Authors:A. Idi, M. K. Atiku, A. J. Alhassan, I. U. Muhammad Pages: 1 - 9 Abstract: This study was aimed at studying the effect of solvents (n-hexane, chloroform and methanol) fractions of Cucurbita maxima (pumpkin) cuticular lipids on metabolic biomarkers of cardiovascular disease using L-NAME induced hypertensive rats. A total of thirty-six (120-150 g) albino rats were randomly selected and placed into twelve groups of three rats each were used for this study. Each rat was weighed and tagged and thereafter weighed weekly for five weeks of the experiment. Rats were induced with hypertension using 40mg/Kg body weight/24hours. Other rats were placed on normal feeds and water while biomarkers were assayed and recorded on weekly basis. Group I served as normal control, Group II were hypertensive control, Group III were induced with hypertension and administered with standard drug while Groups IV-XII were induced with hypertension and administered with varying doses of n-hexane, chloroform and methanol fractions. A slight alteration on metabolic biomarkers between the normal control group and hypertensive control group was recorded, which was reversed by the administration of methanol fraction. Thus, cuticular lipids from Cucurbita maxima might have some anti-hypertensive potentials. PubDate: 2022-07-21 DOI: 10.9734/ejmp/2022/v33i830481
Authors:Tauanne Fernanda dos Santos, Emillene de Holanda Colli, Diego Francisco Degiovanni Benitez, Maria Eugênia de Lima Pinheiro, Barbara dos Reis Dal Lago Rodrigues, Silvio Rodrigo Arevalos Davalos, Maria Borges Tavares, Celso Dal Lago Rodrigues Neto, Camila Borges Siqueira Campos, Fernando Araújo de Oliveira, Gleyson Murillo Aguilera Moraes, Mellânia Rodrigues Goveia, Marco Antônio de Souza Borges Tavares Pages: 10 - 15 Abstract: This is a literature review with the objective of presenting scientific evidence about the therapeutic importance of the use of Anacardium humile for the treatment of infected skin wounds. Retrospective and analytical study carried out from 1999 to 2021, in the Bireme, UpToDate, Pubmed and Scielo databases. The association of the descriptors “Phytotherapy” was used; “Cerrado and Pantanal Plants”; “Wounds contaminated by bacteria”; “elastic fibers”. Of the 248 articles analyzed, 36 were included in the review because they met the inclusion criteria. Among the results, it was evidenced that the conventional treatments, although effective (the gold standard being Sulfadiazine 1% silver), present toxicity to human keratinocytes and fibroblasts, with this, it is concluded that further research will be necessary to prove the effectiveness of new treatment options or association of herbal medicines with treatment. PubDate: 2022-08-03
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