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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
Showing 1 - 15 of 15 Journals sorted by number of followers
Journal of Palliative Medicine     Hybrid Journal   (Followers: 52)
Cognitive Neuroscience     Hybrid Journal   (Followers: 31)
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 22)
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 18)
BMC Complementary Medicine and Therapies     Open Access   (Followers: 17)
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 16)
Acupuncture in Medicine     Hybrid Journal   (Followers: 16)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 16)
International Journal of Yoga     Open Access   (Followers: 15)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 14)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 11)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 10)
Alternative & Integrative Medicine     Open Access   (Followers: 10)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 9)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 7)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 6)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Alternative Medicine Studies     Open Access   (Followers: 6)
Journal of Research in Ayurvedic Sciences     Open Access   (Followers: 5)
Medical Acupuncture     Hybrid Journal   (Followers: 5)
Synfacts     Hybrid Journal   (Followers: 5)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Fitoterapia     Hybrid Journal   (Followers: 5)
Asian Journal of Plant Pathology     Open Access   (Followers: 5)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Journal of Ayurveda Case Reports     Open Access   (Followers: 4)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 4)
Indian Journal of Ayurveda and lntegrative Medicine Klue     Open Access   (Followers: 4)
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Journal of Ayurveda     Open Access   (Followers: 4)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 3)
Journal of Natural Remedies     Open Access   (Followers: 3)
Integrative Medicine Research     Open Access   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 3)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 3)
Ancient Science of Life     Open Access   (Followers: 3)
Chinese Medicine     Open Access   (Followers: 3)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 2)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 2)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 2)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Yoga Mimamsa     Open Access   (Followers: 2)
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 2)
Alternative Medicine     Full-text available via subscription   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Muller Journal of Medical Sciences and Research     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
Journal of Ginseng Research     Open Access   (Followers: 1)
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 1)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 1)
Anales de Hidrología Médica     Open Access   (Followers: 1)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Médecine Palliative     Full-text available via subscription   (Followers: 1)
Journal of Fasting and Health     Open Access   (Followers: 1)
Chinese Medicine and Culture     Open Access   (Followers: 1)
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Integrative Medicine & Therapy     Open Access  
Journal of Complementary and Alternative Medical Research     Open Access  
Journal of Health Sciences Scholarship     Open Access  
World Journal of Traditional Chinese Medicine     Open Access  
Natural Volatiles & Essential Oils     Open Access  
Natural solutions     Full-text available via subscription  
Traditional Medicine Journal     Open Access  
World Journal of Acupuncture - Moxibustion     Full-text available via subscription  
Indian Journal of Research in Homoeopathy     Open Access  
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Journal of Traditional Chinese Medical Sciences     Open Access  
Experimental and Therapeutic Medicine     Full-text available via subscription  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
Traditional & Kampo Medicine     Full-text available via subscription  
Research Journal of Pharmacognosy     Open Access  
Intas Polivet     Full-text available via subscription  
Global Journal of Traditional Medicine     Open Access  
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access  
Ipnosi     Full-text available via subscription  
OA Alternative Medicine     Open Access  
Herba Polonica     Open Access  
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription  
International Journal of High Dilution Research     Open Access  
Revista Internacional de Acupuntura     Full-text available via subscription  

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Journal of Health Science and Alternative Medicine
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2673-0294
Published by Mae Fah Luang University Homepage  [1 journal]
  • C15. Content Validity of Thai Version Screening Tool for Cervical Spine

    • Authors: Chanyawat Rueangsri, Rungthip Puntumetaku, Surachai Sae-jun, Supaporn Phadungkit, Torkamol Hunsawong, Thiwaphon Chatprem
      Abstract: Introduction: Cervical spine instability is a disorder in which the cervical spine cannot maintain its normal alignment under physiological loads to protect the blood vessels, nerves, and spinal cord from damage or irritation. The symptoms of cervical spine instability present include neck pain, dizziness, inability to prolong holding the head, and impaired movement. The more severe symptoms can cause cervical spondylolisthesis. Therefore, it is necessary to have an early screening tool for cervical spine instability to avoid complications and consequences. However, this screening tool is limited in its use by language for the Thai therapist who is a non-English speaker. Objective: The primary objective of this study was to translate the 16 items of the cervical spine instability screening tool from English to the Thai language. The secondary objective was to test the content validity of the cervical spine instability screening tool Thai version.  Methods: The cervical spine instability screening tool was translated from the original English language into the Thai language by the process of cross-cultural adaptation. Then, the content validity was tested by using the index of Item-Objective Congruence (IOC) which was obtained by a group of expert. 5 independent experts with clinical experience more than 5 years in treating neck pain patients including 3 physiotherapists and 2 orthopedic surgeons. Results: The IOC index rating by 5 independent experts reached an average of 0.90 (range 0.60-1.00). Conclusion: The screening tool (Thai version) for patients with cervical instability has satisfactory content validity (average IOC = 0.90) for application in clinical practice. 
      PubDate: 2022-07-22
  • A13. Prevalence and Associated Factors of Forward Head Posture among
           Physical Therapy Students

    • Authors: Petcharat Keawduangdee, Tidarat Chotirat, Pattharaporn Suwandee, Panuwit Paemard
      Abstract: Introduction: The students in the physical therapy program, however, have the activity during study hour, but they have to spend many hours studying in front of the computer which leads to the forward head posture.  Objective: The aim of this study is to investigate the prevalence and related factors of the forward head posture. Methods: This cross-sectional study was conducted in 98 physical therapy students. The participants were asked about personal data, the last day and last week screen time duration which were collected by phone, and the physical activity by Thai Global Physical Activity Questionnaire version 2 (GPAQ). After that they measured the Tragus wall distance (TWD) to diagnose the forward head posture.  Results: The results show that the prevalence of forward head posture is 65.31 and the factors associated with forward head posture were screen time (p-value < 0.01) and physical activity (p-value <0.05).  Conclusion: There was a high prevalence of forward head posture in physical therapy students in Mae Fah Luang University which were associated with high screen time and low physical activity.
      PubDate: 2022-07-21
  • A15. The Effect of Combined the Pursed Lips and Lower Costal Breathing
           Exercise and Chest Mobilization Program on Lung Volume for Acute
           Exacerbations of Chronic Obstructive Pulmonary Disease

    • Authors: Sujittra Kluayhomthong, Watjanarat Panwong, Vitsarut Buttagat, Mongkolert Inkamdang, Prarit Preechamat
      Abstract: Introduction: Changes of the structure of the lungs and bronchi in patients with chronic obstructive pulmonary disease and acute exacerbations lead to increased airway resistance and expiratory flow limitation (EFL). This results in increase end expiratory lung volume (EELV) or air trapping in the alveoli. The patient has more symptoms including shortness of breath, cough, and sputum production.
      Objective: The aim of this study was to investigate the pursed lips and lower costal breathing exercise and chest mobilization on lung volume and dyspnea in patients with chronic obstructive pulmonary disease after acute exacerbations (AECOPD) and hospitalization.
      Methods: Ten patients (7 males; mean age 72 years) diagnosed with AECOPD, who had stable of vital sign (such as SBP between 30-140 mm Hg, DBP between 60-90 mm Hg, SpO2 > 90%), good cooperation and communication, received the pursed lips and lower costal breathing exercise and stretch anterior chest wall program. Each exercise was performed 10 times/set, 3 sets/day for 2 day consecutively. The slow vital capacity (SVC) and dyspnea were measured before and after treatment period.
      Results: The result indicated that the usual care program showed significant improvement in SVC after 2 days of treatment (p=0.03). However, the rating perceived exertion (RPE), heart rate (HR) and pulse oxygen saturation (SpO2) showed no significant change (p=0.591, p=0.604 and 0.193 respectively).
      Conclusion: The results suggest that the pursed lips and lower costal breathing exercise and stretch anterior chest wall program were effective for increasing the SVC and safe among the chronic obstructive pulmonary disease with acute exacerbations during hospitalization.
      PubDate: 2022-07-21
  • A21. The Immediate Effects of Star Excursion Balance Training on Balance
           and Walking Ability in Healthy Elderly People: A Randomized Controlled

