Authors:Krzysztof Dobrzeniecki, Natalia Hopej, Katarzyna Muc, Kacper Turek, Katarzyna Błaszczyszyn, Monika Bolek, Nicol Dardzińska, Aleksandra Grzegorczyk, Magdalena Pachla Pages: 51724 - 51724 Abstract: Introduction: Type 2 diabetes mellitus is a prevalent chronic disease with high morbidity and mortality, characterized by inadequate cellular response to insulin and insufficient insulin production by pancreatic β-cells. Epidemiological studies indicate that low serum vitamin D levels are prevalent among the general population globally, exacerbating outcomes of many diseases. Recent studies suggest that vitamin D deficiency may impact type 2 diabetes mellitus prognosis. Understanding type 2 diabetes mellitus risk factors and disease progression variables is crucial for proper patient management and public health policies. Purpose of the work: This study aims to review the relationship between vitamin D deficiency and the prognosis of type 2 diabetes mellitus. Materials and methods: A comprehensive analysis of research papers available on PubMed, Google Scholar, Web of Science, Embase and Scopus was undertaken using the search terms encompassing the following keywords: vitamin D insufficiency / vitamin D supplementation / vitamin D2 / vitamin D3 / ergocalciferol / cholecalciferol and type 2 diabetes mellitus / complications of diabetes / hyperglycemia / insulin resistance / glucose metabolism. Results: Vitamin D deficiency can impact the prognosis of type 2 diabetes mellitus, exacerbating complications associated with chronic hyperglycemia such as obesity, mental health issues, vascular complications, and diabetic neuropathy. Given its prevalence among type 2 diabetes mellitus patients, early screening and supplementation of vitamin D could offer potential benefits. PubDate: 2024-07-06 DOI: 10.12775/QS.2024.22.51724 Issue No:Vol. 22 (2024)
Authors:Krzysztof Dobrzeniecki, Natalia Olesińska, Magdalena Pachla, Aleksandra Grzegorczyk, Katarzyna Muc, Natalia Hopej, Kacper Turek Pages: 51727 - 51727 Abstract: Small intestine bacterial overgrowth (SIBO) is a gastrointestinal disorder characterized by an abnormal growth of bacterial populations within the small intestine. These conditions disrupt the balance of microorganisms in the gastrointestinal tract, leading to a variety of clinical symptoms and complications. Excessive bacterial proliferation in the small intestine often results from impaired motility, anatomical abnormalities or changes in the immune system. These factors contribute to the fermentation of undecomposed carbohydrates, leading to the production of gasses and toxic by-products, causing symptoms such as abdominal pain, bloating, diarrhea and malabsorption. A variety of diagnostic methods, including breath tests and small bowel aspirate cultures, are used to accurately identify excessive bacterial growth. Treatment of SIBO involves a multidisciplinary approach, including dietary modifications, antibiotic therapy and prokinetic agents. Antibiotic treatment remains the cornerstone of therapy, but relapses require a focus on identifying and eliminating predisposing factors. PubDate: 2024-07-06 DOI: 10.12775/QS.2024.22.51727 Issue No:Vol. 22 (2024)
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