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Journal Cover Nature Medicine
  [SJR: 13.959]   [H-I: 439]   [675 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 1078-8956 - ISSN (Online) 1546-170X
   Published by NPG Homepage  [135 journals]
  • Children first
    • Pages: 1005 - 1005
      Abstract: Drugs administered to children with cancer were typically developed under the assumption that childhood cancers are similar to their tissue-matched adult counterparts. Focusing on identifying and targeting alterations present specifically in childhood tumors will accelerate the development of tailored therapies and improve the prognosis of children with cancer.
      Citation: Nature Medicine 23, 1005 (2017)
      PubDate: 2017-09-08
      DOI: 10.1038/nm.4404
      Issue No: Vol. 23, No. 9 (2017)
  • Uncovering cancer: How enlisting T cells can boost the power of
    • Nature Medicine 23, 1006 (2017). doi:10.1038/nm0917-1006

      Author: Amanda B. Keener

      Nature Medicine 23, 1006 (2017)2017-09-08
      DOI: 10.1038/nm0917-1006
      Issue No: Vol. 23, No. 9 (2017)
  • Inflammatory illness: Why the next wave of antidepressants may target the
           immune system
    • Nature Medicine 23, 1009 (2017). doi:10.1038/nm0917-1009

      Author: Nicole Wetsman

      Nature Medicine 23, 1009 (2017)2017-09-08
      DOI: 10.1038/nm0917-1009
      Issue No: Vol. 23, No. 9 (2017)
  • Correction
    • Nature Medicine 23, 1011 (2017). doi:10.1038/nm0917-1011