    • Authors: Janya Chuadthong, Nattida Chaisiri, Onruhdee Nusomkaew, Supakchaya Ketangkool, Ploypailin Namkorn, Chatchada Sutalanga
      Abstract: Introduction: Aging is defined as a natural process characterized by structural and functional changes. Functional impairments are linked to changes in balance and walking ability with aging. These impairments are the most common cause of falls among the elderly, which also reduce their quality of life. Therefore, balance training is essential for fall prevention in elderly people.  Objective: To study the immediate effect of star excursion balance training on balance and walking speed in healthy elderly people.  Methods: Thirty-eight participants were aged 60 to 69 years old, both males and females. All participants were randomized into 2 groups including the experiment group that received star excursion balance training (n=19) and the control group that received stretching exercise (n=19). Both groups received 10 minutes of warm-up and cool-down and 30 minutes of exercise per session for 1 session. Static balance control was assessed by measuring the single-leg stance (SLS) test, dynamic balance control was assessed by measuring the time up and go (TUG) test, and walking speed was assessed by measuring the 10-meter walk test (10MWT), respectively. All outcome measurements were tested before and after receiving the intervention.  Results: The results revealed that there were no significant differences in all outcome measurements between groups (p>0.05). In comparison within groups, there were no significant differences in the SLS test in both groups (p>0.05). However, there were significant differences in the TUG test and 10MWT after receiving intervention within the experimental group (p<0.05).  Conclusion: The immediate effects of star excursion balance training resulted in improved dynamic balance and walking speed. The results of this study will provide useful clinical information for future rehabilitation programs for the elderly. However, this study focused on the immediate effect of star excursion balance training.  This may not cover the long-term effects of exercise on balance in the elderly.
      PubDate: 2022-07-21
  • A23. Comparison Physiological Effect and Comfortable Sensation between
           Wearing Surgical Face Mask and Muslin Face Mask during Exercise in Healthy
           Subject: A Pilot Study

    • Authors: Watjanarat Panwong, Kunnatee Keawthawada, Jentera Kongrit, Nichakorn Pichainsathain, Sujittra Kluayhomthong, Sitang Kongkratoke
      Abstract: Introduction: Widely spread of COVID-19 virus worldwide leads to changes in daily living situations such as; keeping social distance, frequently cleaning hands, and wearing a face mask all the time even while exercising to against the spread of the virus. Objective: This study aims to compare the effect of wearing 3 types of face masks; Non face masks (NFM), Surgical face masks (SFM), and Muslin Face masks (MSM); while exercising with moderate intensity to cardiovascular response and comfortable feeling while wearing face mask in healthy adult participants. Methods: Cross-over design was used to investigate the study’s objective. Ten healthy participants aged 20.9±1.5 years old, BMI of 21.26±1.33 kg/m2 performed treadmill exercise while wearing NFM, SFM, and MFM with an intensity of 40-59% Heart rate reserve (HRR) for 30 minutes. Perceived Comfort Scale (PCS) and Cardiovascular response including; Blood pressure (BP), Respiratory rate (RR), Oxygen Saturation (O2sat), Rating Perceived Breathlessness (RPB), and Borg Rating of Perceived Exertion (RPE) were recorded in each exercise session with a wash-out period for 48 hours. Results: All participants can complete the exercise with moderate intensity while wearing 3 types of face masks. After 3 sessions of exercise, systolic BP and PCS showed a significant difference between types of face masks (p-value = 0.024, 0.033, respectively). Change SBP between baseline to exercise have significant difference when compare NFM vs SFM (p-value = 0.042) and NFM vs MFM (p-value = 0.035); Change SBP value equal 9.3±11.52 mmHg in NFM, 18.8±7.38 mmHg in SFM, and 18.9±6.87 mmHg in MFM. PCS scores have a significant difference in NFM vs MFM; score 25.9±2.02 and 28.5±3.41, respectively (p-value = 0.018). Diastolic BP, RR, O2sat, RPB, and RPE were not found significantly different between groups. Conclusion: Wearing SFM and MFM while exercising with moderate intensity leads to increased SBP and discomfort feeling more than NFM. However, it seems to be that wearing SFM and MFM does not affect exercise performance and dangerous responses for healthy adults. According to this pilot study, further studies with a larger sample should confirm these initial results.
      PubDate: 2022-07-21
  • C02. The History and Development of TCM Ointment Therapy

    • Authors: Nakornsub Lawcharoen, Piyapach Thongprew, Raksuda Taniguchi , Sitthichock Vadphimai, Wachiraporn Padungkiettiwong, Pitchayut Chambumrung
      Abstract: Ointment massage (paste massage) is a traditional external treatment method of traditional Chinese medicine. It is a form of massage and ointment used together by using the ointment as the medium, applying paste before manipulation, and then applying the Tuina massage technique. The ointment has been used for over 2000 years, as early as the pre-Qin period. With the development of history, from the northern and Southern Dynasties, Sui and Tang Dynasties, Song, Jin, Yuan Dynasties, and Ming and Qing Dynasties. Up to now, ointment massage therapy can treat various clinical diseases and has a significant curative effect, which more and more patients have recognized. This paper showed the development of ointment in Traditional Chinese Medicine history to the modern period. 
      PubDate: 2022-07-21
  • C04. Case Report: Treating Atopic Dermatitis with Si-Wu-Xiao-Feng
           Decoction in combination with Topical Huang Qin Cream

    • Authors: Sinee Tantasatityanon, Chakree Wattanasiri, Wang Xu
      Abstract: The aim of this study is to evaluate the efficacy of treating Atopic Dermatitis with the Traditional Chinese Medicine (TCM) Formula of Si-Wu-Xiao-Feng decoction in combination with Topical Huang Qin Cream. The case report is from a 42 years old female patient presented with lesions of small blisters bilaterally spread all over her arms and legs. The blisters often become very itchy and has affected the patient for over 5 years. The blisters became more severe during the past 2 months. She is prescribed Si-Wu-Xiao-Feng decoction to drink daily 30 minutes after breakfast and dinner. The TCM herb composition of the Si-Wu-Xiao-Feng Decoction is adjusted after each follow up according to the severity and condition of the blisters. She is also prescribed a Topical Huang Qin Cream. This is an extemporaneous formulation prepared by the Institute of Thai-Chinese Medicine Mae Fah Luang University. After 6 months of treatment, the lesions of blisters, papules and scaly skin has recovered back to normal skin. After treatment was discontinued, the patient was followed up at 2 weeks and shown no eruption of blisters or signs of itchiness. Moreover, the patient liver and kidney function were measured at the 3rd month during the treatment. All parameters were within normal range. In conclusion, treating Atopic Dermatitis with the combination of Si-Wu-Xiao-Feng decoction and Topical Huang Qin Cream has shown good efficacy. It also shown potential in preventing the recurrence of the disease and is safe for the patient. This treatment regimen should be studied in a wider clinical setting for developing new treatments for Atopic Dermatitis patients in the future.
      PubDate: 2022-07-21
  • C05. The Effectiveness of Thai Traditional Massage in Improving
           Constipation at Institute of Thai-Chinese Traditional Medicine Hospital,
           Mae Fah Luang University

    • Authors: Panitha Boonma, Yanisara Saythanant, Anguara Charkreyavanich, Krittapat Phairoh, Panada Ramphaiboon
      Abstract: Thailand, and if left for a long time. This can lead to many complications and affect daily life. Today, the treatment for constipation most of them uses laxatives. Long-term use of laxatives can cause drug resistance. Therefore, the purpose of this study is to study the effectiveness of Thai traditional massage in improving constipation and the study satisfaction with the treatment of chronic constipation. Methodology: This study was a one group study design, clinical trial in patients with chronic constipation. The research participants were female or male, aged 20 - 45 years, residing in Chiang Rai province. Thirty subjects had constipation according to Rome III criteria and were diagnosed with constipation that wasn't caused by mechanical obstruction or due to another cause such as cancer by a modern physician. All will be treated with Thai traditional massage and herbal compresses to treat chronic constipation for a period of 1 day and collected data with measuring instruments, including a recorded form. Results: The study showed improved behavior of defecation, urination, and decreased use of laxatives. There was an increase in the number of times defecation. Difficulty in defecation, inability to defecate, abdominal pain during defecation, time to use defecate, and use of laxatives or manual maneuvers to facilitate defecations are decreased. In addition, the satisfaction of the research participants in terms of quality of service, quality of treatment, and overall satisfaction level were strongly satisfied. Conclusion: The study had shown that Thai traditional massage for chronic constipation helps to stimulate the frequency of bowel movements without any side effects. It was concluded that the Thai traditional massage was safe and suitable to be used to treat primary constipation.
      PubDate: 2022-07-21
  • C06. The Effect of Court-Type Thai Traditional Massage on Delayed-Onset
           Muscle Soreness in The Biceps Brachii Muscle After Resistance Exercise

