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Nature Reviews Genetics
Journal Prestige (SJR): 34.896
Citation Impact (citeScore): 17
Number of Followers: 354  
  Full-text available via subscription Subscription journal
ISSN (Print) 1471-0056 - ISSN (Online) 1471-0064
Published by NPG Homepage  [138 journals]
  • A long read of the human genome
    • Nature Reviews Genetics, Published online: 03 August 2020; doi:10.1038/s41576-020-0273-5

      A study in Nature describes the assembly of a human genome with greater continuity than the current reference genome, as well as the assembly of a complete human X chromosome. These assemblies were achieved by combining data generated by different long-read sequencing technologies.Nature Reviews Genetics, Published online: 2020-08-03; doi:10.1038/s41576-020-0273-52020-08-03
      DOI: 10.1038/s41576-020-0273-5
  • mRNAs, proteins and the emerging principles of gene expression control
    • Nature Reviews Genetics, Published online: 24 July 2020; doi:10.1038/s41576-020-0258-4

      Gene expression is typically measured at the level of either mRNAs or proteins. In this Review, Buccitelli and Selbach discuss how large-scale comparative studies are characterizing the degree to which mRNA and protein levels correlate. They discuss technical and biological reasons why mRNA and protein levels may be particularly concordant or disconnected, as well as the different biological information provided by these non-redundant readouts of gene expression.Nature Reviews Genetics, Published online: 2020-07-24; doi:10.1038/s41576-020-0258-42020-07-24
      DOI: 10.1038/s41576-020-0258-4
  • Responsible, practical genomic data sharing that accelerates research
    • Nature Reviews Genetics, Published online: 21 July 2020; doi:10.1038/s41576-020-0257-5

      Data sharing can maximize the benefit and reach of genomics research. However, sharing must occur in a responsible manner, particularly when there are privacy risks to human participants. In this Review, the authors discuss the principles of data sharing, strategies for assessing and mitigating privacy risks, as well as practical guidelines for researchers and wider stakeholders.Nature Reviews Genetics, Published online: 2020-07-21; doi:10.1038/s41576-020-0257-52020-07-21
      DOI: 10.1038/s41576-020-0257-5
  • An odyssey to Oceania
    • Nature Reviews Genetics, Published online: 20 July 2020; doi:10.1038/s41576-020-0271-7

      A study in Nature analysing genome-wide variation in individuals from islands across Polynesia reports evidence of admixture with Native Americans related to Indigenous inhabitants of northern South America.Nature Reviews Genetics, Published online: 2020-07-20; doi:10.1038/s41576-020-0271-72020-07-20
      DOI: 10.1038/s41576-020-0271-7
  • From dog days to human years
    • Nature Reviews Genetics, Published online: 17 July 2020; doi:10.1038/s41576-020-0267-3

      Epigenetic clocks translate the DNA methylome into a biological age but usually work only within a species. Now, a study in Cell Systems reports a cross-species epigenetic clock that works across a number of mammals, including humans, dogs and mice.Nature Reviews Genetics, Published online: 2020-07-17; doi:10.1038/s41576-020-0267-32020-07-17
      DOI: 10.1038/s41576-020-0267-3
  • Redefining fundamental concepts of transcription initiation in bacteria
    • Nature Reviews Genetics, Published online: 14 July 2020; doi:10.1038/s41576-020-0254-8

      In this Expert Recommendation, the authors review the definitions of classic concepts relating to bacterial gene regulation, with a focus on transcription initiation, and suggest up-to-date, precise definitions to provide a reference for knowledge representation, modelling and future research on bacterial gene regulation.Nature Reviews Genetics, Published online: 2020-07-14; doi:10.1038/s41576-020-0254-82020-07-14
      DOI: 10.1038/s41576-020-0254-8
  • A zipcode for transcriptomes
    • Nature Reviews Genetics, Published online: 13 July 2020; doi:10.1038/s41576-020-0266-4

      A new study in Nature Methods presents the ‘ZipSeq’ spatial transcriptomics approach, whereby patterned illumination is used to print barcodes onto chosen tissue regions.Nature Reviews Genetics, Published online: 2020-07-13; doi:10.1038/s41576-020-0266-42020-07-13
      DOI: 10.1038/s41576-020-0266-4
  • Resolving the roles of structural variants
    • Nature Reviews Genetics, Published online: 07 July 2020; doi:10.1038/s41576-020-0264-6

      Structural variants have proved difficult to characterize using traditional sequencing approaches. In two new studies in Cell, the authors demonstrate the use of pan-genome approaches to identify and explore the impact of structural variants in crop genomes and reveal variants linked to specific agronomic traits.Nature Reviews Genetics, Published online: 2020-07-07; doi:10.1038/s41576-020-0264-62020-07-07
      DOI: 10.1038/s41576-020-0264-6
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