawaiian Islands. Despite the evolutionary exuberance of insular life, island occupation has long...
      Keywords: Inaugural Articles, Evolution
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2024451118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Freeze tolerance influenced forest cover and hydrology during the
           Pennsylvanian [Earth, Atmospheric, and Planetary Sciences]

    • Free pre-print version: Loading...

      Authors: William J. Matthaeus; Sophia I. Macarewich, Jon D. Richey, Jonathan P. Wilson, Jennifer C. McElwain, Isabel P. Montanez, William A. DiMichele, Michael T. Hren, Christopher J. Poulsen, Joseph D. White
      Abstract: The distribution of forest cover alters Earth surface mass and energy exchange and is controlled by physiology, which determines plant environmental limits. Ancient plant physiology, therefore, likely affected vegetation-climate feedbacks. We combine climate modeling and ecosystem-process modeling to simulate arboreal vegetation in the late Paleozoic ice age. Using GENESIS V3...
      Keywords: Biophysics and Computational Biology, Earth, Atmospheric, and Planetary Sciences
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2025227118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Combined solar power and storage as cost-competitive and grid-compatible
           supply for China’s future carbon-neutral electricity system
           [Environmental Sciences]

    • Free pre-print version: Loading...

      Authors: Xi Lu; Shi Chen, Chris P. Nielsen, Chongyu Zhang, Jiacong Li, He Xu, Ye Wu, Shuxiao Wang, Feng Song, Chu Wei, Kebin He, Michael B. McElroy, Jiming Hao
      Abstract: As the world’s largest CO2 emitter, China’s ability to decarbonize its energy system strongly affects the prospect of achieving the 1.5 °C limit in global, average surface-temperature rise. Understanding technically feasible, cost-competitive, and grid-compatible solar photovoltaic (PV) power potentials spatiotemporally is critical for China’s future energy pathway. This study develops...
      Keywords: Environmental Sciences, Sustainability Science
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2103471118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Confederate monuments and the history of lynching in the American South:
           An empirical examination [Psychological and Cognitive Sciences]

    • Free pre-print version: Loading...

      Authors: Kyshia Henderson; Samuel Powers, Michele Claibourn, Jazmin L. Brown-Iannuzzi, Sophie Trawalter
      Abstract: The present work interrogates the history of Confederate memorializations by examining the relationship between these memorializations and lynching, an explicitly racist act of violence. We obtained and merged data on Confederate memorializations at the county level and lynching victims, also at the county level. We find that the number of...
      Keywords: Psychological and Cognitive Sciences
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2103519118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Density-dependent mating behaviors reduce male mating harassment in
           locusts [Ecology]

    • Free pre-print version: Loading...

      Authors: Koutaro Ould Maeno; Cyril Piou, Sidi Ould Ely, Sid’Ahmed Ould Mohamed, Mohamed El Hacen Jaavar, Said Ghaout, Mohamed Abdallahi Ould Babah Ebbe
      Abstract: Male mating harassment may occur when females and males do not have the same mating objectives. Communal animals need to manage the costs of male mating harassment. Here, we demonstrate how desert locusts in dense populations reduce such conflicts through behaviors. In transient populations (of solitarious morphology but gregarious behavior),...
      Keywords: Ecology
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2104673118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Development of an entirely plasmid-based reverse genetics system for
           12-segmented double-stranded RNA viruses [Microbiology]

    • Free pre-print version: Loading...

      Authors: Ryotaro Nouda; Shohei Minami, Yuta Kanai, Takahiro Kawagishi, Jeffery A. Nurdin, Moeko Yamasaki, Ryusei Kuwata, Hiroshi Shimoda, Ken Maeda, Takeshi Kobayashi
      Abstract: The family Reoviridae is a nonenveloped virus group with a double-stranded (ds) RNA genome comprising 9 to 12 segments. In the family Reoviridae, the genera Cardoreovirus, Phytoreovirus, Seadornavirus, Mycoreovirus, and Coltivirus contain virus species having 12-segmented dsRNA genomes. Reverse genetics systems used to generate recombinant infectious viruses are powerful tools...
      Keywords: Microbiology
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2105334118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Trusted authorities can change minds and shift norms during conflict
           [Psychological and Cognitive Sciences]

    • Free pre-print version: Loading...

