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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
Showing 1 - 15 of 15 Journals sorted by number of followers
Journal of Palliative Medicine     Hybrid Journal   (Followers: 52)
Cognitive Neuroscience     Hybrid Journal   (Followers: 32)
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 24)
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 18)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
BMC Complementary Medicine and Therapies     Open Access   (Followers: 17)
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
International Journal of Yoga     Open Access   (Followers: 17)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 16)
Acupuncture in Medicine     Hybrid Journal   (Followers: 16)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 16)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 14)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 12)
Alternative & Integrative Medicine     Open Access   (Followers: 10)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 10)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 9)
Advanced Herbal Medicine     Open Access   (Followers: 8)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 8)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 8)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 6)
Alternative Medicine Studies     Open Access   (Followers: 6)
Asian Journal of Plant Pathology     Open Access   (Followers: 5)
Synfacts     Hybrid Journal   (Followers: 5)
Medical Acupuncture     Hybrid Journal   (Followers: 5)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Fitoterapia     Hybrid Journal   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Ayurveda Case Reports     Open Access   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 4)
Journal of Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Chinese Medicine     Open Access   (Followers: 3)
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 3)
Yoga Mimamsa     Open Access   (Followers: 3)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Ancient Science of Life     Open Access   (Followers: 3)
Integrative Medicine Research     Open Access   (Followers: 3)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 3)
Journal of Ayurveda     Open Access   (Followers: 3)
Indian Journal of Ayurveda and lntegrative Medicine Klue     Open Access   (Followers: 3)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 3)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 2)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 2)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 2)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 2)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Alternative Medicine     Full-text available via subscription   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Ginseng Research     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine and Culture     Open Access   (Followers: 1)
Muller Journal of Medical Sciences and Research     Open Access   (Followers: 1)
Médecine Palliative     Full-text available via subscription   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Journal of Fasting and Health     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 1)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Anales de Hidrología Médica     Open Access   (Followers: 1)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 1)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Integrative Medicine & Therapy     Open Access  
Journal of Complementary and Alternative Medical Research     Open Access  
Journal of Health Sciences Scholarship     Open Access  
World Journal of Traditional Chinese Medicine     Open Access  
Natural Volatiles & Essential Oils     Open Access  
Natural solutions     Full-text available via subscription  
Traditional Medicine Journal     Open Access  
World Journal of Acupuncture - Moxibustion     Full-text available via subscription  
Indian Journal of Research in Homoeopathy     Open Access  
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Journal of Traditional Chinese Medical Sciences     Open Access  
Experimental and Therapeutic Medicine     Full-text available via subscription  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
Traditional & Kampo Medicine     Full-text available via subscription  
Research Journal of Pharmacognosy     Open Access  
Intas Polivet     Full-text available via subscription  
Global Journal of Traditional Medicine     Open Access  
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access  
Ipnosi     Full-text available via subscription  
OA Alternative Medicine     Open Access  
Herba Polonica     Open Access  
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription  
International Journal of High Dilution Research     Open Access  
Revista Internacional de Acupuntura     Full-text available via subscription  

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Journal Cover
Evidence-based Complementary and Alternative Medicine
Journal Prestige (SJR): 0.683
Citation Impact (citeScore): 2
Number of Followers: 24  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1741-427X - ISSN (Online) 1741-4288
Published by Hindawi Homepage  [339 journals]
  • Crocus sativus L. Stigmas, Tepals, and Leaves Ameliorate
           Gentamicin-Induced Renal Toxicity: A Biochemical and Histopathological

    • Abstract: The most costly spice in the world, Crocus sativus L. (C. sativus), has been used for more than 3,000 years. It has various beneficial applications in a range of fields, including aromas, colorants, and medications, but its usefulness as a food flavoring and coloring ingredient is the highest. Large quantities of by-products from the processing of saffron are typically thrown as unwanted bio-residues. This study’s goal was to assess and compare the nephroprotective effects of hydroethanolic extracts of C. sativus stigmas, tepals, and leaves on gentamicin (GM)-induced nephrotoxicity in rats. For that, we used a biochemical and histological investigation to propose new pharmaceutical valorizations. Based on the biochemical and histological analyses, it is concluded that all the studied parts of C sativus showed a renoprotective effect. Markedly, tepals revealed the most significant reduction of relative liver weight , water intake , plasma creatinine , plasma urea , plasma uric acid , urinary protein and albumin , and renal malondialdehyde (MDA) . In addition, C. sativus tepals caused a significant increase in body weight , urinary creatinine , creatinine clearance , and urinary urea compared with the gentamicin untreated (GM) group. This is confirmed by the histopathological study which shows that treatment with stigmas, tepals, and leaves preserved kidney morphology at the glomerular and tubular cell level. The studied extracts exhibit good recovery potential for nephrotoxicity induced by gentamicin. In order to create potent dietary supplements or phytomedicines, it would also be very interesting to confirm these actions through clinical research.
      PubDate: Sat, 01 Oct 2022 11:20:00 +000
  • Study on the Potential Mechanism of Semen Strychni against Myasthenia
           Gravis Based on Network Pharmacology and Molecular Docking with
           Experimental Verification

    • Abstract: Background. Semen Strychni (SS) is an effective Chinese medicine formula for treating myasthenia gravis (MG) in clinics. Nonetheless, its molecular mechanism is largely unknown. Objective. Using network pharmacology, molecular docking, and experimental validation, we aim to identify the therapeutic effect of SS on MG and its underlying mechanism. Methods. The main ingredients of SS and their targets and potential disease targets for MG were extracted from public databases. The protein-protein interaction (PPI) network was constructed using the STRING 11.0 database, and Cytoscape was used to identify the hub targets. In addition, Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to identify molecular biological processes and signaling pathways. Then, AutoDock Via conducted molecular docking. The experimental autoimmune myasthenia gravis (EAMG) model in female Lewis rats, quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and enzyme-linked immunosorbent assay (ELISA) were performed to confirm the effect and mechanism of SS on MG. Results. The following active compounds and hub targets were identified by screening and analyzing: isobrucine, vomicine, (S)-stylopine, strychnine, brucine-N-oxide, brucine and AKT1, MAPK1, MAPK14, CHRM1, ACHE, and CHRNA4. KEGG enrichment analyses indicated that the cholinergic synapse and neuroactive ligand-receptor interaction signaling pathway may be necessary. The results of molecular docking revealed that the main active ingredients bind well to the hub targets. In vivo experiments proved that SS could improve the weight loss and Lennon scores in the EAMG model. Experiments in molecular biology showed that SS could treat MG by affecting the cholinergic synapse through the respective antibody, receptor, and key enzymes in the cholinergic pathway. Conclusion. This study provided a preliminary overview of the active constituents, primary targets, and potential pathways of SS against MG. SS ameliorated EAMG by regulating the cholinergic synaptic junction.
      PubDate: Sat, 01 Oct 2022 11:05:00 +000
  • The Neuroprotective Potential of Endophytic Fungi and Proposed Molecular
           Mechanism: A Current Update

