Journal Cover Nature Neuroscience
  [SJR: 13.558]   [H-I: 325]   [377 followers]  Follow
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   ISSN (Print) 1097-6256 - ISSN (Online) 1546-1726
   Published by NPG Homepage  [135 journals]
  • The Zika threat to the periphery
    • Authors: Themasap A. Khan, Sergiu P. Paşca
      Pages: 1191 - 1192
      Abstract: Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.
      Citation: Nature Neuroscience 20, 1191 (2017)
      PubDate: 2017-08-29
      DOI: 10.1038/nn.4633
      Issue No: Vol. 20, No. 9 (2017)
  • Loopholes in the DNA contract kill neurons
    • Authors: Karl Herrup, Kai-Hei Tse, Hei-Man Chow
      Pages: 1192 - 1194
      Abstract: Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.
      Citation: Nature Neuroscience 20, 1192 (2017)
      PubDate: 2017-08-29
      DOI: 10.1038/nn.4626
      Issue No: Vol. 20, No. 9 (2017)
  • Jamais vu all over again
    • Authors: Rebecca D Burwell, Victoria L Templer
      Pages: 1194 - 1196
      Abstract: What is the basis for the feeling that someplace or someone is familiar' Molas et al. have identified brain structures involved in signaling familiarity, a necessary element for the expression of preference for novelty.
      Citation: Nature Neuroscience 20, 1194 (2017)
      PubDate: 2017-08-29
      DOI: 10.1038/nn.4625
      Issue No: Vol. 20, No. 9 (2017)
  • Is population activity more than the sum of its parts'
    • Authors: Jonathan W Pillow, Mikio C Aoi
      Pages: 1196 - 1198
      Abstract: A study introduces innovative ways to test whether neural population activity exhibits structure above and beyond that of its basic components.
      Citation: Nature Neuroscience 20, 1196 (2017)
      PubDate: 2017-08-29
      DOI: 10.1038/nn.4627
      Issue No: Vol. 20, No. 9 (2017)
  • Functions and dysfunctions of neocortical inhibitory neuron subtypes
    • Authors: Ryoma Hattori, Kishore V Kuchibhotla, Robert C Froemke, Takaki Komiyama
      Pages: 1199 - 1208
      Abstract: Hattori et al. review the recent advances in our understanding of the roles of inhibitory neuron subtypes in shaping the activity and plasticity states of neocortical circuits, how neuromodulators control inhibitory neuron subtypes, and the role of inhibitory neuron dysfunction in neurological disorders.
      Citation: Nature Neuroscience 20, 1199 (2017)
      PubDate: 2017-08-29
      DOI: 10.1038/nn.4619
      Issue No: Vol. 20, No. 9 (2017)
  • Zika virus directly infects peripheral neurons and induces cell death
    • Authors: Yohan Oh, Feiran Zhang, Yaqing Wang, Emily M Lee, In Young Choi, Hotae Lim, Fahimeh Mirakhori, Ronghua Li, Luoxiu Huang, Tianlei Xu, Hao Wu, Cui Li, Cheng-Feng Qin, Zhexing Wen, Qing-Feng Wu, Hengli Tang, Zhiheng Xu, Peng Jin, Hongjun Song, Guo-li Ming, Gabsang Lee
      Pages: 1209 - 1212
      Abstract: Zika virus infection is associated with neurological disorders, yet few studies have directly examined its impact on the peripheral nervous system. Oh et al. show that Zika virus can infect peripheral neurons in the mouse in vivo, as well as human peripheral neurons in vitro, leading to increased cell death and transcriptional dysregulation.
      Citation: Nature Neuroscience 20, 1209 (2017)
      PubDate: 2017-07-31
      DOI: 10.1038/nn.4612
      Issue No: Vol. 20, No. 9 (2017)
  • Gut microbiota is critical for the induction of chemotherapy-induced pain
    • Authors: Shiqian Shen, Grewo Lim, Zerong You, Weihua Ding, Peigen Huang, Chongzhao Ran, Jason Doheny, Peter Caravan, Samuel Tate, Kun Hu, Hyangin Kim, Michael McCabe, Bo Huang, Zhongcong Xie, Douglas Kwon, Lucy Chen, Jianren Mao
      Pages: 1213 - 1216
      Abstract: Recent evidence supports a functional connection between gut microbiota and the nervous system. Here the authors show that gut microbiota plays a critical role in the development of chemotherapy-induced pain. This role of the microbiota is likely mediated, in part, by Tlr4 expressed on hematopoietic cells, including macrophages.
