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  Subjects -> ELECTRONICS (Total: 207 journals)
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Journal of Nuclear Cardiology
Journal Prestige (SJR): 0.796
Citation Impact (citeScore): 2
Number of Followers: 2  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1071-3581 - ISSN (Online) 1532-6551
Published by Springer-Verlag Homepage  [2469 journals]
  • Unfolding the cardioprotective potential of sigma-1 receptor-directed
           molecular imaging

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      PubDate: 2022-08-04
       
  • Influence of image reconstruction on quantitative cardiac 15O-water
           positron emission tomography

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      Abstract: Background The impact on quantitative 15O-water PET/CT of a wide range of different reconstruction settings, including regularized reconstruction by block-sequential regularized expectation maximization (BSREM), was investigated. Methods Twenty clinical stress scans from patients referred for assessment of myocardial ischemia were included. Patients underwent a 4-min dynamic stress PET scan with 15O-water on a digital PET/CT scanner. Twenty-two reconstructions were generated from each scan and a clinical reconstruction was used as reference. Varied parameters were number of iterations, filter, exclusion of time-of-flight and point-spread function, and regularization parameter with BSREM. Analyses were performed in aQuant utilizing two different methods and resulting regional myocardial blood flow (MBF), perfusable tissue fraction (PTF), and transmural MBF (MBFt) values were evaluated. Results Across the two analyses, correlations toward the reference reconstruction were strong for all parameters (ρ ≥ 0.83). Using automated analysis and the diagnostic threshold of hyperemic MBF at 2.3 mL⋅g−1⋅min−1, diagnosis was unchanged irrespective of reconstruction method in all patients except for one, where only four of the most extreme reconstruction methods resulted in a change of diagnosis. Conclusion The low sensitivity of MBF values to reconstruction method and, as previously shown, scanner type and PET/CT misalignment, confirms that diagnostic hyperemic MBF cutoff values can be consistently used for 15O-water.
      PubDate: 2022-08-04
       
  • Abstracts of Original Contributions ASNC2022 The 27th Annual Scientific
           Session of the American Society of Nuclear Cardiology

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      PubDate: 2022-08-04
       
  • Pulmonary artery imaging with 68¬†Ga-FAPI-04 in patients with chronic
           thromboembolic pulmonary hypertension

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      Abstract: Background The feasibility and significance of imaging pulmonary artery (PA) remodeling with 68 Ga-fibroblast activating protein inhibitor (FAPI) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) have not yet been addressed. Methods 68 Ga-FAPI uptake in the PA and ascending artery was evaluated in 13 patients with CTEPH and 13 matched non-CTEPH controls. The correlations of PA 68 Ga-FAPI uptake and remodeling parameters derived from right heart catheterization (RHC) were analyzed. Results Of the 13 patients with CTEPH, nine (69%) showed visually enhanced 68 Ga-FAPI-04 uptake, whereas none of the control subjects had increased 68 Ga-FAPI-04 uptake in the PA. The prevalence of enhanced uptake in the main, lobar, and segmental PAs was 45% (17/38), 33% (16/48), and 28% (44/159), respectively. 68 Ga-FAPI-04 activity in the PA was positively correlated with pulmonary arterial diastolic pressure (r = 0.571, P = 0.041). Conclusion 68 Ga-FAPI-04 has the potential for imaging fibroblast activation in the PA wall, and 68 Ga-FAPI-04 activity in PA is positively correlated with pulmonary arterial diastolic pressure. Graphical abstract
      PubDate: 2022-08-04
       
  • Strengths and weaknesses of alternative noninvasive imaging approaches for
           microvascular ischemia

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      Abstract: Abstract Structural and functional abnormalities of coronary microvasculature are highly prevalent in several clinical settings and often associated with worse clinical outcomes. Therefore, there is a growing interest in the detection and treatment of this, often overlooked, disease. Coronary angiography allows the assessment of the Coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). However, the measurement of these parameters is not always feasible because of limited technical availability and the need for a cardiac catheterization with a small but real risk of potential complications. Recent advances in non-invasive imaging techniques allow the assessment of coronary microvascular function with good accuracy and reproducibility. The objective of this review is to discuss the strengths and weaknesses of alternative non-invasive approaches used in the diagnosis of coronary microvascular dysfunction (CMD), highlighting the most recent advances for each imaging modality.
      PubDate: 2022-08-02
       
  • Prognostic value of combined coronary angiography-derived IMR and
           myocardial perfusion imaging by CZT SPECT in INOCA

