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Kidney International
Journal Prestige (SJR): 3.238
Citation Impact (citeScore): 5
Number of Followers: 46  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0085-2538 - ISSN (Online) 1523-1755
Published by NPG Homepage  [143 journals]
  • Title Page

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      Citation: Kidney International 100, 4 (2021)
      PubDate: 2021-10
      DOI: 10.1016/S0085-2538(21)00814-0
      Issue No: Vol. 100, No. 4 (2021)
       
  • Subscription Information

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      Citation: Kidney International 100, 4 (2021)
      PubDate: 2021-10
      DOI: 10.1016/S0085-2538(21)00813-9
      Issue No: Vol. 100, No. 4 (2021)
       
  • KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular
           Diseases

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      Authors: Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group
      Abstract: This guideline is published as a supplement supported by KDIGO. The development and publication of this guideline are strictly funded by KDIGO, and neither KDIGO nor its guideline Work Group members sought or received monies or fees from corporate or commercial entities in connection with this work. The opinions or views expressed in this professional education supplement are those of the authors and do not necessarily reflect the opinions or recommendations of the International Society of Nephrology or Elsevier.
      Citation: Kidney International 100, 4 (2021)
      PubDate: 2021-10
      DOI: 10.1016/j.kint.2021.05.021
      Issue No: Vol. 100, No. 4 (2021)
       
  • A key gene in Drosophila eye development provides protection for tubules
           and glomeruli upon injury

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      Authors: Lisa Turinsky; Fabiola Terzi
      Abstract: Dachshund homolog 1 (DACH1) is highly expressed in both the developing kidney, where it has a role in kidney development, and in the adult kidney, where we know very little about its role. Recently, two groups independently reported that DACH1 protects podocytes1 and tubules2 from experimental injury and provided promising evidence that their findings may be relevant to human chronic kidney disease (CKD).
      Citation: Kidney International (2021)
      PubDate: 2021-10-12
      DOI: 10.1016/j.kint.2021.09.021
       
  • Mendelian randomization to assess causality between uromodulin, blood
           pressure and chronic kidney disease.

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      Authors: Belen Ponte; Marie C. Sadler, Eric Olinger, Peter Vollenweider, Murielle Bochud, Sandosh Padmanabhan, Caroline Hayward, Zoltán Kutalik, Olivier Devuyst
      Abstract: UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect functional kidney tubular mass in observational studies, questioning the causal link between uromodulin production and kidney damage. We used Mendelian randomization to clarify causality between uUMOD levels, kidney function and blood pressure in individuals of European descent. The link between uUMOD and estimated glomerular filtration rate (eGFR) was first investigated in a population-based cohort of 3,851 individuals.
      Citation: Kidney International (2021)
      PubDate: 2021-10-08
      DOI: 10.1016/j.kint.2021.08.032
       
  • Loss of proximal tubular transcription factor Krüppel-like factor 15
           exacerbates kidney injury through loss of fatty acid oxidation.

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      Authors: Sian E. Piret; Ahmed A. Attallah, Xiangchen Gu, Yiqing Guo, Nehaben A. Gujarati, Justina Henein, Amy Zollman, Takashi Hato, Avi Ma’ayan, Monica P. Revelo, Kathleen G. Dickman, Chung-Hsin Chen, Chia-Tung Shun, Thomas A. Rosenquist, John C. He, Sandeep K. Mallipattu
      Abstract: Loss of fatty acid β-oxidation (FAO) in the proximal tubule is a critical mediator of acute kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal tubule injury remain understudied. Krüppel-like factor 15 (KLF15), a highly enriched zinc-finger transcription factor in the proximal tubule , was significantly reduced in proximal tubule cells after aristolochic acid I (AAI) treatment, a proximal tubule-specific injury model. Proximal tubule specific knockout of Klf15 exacerbated proximal tubule injury and kidney function decline compared to control mice during the active phase of AAI treatment, and after ischemia-reperfusion injury.
      Citation: Kidney International (2021)
      PubDate: 2021-10-08
      DOI: 10.1016/j.kint.2021.08.031
       
  • Ultrasound renal denervation for hypertension: impact of the
           RADIANCE-HTN-TRIO trial on future management of resistant hypertension

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      Authors: Fernando Elijovich
      Abstract: Refers to: Azizi M, Sanghvi K, Saxena M, et al. Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial. Lancet. 2021;397:2476–2486. https://doi.org/10.1016/S0140-6736(2100788-1)
      Citation: Kidney International (2021)
      PubDate: 2021-10-04
      DOI: 10.1016/j.kint.2021.09.017
       
  • Highly Multiplexed Immunofluorescence of the Human Kidney using
           Co-Detection by Indexing

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      Authors: Elizabeth K. Neumann; Nathan Heath Patterson, Emilio S. Rivera, Jamie L. Allen, Maya Brewer, Mark P. deCaestecker, Richard M. Caprioli, Agnes B. Fogo, Jeffrey M. Spraggins
      Abstract: The human kidney is composed of many cell types that vary in their abundance and distribution from normal to diseased organ. As these cell types perform unique and essential functions, it is important to confidently label each within a single tissue to accurately assess tissue architecture and microenvironments. Towards this goal, we demonstrate the use of co-detection by indexing (CODEX) multiplexed immunofluorescence for visualizing 23 antigens within the human kidney. Using CODEX, many of the major cell types and substructures, such as collecting ducts, glomeruli, and thick ascending limb, were visualized within a single tissue section.
      Citation: Kidney International (2021)
      PubDate: 2021-10-04
      DOI: 10.1016/j.kint.2021.08.033
       
  • Improved cellular and humoral immunity upon a second BNT162b2 and
           mRNA-1273 boost in prime-boost vaccination no/low responders with
           end-stage renal disease

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      Authors: Ulrik Stervbo; Arturo Blazquez-Navarro, Elena Vidal Blanco, Lema Safi, Toni L. Meister, Krystallenia Paniskaki, Mara Stockhausen, Corinna Marheinecke, Gert Zimmer, Jacqueline Wellenkötter, Tina Giglio, Prerna Arora, Stefan Pöhlmann, Markus Hoffmann, Felix S. Seibert, Stephanie Pfaender, Toralf Roch, Timm H. Westhoff, Okan Cinkilic, Nina Babel
      Abstract: Patients with end-stage renal disease (ESRD) develop inefficient immune responses upon vaccination and have a high-risk of developing severe COVID-19. The globally expanding SARS-CoV-2 variant of concern (VOC), B.1.6.17.2/Delta, evades immune responses and might constitute a particular threat to these patients. 1–3
      Citation: Kidney International (2021)
      PubDate: 2021-10-04
      DOI: 10.1016/j.kint.2021.09.015
       
  • Antibody and T cell response to a third dose of SARS-CoV-2 messenger RNA
           BNT162b2 vaccine in kidney transplant recipients.

