Journal Cover Nature Neuroscience
  [SJR: 13.558]   [H-I: 325]   [369 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1097-6256 - ISSN (Online) 1546-1726
   Published by NPG Homepage  [135 journals]
  • A multiregional proteomic survey of the postnatal human brain
    • A multiregional proteomic survey of the postnatal human brain

      A multiregional proteomic survey of the postnatal human brain, Published online: 13 November 2017; doi:10.1038/s41593-017-0011-2

      NatureArticleSnippet(type=short-summary, markup=

      Quantitative mass spectrometry was used to produce a proteomic survey of postnatal human brain regions. Compared to matched RNA-seq, protein levels showed more regional variation, especially for membrane-associated proteins in the neocortex.

      , isJats=true)A multiregional proteomic survey of the postnatal human brain, Published online: 2017-11-13; doi:10.1038/s41593-017-0011-22017-11-13
      DOI: 10.1038/s41593-017-0011-2
       
  • Lateral geniculate neurons projecting to primary visual cortex show ocular
           dominance plasticity in adult mice
    • Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice

      Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice, Published online: 13 November 2017; doi:10.1038/s41593-017-0021-0

      NatureArticleSnippet(type=short-summary, markup=

      Experience-dependent plasticity in the visual system has widely been considered to be exclusively cortical. Using chronic two-photon Ca2+imaging of individual thalamic boutons, Jaepel et al. now report that dLGN cells projecting to mouse visual cortex show pronounced ocular dominance plasticity after monocular deprivation.

      , isJats=true)Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice, Published online: 2017-11-13; doi:10.1038/s41593-017-0021-02017-11-13
      DOI: 10.1038/s41593-017-0021-0
       
  • Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate
           fluid intake
    • Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake

      Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake, Published online: 13 November 2017; doi:10.1038/s41593-017-0014-z

      NatureArticleSnippet(type=short-summary, markup=

      The authors show that oxytocin-receptor-expressing neurons in the parabrachial nucleus are key regulators of fluid homeostasis that suppress fluid intake when activated, but do not decrease food intake after fasting or salt intake after salt depletion.

      , isJats=true)Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake, Published online: 2017-11-13; doi:10.1038/s41593-017-0014-z2017-11-13
      DOI: 10.1038/s41593-017-0014-z
       
  • A craniofacial-specific monosynaptic circuit enables heightened affective
           pain
    • A craniofacial-specific monosynaptic circuit enables heightened affective pain

      A craniofacial-specific monosynaptic circuit enables heightened affective pain, Published online: 13 November 2017; doi:10.1038/s41593-017-0012-1

      NatureArticleSnippet(type=short-summary, markup=

      The authors show that unlike body sensory neurons, craniofacial nociceptive neurons directly synapse with noxious-stimulus-activated lateral parabrachial neurons (PBL), which in turn project to multiple limbic centers processing emotions and affects. This monosynaptic pathway is both sufficient and necessary for craniofacial-pain-activated aversive behaviors.

      , isJats=true)A craniofacial-specific monosynaptic circuit enables heightened affective pain, Published online: 2017-11-13; doi:10.1038/s41593-017-0012-12017-11-13
      DOI: 10.1038/s41593-017-0012-1
       
  • Temporally precise single-cell-resolution optogenetics
    • Temporally precise single-cell-resolution optogenetics

      Temporally precise single-cell-resolution optogenetics, Published online: 13 November 2017; doi:10.1038/s41593-017-0018-8

      NatureArticleSnippet(type=short-summary, markup=

      The authors develop a methods suite for millisecond-precise, single-cell-resolution control of neural activity through protein engineering of novel opsin/trafficking sequence combinations, as well as optimized holographic two-photon optics.

      , isJats=true)Temporally precise single-cell-resolution optogenetics, Published online: 2017-11-13; doi:10.1038/s41593-017-0018-82017-11-13
      DOI: 10.1038/s41593-017-0018-8
       
  • Social stress induces neurovascular pathology promoting depression
    • Social stress induces neurovascular pathology promoting depression

      Social stress induces neurovascular pathology promoting depression, Published online: 13 November 2017; doi:10.1038/s41593-017-0010-3

      NatureArticleSnippet(type=short-summary, markup=

      Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors.

      , isJats=true)Social stress induces neurovascular pathology promoting depression, Published online: 2017-11-13; doi:10.1038/s41593-017-0010-32017-11-13
      DOI: 10.1038/s41593-017-0010-3
       
  • Weak correlations between hemodynamic signals and ongoing neural activity
           during the resting state
    • Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

      Weak correlations between hemodynamic signals and ongoing neural activity during the resting state, Published online: 06 November 2017; doi:10.1038/s41593-017-0007-y

      NatureArticleSnippet(type=short-summary, markup=

      The relationship of resting-state hemodynamics signals to ongoing neural activity is poorly understood. Using optical imaging, electrophysiology, and local pharmacological infusions, Winder et al. found that resting hemodynamic signals were weakly correlated with neural activity and that these hemodynamic fluctuations persisted when neural activity was silenced.

      , isJats=true)Weak correlations between hemodynamic signals and ongoing neural activity during the resting state, Published online: 2017-11-06; doi:10.1038/s41593-017-0007-y2017-11-06
      DOI: 10.1038/s41593-017-0007-y
       
  • Arid1b haploinsufficiency disrupts cortical interneuron development
           and mouse behavior
    • Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior

      Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior, Published online: 06 November 2017; doi:10.1038/s41593-017-0013-0

      NatureArticleSnippet(type=short-summary, markup=

      Arid1b haploinsufficiency causes autism and intellectual disability, yet the neurobiological basis of this is unknown. The authors demonstrate that Arid1b-heterozygous mice have impaired cortical interneuron development and epigenetic signatures. These mice also have cognitive and social deficits, which are reversed by treatment with a GABAA-receptor-positive allosteric modulator.

      , isJats=true) Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior, Published online: 2017-11-06; doi:10.1038/s41593-017-0013-02017-11-06
      DOI: 10.1038/s41593-017-0013-0
       
 
 
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