    • Authors: Vassana Charoonsrisawad, Kulthida Lianglai, Meena Seepaeng, Suhada Baoa, Sirikool Klumkool, Tanyarath Tapcompill
      Abstract: Introduction: Delayed onset muscle soreness (DOMS) when they perform a different type of sport or practice new skills. DOMS is different from the acute pain experienced during and shortly after exercise. It usually appears after a pain free period (12–24 h), peaks at 24–72 hours and disappears within 7 days of the exercise.  Objective: To investigate the Effect of Court-Type Thai Traditional Massage (CTTM) on DOMS in The Biceps Brachii Muscle After Resistance Exercise. Methods: Mae Fah Luang University student female, aged 18-22 years, 30 people. This was a Randomized Control Trial study. The volunteers were divided into 2 groups, the first group was a Court type Thai massage experiment with 15 people and the second group was a control group of 15 people. The subjects tested the Visual Analogue Scale (VAS), Range of Motion (ROM) and swelling were measured before, immediately and 24, 48 and 72 hours after the exercise.  Results: The results showed by comparing the differences between the groups, it was found that there was a statistically significant decrease in pain level (p<0.05) at 48 hours. Range of motion of the experimental group there was statistically increased (p<0.05) at 72 hours. The swelling of the muscles was not statistically in both groups and between groups.  Conclusion: CTTM can help muscles relax, reduce muscle contraction and reduce DOMS symptoms after resistance exercise. which shows that the CTTM after the experiment in the experimental group, VAS was lower than the control group and increased range of motion.
      PubDate: 2022-07-21
  • C07. Effect of Aromatic Medicine (YA HOM TEP PRA CHIT) on Patients with

    • Authors: Tanyarath Tapcompill, Sirikool Klumkool, Vassana Charoonsrisawad
      Abstract: Introduction: Aromatic medicine, using herbal remedies to help decrease blood pressure. There is a formulation that helps to treat lower blood pressure. It has properties to decrease blood pressure levels and nourish the heart called “YA HOM TEP PRA CHIT.”  Objective: The main objective of this study is to determine if the addition of aromatic medicine can decrease blood pressure with standard treatment for a patient with hypertension compares patient with standard treatment.  Methods: Study on the patient with hypertension in Wiang Chiang Rung Hospital. After purposive sampling, 80 patients were divided into 2 groups. The 40 people in the intervention group were treated by Select subjects based on screening with inclusion and exclusion criteria and were randomized into 2 groups such as the experimental group of patients taking Enalapril 5-15 mg /day) with Taking a dose of YA HOM TEP PRA CHIT 3 capsules 3 times before meal (1,200 mg/day) once a day in the morning by the standards and evaluation satisfaction after the treatment  Results: The results of the study concluded that the average blood pressure at pretest and post-test in the experimental group had an average decrease. Baseline characteristics between the treatment and control groups were similar. Before the treatment, the systolic blood pressure of the intervention and control group in term of after the treatment showed the average of systolic blood pressure of the control group before joining the study and before the treatment are 153.13,153.83,153.93,154.98, and 154.98. The average of diastolic blood pressure of the intervention group before joining the study and before the treatment showed the average of diastolic blood pressure of the control group before joining the study and before the treatment are 84.38,85.05,85.53,86.15, and 86.40.  Conclusion: For the comparison of average systolic blood pressure after the treatment of both groups are statistically significant differences at the 0.05 level, but before the experiment, the average systolic blood pressure of both groups does not have statistically significant differences at the 0.05 level. And for the comparison of average diastolic blood pressure after the treatment in week2-4 of both groups are statistically significant differences at the 0.05 level.
      PubDate: 2022-07-21
  • C11. Effect of a pain management Combined with Mahajak oil medicine
           program in elderly with osteoarthritis: A Case study of Thay Nam Health
           Promoting Hospital, Pho Thale District, Phichit Province

    • Authors: Thanach Kanokthet, Theerawit Klaharn
      Abstract: Introduction: Osteoarthritis (OA) is a chronic, degenerative, musculoskeletal disease with global prevalence of 20% of women and 10% of men over 60 years of age. Most patients with OA of the knee will develop progressive functional limitation and physical disability with age. The prevalence of symptomatic OA of the knee among elderly Thai   people was reported as 10.40% (women) and 4.20% (men). The disabling symptoms of knee OA in older patients, such as chronic pain and joint stiffness potential to cause psychological changes in patients, leading to the quality of life of older Objective: were to study results of pain management Combined with Mahajak oil medicine program and compare knowledge, attitude, Levels of knee pain and Degree of passive knee flexion on Elderly   Methods: quasi-experimental research with three-groups and repeated-measures design. The sample group was selected with purposive sampling. The 90 cases of elderly were patients with the severity of the disease osteoarthritis Mild to Severe (39-20 points). They were separated into three groups into 3 groups, each group of 30 cases. The experimental group received pain management program Combined with Mahajak oil medicine. The control group received the program together with warm water and the control group without any treatment. One-way repeated measures ANOVA was employed for comparing knowledge scores, attitudes, Levels of knee pain and Degree of passive knee flexion among the experimental group and two control groups. Results: The findings indicated that the experimental group with Mahajak oil medicine usage has average score of knowledge, attitude, and Levels of knee pain higher than pretest and attitude and Levels of knee pain higher than the results of control groups with statistical significance (p-value<0.05). Besides, the results of experimental group with Mahajak oil medicine usage proved that the   average range of Degree of passive knee flexion were better than before the program after the fourth week and twelfth week. The results of the fourth week and twelfth week were statistically significant difference with the first week (p-value<0.05). For pair comparison, it was found that there were two different pairs: the group with Mahajak oil medicine usage and the control group. Meanwhile, no statistically significant difference was found between the group with warm water and the control group (p-value<0.05). Conclusion: pain management program Combined with Mahajak oil to provide effective health services
      PubDate: 2022-07-21
  • C20. The Effectiveness of 5% White Tea (Camellia sinensis) Cream for
           Periorbital Wrinkle Reduction

    • Authors: Khin Thapyay Phyu, Tanomkit Pawcsuntorn
      Abstract: Introduction: Although we cannot stop wrinkles formation, we can prevent and delay the process of formation. Wrinkle is the skin topographic changes due to aging which is the distinctive sign. Therefore, the researcher studied the effectives of white tea extract cream for periorbital wrinkle reduction. White tea extract contains a higher level of polyphenol which means higher anti-oxidant and anti-aging properties. The white tea extract is rich in polyphenols such as polycatechin, gallocatechin, epicatechin, epigallocatechin gallate (EGCG), epigallocatechin (EGC), gallocatechingallate (GCG), epicatechin gallate (ECG), and flavanols, caffeine and gallic acid. It functions as an anti-oxidant by quenching the free radical and protects oxidative stress damage to the cells. It also inhibits elastase and collagenase activity and maintains elastin, collagen and delays skin aging process. So, it can treat fine lines, wrinkles and maintain elasticity of the skin. Besides, it prevents the occurrence of skin cancer, wrinkling and mottled pigmentation induced by photo damage.  Objective: To study the effectiveness of 5% white tea (Camellia sinensis) extract cream in periorbital wrinkle reduction Methods: This research was a clinical controlled quasi-experimental study with 20 volunteers. The duration of the study was 12 weeks. Parameters such as wrinkle score by VISIA, Rao Goldman 5-point visual scale, cutometer score were used for assessment at baseline visit, 4th, 8th and 12th week. Results: Mean cutometer scores at crow’s feet and under eye area were significantly increased (p value<0.001). Wrinkle evaluation score by VISIA was also statistically increased (p value<0.001). No adverse effect was observed throughout the study. Conclusion: The outcome of this study suggested that 5% white tea (Camellia sinensis) extract cream is effective for periorbital wrinkles reduction and safe for topical application. Hence, it could be an alternative anti-aging treatment for wrinkles reduction.  
      PubDate: 2022-07-21
  • C22. Prevalence and Unit Cost of Abnormalities Detected in Abdominal
           Sonography among Soldiers