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      Authors: Dominique Bertrand; Mouad Hamzaoui, Veronique Lemée, Julie Lamulle, Charlotte Laurent, Isabelle Etienne, Mathilde Lemoine, Ludivine Lebourg, Mélanie Hanoy, Frank Le Roy, Dorian Nezam, Fabienne Farce, Jean-Christophe Plantier, Olivier Boyer, Dominique Guerrot, Sophie Candon
      Abstract: SARS-CoV-2 vaccination has become the standard of care for the prevention of severe COVID-19, with a strongly positive impact in countries in which vaccination has been effectively promoted S1. In KTR, SARS-CoV-2 vaccination has been recommended through international guidelines S2. Unfortunately, the data reported in KTR are disappointing, with a low rate of seroconversion after 2 doses 1, while the occurrence of severe infection after vaccination 2 is of concern. In this context, as of April 6 2021, the French Administration recommends that solid organ transplants (SOT) recipients receive a third mRNA vaccine dose at least 4 weeks after the second dose.
      Citation: Kidney International (2021)
      PubDate: 2021-10-04
      DOI: 10.1016/j.kint.2021.09.014
       
  • Kidney toxicity of phosphate: is that crystal clear yet'

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      Authors: Emmanuel Letavernier; Tilman B. Drüeke
      Abstract: Refers to:
      Citation: Kidney International (2021)
      PubDate: 2021-10-04
      DOI: 10.1016/j.kint.2021.08.030
       
  • The Lupus Nephritis Management Renaissance

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      Authors: Juan M. Mejia-Vilet; Ana Malvar, Arnon Arazi, Brad H. Rovin
      Abstract: Over the past year, and for the first time ever, the United States Food and Drug Administration approved two drugs specifically for the treatment of lupus nephritis (LN). As the lupus community works toward understanding how to best use these new therapies, it is also an ideal time to begin to rethink the overall management strategy of LN. In addition to new drugs, this must include how to use kidney biopsies for management and not just diagnosis, how molecular technologies can be applied to interrogate biopsies and how such data can impact management, and how to incorporate LN biomarkers into management paradigms.
      Citation: Kidney International (2021)
      PubDate: 2021-10-03
      DOI: 10.1016/j.kint.2021.09.012
       
  • Anticoagulation in patients with kidney failure on dialysis: factor XI as
           a therapeutic target

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      Authors: John Eikelboom; Jürgen Floege, Ravi Thadhani, Jeffrey I. Weitz, Wolfgang C. Winkelmayer
      Abstract: Chronic kidney disease (CKD) is present in almost 10% of the world population and is associated with excess mortality and morbidity. Reduced glomerular filtration rate and the presence and extent of proteinuria, key domains of CKD, have both been shown to be strong and independent risk factors for cardiovascular disease. Patients with kidney failure requiring dialysis are at highest risk for cardiovascular events, for example, stroke or myocardial infarction, and of developing chronic cardiovascular conditions, such as heart failure.
      Citation: Kidney International (2021)
      PubDate: 2021-09-30
      DOI: 10.1016/j.kint.2021.08.028
       
  • Contactin-1 is a novel target antigen in membranous nephropathy associated
           with chronic inflammatory demyelinating polyneuropathy.

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      Authors: Moglie Le Quintrec; Maxime Teisseyre, Nicole Bec, Emilien Delmont, Ilan Szwarc, Hélène Perrochia, Marie Christine Machet, Anthony Chauvin, Nicolas Mavroudakis, Guillaume Taieb, Luca Lanfranco, Claire Rigothier, Boucraut José, Catalano Concetta, Clair Geneste, Vincent Pernin, Christian Larroque, Jérôme Devaux, Anaïs Beyze
      Abstract: Primary membranous nephropathy (MN) is an autoimmune glomerular disease in which autoantibodies are directed against podocyte proteins. In about 80% of cases the main targeted antigen is the phospholipase A2 receptor 1 (PLA2R1). Anti-PLA2R1 antibodies are mainly immunoglobulin G type 4 (IgG4). However, the antigenic target remains to be defined in 20% of cases. MN can be associated with chronic inflammatory demyelinating polyneuropathy, an autoimmune disease of the peripheral nervous system where a common antigenic target has yet to be identified.
      Citation: Kidney International (2021)
      PubDate: 2021-09-30
      DOI: 10.1016/j.kint.2021.08.014
       
  • Effect of disease progression on the podocyte cell cycle in Alport
           Syndrome

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      Authors: Camille Nicolas Frank; Xiaogang Hou, Astgik Petrosyan, Valentina Villani, Rui Zhao, Joshua R. Hansen, Geremy Clair, Fadi Salem, Roger E. De Filippo, Paolo Cravedi, Kevin V. Lemley, Laura Perin
      Abstract: Progression of glomerulosclerosis is associated with loss of podocytes with subsequent glomerular tuft instability. It is thought that a diminished number of podocytes may be able to preserve tuft stability through cell hypertrophy associated with cell cycle re-entry. At the same time, reentry into the cell cycle risks podocyte detachment if podocytes cross the G1/S checkpoint and undergo abortive cytokinesis. In order to study cell cycle dynamics during chronic kidney disease (CKD) development, we used a FUCCI model (fluorescence ubiquitination-based cell cycle indicator) of mice with X-linked Alport Syndrome.
      Citation: Kidney International (2021)
      PubDate: 2021-09-22
      DOI: 10.1016/j.kint.2021.08.026
       
  • New onset systemic lupus erythematosus opening as class V lupus nephritis
           after COVID-19 vaccination

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      Authors: María Fernanda Zavala-Miranda; Samantha G. González-Ibarra, Abril A. Pérez-Arias, Norma O. Uribe-Uribe, Juan M. Mejia-Vilet
      Abstract: To the editor:
      Citation: Kidney International (2021)
      PubDate: 2021-09-21
      DOI: 10.1016/j.kint.2021.09.009
       
  • A pre-specified analysis of the Dapagliflozin and Prevention of Adverse
           Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial
           on the incidence of abrupt declines in kidney function.

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      Authors: Hiddo JL. Heerspink; David Cherney, Douwe Postmus, Bergur V. Stefánsson, Glenn M. Chertow, Jamie P. Dwyer, Tom Greene, Mikhail Kosiborod, Anna Maria Langkilde, John JV. McMurray, Ricardo Correa-Rotter, Peter Rossing, C David Sjöström, Robert D. Toto, David C. Wheeler, DAPA-CKD trial committees investigators
      Abstract: This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high risk patients based on having chronic kidney disease (CKD) and severe albuminuria. DAPA-CKD was a randomized, double-blind, placebo-controlled trial had a median follow-up of 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200–5000 mg/g and estimated glomerular filtration rate 25–75 mL/min/1.73m2) were randomized to dapagliflozin 10 mg/day matched to placebo (2152 individuals each).
      Citation: Kidney International (2021)
      PubDate: 2021-09-21
      DOI: 10.1016/j.kint.2021.09.005
       
  • A secondary analysis of the Belimumab International Study in Lupus
           Nephritis trial examined effects of belimumab on kidney outcomes and
           preservation of kidney function in patients with lupus nephritis.

