 Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z | | The end of the list has been reached or no journals were found for your choice. |
|
|
- Effects of the Aqueous Extract of the Rhizomes of Zingiber officinale
(Ginger) on Sexual Parameters in Female Wistar Rats
Authors: Peneme B. M. L., Akassa H., Ondélé R., Backala Lanzah A., Etou Ossibi A. W., Abena A. A.
Pages: 1 - 11
Abstract: The rhizome of Zingiber officinal (Ginger) is widely consumed as a juice and spice in the Congo, and is also used in the treatment of various pathologies. The aim of this study was to evaluate the effects of Ginger on the reproductive function of the rat. Four batches of four female rats each received the aqueous rhizome extract of Zingiber officinal (Ginger) at doses of 300 and 600 mg/kg, 17β-estradiol at a dose of 1 mg/kg and distilled water, orally for 14 days. Acute toxicity was previously assessed in mice. The results of the acute toxicity study at a dose of 5000 mg/kg of each extract showed no signs of toxicity in mice. Pharmacological tests with rats showed that aqueous ginger extract non-significantly increased and decreased rat body weight at 300 and 600 mg/kg respectively. The 600 mg/Kg dose blocked the sexual cycle at the estrus stage and lowered plasma estradiol levels. Whereas the 300 mg/kg dose increases plasma estradiol levels with a more or less regular sexual cycle. Chemical screening of this extract revealed the presence of flavonoids, tannins, anthraquinones and steroids.
PubDate: 2023-10-25
DOI: 10.9734/ejmp/2023/v34i101161
Issue No: Vol. 34, No. 10 (2023)
- You Are What You Eat: Preventive Roles of Antioxidant Phytochemicals on
Age-related Eye Diseases
Authors: John E. Moyegbone, Eghonghon E. Onoikhua, Favour A. Fregene, Kingsley N. Jacob, Israel O. Efejene, Edmond I. Anowa, Omatseye A. Akuirene, Emmanuel E. Agege, Joseph O. Odoko, Ezekiel U. Nwose
Pages: 12 - 25
Abstract: Aim: What we eat plays a vital role in human health with no exception to the eye which results to either good or poor vision. This review aimed at determining how what we eat affect age-related eye diseases and the role of antioxidants in phytochemical compound in preventing age-related eye diseases. Study Design: A non-systematic review and evaluation of published literatures was done through web search engines such as PubMed and Google Scholar using Mendeley reference library for citation. Methodology: A total of 48 articles were reviewed using the key words such as ‘’you are what you eat,’’ Age-related eye diseases, Antioxidants, Phytochemical compounds, Oxidative Stress and Free Radicals Results: Increased consumption of energy-dense foods such as refined grains, processed meats, added sugar and saturated fatty foods might increase the risk of obesity, insulin resistance, chronically elevated blood glucose, chronic systemic inflammation, oxidative stress, and increased protein damage leading to initiation and progression of systemic diseases such as diabetes, hypertension, heart related diseases, as well as age-related eye diseases such as cataract, glaucoma, diabetic retinopathy, and macular degeneration. Findings also showed that many botanical compounds such as curcumin, lutein and zeaxanthin, ginseng, and many more, present in food exhibit strong antioxidative, anti-inflammatory, and antiapoptotic properties that helps in ameliorating the destructive roles of oxidative stress. Conclusion: Phytochemicals with proven antioxidant and anti-inflammatory activities, such as carotenoids and polyphenols, could be of benefit in preventing age-related eye diseases. Consumption of products containing these phytochemicals is recommended to provide noninvasive alternatives for protection, prevention and treatments of the major systemic and age-related eye diseases.