      Authors: Graeme Blair; Rebecca Littman, Elizabeth R. Nugent, Rebecca Wolfe, Mohammed Bukar, Benjamin Crisman, Anthony Etim, Chad Hazlett, Jiyoung Kim
      Abstract: The reintegration of former members of violent extremist groups is a pressing policy challenge. Governments and policymakers often have to change minds among reticent populations and shift perceived community norms in order to pave the way for peaceful reintegration. How can they do so on a mass scale' Previous research...
      Keywords: Psychological and Cognitive Sciences
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2105570118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Opt-out choice framing attenuates gender differences in the decision to
           compete in the laboratory and in the field [Economic Sciences]

    • Free pre-print version: Loading...

      Authors: Joyce C. He; Sonia K. Kang, Nicola Lacetera
      Abstract: Research shows that women are less likely to enter competitions than men. This disparity may translate into a gender imbalance in holding leadership positions or ascending in organizations. We provide both laboratory and field experimental evidence that this difference can be attenuated with a default nudge—changing the choice to enter...
      Keywords: Economic Sciences
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2108337118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Rapid cloud removal of dimethyl sulfide oxidation products limits SO2 and
           cloud condensation nuclei production in the marine atmosphere [Earth,
           Atmospheric, and Planetary Sciences]

    • Free pre-print version: Loading...

      Authors: Gordon A. Novak; Charles H. Fite, Christopher D. Holmes, Patrick R. Veres, J. Andrew Neuman, Ian Faloona, Joel A. Thornton, Glenn M. Wolfe, Michael P. Vermeuel, Christopher M. Jernigan, Jeff Peischl, Thomas B. Ryerson, Chelsea R. Thompson, Ilann Bourgeois, Carsten Warneke, Georgios I. Gkatzelis, Mathew M. Coggon, Kanako Sekimoto, T. Paul Bui, Jonathan Dean-Day, Glenn S. Diskin, Joshua P. DiGangi, John B. Nowak, Richard H. Moore, Elizabeth B. Wiggins, Edward L. Winstead, Claire Robinson, K. Lee Thornhill, Kevin J. Sanchez, Samuel R. Hall, Kirk Ullmann, Maximilian Dollner, Bernadett Weinzierl, Donald R. Blake, Timothy H. Bertram
      Abstract: Oceans emit large quantities of dimethyl sulfide (DMS) to the marine atmosphere. The oxidation of DMS leads to the formation and growth of cloud condensation nuclei (CCN) with consequent effects on Earth’s radiation balance and climate. The quantitative assessment of the impact of DMS emissions on CCN concentrations necessitates a...
      Keywords: Earth, Atmospheric, and Planetary Sciences
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2110472118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Wind turbine icing characteristics and icing-induced power losses to
           utility-scale wind turbines [Engineering]

    • Free pre-print version: Loading...

      Authors: Linyue Gao; Hui Hu
      Abstract: A field campaign was carried out to investigate ice accretion features on large turbine blades (50 m in length) and to assess power output losses of utility-scale wind turbines induced by ice accretion. After a 30-h icing incident, a high-resolution digital camera carried by an unmanned aircraft system was used...
      Keywords: Engineering, Brief Reports
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2111461118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Correction for Sen et al., Sulfhydration of AKT triggers
           Tau-phosphorylation by activating glycogen synthase kinase 3{beta} in
           Alzheimer’s disease [Corrections]

    • Free pre-print version: Loading...

