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- Regulating effects of Neiguan (PC6) and Gongsun (SP4) on
hypothalamic-pituitary-adrenal axis in rats with functional dyspepsia-
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Abstract: Objective To investigate the effects and the possible mechanisms of Neiguan (PC6) and Gongsun (SP4) on the hypothalamic-pituitary-adrenal (HPA) axis in rats with functional dyspepsia (FD), thus to provide a theoretical basis for the clinical application of the Eight Confluent Points. Methods Forty specific-pathogen-free Sprague-Dawley rats were divided into a blank group, a model group, an electroacupuncture (EA) group, and a Western medicine group by the random number table method, with 10 rats in each group. Rats in the blank group did not receive modeling or intervention. Rats in the other three groups were subjected to the FD with mood disorder model using the compound etiology modeling method. After the successful modeling, rats in the model group did not receive any interventions, rats in the Western medicine group received deanxit and mosaprid intervention, and those in the EA group received EA intervention on the ipsilateral Neiguan (PC6) and Gongsun (SP4) for 21 d. The sugar-water consumption rate was measured before the experiment and before and after interventions to assess the emotional status. The gastric emptying rate was measured after interventions to assess the gastrointestinal dynamics. The expression levels of hypothalamic corticotropin-releasing hormone (CRH), pituitary adrenocorticotropic hormone (ACTH), and adrenal corticosterone (CORT) were measured by enzyme-linked immunosorbent assay. Results Compared with the blank group, the sugar-water consumption rate and the gastric emptying rate were decreased (P<0.01), and the hypothalamic CRH, pituitary ACTH, and adrenal CORT expression levels were increased (P<0.01) in the model group. Compared with the model group, the sugar-water consumption rate and the gastric emptying rate were significantly increased (P<0.01), while the expression levels of hypothalamic CRH, pituitary ACTH, and adrenal CORT were significantly decreased (P<0.01) in the EA group and the Western medicine group. The differences between the EA group and the Western medicine group were not statistically significant (P>0.05). Conclusion The Eight Confluent Points Neiguan (PC6) and Gongsun (SP4) can improve the mood and gastrointestinal dynamics in FD rats, which may be achieved by down-regulating the hypothalamic CRH, pituitary ACTH, and adrenal CORT, as well as by correcting the HPA axis hyperfunction.
PubDate: 2023-08-01
- Clinical observation on Yi Jin Jing (Sinew-transforming Qigong Exercises)
in improving anxiety for asymptomatic patients with COVID-19 infection
during quarantine-
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Abstract: Objective To observe the effect of Yi Jin Jing (Sinew-transforming Qigong Exercises) intervention on anxiety in asymptomatic patients with Corona Virus Disease 2019 (COVID-19) infection during quarantine. Methods A total of 160 asymptomatic patients with COVID-19 infection were stratified by gender and divided into an observation group and a control group by the stratified randomization method, with 80 cases in each group. The control group was given basic nursing in the cabin, and the observation group was given additional Yi Jin Jing exercises once a day, 20 min each time, and trained continuously until 1 d before leaving the cabin. The Hamilton anxiety scale (HAMA) score was compared between the two groups. Results A total of 154 cases were included for data analysis in this study, including 74 cases in the observation group and 80 cases in the control group. After intervention, the HAMA scores in both groups increased (P<0.05), while the score in the observation group was lower than that in the control group (P<0.05). In the control group, the HAMA score of females after intervention was higher than that of males. The scores of mental anxiety and somatic anxiety in both groups were higher than those before intervention, while the score of mental anxiety in the observation group was significantly lower than that in the control (P<0.05). However, there was no statistical difference in the somatic score between the two groups (P>0.05). Conclusion Patients with COVID-19 infection will get anxious during quarantine. Yi Jin Jing exercise can effectively reduce the aggravation of anxiety in asymptomatic patients with COVID-19 infection during concentrated quarantine.