    • Abstract: Millions of people are affected by neuronal disorders that are emerging as a principal cause of death after cancer. Alzheimer’s disease, ataxia, Parkinson’s disease, multiple system atrophy, and autism comprise the most common ones, being accompanied by loss of cognitive power, impaired balance, and movement. In past decades, natural polyphenols obtained from different sources including bacteria, fungi, and plants have been utilized in the traditional system of medicine for the treatment of several ailments. Endophytes are one such natural producer of secondary metabolites, namely, polyphenols, which exhibit strong abilities to assist in the management of such affections, through modifying multiple therapeutic targets and weaken their complex physiology. Limited research has been conducted in detail on bioactive compounds present in the endophytic fungi and their neuroprotective effects. Therefore, this review aims to provide an update on scientific evidences related to the pharmacological and clinical potential along with proposed molecular mechanism of action of endophytes for neuronal protection.
      PubDate: Sat, 01 Oct 2022 04:50:00 +000
  • Efficacy and Safety of Wuling Powder in the Treatment of Patients with
           Diabetic Nephropathy: A Systematic Review and Meta-Analysis

    • Abstract: Background. Wuling powder is a classical formula of traditional Chinese medicine (TCM), which is extensively applied to treat diabetic nephropathy (DN). However, there are no related reports on systematically evaluating the efficacy of Wuling powder in the treatment of DN. Targeted at this, this study was developed. Materials and Methods. This study systematically searched related articles from nine databases, including PubMed, Cochrane Library, Embase, Web of Science, China Knowledge Infrastructure (CNKI), China Biomedical CD-ROM (Sino Med), Wanfang database, Vipers database (VIP), and the China Clinical Trials Registry website. The randomized controlled trials (RCTs) involving Wuling Power to treat DN were included, which were published from the established data of the above databases to March 2022. In addition, the language of the studies was not restricted. Studies were meta-analyzed using the RevMan 5.4 software given in the Cochrane Collaboration Network. The treatment efficacy was measured using the weighted mean differences (WMD) and 95% confidence intervals (CI). Results. 24 studies were included for the final analysis. 24 h urine volume (WMD = 357.95; 95% CI [322.83, 393.06], ), 24 h urine protein quantification(24 h UPQ) (WMD = −1.30; 95% CI [−1.82, −0.78], ), serum creatinine (Scr) (WMD = −10.17; 95% CI [−11.13, −9.21], ), blood urea nitrogen (BUN) (WMD = −1.62; 95% CI [−2.30, −0.93], ), urinary albumin excretion rate (UAER) (WMD = −24.73; 95% CI [−35.46, −13.99], ), fasting blood glucose (FBG) (WMD = −0.63.95% CI [−0.97, −0.30], p = 0.002), glycated hemoglobin (WMD = −0.11; 95% CI [−0.30, 0.08], ), total cholesterol (TC) (WMD = −0.63; 95% CI [−1.23, −0.04], ), triglycerides (TG) (WMD = −0.46. 95% CI [−0.70, −0.23], ), high-density lipoprotein cholesterol (HDL-C) (WMD = −0.32; 95% CI [0.03, 0.62], ), low-density lipoprotein cholesterol (LDL-C) (WMD = −0.57; 95% CI [−0.77, −0.37], ), and total effective rate (TER) (response ratio (RR) = 1.40; 95% CI [1.32, 1.48]; ) were concluded. The Wuling powder in the treatment of DN was statistically significant in all the above outcome indicators, and the efficacy of the treatment group was better than that of the control group. Conclusion. The results of this study provided evidence for the clinical application of Wuling powder to treat the DN, but it had to be further validated in higher-quality clinical studies.
      PubDate: Fri, 30 Sep 2022 15:50:00 +000
  • Influence of the Clinical Nursing Pathway on Nursing Outcomes and
           Complications of Cervical Carcinoma Patients Undergoing Chemotherapy via

    • Abstract: Background. Cervical Carcinoma (CC) is the second most common cause of death in women, with most patients being diagnosed at an advanced stage. The conventional treatment for CC, with a long chemotherapy treatment cycle, is less than satisfactory and will cause serious damage to the patient’s blood vessels. Objective. To analyze the impact of the clinical nursing pathway (CNP) on the incidence of complications and adverse prognosis in patients undergoing chemotherapy for CC via peripherally inserted central catheters (PICC). Materials and Methods. This study enrolled 157 CC patients who underwent PICC chemotherapy in the Shaanxi Provincial Cancer Hospital between March 2017 and April 2020 and assigned them between the two groups according to different nursing interventions. Ninety-three patients treated with CNP intervention were included in the research group (RG), and sixty-four cases treated with the routine nursing intervention were included in the control group (CG). The self-care ability and intervention satisfaction of patients were assessed using the self-care ability scale and the intervention satisfaction questionnaire, respectively, both developed by our hospital. The complication rate was observed in both cohorts, and the adverse prognosis of patients was statistically analyzed. Finally, an assessment was made on the patients’ quality of life (QOL) using the quality of life questionnaire core 30 (QLQ-C30). Results. Higher scores of self-management information, catheter nursing ability, self-care compliance, and abnormal situation management were determined in RG after the nursing intervention. RG also outperformed CG in the overall incidence rates of complications and poor prognosis. Moreover, RG presented statistically higher nursing satisfaction and QLQ-C30 scores than CG after the nursing intervention. Conclusion. CNP has a significant nursing effect on patients with CC treated with PICC chemotherapy, which can not only reduce the incidence of postchemotherapy complications but also improve patient prognosis, satisfaction, and life quality, with the value for clinical promotion.
      PubDate: Fri, 30 Sep 2022 15:20:02 +000
  • Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp.
           Cuspidata (Indian Olive) Seed Extracts

    • Abstract: The aim of the present study was to evaluate the antioxidant and antidiabetic potential of Indian olive seed extracts. Plant seeds were sequentially extracted with n-hexane, chloroform, methanol, and water. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging and alpha-amylase inhibitory activities of extracts were carried out. Olea europaea methanolic extract (MEOE) and aqueous extract (AEOE) were orally administered to normoglycemic and alloxan-treated diabetic rats so as to determine their hypoglycemic effect. High-performance liquid chromatography (HPLC) analysis showed gallic acid, ferulic acid, quercetin, and vanillic acid in MEOE. It was found that the methanolic and aqueous extracts exhibited the maximum DPPH and alpha-amylase inhibition activities, respectively. MEOE and AEOE exerted a significant decline in the fasting blood sugar in diabetic animals (); however, they did not cause hypoglycemia in nondiabetic animals. Treatment with MEOE and AEOE reduced the aggravated liver and kidney function biomarkers. Aggravated levels of oxidative stress biomarkers including superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and malondialdehyde (MDA) were restored by treatment with MEOE. Moreover, MEOE improved the count of islets of Langerhans in the pancreas, fatty changes, and enlarged sinusoidal spaces in the liver and necrosis of the glomerulus and tubular cells of the kidney in diabetic rats. This study showed that the African olive seed extract effectively managed experimental diabetes and restored the normal functions and histology of the liver and kidney in diabetic rats through the reduction of oxidative stress.
      PubDate: Fri, 30 Sep 2022 15:20:01 +000
  • Effect of Antioxidant-Rich Moringa Leaves on Quality and Functional
           Properties of Strawberry Juice