      Citation: Nature Neuroscience 20, 1213 (2017)
      PubDate: 2017-07-17
      DOI: 10.1038/nn.4606
      Issue No: Vol. 20, No. 9 (2017)
  • Rates, distribution and implications of postzygotic mosaic mutations in
           autism spectrum disorder
    • Authors: Elaine T Lim, Mohammed Uddin, Silvia De Rubeis, Yingleong Chan, Anne S Kamumbu, Xiaochang Zhang, Alissa M D'Gama, Sonia N Kim, Robert Sean Hill, Arthur P Goldberg, Christopher Poultney, Nancy J Minshew, Itaru Kushima, Branko Aleksic, Norio Ozaki, Mara Parellada, Celso Arango, Maria J Penzol, Angel Carracedo, Alexander Kolevzon, Christina M Hultman, Lauren A Weiss, Menachem Fromer, Andreas G Chiocchetti, Christine M Freitag, George M Church, Stephen W Scherer, Joseph D Buxbaum, Christopher A Walsh
      Pages: 1217 - 1224
      Abstract: Survey of postzygotic mosaic mutations (PZMs) in 5,947 trios with autism spectrum disorders (ASD) discovers differences in mutational properties between germline mutations and PZMs. Spatiotemporal analyses of the PZMs also revealed the association of the amygdala with ASD and implicated risk genes, including recurrent potential gain-of-function mutations in SMARCA4.
      Citation: Nature Neuroscience 20, 1217 (2017)
      PubDate: 2017-07-17
      DOI: 10.1038/nn.4598
      Issue No: Vol. 20, No. 9 (2017)
  • C9orf72 expansion disrupts ATM-mediated chromosomal break repair
    • Authors: Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed, Vera Lukashchuk, Shih-Chieh Chiang, Swagat Ray, Padraig J Mulcahy, Mateusz Jurga, Ioannis Tsagakis, Tommaso Iannitti, Jayanth Chandran, Ian Coldicott, Kurt J De Vos, Mohamed K Hassan, Adrian Higginbottom, Pamela J Shaw, Guillaume M Hautbergue, Mimoun Azzouz, Sherif F El-Khamisy
      Pages: 1225 - 1235
      Abstract: An expanded repetition of a DNA sequence within the C9orf72 gene is the most common genetic cause for motor neuron disease and frontotemporal dementia. In this study, the authors show that this expansion causes increased genomic breaks and reduces the cell's ability to repair the breaks, ultimately leading to neuronal cell death.
      Citation: Nature Neuroscience 20, 1225 (2017)
      PubDate: 2017-07-17
      DOI: 10.1038/nn.4604
      Issue No: Vol. 20, No. 9 (2017)
  • Necroptosis activation in Alzheimer's disease
    • Authors: Antonella Caccamo, Caterina Branca, Ignazio S Piras, Eric Ferreira, Matthew J Huentelman, Winnie S Liang, Ben Readhead, Joel T Dudley, Elizabeth E Spangenberg, Kim N Green, Ramona Belfiore, Wendy Winslow, Salvatore Oddo
      Pages: 1236 - 1246
      Abstract: The mechanisms underpinning neuronal death in Alzheimer's disease (AD) remain unclear. Caccamo and colleagues show that necroptosis contributes to neurodegeneration in AD. Blocking necroptosis reduced neuronal loss in a mouse model of AD, suggesting that necroptosis might be a therapeutic target in AD.
      Citation: Nature Neuroscience 20, 1236 (2017)
      PubDate: 2017-07-24
      DOI: 10.1038/nn.4608
      Issue No: Vol. 20, No. 9 (2017)
  • Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and
           cognitive side effects
    • Authors: Daisuke Ibi, Mario de la Fuente Revenga, Nebojsa Kezunovic, Carolina Muguruza, Justin M Saunders, Supriya A Gaitonde, José L Moreno, Maryum K Ijaz, Vishaka Santosh, Alexey Kozlenkov, Terrell Holloway, Jeremy Seto, Aintzane García-Bea, Mitsumasa Kurita, Grace E Mosley, Yan Jiang, Daniel J Christoffel, Luis F Callado, Scott J Russo, Stella Dracheva, Juan F López-Giménez, Yongchao Ge, Carlos R Escalante, J Javier Meana, Schahram Akbarian, George W Huntley, Javier González-Maeso
      Pages: 1247 - 1259
      Abstract: Antipsychotic treatment in patients with schizophrenia often reduces hallucinations and delusions, but cognitive deficits that impair performance of everyday activities may persist or worsen. Our findings reveal a mechanism by which increased NF-κB activity leads to increased HDAC2 levels, impairing synaptic plasticity and memory during prolonged antipsychotic treatment.
