Journal Cover Nature Reviews Neuroscience
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   ISSN (Print) 1471-003X - ISSN (Online) 1471-0048
   Published by NPG Homepage  [135 journals]
  • Neuroimmunology: Brain police
    • Neuroimmunology: Brain police

      Neuroimmunology: Brain police, Published online: 19 January 2018; doi:10.1038/nrn.2018.5

      Microglial surveillance of the brain is dependent on maintenance of microglia membrane potential by the K+ channel THIK1, which is potentiated by ATP released at sites of tissue injury acting on P2Y12 receptors.Neuroimmunology: Brain police, Published online: 2018-01-19; doi:10.1038/nrn.2018.52018-01-19
      DOI: 10.1038/nrn.2018.5
       
  • Mitochondria at the neuronal presynapse in health and disease
    • Mitochondria at the neuronal presynapse in health and disease

      Mitochondria at the neuronal presynapse in health and disease, Published online: 19 January 2018; doi:10.1038/nrn.2017.170

      Mitochondria may be actively recruited to presynapses to supply energy, buffer calcium and, potentially, fulfil other functions. In this Review, Devine and Kittler examine the importance of this presynaptic population of mitochondria in the maintenance of neuronal homeostasis and how dysfunctional presynaptic mitochondria might contribute to neurodegenerative diseases.Mitochondria at the neuronal presynapse in health and disease, Published online: 2018-01-19; doi:10.1038/nrn.2017.1702018-01-19
      DOI: 10.1038/nrn.2017.170
       
  • Learning and memory: You only learn once
    • Learning and memory: You only learn once

      Learning and memory: You only learn once, Published online: 19 January 2018; doi:10.1038/nrn.2018.4

      When mice explore a new context, neurons in the locus coeruleus that project to hippocampal regions CA3 enable the learning of the new environment.Learning and memory: You only learn once, Published online: 2018-01-19; doi:10.1038/nrn.2018.42018-01-19
      DOI: 10.1038/nrn.2018.4
       
  • Neurodegenerative disease: A proteostatic boost
    • Neurodegenerative disease: A proteostatic boost

      Neurodegenerative disease: A proteostatic boost, Published online: 19 January 2018; doi:10.1038/nrn.2018.3

      Amyloid-β (Aβ)-induced proteotoxicity is linked to a mitochondrial stress response that may be conserved across species, and promoting mitochondrial proteostasis counteracts Aβ aggregation in worms and an Alzheimer disease mouse model.Neurodegenerative disease: A proteostatic boost, Published online: 2018-01-19; doi:10.1038/nrn.2018.32018-01-19
      DOI: 10.1038/nrn.2018.3
       
  • Leptin and the maintenance of elevated body weight
    • Leptin and the maintenance of elevated body weight

      Leptin and the maintenance of elevated body weight, Published online: 11 January 2018; doi:10.1038/nrn.2017.168

      Although leptin administration decreases food intake and body weight in lean mice, it has no effect in obese mice. In this Review, Pan and Myers discuss how leptin action becomes dysfunctional in obesity and suggest that elevated leptin levels promote processes that limit leptin action.Leptin and the maintenance of elevated body weight, Published online: 2018-01-11; doi:10.1038/nrn.2017.1682018-01-11
      DOI: 10.1038/nrn.2017.168
       
  • Dual function of thalamic low-vigilance state oscillations:
           rhythm-regulation and plasticity
    • Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity

      Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity, Published online: 11 January 2018; doi:10.1038/nrn.2017.151

      During low-vigilance states, thalamic neurons exhibit diverse rhythmic activities that contribute to specific parts of the electroencephalogram rhythm. In this perspective, Crunelli and colleagues propose that thalamic oscillations of these low-vigilance states also have a plasticity function that modifies the strength of excitatory and inhibitory synapses in local neuronal assemblies.Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity, Published online: 2018-01-11; doi:10.1038/nrn.2017.1512018-01-11
      DOI: 10.1038/nrn.2017.151
       
  • Intermittent metabolic switching, neuroplasticity and brain health
    • Intermittent metabolic switching, neuroplasticity and brain health

      Intermittent metabolic switching, neuroplasticity and brain health, Published online: 11 January 2018; doi:10.1038/nrn.2017.156

      Eating patterns in modern societies often preclude the metabolic switch from utilization of glucose to ketones as a cellular energy source. In this Review, Mattson and colleagues discuss how intermittent metabolic switching impacts brain function and vulnerability to injury and disease.Intermittent metabolic switching, neuroplasticity and brain health, Published online: 2018-01-11; doi:10.1038/nrn.2017.1562018-01-11
      DOI: 10.1038/nrn.2017.156
       
  • Neural coding: Investigating social spaces
    • Neural coding: Investigating social spaces

      Neural coding: Investigating social spaces, Published online: 21 December 2017; doi:10.1038/nrn.2017.169

      In mice, projections from the prelimbic cortex to the nucleus accumbens encode a combination of social and spatial information and may promote 'social investigation' behaviour by enabling social–spatial learning.Neural coding: Investigating social spaces, Published online: 2017-12-21; doi:10.1038/nrn.2017.1692017-12-21
      DOI: 10.1038/nrn.2017.169
       
 
 
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