    • Abstract: Moringa oleifera and strawberry are cultivated extensively worldwide and are divinely blessed with an enormous amount of nutritional and medicinal constituents, such as vitamin C, vitamin E, iron, potassium, and phenolic antioxidants that play a pivotal role in treating, confining, and preventing diabetes and many kinds of cancer. The focus of the study is to develop different samples of highly acceptable ready to serve (RTS) Moringa strawberry juice blend by underutilizing Moringa and strawberry juice in different proportions. Moringa oleifera’s bitter taste and green color steeply limits its acceptability and counter this drawback utilized with strawberry juice. The physicochemical analysis of blended juice was performed to investigate the suitability and keeping quality of the juice mixture. The collected data signify that pH titratable acidity (TA) and total soluble solids (TSS) the slight modification after the inclusion of Moringa juice extract and throughout the storage. The Moringa treatment positively improved the total phenolic content (TPC), antioxidant, and vitamin C from 12 to 49.17 mg GAE/100g, 61.41 to 87.69%, and 64.03 to 86.65 mg/100 mL, respectively, but there was a slight decline in antioxidant quantity while stored under refrigerated conditions for one month. An assimilative trend was noticed in TPC and vitamin C, which collapsed from 49.17–36.32 mg GAE to 86.65–79.19 mg, respectively. In accordance with sensory analysis T2 (90% strawberry juice and 10% Moringa extract), the juice blend was rated best in context to flavor, color, and taste. This juice blend proved to be greatly effective especially for children suffering from malnutrition as well as women to counter with its appreciable number of nutritional constituents.
      PubDate: Fri, 30 Sep 2022 15:05:00 +000
  • Evaluation of Ulcer Protective Activity of Morus alba L. Extract-Loaded
           Chitosan Microspheres in Ethanol-Induced Ulcer in Rat Model

    • Abstract: Due to an unhealthy lifestyle, gastric ulcers have become a very common disease these days. Moreover, the side effects linked with the prolonged use of conventional treatments have shifted the paradigm towards herbal therapies. The leaves of Morus alba L. (Family-Moraceae) have been traditionally used for a large number of metabolic diseases. In the present research, we focused on the development of chitosan microspheres using extracts of leaves of Morus alba L. and their evaluation for gastroprotective efficacy against ethanol-induced ulcers in experimental rats. The process of development of M. alba extract microsphere (MEM) is also optimized using the Box-Behnken design. The formulation was prepared at optimized conditions (chitosan concentration (1.66% w/w), volume of glutaraldehyde (4.69 mL), and stirrer rotation per minute, RPM, 854.8), and the percentage yield (Y1) of the resulted microspheres is ∼95% with an encapsulation efficiency (EE) of (Y2(rutin)) ∼86%, Y2(quercetin)) ∼85%, and particle size (Y3) of ∼40 µm. The MEM prepared at optimized conditions can also be characterized for various parameters to ensure the uniformity of parameters. Also, the drug release studies indicated that the percentage release of rutin and quercetin from MEM was enhanced as compared to M. alba extract (ME) alone. Furthermore, in vivo analysis of the antiulcer potential of pretreatment with ME and MEM (500 mg/kg p.o.) in rats indicated that mucosal lesions, gastric juice volume, and total acidity were significantly altered as compared to ethanol-treated animals. Histopathology of tissue sections also confirmed the protection of gastric mucosa on pretreatment with MEM at 500 mg/kg p.o. On the basis of these findings, we can conclude that prepared microspheres can be used to develop a sustained release formulation of extract for the management of gastric ulcers. However, additional research is needed to establish the specific mechanisms of M. alba’s antiulcer efficacy.
      PubDate: Fri, 30 Sep 2022 14:50:00 +000
  • Stachys pilifera Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis
           in Rats through the Antioxidant Pathways

    • Abstract: Background and Aim. Fibrosis of the lungs is an interstitial lung disease whose diagnosis and treatment are not well-established. Stachys pilifera Benth. (Lamiaceae) has been proven to have antioxidant and anti-inflammatory properties. This study was performed to determine the effect of S. pilifera extract on bleomycin-induced pulmonary fibrosis in rats. Methods. In this experimental study, 35 male Wistar rats (120–180 g) were divided into five groups (n = 7) as follows: intratracheal instillation of bleomycin (BLM, 7.5 IU/kg) was administered to group II. The third and fourth groups received BLM plus Stachys pilifera hydroalcoholic extract (SPHE) (300 mg/kg/day, gavage). Vitamin E (500 mg/kg/day, gavage) was given to group V in addition to BLM. After 14 days, the animals were euthanized to assess biochemical parameters and lung histopathology. Malondialdehyde (MDA), nitric oxide (NO), total thiol (TSH), and glutathione (GSH) levels were measured. In addition, hydroxyproline (HYP) levels along with histological changes in lung tissue were also assessed. Results. MDA, NO, and HYP elevations induced by BLM toxicity were significantly inhibited by SPHE (300 and 600 mg/kg), and Vit E. SPHE also significantly increased GSH and TSH levels in comparison to the BLM group.HPLC analyses showed the presence of thymol (55.47 ng/mL) and carvacrol (109.91 ng/mL) in SPHE as potential bioactive phenolic compounds. Conclusion. The results suggest that SPHE alleviates the development of BLM-induced pulmonary fibrosis by inhibiting the proliferation of fibroblasts mediated by antioxidant pathways. Other mechanisms underlying this Effect of SPHE need to be clarified through further research.
      PubDate: Fri, 30 Sep 2022 14:50:00 +000
  • Nanoformulation of Tetrapyrroles Derivatives in Photodynamic Therapy: A
           Focus on Bacteriochlorin

    • Abstract: Photodynamic therapy (PDT) is a well-known remedial treatment for cancer, infections, and various other diseases. PDT uses nontoxic dyes called photosensitizers (PS) that are activated in visible light at the proper wavelength to generate ROS (reactive oxygen species) that aid in killing tumor cells and destroying pathogenic microbes. Deciding a suitable photosensitizer is essential for enhancing the effectiveness of photodynamic therapy. It is challenging to choose the photosensitizer that is appropriate for specific pathological circumstances, such as different cancer species. Porphyrin, chlorin, and bacteriochlorin are tetrapyrroles used with proper functionalization in PDT, among which some compound has been clinically approved. Most photosensitizers are hydrophobic, have minimum solubility, and exhibit cytotoxicity due to the dispersion in biological fluid. This paper reviewed some nanotechnology-based strategies to overcome these drawbacks. In PDT, metal nanoparticles are widely used due to their enhanced surface plasmon resonance. The self-assembled nano-drug carriers like polymeric micelles, liposomes, and metal-based nanoparticles play a significant role in solubilizing the photosensitizer to make them biocompatible.
      PubDate: Fri, 30 Sep 2022 12:50:00 +000
  • miR-28-5p’s Targeting of GAGE12I Inhibits Proliferation, Migration, and
           Invasion of Gastric Cancer in Vitro