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      Authors: Brad H. Rovin; Richard Furie, Y.K. Onno Teng, Gabriel Contreras, Ana Malvar, Xueqing Yu, Beulah Ji, Yulia Green, Tania Gonzalez-Rivera, Damon Bass, Jennifer Gilbride, Chun-Hang Tang, David A. Roth
      Abstract: We performed a post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN), a Phase 3, multinational, double-blind, 104-week trial, in which 448 patients with lupus nephritis were randomized to receive intravenous belimumab 10 mg/kg or placebo with standard therapy (cyclophosphamide/azathioprine or mycophenolate mofetil). Add-on belimumab was found to be most effective in improving the primary efficacy kidney response and complete kidney response in patients with proliferative lupus nephritis and a baseline urine protein/creatinine ratio under 3 g/g.
      Citation: Kidney International (2021)
      PubDate: 2021-09-21
      DOI: 10.1016/j.kint.2021.08.027
       
  • Combination treatment with rituximab, low-dose cyclophosphamide and plasma
           exchange for severe antineutrophil cytoplasmic antibody-associated
           vasculitis.

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      Authors: Kavita Gulati; Helena Edwards, Maria Prendecki, Thomas D. Cairns, Marie Condon, Jack Galliford, Megan Griffith, Jeremy B. Levy, Frederick W.K. Tam, Anisha Tanna, Charles D. Pusey, Stephen P. McAdoo
      Abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis can present with life-threatening lung-kidney syndromes. However, many controlled treatment trials excluded patients with diffuse alveolar hemorrhage or severely impaired glomerular filtration rates, and so the optimum treatment in these cases is unclear. In this retrospective cohort study, we report the outcomes of 64 patients with life-threatening disease treated with a combination regimen of rituximab, low-dose intravenous cyclophosphamide, oral glucocorticoids, and plasma exchange.
      Citation: Kidney International (2021)
      PubDate: 2021-09-21
      DOI: 10.1016/j.kint.2021.08.025
       
  • A mutation in the SAA1 promoter causes hereditary amyloid A amyloidosis.

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      Authors: Jakub Sikora; Tereza Kmochová, Dita Mušálková, Michal Pohludka, Petr Přikryl, Hana Hartmannová, Kateřina Hodaňová, Helena Trešlová, Lenka Nosková, Lenka Mrázová, Viktor Stránecký, Mariia Lunová, Milan Jirsa, Eva Honsová, Surendra Dasari, Ellen D. McPhail, Nelson Leung, Martina Živná, Anthony J. Bleyer, Ivan Rychlík, Romana Ryšavá, Stanislav Kmoch
      Abstract: Amyloid A amyloidosis is a serious clinical condition resulting from the systemic deposition of amyloid A originating from serum amyloid A proteins with the kidneys being the most commonly and earliest affected organ. Previously described amyloid A amyloidosis is linked to increased production and deposition of serum amyloid A proteins secondary to inflammatory conditions arising from infectious, metabolic, or genetic causes. Here we describe a family with primary amyloid A amyloidosis due to a chr11:18287683 T>C (human genome version19) mutation in the SAA1 promoter linked to the amyloidogenic SAA1.1 haplotype.
      Citation: Kidney International (2021)
      PubDate: 2021-09-20
      DOI: 10.1016/j.kint.2021.09.007
       
  • The spatially resolved transcriptional profile of acute T-cell mediated
           rejection in a kidney allograft.

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      Authors: Fadi E. Salem; Laura Perin, Sargis Sedrakyan, Andrea Angeletti, GianMarco Ghiggeri, Maria Cristina Coccia, Marty Ross, Miguel Fribourg, Paolo Cravedi
      Abstract: Analysis of the transcriptional profile of graft biopsies represents a promising strategy to study T cell mediated-rejection (TCMR), also known as acute cellular rejection. However, bulk RNA sequencing of graft biopsies may not capture the focal nature of acute rejection. Herein, we used the whole exome GeoMX Digital Space Profiling platform to study five tubular and three glomerular regions of interest in the kidney graft biopsy from a patient with a chronic-active TCMR episode and in analogous areas from two different normal kidney control biopsies.
      Citation: Kidney International (2021)
      PubDate: 2021-09-20
      DOI: 10.1016/j.kint.2021.09.004
       
  • The SARS-CoV-2 neutralizing capacity of kidney transplant recipients four
           weeks after receiving a second dose of the BNT162b2 vaccine

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      Authors: Rune M. Pedersen; Line L. Bang, Ditte S. Tornby, Helene Kierkegaard, Anna C. Nilsson, Isik S. Johansen, Claus Bistrup, Thøger G. Jensen, Ulrik S. Justesen, Thomas E. Andersen
      Abstract: COVID-19 vaccinated kidney transplant recipients (KTRs) display a lower-than-normal antibody (Ab) response towards SARS-CoV-2, indicating a reduced humoral immune response against the virus [1]. A remaining question is to which extend this translates to lower ability of KTRs to combat SARS-COV-2 [2]. This capacity can be estimated by surrogate or pseudovirus neutralization assays or, optimally, the plaque reduction neutralization test (PRNT) in which live SARS-COV-2 is challenged directly with patient blood plasma [3, 4].
      Citation: Kidney International (2021)
      PubDate: 2021-09-18
      DOI: 10.1016/j.kint.2021.09.006
       
  • Proteinuric chronic kidney disease is associated with altered red blood
           cell lifespan, deformability and metabolism.

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      Authors: Rosi Bissinger; Travis Nemkov, Angelo D´Alessandro, Marijke Grau, Thomas Dietz, Bernhard N. Bohnert, Daniel Essigke, Matthias Wörn, Lina Schaefer, Mengyun Xiao, Jonathan M. Beirne, M. Zaher Kalo, Anja Schork, Tamam Bakchoul, Kingsley Omage, Lingsi Kong, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Birgit Fehrenbacher, Martin Schaller, Achal Dhariwal, Andreas L. Birkenfeld, Florian Grahammer, Syed M. Qadri, Ferruh Artunc
      Abstract: Anemia is a common complication of chronic kidney disease, affecting the quality of life of patients. Among various factors, such as iron and erythropoietin deficiency, reduced red blood cell (RBC) lifespan has been implicated in the pathogenesis of anemia. However, mechanistic data on in vivo RBC dysfunction in kidney disease are lacking. Herein, we describe the development of chronic kidney disease-associated anemia in mice with proteinuric kidney disease resulting from either administration of doxorubicin or an inducible podocin deficiency.
      Citation: Kidney International (2021)
      PubDate: 2021-09-15
      DOI: 10.1016/j.kint.2021.08.024
       
  • The semaphorin 4A–neuropilin 1 axis alleviates kidney ischemia
           reperfusion injury by promoting the stability and function of regulatory T
           cells.