    • Authors: Napongpakorn Chumsri, Surachate Siripongsakun, Pooripat Waongenngam, Songpon Srisittimongkon, Chanisa Chotipanich
      Abstract: Introduction:  According to military doctrine, soldiers must maintain their health in order to remain strong and healthy at all times. Furthermore, they must be physically fitter than those in other professions. Objective: To determine the prevalence of detected abnormalities and the unit cost of clinically significant abnormalities discovered during health screening by abdominal ultrasound (US) in soldiers.study the prevalence of detected abnormalities and the unit cost of clinically significant abnormalities from health screening by abdominal ultrasound (US) among soldiers. Methods: This was a retrospective study of 841 male and female soldiers who underwent abdominal US health screening at Chulabhorn hospital between February and September 2020. Data collection included abnormalities detected by ultrasound and diagnostic results classified by clinical significance into three categories: abnormality with no clinical significance, abnormality requiring follow-up, and abnormality requiring treatment. The unit cost for those abnormalities is calculated using the list of diagnostic procedures. The most common abnormalities in the United States are fatty liver, liver nodules, gallbladder polyps, renal stones, solid and cystic renal lesions, and prostate gland enlargement. Results: There were 841 soldiers, 502 males and 339 females, with an average age of 51.8 years. There were 1,043 lesions detected in 643 (76.4 percent) soldiers. Fatty liver affects 364 (43.3 percent) of patients, liver nodules affect 46 (5.5 percent), gallbladder polyps affect 90 (10.7 percent), renal stones affect 41 (4.9 percent), solid and cystic renal lesions affect 128 (15.2%), and prostate gland enlargement affects 113 (22.5 percent). There were 79 abnormalities that were classified as requiring treatment.  The unit cost was 19,007 Baht. Conclusion: The prevalence of abnormalities detected by abdominal US in this study is comparable to that reported in the literature for the general population. As a result, the expectation that soldiers will have fewer abnormalities detected on US soil may not be realized.
      PubDate: 2022-07-21
  • C30. Research Progress on Osteogenic Differentiation of Bone Marrow
           Mesenchymal Stem Cells induced by Traditional Chinese Medicine Monomer

    • Authors: Mengxing Yin , Dezhi Zhou, Xiufang Li , Xiaosan Su , Watchala Thanusin, Fu Jia
      Abstract: As the population ages, osteoporosis has become a global bone disease, increasing the risk of fractures and seriously affecting human health. Bone marrow mesenchymal stem cells (BMSCs) have the potential to differentiate in different directions. Inducing osteogenesis and inhibiting adipogenic differentiation are key to preventing and treating osteoporosis. Traditional Chinese medicine (TCM) is a bone metabolic disease with obvious therapeutic effects. Research results show that the part between traditional Chinese medicine and its purification material can effectively induce bone marrow mesenchymal stem cells to osteoblast differentiation. Focusing on the physiological characteristics of BMSCs, this paper summarized the mechanism of TCM monomers in osteogenic differentiation.
      PubDate: 2022-07-21
  • A01. Clinical Research on the Treatment of Hyperthyroidism with Chaihu
           Guizhi Longu Muli Decoction

    • Authors: Raksuda Taniguchi, Chin Jia Wei, Nakornsub Lawcharoen, Pawat Thanavachirasin
      Pages: 34 - 34
      Abstract: Introduction: The basic formula of Chaihu Guizhi Longgu Muli Decoction (CGLMD) is derived from Xiao Chaihu Decoction combined with Guizhi and Longgu Muli Decoction. At present, many studies in China have proved that the use of CGLMD combined with Western medicine in the treatment of hyperthyroidism is more effective and can reduce the side effects of Western medicine. Objective: To observe the clinical effects of CGLMD combined with antithyroid drugs (Methimazole) in the treatment of hyperthyroidism and safety of CGLMD. Methods: 62 patients were included in the OPD of Endocrinology, First Affiliated Hospital of Guangzhou University of Chinese Medicine from April 2019 to December 2019. Patients are randomly divided into control and treatment groups. Patients in the control group were treated with Methimazole, and the patients in the treatment group were treated with CGLMD combined with Methimazole. The duration of treatment was 4 weeks and 8 weeks for continuous observation. Thyroid function (TSH, FT3, FT4), liver function (AST, ALT) and blood analysis (WBC, NEU), self-designed clinical symptom observation scale, and clinical symptom registration form were observed before and after treatment. Results:
      1. Total score of TCM in treatment group decreased more than control group (P<0.05). In 29 symptoms that were observed, the treatment group improved 21 symptoms, including mental depression, palpitation, thirst, etc. (P<0.05). The control group effectively improved depression and insomnia (P<0.05). The total effective rate of the two groups was 78.2% and 26.7% respectively, and the difference was statistically significant (P<0.05).
      Thyroid function of patients in both groups was reduced (P<0.05), and the TSH between 2 groups not statistically different (P>0.05), while FT3 and FT4 were statistically difference (P<0.05).
      3 cases of abnormal liver function were found in the control group, with no other adverse reactions. There was no obvious abnormality in blood analysis between two groups. Conclusion: The results proved that the combination of CGLMD with antithyroid drugs can obviously alleviate the clinical symptoms of patients although the effective improvement of TSH level was not obvious, and the treatment was safe for patients. Keywords:  Guizhi Longgu Muli Decoction; hyperthyroidism; clinical efficacy
      PubDate: 2022-07-19
  • A02. Impact of Scoliosis on Gait Characteristics: A Case Study of A Child
           with Spastic Diplegic Cerebral Palsy

    • Authors: Ampha Pumpho, Phathakoj Thoopthong, Patatavijitra Kok-kaew, Prim Hirunyakarn, Supapon Kaewsanmung, Patcharawan Suwannarat
      Pages: 35 - 35
      Abstract: Introduction: Neuromuscular scoliosis is a common musculoskeletal problem for people with cerebral palsy. Neuromuscular scoliosis develops due to poor muscle control and spasticity. Scoliosis is not only a spinal deformity, but also possibly leads to the development of gait pathology and impact on postural control and the quality of life.  Objective: To verify the impact of scoliosis on gait characteristics of a child with spastic cerebral palsy. Methods: To comply with the proposed objectives, three children with spastic diplegic cerebral palsy, GMFCS level III, participated in this study. One case was a 12-years old with scoliosis, and another two cases were boys without scoliosis, aged 7 and 8 years. The participants performed a 10-Meter Walk Test. The main outcome variables including gait cycles, gait speed, cadence, and stride length were measured by OPAL accelerometer, which were analyzed using Mann-Whitney U Test.  Results: The results showed no difference in gait speed, cadences, and stride length among the child with spastic diplegic cerebral palsy with and without scoliosis. However, for the gait cycles, the stance phase and double support of the child with scoliosis trended to be longer than those without scoliosis.  Conclusion: Further investigations are certainly need to assess the impact of scoliosis on gait characteristics in children with spastic cerebral palsy. 
      PubDate: 2022-07-21
  • A03. Immediate Effect of Thai Massage on Calf Muscle Flexibility and
           Postural Sway in Overweight Children: Pilot Study

    • Authors: Supapon Kaewsanmung, Patcharawan Suwannarat, Ampha Pumpho, Vitsarut Buttagat, Kanokthip Sawangjaithum
      Pages: 36 - 36
      Abstract: Introduction: Nowadays, overweight children are increasing and possibly impact on postural control. The excessive body weight reacted to postural perturbations and various body systems. Maintaining posture is essential for daily activities. However, the intervention to improve postural balance in overweight children is limited. Objective: To explore the immediate effects of Thai massage on postural balance by recording the trajectory of the center of pressure (COP) in overweight children.
      Methods: Twenty Thai children who are 10 – 12 years old with overweight (BMI from 85th to 94th percentile) were recruited from the school in Chiang Rai province and then categorized into treatment and control groups. Postural sway was examined using a force plate (Zebris Medical, Isny, Germany). Gastrosoleus muscle flexibility was measured by weight bearing ankle lunge test. The treatment group received a Thai massage for 30 minutes on the area of both feet, legs and hips and the control group rested on bed. Results: There were no statistically significant differences between groups of postural sway. The flexibility of gastrosoleus muscle was significantly differences between groups (p<0.05). Conclusion: Thirty minute of Thai massage sessions showed immediate improvement of muscle flexibility that is important for postural control. However, there are some limitations of this study including small sample size and convenience sampling.
      PubDate: 2022-07-21
  • A04. Relationship between Balance Ability and Ankle Function in Patients
           with Diabetes Mellitus and Peripheral Neuropathy

