Journal Cover Nature Neuroscience
  [SJR: 13.558]   [H-I: 325]   [390 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1097-6256 - ISSN (Online) 1546-1726
   Published by NPG Homepage  [135 journals]
  • Grid scale drives the scale and long-term stability of place maps
    • Grid scale drives the scale and long-term stability of place maps

      Grid scale drives the scale and long-term stability of place maps, Published online: 15 January 2018; doi:10.1038/s41593-017-0055-3

      How entorhinal grid cells control hippocampal coding and behavior remains elusive. The authors report that increasing the spatial scale of grid cells expands the scale and reduces the stability of place fields, impairing spatial memory in mice.Grid scale drives the scale and long-term stability of place maps, Published online: 2018-01-15; doi:10.1038/s41593-017-0055-32018-01-15
      DOI: 10.1038/s41593-017-0055-3
       
  • In vivo simultaneous transcriptional activation of multiple genes in the
           brain using CRISPR–dCas9-activator transgenic mice
    • In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice

      In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice, Published online: 15 January 2018; doi:10.1038/s41593-017-0060-6

      dCas9-mediated activation has been verified and widely used in vitro. Here the authors generated a potent in vivo activation platform and applied it to control the transcription of multiple genetic elements in the mammalian brain.In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice, Published online: 2018-01-15; doi:10.1038/s41593-017-0060-62018-01-15
      DOI: 10.1038/s41593-017-0060-6
       
  • Conserved properties of dentate gyrus neurogenesis across postnatal
           development revealed by single-cell RNA sequencing
    • Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

      Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing, Published online: 15 January 2018; doi:10.1038/s41593-017-0056-2

      Using single-cell RNA-seq, the authors show that early developmental neurogenesis in the dentate gyrus of the hippocampus is largely conserved in the adult, but with a perinatal transformation of stem cells to an adult type.Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing, Published online: 2018-01-15; doi:10.1038/s41593-017-0056-22018-01-15
      DOI: 10.1038/s41593-017-0056-2
       
  • Dietary salt promotes neurovascular and cognitive dysfunction through a
           gut-initiated TH17 response
    • Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

      Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response, Published online: 15 January 2018; doi:10.1038/s41593-017-0059-z

      A salt-rich diet promotes cerebrovascular diseases and dementia. This study shows that high dietary salt in mice induces a TH17 response in the gut leading to cerebral endothelial dysfunction and cognitive impairment via circulating IL-17.Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response, Published online: 2018-01-15; doi:10.1038/s41593-017-0059-z2018-01-15
      DOI: 10.1038/s41593-017-0059-z
       
  • Dentate network activity is necessary for spatial working memory by
           supporting CA3 sharp-wave ripple generation and prospective firing of CA3
           neurons
    • Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons

      Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons, Published online: 15 January 2018; doi:10.1038/s41593-017-0061-5

      Sasaki et al. reveal that the dentate gyrus not only performs pattern separation but also has a direct role in organizing memory-guided behavior by coordinating the planning of future actions.Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons, Published online: 2018-01-15; doi:10.1038/s41593-017-0061-52018-01-15
      DOI: 10.1038/s41593-017-0061-5
       
  • N 6-methyladenosine RNA modification regulates embryonic neural stem cell
           self-renewal through histone modifications
    • N 6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

      N 6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications, Published online: 15 January 2018; doi:10.1038/s41593-017-0057-1

      Using a genetic approach, Wang et al. demonstrate an essential function for m6A mRNA modification in promoting neural stem cell proliferation and reveal interactions between m6A and histone modification as a novel gene regulatory mechanism. N 6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications, Published online: 2018-01-15; doi:10.1038/s41593-017-0057-12018-01-15
      DOI: 10.1038/s41593-017-0057-1
       
  • Hexadirectional coding of visual space in human entorhinal cortex
    • Hexadirectional coding of visual space in human entorhinal cortex

      Hexadirectional coding of visual space in human entorhinal cortex, Published online: 08 January 2018; doi:10.1038/s41593-017-0050-8

      fMRI activity in human entorhinal cortex is modulated by eye-movement direction with 60° periodicity, implicating a grid cell-like code in mapping visual space. This suggests a role for entorhinal grid coding in cognition beyond spatial navigation.Hexadirectional coding of visual space in human entorhinal cortex, Published online: 2018-01-08; doi:10.1038/s41593-017-0050-82018-01-08
      DOI: 10.1038/s41593-017-0050-8
       
  • Simple integration of fast excitation and offset, delayed inhibition
           computes directional selectivity in Drosophila
    • Simple integration of fast excitation and offset, delayed inhibition computes directional selectivity in Drosophila

      Simple integration of fast excitation and offset, delayed inhibition computes directional selectivity in Drosophila , Published online: 08 January 2018; doi:10.1038/s41593-017-0046-4

      In the Drosophila visual system, T4 is the first cell type in the ON pathway to exhibit directionally selective signals. This directional selectivity originates from simple integration of spatially offset fast excitatory and slow inhibitory inputs.Simple integration of fast excitation and offset, delayed inhibition computes directional selectivity in Drosophila , Published online: 2018-01-08; doi:10.1038/s41593-017-0046-42018-01-08
      DOI: 10.1038/s41593-017-0046-4
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016