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      Authors: Junnan Xu; Xiubin Li, Qing Yuan, Chenfeng Wang, Liang Xu, Xing Wei, Haitao Liu, Bo Yu, Zhekun An, Yuanyu Zhao, Xiang Li, Xu Zhang, Xin Ma, Ming Cai
      Abstract: Previous studies have suggested the role of CD4+Foxp3+ regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, the associated mechanisms of Tregs in kidney ischemia reperfusion injury have not been fully elucidated. Semaphorin 4A (Sema4A) is essential for maintaining the immunosuppressive capacity of Tregs in tumors. However, whether Sema4A can alleviate kidney ischemia reperfusion injury through Tregs has not yet been demonstrated.
      Citation: Kidney International (2021)
      PubDate: 2021-09-14
      DOI: 10.1016/j.kint.2021.08.023
       
  • Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by
           off-target ferrochelatase inhibition.

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      Authors: Yuntao Bai; Ji Young Kim, Bijay Bisunke, Laura A. Jayne, Josie A. Silvaroli, Michael S. Balzer, Megha Gandhi, Kevin M. Huang, Veronika Sander, Jason Prosek, Rachel E. Cianciolo, Sharyn D. Baker, Alex Sparreboom, Kenar D. Jhaveri, Katalin Susztak, Amandeep Bajwa, Navjot Singh Pabla
      Abstract: A multitude of disease and therapy related factors drive the frequent development of kidney disorders in cancer patients. Along with chemotherapy, the newer targeted therapeutics can also cause kidney dysfunction through on and off-target mechanisms. Interestingly, among the small molecule inhibitors approved for the treatment of cancers that harbor BRAF-kinase activating mutations, vemurafenib can trigger tubular damage and acute kidney injury. BRAF is a proto-oncogene involved in cell growth. To investigate the underlying mechanisms, we developed cell culture and mouse models of vemurafenib kidney toxicity.
      Citation: Kidney International (2021)
      PubDate: 2021-09-14
      DOI: 10.1016/j.kint.2021.08.022
       
  • COVID-19 Vaccination Followed by Activation of Glomerular Diseases Does
           Association Equal Causation'

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      Authors: Nicholas L. Li; P. Toby Coates, Brad H. Rovin
      Abstract: To date over 4 billion doses of the various Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines have been administered worldwide in response to the Coronavirus Disease 2019 (COVID-19) pandemic. Even as widespread vaccination campaigns have contributed to declining case rates, adverse events are appearing beyond those originally reported in the clinical trials of vaccine efficacy and safety. Of particular relevance to the kidney is the increasing number of reports of de novo or reactivation of glomerular diseases (Table 1).
      Citation: Kidney International (2021)
      PubDate: 2021-09-14
      DOI: 10.1016/j.kint.2021.09.002
       
  • OBITUARY FOR CHARLES R KLEEMAN

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      Authors: Gabriel Danovitch; Leon Fine
      Abstract: Chuck’s classic textbook, co-edited with Morton Maxwell, Clinical Disorders of Fluid and Electrolyte Metabolism published first in 1962 and went through six editions. For those of our generation, then entering the new field of nephrology, that book today still reminds of the English romantic poet John Keats’s famous sonnet “On First Looking Into Chapman’s Homer”. Even sixty years later, its chapters on bone and mineral metabolism, and salt and water homeostasis, withstand critical reading. We owe much of our youthful enthusiasm for nephrology to Chuck and his inspired teaching.
      Citation: Kidney International (2021)
      PubDate: 2021-09-10
      DOI: 10.1016/j.kint.2021.08.021
       
  • A third vaccine dose substantially improves humoral and cellular
           SARS-CoV-2 immunity in renal transplant recipients with primary humoral
           non-response

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      Authors: Timm H. Westhoff; Felix S. Seibert, Moritz Anft, Arturo Blazquez-Navarro, Sarah Skrzypczyk, Panagiota Zgoura, Toni L. Meister, Stephanie Pfaender, Julian Stumpf, Christian Hugo, Richard Viebahn, Toralf Roch, Ulrik Stervbo, Nina Babel
      Abstract: Renal transplant recipients (RTR) are at high risk for fatal Coronavirus disease 2019 (COVID-19) [1]. Vaccinations are indispensable to protect this vulnerable population. Unfortunately,>50% of solid organ recipients do not mount antibody responses after two doses of SARS-CoV-2-mRNA vaccines [2,3]. We hypothesized that a third vaccine dose elicits protective humoral and cellular immune response in primary non-responders. Ten RTR under immunosuppression (Suppl. Table 1) without measurable SARS-CoV-2 spike antibodies 4 weeks after a second dose of BNT162b2, received a third vaccine dose (mRNA-1273), which was well tolerated.
      Citation: Kidney International (2021)
      PubDate: 2021-09-09
      DOI: 10.1016/j.kint.2021.09.001
       
  • Impact of rituximab on humoral response to COVID-19 booster vaccine and
           antibody kinetics in patients with ANCA vasculitis

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      Authors: Sam Kant; Duvuru Geetha
      Abstract: The advent of vaccines has resulted in mitigation of severe disease as a consequence of SARS-CoV-2. There is notable absence of humoral absence after two doses of mRNA vaccines in rheumatic and musculoskeletal diseases. 1 There has been evidence that administration of third dose of vaccine leads to augmentation of humoral response in kidney transplant recipients. 2 In addition, there is increasing evidence that neutralizing antibody titers correlate with reduction in breakthrough infections in vaccinated individuals.
      Citation: Kidney International (2021)
      PubDate: 2021-09-06
      DOI: 10.1016/j.kint.2021.08.020
       
  • Risks factors associated with poor response to COVID-19 vaccination in
           kidney transplant recipients

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      Authors: Yorg Azzi; Harith Raees, Tao Wang, Levi Cleare, Luz Liriano-Ward, Pablo Loarte-Campos, Cindy Pynadath, Maria Ajaimy, Omar Alani, Yi Bao, Liise-anne Pirofski, Enver Akalin
      Abstract: The case fatality ratio of COVID-19 in kidney transplant recipients (KTR) is between 10-30%1,2, underscoring the importance of vaccination to prevent COVID-19. However, KTR have a reduced response to COVID-19 vaccines (18%-54%)3,4. We determined SARS-CoV-2 spike IgG (anti-spike IgG) responses to COVID-19 vaccination in 65 KTRs who received BNT162b2, 29 who received mRNA-1273, and 4 who received Janssen Ad26.CoV2.S vaccines at a median of 4 years (range, 3 months-22 years) after transplantation (supplemental table and files).
      Citation: Kidney International (2021)
      PubDate: 2021-09-02
      DOI: 10.1016/j.kint.2021.08.019
       
  • Safety, pharmacodynamics, and exposure-response modeling results from a
           first in human phase 1 study of nedosiran in primary hyperoxaluria.