      Abstract: NEUROSCIENCE. Correction for “Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer’s disease,” by Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen, which was first published February 12, 2020; 10.1073/pnas.1916895117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4418–4427). The authors note that Fig. 2 appeared incorrectly....
      Keywords: Corrections
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2114879118
      Issue No: Vol. 118, No. 42 (2021)
       
  • QnAs with Jonathan B. Losos [QnAs]

    • Free pre-print version: Loading...

      Authors: Tinsley H. Davis
      Abstract: Jonathan B. Losos has long studied island-dwelling species. Elected to the National Academy of Sciences in 2018, Losos, an evolutionary ecologist at Washington University, has focused on Anolis lizards since high school. In his Inaugural Article (1), Losos, who is also the director of the Living Earth Collaborative, expands his...
      Keywords: QnAs, QnAs
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2116186118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Correction to Supporting Information for Rouse et al., Vocal learning and
           flexible rhythm pattern perception are linked: Evidence from songbirds [SI
           Correction]

    • Free pre-print version: Loading...

      Abstract: PSYCHOLOGICAL AND COGNITIVE SCIENCES Correction to Supporting Information for “Vocal learning and flexible rhythm pattern perception are linked: Evidence from songbirds,” by Andrew A. Rouse, Aniruddh D. Patel, and Mimi H. Kao, which published July 16, 2021; 10.1073/pnas.2026130118 (Proc. Natl. Acad. Sci. U.S.A. 118, e2026130118). The authors note that Supporting...
      Keywords: Corrections
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2116558118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Correction for Edwards et al., Contact with Child Protective Services is
           pervasive but unequally distributed by race and ethnicity in large US
           counties [Corrections]

    • Free pre-print version: Loading...

      Abstract: SOCIAL SCIENCES Correction for “Contact with Child Protective Services is pervasive but unequally distributed by race and ethnicity in large US counties,” by Frank Edwards, Sara Wakefield, Kieran Healy, and Christopher Wildeman, which published July 19, 2021; 10.1073/pnas.2106272118 (Proc. Natl. Acad. Sci. U.S.A. 118, e2106272118). The authors wish to note...
      Keywords: Corrections
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2116639118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Correction for Preisig et al., Selective modulation of interhemispheric
           connectivity by transcranial alternating current stimulation influences
           binaural integration [Neuroscience]

    • Free pre-print version: Loading...

      Abstract: NEUROSCIENCE, PSYCHOLOGICAL AND COGNITIVE SCIENCES Correction for “Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration,” by Basil C. Preisig, Lars Riecke, Matthias J. Sjerps, Anne Kösem, Benjamin R. Kop, Bob Bramson, Peter Hagoort, and Alexis Hervais-Adelman, which published February 10, 2021; 10.1073/pnas.2015488118 (Proc. Natl. Acad....
      Keywords: Neuroscience, Psychological and Cognitive Sciences, Corrections
      PubDate: 2021-10-11T12:40:11-07:00
      DOI: 10.1073/pnas.2116824118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Reduction in gene expression noise by targeted increase in accessibility
           at gene loci [Cell Biology]

    • Free pre-print version: Loading...

      Authors: LaTasha C. R. Fraser; Ryan J. Dikdan, Supravat Dey, Abhyudai Singh, Sanjay Tyagi
      Abstract: Many eukaryotic genes are expressed in randomly initiated bursts that are punctuated by periods of quiescence. Here, we show that the intermittent access of the promoters to transcription factors through relatively impervious chromatin contributes to this “noisy” transcription. We tethered a nuclease-deficient Cas9 fused to a histone acetyl transferase at...
      Keywords: Cell Biology
      PubDate: 2021-10-08T12:01:37-07:00
      DOI: 10.1073/pnas.2018640118
      Issue No: Vol. 118, No. 42 (2021)
       
  • T6SS translocates a micropeptide to suppress STING-mediated innate
           immunity by sequestering manganese [Microbiology]

    • Free pre-print version: Loading...