PubDate: 2023-11-18
DOI: 10.9734/ejmp/2023/v34i101162
Issue No: Vol. 34, No. 10 (2023)
- Phytochemical Screening, Antioxidant Activity and Cytotoxicity of four
Medicinal Plants for Antidiabetic Purposes Used in the Ivorian
Pharmacopoeia
Authors: Philippe Kessé N’da , Syndoux Dembélé, Emmanuel N’dri Koffi , Emile Kouassi Bebgin , Augustin Amissa Adima
Pages: 26 - 41
Abstract: Aims: This study aims to investigate the phytochemical profile, antioxidant activity and cytotoxicity of aqueous extracts from four plants used in the Yamoussoukro district (Côte d'Ivoire) for the treatment of diabetes. Methodology: Secondary metabolites of four plants (Alchornea cordifolia, Ocimum gratissimum, Tetrapleura tetraptera and Vernonia colorata) were carried out by phytochemical screening using appropriate reagents. Polyphenol and tannin contents were determined using the Folin- ciocalteu colorimetric method. The antioxidant activity of the various extracts was then assessed in vitro using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) assay. Acute toxicity was also assessed by administering extracts orally to mice in single increasing doses. Hypoglycemic and antihyperglycemic activities were determined by monitoring blood glucose levels in mice after administration of the extracts. Results: Phytochemical screening revealed the presence of polyphenols, particularly flavonoids, as well as alkaloids, saponosides, terpenes and sterols in all extracts. The highest total flavonoid content was obtained with the V. colorata extract (58.10 mg/g QE). The A. cordifolia extract had the highest content of total polyphenols (57.56 ± 2.34 mg/g GAE) and total tannins (0.84 ± 0.02 mg/g TAE). Also, the highest antioxidant capacity (0.4190 mg/mL) was observed with the A. cordifolia extract, as well as good hypoglycemic activity at a dose of 300 mg/kg BW. In addition, all the extracts studied had a lethal dose greater than 5000 mg/kg BW. Conclusion: These results show that the plant extracts studied contain several secondary metabolites responsible for their good antioxidant capacities. What's more, the plants studied have good anti-diabetic activity and are non-toxic by the oral route. This could justify their use in traditional medicine to combat diabetes.
PubDate: 2023-11-22
DOI: 10.9734/ejmp/2023/v34i101163
Issue No: Vol. 34, No. 10 (2023)
- Exploring the Influence of Moringa oleifera Leaves Extract on the Shelf
Life of Ground Beef during Refrigerated Storage
Authors: Lucy J. Mwankunda , Frida Nyamete , Beatrice Kilima
Pages: 42 - 52
Abstract: Consumers nowadays are becoming more aware of the importance of using meat products containing safe and natural additives. Hence, using natural food additives to extend the shelf life of meat along with delaying microbial growth is important. Given the increasingly popular view of Moringa oleifera leaves as a traditional remedy a study was designed to investigate the antimicrobial effect of Moringa oleifera leaves aqueous extract on grounded meat. The study evaluated the physico-chemical, microbial, and organoleptic qualities of ground beef treated with, 0.5%1%, 1.5%, and 2% levels of aqueous solution of extract of drumstick (Moringa oleifera) leaves during refrigerated storage at 4 ◦C. The meat samples treated with 1.5% crude extract of drumstick leaves significantly (P<0.05) improved meat pH, juiciness, texture, flavor, taste, and overall acceptability scores as compared to control and other treated samples. Microbial load in terms of Aerobic Plate Count (APC) was found to be decreased significantly (P< 0.05) in treated samples which 2% treatment was more effective. The lightness (L*), redness (a*) yellowness (b*) values significantly decrease which 2% has decrease more. The pH of ground beef showed a slight increase during storage but Moringa extract does not significantly affect the pH of the meat.
PubDate: 2023-11-25
DOI: 10.9734/ejmp/2023/v34i101164
Issue No: Vol. 34, No. 10 (2023)
- Effect of the Combination of Stem Bark Extract of Parkia biglobosa (Jacq)
Benth and Certain Antibiotics against Some Organisms of Medical Importance
Authors: Darlington Ugochukwu Onele , Ememobong Gideon Asuquo , Chinweizu Ejikeme Udobi, Chibuzor Nneamaka Nwosu, Edet Effiong Akpanenang , Esther Chinonye Ugwoke
Pages: 53 - 62
Abstract: Plant-derived compounds are known to exhibit a direct antibacterial activity and or an indirect activity as antibiotic resistance modifying compounds, and when combined with antibiotics, increased effectiveness may be observed. In this study, effort was directed towards combining the aqueous fraction of the methanol extract of the stem bark of Parkia biglobosa with some antibiotics to observe their combination effects on some organisms of medical importance. The minimum inhibitory concentration (MIC) of the extract and test antibiotics was determined using the checkerboard assay. Combination studies were carried out to ascertain the activities of the combinations against test organisms using the rate of kill assay and checkerboard assay. Results obtained confirmed interaction between the plant extract and the test antibiotics. It specifically confirmed synergistic interaction between Tetracycline, Erythromycin and Nalidixic acid respectively and the extract against Pseudomonas aeruginosa and Escherichia coli. Results obtained proved that in the search for alternative ways of combating bacterial infections, combination of plant extract with antibiotics could boost effectiveness and the aqueous fraction of the methanol extract of Parkia biglobosa is a possible candidate for this purpose against two of the tested organisms.
PubDate: 2023-12-01
DOI: 10.9734/ejmp/2023/v34i101165
Issue No: Vol. 34, No. 10 (2023)
|
Open Access journal