    • Abstract: GAGE12I is a tumor metastasis-promoting factor, which can induce gastric cancer cells to invade and migrate. We investigated the effect of miR-28-5p targeting GAGE12I on proliferation, invasion, and migration of human gastric cancer cell lines SGC-7901, AGS, and MGC-803. The expression levels of miR-28-5p and GAGE12I were detected by real-time PCR and western blot, respectively. Cell proliferation, migration, and invasion were measured by MTT and Transwell chamber. The interaction between miR-28-5p and GAGE12I was investigated by bioinformatics analysis and luciferase assay. Results showed that the expression of miR-28-5p in human gastric cancer cell lines was lower than that in normal gastric epithelial cells (). Overexpression of miR-28-5p suppressed cell proliferation, invasion, and migration (). GAGE12I was confirmed as a target of miR-28-5p. Cell proliferation, invasion, and migration were decreased in cells transfected with shGAGE12I compared with those of the scrambled group (). Collectively, miR-28-5p negatively regulated GAGE12I and reduced the proliferation, invasion, and migration of gastric cancer cells.
      PubDate: Fri, 30 Sep 2022 12:20:02 +000
  • Impact of Chinese Herbal Medicine on Glucolipid Metabolic Outcomes in
           Women with Polycystic Ovary Syndrome: A Systematic Review and

    • Abstract: Objective. This investigation was conducted to analyze and evaluate the impact of Chinese herbal medicine on glucolipid metabolism in women with polycystic ovary syndrome (PCOS). Methods. We used manual and computer-aided search methods, and the search scopes included Chinese databases (China National Knowledge Infrastructure, Wanfang, the China Science and Technology Journal Database, and the Chinese Biomedical Literature Database) and English databases (PubMed, Embase, Web of Science, and the Cochrane Library). We searched these eight databases for randomized controlled trials investigating the effects of Chinese herbal medicine on glucolipid metabolism in women with PCOS, with the retrieval deadline being June 2021. Two reviewers screened, selected, and extracted data and verified the results independently. The NoteExpress software was used to manage and screen the literature, the risk of bias assessment tool was used to evaluate the methodological quality of the included studies, and the RevMan 5.4 software was used for meta-analysis. Results. A total of 13 trials were included, including 825 patients with PCOS. Because the drugs used in the control group were different, we divided the results into two parts, with four trials using placebo and nine trials using metformin as the control. The results of the meta-analysis showed that fasting insulin (MD = −2.45, 95% CI = [−4.74, −0.17], P = 0.04), 2 h fasting plasma glucose (MD = −0.33, 95% CI = [−0.64, −0.02], P = 0.04), serum total cholesterol (MD = −0.38, 95% CI = [−0.58, −0.18], P = 0.0002), triglycerides (MD = −0.36, 95% CI = [−0.58, −0.14], P = 0.001), and low-density lipoprotein cholesterol (MD = −0.58, 95% CI = [−0.75, −0.41], P 
      PubDate: Fri, 30 Sep 2022 12:20:01 +000
  • Application of Nursing Outcome-Oriented Integrated Zero-Defect Nursing
           Combined with Respiratory Function Training in Long-Term Bedridden
           Patients Undergoing Stroke

    • Abstract: Objective. To explore the application effect of nursing outcome-oriented integrated zero-defect nursing combined with respiratory function training in long-term bedridden patients with stroke. Methods. A total of 120 long-term bedridden patients with stroke were randomly divided into three groups: groups A, B, and C. Group A was given nursing outcome-oriented integrated zero-defect nursing combined with respiratory function training, group B was given nursing outcome-oriented integrated zero-defect nursing, and group C was given routine nursing. Rosenbek aspiration degree classification criteria were used to evaluate the incidence of aspiration; blood oxygen saturation, arterial oxygen partial pressure, and respiratory pressure were compared before and after the intervention. The swallowing function was evaluated by a water swallowing test (WST). The quality of life was assessed using the Generic Quality of Life Inventory-74 (GQOLI-74). Results. After treatment, the Rosenbek aspiration degree of groups A and B were better than those of group C ( 
      PubDate: Fri, 30 Sep 2022 12:20:01 +000
  • Data Mining and Network Pharmacology Analysis of Kidney-Tonifying Herbs on
           the Treatment of Renal Osteodystrophy Based on the Theory of “Kidney
           Governing Bones” in Traditional Chinese Medicine

    • Abstract: Background. Renal osteodystrophy (ROD) secondary to chronic kidney disease is closely associated with osteoporosis and fractures. Based on the theory of “kidney governing bones” in traditional Chinese medicine (TCM), treating bone diseases from the perspective of the kidney has become a basic principle of treating ROD. However, there are many kidney-tonifying herbs and their mechanisms of treating ROD are not clear. Therefore, our study intends to use data mining and network pharmacology to study the commonly used kidney-tonifying herbs, as well as their active ingredients and mechanisms of treating ROD. Methods. We established a clinical ROD database by searching PubMed, CNKI, and other databases and screened out a core herbal combination of treating ROD. Furthermore, by using databases such as Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and GeneCards, we obtained active ingredients and targets of the core herbal combination and ROD targets. The STRING website and Cytoscape software were then used to obtain information on key active ingredients and key targets. Finally, we conducted GO and KEGG analyses using the Metascape website and molecular docking using the AutoDock Vina software. Results. Our study eventually included 58 prescriptions and 116 herbs of treating ROD. Through data mining, we found that yin-yang-huo, du-zhong, and bu-gu-zhi (YDB) constituted a core herbal combination to treat ROD. Network pharmacology showed that YDB mainly acted on targets such as estrogen receptor alpha through active ingredients such as quercetin by mitogen-activated protein kinase and other signaling pathways. Conclusion. Many ingredients, targets, and pathways are involved in the treatment of YDB for ROD. Specifically, the flavonoids contained in YDB have great potential for ROD treatment.
      PubDate: Fri, 30 Sep 2022 12:20:01 +000
  • The Preventive Effects of Naringin and Naringenin against
           Paclitaxel-Induced Nephrotoxicity and Cardiotoxicity in Male Wistar Rats