      Authors: Lingfang Zhu; Lei Xu, Chenguang Wang, Changfu Li, Mengyuan Li, Qinmeng Liu, Xiao Wang, Wenhui Yang, Damin Pan, Lingfei Hu, Yadong Yang, Zhiqiang Lu, Yao Wang, Dongsheng Zhou, Zhengfan Jiang, Xihui Shen
      Abstract: Cellular ionic concentrations are a central factor orchestrating host innate immunity, but no pathogenic mechanism that perturbs host innate immunity by directly targeting metal ions has yet been described. Here, we report a unique virulence strategy of Yersinia pseudotuberculosis (Yptb) involving modulation of the availability of Mn2+, an immunostimulatory metal...
      Keywords: Microbiology
      PubDate: 2021-10-08T12:01:37-07:00
      DOI: 10.1073/pnas.2103526118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Improving health and economic security by reducing work schedule
           uncertainty [Social Sciences]

    • Free pre-print version: Loading...

      Authors: Kristen Harknett; Daniel Schneider, Veronique Irwin
      Abstract: Work schedules in the service sector are routinely unstable and unpredictable, and this unpredictability may have harmful effects on health and economic insecurity. However, because schedule unpredictability often coincides with low wages and other dimensions of poor job quality, the causal effects of unpredictable work schedules are uncertain. Seattle’s Secure...
      Keywords: Social Sciences
      PubDate: 2021-10-08T12:01:37-07:00
      DOI: 10.1073/pnas.2107828118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Multiple hops move electrons from bacteria to rocks [Chemistry]

    • Free pre-print version: Loading...

      Authors: David N. Beratan
      Abstract: The central dogma of bioenergetics is that photons energize electrons in molecules, those electrons push protons, and proton concentration gradients forge chemical bonds. An understanding of how this works—at the level of electrons and atoms—is elusive, especially in organisms that live life on the edge of survival. How do bacteria...
      Keywords: Biophysics and Computational Biology, Chemistry, Commentaries
      PubDate: 2021-10-08T12:01:37-07:00
      DOI: 10.1073/pnas.2115620118
      Issue No: Vol. 118, No. 42 (2021)
       
  • A discrete-time infectious disease model for global pandemics [Applied
           Mathematics]

    • Free pre-print version: Loading...

      Authors: Abdul-Aziz Yakubu
      Abstract: The ongoing global pandemic of coronavirus (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised concerns about the effectiveness of current preventive pharmaceutical and nonpharmaceutical interventions (1). In addition, the upward global trends in the numbers of emerging and reemerging infectious diseases, as evidenced...
      Keywords: Applied Mathematics, Commentaries
      PubDate: 2021-10-08T12:01:37-07:00
      DOI: 10.1073/pnas.2116845118
      Issue No: Vol. 118, No. 42 (2021)
       
  • A mutation-mediated evolutionary adaptation of Zika virus in mosquito and
           mammalian host [Microbiology]

    • Free pre-print version: Loading...

      Authors: Xi Yu; Chao Shan, Yibin Zhu, Enhao Ma, Jinglin Wang, Penghua Wang, Pei-Yong Shi, Gong Cheng
      Abstract: Zika virus (ZIKV) caused millions of infections during its rapid and expansive spread from Asia to the Americas from 2015 to 2017. Here, we compared the infectivity of ZIKV mutants with individual stable substitutions which emerged throughout the Asian ZIKV lineage and were responsible for the explosive outbreaks in the...
      Keywords: Microbiology
      PubDate: 2021-10-07T12:36:56-07:00
      DOI: 10.1073/pnas.2113015118
      Issue No: Vol. 118, No. 42 (2021)
       
  • No evidence for colonization of oral bacteria in the distal gut in healthy
           adults [Microbiology]

    • Free pre-print version: Loading...

