 Subjects -> ANTHROPOLOGY (Total: 398 journals)
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- Heinrich Ewald Hering’s discovery of the heart pacemaker: Hering, Tawara
and Aschoff’s search for its morphological basis, the sinoatrial node,
and why they failed-
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Abstract: Abstract Two groups of investigators investigated the heart pacemaker and its morphological basis in the early twentieth century. The first group was formed by Henrich Ewald Hering (physiologist), Sunao Tawara and Ludwig Aschoff (morphologists). The second group was composed of James Mackenzie (general practitioner and clinical investigator), Arthur Keith and Martin Flack (morphologists). These groups were formed almost at the same time in 1903. Their work resulted in the discovery of the atrioventricular node and Purkinje network (Sunao Tawara, in 1906), heart pacemaker (H E Hering, in 1907) and sinoatrial node (Keith and Flack, in 1907). Here, it is shown how the interconnections of the concurrent works of these groups resulted in the discovery not only of the function, but also of the structure of the sinoatrial node.
PubDate: 2023-03-22
- Changes in the volumes and asymmetry of subcortical structures in healthy
individuals according to gender-
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Abstract: Abstract In recent years, with the development of technology, three-dimensional software has entered our lives. Volumetric measurements made with Magnetic Resonance Imaging (MRI) are essential in the morphometry of the brain and subcortical structures. In this study, we aim to share the volume and asymmetry of the hippocampus, its sub-branches, and other subcortical structures and their interaction with age/sex using volBrain, a web-based automated software. 1.5 T T1-weighted volumetric MRI, of 90 healthy individuals (51 females, 39 males) of both genders were included in our study. Pallidum, hippocampus, Cornu Ammonis1 (CA1), Cornu Ammonis2-3 (CA2-CA3), and Cornu Ammonis4-Dentate Gyrus (CA4-DG) measurements in females and males had a statistically higher mean in the right region (p < 0.05). In addition, females' hippocampus, CA1, CA2-CA3, and CA4-DG averages decreased more rapidly in the right region than in the left region. Subiculum measurement had a higher mean in the left region in both males and females (p < 0.05). The mean subiculum of males decreased more rapidly in the right region than in the left region. When the total values of the subcortical region in males and females were compared according to age categories, amygdala, pallidum, putamen, hippocampus, CA2-CA3, and subiculum values did not differ to gender in individuals aged 50 and over (p > 0.05). In individuals under 50 years old, the mean of females was statistically lower than the mean of males (p < 0.05). The Stratum radiatum (SR), Stratum lacunosum (SL), and Stratum molecuare (SM) asymmetry values of males in the examined subcortical regions had a higher mean than females (p = 0.039). In other regions, there was no statistically asymmetrical difference (p > 0.05). Studies evaluating the volumetric analysis and asymmetry of hippocampus subbranches and other subcortical structures in adults are very limited. As a result, the morphometry of the hippocampus subbranches and other subcortical structures was examined in detail. It was determined that the structures differed according to age, gender and body side.
PubDate: 2023-03-22
- Muscle–tendon arrangement and intramuscular nerve distribution of flexor
digitorum superficialis in the siamang (Symphalangus syndactylus), western
lowland gorilla (Gorilla gorilla gorilla), western chimpanzee (Pan
troglodytes verus), and Japanese macaque (Macaca fuscata)-
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Abstract: Abstract Flexor digitorum superficialis (FDS) shows diverse muscle–tendon arrangements among primates. The intramuscular nerve distribution pattern is a criterion for discussing the homology of FDS. In this study, the muscle–tendon arrangement and intramuscular nerve distribution of FDS were examined in the siamang, western lowland gorilla, western chimpanzee, and Japanese macaques. The FDS had muscle bellies to digits II–V. FDS had proximal belly and intermediate tendon except for siamang. Distal belly to digit II (in the western lowland gorilla and western chimpanzees) or distal bellies to digits II and V (in Japanese macaque) originated from the intermediate tendon. In all specimens, nerve branches within digit III belly extended into digit IV belly, and nerve branch(es) within digit IV belly extended into digit V belly. This consistent pattern suggested that each muscle belly to digits III–V is interspecifically homologous. The digit II belly in the siamang and the distal belly to digit II in the western lowland gorilla, western chimpanzees, and Japanese macaques could be homologous based on their similar innervating patterns. The proximal belly was innervated by branches from the communicating nerve between median and ulnar nerves in the western lowland gorilla or branches from median and ulnar nerves in western chimpanzees. In the siamang and Japanese macaque, the whole FDS was innervated by median nerve. The proximal belly in the western lowland gorilla, western chimpanzees, and Japanese macaques could be classified into different groups from the other part of the FDS.