PubDate: 2023-08-01
- Effects of long-time needle retaining at Baihui (GV20) on post-stroke
cognitive impairment-
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Abstract: Objective To observe the clinical efficacy of long-time needle retaining at Baihui (GV20) on post-stroke cognitive impairment (PSCI) and its effects on the cognitive ability and living ability of the patients. Methods A total of 62 PSCI patients were divided into a control group and an observation group by the random number table method, with 31 cases in each group. The control group was treated with routine treatment for stroke in the recovery period plus cognitive training. The observation group received additional acupuncture at Baihui (GV20) with long-time needle retaining based on the same intervention in the control group. The Montreal cognitive assessment (MoCA) was used to evaluate the cognitive ability of patients. The activities of daily living (ADL) scale was used to evaluate the living ability of patients. And the mini-mental state examination (MMSE) scale was used to evaluate the mental state, concentration, language, and abstraction cognition of patients. After 4 weeks, the curative efficacy was observed, and the scores of cognitive level, living ability, mental state and concentration, language, and abstraction understanding ability were compared between the two groups. Results During the trial, 1 patient in each group dropped out due to personal reasons and was unable to continue the treatment. After 4 weeks of treatment, the total effective rate was 83.3% in the observation group and 66.7% in the control group, and the difference between the two groups was statistically significant (P<0.05); the scores of MoCA, ADL, and MMSE, and scores of concentration, language ability, and abstraction understanding ability were all increased, and were statistically different from those before treatment in each group (P<0.05); the scores in the observation group were all higher than those in the control group, and the differences between the groups were statistically significant (P<0.05). Conclusion On the basis of routine treatment and cognitive training, the clinical efficacy of additional acupuncture at Baihui (GV20) with long-time needle retaining in the treatment of PSCI is better than that of routine treatment plus cognitive training; the treatment can better improve the cognitive function and mental state of patients, and improve their living ability.
PubDate: 2023-08-01
- Effects of acupuncture at Houxi (SI3) and Huantiao (GB30) on
NF-κB/iNOS/NO pathway in lumbar disc herniation model rats-
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Abstract: Objective To observe the effects of acupuncture at Houxi (SI3) and Huantiao (GB30) on the expression levels of nuclear factor kappa B (NF-κB), inducible nitric oxide synthase (iNOS), and nitric oxide (NO) of NF-κB inflammatory signaling pathway in L5 spinal nerve root of lumbar disc herniation (LDH) model rats and explore the mechanism of acupuncture in LDH treatment. Methods Forty specific-pathogen-free healthy male Sprague-Dawley rats were randomly divided into a sham operation group, a model group, acupuncture group 1, and acupuncture group 2, with 10 rats in each group. The non-compression nucleus protrusion model was made by puncturing L4–L5 spinous process space and injecting autologous nucleus suspension. Acupuncture at bilateral Shenshu (BL23), Dachangshu (BL25), and Weizhong (BL40) was carried out in acupuncture group 1, and acupuncture at bilateral Houxi (SI3) and Huantiao (GB30) in acupuncture group 2. All rats were treated with balanced reinforcing and reducing needling manipulations, and the needles were retained for 30 min/time with one episode of needling manipulation every 10 min, once a day, 14 times in total. The threshold value of paw withdrawal pain was measured by a thermal stimulation pain instrument; the serum NF-κB, iNOS, and NO levels were measured by enzyme-linked immunosorbent assay. The pathomorphological changes of spinal nerve roots were observed by hematoxylin-eosin (HE) staining; quantitative reverse transcription polymerase chain reaction was used to detect iNOS mRNA expression in spinal nerve roots; the NF-κB and iNOS protein expression in spinal nerve roots was detected by the immunofluorescence method. Results Compared with the sham operation group, the threshold of paw withdrawal pain in the model group was decreased, and the expression levels of serum NF-κB, iNOS, and NO were increased; HE staining showed many degenerated and dissolved Schwann cells in spinal nerve roots with vacuolar changes; meanwhile, the expression levels of NF-κB and iNOS proteins, and the iNOS mRNA in spinal nerve roots were increased. Compared with the model group, the paw withdrawal pain thresholds in acupuncture group 1 and acupuncture group 2 were increased, and the increase in acupuncture group 2 was greater (P<0.05); the expression levels of serum NF-κB, iNOS, and NO in acupuncture group 1 and acupuncture group 2 were decreased, especially in acupuncture group 2 (P<0.01); the vacuolar changes of spinal nerve roots, and the degeneration and lysis of Schwann cells in acupuncture group 1 and acupuncture group 2 were decreased, which were more obvious in acupuncture group 2; the NF-κB and iNOS protein expression and the iNOS mRNA expression levels in spinal nerve roots of acupuncture group 1 and acupuncture group 2 were decreased, especially in acupuncture group 2 (P<0.01). Conclusion Acupuncture at Houxi (SI3) and Huantiao (GB30) can improve the morphology of spinal nerve roots, inhibit the NF-κB and iNOS protein expression levels in spinal nerve roots and the serum NO level, and relieve the pain caused by inflammation of spinal nerve roots, which may be one of the mechanisms of acupuncture in LDH treatment.