    • Abstract: This study assessed the preventive properties of naringin and naringenin on paclitaxel-induced nephrotoxicity and cardiotoxicity in adult male Wistar rats. Intraperitoneal injection of paclitaxel 2 mg/kg body weight, two days/week on the 2nd and 5th days of each week, with or without oral administration of naringin and/or naringenin 10 mg/kg body weight every other day, was continued for six weeks. Treatment of rats with naringin and/or naringenin significantly reversed elevated serum creatinine, urea, and uric acid levels caused by paclitaxel, reflecting improved kidney function. Similarly, heart dysfunction induced by paclitaxel was alleviated after treatment with naringin and/or naringenin, as evidenced by significant decreases in elevated CK-MB and LDH activities. After drug administration, histopathological findings and lesion scores in the kidneys and heart were markedly decreased by naringin and/or naringenin. Moreover, the treatments reversed renal and cardiac lipid peroxidation and the negative impacts on antioxidant defenses via raising GSH, SOD, and GPx. The preventive effects of naringin and naringenin were associated with suppressing oxidative stress and reestablishing antioxidant defenses. A combination of naringin and naringenin was the most efficacious in rescuing organ function and structure.
      PubDate: Fri, 30 Sep 2022 11:35:01 +000
  • MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1

    • Abstract: MicroRNA-641 (miR-641) was significantly decreased in various cancers, but its roles in endometrial cancer (EC) remain unclear. We explored the influences of miR-641 on the EC cells. In our study, the miR-641 expression was reduced in EC cells. Overexpression of miR-641 inhibited viability and proliferation of HEC-1A and HECCL-1 cells by CCK-8 and colony formation assays. Additionally, flow cytometry revealed that overexpression of miR-641 could remarkably promote apoptosis and arrest the cell cycle at the G1 phase of HEC-1A and HECCL-1 cells. Besides, forced expression of miR-641 suppressed the migration and invasion of HEC-1A and HECCL-1 cells as evidenced by wound healing and transwell assay. Moreover, AP1G1 was confirmed as a target gene of miR-641 by StarBase prediction and DLR assay and their expressions were negatively correlated. Overexpression of AP1G1 neutralized the roles of miR-641 mimic on the viability, proliferation, apoptosis, and migration of HEC-1A and HECCL-1 cells. Our findings illustrated that miR-641 was reduced in the EC cells and AP1G1 antagonized the miR-641 mimic-induced inhibition of the EC progression in vitro. Therefore, miR-641 may emerge as an effective molecule for EC treatment.
      PubDate: Fri, 30 Sep 2022 11:35:01 +000
  • The Effect of Tedlar Bags on the Composition of Exhaled Human Breath

    • Abstract: The PVF Tedlar is widely used for gas collection in clinical diagnostics and environmental research. However, sample collection is frequently associated with the degradation, adsorption, or transformation of sensitive chemicals. Here, we explore to what extent the Tedlar bag collection effects the composition of expired breath samples. Collected breath samples were analyzed using the EESI-MS technique after the storage time of 30 min, 1 h, 2 h, 3 h, 4 h, 5 h, and 6 h, respectively. Our results demonstrated the gradual MS signal decay after 3 h storage. The decay rate of 3 h is about 45% and 6 h is about 88%. Therefore, the Tedlar bag is suggested as a reliable breath holder on the time scale of
      PubDate: Fri, 30 Sep 2022 11:35:01 +000
  • Efficacy of Fangfeng Tongsheng Granule Combined with Levocetirizine in the
           Treatment of Chronic Urticaria and Its Effect on Serum Complement, IL-4,
           IgE, and IFN-γ Levels in Patients

    • Abstract: Objectives. To investigate the efficacy of Fangfeng Tongsheng granule combined with levocetirizine in the treatment of chronic urticaria and its effect on serum complement, interleukin (IL)-4, immunoglobulin E (IgE), and interferon-γ (IFN-γ) levels in patients. Methods. A total of 98 patients with chronic urticaria who were admitted to our hospital from July 2021 to March 2022 were selected and divided into random odd-even numbers. The odd numbers were included in the observation group, with a total of 49 cases, and they were treated with Fangfeng Tongsheng granule combined with levocetirizine; the even numbers were included in the control group, with a total of 49 cases and were treated with levocetirizine alone. The two groups of patients were treated continuously for 4 weeks, and the clinical efficacy of the two groups was observed. Before treatment, 2 weeks and 4 weeks after treatment, evaluate the clinical symptom scores of patients such as itching, flushing, wheal, edema, observe the improvement of clinical symptoms of patients, and the changes in Dermatology Life Quality Index (DLQI). Serum complement C3, C4, T lymphocyte subsets CD3+, CD4+, CD8+ levels and CD4+/CD8+ ratio, IL-4, IgE, and IFN-γ levels and the occurrence of adverse reactions in the two groups were calculated and observed. All patients were followed up for 2 months after treatment to observe the recurrence of patients. Results. The scores of clinical symptoms such as wheal, itching, flushing, edema, and attack frequency in the observation group at each time point after treatment were lower than those in the control group (F times were 725.365, 851.521, 936.411, 3943.136, and 2226.147, all (F between-group were 40.642, 102.124, 188.523, 259.291, and 23.92, ); the total effective rate of the observation group was 93.88% (46/49), which was significantly higher than that of the control group, 73.47% (36/49) (χ2 = 7.470, ). The DLQI scores of the observation group at each time point after treatment were lower than those of the control group (F time was 282.214, ;F between-group was 6.546, ). There was no significant difference in serum C4 levels between the two groups at each time point (F time was 1.225, ;F between-group was 0.408, ); serum complement C3, CD3+, and CD4+/the ratio of CD8+ and IFN-γ were higher than those in the control group (F time was 407.352, 107.823, 32.941, and 2354.147, ;F between-group was 40.941, 24.710, 54.982, and 264.921, ); the observation group at each time after treatment the levels of IgE and IL-4 were lower than those of the control group (F time were 373.124 and 395.612, ;F between-group were 21.802 and 62.591, ). The incidence of adverse reactions in the observation group was 12.24% (6/49) compared with 10.20% (5/49) in the control group, which had no significant difference (χ2 = 0.102, ). Both groups were followed up for 2 months after treatment. The recurrence rate in the observation group was 12.24% (6/49), which was lower than that in the control group, which was 32.65% (16/49) (χ2 = 5.861, ).Conclusion. The application of Fangfeng Tongsheng granules combined with levocetirizine in patients with chronic urticaria can effectively improve the clinical symptoms of patients, improve clinical efficacy, reduce the impact of the disease on life, improve the immune status of patients, and reduce the risk of recurrence.
      PubDate: Fri, 30 Sep 2022 11:35:00 +000
  • Cordyceps militaris Carotenoids Protect Human Retinal Endothelial Cells
           against the Oxidative Injury and Apoptosis Resulting from H2O2

