Journal Cover Nature Cell Biology
  [SJR: 14.131]   [H-I: 294]   [406 followers]  Follow
    
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   ISSN (Print) 1465-7392 - ISSN (Online) 1476-4679
   Published by NPG Homepage  [135 journals]
  • A transient pool of nuclear F-actin at mitotic exit controls chromatin
           organization
    • A transient pool of nuclear F-actin at mitotic exit controls chromatin organization

      A transient pool of nuclear F-actin at mitotic exit controls chromatin organization, Published online: 13 November 2017; doi:10.1038/ncb3641

      NatureArticleSnippet(type=short-summary, markup=

      Baarlink et al. identify a transient pool of nuclear F-actin, the dynamics of which are controlled by cofilin-1 that accumulates after mitosis and is important for chromatin reorganization in G1.

      , isJats=true)A transient pool of nuclear F-actin at mitotic exit controls chromatin organization, Published online: 2017-11-13; doi:10.1038/ncb36412017-11-13
      DOI: 10.1038/ncb3641
       
  • PARPi focus the spotlight on replication fork protection in cancer
    • PARPi focus the spotlight on replication fork protection in cancer

      PARPi focus the spotlight on replication fork protection in cancer, Published online: 31 October 2017; doi:10.1038/ncb3638

      NatureArticleSnippet(type=standfirst, markup=

      PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.

      , isJats=true)PARPi focus the spotlight on replication fork protection in cancer, Published online: 2017-10-31; doi:10.1038/ncb36382017-10-31
      DOI: 10.1038/ncb3638
       
  • Implantable synthetic organoid matrices for intestinal regeneration
    • Implantable synthetic organoid matrices for intestinal regeneration

      Implantable synthetic organoid matrices for intestinal regeneration, Published online: 31 October 2017; doi:10.1038/ncb3635

      NatureArticleSnippet(type=standfirst, markup=

      Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.

      , isJats=true)Implantable synthetic organoid matrices for intestinal regeneration, Published online: 2017-10-31; doi:10.1038/ncb36352017-10-31
      DOI: 10.1038/ncb3635
       
  • TYRP1 mRNA goes fishing for miRNAs in melanoma
    • TYRP1 mRNA goes fishing for miRNAs in melanoma

      TYRP1 mRNA goes fishing for miRNAs in melanoma, Published online: 31 October 2017; doi:10.1038/ncb3637

      NatureArticleSnippet(type=standfirst, markup=

      A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.

      , isJats=true) TYRP1 mRNA goes fishing for miRNAs in melanoma, Published online: 2017-10-31; doi:10.1038/ncb36372017-10-31
      DOI: 10.1038/ncb3637
       
  • Reforms spell optimism for biological research in China
    • Reforms spell optimism for biological research in China

      Reforms spell optimism for biological research in China, Published online: 31 October 2017; doi:10.1038/ncb3639

      NatureArticleSnippet(type=standfirst, markup=

      A series of government reforms aim to enhance basic research efforts in China with a shift in focus from quantity to quality.

      , isJats=true)Reforms spell optimism for biological research in China, Published online: 2017-10-31; doi:10.1038/ncb36392017-10-31
      DOI: 10.1038/ncb3639
       
  • Erratum: Super-resolution microscopy reveals that disruption of ciliary
           transition-zone architecture causes Joubert syndrome
    • Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome

      Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome, Published online: 31 October 2017; doi:10.1038/ncb3622

      Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome, Published online: 2017-10-31; doi:10.1038/ncb36222017-10-31
      DOI: 10.1038/ncb3622
       
  • TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at
           the trans-Golgi
    • TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi

      Nature Cell Biology, Published online: 30 October 2017; doi:10.1038/ncb3627

      Shin et al. identify TBC1D23 as an adaptor that interacts both with golgins and endosomal WASH and is required for the delivery of endosome-derived vesicles to the trans-Golgi.

      Nature Cell Biology, Published online: 30 October 2017; doi:10.1038/ncb36272017-10-30
      DOI: 10.1038/ncb3627
       
  • Class III phosphatidylinositol-3-OH kinase controls epithelial integrity
           through endosomal LKB1 regulation
    • Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

      Nature Cell Biology, Published online: 30 October 2017; doi:10.1038/ncb3631

      O’Farrell et al. show that class III PI3K regulates epithelial integrity through endosomal LKB1. Class III PI3K inactivation dysregulates LKB1 to alter cell polarity, and the PtdIns3P effector WDFY2 regulates LKB1.

      Nature Cell Biology, Published online: 30 October 2017; doi:10.1038/ncb36312017-10-30
      DOI: 10.1038/ncb3631
       
 
 
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