PubDate: 2023-08-01
- Efficacy observation of pushing Qiaogong point with different intensities
for treating stage I essential hypertension-
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Abstract: Objective To observe the clinical efficacy of pushing Qiaogong point with varying intensities for treating stage I essential hypertension. Methods A total of 72 patients diagnosed with stage I essential hypertension were enrolled in this study. They were divided into three groups using the random number table method, including a control group, a gentle pushing group, and a heavy pushing group, with 24 patients in each group. All three groups received the same therapeutic lifestyle interventions. The control group received no additional interventions, the gentle pushing group received additional pushing Qiaogong point with gentle strength, and the heavy pushing group received additional pushing Qiaogong point with heavy strength. The treatment duration was 4 weeks, followed by a 4-week follow-up period, during which blood pressure changes were observed and analyzed in all three groups. Results After treatment, the blood pressure levels in all three groups showed a significant decrease (P<0.05). The effective rate in the control group was 43.5%, in the gentle pushing group was 78.3%, and in the heavy pushing group was 33.3%. The reduction in blood pressure levels in the gentle pushing group was significantly superior to that in both the control group and the heavy pushing group, indicating inter-group statistical significance (P<0.01). The efficacy of the heavy pushing group was comparable to that of the control group, indicating no statistical significance (P>0.05). During the follow-up period, compared with the end of the treatment within the same group, the blood pressure levels remained stable in both the control group and the gentle pushing group, indicating no intra-group statistical significance (P>0.05). The heavy pushing group showed a significant decrease in diastolic blood pressure (DBP) and mean blood pressure (MBP) compared with the end of the treatment, indicating intra-group statistical significance (P<0.05). During the follow-up, the gentle pushing group had lower systolic blood pressure (SBP) and MBP compared with both the heavy pushing group and the control group, indicating inter-group statistical significance (P<0.01), while there was no inter-group statistical significance in comparing the DBP (P>0.05). There was no statistical significance in comparing the SBP, DBP, and MBP between the heavy pushing group and the control group (P>0.05). Conclusion Pushing Qiaogong point with gentle strength combined with lifestyle interventions showed a higher effective rate and long-term blood pressure stability in the treatment of stage I essential hypertension. Pushing Qiaogong point with varying intensities showed varying effects on patients with stage I essential hypertension.
PubDate: 2023-08-01
- Clinical study of acupuncture combined with medication in the treatment of
skin pruritus in maintenance hemodialysis patients-
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Abstract: Objective To observe the clinical effect of acupuncture combined with Western medicine in the treatment of skin pruritus in maintenance hemodialysis patients. Methods Eighty patients were randomly divided into a control group and an observation group, with 40 cases in each group. The control group was given loratadine orally, and the observation group was given acupuncture treatment in addition to the treatment used in the control group. The four-item itch questionnaire (FIIQ) score, indicators for skin barrier function, and serum interleukin (IL)-2 and IL-31 levels were compared. The efficacy was judged after the treatment ended. Results The total effective rate was higher in the observation group than in the control group (P<0.05). After treatment, the site, frequency, severity of pruritus, sleep impact sub-scores, and FIIQ total score in both groups were reduced compared with those before treatment (P<0.05), and all scores in the observation group were lower than those in the control group (P<0.05). The stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in the V-shaped area of the chest, the flexor side of the forearm, and the extensor side of the lower leg were not significantly changed in the control group (P>0.05); the SCH and TEWL in the V-shaped area of the chest, the flexor side of the forearm, and the extensor side of the lower leg in the observation group were improved (P<0.05), and all were better than those in the control group (P<0.05). The serum IL-2 and IL-31 levels in the control group did not change significantly (P>0.05); the serum IL-2 and IL-31 levels in the observation group were both significantly decreased (P<0.05) and were lower than those in the control group (P<0.05). Conclusion Acupuncture combined with loratadine is highly effective in the treatment of pruritus in maintenance hemodialysis patients, and it can relieve pruritus, improve skin barrier function, and reduce serum IL-2 and IL-31 levels.
PubDate: 2023-08-01
- Effects of combined acupuncture and medication on hyperarousal state and
serum copeptin in patients with chronic insomnia-
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Abstract: Objective To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin (CPT) in patients with chronic insomnia (CI), and to explore its possible mechanism of action. Methods A total of 70 CI patients meeting the inclusion criteria were divided into an observation group and a control group by the random number table method, with 35 cases in each group. The control group was given estazolam tablets before bedtime, 1 mg/time, once a day. The observation group was treated with additional Yi Nao An Shen acupuncture therapy (acupuncture for benefiting the brain and tranquillization) on the basis of the medication treatment, 4 times a week. After 4 weeks of treatment, the Pittsburgh sleep quality index (PSQI) score, insomnia severity index (ISI) score, pre-sleep arousal scale (PSAS) score, hyperarousal scale (HAS) score, and the change in serum CPT level were compared between the two groups. Results During the study, there were 2 dropout cases in the observation group and 1 dropout case in the control group. After treatment, the PSQI, ISI, PSAS, and HAS scores and the serum CPT level in both groups decreased compared with the same group before treatment, and the intra-group differences were statistically significant (P<0.05). After treatment, changes in each above scale score and the serum CPT level in the observation group were much more significant and were statistically different from those in the control group (P<0.05). Conclusion Acupuncture plus medication can improve sleep quality, reduce the degree of insomnia, and regulate hyperarousal state in patients with CI, and its mechanism of action may be related to the down-regulation of serum CPT level.