    • Abstract: Vision loss is primarily caused by age-related macular degeneration (AMD) due to oxidative retinal pigment epithelial (RPE) cell injury. Carotenoid utilization is deemed a possible strategy for treating AMD. Cordyceps militaris has advantages like immunomodulatory, anti-inflammatory, and antioxidative characteristics. This paper assessed the possible protective influence of carotenoids obtained by isolating and purifying the Cordyceps militaris (CMCT) into human RPE cells (ARPE-19) damaged by hydrogen peroxide (H2O2). The findings demonstrated that CMCT safeguarded the ARPE-19 cells against the damage and apoptosis caused by H2O2 and oxidative stress via Bcl-2 protein upregulation, as well as the expression of Bax and cleaved caspase-3 protein. In addition, CMCT treatment increased cell survival and restricted the generation of H2O2-induced reactive oxygen species (ROS) and the protein expression of NADPH oxidase-1 (NOX1). Additionally, the CMCT treatment of H2O2-induced ARPE-19 cells ameliorated high malondialdehyde (MDA) levels in oxidative stress-induced cells. The catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH) returned to standard levels, which were governed by the higher expression of nuclear Nrf2 protein in the ARPE-19 cells. Moreover, this study showed that CMCT safeguarded the ARPE-19 cells against the damage caused by oxidative stress via its antioxidant activity and antiapoptotic functionality, suggesting the potential therapeutic role of CMCT in AMD prevention and mitigation.
      PubDate: Fri, 30 Sep 2022 11:35:00 +000
  • Mechanism of Yangxin Tongmai Decoction in the Treatment of Coronary Heart
           Disease with Blood Stasis Syndrome Based on Network Pharmacology and
           Molecular Docking

    • Abstract: This study aimed to explore the mechanism of Yangxin Tongmai decoction (YXTMD) in the treatment of coronary heart disease (CHD) with blood stasis syndrome (BSS) using network pharmacology and molecular docking, and to verify these results through clinical trials. The active compounds of YXTMD were identified using the Traditional Chinese Medicine Systems Pharmacology database, and the targets of the active compounds were predicted using the SwissTarget Prediction database. The targets of CHD and BSS were predicted using the GeneCards, OMIM, PharmGKB, TTD, and DrugBank databases. The common targets of “herb-disease-phenotype” were obtained using a Venn diagram, then used Cytoscape software 3.8.2 and its plug-in CytoNCA and STRING database to construct the “herb active compounds-common target” and protein–protein interaction networks. R language software and bioconductor plug-in were used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. AutoDock was used for the molecular docking analysis. Finally, clinical trials were conducted to confirm the results of network pharmacology. Eighty-three active components were obtained, and the core active components were 5,7,4′-trimethoxyflavone, tetramethoxyluteolin, isosinensetin, sinensetin, and 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one. A total of 140 common targets were identified, and the core targets were EGFR, VEGFA, AKT1, STAT3, TP53, ERBB2, and PIK3CA. Biological processes identified by the GO analysis primarily involved wound healing, regulation of body fluid levels, and vascular process in circulatory system. The cellular components were primarily located in the membrane raft, membrane microdomain, and plasma membrane raft. The primary molecular functions were activity of transmembrane receptor protein kinase, transmembrane receptor protein tyrosine kinase, and protein tyrosine kinase. KEGG analysis showed that the PI3K-Akt signaling pathway was closely related to the treatment of CHD with BSS by YXTMD. Molecular docking results showed that the core active components had a good binding activity with the core targets. The clinical trial results showed that YXTMD improved the BSS scores and decreased the serum levels of total cholesterol and low-density lipoprotein cholesterol. Moreover, the levels of PI3k and AKt mRNA were upregulated and the levels of GSK-3β mRNA were downregulated. YXTMD has multicomponent, multitarget, and multipathway effects in the treatment of CHD with BSS, and its mechanism of action may involve activation of the PI3K-AKt signaling pathway, downregulation of GSK-3β, and mediation of in vivo lipid metabolism-based metabolic processes.
      PubDate: Fri, 30 Sep 2022 07:05:00 +000
  • Analysis of the Effectiveness of the Nurse-Led “Outpatient-Ward-Home”
           Management Model in Chronic Kidney Patients

    • Abstract: Objective. To investigate the application and effect of the nurse-led “outpatient-ward-home” management model in the care of patients with chronic kidney disease (CKD). Methods. 120 patients with CKD admitted to our hospital between April 2020 and April 2021 were selected as trial subjects. All patients were divided into experimental and control groups according to the random number table method, with 60 cases in each group. The patients in the experimental group implemented the nurse-led “outpatient-ward-home” management model; the patients in the control group were given routine care and telephone follow-up. The self-rating anxiety scale (SAS), self-rating depression scale (SDS), Pittsburgh Sleep Quality Index (PSQI) score, self-management scores, nutritional status, renal function indicators, and chronic renal failure quality of life scale (QLICD-CRF2.0) were compared between the two groups before and 6 months after the intervention. Results. Before the intervention, there were no statistically significant differences between the control and experimental groups in SAS, SDS, PSQI scores, self-management scores, QLICD-CRF2.0 scores, body mass index (BMI), prealbumin (PAb), albumin (ALB), serum creatinine (Scr), blood urea nitrogen (BUN), and glomerular filtration rate (GFR) levels (). After 6 months of intervention, SAS, SDS, PSQI scores, Scr, BUN, and GFR levels were lower in the experimental group than in the control group; self-management scores, QLICD-CRF2.0 scores, BMI, PAb, and ALB levels were higher in the experimental group than in the control group ().Conclusion. The nurse-led “outpatient-ward-family” intervention model can improve the negative emotions and sleep disorders of CKD patients, enhance patients’ self-management ability, and to a certain extent, slow down the disease process and improve the quality of life.
      PubDate: Fri, 30 Sep 2022 05:05:01 +000
  • Updated Meta-Analysis Assessing Effects of Baduanjin on Cardiopulmonary
           Functions of Patients with Coronary Heart Disease

    • Abstract: Background. Baduanjin is a kind of moderate-intensity aerobic exercise, but its effect on the cardiac rehabilitation (CR) of patients with coronary heart disease (CHD) is controversial. Furthermore, the small sample size of a single study and the inconsistent selection of evaluation indicators among different studies all promote the necessity of conducting a meta-analysis. Objective. This meta-analysis aims to explore whether Baduanjin can effectively improve the cardiopulmonary function in patients with CHD and to assess the extrapolation of the results. Methods. Both English and Chinese databases were used for literature retrieval. The Cochrane Collaboration tool was used to evaluate the methodological quality of the included literature. A weighted mean difference and a 95% confidence interval were used to assess the effects of Baduanjin on cardiopulmonary function based on multiple CR indicators. Cochran’s Q and I2 tests were used for the heterogeneity test. A funnel plot and an Egger test were used to evaluate publication bias. Results. After literature retrieval, a total of 12 literature papers were included in this meta-analysis, but their methodological quality was unsatisfactory. By comparing differences between CHD patients with and without Baduanjin, we found that levels of 6MWT, LVEF, NT-proBNP, VO2, peak VO2, MVV, and VE, AT were significantly improved in the experimental group, but heterogeneity exists among included studies. Results of subgroup analyses were consistent with combined estimates and suggested a significant effect of Baduanjin on LVEF. The Egger test indicated no significant publication bias. Conclusion. Baduanjin is beneficial to CR in CHD patients, but multiple region-based high-quality studies are necessary to verify the results.
      PubDate: Thu, 29 Sep 2022 15:50:01 +000
  • Analysis of Placement Priorities and Nursing Countermeasures of
           Transnasally Inserted Intestinal Obstruction Catheters in Patients with
           Acute Small Bowel Obstruction