PubDate: 2023-03-21
- Novel combination method of wide-range serial sectioning and 3D
reconstruction visualizing both macro-level dynamics and micro-level
interactions in an attempt to analyze the female pelvic floor-
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Abstract: Abstract The present report presents details of the method for combining wide-range serial sectioning and 3D reconstruction using an adult cadaver. For several decades, anatomists have utilized a variety of non-destructive three-dimensional (3D) visualization methods to complement gross anatomical analysis methods. These include vascular casting for the visualization of vascular morphology and micro-CT for the visualization of bone morphology. However, these conventional methods are restricted by the properties and sizes of the target structures. Here, we introduce a method to conduct 3D reconstruction based on wide-range serial histological sections from adult cadavers, which overcomes previous restrictions. An attempt at 3D visualization of the female pelvic floor muscles provides a detailed description of the procedure. Supplemental video and 3D PDF files allow multifaceted observation of 3D images. Wide-range serial sectioning visualizes morphology beyond the scope of conventional methods, while 3D reconstruction enables non-destructive 3D visualization of any structure that can be observed on a histological section, including skeletal muscle, smooth muscle, ligaments, cartilage, connective tissue, blood vessels, nerves, lymph nodes, and glands. The novel combination of both methods is instrumental in meso-anatomy, a discipline intermediate between macro-anatomy and micro-anatomy.
PubDate: 2023-03-07
- Penetration of the facial nerve by the posterior auricular artery: case
report, comprehensive review and clinical–surgical applications-
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Abstract: Abstract Anatomical variations between the facial nerve and adjacent arteries are rare. However, knowledge of such anatomical variations is important to the surgeon who operates on or near the facial nerve. Herein, we report an unusual finding between the extracranial part of the facial nerve and a nearby artery. During routine dissection of the right facial nerve trunk, the posterior auricular artery was found to pierce the nerve effectively forming a nerve loop. The nerve was pierced by the artery soon after its exit from the stylomastoid foramen. This case is detailed and a review on this topic presented, specifically identifying previously reported studies describing this or similar variations, and the relationship between the posterior auricular artery and facial nerve trunk in general. Piercing of the facial nerve trunk by the posterior auricular artery appears to be rare. However, such a relationship should be known by the clinician who treats patients with pathologies of the facial nerve trunk. To our knowledge, this is the first report of this variation in an adult. Due to such rarity, this case is of archival value for those who might describe it or similar cases in the future.
PubDate: 2023-03-07
- Evaluation of morphological features of palatopharyngeus insertion into
the thyroid cartilage-
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Abstract: Abstract The attachment of the palatopharyngeus extended from the posterior end of the thyroid cartilage to the posterior margin of the inferior constrictor attachment that might contribute to successive swallowing movements. Laryngeal elevation is essential for proper swallowing and breathing. Recently, clinical research has demonstrated that the palatopharyngeus, a longitudinal muscle of the pharynx, is involved in the elevation of the larynx. However, the morphological relationship between the larynx and palatopharyngeus remains unclear. In the present study, we analyzed the attachment site and characteristics of the palatopharyngeus in the thyroid cartilage. We evaluated 14 halves of seven heads from Japanese cadavers (average age: 76.4 years); 12 halves, anatomically and two halves histologically. A part of the palatopharyngeus, which originated from the inferior aspect of the palatine aponeurosis, was attached to the inner and outer surfaces of the thyroid cartilage through collagen fibers. The attachment area extends from the posterior end of the thyroid cartilage to the posterior margin of the attachment site of the inferior constrictor. The palatopharyngeus may elevate the larynx with the suprahyoid muscles and contribute to successive movements of swallowing with surrounding muscles. Based on our findings and previous studies, palatopharyngeus with various muscle bundle directions may be essential for the coordination of continuous swallowing events.