PubDate: 2023-08-01
- Effects of sparrow-pecking moxibustion on the temperature and blood flow
perfusion of moxibustion point area and uterus and serum AVP, PGF2α, and
TXB2 in rats with dysmenorrhea-
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Abstract: Objective To observe the effects of sparrow-pecking moxibustion at Shenque (CV8) and Guanyuan (CV4) on the writhing reaction and score, the temperature and blood flow perfusion of moxibustion point area and uterus, the serum levels of arginine vasopressin (AVP), prostaglandin (PG) F2α, and thromboxane (TX) B2 in rats with primary dysmenorrhea (PD) due to cold-dampness stagnation, and to explore the possible mechanism of sparrow-pecking moxibustion in treating PD. Methods Thirty-two healthy non-pregnant female Wistar rats were randomly divided into a normal group, a model group, an ibuprofen group, and a sparrow-pecking moxibustion group, with 8 rats in each group. Except for the normal group, the other three groups were subjected to modeling with cold water bath combined with estradiol benzoate and oxytocin injection. Rats in the sparrow-pecking moxibustion group were treated with sparrow-pecking moxibustion at Shenque (CV8) and Guanyuan (CV4) on the 8th day of modeling, 30 min/time, once a day for 3 d; those in the ibuprofen group were treated with 0.8 mL ibuprofen solution (a specification of 125 mg in 10 mL) on the 8th day of modeling, once a day for 3 d; those in the normal group and the model group were given 0.8 mL normal saline, once a day for 3 d. On the 11th day, rats in each group were intraperitoneally injected with oxytocin (2 U/rat), and the writhing incubation period and writhing score in 20 min were observed; the temperature and the blood perfusion of Shenque (CV8), Guanyuan (CV4), and uterus in vivo were detected; the serum levels of AVP, PGF2α, and TXB2 were determined. Results The writhing incubation period was significantly longer (P<0.01) and the writhing score was significantly lower (P<0.01) in the sparrow-pecking moxibustion group and the ibuprofen group than in the model group; compared with the ibuprofen group, the writhing incubation period was prolonged (P<0.01) and the writhing score was decreased (P<0.01) in the sparrow-pecking moxibustion group; compared with the normal group, the temperature and the blood perfusion of Shenque (CV8), Guanyuan (CV4), and uterus were significantly decreased, while the serum PGF2α, AVP, and TXB2 levels were significantly increased (P<0.01) in the model group; compared with the model group, the temperature and the blood perfusion of Shenque (CV8), Guanyuan (CV4), and uterus were significantly increased, and the serum levels of PGF2α, AVP, and TXB2 were significantly decreased in the ibuprofen group and the sparrow-pecking moxibustion group (P<0.05 or P<0.01); compared with the ibuprofen group, the temperature and the blood perfusion of Shenque (CV8), Guanyuan (CV4), and uterus were significantly increased (P<0.05), the serum AVP and TXB2 levels were significantly decreased (P<0.05), while the serum PGF2α level had no statistical difference in the sparrow-pecking moxibustion group (P>0.05). Conclusion Sparrow-pecking moxibustion had a remarkable analgesic effect on the rats with PD due to cold-dampness stagnation, and the mechanism may be related to the increased temperature and blood perfusion of the moxibustion point area and uterus, as well as the decreased serum PGF2α, AVP, and TXB2 levels.
PubDate: 2023-08-01
- Randomized controlled trials of acupuncture for the treatment of essential
hypertension: a meta-analysis-
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Abstract: Objective To systematically assess the efficacy and safety of acupuncture therapy for essential hypertension. Methods A computerized literature search of the Chinese National Knowledge Infrastructure (CNKI), Chongqing VIP Database (CQVIP), Wanfang Academic Journal Full-text Database (Wanfang), China Biology Medicine Disc (CBM), PubMed, EMBASE, and Cochrane Library was conducted to retrieve randomized controlled clinical trials on acupuncture as the main intervention for the treatment of essential hypertension published from the inception of the database to 30 January 2021. The risk-of-bias assessment was carried out for each included study according to the Cochrane Handbook. Data analysis was performed using Review Manager 5.4.1 and Stata 15.0. Results After the screening, 46 randomized controlled trials involving a total of 3 859 subjects were included. Primary outcomes included changes in the diastolic blood pressure after intervention [eight studies showed that the acupuncture plus antihypertensive drug group was better than the antihypertensive drug monotherapy group [mean difference (MD)=1.45, 95% confidence interval (CI) (0.48, 2.43), P=0.004, fixed effects model; I2=39%] and changes in the systolic blood pressure after intervention {11 studies showed that the acupuncture plus antihypertensive drug group was better than the antihypertensive drug monotherapy group [MD=8.60, 95%CI (7.12, 10.07), P<0.00001, fixed effects model; I2=26%]}. The secondary outcome was antihypertensive efficacy, 12 studies of acupuncture monotherapy group [risk ratio (RR)=1.20, 95%CI (1.12, 1.28), P<0.00001, fixed effects model; I2=36%] and 15 studies of acupuncture combined with antihypertensive drug group [RR=1.27, 95%CI (1.20, 1.34), P<0.00001, fixed effects model; I2=6%] showed better results than the antihypertensive drug monotherapy group in antihypertensive efficacy. In terms of the adverse events, four studies showed that the acupuncture monotherapy group had fewer adverse events than the antihypertensive drug monotherapy group [RR=0.10, 95%CI (0.04, 0.25), P<0.00001, fixed effects model; I2=0%]. Conclusion Acupuncture combined with antihypertensive drugs is superior to antihypertensive drugs alone in reducing blood pressure, and acupuncture therapy is effective and safe for the treatment of essential hypertension with fewer side effects. However, there is still a lack of high-quality multicenter randomized double-blinded controlled trials in this field. Rigorous large-sample clinical trials are needed to validate these findings.