    • Abstract: Objective. To explore the placement priorities and analysis of nursing countermeasures of transnasally inserted intestinal obstruction catheters in patients with acute small bowel obstruction (ASBO). Methods. One hundred and three patients with ASBO treated in our hospital from May 2016 to February 2022 were enrolled to this study. Patients who received individual nursing for transnasally inserted intestinal obstruction catheters were considered as the observation group (n = 59) and those who received traditional nursing were regarded as the control group (n = 44). The symptom relief time, daily gastrointestinal decompression, bowel sound recovery time, exhaust, defecation recovery time, and gas-liquid plane disappearance time were compared between both groups. The abdominal pain was evaluated by visual analogue scale (VAS), and the psychology of patients was evaluated by self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Patients’ clinical efficacy and incidence of adverse effects were counted, and quality of life was assessed using the short form 36 (SF-36) health survey questionnaire. Results. In the observation group, the improvement time of clinical symptoms and VAS, SAS, and SDS scores after intubation were lower than those of the control group, while the total clinical treatment efficiency was higher (). As to the adverse effects, the observation group was lower than the control group (). Also, the SF-36 scores were higher than those of the control group in all dimensions ().Conclusion. The individual nursing strategy implemented for the transnasally inserted intestinal obstruction catheter can effectively shorten the recovery of ASBO patients and improve their treatment outcome and prognosis quality of life.
      PubDate: Thu, 29 Sep 2022 15:05:00 +000
  • Pharmacological Effects of Hydrocotyle bonariensis Comm. ex Lam
           (Araliaceae) Extract on Cardiac Activity

    • Abstract: Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific information in the literature. This study aimed essentially to evaluate the potential cardiomodulatory effect of the hydroethanolic extract of Hydrocotyle bonariensis. In other to do so, the hydroethanolic extract of H. bonariensis was studied in vivo on the Wistar rat ECG and then in vitro on the isolated perfused Wistar rat heart using the Langendorff system. The extract was also tested on isolated guinea pig atria kept alive in the organ-specific vessel under physiological conditions similar to those of a living organism. At the cellular level, the effects of the extract were evaluated on the human cardiac sodium current INav1.5 and on the human cardiac pacemaker current If. We noted that the extract caused a decrease in P wave and T wave amplitudes and heart rate and an increase in the duration of the RR interval on the in vivo rat ECG. On the isolated perfused Langendorff heart as well as on the isolated atria, a decrease in the RR interval and in the heart rate was noted. The extract had no effect on human cardiac sodium current, but it did reduce human cardiac pacemaker current. In conclusion, the present study demonstrated that Hydrocotyle bonariensis, a medicinal plant traditionally used to prevent and treat hypertension, has an overall cardiomoderating effect. This effect would contribute to the reduction of blood pressure.
      PubDate: Thu, 29 Sep 2022 12:20:01 +000
  • NEK2 Serves as a Novel Biomarker and Enhances the Tumorigenicity of
           Clear-CellRenal-Cell Carcinoma by Activating WNT/β-Catenin Pathway

    • Abstract: Objective. Currently, cumulative evidence has shown that loss of NEK2 function suppresses tumor growth. However, complete studies on the regulatory role of NEK2 in clear-cellrenal-cell carcinoma (ccRCC) are rarely reported. Methods. The GEPIA database was used for information mining to analyze the gene expression differences between ccRCC tumor and normal tissues. At the same time, we analyzed the protein expression of NEK2 in clinical ccRCC samples and ccRCC cell lines. We detected the effect of NEK2 on the biological behavior of ccRCC at the cell level and further verified the biological effect of NEK2 on ccRCC cells in vivo by nude mouse tumorigenesis experiment. The expression of WNT/β-cateninpathway-related proteins and downstream proteins related to cell function were detected by Western blotting. Results. Using the GEPIA database, we observed that NEK2 expression level in ccRCC tissues was significantly higher than that in normal kidney tissues and was also related to tumor grade. The survival time of patients with ccRCC with high NEK2 expression was shorter than that of patients with low NEK2 expression. Compared with adjacent carcinoma and normal renal tubular epithelial cells, NEK2 levels were highly expressed in ccRCC tissues and ccRCC cell lines. NEK2 interference restrained ccRCC cell growth, migration, and invasion. NEK2 regulated the malignant behavior of ccRCC cells through the WNT/β-catenin pathway. Nude mouse tumorigenesis assay results showed that the transplanted tumors from NEK2 silenced mice grew more slowly and were smaller in size than those from control mice. Conclusions. NEK2 elevation may be associated with poor prognosis in ccRCC, and NEK2 enhances ccRCC cell proliferation, migration, and invasion ability by activating the WNT/β-catenin signaling pathway.
      PubDate: Thu, 29 Sep 2022 12:20:01 +000
  • Identification of CeRNA Regulatory Networks in Atrial Fibrillation Using

    • Abstract: The initiation and maintenance of AF is a complex biological process that is the ultimate manifestation of many cardiovascular diseases. And the pathogenesis of atrial fibrillation (AF) is unclear. Therefore, this study aimed to find the potential competing endogenous RNAs (ceRNAs) network and molecular dysregulation mechanism associated with AF. GSE135445, GSE2240, and GSE68475 were obtained from the Gene Expression Omnibus (GEO). Differential analysis was utilized to identify the differentially expressed mRNAs, miRNAs, and lncRNAs between AF and sinus rhythms (SR). AF-associated mRNAs and nanomaterials were screened and their biological functions and KEGG signaling pathways were identified. Nanomaterials for targeted delivery are uniquely capable of localizing the delivery of therapeutics and diagnostics to diseased tissues. The target mRNAs and target lncRNAs of differentially expressed miRNAs were identified using TargetScan and LncBase databases. Finally, we constructed the ceRNAs network and its potential molecular regulatory mechanism. We obtained 643 AF-associated mRNAs. They were significantly involved in focal adhesion and the PI3K-Akt signaling pathway. Among the 16 differentially expressed miRNAs identified, 31 differentially expressed target mRNAs, as well as 5 differentially expressed target lncRNAs were identified. Among them, we obtained 2 ceRNAs networks (hsa-miR-125a-5p and hsa-let-7a-3p). The aberrant expression of network target genes in AF mainly activated the HIF-1 signaling pathway. We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF. Our findings have a positive influence on investigating the pathogenesis of AF and identifying potential therapeutic targets.
      PubDate: Thu, 29 Sep 2022 12:20:01 +000
  • Sanzi Yangqin Decoction Alleviates Allergic Asthma by Modulating Th1/Th2
           Balance: Coupling Network Pharmacology with Biochemical Pharmacology

