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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
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European Journal of Medicinal Plants
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2231-0894
Published by SCIENCEDOMAIN international Homepage  [66 journals]
  • Assessment of Ameliorative Role of Citrullus vulgaris (Schrad) Seeds on
           Caffeine-induced Hepatic and Renal Dysfunction in Male Wistar Rats

    • Authors: Akinwunmi Kemi Feyisayo , Suleiman Aishat Toyin , Obisakin Ayomiposi Blessing , Famurewa Akindele Joshua
      Pages: 1 - 14
      Abstract: Caffeine is the most widely consumed psychoactive drug in the world. It is often marketed for its physical and cognitive performance benefits. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. The ingestion of potentially toxic amounts of caffeine in the forms of energy drinks, over-the-counter supplements, addiction or use of anhydrous caffeine products places individuals at risk for accidental overdose. An overdose of this drug is not without its attendant consequences on the liver and the Kidney. This study therefore aimed at evaluating the possible hepatoprotective and nephroprotective effects of Citrullus vulgaris seed extracts on caffeine induced toxicity. Thirty (30) male Wistar rats were divided into five groups. They were induced with caffeine (100 mg/kg) and treated with graded doses (100, 300 and 500 mg/ kg bwt.) of aqueous seeds extract of C. vulgaris for 21 days. The plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were determined and the concentrations of total protein, albumin, total bilirubin, creatinine and urea were estimated. Electrolytes (sodium, calcium, potassium and magnesium ion) were also estimated. Plasma lipid profiling (total cholesterol, triacylglyceride, high density lipoprotein (HDL), Low density lipoprotein (LDL) was carried out and the liver and kidney of the rats were examined for histopathological changes. The results showed that administration of aqueous seeds extract of Citrullus vulgaris restored the levels of the plasma enzymes, blood proteins, urea and creatinine as well as the levels of electrolytes close to normal control levels which were significantly altered by caffeine intoxication, Photomicrographs sections of the liver and kidney showed that the aqueous seeds extract of Citrullus vulgaris was able to repair damage to organs caused by caffeine-intoxication. The study concluded that the aqueous seeds extract of C. vulgaris possesses ameliorative potential against hepatic and renal damage that arises from caffeine-intoxication.
      PubDate: 2024-01-10
      DOI: 10.9734/ejmp/2024/v35i11174
      Issue No: Vol. 35, No. 1 (2024)
       
  • Phytochemical Profile, Acute Toxicity, Antioxidant and Anti-inflammatory
           Activity of Hydroethanolic Extracts from Odontonema strictum (Nees) Kuntze
           (Acanthaceae) Root and Stem

    • Authors: Nitiema Mathieu, Belemnaba Lazare , Ouedraogo Windingoudi Rimwagna Christian, Belemlilga Bonewendé Mohamed, Ouedraogo Salfo , Koala Moumouni , Traore Aristide, Ahounou/Aïkpe Judith Fifamin, Ouedraogo Noufou, Kini Bondo Félix, Ouedraogo Sylvin
      Pages: 15 - 25
      Abstract: Background: The leaves of Odontonema strictum (Nees) Kuntze (Acanthaceae), a decorative plant native to Latin America, are used to treat hypertension in alternative medicine. However, the other parts of the plant have not yet been investigated for their antihypertensive properties. Aims: Our study aimed to investigate phytochemical groups with antihypertensive potential, antioxidant and anti-inflammatory properties, and the safety of using stems and roots hydroethanolic extracts. Methodology: Phytochemical screening by HPTLC and determining flavonoids and total polyphenols were carried out. The antioxidant activity was evaluated using ABTS, FRAP, DPPH, and LPO methods. The inhibitory activity of Phospholipase A2 and 15-lipoxygenase was determined. Finally, acute oral toxicity was carried out on female mice NMRI. Results: The hydroethanolic extracts of Odontonema strictum root (HE_ROS) and stem (HE_SOS) contain tannins, sterols, triterpenes, flavonoids, and saponosides. HE_SOS gave the highest levels of flavonoids (23.69±1.10 mg QE/g) and total phenolics (64.15±4.02 mg TAE/g. The two hydroethanolic extracts had antioxidant activity, with HE_ROS being the best. However, these activities were lower than Trolox (p<0.05). The extracts have a moderate inhibitory effect on 15-lipoxygenase and Phospholipase A2. Finally, HE_ROS and HE_SOS are practically non-toxic when administered once orally. Conclusion: This study provided scientific data and could justify the use of Odontonema strictum in the treatment of hypertension.
      PubDate: 2024-02-16
      DOI: 10.9734/ejmp/2024/v35i11175
      Issue No: Vol. 35, No. 1 (2024)
       
 
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