PubDate: 2023-08-01
- Clinical observation of acupuncture with host-guest combination using
Yuan-Primordial and Luo-Connecting points plus Tuina for the third lumbar
transverse process syndrome-
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Abstract: Objective To observe the effects of acupuncture at Yuan-Primordial and Luo-Connecting points by host-guest combination plus Tuina (Chinese therapeutic massage) on the third lumbar transverse process syndrome. Methods A total of 88 patients with the third lumbar transverse process syndrome were selected and divided into an observation group and a control group according to the random number table method, with 44 cases in each group. The control group was treated with Tuina, and the observation group was treated with additional acupuncture at Yuan-Primordial and Luo-Connecting points by host-guest combination. The clinical efficacy of the two groups was compared after treatment. The changes in the scores of physical signs, Roland-Morris disability questionnaire (RMDQ), Oswestry disability index (ODI), Quebec back pain disability scale (QBPDS), and pain factors [including serum prostaglandin (PG) E2, neuropeptide Y (NPY), and matrix metalloproteinase-3 (MMP-3)] were observed. Results After treatment, the total effective rate in the observation group was 93.2%, higher than 75.0% in the control group; the difference between the two groups was statistically significant (P<0.05). Compared with those before treatment, the scores of physical signs and each low back pain scale, and the levels of serum pain factors in the two groups were decreased (P<0.05), and those in the observation group were lower than those in the control group (P<0.05). Conclusion Acupuncture at Yuan-Primordial and Luo-Connecting points by host-guest combination plus Tuina is effective in the treatment of the third lumbar transverse process syndrome; it can improve the patient’s physical signs, relieve low back pain, and reduce the levels of serum pain factors.
PubDate: 2023-08-01
- Preparation of static training animal models and research status analysis
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Abstract: Abstract As a form of Tuina (Chinese therapeutic massage) Qigong exercises and an essential part of exercise therapy, static training has proven clinical efficacy. However, further evidence is required to reveal its mechanism of action provided by animal experiments. There are four major ways to establish static training animal models: pole climbing, hind-limb suspension, isometric-contraction weight bearing, and electrical stimulation. These models have been used to study diseases of the motor, circulatory, and endocrine systems, etc., and the mechanism has got extensive exploration. It reviewed static training animal models and the research progress to provide theoretical evidence for static training’s experimental research and mechanism exploration.