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      Authors: Bernd Hoppe; Annelize Koch, Pierre Cochat, Sander F. Garrelfs, Michelle A. Baum, Jaap W. Groothoff, Graham Lipkin, Martin Coenen, Gesa Schalk, Aniruddha Amrite, David McDougall, Kelly Barrios, Craig B. Langman
      Abstract: Primary hyperoxaluria (PH) is a family of ultra-rare autosomal recessive inherited disorders of hepatic glyoxylate metabolism characterized by oxalate overproduction. Nedosiran is an RNA interference agent that inhibits hepatic lactate dehydrogenase, the enzyme responsible for the common, final step of oxalate production in all three genetic subtypes of primary hyperoxaluria. Here, we assessed in a two-part, randomized, single-ascending-dose, phase 1 study (PHYOX1) the safety, pharmacokinetics, pharmacodynamics, and exposure-response of subcutaneous nedosiran in 25 healthy participants (Group A) and 18 patients with PH1 or PH2 (Group B).
      Citation: Kidney International (2021)
      PubDate: 2021-09-01
      DOI: 10.1016/j.kint.2021.08.015
       
  • Better Late than Never: Eventual Seroconversion against SARS-CoV-2 in a
           Kidney Transplant Recipient after Repeated Immune Challenge and Monoclonal
           Antibody Therapy.

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      Authors: Julien De Greef; Arnaud Devresse, Imane Saad Albichr, Anais Scohy, Nada Kanaan, Hélène Georgery, Leila Belkhir, Benoit Kabamba, Jean Cyr Yombi, Eric Goffin
      Abstract: Kidney transplant recipients (KTRs) are disproportionately affected by COVID-19. In addition to limited therapeutic options, concerns have arisen regarding poor vaccine efficacy in this population.1
      Citation: Kidney International (2021)
      PubDate: 2021-08-30
      DOI: 10.1016/j.kint.2021.08.018
       
  • A third injection of BNT162b2 mRNA Covid-19 vaccine in kidney transplant
           recipients improves the humoral immune response

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      Authors: Christophe Masset; Clarisse Kerleau, Claire Garandeau, Simon Ville, Diego Cantarovich, Maryvonne Hourmant, Delphine Kervella, Aurélie Meurette, Cécile Guillot-Gueguen, Irène Guihard, Magali Giral, Jacques Dantal, Gilles Blancho
      Abstract: Several reports have highlighted the poor humoral immune response of kidney transplant recipients following Covid mRNA vaccination compared to immunocompetent patients1–3. Therefore, the French National Authority for Health has recommended the use of a third vaccine dose for immunosuppressed patients such as solid organ transplant recipients. We retrospectively assessed the humoral response of all kidney and pancreas transplant recipients vaccinated with BNT162b2 mRNA (Pfizer BioNTech) Covid-19 vaccine between January and May 2021 in our center.
      Citation: Kidney International (2021)
      PubDate: 2021-08-30
      DOI: 10.1016/j.kint.2021.08.017
       
  • ACE2 Decreased Expression During Kidney Inflammatory Diseases:
           Implications to Predisposing to COVID 19 Kidney Complications

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      Authors: Gabriela E. Garcia; Luan D. Truong, Richard J. Johnson
      Abstract: Although ACE2 is the receptor for SARS-CoV-2 entry into target cells, it has a major anti-inflammatory role by hydrolyzing angiotensin II, a pro-inflammatory mediator, to angiotensin 1-7, an anti-inflammatory molecule.
      Citation: Kidney International (2021)
      PubDate: 2021-08-30
      DOI: 10.1016/j.kint.2021.08.016
       
  • The State of the Global Nephrology Workforce: A Joint
           ASN–ERA-EDTA–ISN Investigation

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      Authors: Stephen M. Sozio; Kurtis A. Pivert, Fergus J. Caskey, Adeera Levin, American Society of Nephrology (ASN), European Renal Association—European Dialysis the International Society of Nephrology (ISN)
      Abstract: Chronic kidney disease (CKD) is a global health crisis, affecting 11%–13% of the world’s population.1,2 Although gaps in the workforce and available training pathways have been explored,3,4 it remains unclear if nephrologist availability—measured as ratios of nephrologists to both the general population and to individuals burdened by CKD—is sufficient for the estimated 850 million individuals with CKD. The scope of kidney health services nephrologists provide, qualified by local healthcare environments and practice patterns, may also vary geographically.
      Citation: Kidney International (2021)
      PubDate: 2021-08-30
      DOI: 10.1016/j.kint.2021.07.029
       
  • Anti-SARS-CoV-2 Spike Protein S1 Receptor-Binding Domain Antibody to An
           Inactivated Whole-virus SARS-CoV-2 Vaccination in End-stage Kidney Disease
           Patients: An Initial Report

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      Authors: Sarinya Boongird; Piyatida Chuengsaman, Salinnart Phanprasert, Rungthiwa Kitpermkiat, Montira Assanatham, Arkom Nongnuch, Sasisopin Kiertiburanakul, Kumthorn Malathum, Angsana Phuphuakrat, Chavachol Sethaudom, Jackrapong Bruminhent
      Abstract: Patients with end-stage kidney disease (ESKD) are at greater risk for morbidity and mortality following coronavirus disease 2019 (COVID-19) than the general population.1 Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for this vulnerable population is the main priority to prevent COVID-19 and mitigate unfavorable or severe complications. However, the immune responses to vaccination in ESKD patients may be altered by accumulating of uremic toxins and comorbidities.
      Citation: Kidney International (2021)
      PubDate: 2021-08-19
      DOI: 10.1016/j.kint.2021.08.007
       
  • Membranous nephropathy following anti-Covid-19 mRNA vaccination.

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      Authors: Lorraine Gueguen; Charlotte Loheac, Nadia Saidani, Lydie Khatchatourian
      Abstract: Letter to the editor
      Citation: Kidney International (2021)
      PubDate: 2021-08-19
      DOI: 10.1016/j.kint.2021.08.006
       
  • A multicenter feasibility randomized controlled trial to assess the impact
           of incremental versus conventional initiation of hemodialysis on residual
           kidney function.

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      Authors: Enric Vilar; Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington
      Abstract: Twice-weekly hemodialysis, as part of incremental initiation, has reported benefits including preservation of residual kidney function (RKF). To explore this, we initiated a randomized controlled feasibility trial examining 55 incident hemodialysis patients with urea clearance of 3ml/min/1.73m2 or more across four centers in the United Kingdom randomized to standard or incremental schedules for 12 months. Incremental hemodialysis involved twice weekly sessions, upwardly adjusting hemodialysis dose as RKF was lost maintaining total (Dialysis+Renal) Std Kt/V above 2.
      Citation: Kidney International (2021)
      PubDate: 2021-08-18
      DOI: 10.1016/j.kint.2021.07.025
       
  • A randomized multicenter trial on a lung ultrasound guided treatment
           strategy in patients on chronic hemodialysis with high cardiovascular
           risk.

