Journal Cover Nature Cell Biology
  [SJR: 14.131]   [H-I: 294]   [425 followers]  Follow
    
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   ISSN (Print) 1465-7392 - ISSN (Online) 1476-4679
   Published by NPG Homepage  [135 journals]
  • Transient Scute activation via a self-stimulatory loop directs
           enteroendocrine cell pair specification from self-renewing intestinal stem
           cells
    • Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

      Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells, Published online: 15 January 2018; doi:10.1038/s41556-017-0020-0

      Chen et al. demonstrate that transient Scute activation induces asymmetric division in Drosophila intestinal stem cells, which generates enteroendocrine progenitor cells that divide once before differentiation to yield a pair of enteroendocrine cells.Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells, Published online: 2018-01-15; doi:10.1038/s41556-017-0020-02018-01-15
      DOI: 10.1038/s41556-017-0020-0
       
  • Segregation of mitochondrial DNA heteroplasmy through a developmental
           genetic bottleneck in human embryos
    • Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

      Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos, Published online: 15 January 2018; doi:10.1038/s41556-017-0017-8

      Floros et al. show that mtDNA copy number is reduced and non-synonymous mtDNA mutations are eliminated to prevent mtDNA mutation accumulation in germ cells during human primordial germ cell development.Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos, Published online: 2018-01-15; doi:10.1038/s41556-017-0017-82018-01-15
      DOI: 10.1038/s41556-017-0017-8
       
  • Myosin-Va is required for preciliary vesicle transportation to the mother
           centriole during ciliogenesis
    • Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis

      Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis, Published online: 15 January 2018; doi:10.1038/s41556-017-0018-7

      Wu et al. show that myosin-Va is needed for the initiation of primary cilia formation by transporting preciliary vesicles to the distal appendages of the mother centriole in a manner dependent on both microtubules and centrosomal actin.Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis, Published online: 2018-01-15; doi:10.1038/s41556-017-0018-72018-01-15
      DOI: 10.1038/s41556-017-0018-7
       
  • EXD2 governs germ stem cell homeostasis and lifespan by promoting
           mitoribosome integrity and translation
    • EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation

      EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation, Published online: 15 January 2018; doi:10.1038/s41556-017-0016-9

      By analysing the exonuclease EXD2, Silva et al. find that it localizes to mitochondria, and that its loss alters metabolism by affecting mitochondrial translation and causes developmental delay and lifespan extension in flies.EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation, Published online: 2018-01-15; doi:10.1038/s41556-017-0016-92018-01-15
      DOI: 10.1038/s41556-017-0016-9
       
  • Author Correction: TBC1D23 is a bridging factor for endosomal vesicle
           capture by golgins at the trans-Golgi
    • Author Correction: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi

      Author Correction: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi, Published online: 08 January 2018; doi:10.1038/s41556-017-0026-7

      Author Correction: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-GolgiAuthor Correction: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi, Published online: 2018-01-08; doi:10.1038/s41556-017-0026-72018-01-08
      DOI: 10.1038/s41556-017-0026-7
       
  • Defining murine organogenesis at single-cell resolution reveals a role for
           the leukotriene pathway in regulating blood progenitor formation
    • Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation

      Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation, Published online: 08 January 2018; doi:10.1038/s41556-017-0013-z

      Ibarra-Soria et al. study cellular diversity, transcriptional signatures, lineage specification and somitogenesis on a single-cell level in E8.25 mouse embryos, and reveal the regulation of blood progenitor formation by the leukotriene pathway.Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation, Published online: 2018-01-08; doi:10.1038/s41556-017-0013-z2018-01-08
      DOI: 10.1038/s41556-017-0013-z
       
  • PERK links the clock and protein stress in cancer
    • PERK links the clock and protein stress in cancer

      PERK links the clock and protein stress in cancer, Published online: 21 December 2017; doi:10.1038/s41556-017-0019-6

      The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.PERK links the clock and protein stress in cancer, Published online: 2017-12-21; doi:10.1038/s41556-017-0019-62017-12-21
      DOI: 10.1038/s41556-017-0019-6
       
  • Sugar fuels T-cell memory
    • Sugar fuels T-cell memory

      Sugar fuels T-cell memory, Published online: 21 December 2017; doi:10.1038/s41556-017-0014-y

      Previous work has highlighted the role of metabolic shifts in regulating the formation of memory T cells, which are generated during a primary infection to provide long-lasting immunity. A study now shows that memory T cells rely on a gluconeogenesis–glycogenolysis cycle to provide antioxidant defence and support their survival.Sugar fuels T-cell memory, Published online: 2017-12-21; doi:10.1038/s41556-017-0014-y2017-12-21
      DOI: 10.1038/s41556-017-0014-y
       
 
 
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