PubDate: 2023-08-01
- Clinical study of treating somatoform pain disorder with the combination
of electroacupuncture and duloxetine-
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Abstract: Objective To observe the clinical efficacy of treating somatoform pain disorder (SPD) with electroacupuncture (EA) at the Governor and Conception Vessel points plus duloxetine. Methods Eighty-two SPD patients were randomly allocated to an observation group and a control group, with 41 cases in each group. The control group was intervened by oral administration of duloxetine hydrochloride enteric capsules at a dose of 60 mg per time once a day; based on the medication, the observation group received additional EA treatment by selecting points from the Governor and Conception Vessels. Clinical efficacy was evaluated after 8 weeks of treatments; changes in the scores of the short-form McGill pain questionnaire (SF-MPQ), self-report symptom inventory, symptom check list-90 (SCL-90), Pittsburgh sleep quality index (PSQI), and generic quality of life inventory-74 (GQOLI-74) were also compared. Results After the intervention, the observation group surpassed the control group in comparing the total effective rate (P<0.05). The SF-MPQ score, SCL-90 somatization score, and PSQI score dropped notably in both groups after treatment, and the intra-group differences were statistically significant (P<0.05); the three scores were significantly lower in the observation group than in the control group (P<0.05). The GQOLI-74 score got an increase in each dimension in both groups after treatment, and the intra-group differences were also statistically significant (P<0.05); the GQOLI-74 dimension scores were all significantly higher in the observation group than in the control group (P<0.05). Conclusion For patients with SPD, combining EA at the Governor and Conception Vessel points and duloxetine hydrochloride enteric capsules can markedly improve their clinical symptoms and quality of life.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1378-0
- Electroacupuncture stimulation attenuates corpus striatum white matter
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Abstract: Objective To investigate the effect and the mechanism of electroacupuncture (EA) on corpus striatum white matter injury in rats with focal cerebral ischemia (FCI). Methods Forty-four specific-pathogen-free Sprague-Dawley rats were divided into a normal group (n=10), a sham-operation group (sham group, n=10), and a modeling group (n=24) using the random number table method. The normal group was a blank control. In the sham group, only the vessels and vagus nerve were isolated without embolization. The FCI rat model in the modeling group was replicated using the middle cerebral artery occlusion embolization method. The 20 successfully modeled rats were randomly divided into a model group and an EA group, with 10 rats in each group. Rats in the model group did not receive further treatment. Rats in the EA group received EA stimulation at Baihui (GV20) and the left Zusanli (ST36) 24 h after the successful modeling, 30 min each time, once a day for 14 d. On the 14th day of the experiment, rats in each group were scored for neurological deficits and then sacrificed, and brain tissues containing corpus striatum around the ischemic focus were paraffin-embedded from 5 rats in each group. Luxol fast blue (LFB) staining was used to detect damage changes in the white matter. The positive immunoreactive expression of myelin basic protein (MBP), myelin-associated growth inhibitor A (Nogo-A) and its receptor (NgR) in rat corpus striatum tissue was detected by immunohistochemistry staining, and then the protein expression of MBP, Nogo-A, and NgR in the corpus striatum tissue around the ischemic focus was determined by Western blotting. Results Compared with the normal group and the sham group, the model group had a significantly higher neurological deficit score (P<0.05) and fiber bundle injuries in the corpus striatum white matter, evidenced by a significantly lower mean optical density value of corpus striatum LFB staining (P<0.05), a significantly lower MBP expression level (P<0.05), and significantly higher Nogo-A and NgR protein expression levels (P<0.05). Compared with the model group, the neurological deficit score was significantly lower (P<0.05), the mean optical density value of LFB staining was significantly higher (P<0.05), the MBP expression level was increased (P<0.05), and the expression levels of Nogo-A and NgR proteins were decreased (P<0.05) in the EA group. Conclusion EA reduces the ischemia-induced corpus striatum white matter injury and improves neurological deficits. The mechanism may be related to the inhibition of Nogo-A/NgR activation.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1373-5
- Efficacy and safety of acupuncture-moxibustion for cerebral palsy-induced
speech impairment: a systematic review and meta-analysis-
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Abstract: Objective To evaluate the efficacy and safety of acupuncture-moxibustion in the treatment of cerebral palsy-related speech impairment. Methods A systematic literature search of 7 electronic databases was conducted between January 7, 2000 and January 12, 2021 to find randomized controlled trials (RCTs) examining the benefits of acupuncture-moxibustion combined with rehabilitation training to cerebral palsy-induced speech impairment. The included trials’ quality was assessed using the Cochrane Reviewers’ Handbook as a guide, and statistical analysis was carried out using the RevMan 5.3 software. Results A total of 17 RCTs with 1 238 subjects were finally recruited and analyzed. When acupuncture- moxibustion was combined with rehabilitation training, the results showed a considerable improvement in speech impairment compared with the rehabilitation training alone. The most commonly used points for the treatment of speech disorders are Baihui (GV20), Speech Area, Zhisanzhen [Shenting (GV24) and bilateral Benshen (GB13)], Niesanzhen [2 Cun above the ear tip as the first point, with 1.0 Cun anterior and posterior to the current point as the second and third points], and Sishenzhen [1.5 Cun anterior, posterior, and bilateral to Baihui (GV20)]. Conclusion Acupuncture-moxibustion has a stronger effect on children’s development of receptive and expressive language, as well as the developmental quotient. Acupuncture-moxibustion in combination with rehabilitation training is not only more successful than the control treatment, but also safer and more dependable. Baihui (GV20), Speech Area, Zhisanzhen, Niesanzhen, and Sishenzhen are the most widely used points for speech impediment.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1380-6