    • Authors: Kitiyawadee Srisim, Sopida Maneemart, Patcharapa Chitrattanawisut
      Pages: 37 - 37
      Abstract: Introduction: Peripheral neuropathy is the main complication resulting in ankle muscle weakness in patients with diabetes mellitus. The dysfunction leads to impair balance control and increase risk of falls in these individuals. Recently, there is limited evidence regarding the correlation between balance ability and ankle function in patients with diabetes mellitus and peripheral neuropathy (DMPN). Objective: A cross-sectional study to investigate the correlation between balance ability and ankle muscle function in patients with DMPN. Methods: 34-DMPN participants were evaluated for balance ability using one-leg stance test (OLST) with eye-open and eye-close conditions. Then, they were assessed ankle muscle strength using a hand-held dynamometer (HHD) in 4 muscle groups. The relationship was investigated using Spearman's Rank Correlation Coefficient. Results: The average age of DMPN participants was 62.64 ± 5.21 years old, and the score of peripheral neuropathy using 5.07 monofilament was 4.11 ± 2.68 points. The findings found a significant correlation between both OLST and the ankle plantar flexor muscle group (0.439, p=0.009 for OLST eye-open, 0.491, p=0.003 for OLST eye-close). In addition, a significant correlation was found in OLST eye-close condition for the ankle invertor muscle group (0.439, p=0.009) and evertor muscle group (0.449, p=0.008).  Conclusion: The findings showed the importance of ankle muscle function to balance control in DMPT. However, further studies should compare the result with a healthy in order to confirm the relationship between peripheral neuropathy and muscle activation in DMPN.
      PubDate: 2022-07-21
  • A05. Surface Anatomical Positioning of the 2nd and 3rd Shoulder Signal
           Points of Court-type Thai Massage in Male Humans

    • Authors: Pornnarez Thaweekhotr
      Pages: 38 - 38
      Abstract: Introduction: The 2nd and 3rd shoulder signal points are on the neck region of the human body which are essential for the examining and massaging of symptoms in Thai traditional medicine. Objective: This research aimed to identify the 2nd and 3rd shoulder signal points on the x and y - coordination of male human body. Methods: The thirty healthy male volunteers (18-22 years, 65-75 kg. weight, 170-179 cm. height and BMI = 18.5-24.9) were included in this research. They were divided into groups A B C and matched with the reference persons A B C consecutively. After the 2nd and 3rd shoulder signal points were identified by the reference persons, the lateral aspect of the mastoid process was tagged as the surface anatomical landmark. Then the photograph was recorded. The 2nd and 3rd shoulder signal points were measured with the ImageJ software. Results: The lateral aspect of mastoid process was the origin of the x and y coordination. The average distance of 2nd shoulder signal point was at x = 0.7±0.6 cm.; y = -8.2±0.9 cm. in group A, x = 0.0±1.2 cm.; y = -8.7±0.9 cm. in group B, and x = 2.6±1.4 cm.; y = -14.5±1.1 cm. in group C. The distance of 3rd shoulder signal point was x = 0.8±0.3 cm.; y = -9.2±1.0 cm. in group A, x = 0.8±0.9 cm.; y = -11.5±1.3 cm. in group B, and x = 2.3±1.4 cm.; y = -15.2±1.1 cm. in group C. The average of intersection of 2nd and 3rd shoulder signal points were at x = 1.1±1.6 cm; y = -10.5±3.0 cm. and x = 1.3±1.2 cm.;
      y = -11.9±2.7 cm. consecutively. Conclusion: The signal points of court-type Thai massage could be manifested into the universal form and the surface anatomical landmark should be considered for identifying accurately.
      PubDate: 2022-07-21
  • A06. Application of Tonifying Kidney, Invigorating Qi, and Promoting Blood
           Circulation in Common Gynecological Diseases

    • Authors: Yufan Song , Lingling Yu , Mingmin Zhang
      Pages: 39 - 39
      Abstract: The concepts and theories of tonifying kidney, invigorating Qi, and activating blood circulation originate from “Nei Jing”, which have become the essence of traditional Chinese medicine theory, providing theoretical support for the establishment of new methods for the treatment of various obstetrics and gynecology diseases, as the disease spectrum has broadened and the understanding of diseases has deepened.  These three treatments can be used separately or in combination. Our research team has flexibly implemented the technique of invigorating the kidney, nourishing qi, and activating blood circulation to clinical therapy. For example, in the case of embryo implantation failure, Bushen Antai recipe, which means tonifying kidney and miscarriage prevention, could be used to promote the endometrial receptivity, angiogenesis, and immunological tolerance at the maternal-fetal interface, thereby resulting in a better pregnancy outcome. As for the premature ovarian failure, Siwu Tang, which can nourish the blood and activate the circulation, has been taken as the basic recipe to promote ovarian angiogenesis and the function of granulosa cells, thus improving the follicular development and restoring the ovarian reserve. Regarding the polycystic ovary syndrome, Jiaotai Siwu decoction, which clears away the heart fire, warms the kidney, and relieve the water retention, is used to coordinate the heart and kidney and alleviate the abnormal metabolism, endocrine, and chronic inflammation state, so as to repair the ovarian ovulation. Over the last 10 years, our study group has been dedicated to the application and mechanism exploration of principles of tonifying kidney, invigorating Qi, and activating blood circulation in regulating menstruation, embryo implantation, and protection of the embryo development, which enrich the scientific connotation of traditional Chinese medicine in treating gynecological diseases.
      PubDate: 2022-07-21
  • A07. Study of Acupuncture Improving Oocytes Quality of Poor Ovarian
           Responders in IVF

    • Authors: Xinyu Zhu
      Pages: 40 - 40
      Abstract: Introduction:   Poor Ovarian Response (POR) occurs among women undergoing In Vitro Fertilization-Embryo Transplantation (IVF-ET), it affects the quantity and quality of retrieved follicles and embryos. Few approaches were proved beneficial for POR patients, while acupuncture might be an effective alternative and complementary therapy.  Objective: This random controlled trial (RCT) was conducted to investigate the effect of acupuncture on oocytes quality of Poor Ovarian Response (POR) patients in IVF. Methods: POR patients were randomly assigned into acupuncture + IVF group and IVF group. The study period was 20 weeks, including baseline for 1 week, acupuncture treatment for 8 weeks, IVF cycle for 3 weeks and an 8-week follow-up. Acupuncture was performed in the acupuncture plus IVF group, from two menstrual cycles before IVF cycle, three times a week, except the menstrual period, until the HCG injection day, besides, IVF group received no acupuncture. Both groups received a micro stimulation program for follicle stimulation in IVF. The main outcomes were mature oocytes rate and high quality embryo rate, secondary outcomes included number of eggs retrieved, number and rate of fertilization, rate of high-quality embryos, number and rate of available embryos, Gn dosage and GN days. Above outcomes were evaluated on the third day after follicles were retrieved. Results: The main outcomes: the number of mature oocytes in the two groups was similar(P > 0.05); the high quality embryo rate of acupuncture plus IVF group was significantly higher than that of IVF group (P < 0.01).  Secondary outcomes: Number of high-quality embryos & rate of available embryos in acupuncture + IVF group were significantly higher than those in IVF group (P < 0.05); the number of retrieved eggs, fertilized embryos, available embryos, the rate of fertilized embryos, the dosage and days of Gn were similar between two groups (P > 0.05). Conclusion:  Acupuncture improved the oocytes quality of POR patients in IVF, mainly manifested as increased number and rate of high quality embryos.
      PubDate: 2022-07-21
  • A08. The Effect of Muscle Fatigue on Activation Patterns of the Biceps
           Femoris and Semitendinosus Muscles in Healthy Soccer Players Aged 19 to 35