PubDate: 2023-03-06
- Substantial decrease in SARS-CoV-2 RNA after fixation of cadavers intended
for anatomical dissection-
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Abstract: Abstract With the onset of the COVID-19 pandemic, a problem arose with classic body donation programmes for obtaining cadavers for anatomical dissections, science and research. The question has emerged whether bodies of individuals who died of COVID-19 or were infected by SARS-CoV-2 could be admitted to Departments of Anatomy. To determine the risk of SARS-CoV-2 transmission to employees or students, the presence and stability of SARS-CoV-2 RNA in cadavers after fixation agents’ application and subsequent post-fixation baths over time were examined. The presence of viral RNA in swabs from selected tissues was assessed by the standardized routine RNA isolation protocol and subsequent real-time PCR analysis. To support the results obtained from the tissue swabs, samples of RNA were exposed in vitro to short and long-term exposure to the components of the injection and fixation solutions used for the bodies’ conservation. Substantial removal of SARS-CoV-2 RNA was observed in post-mortem tissue following perfusion with 3.5% phenol, 2.2% formaldehyde, 11.8% glycerol and 55% ethanol, and subsequent post-fixation in an ethanol bath. In vitro experiments showed significant effects of formaldehyde on SARS-CoV-2 RNA, while phenol and ethanol showed only negligible effects. We conclude that cadavers subjected to fixation protocols as described here should not pose a considerable risk of SARS-CoV-2 infection while being handled by students and staff and are, therefore, suitable for routine anatomical dissections and teaching.
PubDate: 2023-03-04
- Relationship between the nasal profile and craniofacial structures: does
part of the nasal profile reflect some craniofacial structures'-
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Abstract: Abstract This study aims to evaluate the relationship between the nasal profile and other craniofacial structures. Lateral cephalometric images of 124 adults were collected for this purpose. Statistical analyses such as regression analysis and canonical correlation analysis (CCA) were conducted on nasal and craniofacial anatomical parameters and their relationships. The regression analysis revealed that nasal length was related to maxillary height; nasal depth was related to the position of the maxilla and anterior cranial base length; and nasal base angle was related to upper dentoalveolar height. CCA revealed that nasal parameters (nasal length, depth, and hump) correlated more strongly with craniofacial parameters (maxillary height, anterior–posterior position of the maxilla, and maxillary length). Individuals with maxillary development curved anteriorly upwards had a straighter and smaller nasal profile, while those with maxillary development curved posteriorly downwards had a more arched and large nasal profile. The shape of the nasal dorsum was affected by the maxillomandibular rotation, while the increase in nasal base inclination was accompanied by an upward rotation of the maxillary plane, an increase in the upper dentoalveolar height, and an increase in the lower facial height. While it was observed that each nasal parameter was correlated with the underlying craniofacial structures to some extent, it was also observed that it would be more useful to evaluate the cumulative effects posed by craniofacial parameters. Various combinations of skeletal and dental structures are related to the nasal profile in varying forms and knowing these relationships will help reshape the face and provide aesthetic harmony.
PubDate: 2023-03-01
- Morphometric evaluation and classification of the superior orbital fissure
on 3D MDCT images-
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Abstract: Abstract The anatomy of the superior orbital fissure is very important because of the spaces it connects, the regions it is adjacent to, and the structures it contains. We aimed to study the width, length and types of the structure, their change according to gender, body sides, and age. The fissure shape has many variations that are not easy to systematize. Therefore, it was aimed to classify them with various reference points determined for the first time, identify their types and determine their incidence. An objective and comprehensive classification was used on 3-dimensional images using multidetector computed tomography. We retrospectively evaluated the orbit and paranasal sinus computerized tomography images of 200 individuals (age range: 3 months-90 years;106 female, 94 male). The shape of fissure were identified and classified, it is length and width were measured. There was no statistical difference in the length of the fissure according to gender on both sides, and in width only on the left (p˃0.05). On the right side, it was statistically significantly wider in female (p˂0.05). While the fissure types were grouped based on observation in the literature, they were defined more comprehensively according to different shape features by giving a certain reference lines by us for the first time and evaluated over seven types. The most common shape for both sides was racket-shaped type (right: 24.5%, left: 26%), while the least common was narrow type (right: 1%, left: 2%). Thus, the shape variations of structure have gained a systematic typing criterion for the first time with the definitions in our study.
