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Nature Reviews Cancer
Journal Prestige (SJR): 23.53
Citation Impact (citeScore): 19
Number of Followers: 272  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1474-175X - ISSN (Online) 1474-1768
Published by NPG Homepage  [143 journals]
  • Targeting transcription cycles in cancer

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      Nature Reviews Cancer, Published online: 21 October 2021; doi:10.1038/s41568-021-00411-8

      This Review discusses the concept of transcription cycles in cancer, providing a framework for our understanding of dysregulated transcription in cancer and therapeutic targeting of dysregulated transcription cycles.Nature Reviews Cancer, Published online: 2021-10-21; doi:10.1038/s41568-021-00411-82021-10-21
      DOI: 10.1038/s41568-021-00411-8
       
  • Overcoming TGFβ-mediated immune evasion in cancer

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      Nature Reviews Cancer, Published online: 20 October 2021; doi:10.1038/s41568-021-00413-6

      This Review discusses the context-dependent functions of transforming growth factor-β (TGFβ) with regard to the composition and behaviour of different cell populations in the tumour immune microenvironment, as well as emerging data that demonstrate that TGFβ inhibition can restore cancer immunity.Nature Reviews Cancer, Published online: 2021-10-20; doi:10.1038/s41568-021-00413-62021-10-20
      DOI: 10.1038/s41568-021-00413-6
       
  • Harnessing multimodal data integration to advance precision oncology

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      Nature Reviews Cancer, Published online: 18 October 2021; doi:10.1038/s41568-021-00408-3

      This Perspective proposes that data from multiple modalities, including molecular diagnostics, radiological and histological imaging and codified clinical data, should be integrated by multimodal machine learning models to advance the prognosis and treatment management of patients with cancer.Nature Reviews Cancer, Published online: 2021-10-18; doi:10.1038/s41568-021-00408-32021-10-18
      DOI: 10.1038/s41568-021-00408-3
       
  • The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs

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      Nature Reviews Cancer, Published online: 18 October 2021; doi:10.1038/s41568-021-00407-4

      BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the challenges arising from their implementation in the clinic, such as resistance or on-target toxic effects, and the approaches that could be harnessed to overcome these obstacles.Nature Reviews Cancer, Published online: 2021-10-18; doi:10.1038/s41568-021-00407-42021-10-18
      DOI: 10.1038/s41568-021-00407-4
       
  • New targets in triple-negative breast cancer

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      Nature Reviews Cancer, Published online: 07 October 2021; doi:10.1038/s41568-021-00415-4

      In this Journal Club, Robert L. Copeland and Yasmine Kanaan discuss a paper that reports how ERβ and IGF2 signalling may contribute to the heterogeneity of triple-negative breast cancer observed in patients with different ancestries in the USA.Nature Reviews Cancer, Published online: 2021-10-07; doi:10.1038/s41568-021-00415-42021-10-07
      DOI: 10.1038/s41568-021-00415-4
       
  • Under pressure

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      Nature Reviews Cancer, Published online: 05 October 2021; doi:10.1038/s41568-021-00416-3

      Two recent studies have found that both the adaptive immune system and inflammation can drive the selection of cells carrying mutations that facilitate tumour initiation.Nature Reviews Cancer, Published online: 2021-10-05; doi:10.1038/s41568-021-00416-32021-10-05
      DOI: 10.1038/s41568-021-00416-3
       
  • Bringing community to our pages

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      Nature Reviews Cancer, Published online: 05 October 2021; doi:10.1038/s41568-021-00414-5

      In an effort to bring to our pages some of the vibrant discussion of cancer research that happens during in-person or online journal club meetings, we are now publishing Journal Clubs — an article type in which researchers discuss research papers of their choice with the intention of alerting our readers to articles that have a special significance to them and the field.Nature Reviews Cancer, Published online: 2021-10-05; doi:10.1038/s41568-021-00414-52021-10-05
      DOI: 10.1038/s41568-021-00414-5
       
  • Evolving cancer–niche interactions and therapeutic targets during
           bone metastasis

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      Nature Reviews Cancer, Published online: 05 October 2021; doi:10.1038/s41568-021-00406-5

      This Review discusses the bone microenvironment and its impact on bone metastasis, defining a roadmap of the cancer cell journey through bone relative to various microenvironment components and in different cancer types as well as providing insight into new therapeutic targets.Nature Reviews Cancer, Published online: 2021-10-05; doi:10.1038/s41568-021-00406-52021-10-05
      DOI: 10.1038/s41568-021-00406-5
       
 
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