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Journal Cover Nature Reviews Molecular Cell Biology
  [SJR: 32.928]   [H-I: 324]   [392 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1471-0072 - ISSN (Online) 1471-0080
   Published by NPG Homepage  [135 journals]
  • In the news: The Lasker goes to Michael Hall
    • In the news: The Lasker goes to Michael Hall

      Nature Reviews Molecular Cell Biology, Published online: 21 September 2017; doi:10.1038/nrm.2017.97

      The 2017 Albert Lasker Basic Medical Research Award was awarded to Michael N. Hall (Biozentrum, University of Basel, Switzerland) “for discoveries concerning the nutrient-activated TOR proteins and their central role in the metabolic control of cell growth”.

      Nature Reviews Molecular Cell Biology, Published online: 21 September 2017; doi:10.1038/nrm.2017.972017-09-21
      DOI: 10.1038/nrm.2017.97
       
  • Ubiquitylation at the crossroads of development and disease
    • Ubiquitylation at the crossroads of development and disease

      Nature Reviews Molecular Cell Biology, Published online: 20 September 2017; doi:10.1038/nrm.2017.83

      Ubiquitylation is a post-translational modification that modulates protein stability and regulates various cellular signalling pathways and cellular processes, including cell differentiation, proliferation and migration. Recent insights highlight its crucial role in development and how its deregulation is associated with several diseases.

      Nature Reviews Molecular Cell Biology, Published online: 20 September 2017; doi:10.1038/nrm.2017.832017-09-20
      DOI: 10.1038/nrm.2017.83
       
  • Nuclear Envelope: Chromosomes: one BAF layer to bind them all
    • Nuclear Envelope: Chromosomes: one BAF layer to bind them all

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.96

      Barrier-to-autointegration factor (BAF) forms a layer on the surface of chromatin at late mitosis, guiding the reformation of a single nuclear envelope surrounding all chromosomes.

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.962017-09-06
      DOI: 10.1038/nrm.2017.96
       
  • Fluorescence nanoscopy in cell biology
    • Fluorescence nanoscopy in cell biology

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.71

      Fluorescence nanoscopy enables the optical imaging of cellular components with resolutions at the nanometre scale. With the growing availability of super-resolution microscopes, nanoscopy methods are being increasingly applied. Quantitative, multicolour, live-cell nanoscopy and the corresponding labelling strategies are under continuous development.

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.712017-09-06
      DOI: 10.1038/nrm.2017.71
       
  • The emerging complexity of the tRNA world: mammalian tRNAs beyond protein
           synthesis
    • The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.77

      tRNAs exist as diverse species, including sequence isoforms and nuclease-generated fragments, which are further functionally diversified by base modifications and various protein interactions. Perhaps unsurprisingly, tRNAs are now being implicated in various cellular processes beyond protein synthesis per se, including in stress responses, proliferation, cell fate determination and tumorigenesis.

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.772017-09-06
      DOI: 10.1038/nrm.2017.77
       
  • Cell organization by liquid phase separation
    • Cell organization by liquid phase separation

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.93

      Daniel Gerlich discusses how a study by the Hyman laboratory introduced the theory of liquid phase separation to cell biology and its implications for the understanding of cell organization and function.

      Nature Reviews Molecular Cell Biology, Published online: 6 September 2017; doi:10.1038/nrm.2017.932017-09-06
      DOI: 10.1038/nrm.2017.93
       
  • Cytosolic lipolysis and lipophagy: two sides of the same coin
    • Cytosolic lipolysis and lipophagy: two sides of the same coin

      Nature Reviews Molecular Cell Biology, Published online: 30 August 2017; doi:10.1038/nrm.2017.76

      Lipolysis degrades triacylglycerols to supply cells with free fatty acids, which are essential components of membrane lipids and substrates for energy production. Recent discoveries transformed our understanding of the functions of and crosstalk between 'neutral' lipolysis, which occurs in the cytosol, and lipophagy and 'acid' lipolysis, which occur in lysosomes, and how dysfunction in these processes contributes to metabolic diseases.

      Nature Reviews Molecular Cell Biology, Published online: 30 August 2017; doi:10.1038/nrm.2017.762017-08-30
      DOI: 10.1038/nrm.2017.76
       
  • Regulation of heat shock transcription factors and their roles in
           physiology and disease
    • Regulation of heat shock transcription factors and their roles in physiology and disease

      Nature Reviews Molecular Cell Biology, Published online: 30 August 2017; doi:10.1038/nrm.2017.73

      Heat shock transcription factors (HSFs) regulate heat shock proteins in conditions of thermal stress, but they also control gene expression in other stress conditions, as well as in other contexts, including the regulation of cell proliferation and energy metabolism. HSFs are misregulated in various diseases, such as cancer and neurodegeneration, which underlines their important physiological roles.

      Nature Reviews Molecular Cell Biology, Published online: 30 August 2017; doi:10.1038/nrm.2017.732017-08-30
      DOI: 10.1038/nrm.2017.73
       
 
 
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