Journal Cover Nature Genetics
  [SJR: 23.762]   [H-I: 469]   [498 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1061-4036 - ISSN (Online) 1546-1718
   Published by NPG Homepage  [135 journals]
  • An aberrant SREBP-dependent lipogenic program promotes metastatic prostate
           cancer
    • An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

      An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer, Published online: 15 January 2018; doi:10.1038/s41588-017-0027-2

      This study shows that inactivation of Pml in the mouse prostate turns indolent Pten-null tumors into lethal metastatic disease. The authors identify an aberrant SREBP prometastatic lipogenic program and show that a high-fat diet induces lipid accumulation in prostate tumors and is sufficient to drive metastasis.An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer, Published online: 2018-01-15; doi:10.1038/s41588-017-0027-22018-01-15
      DOI: 10.1038/s41588-017-0027-2
       
  • Pan-genome analysis highlights the extent of genomic variation in
           cultivated and wild rice
    • Pan-genome analysis highlights the extent of genomic variation in cultivated and wild rice

      Pan-genome analysis highlights the extent of genomic variation in cultivated and wild rice, Published online: 15 January 2018; doi:10.1038/s41588-018-0041-z

      A pan-genome dataset of the Oryza sativa–Oryza rufipogon species complex generated through deep sequencing and de novo genome assembly of 66 divergent accessions will be helpful in pinpointing new causal variants underlying complex traits and in promoting evolutionary and functional studies in rice.Pan-genome analysis highlights the extent of genomic variation in cultivated and wild rice, Published online: 2018-01-15; doi:10.1038/s41588-018-0041-z2018-01-15
      DOI: 10.1038/s41588-018-0041-z
       
  • Genetics of lipid metabolism in prostate cancer
    • Genetics of lipid metabolism in prostate cancer

      Genetics of lipid metabolism in prostate cancer, Published online: 15 January 2018; doi:10.1038/s41588-017-0037-0

      Dysregulated lipid metabolism is a prominent feature of prostate cancers. Two papers in this issue identify novel genomic drivers of lipid metabolism in prostate cancer and provide implications for the subtyping and treatment of the disease.Genetics of lipid metabolism in prostate cancer, Published online: 2018-01-15; doi:10.1038/s41588-017-0037-02018-01-15
      DOI: 10.1038/s41588-017-0037-0
       
  • Transposon-derived small RNAs triggered by miR845 mediate genome dosage
           response in Arabidopsis
    • Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis

      Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis, Published online: 15 January 2018; doi:10.1038/s41588-017-0032-5

      A conserved microRNA targets LTR retrotransposons in Arabidopsis pollen, stimulating epigenetically activated siRNAs in a dose-dependent manner through RNA Pol IV. These miR845b-dependent easiRNAs mediate the interploidy hybridization barrier that leads to seed abortion.Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis, Published online: 2018-01-15; doi:10.1038/s41588-017-0032-52018-01-15
      DOI: 10.1038/s41588-017-0032-5
       
  • Transcription factors orchestrate dynamic interplay between genome
           topology and gene regulation during cell reprogramming
    • Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

      Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming, Published online: 15 January 2018; doi:10.1038/s41588-017-0030-7

      The authors analyze time-resolved changes in genome topology, gene expression, transcription-factor binding, and chromatin state during iPSC generation. They conclude that 3D genome reorganization generally precedes gene expression changes and that removal of locus-specific topological barriers explains why pluripotency genes are activated sequentially during reprogramming.Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming, Published online: 2018-01-15; doi:10.1038/s41588-017-0030-72018-01-15
      DOI: 10.1038/s41588-017-0030-7
       
  • Compartmentalized activities of the pyruvate dehydrogenase complex sustain
           lipogenesis in prostate cancer
    • Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

      Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer, Published online: 15 January 2018; doi:10.1038/s41588-017-0026-3

      Inactivation of pyruvate dehydrogenase A1 (PDHA1), a subunit of the pyruvate dehydrogenase complex (PDC) regulating mitochondrial metabolism, inhibits lipid biosynthesis and prostate cancer development in mouse and human xenograft tumor models.Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer, Published online: 2018-01-15; doi:10.1038/s41588-017-0026-32018-01-15
      DOI: 10.1038/s41588-017-0026-3
       
  • Paternal easiRNAs regulate parental genome dosage in Arabidopsis
    • Paternal easiRNAs regulate parental genome dosage in Arabidopsis

      Paternal easiRNAs regulate parental genome dosage in Arabidopsis, Published online: 15 January 2018; doi:10.1038/s41588-017-0033-4

      Depletion of easiRNAs (epigenetically activated small interfering RNAs) relieves the triploid block reproduction barrier mediated by increased paternal ploidy in Arabidposis. Loss of RNA Pol IV blocks easiRNA formation and rescues triploid seeds.Paternal easiRNAs regulate parental genome dosage in Arabidopsis, Published online: 2018-01-15; doi:10.1038/s41588-017-0033-42018-01-15
      DOI: 10.1038/s41588-017-0033-4
       
  • Reconstructing an African haploid genome from the 18th century
    • Reconstructing an African haploid genome from the 18th century

      Reconstructing an African haploid genome from the 18th century, Published online: 15 January 2018; doi:10.1038/s41588-017-0031-6

      Reconstructing the genome of an ancestor: 788 Icelanders are descended from a man who arrived there in 1802. 38% of his African mother’s genome has now been reconstructed from their pedigree and the genomes and genotypes of current Icelanders up to 8 generations later.Reconstructing an African haploid genome from the 18th century, Published online: 2018-01-15; doi:10.1038/s41588-017-0031-62018-01-15
      DOI: 10.1038/s41588-017-0031-6
       
 
 
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