    • Authors: Dirk Möller, Tobias Michels, Linus Paelke, Nikolaus Ballenberger
      Pages: 41 - 41
      Abstract: Introduction: Hamstring injuries are among the most common injuries in soccer players. Especially the danger of hamstring injuries increases in the final third of each half, with the biceps femoris muscle being highly susceptible, but currently there is no supporting evidence in soccer players. It is important to investigate to provide a basis for further clinical investigations in order to reduce the risk of hamstring injuries. Objective: To investigate a soccer-specific muscle fatigue protocol has an effect on the activation patterns of the biceps and semitendinosus muscles and correlates with the subjectively perceived exertion of the soccer players. Methods: 19 healthy soccer players aged 19 - 35 years were included and underwent a standardized procedure that included: (1) performance of the nordic hamstring curls (NHC) and a 10m sprint (pre-test), (2) a soccer-specific muscle fatigue loading protocol for 30 minutes with subsequent rating of perceived exertion (RPE), (3) re-assessed like pre-assessment (post- test). Electromyography (EMG) data were recorded the biceps and semitendinosus muscles of both legs. Two parameters were analyzed: the peak amplitude during the NHC and the mean amplitude during the 10m sprint. Results: The RPE score (9.5, p<0.001) and 10m sprint shows significant differences between pre- and post- test for the biceps (standing leg: -82.45, kicking leg: -81.77; p<0.01) and semitendinosus muscle (standing leg: -60.08, p=0.001); kicking leg: -65.30, p=0.03). Significant correlation exists between RPE score and biceps muscles at post-test (standing leg: r=-0.54, kicking leg: r=-0.51; p<0.05). Conclusion: Muscle fatigue leads to significant changes in the activation behavior of the hamstring muscles. In particular, the biceps muscle shows a correlation with perceived exertion, the higher the exertion, the lower the muscle activity. This may help explain the higher prevalence of the biceps muscle in hamstring injuries and offers a basis for further clinical investigations.
      PubDate: 2022-07-21
  • A09. Relationship between Predisposing Factors and Risk of Work-Related
           Musculoskeletal Strain among Poultry Slaughterhouse Workers – A Cross
           Sectional Study

    • Authors: Benjamaporn Hancharoenkul, Peanchai Khamwong, Ubon Pirunsan, Leonard Joseph, Natharin Boontha
      Pages: 42 - 42
      Abstract: Introduction: In Thailand, the poultry slaughterhouse industry is one of the largest sectors of the food industry which continues to grow as well as the number of poultry workers that increase significantly. The poultry workers are exposed to repetitive movements and prolonged standing for entire working hours, which may predispose to the risk of work-related musculoskeletal strain (WMS) especially at the upper limb and neck region. Objective: To evaluate the relationship between predisposing factors and the risk of WMS among poultry slaughterhouse workers. Methods: A cross-sectional observational study was conducted in Thailand among 78 poultry slaughterhouse workers. A self-reported profile of the workers were collected. Rapid Upper Limb Assessment (RULA) was conducted to examine the risk of WMS to upper limb and neck by a physiotherapist. The total RULA score at 7 (high risk level) was used as a cut off point for investigating the relationship between the predisposing factors and WMS risk by using the binary logistic regression analysis (AMSEC-64EX-112).  Results: A total of 78 participants, 48.7% (N=38) men, and 51.3% (N=40) women participated in the study with a mean age of 39.12±9.33 years. The mean work experience and working hours/day were 4.33±4.04 years, and 10.42±1.59 hours, respectively. 37.2% (N=29) were smokers, and 77% (N=60) worked more than 8 hours/day. About 11.5% (N=9) worked in slaughtering task, 41% (N=32) worked in evisceration task, and 47.4% (N=37) worked in cut-up task. 80.7% (N=63) had RULA score at 7. Predisposing factors: working hours (more than 8 hours) (R2=0.137, β=13.33, p=0.001), evisceration (R2=0.145, β=19.33, p=0.001) and cut-up task (R2=0.145, β=10.33, p=0.005), and smoking (R2=0.05, β=0.31, p=0.048) were significantly associated with RULA. Conclusion: This study identified certain predisposing factors such as working hours, evisceration and cut-up task, and smoking related to risk of WMS to upper limb and neck region among poultry slaughterhouse workers.
      PubDate: 2022-07-21
  • A10. Measuring Movements 24 Hours per Day in Older Persons Living in a
           Nursing Home - A Pilot Study

    • Authors: Yadanuch Boonyaratana, Eva Ekvall Hansson
      Pages: 43 - 43
      Abstract: Background: Physical activity plays a crucial role in maintaining function and movement in daily life among nursing home residents. Modern technology allows research on physical activity and gait parameters measured with mobile devices and for a long time. The purpose of this study was to describe physical activity, sedentary time and gait parameters among nursing home residents.  Methods: Five participants, ranging in age from 75 to 98 years old were recruited at a nursing home in Lund, Sweden to control the environment (median 88 years old). Over a two-week period, the Inertial Measurement Unit (IMU) device was used to measure various position changes and gait function for 24 hours.We specifically measured lying down, sitting and standing time, as well as gait parameters such as walking speed, step length, step regularity, and number of steps per day. The variables were described using mean, median, minimum-maximum, and percentage values.  Results: The median of mean values for all lying down at 6 hours and 17 minutes. In particular, side-lying position was 22 hours and 22 minutes, including sitting position of 7 hours and 39 minutes among nursing home residents. The gait parameters were represented by a median of mean value elements of walking speed was 0.35 m/s, step length was 18.55 cm, and the number of steps was 65 steps per day. Nevertheless, the median of mean value for step regularity was illustrated in high percentages at 71.43.  Conclusion: Time spent in lying down and sitting positions for more than three hours indicated lack of physical activity and high level of sedentary behavior in nursing home residents and also had a poor walking ability corroborating the logical theory of aging. Hence, the findings are able to enhance physical activity and gait function among nursing home residents further. 
      PubDate: 2022-07-21
  • A11. Occurrence of Musculoskeletal Health Complaints and Corresponding
           Risk Factors among Music Students and Non-music Students – Results from
           a Prospective Cohort Study

    • Authors: Nikolaus Ballenberger, Florian Avermann, Natalie Pankrath, Svenja Nilsson, Dirk Möller, Christoff Zalpour
      Pages: 44 - 44
      Abstract: Introduction: Musculoskeletal complaints (MHC) in professional musicians are common but a lack of prospective studies in the field of music medicine, identification of causal relations in the etiology of musculoskeletal disorders in instrumental musicians is challenging.  Objectives: A prospective cohort study was launched with 1) determining the prevalence of MHC among music students 2) to compare the physical and mental health of music students and non-music students at the start of the study 3) identify risk variables for MHC, and 4) develop an MHC prediction model in musicians. Methods: The measurements consisted of a self-designed questionnaire addressing history of pain, localization of pain, habits, practicing and sports, validated questionnaires measuring health related QuoL (SF12), stress symptoms (SCI), and performance anxiety (KMPAI) and physical examination including core stability, hypermobility, cervical range of motion, mechanosensitive. Occurrences (incidence and prevalence) of MHC were recorded monthly by online questionnaires. Results: 278 are included for the cross-sectional comparison and 149 for the longitudinal analysis so far. The monthly and yearly prevalence of MHC was 27% and 56% respectively. Yearly incidence rate was 29%. The number of stress symptoms and mechanosensitive were considerably increased (p<0.05) in music students compared to non-music students, but physical and mental health, physical activity, and general cervical CROM were dramatically decreased (p<0.05). Longitudinal analysis, significant risk factors for the development of MHC within one year were being a music student, increased bodily pain, history of complaints, higher number of stress symptoms, reduced physical and mental health, and history of smoking (p<0.05). Furthermore, a set of mainly pain and physical health related variables including smoking showed good ability in predicting MHC (AUC=0.74). Conclusion: In further cohorts the results need to be replicated. Additionally, occurrences and risk factors of MHC will be analyzed body region and instrument specific.
      PubDate: 2022-07-21
  • A12. Effects of Modified-OTAGO on Body Composition in Older Adults during
           COVID-19 Outbreak: A Preliminary Study

