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Development
Journal Prestige (SJR): 4.698
Citation Impact (citeScore): 6
Number of Followers: 33  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0950-1991 - ISSN (Online) 1477-9129
Published by Company of Biologists, The Homepage  [5 journals]
  • Controlling traffic at cell junctions

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      PubDate: Thu, 14 Oct 2021 00:00:00 GMT
      Issue No: Vol. 148, No. 20 (2021)
       
  • Reduction of cortical parvalbumin-expressing GABAergic interneurons in a
           rodent hyperoxia model of preterm birth brain injury with deficits in
           social behavior and cognition

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      Authors: Scheuer T; dem Brinke E, Grosser S, et al.
      Abstract: ABSTRACTThe inhibitory GABAergic system in the brain is involved in the etiology of various psychiatric problems, including autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD) and others. These disorders are influenced not only by genetic but also by environmental factors, such as preterm birth, although the underlying mechanisms are not known. In a translational hyperoxia model, exposing mice pups at P5 to 80% oxygen for 48 h to mimic a steep rise of oxygen exposure caused by preterm birth from in utero into room air, we documented a persistent reduction of cortical mature parvalbumin-expressing interneurons until adulthood. Developmental delay of cortical myelin was observed, together with decreased expression of oligodendroglial glial cell-derived neurotrophic factor (GDNF), a factor involved in interneuronal development. Electrophysiological and morphological properties of remaining interneurons were unaffected. Behavioral deficits were observed for social interaction, learning and attention. These results demonstrate that neonatal oxidative stress can lead to decreased interneuron density and to psychiatric symptoms. The obtained cortical myelin deficit and decreased oligodendroglial GDNF expression indicate that an impaired oligodendroglial-interneuronal interplay contributes to interneuronal damage.
      PubDate: Thu, 14 Oct 2021 00:00:00 GMT
      DOI: 10.1242/dev.198390
      Issue No: Vol. 148, No. 20 (2021)
       
  • RASSF8-mediated transport of Echinoid via the exocyst promotes Drosophila
           wing elongation and epithelial ordering

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      Authors: Chan EY; Zhou Y, Aerne BL, et al.
      Abstract: ABSTRACTCell-cell junctions are dynamic structures that maintain cell cohesion and shape in epithelial tissues. During development, junctions undergo extensive rearrangements to drive the epithelial remodelling required for morphogenesis. This is particularly evident during axis elongation, where neighbour exchanges, cell-cell rearrangements and oriented cell divisions lead to large-scale alterations in tissue shape. Polarised vesicle trafficking of junctional components by the exocyst complex has been proposed to promote junctional rearrangements during epithelial remodelling, but the receptors that allow exocyst docking to the target membranes remain poorly understood. Here, we show that the adherens junction component Ras Association domain family 8 (RASSF8) is required for the epithelial re-ordering that occurs during Drosophila pupal wing proximo-distal elongation. We identify the exocyst component Sec15 as a RASSF8 interactor. Loss of RASSF8 elicits cytoplasmic accumulation of Sec15 and Rab11-containing vesicles. These vesicles also contain the nectin-like homophilic adhesion molecule Echinoid, the depletion of which phenocopies the wing elongation and epithelial packing defects observed in RASSF8 mutants. Thus, our results suggest that RASSF8 promotes exocyst-dependent docking of Echinoid-containing vesicles during morphogenesis.
      PubDate: Thu, 14 Oct 2021 00:00:00 GMT
      DOI: 10.1242/dev.199731
      Issue No: Vol. 148, No. 20 (2021)
       
  • Developmental Twists: Only Human

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      Authors: Mogami T.
      PubDate: Thu, 14 Oct 2021 00:00:00 GMT
      DOI: 10.1242/dev.200204
      Issue No: Vol. 148, No. 20 (2021)
       
 
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