PubDate: 2023-03-01
- Morphometric and morphological evaluation of temporozygomatic suture
anatomy in dry adult human skulls-
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Abstract: Abstract This study aims to evaluate the position, morphometric, and morphological features of the temporozygomatic suture (TZS) located on the zygomatic arch (ZA) in dry adult human skulls. Thirty-two crania were evaluated. Measurements for the TZS were carried out using the ImageJ software. Morphometric measurements were carried out bilaterally in 23 crania and unilaterally in 9 crania (right: 4, left: 5). A total of 55 TZSs were analyzed. Localization of the TZS was determined according to the reference landmarks on the ZA. Morphologic features of the TZS evaluated in terms of “joint shape type” and “suture margin pattern”. Descriptive statistics of the morphometric and morphologic variables were calculated. A statistically significant difference between the right and left sides was observed for the localization of the TZS (p < 0.05). TZS is located more anteriorly on the left side than the right side. Based on the “joint shape type”, four types of TZS were observed: Type 1 (angular) (34.55%), Type 2 (curvy) (34.55%), Type 3 (oblique) (14.55%), Type 4 (horizontal) (16.36%). Based on the “suture margin pattern”, five types of TZS were observed: Type A (linear) (12.73%), Type B (denticulate) (34.55%), Type C (serrated) (23.64%), Type D (mixt) (21.82%), Type E (fused) (7.27%). No significant association between the type and lateralization was found for both morphologic classifications. To the best of our knowledge, this is the first published report regarding the localization and morphologic classification of the TZS in adult human crania. Considering the TZS with its morphometric and morphological features may contribute to clinical or forensic medical evaluations.
PubDate: 2023-03-01
- An evaluation of mandibular canal variations: a systematic review and
meta-analysis-
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Abstract: Abstract The inferior alveolar nerve and vessels are carried via the mandibular canal, which extends bilaterally from the inferior alveolar foramen to the mental foramen. Bifid and trifid mandibular canals result from abnormal fusions of nerve canals. The purpose of this study was to provide an up-to-date and comprehensive analysis of the prevalence of mandibular canal variations among healthy adults, and to identify any potential ethnic, sex, or laterality predilections. The prevalence of the bifid mandibular canal was 18.87% and that of the trifid canal 1.3%. Unilateral variants were three times commoner than bilateral. Each mandibular half had four canals emanating from separate openings on the lingual surface of the mandibular ramus. Retromolar and forward canals were the predominant subtypes, followed by dental; buccolingual were the least frequent. The mean length and diameter of the bifid mandibular canal were 13.62 mm and 1.63 mm, respectively. The possibility of a bifid mandibular canal is a crucial consideration in dental medicine. Because anatomical variations of the mandibular canal are fairly common, awareness of them is essential for anatomy teachers and for surgeons who operate in the oromaxillofacial region.
PubDate: 2023-03-01
- Development of a new histological identification method of human
sinoatrial node suitable for immunohistochemical study-
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Abstract: Abstract Histological identification of the human sinoatrial node (SAN) remains a challenge. Conventional identification methods, such as Lev’s method, have certain limitations. The aim of our study was to develop a new histological identification method that could properly identify the sinoatrial node, applicable to the immunohistochemical study of intra-nodal structures. Thirty-nine human autopsied hearts were included in this study. The cases included 23 men and 16 women ranging in age from 20 to 99 years. The sinoatrial area from eight control samples was cut in the vertical section using the conventional Lev’s method. In our new method, called the “En face one-block method,” the sinoatrial node was cut in “En face” at the junction of the right border of the right appendage and superior vena cava, placed in one long cassette, and serially cut using a microtome. Immunostaining was performed using primary antibodies against CD31, podoplanin (D2-40), S-100, and other proteins. The average area of the SAN on the slide glass in our new method was 32.2 mm2, which was significantly larger than that (3.59 mm2) of the control samples by Lev’s method. The SAN area was positively correlated with age (r = 0.357; p = 0.026), especially in women (r = 0.626; p = 0.0095). The SAN group had significantly lower percentage of CD31-positive blood capillaries, higher percentage of podoplanin-positive lymphatic channels, and S-100-positive peripheral nerves. We successfully developed a novel cutting method applicable to immunohistochemical studies, with which we could provide a bird’s-eye view of the sinoatrial nodes.
