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Journal Cover Nature Cell Biology
  [SJR: 14.131]   [H-I: 294]   [391 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 1465-7392 - ISSN (Online) 1476-4679
   Published by NPG Homepage  [135 journals]
  • Principles of refereeing
    • Pages: 1005 - 1005
      Abstract: Peer review is a key element of scientific publishing. Here we discuss what constitutes the ideal referee report.
      Citation: Nature Cell Biology 19, 1005 (2017)
      PubDate: 2017-08-31
      DOI: 10.1038/ncb3606
      Issue No: Vol. 19, No. 9 (2017)
  • Enhancing brown fat with NFIA
    • Authors: Suzanne N. Shapira, Patrick Seale
      Pages: 1006 - 1007
      Abstract: Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
      Citation: Nature Cell Biology 19, 1006 (2017)
      PubDate: 2017-08-31
      DOI: 10.1038/ncb3591
      Issue No: Vol. 19, No. 9 (2017)
  • DNA sensing in senescence
    • Authors: Marina Ruiz de Galarreta, Amaia Lujambio
      Pages: 1008 - 1009
      Abstract: Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.
      Citation: Nature Cell Biology 19, 1008 (2017)
      PubDate: 2017-08-31
      DOI: 10.1038/ncb3603
      Issue No: Vol. 19, No. 9 (2017)
  • Lab-grown mini-brains upgraded
    • Authors: Lin Yang, Huck-Hui Ng
      Pages: 1010 - 1012
      Abstract: Three-dimensional brain organoid models have come into the spotlight as in vitro tools to recapitulate complex features of the brain. Four recent papers now leverage current technologies to generate new flavours of brain organoids and address aspects of brain biology which, to date, have been challenging to explore.
      Citation: Nature Cell Biology 19, 1010 (2017)
      PubDate: 2017-08-31
      DOI: 10.1038/ncb3601
      Issue No: Vol. 19, No. 9 (2017)
  • A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation
    • Authors: Clea Bárcena, Carlos López-Otín
      Pages: 1012 - 1013
      Abstract: Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.
      Citation: Nature Cell Biology 19, 1012 (2017)
      PubDate: 2017-08-31
      DOI: 10.1038/ncb3602
      Issue No: Vol. 19, No. 9 (2017)
  • A caspase-independent way to kill cancer cells
    • Authors: Brent E. Fitzwalter, Andrew Thorburn
      Pages: 1014 - 1015
      Abstract: Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.
      Citation: Nature Cell Biology 19, 1014 (2017)
      PubDate: 2017-08-31
      DOI: 10.1038/ncb3604
      Issue No: Vol. 19, No. 9 (2017)
  • Lactate dehydrogenase activity drives hair follicle stem cell activation
    • Authors: Aimee Flores, John Schell, Abigail S. Krall, David Jelinek, Matilde Miranda, Melina Grigorian, Daniel Braas, Andrew C. White, Jessica L. Zhou, Nicholas A. Graham, Thomas Graeber, Pankaj Seth, Denis Evseenko, Hilary A. Coller, Jared Rutter, Heather R. Christofk, William E. Lowry
      Pages: 1017 - 1026
      Abstract: Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.
      Citation: Nature Cell Biology 19, 1017 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/ncb3575
      Issue No: Vol. 19, No. 9 (2017)
  • Control of intestinal stem cell function and proliferation by
           mitochondrial pyruvate metabolism
    • Authors: John C. Schell, Dona R. Wisidagama, Claire Bensard, Helong Zhao, Peng Wei, Jason Tanner, Aimee Flores, Jeffrey Mohlman, Lise K. Sorensen, Christian S. Earl, Kristofor A. Olson, Ren Miao, T. Cameron Waller, Don Delker, Priyanka Kanth, Lei Jiang, Ralph J. DeBerardinis, Mary P. Bronner, Dean Y. Li, James E. Cox, Heather R. Christofk, William E. Lowry, Carl S. Thummel, Jared Rutter
      Pages: 1027 - 1036
      Abstract: Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.
      Citation: Nature Cell Biology 19, 1027 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/ncb3593
      Issue No: Vol. 19, No. 9 (2017)
  • ZSCAN10 expression corrects the genomic instability of iPSCs from aged
    • Authors: Maria Skamagki, Cristina Correia, Percy Yeung, Timour Baslan, Samuel Beck, Cheng Zhang, Christian A. Ross, Lam Dang, Zhong Liu, Simona Giunta, Tzu-Pei Chang, Joye Wang, Aparna Ananthanarayanan, Martina Bohndorf, Benedikt Bosbach, James Adjaye, Hironori Funabiki, Jonghwan Kim, Scott Lowe, James J. Collins, Chi-Wei Lu, Hu Li, Rui Zhao, Kitai Kim
      Pages: 1037 - 1048
      Abstract: Skamagki et al. show that pluripotency factor ZSCAN10 is poorly expressed in iPSCs derived from aged donors, and its addition during reprogramming restores the DNA damage response and genomic stability through normalization of ROS–glutathione levels.