    • Authors: Nichapa Khumpanaid, Theerapat Phoka, Surasa Khongprasert
      Pages: 45 - 45
      Abstract: Introduction: Aging is characterized by an unavoidable decline in body composition, including changes in muscle mass, muscle quality, and adiposity. These compartments contribute to falls, a major health issue that causes serious injuries and death. The COVID-19 outbreak causes long-term quarantine, which limits outdoor activity leading to physical inactivity. As a result, it worsens body composition declination, raising the risk of falls. The Otago Exercise Program (OEP) is widely used to prevent falls. However, it is time-consuming and requires additional walks to get better efficacy.  Objective: This study aims to investigate the effects of modified-OEP on body composition in community-dwelling older adults.       Methods: This study was a double-blinded randomized control trial. Participants aged 60-80-year-olds were randomly assigned to the modified-OEP or control group. The modified OEP group performed a 60-minute session consisting of 40-minutes OEP and 20-minutes walking, while no intervention was assigned to the control group. Body composition was assessed before and 6 weeks after intervention using Dual Energy X-ray Absorptiometry (DEXA). Repeated measures two-way ANOVA was employed for statistical analysis. Results: After 6 weeks of interventions, the modified-OEP group had a significant decrease in leg fat mass (p = 0.0008), total fat mass (p= 0.0036), and total tissue percent fat (p = 0.0320). These observations were not observed in the control group, indicating the efficacy of the modified-OEP. In comparison between groups, the modified-OEP did not show a statistical difference from the control. However, we observed an improvement trend in lean mass and fat-free. Conclusion: We demonstrated that the modified-OEP can significantly reduce fat in as little as six weeks. Further investigation should explore the long-term efficacy of such a program.
      PubDate: 2022-07-21
  • A14. Knowledge, Awareness, and Practice Regarding Pesticide Exposure and
           Health Symptoms among Farmers

    • Authors: Ajchamon Thammachai, Ratana Sapbamrer, Juthasiri Rohitrattana, Siam Tongprasert, Surat Hongsibsong, Kampanat Wangsan
      Pages: 47 - 47
      Abstract: Introduction: Pesticides are widely used to control agricultural insects in Thailand. Farmers have an opportunity to be exposed to high doses of pesticides. The improper pesticide application may also have resulted in adverse health effects. Objective: This study aimed to investigate the association between farmers’ knowledge, awareness, and practices regarding pesticide use and health symptoms related to pesticide exposure. Methods: A cross-sectional study was conducted among farmers in Chiang Dao district, Chiang Mai province. A validated questionnaire was adapted, and 328 farmers were recruited. Data were analyzed using descriptive statistics, the Chi-Square test, and Fisher's exact test. Results: About 71.0% of the farmers were males, with a mean age of 53.04 ± 11.72 years old. Farmers had the lowest knowledge of pesticide container disposal (44.5%), pesticide mixing as a label recommendation (50.3%), and the entry route of pesticides (51.8%). The lowest awareness scores were for using personal protective equipment (PPE) while applying pesticides (23.5%), followed by wearing PPE while applying pesticides (64.6%) and washing spray tanks in a river or waterway (82.0%). Changing clothing immediately after pesticide application received the lowest score (6.7%), followed by wearing goggles during pesticide application (14.9%) and showering soon after pesticide application (15.5%). The farmers complained that they had experienced symptoms such as headaches (29.6%), fatigue (20.4%), blurred vision (19.8%), eye irritation (18.3%), and dizziness (14.6%). Farmers who mixed pesticides with their bare hands reported a higher prevalence of headaches (OR = 0.56, 95% CI = 0.33-0.92), itchy (OR = 0.37, 95% CI = 0.19-0.71), and blurred vision (OR = 2.22, 95% CI = 1.11-4.47).  Conclusion: Farmers' health-prevention practices need to be improved, as well as their knowledge and awareness. As a result, farmers must receive continuous pesticide safety education, and also training in the use of PPE during and after pesticide application.
      PubDate: 2022-07-21
  • A16. Development of Alcohol Behavioral Assessment Tool for Hill Tribe
           Adolescents: Validity and Reliability of the Tool

    • Authors: Ritichai Pimpa, Chatchada Sutalangka, Kiatnarong Manosuk, Suttida Chaisinlapin, Janya Chuadthong, Tawatchai Apidachkul
      Pages: 49 - 49
      Abstract: Introduction: Drinking alcohol is a significant health behavior that should be changed. Hill tribe adolescents face a significant increase in the number of new drinkers. Changes in alcohol drinking behavior among hill tribe adolescents must be carried out according to the factors measured by quality measuring tools.  Objective: This research aims to study the validity and reliability of an alcohol behavioral assessment tool for hill tribe adolescents to help evaluate their drinking alcohol behavior. Methods: Mixed Methods are divided into qualitative and quantitative research. In-depth interviewers collected the hermeneutic phenomenology data. The Lahu tribe village and the informants were selected for convenience sampling. They are three drinking and three non-drinking Lahu tribe adolescents, one community leader, two health promotion hospital staff, two village health volunteers, two youth parents, and two youth friends. The data was analyzed by Leonard’s method and applied to PRECEDE MODEL. Five experts validated the content validity based on the index of item-objective congruence (IOC). In terms of internal consistency reliability, it was calculated by Cronbach's alpha coefficient from the experimental survey of 30 hill tribe adolescents. Results: The assessment tool was divided into 6 parts: 1) Population characteristics questionnaire, 2) Alcohol drinking behavior interview form, 3) Predisposing factors in alcohol knowledge questionnaire, 4) Predisposing factors in beliefs about drinking alcohol questionnaire, 5) Predisposing factors in values about drinking alcohol questionnaire, and 6) Reinforcing factors and enabling factors questionnaire. The quality of the tool in terms of content validity, IOC of edited parts 1 - 5 was 0.81 - 1.00. Regarding reliability, Cronbach’s Alpha Coefficient of edited parts 3-5 were 0.70, 0.78, and 0.70, respectively. Conclusion: The alcohol behavioral assessment tool for hill tribe adolescents was consistent with the content validity and reliability according to the specified criteria. It will allow researchers to accurately assess drinking behavior and use the information to plan further health behavior change programs.
      PubDate: 2022-07-21
  • A17. Proliferation and Survival Enhancing Effect of Pinocembrin on
           Immortal Human Epidermal Cells

    • Authors: Jirapak Ruttanapattanakul, Nitwara Wikan, Saranyapin Potikanond, Wutigri Nimlamool
      Pages: 50 - 50
      Abstract: Introduction: Pinocembrin is one of the active compounds that is found in many plants, mostly in the Zingiberaceae family. Previous studies reported that pinocembrin possesses wound healing enhancing activities. However, the wound healing-promoting activities of pinocembrin in human cell lines have not been fully elucidated; especially for the aspect associated with the growth and survival signaling pathways. Objective: To investigate possible molecular mechanisms of pinocembrin in enhancing growth and survival signaling pathways in human keratinocytes Methods: Immortal human keratinocyte cell line (HaCaT) was used as an in vitro model. Western Blot analysis and immunofluorescence techniques were used to investigate the molecular mechanisms of pinocembrin. Specific inhibitors of proliferation and survival signaling cascades, which were U0126 and LY294002, were also used for confirming the mechanism of pinocembrin. Results: Pinocembrin activated ERK1/2 and Akt phosphorylation which play important roles in growth and survival signaling pathways, respectively. The effects were seen in dose-dependent fashion. Moreover, MEK inhibitor (U0126) and PI3K inhibitor (LY294002) confirmed that pinocembrin induces proliferation and survival through stimulating the MAPK and PI3K/Akt signaling pathways. Conclusion: Pinocembrin induces the proliferation and survival of human keratinocyte cells. Its mode of action is mediated through the activation of ERK1/2 and Akt which typically function in maintaining cellular proliferation and survival. In summary, the current study supports the wound healing-enhancing effect of pinocembrin at the molecular level and further supports its potential therapeutic applications for skin regeneration.
      PubDate: 2022-07-21
  • A18. The Anti-cancer Effects of Oxyresveratrol on Ovarian Cancer Cell
           Lines via Negative Regulation of AKT Activation Status

    • Authors: Phatarawat Thakaewphan, Nitwara Wikan, Saranyapin Potikanond, Wutigri Nimlamool
      Pages: 51 - 51
      Abstract: Introduction: Oxyresveratrol has been reported that inhibits the survival signaling and has anti-cancer effects on various cancers. However, the difference in the cancer genotype typically influences the responsiveness to anti-cancer agents. Therefore, comparative observation for the response sensitivity to Oxyresveratrol should be determined. Oxyresveratrol was tested in different ovarian cancer cell types for its cytotoxic effects, the expression level of pro-apoptotic and anti-apoptotic proteins, and the inhibitory influence on survival signaling pathway. Objective: To investigate the anti-cancer effects of oxyresveratrol on different types of ovarian cancers and identify the possible mechanisms of oxyresveratrol. Methods: Oxyresveratrol was tested in three different ovarian cancer cell lines, A2780, SKOV3, and TOV21G. Cytotoxic effect was evaluated by MTT, and western blot was used to determine the level of pro-apoptotic proteins, anti-apoptotic proteins, and key molecules in survival signaling transduction. Cisplatin was used as a standard chemotherapy to determine the efficacy of the combinational treatment. Results: Oxyresveratrol induced cell apoptosis in A2780 and SKOV3, reduced anti-apoptotic protein levels, and activated the expression of pro-apoptotic proteins. Moreover, oxyresveratrol inhibited phosphorylation of AKT and PDK-1 without any effect on the phosphorylation status of ERK1/2. In combination with cisplatin, oxyresveratrol amplified the efficacy of the drug to induce cell death in SKOV3, generally resistant to cisplatin. Conclusion: Oxyresveratrol inhibits cancer cell apoptosis via reduction of PI3K-AKT transduction, and that decreases the level of anti-apoptotic proteins and activates cell apoptosis. Moreover, oxyresveratrol combined with a standard chemotherapy can amplify the death-inducing efficacy in resistant cells.
      PubDate: 2022-07-21
  • A19. Discriminative Ability of the 7th Cervical Vertebral Wall Distance
           for Hyperkyphosis Measurement in Elderly