- Effects of horse-riding squat exercise plus Governor Vessel-regulating
Tuina therapy on static balance function in patients with stroke-
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Abstract: Objective To observe the effect of horse-riding squat exercise plus Governor Vessel-regulating Tuina (Chinese therapeutic massage) therapy on static balance function in patients with stroke. Methods A total of 176 stroke patients were enrolled as the study subjects and divided into four groups by the random number table method, namely horse-riding squat + Tuina group, horse-riding squat group, Tuina group, and control group, with 44 cases in each group. The control group was treated with rehabilitation balance training. The horse-riding squat + Tuina group, horse-riding squat group, and Tuina group were treated with additional horse-riding squat exercise plus Tuina, horse-riding squat exercise, and Tuina treatment, respectively. Four weeks of treatment was regarded as one treatment course. After 1 treatment course, the balance function of the four groups was compared. Results After treatment, the ellipse area of motion and the length of motion in all four groups were reduced, and the intra-group differences were all statistically significant (P<0.05). The difference in the ellipse area of motion before and after treatment in the horse-riding squat + Tuina group and the horse-riding squat group was larger than that in the control group, and the differences were statistically significant (P<0.05). The difference in the ellipse area of motion before and after treatment in the horse-riding squat + Tuina group was larger than that in the Tuina group, and the difference was statistically significant (P<0.05). The difference in the length of motion before and after treatment in the horse-riding squat + Tuina group, the horse-riding squat group, and the Tuina group was greater than that in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the pairwise comparison between the horse-riding squat + Tuina group, the horse-riding squat group, and the Tuina group (P>0.05). Conclusion Horse-riding squat exercise plus Governor Vessel-regulating Tuina therapy can effectively improve the static balance function in patients with stroke. Training the affected lower limb weight-bearing exercise, adjusting the center of gravity distribution, and promoting the mutual balance and coordination between muscle groups may be the mechanism of improving the static balance function.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1376-2
- Study on the antipyretic mechanism of large pushing Tianheshui for young
rabbits with endotoxin-induced fever-
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Abstract: Objective To observe the effect of large pushing Tianheshui manipulation intervention on the body temperature of young rabbits with endotoxin-induced fever and discuss its antipyretic mechanism. Methods Thirty-two young rabbits meeting the standards were selected from 40 ordinary young male New Zealand rabbits after being adapted for 7 d, and randomly divided into a normal group, a model group, a large pushing Tianheshui group, and an ibuprofen group according to the random number table method, with 8 rabbits in each group. Rabbits in the model group, the large pushing Tianheshui group, and the ibuprofen group were subjected to preparing the endotoxin-induced fever model by intravenous lipopolysaccharide from the marginal ear vein. Rabbits in the large pushing Tianheshui group received Tuina (Chinese therapeutic massage) manipulation intervention 1.5 h and 2.5 h after modeling, respectively. Rabbits in the ibuprofen group were intragastrically given ibuprofen suspension 1.5 h after modeling. The dynamic changes in body temperature were observed for the young rabbits after fever modeling. Enzyme-linked immunosorbent assay was used to determine the content changes in positive mediators of hypothalamic body temperature, including prostaglandin (PG) E2 and cyclic adenosine monophosphate (cAMP), as well as negative mediators of hypothalamic body temperature, including arginine vasopressin (AVP) and α-melanocyte stimulating hormone (α-MSH). Results The body temperature of the young rabbits in the model group was significantly higher than that in the normal group at 0.5–4.0 h, 5.0 h, and 5.5 h after modeling (P<0.01), showing two obvious fever peaks in the model group at 1.5 h and 3.0 h after modeling, respectively, with the highest peak at 1.5 h. Compared with the model group, body temperatures of the large pushing Tianheshui group and the ibuprofen group decreased significantly after 0.5 h of intervention (P<0.05). Compared with the normal group, the contents of PGE2 and cAMP were significantly increased (P<0.05), and the contents of AVP and α-MSH were significantly decreased (P<0.01) in the hypothalamus of the model group. Compared with the model group, the contents of PGE2 and cAMP were significantly decreased (P<0.01), and the levels of AVP and a-MSH were significantly increased (P<0.01) in the hypothalamus in the large pushing Tianheshui group and the ibuprofen group. There were no significant differences in the PGE2, cAMP, AVP, and α-MSH contents in the hypothalamus between the ibuprofen group and the large pushing Tianheshui group (P>0.05). Conclusion Large pushing Tianheshui manipulation has a significant antipyretic effect on endotoxin-induced fever in young rabbits. The mechanism may be related to inhibiting the positive regulators (PGE2 and cAMP) and promoting the negative regulators (AVP and α-MSH) of hypothalamic control of body temperature.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1374-4
- Clinical observation of Tuina combined with Bu Zhong Yi Qi Tang in the
treatment of rectocele-