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      Authors: Carmine Zoccali; Claudia Torino, Francesca Mallamaci, Pantelis Sarafidis, Aikaterini Papagianni, Robert Ekart, Radovan Hojs, Marian Klinger, Krzysztof Letachowicz, Danilo Fliser, Sarah Seiler-Mußler, Fabio Lizzi, Andrzej Wiecek, Agata Miskiewicz, Kostas Siamopoulos, Olga Balafa, Itzchak Slotki, Linda Shavit, Aristeidis Stavroulopoulos, Adrian Covic, Dimitrie Siriopol, Ziad A. Massy, Alexandre Seidowsky, Yuri Battaglia, Alberto Martinez-Castelao, Carolina Polo-Torcal, Marie-Jeanne Coudert-Krier, Patrick Rossignol, Enrico Fiaccadori, Giuseppe Regolisti, Thierry Hannedouche, Thomas Bachelet, Kitty J. Jager, Friedo W. Dekker, Rocco Tripepi, Giovanni Tripepi, Luna Gargani, Rosa Sicari, Eugenio Picano, Gérard Michel London
      Abstract: Lung congestion, estimated by lung ultrasound is a risk factor for all-cause and cardiovascular mortality in patients on chronic hemodialysis and may be useful to guide ultrafiltration and drug therapy in this population. In an international, multi-center randomized controlled trial (NCT02310061) we investigated whether a lung ultrasound-guided treatment strategy improved a composite end point (all-cause death, non-fatal myocardial infarction, decompensated heart failure) vs usual care in patients receiving chronic hemodialysis with high cardiovascular risk.
      Citation: Kidney International (2021)
      PubDate: 2021-08-18
      DOI: 10.1016/j.kint.2021.07.024
       
  • A multi-center retrospective cohort study defines the spectrum of kidney
           pathology in Coronavirus 2019 Disease (COVID-19).

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      Authors: Rebecca M. May; Clarissa Cassol, Andrew Hannoudi, Christopher P. Larsen, Edgar Lerma, Randy S. Haun, Juarez R. Braga, Samar I. Hassen, Jon Wilson, Christine VanBeek, Mahesha Vankalakunti, Lilli Barnum, Patrick D. Walker, T. David Bourne, Nidia C. Messias, Josephine M. Ambruzs, Christie L. Boils, Shree S. Sharma, L. Nicholas Cossey, Pravir V. Baxi, Matthew Palmer, Jonathan Zuckerman, Vighnesh Walavalkar, Anatoly Urisman, Alexander Gallan, Laith F. Al-Rabadi, Roger Rodby, Valerie Luyckx, Gusavo Espino, Srivilliputtur Santhana-Krishnan, Brent Alper, Son G. Lam, Ghadeer N. Hannoudi, Dwight Matthew, Mark Belz, Gary Singer, Srikanth Kunaparaju, Deborah Price, Chawla Sauabh, Chetana Rondla, Mazen A. Abdalla, Marcus L. Britton, Subir Paul, Uday Ranjit, Prasad Bichu, Sean R. Williamson, Yuvraj Sharma, Ariana Gaspert, Phillipp Grosse, Ian Meyer, Brahm Vasudev, Mohamad El Kassem, Juan Carlos Q. Velez, Tiffany N. Caza
      Abstract: Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19) resulting in increased morbidity and mortality. In an international collaboration, 284 kidney biopsies were evaluated to improve understanding of kidney disease in COVID-19. Diagnoses were compared to five years of 63,575 native biopsies prior to the pandemic and 13,955 allograft biopsies to identify diseases increased in patients with COVID-19. Genotyping for APOL1 G1 and G2 alleles was performed in 107 African American and Hispanic patients.
      Citation: Kidney International (2021)
      PubDate: 2021-08-02
      DOI: 10.1016/j.kint.2021.07.015
       
  • Iron status, fibroblast growth factor 23 and cardiovascular and kidney
           outcomes in chronic kidney disease.

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      Authors: Rupal Mehta; Monique E. Cho, Xuan Cai, Jungwha Lee, Jing Chen, Jiang He, John Flack, Tariq Shafi, Santosh L. Saraf, Valentin David, Harold I. Feldman, Tamara Isakova, Myles Wolf, CRIC Study Investigators
      Abstract: Disordered iron and mineral homeostasis are interrelated complications of chronic kidney disease that may influence cardiovascular and kidney outcomes. In a prospective analysis of 3747 participants in the Chronic Renal Insufficiency Cohort Study, we investigated risks of mortality, heart failure, end-stage kidney disease (ESKD), and atherosclerotic cardiovascular disease according to iron status, and tested for mediation by C-terminal fibroblast growth factor 23 (FGF23), hemoglobin and parathyroid hormone.
      Citation: Kidney International (2021)
      PubDate: 2021-08-02
      DOI: 10.1016/j.kint.2021.07.013
       
  • A Mendelian randomization study found causal linkage between telomere
           attrition and chronic kidney disease

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      Authors: Sehoon Park; Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
      Abstract: Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is rarely investigated whether kidney function is causally linked to biological aging itself. In this Mendelian randomization study, genetic instruments for telomere attrition were applied to a CKDGen genome wide association study results for 41,395 cases of CKD among 480,698 individuals as summary-level Mendelian randomization. A replicative analysis was performed by polygenic score analysis using independent United Kingdom Biobank data for 8,118 cases of CKD among 321,024 white individuals of British ancestry.
      Citation: Kidney International (2021)
      PubDate: 2021-08-02
      DOI: 10.1016/j.kint.2021.06.041
       
  • The circadian clock regulates rhythmic erythropoietin expression in the
           murine kidney

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      Authors: Lina K. Sciesielski; Matthias Felten, Laura Michalick, Karin M. Kirschner, Georgia Lattanzi, Charlotte LJ. Jacobi, Thomas Wallach, Veronika Lang, Dominic Landgraf, Achim Kramer, Christof Dame
      Abstract: Generation of circadian rhythms is cell-autonomous and relies on a transcription/translation feedback loop controlled by a family of circadian clock transcription factor activators including CLOCK, BMAL1 and repressors such as CRY1 and CRY2. The aim of the present study was to examine both the molecular mechanism and the hemopoietic implication of circadian erythropoietin expression. Mutant mice with homozygous deletion of the core circadian clock genes cryptochromes 1 and 2 (Cry-null) were used to elucidate circadian erythropoietin regulation.
      Citation: Kidney International (2021)
      PubDate: 2021-07-29
      DOI: 10.1016/j.kint.2021.07.012
       
  • A mathematical estimation of the physical forces driving podocyte
           detachment

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      Authors: Linus Butt; David Unnersjö-Jess, Martin Höhne, Bernhard Schermer, Aurelie Edwards, Thomas Benzing
      Abstract: Loss of podocytes, possibly through the detachment of viable cells, is a hallmark of progressive glomerular disease. Podocytes are exposed to considerable physical forces due to pressure and flow resulting in circumferential wall stress and tangential shear stress exerted on the podocyte cell body, which have been proposed to contribute to podocyte depletion. However, estimations of in vivo alterations of physical forces in glomerular disease have been hampered by a lack of quantitative functional and morphological data.
      Citation: Kidney International (2021)
      PubDate: 2021-07-29
      DOI: 10.1016/j.kint.2021.06.040
       