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      Abstract: Background A significant proportion of ischemia with non-obstructive coronary artery disease (INOCA) demonstrate coronary microvascular dysfunction (CMD), a condition associated with abnormal myocardial perfusion imaging (MPI) and adverse outcomes. Coronary angiography-derived index of microvascular resistance (caIMR) is a novel non-invasive technique to assess CMD. We aimed to investigate the prognostic value of combined caIMR and MPI by CZT SPECT in INOCA patients. Methods Consecutive 151 patients with chest pain and < 50% coronary stenosis who underwent coronary angiography and MPI within 3 months were enrolled. caIMR was calculated by computational pressure-flow dynamics. CMD was defined as caIMR ≥ 25. The endpoint was major adverse cardiac events (MACE: cardiovascular death, nonfatal myocardial infarction, revascularization, angina-related rehospitalization, heart failure, and stroke). Results Of all INOCA patients, CMD was present in 93 (61.6%) patients. The prevalence of abnormal MPI was significantly higher in CMD compared with non-CMD patients (40.9% vs 13.8%, P < .001). CMD showed a higher risk of MACE than non-CMD patients. Patients with both CMD and abnormal MPI had the worst prognosis, followed by patients with CMD and normal MPI (log-rank P < .001). Cox regression analysis identified CMD (HR 3.121, 95%CI 1.221-7.974, P = .017) and MPI (HR 2.704, 95%CI 1.030-7.099, P = .043) as predictive of MACE. The prognostic value of INOCA patients enhanced significantly by adding CMD and MPI to the model with clinical risk factors (AUC = 0.777 vs 0.686, P = .030). Conclusion caIMR-derived CMD is associated with increased risk of MACE among INOCA patients. Patients with abnormalities on both caIMR and MPI had the worse outcomes. Graphical abstract
      PubDate: 2022-08-02
       
  • Effective suppression of myocardial glucose uptake using predesigned
           low-carbohydrate boxed meals

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      Abstract: Background Dietary preparation protocols are an effective means to suppress physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake. This study aimed to investigate the efficacy of various carbohydrate-restricted diets using predesigned boxed meals. Methods The patients were divided into four groups to undergo different preparatory protocols as follows: a minimum 15-hours fast alone, two meals of high-fat, low-carbohydrate diet (HFLCD), two meals of high-animal-protein, low-carbohydrate diet (HAPLCD), and two meals of high-plant-based-protein, low-carbohydrate diet (HPPLCD). Boxed meals were prepared to meet the required carbohydrate restrictions. Myocardial SUVmax and SUVmean were measured and the suppression rate was analyzed. Results The average myocardial SUVmax of fast alone, HFLCD, HAPLCD, and HPPLCD was 8.26 ± 5.85, 2.21 ± 1.50, 2.34 ± 1.88, and 4.10 ± 3.61, respectively, and the suppression rate was 36.6%, 93.3%, 93.3%, and 70%, respectively. The effectiveness of HFLCD, HAPLCD, and HPPLCD was all statistically superior to that of a 15-hours fast alone. SUVmax of HFLCD and HAPLCD showed no significant differences (p = 1), whereas HFLCD and HPPLCD had significant differences (p = .046). Conclusions Using the predesigned boxed meals based on carbohydrate restriction, HFLCD, HAPLCD, and HPPLCD can be administered to patients with different dietary needs, while providing a substantial reduction in physiological myocardial FDG uptake.
      PubDate: 2022-08-02
       
  • Apical defect following Tendyne valve placement

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      PubDate: 2022-08-01
       
  • Theme papers

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      PubDate: 2022-08-01
       
  • The diagnostic value of FDG PET/CT in Takayasu arteritis

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      PubDate: 2022-08-01
       
  • 18F-FDG PET/CT detected mediastinal small-cell neuroendocrine carcinoma
           with all cardiac cavities metastases

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      PubDate: 2022-08-01
       
  • What is This Image' 2022: Image 2

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      PubDate: 2022-08-01
       
  • JNC awards

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      PubDate: 2022-08-01
       
  • Reducing the effect of proton pump inhibitors augmenting gastrointestinal
           sestamibi uptake

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      PubDate: 2022-08-01
       
  • Go with the flow: Abnormal extra-cardiac Rb-82 flow as a diagnostic clue
           for subclavian vein stenosis

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      PubDate: 2022-08-01
       
  • Comparable image interpretation of 1- and 3-hour technetium-99m HDP
           scintigraphy for transthyretin cardiac amyloidosis

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      PubDate: 2022-08-01
       
  • Dynamic CZT-SPECT in coronary artery disease: Where are we now'

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      PubDate: 2022-08-01
       
  • Beyond perfusion imaging

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      PubDate: 2022-08-01
       
  • Multimodal imaging in hepatocellular carcinoma with inferior vena cava and
           right atrial tumor thrombus

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      PubDate: 2022-08-01
       
  • Left ventricular mechanical dyssynchrony in patients with heart failure:
           What is the next step'

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      PubDate: 2022-08-01
       
 
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