PubDate: 2023-03-01
- The thyrocervical trunk: an analysis of its morphology and variations
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Abstract: Abstract The number of studies on the variations of the branching of the TT is scarce, and those works that treat about the different types of the said trunk are oftentimes inconsistent. Therefore, the authors of the present study would like to propose a set of five types of TT, which were created based on observations of 41 computed tomography angiographies (82 TTs). To establish the anatomical variations, their prevalence, and morphometrical data regarding the TT and its branches, a retrospective study was performed. The results of 55 consecutive patients who underwent neck and thoracic computed tomography angiography (CTA) were analyzed. The analysis was performed on a total of 82 TTs of 41 patients, aged 15 to 82 years (mean age: 46 years; SD: 18.4), of which 16 (39.0%) were females, and 25 (61.0%) were males. Initially, 11 types of variations were evaluated, of which types 1–4 constituted 89.0%. Furthermore, a new method of classification of the anatomical variations of the TTs has been established. In this study, the variety of the branching and morphology of the TT was presented, proposing its novel classification based on the five most commonly prevalent types. Types 1 and 2 were the most common, with a prevalence of 26.8% each. This work also provides physicians with crucial data about the morphology of the TT and its branches, which can surely be of use when performing endovascular or reconstructive procedures in the cervical region.
PubDate: 2023-03-01
- Anogenital distance and anal position index in cadaveric human fetuses
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Abstract: Abstract The aim of this study is to contribute to the determination of the normal values of human anogenital distance (AGD) and anal position index (API) in the antenatal period. 59 formalin-fixed human fetuses were examined. AGD was measured by the distance between the center of the anus and the posterior fourchette in females, and the distance between the center of the anus and the posterior scrotal raphe in males. API in female fetuses was determined with the formula API = fourchette–center of anus/fourchette-coccyx formula, and API = posterior scrotal raphe-center of anus/posterior scrotal raphe-coccyx in males. The mean AGDs of the female and male fetuses in the second trimester were 5.60 ± 1.60 mm and 9.64 ± 2.75 mm and 12.88 ± 4.14 mm and 17.26 ± 5.55 mm in the third trimester, respectively. The AGD values were found to be significantly higher in the males (p = 0.002). While the API values detected in the female and male fetuses were 0.43 ± 0.085 and 0.55 ± 0.072 in the second trimester, they were 0.46 ± 0.079 and 0.55 ± 0.058 in the third trimester. The API values were found to be significantly higher in the male fetuses (p < 0.001). When the distribution of API values of the fetuses in the second and third trimesters was examined, no significant difference was found (p = 0.499). In addition, no significant correlation was found between API and AGD values and percentile groups of fetuses (p ˃ 0.05). The AGD and API differed significantly between female and male fetuses starting from the antenatal second trimester, and the difference was preserved independently of the fetal percentile in the later stages of pregnancy.
PubDate: 2023-03-01
- The effects of regular swimming exercise and melatonin on the neurons
localized in the striatum of hemiparkinsonian rats-
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Abstract: Abstract Parkinson’s disease is a progressive neurodegenerative movement disorder. We aimed to investigate the effects of regular swimming exercise and melatonin applied in the 6-Hydroxydopamine-induced Parkinson’s disease rats by analysing dendritic spine of striatal neurons. Twenty-four male Wistar albino rats were used. 6-Hydroxydopamine unilaterally injected four (control, exercise, melatonin and exercise + melatonin) groups were included in the study. Tyrosine hydroxylase expression was detected by immunohistochemistry. Neurons and structures were identified from three-dimensional images by Neurolucida software. There was not any apparent difference for tyrosine hydroxylase positive neurons in the substantia nigra pars compacta and fibres in the striatum between the lesion sides of hemiparkinsonian groups. The treatment groups blocked the apomorphine-induced increase in rotations compared to the control group. In stepping test, the treatment groups prevented the loss of stepping in the contralateral side of hemiparkinsonian groups. The melatonin mostly had a positive effect on motor activity tests. In morphological analyses, the 6-Hydroxydopamine-induced lesion led to the reduction of the total dendritic length and number of branches. In the treatment groups, the reduction of the dendritic parameters was not observed. 6-Hydroxydopamine lesion led to a decrease in the total spine density, spine densities of thin and mushroom types. The exercise and melatonin treatments prevented the loss of spine density. The exercise treatment prevented the loss of spine density of mushroom type spines. The melatonin treatment blocked the loss of spine density of stubby type. In conclusion, these results provide evidence for effective additional protective therapeutic strategies for Parkinson’s disease. In conclusion, results from the current study provide evidence for swimming exercise and melatonin as a promising candidate for effective additional protective strategies for PD.