  • Vitamin K and cardiovascular complications in CKD patients

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      Authors: N. Kaesler; L.J. Schurgers, J. Floege
      Abstract: Vitamin K, well known for its role in coagulation, encompasses two major subgroups: Vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme γ-glutamyl carboxylase, which carboxylates and thereby activates various vitamin K dependent proteins. Several vitamin K–dependent proteins are synthesized in bone but the role of vitamin K for bone health in CKD patients, in particular the prevention of osteoporosis is still not firmly established.
      Citation: Kidney International (2021)
      PubDate: 2021-07-23
      DOI: 10.1016/j.kint.2021.06.037
       
  • Chronic Kidney Disease Rescuing kidney patients from early demise: Role of
           anti-cytokine therapies

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      Authors: T. Alp Ikizler; Jonathan Himmelfarb
      Abstract: Biomarkers of the inflammatory state are elevated in individuals with chronic kidney disease (CKD) and are also robust predictors of cardiovascular disease (CVD) and mortality in this population. In addition to its predictive ability, inflammation has been implicated in the pathogenesis of atherosclerotic CVD, primarily through NLRP3 inflammasome and interleukin-1 (IL-1) and interleukin-6 (IL-6) signaling pathways 1. Based on these data, it has been suggested that ameliorating the inflammatory response through anti-cytokine therapies could improve CVD risk factors and potentially survival in CKD.
      Citation: Kidney International (2021)
      PubDate: 2021-07-21
      DOI: 10.1016/j.kint.2021.07.011
       
  • Skimming the fat in diabetic kidney disease: KIM-1 and tubular fatty acid
           uptake

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      Authors: Huihui Huang; Samir M. Parikh
      Abstract: Diabetic kidney disease (DKD) accounts for over 40% of incident ESKD cases. The clinical hallmarks of DKD include reduced glomerular filtration rate (GFR) and increased urinary albumin excretion. Although DKD is traditionally considered a glomerular disease, tubulointerstitial injury is recognized as an important predictor of chronic kidney disease progression in diabetes. Tubular atrophy and interstitial fibrosis are strongly correlated with the progression of diabetic nephropathy to ESKD. Further supporting the role of tubules in DKD progression, the sodium/glucose cotransporter 2 (SGLT2) expressed in proximal tubules has emerged as a major therapeutic target for DKD.
      Citation: Kidney International (2021)
      PubDate: 2021-07-20
      DOI: 10.1016/j.kint.2021.06.038
       
  • How cyclosporin reduces mycophenolic acid exposure by 40% while other
           calcineurin inhibitors do not.

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      Authors: Teun van Gelder
      Abstract: The most frequently used immunosuppressive treatment in kidney transplant recipients is the combination therapy of a calcineurin inhibitor and mycophenolate mofetil (MMF), with or without corticosteroids. Cyclosporin and tacrolimus are the two calcineurin inhibitors registered for this indication.Also in the treatment of glomerular diseases calcineurin inhibitors and mycophenolic acid are being used on a worldwide scale, either alone or as combined treatment. In January 2021 the U.S. Food and Drug Administration (FDA) has approved voclosporin, a novel calcineurin inhibitor for the treatment of adult patients with active lupus nephritis.
      Citation: Kidney International (2021)
      PubDate: 2021-07-17
      DOI: 10.1016/j.kint.2021.06.036
       
  • A Team-Based Approach for Testing Biomarkers of Kidney Disease Progression

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      Authors: Javier A. Neyra
      Abstract: Acute kidney injury (AKI) is an important public health concern given its high incidence, paucity of effective therapies, and strong association with mortality. Survivors of hospitalized AKI are at increased risk of cardiovascular disease, de novo chronic kidney disease (CKD), and progression of prevalent CKD. Therefore, risk-classification is critical to guide surveillance and interventions after AKI. Specialized post-discharge care focused on high-risk AKI survivors has been implemented in multiple centers, and interventions to improve clinical and patient-centered outcomes are being investigated.
      Citation: Kidney International (2021)
      PubDate: 2021-07-16
      DOI: 10.1016/j.kint.2021.06.035
       
  • The ketone body β-hydroxybutyrate mitigates the senescence response of
           glomerular podocytes to diabetic insults.

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      Authors: Yudong Fang; Bohan Chen, Athena Y. Gong, Deepak Malhotra, Rajesh Gupta, Lance D. Dworkin, Rujun Gong
      Abstract: Diabetic kidney disease (DKD) is one of the most common complications of diabetes and clinically featured by progressive albuminuria, consequent to glomerular destruction that involves podocyte senescence. Burgeoning evidence suggests that ketosis, in particular β-hydroxybutyrate, exerts a beneficial effect on aging and on myriad metabolic or chronic diseases, including obesity, diabetes and chronic kidney diseases. Its effect on DKD is largely unknown. In vitro in podocytes exposed to a diabetic milieu, β-hydroxybutyrate treatment substantially mitigated cellular senescence and injury, as evidenced by reduced formation of γH2AX foci, reduced staining for senescence-associated-β-galactosidase activity, diminished expression of key mediators of senescence signaling like p16INK4A and p21, and preserved expression of synaptopodin.
      Citation: Kidney International (2021)
      PubDate: 2021-07-08
      DOI: 10.1016/j.kint.2021.06.031
       
  • Significance of HLA-DQ in kidney transplantation - Time to re-evaluate HLA
           matching priorities to improve transplant outcomes' An expert review
           and recommendations

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      Authors: Anat R. Tambur; Vasilis Kosmoliaptsis, Frans HJ. Claas, Roslyn B. Mannon, Peter Nickerson, Maarten Naesens
      Abstract: The weight of HLA matching in kidney allocation algorithms, especially in the US, has been devalued in a stepwise fashion, supported by the introduction of modern immunosuppression. The intent was further to reduce the observed ethnic/racial disparity, as data emerged associating HLA matching with decreased access to transplantation for African American patients. In recent years, it has been increasingly recognized that a leading cause of graft loss is chronic antibody mediated rejection attributed to the development of de novo antibodies against mismatched donor HLA expressed on the graft.
      Citation: Kidney International (2021)
      PubDate: 2021-07-07
      DOI: 10.1016/j.kint.2021.06.026
       
  • A Review of kidney transplantation from HCV-Viremic Donors into Negative
           Recipients

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      Authors: Reem Daloul; Todd Pesavento, David S. Goldberg, Peter P. Reese
      Abstract: The safety and efficacy of direct acting antiviral therapies have allowed the transplantation of organs from hepatitis C virus (HCV)-viremic donors into uninfected recipients. This novel strategy contrasts with the previous standard-of-care practice of limiting the transplantation of HCV infected donor organs to HCV infected recipients, or all too often, discarding viable organs. In this review, we summarize the published literature about the safety and feasibility of transplanting organs from HCV-viremic donors, the challenges that hinder wider adoption of this strategy, and future research needs.
      Citation: Kidney International (2021)
      PubDate: 2021-07-05
      DOI: 10.1016/j.kint.2021.06.034
       
  • Measurement of urinary Dickkopf-3 uncovered silent progressive kidney
           injury in patients with chronic obstructive pulmonary disease.

