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Journal Cover Nature Reviews Immunology
  [SJR: 26.85]   [H-I: 292]   [202 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1474-1733 - ISSN (Online) 1474-1741
   Published by NPG Homepage  [135 journals]
  • The diverse functions of the PD1 inhibitory pathway
    • The diverse functions of the PD1 inhibitory pathway

      Nature Reviews Immunology, Published online: 9 October 2017; doi:10.1038/nri.2017.108

      In this Review, the authors detail the complex expression patterns and regulation of programmed cell death protein 1 (PD1) and its ligands. The authors focus on the importance of understanding these pathways in order to optimize the efficiency and safety of immune checkpoint blockade in patients.

      Nature Reviews Immunology, Published online: 9 October 2017; doi:10.1038/nri.2017.1082017-10-09
      DOI: 10.1038/nri.2017.108
       
  • Immune checkpoint blockade in infectious diseases
    • Immune checkpoint blockade in infectious diseases

      Nature Reviews Immunology, Published online: 9 October 2017; doi:10.1038/nri.2017.112

      Recent clinical trials have shown that blocking immune checkpoint molecules can boost antitumour immune responses. In this Review, the authors consider whether targeting these pathways could also be used to combat a range of infectious diseases, such as malaria, tuberculosis and chronic viral infections.

      Nature Reviews Immunology, Published online: 9 October 2017; doi:10.1038/nri.2017.1122017-10-09
      DOI: 10.1038/nri.2017.112
       
  • Neutrophil extracellular traps in immunity and disease
    • Neutrophil extracellular traps in immunity and disease

      Nature Reviews Immunology, Published online: 9 October 2017; doi:10.1038/nri.2017.105

      Neutrophil extracellular traps (NETs) protect against infection, but they are also implicated in the pathology associated with various immune-mediated conditions. This Review describes when and how they are formed, how they function and how they are regulated.

      Nature Reviews Immunology, Published online: 9 October 2017; doi:10.1038/nri.2017.1052017-10-09
      DOI: 10.1038/nri.2017.105
       
  • Regulation of immunity and inflammation by hypoxia in immunological niches
    • Regulation of immunity and inflammation by hypoxia in immunological niches

      Nature Reviews Immunology, Published online: 3 October 2017; doi:10.1038/nri.2017.103

      Hypoxia is a microenvironmental feature that is associated with physiological and pathological immunological niches. In this Review, Taylor and Colgan summarize the effects of physiological and pathological hypoxia on immune cells and processes and discuss the possibility of therapeutically targeting hypoxia-sensitive pathways.

      Nature Reviews Immunology, Published online: 3 October 2017; doi:10.1038/nri.2017.1032017-10-03
      DOI: 10.1038/nri.2017.103
       
  • Breastfeeding-related maternal microchimerism
    • Breastfeeding-related maternal microchimerism

      Nature Reviews Immunology, Published online: 3 October 2017; doi:10.1038/nri.2017.115

      Nature Reviews Immunology, Published online: 3 October 2017; doi:10.1038/nri.2017.1152017-10-03
      DOI: 10.1038/nri.2017.115
       
  • Reply: Breastfeeding-related maternal microchimerism
    • Reply: Breastfeeding-related maternal microchimerism

      Nature Reviews Immunology, Published online: 3 October 2017; doi:10.1038/nri.2017.117

      Nature Reviews Immunology, Published online: 3 October 2017; doi:10.1038/nri.2017.1172017-10-03
      DOI: 10.1038/nri.2017.117
       
  • Autoimmunity: LKB1 helps Treg cells battle exhaustion
    • Autoimmunity: LKB1 helps Treg cells battle exhaustion

      Nature Reviews Immunology, Published online: 27 September 2017; doi:10.1038/nri.2017.116

      LKB1 protects regulatory T cells from exhaustion, allowing them to efficiently control T helper 2 cell responses.

      Nature Reviews Immunology, Published online: 27 September 2017; doi:10.1038/nri.2017.1162017-09-27
      DOI: 10.1038/nri.2017.116
       
  • The spectrum of T cell metabolism in health and disease
    • The spectrum of T cell metabolism in health and disease

      Nature Reviews Immunology, Published online: 25 September 2017; doi:10.1038/nri.2017.99

      Here, the authors introduce the idea that a spectrum of metabolic states of immune cells can provide a basis for categorizing human diseases. They explore the metabolic and interlinked signalling requirements of T cells responding to acute infection and how metabolic reprogramming of T cells is linked to disease.

      Nature Reviews Immunology, Published online: 25 September 2017; doi:10.1038/nri.2017.992017-09-25
      DOI: 10.1038/nri.2017.99
       
 
 
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