PubDate: 2023-03-01
- The red ruffed lemur, Varecia rubra (É. Geoffroy Saint-Hilaire, 1812): a
comparative morphology investigation of lingual papillae and connective
tissue cores-
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Abstract: Abstract The morphology of the lingual papillae (filiform, foliate, fungiform, and vallate papillae) and the underlying connective tissue core of the red ruffed lemur (Varecia rubra) of a strepsirrhines species were studied using light and scanning electron microscopy. The filiform papillae distributed at the root of the tongue were larger than the structures distributed at the body and apex. Six to eight vallate papillae were arranged in a Y-shape at the border between the lingual body and the lingual root. Foliate papillae were observed at the posterior lateral border of the tongue. Scanning electron microscopy revealed a primary process and numerous auxiliary processes in the epithelial layer of filiform papillae. After epithelial removal, the connective tissue core of the filiform papilla showed several protrusions surrounding an oval-shaped depression that extended slightly posteriorly, and a large, maple-shaped filiform papilla was seen in the posterior portion of the tongue. The connective tissue cores of the fungiform papillae exhibited a longitudinally ridged cylindrical structure. The connective tissue core of the foliate papillae had numerous tubular projections arranged along a groove with a salivary gland conduit at the base. As a Lemuridae species, the appearance of the fungiform and filiform papillae of the red ruffed lemur is similar to that reported in previous studies of the ring-tailed lemur, with some differences, especially in the filiform papillary connective tissue core at the base and tongue body border. These findings suggest the taxonomic and phylogenetic origins of the lemurs as well as the influence of dietary diversity.
PubDate: 2023-03-01
- A surgical modification in the technique of rat pinealectomy
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Abstract: Background Several experimental intents require pineal gland removal. The main challenge of the pinealectomy surgical procedure is the hemorrhage due to the transverse sinus torn. The study aimed to modify the rat pinealectomy surgical procedure to reduce the risk of bleeding and the mortality rate. Methods Adult male rats experienced pinealectomy surgery. A mini-drill was used to remove a small skull area in the junction of the lambda and sagittal sutures. The pineal gland was removed using a curved-head hook. Animals experienced intensive post-surgical care. Locomotion, cerebellar motor function, working memory, and anxiety were evaluated 2 weeks after pinealectomy by the open field, rotarod, Y maze, and the elevated plus maze, respectively. Results Surgical modification reduced the bleeding risk and animal mortality rate. No significant alteration was found in locomotion and working memory. However, the pinealectomy was anxiogenic and decreased entry to the open arm. The cerebellar motor performance did not change in the rotarod test. Hematoxylin–Eosin staining of removed tissue confirmed the histology of the pineal gland. Conclusion Advantages of this technique were removing a small skull area, modifying the hook insertion point to prevent damaging the brain veins, reducing the bleeding risk and the mortality rate. Surgery modification was associated with a decreased final number of animals used. Regardless of the melatonin shortage, pinealectomy affects different organs, which should be considered in the research study design.