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      Authors: Stefan J. Schunk; Christoph Beisswenger, Felix Ritzmann, Christian Herr, Martina Wagner, Sarah Triem, Gregor Hütter, David Schmit, Stephen Zewinger, Tamim Sarakpi, Anja Honecker, Peer Mahadevan, Peter Boor, Stefan Wagenpfeil, Rudolf Jörres, Henrik Watz, Tobias Welte, Claus F. Vogelmeier, Hermann-Josef Gröne, Danilo Fliser, Thimoteus Speer, Robert Bals
      Abstract: Chronic kidney disease (CKD) represents a global public health problem with high disease related morbidity and mortality. Since CKD etiology is heterogeneous, early recognition of patients at risk for progressive kidney injury is important. Here, we evaluated the tubular epithelial derived glycoprotein dickkopf-3 (DKK3) as a urinary marker for the identification of progressive kidney injury in a non-CKD cohort of patients with chronic obstructive pulmonary disease (COPD) and in an experimental model.
      Citation: Kidney International (2021)
      PubDate: 2021-07-05
      DOI: 10.1016/j.kint.2021.06.029
       
  • An international cohort study spanning five decades assessed outcomes of
           nephropathic cystinosis.

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      Authors: Francesco Emma; William van’t Hoff, Katharina Hohenfellner, Rezan Topaloglu, Marcella Greco, Gema Ariceta, Chiara Bettini, Detlef Bockenhauer, Koenraad Veys, Lars Pape, Sally Hulton, Suzanne Collin, Fatih Ozaltin, Aude Servais, Georges Deschênes, Robert Novo, Aurélia Bertholet-Thomas, Jun Oh, Elisabeth Cornelissen, Mirian Janssen, Dieter Haffner, Lucilla Ravà, Corinne Antignac, Olivier Devuyst, Patrick Niaudet, Elena Levtchenko
      Abstract: Nephropathic cystinosis is a rare disease secondary to recessive mutations of the CTNS gene encoding the lysosomal cystine transporter cystinosin, causing accumulation of cystine in multiple organs. Over the years, the disease has evolved from being a fatal condition during early childhood into a treatable condition, with patients surviving into adulthood. Data on cystinosis are limited by the rarity of the disease. Here, we have investigated factors associated with kidney and growth outcome in a very large cohort of 453 patients born between 1964 and 2016 and followed in Belgium, Germany, Austria, France, Italy, Spain, The Netherlands, Turkey and United Kingdom.
      Citation: Kidney International (2021)
      PubDate: 2021-07-05
      DOI: 10.1016/j.kint.2021.06.019
       
  • Recent advances in lineage tracing for the kidney

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      Authors: Yoshiharu Muto; Benjamin D. Humphreys
      Abstract: Lineage tracing was originally developed by developmental biologists to identify all progeny of a single cell during morphogenesis. More recently this approach has been applied to other fields, including organ homeostasis and recovery from injury. Modern lineage tracing techniques typically rely on reporter gene expression induced by cell-specific DNA recombination. There have been important scientific advances in the last ten years that have impacted lineage tracing approaches, including intersectional genetics, optical clearing techniques and the use of sequencing-based genomic lineage tracing.
      Citation: Kidney International (2021)
      PubDate: 2021-07-01
      DOI: 10.1016/j.kint.2021.05.040
       
  • A genome-wide association study suggests correlations of common genetic
           variants with peritoneal solute transfer rates in patients with kidney
           failure receiving peritoneal dialysis.

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      Authors: Rajnish Mehrotra; Ian B. Stanaway, Gail P. Jarvik, Mark Lambie, Johann Morelle, Jeffrey Perl, Jonathan Himmelfarb, Olof Heimburger, David W. Johnson, Talha H. Imam, Bruce Robinson, Peter Stenvinkel, Olivier Devuyst, Simon J. Davies, the Bio-PD Consortium
      Abstract: Movement of solutes across the peritoneum allows for the use of peritoneal dialysis to treat kidney failure. However, there is a large inter-individual variability in the peritoneal solute transfer rate (PSTR). Here, we tested the hypothesis that common genetic variants are associated with variability in PSTR. Of the 3561 participants from 69 centers in six countries, 2850 with complete data were included in a genome-wide association study. PSTR was defined as the four-hour dialysate/plasma creatinine ratio from the first peritoneal equilibration test after starting PD.
      Citation: Kidney International (2021)
      PubDate: 2021-06-28
      DOI: 10.1016/j.kint.2021.05.037
       
  • NPHP1 gene-associated nephronophthisis is associated with an occult
           retinopathy

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      Authors: Johannes Birtel; Georg Spital, Marius Book, Sandra Habbig, Sören Bäumner, Vera Riehmer, Bodo B. Beck, David Rosenkranz, Hanno J. Bolz, Mareike Dahmer-Heath, Philipp Herrmann, Jens König, Peter Charbel Issa
      Abstract: Biallelic deletions in the NPHP1 gene are the most frequent molecular defect of nephronophthisis, a kidney ciliopathy and leading cause of hereditary end-stage kidney disease. Nephrocystin 1, the gene product of NPHP1, is also expressed in photoreceptors where it plays an important role in intra-flagellar transport between the inner and outer segments. However, the human retinal phenotype has never been investigated in detail. Here, we characterized retinal features of 16 patients with homozygous deletions of the entire NPHP1 gene.
      Citation: Kidney International (2021)
      PubDate: 2021-06-18
      DOI: 10.1016/j.kint.2021.06.012
       
  • Running Interference: Lumasiran and other RNA interference therapeutics
           for kidney diseases

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      Authors: Ziad A. Massy; Tilman B. Drueke
      Abstract: RNA interference (RNAi) is a biological process which directly modulates gene activity. RNAi-based therapeutic agents, which bind specifically to target messenger RNA (mRNA) sequences, allow downstream silencing of the respective target protein. In recent years, RNAi-based agents have become a major novel tool for the treatment of several rare diseases. In 2018, the first RNAi drug approved by the FDA in the US was patisiran for hereditary transthyretin (TTR) amyloidosis, followed by the approval of givosiran for acute hepatic porphyria, and lumasiran for primary hyperoxaluria (1).
      Citation: Kidney International (2021)
      PubDate: 2021-06-05
      DOI: 10.1016/j.kint.2021.05.027
       
  • Basic Principles and New Advances in Kidney Imaging

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      Authors: Anna Caroli; Andrea Remuzzi, Lilach O. Lerman
      Abstract: Over the past few years, clinical renal imaging has seen great advances, allowing assessments of kidney structure and morphology, perfusion, function and metabolism, oxygenation, as well as microstructure and interstitium. Medical imaging is becoming increasingly important in the evaluation of kidney physiology and pathophysiology, showing promise in management of patients with renal disease, in particular with regard to diagnosis, classification, and prediction of disease development and progression, monitoring response to therapy, detection of drug toxicity, and patient selection for clinical trials.
      Citation: Kidney International (2021)
      PubDate: 2021-05-10
      DOI: 10.1016/j.kint.2021.04.032
       
 
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