    • Abstract: This study aimed to verify that Sanzi Yangqin Decoction (SYD) can relieve asthma in mice and explore the effect on TH1/Th2 balance. The targets of SYD and asthma were explored from the public database using various methods. The potential targets and signaling pathways were identified by KEGG enrichment analysis from DAVID database. Mice asthma models were established using OVA and aluminum hydroxide. Lung tissues of mice were stained with HE and Masson. The contents of IFN-γ, IL-4, and TNF-α in BALF and IgE in mouse serum were detected using ELISA. In addition, the changes in Th1 and Th2 cells of the spleen were detected by flow cytometry. Fourteen core targets including IL4, IFNG, and MMP9 were identified for the treatment of asthma by SYD. The content of IL-4 in the lung tissue and BALF was gradually decreased with the increase in SYD concentration, while the IFN-γ was gradually increased. The drug significantly reduced IgE levels in serum and TNF-α in BALF. The number of Th1 cells in the spleen increased, while Th2 cells decreased in a concentration-dependent manner. SYD can alleviate pulmonary inflammation, restore Th1/Th2 balance, and relieve asthma.
      PubDate: Thu, 29 Sep 2022 12:20:01 +000
  • Application of Quantitative Assessment Strategy-Based Nursing Combined
           with Empathic Nursing in Patients Undergoing Tension-Free Inguinal

    • Abstract: Objective. This study aimed to explore the application of quantitative assessment strategy-based nursing combined with empathic nursing in patients undergoing tension-free inguinal herniorrhaphy. Methods. 82 patients who underwent tension-free inguinal herniorrhaphy in our hospital from May 2020 to December 2021 were enrolled. According to the random number table method, they were divided into three groups (A, B, and C). Patients in group A received quantitative assessment strategy-based nursing combined with empathic nursing, and group B received quantitative assessment strategy-based nursing. Group C received a routine intervention. The early recovery of the three groups was observed. Heart rate (HR), oxygen saturation (SpO2), and blood pressure (BP) were recorded before entering the operating room and at the beginning of anesthesia. Mental Health Continuum-Short Form (MHC-SF, adult version) was used to assess the psychological status. The Modified Barthel Index (MBI) score of three groups at different time points was recorded. The complications of the three groups were observed. Results. Compared with group C, wound healing time, ambulation time, hospital stay time, and time to resume daily activities in groups A and B were significantly shorter (all ). At the beginning of anesthesia, HR and BP levels in the three groups were all decreased, with HR and BP levels in group A lower than those in group C and HR levels in group B lower than those in group C (all ). After the intervention, the scores of emotional well-being, psychological well-being, and social well-being in groups A and B were higher than those in group C and the scores of psychological well-being and social well-being in group A were higher than those in group B (all ). The daily living ability score of group A was higher than that of groups B and group C at discharge, one month after discharge, and three months after discharge, and the daily living ability score of group B was higher than that of group C at these three time points (all ). No significant differences were observed in the incidence of complication rate among the three groups (10.71%, 14.81%, and 29.63%) (χ2 = 3.616, all ).Conclusion. Quantitative evaluation strategy-based nursing combined with empathic nursing can effectively improve the early recovery of patients undergoing tension-free inguinal herniorrhaphy, reduce their stress response, and improve their mental health and daily living ability.
      PubDate: Thu, 29 Sep 2022 12:20:01 +000
  • Effect of Vacuum Sealing Drainage on Soft Tissue Injury of Traumatic
           Fracture and Its Effect on Wound Recovery

    • Abstract: Purpose. The current work is mainly to explore the effect of vacuum sealing drainage (VSD) on soft tissue injury (STI) caused by traumatic fractures (TFs) and its effect on wound recovery. Methods. We first selected 90 patients with TF STI from May 2019 to May 2021, of which 40 patients (control group) received routine treatment, and the other 50 patients (observation group) were treated with VSD. The curative effect, rehabilitation (changing dressing frequency, healing time, and hospitalization time), pain severity, patient comfort, and complications were evaluated and compared. Results. The observation group exhibited a higher total effective rate, lower dressing change frequency, complication rate, and shorter healing time and hospital stay than the control group, which are statistically significant. Statistically milder pain sensation and better patient comfort were also determined in the observation group. Conclusions. VSD is effective and safe in the treatment of TF-induced sexually transmitted infections, which can effectively accelerate wound recovery while reducing pain sensation and improving patient comfort, with clinical promotion value.
      PubDate: Thu, 29 Sep 2022 12:20:01 +000
  • Therapeutic Investigation of Standardized Aqueous Methanolic Extract of
           Bitter Melon (Momordica charantia L.) for Its Potential against Polycystic
           Ovarian Syndrome in Experimental Animals’ Model: In Vitro and In Vivo

    • Abstract: Polycystic ovarian syndrome (PCOS) is an heterogenous, endocrine, metabolic, and multidisciplinary disorder of reproductive-aged females that aggravates insulin resistance, hyperandrogenism, obesity, menstrual irregularities, and infertility. Bitter melon is consumed as vegetable in various parts of the world. The purpose of this study was to provide the rationale for the folkloric uses of bitter melon (Momordica charantia L.) in reproductive abnormalities. HPLC analysis of standardized aqueous methanolic extract of bitter melon revealed the presence of various phytochemicals such as quercetin, gallic acid, benzoic acid, chlorogenic acid, syringic acid, p-coumaric acid, ferulic acid, and cinnamic acid. Twenty-five Swiss albino adult female rats (120–130 g) were acquired and divided into two groups (5 + 20). Letrozole (1 mg/kg p.o.) was used for four weeks to induce PCOS in twenty rats. Disease induction was confirmed by vaginal smear cytology analysis under the microscope. Animals were further divided into four groups, with one group as PCOS group, and the remaining three are treated with standardized extract of bitter melon (500 mg/kg p.o.), bitter melon plus metformin (500 mg/kg p.o.), and metformin alone for the period of next four weeks. After four weeks, the rats were euthanized at diestrus stage. Ovaries of the experimental animals were removed and fixed in 10% buffered formalin, and blood samples were obtained from direct cardiac puncture and stored. Ovaries histopathological analysis showed cystic follicles (9–10) in PCOS group, while, in all the treatment groups, we found developing and mature follicles. Similarly, hormone analysis showed significant () reduction of LH surge, insulin, and testosterone levels and improvement in FSH levels. Lipid profile and antioxidant enzymes status were also significantly () improved. In conclusion, the study validates the bitter melon potential as an insulin sensitizer and ovulation enhancer and authenticates its potential in PCOS management.
      PubDate: Thu, 29 Sep 2022 12:20:00 +000
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