PubDate: 2023-03-01
- Clinical and variational evaluation of peroneus tertius muscle
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Abstract: Abstract This research was conducted to define the typology of the peroneus tertius, which is considered to be a part of the musculus extensor digitorum muscle and plays a role in dorsiflexion and eversion of the foot. In addition, another aim of the study was to examine the relationship of the peroneus tertius with the extensor digitorum longus and to investigate the possible effects of the tendon/insertio properties of the peroneus tertius on the fifth metatarsal. In this study; classical anatomical dissection was performed on 30 lower limbs. In this study, various parameters related to muscle origin, insertion, tendon and muscle dimensions were measured. It has been found that PTM was absent in 26.6% of the specimens and in 23.3% (n = 7) of the cases PTM was directly originated from the EDL. In 56.7% of the specimens (n = 17), the PTM tendon was mutually inserted into the dorsomedial surface of the 5th metatarsal and dorsolateral of the 4th metatarsal, while in 10.0% of the specimens it has thin medial bands (2 × 1 mm) towards the 5th digit. At the end of the study, the PTM origin was categorized into three different types and PTM insertion was categorized into five different types. Variation of PTM, muscle morphology and tendon diameter are extremely important in terms of minimally invasive surgical technique. Since the accessory tendon must have the properties close to the tendon that will be replaced, we believe that the results of our research provide unique useful information to clinicians. This study is the cadaver research.
PubDate: 2023-03-01
- Structural changes and neurotrophic factors upregulation in submandibular
gland in a rat model of depression: proposed correlation with stress
indicators during and after the relief of depression-
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Abstract: Abstract This study evaluated the structural changes, the immunohistochemical and gene expression of neurotrophic factors in submandibular gland in a rat model of depression, and their correlation with depression parameters during and after relief of depression by voluntary running. Forty-eight male Wistar rats were divided into control, control-exercise, depression, and depression-exercise groups. Depression was induced using forced swimming protocol, while the relief of depression was induced using the rat voluntary running wheels. The depressive state of rats was evaluated by measuring the immobility duration and the serum corticosterone level. The immune expression was evaluated by measuring the optical densities (ODs) using ImageJ software, and the gene expression levels were investigated. In the depression group, the convoluted ducts appeared dilated with numerous secretory granules. The number of PCNA-stained cells was significantly decreased in the depression group as compared to control group and then significantly increased in the depression-exercise group when compared to the depression group with a negative correlation to stress indicator. The ODs of immuno-expression for the brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) increased significantly in the depression group as compared to control group. Both BDNF and VEGF immuno-expression displayed positive correlation with the stress indicators. Both BDNF and VEGF gene expression results confirmed their immunohistochemical results. The findings of this study explored the role of submandibular gland in secreting neurotrophic factors and raise a flag for the possibility of using salivary secretions as dependable and easy parameter for estimation of chronic stressed patients. Mini Abstract The submandibular gland neurotrophic factors immuno-expression can be used in estimating chronic depressive disorders as they are correlated with stress indicators during and after the relief of depression.
PubDate: 2023-03-01
- Evolutionary comparative analysis of the extrinsic thoracic limb muscles
in three procyonids (Procyon cancrivorus Cuvier, 1798, Nasua nasua
Linnaeus, 1766, and Potos flavus Schreber, 1774) based on their
attachments and innervation-
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Abstract: Abstract The procyonids (Procyon cancrivorus, Nasua nasua and Potos flavus) are Neotropical carnivorans with the ability to climb trees; however, each one has different locomotor preferences. Thereby, P. flavus is highly arboreal, P. cancrivorus is mainly terrestrial with abilities to swim, and N. nasua is also fossorial. These activities not only require movements of the hands but stabilize the thoracic limb, an action performed by the extrinsic muscles. Besides, former descriptions performed in procyonid species have obsolete terms for these muscles, generating confusion about the comparison among species. Thereby, muscle innervation has also been used to support the evolutionary derivation of the muscles. Therefore, this study aimed to describe the attachments and innervations of these muscles in three procyonids. There were intra- and interspecific anatomical variations in the attachments of all extrinsic thoracic limb muscles. However, based on the innervation, several evolutionary derivations in procyonids could be found, such as: the cleidobrachialis muscle derived from the deltoideus muscle; the atlantoscapularis muscle of P. flavus derived from the serratus ventralis cervicis muscle; the pectoralis transversus muscle derived from the pectoralis profundus and superficiales muscles; and the pectoralis abdominalis muscle derived from the cutaneus trunci muscle. Some functions could be associated with locomotor habits, among them a highly developed pectoralis abdominalis in Nasua for its fossorial habits and the atlantoscapularis in Potos for its arboreal and prehensile habits. Thus, the extrinsic muscles in procyonids have evolved for locomotor preferences, but mainly due to their phylogenetic relationship within the family Procyonidae.
PubDate: 2023-03-01
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