      Citation: Nature Neuroscience 20, 1247 (2017)
      PubDate: 2017-08-07
      DOI: 10.1038/nn.4616
      Issue No: Vol. 20, No. 9 (2017)
  • A circuit-based mechanism underlying familiarity signaling and the
           preference for novelty
    • Authors: Susanna Molas, Rubing Zhao-Shea, Liwang Liu, Steven R DeGroot, Paul D Gardner, Andrew R Tapper
      Pages: 1260 - 1268
      Abstract: The mechanistic basis of how novel stimuli become familiar with repeated exposures has remained elusive. Molas et al. demonstrate that familiarity activates the interpeduncular nucleus, thereby reducing motivation to explore. Familiarity signaling in the interpeduncular nucleus is bidirectionally modulated by habenula and ventral tegmental area afferents to control novelty preference.
      Citation: Nature Neuroscience 20, 1260 (2017)
      PubDate: 2017-07-17
      DOI: 10.1038/nn.4607
      Issue No: Vol. 20, No. 9 (2017)
  • Dorsal hippocampus contributes to model-based planning
    • Authors: Kevin J Miller, Matthew M Botvinick, Carlos D Brody
      Pages: 1269 - 1276
      Abstract: Although the hippocampus has long been linked to planning, it has not been shown to be necessary for planning behavior. Using computational modeling and a new rat task that allows the quantification of planning behavior across many repeated trials, the authors report the first evidence that hippocampal inactivation impairs planning.
      Citation: Nature Neuroscience 20, 1269 (2017)
      PubDate: 2017-07-31
      DOI: 10.1038/nn.4613
      Issue No: Vol. 20, No. 9 (2017)
  • Neural reactivations during sleep determine network credit assignment
    • Authors: Tanuj Gulati, Ling Guo, Dhakshin S Ramanathan, Anitha Bodepudi, Karunesh Ganguly
      Pages: 1277 - 1284
      Abstract: A fundamental goal of learning is to establish neural patterns that cause desired behaviors. This paper demonstrates that sleep-dependent processing is required for credit assignment and the establishment of task-related activity reflecting the causal neuron-behavior relationship. Decoupling of spiking to sleep slow oscillations using optogenetics methods disrupted this process.
      Citation: Nature Neuroscience 20, 1277 (2017)
      PubDate: 2017-07-10
      DOI: 10.1038/nn.4601
      Issue No: Vol. 20, No. 9 (2017)
  • Functional dissection of signal and noise in MT and LIP during
    • Authors: Jacob L Yates, Il Memming Park, Leor N Katz, Jonathan W Pillow, Alexander C Huk
      Pages: 1285 - 1292
      Abstract: Yates and colleagues statistically dissect MT and LIP responses during motion discrimination. They show decreasing temporal weighting of motion in MT, consistent with psychophysical weighting, and show that LIP spikes encode the upcoming choice more than integrated motion or simultaneously recorded MT spikes, suggesting an indirect relationship between these areas.
      Citation: Nature Neuroscience 20, 1285 (2017)
      PubDate: 2017-07-24
      DOI: 10.1038/nn.4611
      Issue No: Vol. 20, No. 9 (2017)
  • Adults with autism overestimate the volatility of the sensory environment
    • Authors: Rebecca P Lawson, Christoph Mathys, Geraint Rees
      Pages: 1293 - 1299
      Abstract: The authors address why the use of prior expectations might be compromised in autism, by using computational models and pupillometric markers of the neuromodulator noradrenaline. They show that by estimating the world to be more changeable than it really is, adults with autism have difficulty in learning what to expect.
      Citation: Nature Neuroscience 20, 1293 (2017)
      PubDate: 2017-07-31
      DOI: 10.1038/nn.4615
      Issue No: Vol. 20, No. 9 (2017)
  • High-dimensional, single-cell characterization of the brain's immune
    • Authors: Ben Korin, Tamar L Ben-Shaanan, Maya Schiller, Tania Dubovik, Hilla Azulay-Debby, Nadia T Boshnak, Tamar Koren, Asya Rolls
      Pages: 1300 - 1309
      Abstract: Korin et al. use CyTOF mass cytometry to characterize immune cell populations in the naive mouse brain (parenchyma, choroid plexus and meninges). This single-cell analysis of cell-surface proteins reveals the presence and phenotype of distinctive immune populations in the mouse brain compartment.
      Citation: Nature Neuroscience 20, 1300 (2017)
      PubDate: 2017-07-24
      DOI: 10.1038/nn.4610
      Issue No: Vol. 20, No. 9 (2017)
  • Structure in neural population recordings: an expected byproduct of
           simpler phenomena'
    • Authors: Gamaleldin F Elsayed, John P Cunningham
      Pages: 1310 - 1318
      Abstract: To what extent are population-level results an expected byproduct of simpler structure already known to exist in single neurons' Conventional controls are insufficient to perform this critical investigation. The authors developed a methodological framework to test the significance of population-level studies and apply it to prefrontal and motor cortices.
      Citation: Nature Neuroscience 20, 1310 (2017)
      PubDate: 2017-08-07
      DOI: 10.1038/nn.4617
      Issue No: Vol. 20, No. 9 (2017)
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