      Nature Medicine 23, 1011 (2017)2017-09-08
      DOI: 10.1038/nm0917-1011
      Issue No: Vol. 23, No. 9 (2017)
  • The enteric virome in hematopoietic stem cell transplantation: ready for
           its close-up
    • Authors: Shuichiro Takashima, Alan M Hanash
      Pages: 1012 - 1013
      Abstract: A new study highlights dynamic changes in the enteric virome after hematopoietic stem cell transplantation in humans, pointing to a correlation between these changes and graft-versus-host disease.
      Citation: Nature Medicine 23, 1012 (2017)
      PubDate: 2017-09-08
      DOI: 10.1038/nm.4403
      Issue No: Vol. 23, No. 9 (2017)
  • SPOP tips the balance of BETs in cancer
    • Authors: Katie A Fennell, Mark A Dawson
      Pages: 1014 - 1015
      Abstract: Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.
      Citation: Nature Medicine 23, 1014 (2017)
      PubDate: 2017-09-08
      DOI: 10.1038/nm.4398
      Issue No: Vol. 23, No. 9 (2017)
  • Sex-specific disease-associated modules for depression
    • Authors: Ronald S Duman
      Pages: 1015 - 1017
      Abstract: A recent study reveals sexually dimorphic disease-associated gene-expression modules and hub genes in postmortem brains from female and male individuals with depression. These modules are conserved in mouse models of depression.
      Citation: Nature Medicine 23, 1015 (2017)
      PubDate: 2017-09-08
      DOI: 10.1038/nm.4391
      Issue No: Vol. 23, No. 9 (2017)
  • Microglia emerge as central players in brain disease
    • Authors: Michael W Salter, Beth Stevens
      Pages: 1018 - 1027
      Abstract: In this Review, Salter and Stevens discuss the role of microglia in CNS disorders such as autism, neurodegenerative disorders, Alzheimer’s disease, and chronic pain.
      Citation: Nature Medicine 23, 1018 (2017)
      PubDate: 2017-09-08
      DOI: 10.1038/nm.4397
      Issue No: Vol. 23, No. 9 (2017)
  • Functional precision cancer medicine—moving beyond pure genomics
    • Authors: Anthony Letai
      Pages: 1028 - 1035
      Abstract: Anthony Letai proposes wider adoption of functional assays in efforts to match the right drug to the right patient and discusses why these assays might be complementary to existing genomics-based approaches.
      Citation: Nature Medicine 23, 1028 (2017)
      PubDate: 2017-09-08
      DOI: 10.1038/nm.4389
      Issue No: Vol. 23, No. 9 (2017)
  • D-mannose induces regulatory T cells and suppresses immunopathology
    • Authors: Dunfang Zhang, Cheryl Chia, Xue Jiao, Wenwen Jin, Shimpei Kasagi, Ruiqing Wu, Joanne E Konkel, Hiroko Nakatsukasa, Peter Zanvit, Nathan Goldberg, Qianming Chen, Lingyun Sun, Zi-Jiang Chen, WanJun Chen
      Pages: 1036 - 1045
      Abstract: D-mannose promotes Treg cell differentiation and is therapeutic in mouse models of autoimmune diabetes and airway inflammation.
      Citation: Nature Medicine 23, 1036 (2017)
      PubDate: 2017-07-24
      DOI: 10.1038/nm.4375
      Issue No: Vol. 23, No. 9 (2017)
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein
           degradation and sensitivity to BET inhibitors
    • Authors: Hana Janouskova, Geniver El Tekle, Elisa Bellini, Namrata D Udeshi, Anna Rinaldi, Anna Ulbricht, Tiziano Bernasocchi, Gianluca Civenni, Marco Losa, Tanya Svinkina, Craig M Bielski, Gregory V Kryukov, Luciano Cascione, Sara Napoli, Radoslav I Enchev, David G Mutch, Michael E Carney, Andrew Berchuck, Boris J N Winterhoff, Russell R Broaddus, Peter Schraml, Holger Moch, Francesco Bertoni, Carlo V Catapano, Matthias Peter, Steven A Carr, Levi A Garraway, Peter J Wild, Jean-Philippe P Theurillat
      Pages: 1046 - 1054
      Abstract: Different mutations found in endometrial and prostate tumors affecting the substrate-recognition domain of SPOP, a component of the E3 ubiquitin ligase complex, result in opposing degradation activity of BET proteins and response to BET inhibitors. This work, along with findings by Zhang et al. and Dai et al., highlights the divergent effects of recurrent mutations affecting different residues within the same functional domain of SPOP and provides scientific rationale to guide the administration of BET inhibitors in endometrial and prostate cancer patients harboring SPOP mutations.
      Citation: Nature Medicine 23, 1046 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nm.4372
      Issue No: Vol. 23, No. 9 (2017)
  • Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is
           mediated by BET protein stabilization and AKT–mTORC1 activation
    • Authors: Pingzhao Zhang, Dejie Wang, Yu Zhao, Shancheng Ren, Kun Gao, Zhenqing Ye, Shangqian Wang, Chun-Wu Pan, Yasheng Zhu, Yuqian Yan, Yinhui Yang, Di Wu, Yundong He, Jun Zhang, Daru Lu, Xiuping Liu, Long Yu, Shimin Zhao, Yao Li, Dong Lin, Yuzhuo Wang, Liguo Wang, Yu Chen, Yinghao Sun, Chenji Wang, Haojie Huang
      Pages: 1055 - 1062
      Abstract: Mutations in SPOP, the gene encoding a component of the E3 ubiquitin ligase complex, impair ubiquitination-dependent degradation of BRD2, BRD3 and BRD4 proteins and result in activation of ATK–mTORC1 signaling and resistance to BET inhibitors. Pharmacological blockade of AKT represents a viable strategy to restore the sensitivity of SPOP-mutant prostate tumors to BET inhibitors. These results, together with findings by Dai et al. and Janouskova et al., uncover a new nongenetic mechanism of resistance to BET inhibition involving cancer-type-specific mutations in SPOP, and support the evaluation of SPOP mutation status to inform the administration of BET inhibitors in the clinic.