      Authors: Armin Rashidi; Maryam Ebadi, Daniel J. Weisdorf, Massimo Costalonga, Christopher Staley
      Abstract: The microbial communities in the mouth and colon are anatomically connected via the saliva. However, the extent to which oral microbes reach and successfully colonize the distal gut has been debated. To resolve this long-standing controversy, we used exact amplicon sequence variants generated from concurrently collected saliva/stool microbiota in 66...
      Keywords: Microbiology, Brief Reports
      PubDate: 2021-10-05T11:25:31-07:00
      DOI: 10.1073/pnas.2114152118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Correction for Oldenkamp et al., Filling the gaps in the global prevalence
           map of clinical antimicrobial resistance [Corrections]

    • Free pre-print version: Loading...

      Abstract: MICROBIOLOGY, SOCIAL SCIENCES Correction for “Filling the gaps in the global prevalence map of clinical antimicrobial resistance,” by Rik Oldenkamp, Constance Schultsz, Emiliano Mancini, and Antonio Cappuccio, which published December 28, 2020; 10.1073/pnas.2013515118 (Proc. Natl. Acad. Sci. U.S.A. 118, e2013515118). The authors note that on page 2, left column, first...
      Keywords: Corrections
      PubDate: 2021-10-04T12:00:46-07:00
      DOI: 10.1073/pnas.2116827118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Highly active engineered IgG3 antibodies against SARS-CoV-2 [Applied
           Biological Sciences]

    • Free pre-print version: Loading...

      Authors: Somanath Kallolimath; Lin Sun, Roman Palt, Karin Stiasny, Patrick Mayrhofer, Clemens Gruber, Benjamin Kogelmann, Qiang Chen, Herta Steinkellner
      Abstract: Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed at an unprecedented speed. Notwithstanding, there is a vague understanding of the various Ab functions induced beyond antigen binding by the heavy-chain constant domain. To explore the diverse roles of Abs in SARS-CoV-2 immunity, we expressed a SARS-CoV-2 spike protein...
      Keywords: Applied Biological Sciences, Brief Reports, Coronavirus (COVID-19)
      PubDate: 2021-10-01T11:27:16-07:00
      DOI: 10.1073/pnas.2107249118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition
           [Microbiology]

    • Free pre-print version: Loading...

      Authors: Xiaolei Liu; Anurag Verma, Gustavo Garcia Jr, Holly Ramage, Anastasia Lucas, Rebecca L. Myers, Jacob J. Michaelson, William Coryell, Arvind Kumar, Alexander W. Charney, Marcelo G. Kazanietz, Daniel J. Rader, Marylyn D. Ritchie, Wade H. Berrettini, David C. Schultz, Sara Cherry, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Peter S. Klein
      Abstract: The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections express a nucleocapsid protein (N) that is essential for viral replication, transcription, and virion assembly. Phosphorylation of N from SARS-CoV by glycogen synthase kinase 3 (GSK-3) is required for its function...
      Keywords: Microbiology, Coronavirus (COVID-19)
      PubDate: 2021-09-30T12:14:11-07:00
      DOI: 10.1073/pnas.2113401118
      Issue No: Vol. 118, No. 42 (2021)
       
  • Computational prediction of the effect of amino acid changes on the
           binding affinity between SARS-CoV-2 spike RBD and human ACE2 [Biophysics
           and Computational Biology]

    • Free pre-print version: Loading...

      Authors: Chen Chen; Veda Sheersh Boorla, Deepro Banerjee, Ratul Chowdhury, Victoria S. Cavener, Ruth H. Nissly, Abhinay Gontu, Nina R. Boyle, Kurt Vandegrift, Meera Surendran Nair, Suresh V. Kuchipudi, Costas D. Maranas
      Abstract: The association of the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with human angiotensin-converting enzyme 2 (hACE2) represents the first required step for cellular entry. SARS-CoV-2 has continued to evolve with the emergence of several novel variants, and amino acid changes in the...
      Keywords: Biophysics and Computational Biology, Coronavirus (COVID-19)
      PubDate: 2021-09-29T11:08:19-07:00
      DOI: 10.1073/pnas.2106480118
      Issue No: Vol. 118, No. 42 (2021)
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 35.175.107.77
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-