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Abstract: Objective To observe the clinical effect of Tuina (Chinese therapeutic massage) combined with Bu Zhong Yi Qi Tang (Middle Jiao-supplementing and Qi-boosting Decoction) in the treatment of rectocele of Qi sinking due to spleen deficiency. Methods A total of 108 patients with rectocele (grades I and II) were randomly divided into a Chinese medicine group and a Tuina + Chinese medicine group, with 54 cases in each group. Both groups were treated with Bu Zhong Yi Qi Tang, and the Tuina + Chinese medicine group was treated with additional Tuina manipulation. The score of clinical symptoms and grade of rectocele were observed and compared between the two groups. Results After treatment, 39 cases were cured, 10 cases were effective, and 5 cases failed in the Tuina + Chinese medicine group, making a total effective rate of 90.7%. In the Chinese medicine group, 26 cases were cured, 16 cases were effective, and 12 cases failed, making a total effective rate of 77.8%. The efficacy difference between the two groups was statistically significant, checked by the rank-sum test (P<0.05). After treatment, the grades of rectocele in the two groups were statistically different from those before treatment (P<0.05), and the difference between the two groups was statistically significant (P<0.05). After treatment, the score of each item and the total score of traditional Chinese medicine symptoms in the two groups were lower than those before treatment, and the differences within the group were statistically significant (P<0.05). The score of each item and the total score of the Tuina + Chinese medicine group were lower than those of the Chinese medicine group, and the differences between the two groups were statistically significant (P<0.05). Conclusion Tuina plus Bu Zhong Yi Qi Tang has better clinical efficacy than Bu Zhong Yi Qi Tang alone in the treatment of rectocele of Qi sinking due to spleen deficiency.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1379-z
- Acupuncture intervening depressive disorder: research progress in its
neurobiological mechanism-
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Abstract: Abstract Depressive disorder seriously affects people’s physical and mental health. Acupuncture is a safe and effective treatment for depression, yet, its mechanism is unclear. Therefore, acupuncture’s action mechanism in intervening depression was summarized from several perspectives, including morphology and ultrastructure of neurons in depression-related brain areas, function and structure of glial cells, brain functional and structural connectivity, and neuroelectrophysiology. It’s discovered that acupuncture can repair the morphological and ultrastructural damage of neurons in the hippocampus and prefrontal lobe, mitigate the functional and structural injuries of glial cells in the hippocampus and prefrontal lobe, strengthen functional connectivity and heal structural connection, and promote neuroelectrophysiological activities, which possibly are the principal mechanisms of how acupuncture works in intervening depressive disorder.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1381-5
- Observation on the efficacy of traditional Qigong exercise combined with
Tuina manipulations in treating lower cervical disc herniation-
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Abstract: Objective To observe the efficacy of traditional Qigong exercise combined with Tuina (Chinese therapeutic massage) manipulations in treating lower cervical disc herniation (CDH). Methods A total of 120 CDH patients who met the inclusion criteria were randomly divided into an observation group and a control group, with 60 cases in each group. Patients in both groups were given the same Tuina manipulations. In addition, patients in the observation group practiced traditional Qigong exercise, and those in the control group did conventional neck exercise. After 8 weeks of treatment, the efficacy of the two groups was observed. Follow-up was conducted 3 months after the end of the treatment to record any recurrence. Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The improvement in symptom scores was more significant in the observation group than in the control group (P<0.05). There was inter-group statistical significance in comparing the cross-sectional area and fatty infiltration of certain cervical muscles (P<0.05). In addition, the recurrence rate in the observation group was lower than that in the control group (P<0.05). Conclusion On the basis of the same Tuina manipulation treatment, the efficacy of traditional Qigong exercise in treating CDH is superior to that of conventional neck exercise, with more significant improvements in pain and quality of life and a lower recurrence rate.
PubDate: 2023-06-01
DOI: 10.1007/s11726-023-1377-1
- Clinical observation of acupuncture treatment for children with
accommodative myopia-
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Abstract: Objective To observe the effect of acupuncture in the treatment of accommodative myopia in children. Methods A total of 76 children with accommodative myopia who met the inclusion criteria were divided into a control group or a test group according to the random number table method, with 38 cases in each group. The control group was given education on eye hygiene, and the test group was treated with acupuncture twice a week for 2 months in addition to the intervention used in the control group. The patient’s uncorrected visual acuity (UCVA), refraction, and axial length (AL) were measured before treatment and 1 month and 2 months after treatment. Results After 1 month of treatment, there was no significant difference in the UCVA between the two groups (P>0.05); after 2 months of treatment, the UCVA of the test group was better than that of the control group (P<0.05). After 1 and 2 months of treatment, the refraction of the two groups was significantly different from that before treatment (P<0.01), but there was no significant difference between the two groups (P>0.05). After 1 and 2 months of treatment, the AL in the control group was increased compared with that before treatment (P<0.05), while there was no significant change in the test group (P>0.05), and there was no significant difference between the two groups (P>0.05). Conclusion Acupuncture treatment can improve UCVA in children with accommodative myopia.
PubDate: 2023-02-18
DOI: 10.1007/s11726-023-1363-7
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