      Citation: Nature Medicine 23, 1055 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nm.4379
      Issue No: Vol. 23, No. 9 (2017)
  • Prostate cancer–associated SPOP mutations confer resistance to BET
           inhibitors through stabilization of BRD4
    • Authors: Xiangpeng Dai, Wenjian Gan, Xiaoning Li, Shangqian Wang, Wei Zhang, Ling Huang, Shengwu Liu, Qing Zhong, Jianping Guo, Jinfang Zhang, Ting Chen, Kouhei Shimizu, Francisco Beca, Mirjam Blattner, Divya Vasudevan, Dennis L Buckley, Jun Qi, Lorenz Buser, Pengda Liu, Hiroyuki Inuzuka, Andrew H Beck, Liewei Wang, Peter J Wild, Levi A Garraway, Mark A Rubin, Christopher E Barbieri, Kwok-Kin Wong, Senthil K Muthuswamy, Jiaoti Huang, Yu Chen, James E Bradner, Wenyi Wei
      Pages: 1063 - 1071
      Abstract: Recurrent mutations in SPOP-encoding a Cullin 3-based E3 ubiquitin ligase- in prostate cancer disrupt the recognition and degradation of ubiquitination substrates, including BET proteins. Consequently, stability of BET proteins is enhanced and this increases the resistance to BET inhibitors in SPOP-mutant prostate tumors. These results, together with those in Janouskova et al. and Zhang et al., uncover a novel non genetic mechanism of resistance to BET inhibition involving cancer type-specific mutations in SPOP, and support the evaluation of SPOP mutations to inform the administration of BET inhibitors in the clinic.
      Citation: Nature Medicine 23, 1063 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/nm.4378
      Issue No: Vol. 23, No. 9 (2017)
  • Targeting cellular senescence prevents age-related bone loss in mice
    • Authors: Joshua N Farr, Ming Xu, Megan M Weivoda, David G Monroe, Daniel G Fraser, Jennifer L Onken, Brittany A Negley, Jad G Sfeir, Mikolaj B Ogrodnik, Christine M Hachfeld, Nathan K LeBrasseur, Matthew T Drake, Robert J Pignolo, Tamar Pirtskhalava, Tamara Tchkonia, Merry Jo Oursler, James L Kirkland, Sundeep Khosla
      Pages: 1072 - 1079
      Abstract: Genetic or pharmacological depletion of senescent cells or inhibition of their function reduces bone loss in aged mice.
      Citation: Nature Medicine 23, 1072 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/nm.4385
      Issue No: Vol. 23, No. 9 (2017)
  • The eukaryotic gut virome in hematopoietic stem cell transplantation: new
           clues in enteric graft-versus-host disease
    • Authors: Jérôme Legoff, Matthieu Resche-Rigon, Jerome Bouquet, Marie Robin, Samia N Naccache, Séverine Mercier-Delarue, Scot Federman, Erik Samayoa, Clotilde Rousseau, Prescillia Piron, Nathalie Kapel, François Simon, Gérard Socié, Charles Y Chiu
      Pages: 1080 - 1085
      Abstract: Charles Chiu and colleagues analyze the gut viromes of recipients of hematopoietic stem cell transplantation and identify characteristics associated with the severity of graft-versus-host disease in the gut.
      Citation: Nature Medicine 23, 1080 (2017)
      PubDate: 2017-07-31
      DOI: 10.1038/nm.4380
      Issue No: Vol. 23, No. 9 (2017)
  • A human APOC3 missense variant and monoclonal antibody accelerate apoC-III
           clearance and lower triglyceride-rich lipoprotein levels
    • Authors: Sumeet A Khetarpal, Xuemei Zeng, John S Millar, Cecilia Vitali, Amritha Varshini Hanasoge Somasundara, Paolo Zanoni, James A Landro, Nicole Barucci, William J Zavadoski, Zhiyuan Sun, Hans de Haard, Ildikó V Toth, Gina M Peloso, Pradeep Natarajan, Marina Cuchel, Sissel Lund-Katz, Michael C Phillips, Alan R Tall, Sekar Kathiresan, Paul DaSilva-Jardine, Nathan A Yates, Daniel J Rader
      Pages: 1086 - 1094
      Abstract: On the basis of new mechanistic studies of a mutant form of the apolipoprotein apoC-III that protects against coronary heart disease, Khetarpal et al. have developed therapeutic apoC-III-targeting monoclonal antibodies that lower circulating apoC-III protein and triglyceride levels in mice.
      Citation: Nature Medicine 23, 1086 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/nm.4390
      Issue No: Vol. 23, No. 9 (2017)
  • Implications of human genetic variation in CRISPR-based therapeutic genome
    • Authors: David A Scott, Feng Zhang
      Pages: 1095 - 1101
      Abstract: Analysis of the ExAC and 1000 Genomes data sets estimates the impact of inter-individual variation on the efficacy and safety of therapies based on CRISPR endonucleases.
      Citation: Nature Medicine 23, 1095 (2017)
      PubDate: 2017-07-31
      DOI: 10.1038/nm.4377
      Issue No: Vol. 23, No. 9 (2017)
  • Sex-specific transcriptional signatures in human depression
    • Authors: Benoit Labonté, Olivia Engmann, Immanuel Purushothaman, Caroline Menard, Junshi Wang, Chunfeng Tan, Joseph R Scarpa, Gregory Moy, Yong-Hwee E Loh, Michael Cahill, Zachary S Lorsch, Peter J Hamilton, Erin S Calipari, Georgia E Hodes, Orna Issler, Hope Kronman, Madeline Pfau, Aleksandar L J Obradovic, Yan Dong, Rachael L Neve, Scott Russo, Andrew Kazarskis, Carol Tamminga, Naguib Mechawar, Gustavo Turecki, Bin Zhang, Li Shen, Eric J Nestler
      Pages: 1102 - 1111
      Abstract: Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.
      Citation: Nature Medicine 23, 1102 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/nm.4386
      Issue No: Vol. 23, No. 9 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
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