      Citation: Nature Cell Biology 19, 1037 (2017)
      PubDate: 2017-08-28
      DOI: 10.1038/ncb3598
      Issue No: Vol. 19, No. 9 (2017)
  • An apical MRCK-driven morphogenetic pathway controls epithelial polarity
    • Authors: Ceniz Zihni, Evi Vlassaks, Stephen Terry, Jeremy Carlton, Thomas King Chor Leung, Michael Olson, Franck Pichaud, Maria Susana Balda, Karl Matter
      Pages: 1049 - 1060
      Abstract: Zihni et al. discover a role for Cdc42–MRCK signalling in establishing contractility at the apical pole, which in turn controls epithelial polarity in mammalian cells and Drosophila photoreceptors.
      Citation: Nature Cell Biology 19, 1049 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/ncb3592
      Issue No: Vol. 19, No. 9 (2017)
  • Innate immune sensing of cytosolic chromatin fragments through cGAS
           promotes senescence
    • Authors: Selene Glück, Baptiste Guey, Muhammet Fatih Gulen, Katharina Wolter, Tae-Won Kang, Niklas Arndt Schmacke, Anne Bridgeman, Jan Rehwinkel, Lars Zender, Andrea Ablasser
      Pages: 1061 - 1070
      Abstract: Glück et al. find that the DNA-sensing component cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments produced in senescent cells leading to STING-mediated production of SASPs, which promotes paracrine senescence.
      Citation: Nature Cell Biology 19, 1061 (2017)
      PubDate: 2017-07-31
      DOI: 10.1038/ncb3586
      Issue No: Vol. 19, No. 9 (2017)
  • SMC complexes differentially compact mitotic chromosomes according to
           genomic context
    • Authors: Stephanie Andrea Schalbetter, Anton Goloborodko, Geoffrey Fudenberg, Jon-Matthew Belton, Catrina Miles, Miao Yu, Job Dekker, Leonid Mirny, Jonathan Baxter
      Pages: 1071 - 1080
      Abstract: Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.
      Citation: Nature Cell Biology 19, 1071 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/ncb3594
      Issue No: Vol. 19, No. 9 (2017)
  • NFIA co-localizes with PPARγ and transcriptionally controls the brown
           fat gene program
    • Authors: Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake, Gaku Nagano, Ryo Nakaki, Ken Suzuki, Hirofumi Kobayashi, Shogo Yamamoto, Wei Sun, Tomohisa Aoyama, Yusuke Hirota, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Andrew P. White, Yu-Hua Tseng, Aaron M. Cypess, Therese J. Larsen, Naja Z. Jespersen, Camilla Scheele, Shuichi Tsutsumi, Hiroyuki Aburatani, Toshimasa Yamauchi, Takashi Kadowaki
      Pages: 1081 - 1092
      Abstract: Hiraike et al. identify nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat. NFIA activates cell-type-specific enhancers prior to differentiation and facilitates PPARγ binding to regulate the brown fat gene program.
      Citation: Nature Cell Biology 19, 1081 (2017)
      PubDate: 2017-08-14
      DOI: 10.1038/ncb3590
      Issue No: Vol. 19, No. 9 (2017)
  • Early loss of Crebbp confers malignant stem cell properties on lymphoid
    • Authors: Sarah J. Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G. Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q. Du, David J. Adams, Brian J. P. Huntly
      Pages: 1093 - 1104
      Abstract: Horton et al. show that early Crebbp loss in haematopoietic progenitors results in a defective p53-mediated DNA damage response, leading to the accumulation of epigenetic and genetic alterations, which promote the onset of lymphoid malignancies.
      Citation: Nature Cell Biology 19, 1093 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/ncb3597
      Issue No: Vol. 19, No. 9 (2017)
  • A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour
    • Authors: Simon Grelet, Laura A. Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy, Vamsi K. Gangaraju, J. Alan Diehl, Philip H. Howe
      Pages: 1105 - 1115
      Abstract: Grelet et al. find that hnRNP E1 release from PNUTS pre-RNA in response to TGFβ generates a lncRNA that acts as competitive sponge for miR-205, promoting epithelial–mesenchymal transition in cancer.
      Citation: Nature Cell Biology 19, 1105 (2017)
      PubDate: 2017-08-21
      DOI: 10.1038/ncb3595
      Issue No: Vol. 19, No. 9 (2017)
  • Mitochondrial permeabilization engages NF-╬║B-dependent anti-tumour
           activity under caspase┬ádeficiency
    • Authors: Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, Florian Bock, Catherine Cloix, Kai Cao, Alba Roca, Jonathan Lopez, Gabriel Ichim, Emma Proïcs, Camila Rubio-Patiño, Loic Fort, Nader Yatim, Emma Woodham, Susana Orozco, Lucia Taraborrelli, Nieves Peltzer, Daniele Lecis, Laura Machesky, Henning Walczak, Matthew L. Albert, Simon Milling, Andrew Oberst, Jean-Ehrland Ricci, Kevin M. Ryan, Karen Blyth, Stephen W. G. Tait
      Pages: 1116 - 1129
      Abstract: Tait and colleagues show that caspase-independent cell death induced by mitochondrial permeabilization stimulates NF-κB activity through downregulation of inhibitor of apoptosis, and enhances anti-tumour effects.
      Citation: Nature Cell Biology 19, 1116 (2017)
      PubDate: 2017-08-28
      DOI: 10.1038/ncb3596
      Issue No: Vol. 19, No. 9 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
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