    • Authors: Patcharawan Suwannarat, Sugalya Amatachaya, Pipatana Amatachaya, Supapon Kaewsanmung, Ampha Pumpho
      Pages: 52 - 52
      Abstract: Introduction: Hyperkyphosis is an excessive thoracic spine curvature exceeding 40 degrees, which can lead to many adverse health and other health-related consequences. Currently, the 7th cervical vertebra wall distance (C7WD) is a practical, valid, and reliable measure to screen and monitor thoracic hyperkyphosis in the elderly. The C7WD is at least 7.5 cm. could indicate the risk of hyperkyphosis in elderly. However, there is no clear evidence to confirm the clinical utility of the measurement as a discriminative ability of the C7WD.  Objective: To investigate discriminative ability of hyperkyphosis severity using C7WD in the elderly Methods: This study was conducted in 90 participants, aged at least 60 years from several communities who had different degrees of thoracic hyperkyphosis. All participants were assessed for their severity of thoracic hyperkyphosis using the C7WD and a lateral plain radiograph (Cobb’s method). Hyperkyphotic elderly was defined using Cobb angle of at least 40 degrees and C7WD of at least 7.5 cm. Results: Participants were divided into 2 groups including normal group (C7WD less than 7.5 cm and hyperkyphosis group (C7WD at least 7.5 cm). The finding showed the significance difference of C7WD and Cobb angle between the normal (C7WD 3.57±2.59 cm, and Cobb angle 32.84±4.54) and hyperkyphosis group (C7WD 9.26±3.05 cm, and Cobb angle 46.13±5.15) (p<0.001).  Conclusion: The finding suggested that the C7WD was a simple method for hyperkyphosis screening in which elderly with the C7WD at least 7.5 cm may be an initial hyperkyphosis.
      PubDate: 2022-07-21
  • A20. Comparison of Executive Function in Male Puberty and Andropause

    • Authors: Chatchada Sutalangka, Nachada Taechasubamorn, Arisa Sonsiri, Nutcha Kasematicha, Wilawan Chaiut, Ploypailin Namkorn, Janya Chuadthong, Ritichai Pimpa, Niran Ngernyam
      Pages: 53 - 53
      Abstract: Introduction: Andropause or male menopause is associated with a decrease in executive function, activity, daily living performance, and quality of life. However, no study reported the executive function skill in andropause or male menopause.  Objective: To compare the executive function in male puberty and andropause in five skills, including mental flexibility, inhibitory control, verbal fluency, working memory, and planning. Methods: 18 male puberty and 13 andropause underwent executive function test including mental flexibility by D-KEFS sorting test, verbal fluency by verbal fluency test, inhibitory control by Stroop test, working memory by trail making test part B and planning by D-KEFS tower test. Statistical analysis by Independent–sample t-test in normal distribution and Mann-Whitney U test in non-normal distribution and p-value is 0.05. Results: In the male puberty group average age is 20.17 ± 0.79 years old, and in the andropause group, the average age is 48.54 ± 5.52 years old. This study found that there are 3 tests that showed significant statistical differences (P<0.05) between groups, including mental flexibility (p=0.002), verbal fluency (P<0.001), and inhibitory control (P<0.001). However, there are two tests that showed no significant statistical difference, including working memory (P=0.068) and planning (P=0.170). Conclusion: Executive function, including mental flexibility, verbal fluency, and inhibitory control in andropause, was significantly less than the male puberty group. Therefore, executive functioning skills in andropause should be concerned with preparing for aging. 
      PubDate: 2022-07-21
  • A22. The Short Time Effect of Kinesio Taping on Back Muscle Endurance,
           Lower Back Flexibility and Balance in Sedentary Young Adult

    • Authors: Ekalak Sitthipornvorakul, Thammathorn Techapisith, Pandharee Supraphakorn, Waramporn Worajittakul, Ploypailin Namkorn
      Pages: 55 - 55
      Abstract: Background: A sedentary lifestyle was often experience problems with the musculoskeletal system. Less physical activity will reduce the capability of the muscles. Moreover, it can cause pain or diseases related to the musculoskeletal system. Therefore, this study aimed to examine the effect of Kinesio taping on back muscle endurance, lower back flexibility and balance in sedentary young adults. Method: This study was a randomized controlled trial, 44 sedentary young adults were selected and subjects were randomly assigned into two groups, the KT group and the control group. Each group included 22 subjects, they were assessed before the taping intervention of Schober's test, Single stance test, Y-balance test and Biering-Sorensen test. After the taping intervention 30 minute, subjects were recorded using the same test method. Result: There was a statistically significant increase of single leg stance in the KT group compared to the control group (p ≤0.05). In other tests, the KT group was significantly increased compared to before and after the experiment. On the other hand, the flexibility of the back had a statistically significant decrease in the KT group. Besides, there was no significant difference of the flexibility of back between in the KT group and the control group. Conclusion: In this study found that the kinesio tape can increase capability of balance in people with sedentary behavior with statistical significance. Due to kinesio tape can increase the sensory response in the area where the tape is attached. This result shows Kinesio taping seems to have an effect on perception and the ability of the nervous system and muscles to control movement.
      PubDate: 2022-07-21
  • A24. Antimicrobial Activities of Streblus Asper Leaves Extract in Thailand

    • Authors: Potchara Yuthchana, Pisanrat Tanapornsiri, Pavisa Tosakun, Sauwarin Thongsri, Kalyanee Yutthakosa, Chutinan Suksaard, Aunyachulee Ganogpichayagrai
      Pages: 57 - 57
      Abstract: Introduction: Streblus asper, or toothbrush tree, has been traditionally used as a medicinal plant for toothache and dental caries treatments. Objective: This study aimed to investigate antimicrobial activities of S. asper leaves ethanolic extracts in Thailand. Methods: S. asper leaves were washed, dried and ground to powdered, then exhaustively extracted with 95% ethanol using Soxhlet extraction. Antimicrobial activity including determined zone of inhibition, determination of minimum inhibitory concentration (MIC), determination of minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined, as according to Clinical & Laboratory Standards Institute guidelines. The extract was done against 10 tested microorganisms including, Staphylococcus aureus, Bacillus cereus, Streptococcus mutan, Enterobacter aerogenes, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Candida glabrata. Results: S. asper leaves extract at 200 mg/ml showed an inhibition zone against tested microorganisms, except Pseudomonas aeruginosa, ranging from 7.00 to 11.00 mm. The leaves extract had inhibitory and microbicidal capacity at concentration of            ≥ 2,000 µg/ml, except Staphylococcus aureus and Streptococcus mutan had good inhibitory and microbicidal capacity at concentration of 125 and 250 µg/ml, respectively. Conclusion: S. asper leaves extract had good activities on oral pathogen bacteria, its leaves extract could be beneficial as an oral hygiene product.
      PubDate: 2022-07-21
  • B01. Effectiveness of Huangqi Guizhi Wuwu Decoction on Adult Diabetic
           Neuropathic: A Systematic Review

    • Authors: Jia Wei Chin, Kitthiphum Ruangravevat, Raksuda Taniguchi, Piyapach Thongprew, Sinee Tantasatiyanon
      Pages: 58 - 58
      Abstract: Introduction: Chinese herbal medicine formula Huangqi Guizhi Wuwu decoction (HGWD) is commonly used for arthritis, spondylosis, stroke, etc. Previous research showed that HGWD also suggested diabetic neuropathic (DNP) treatment Objective: To evaluate the effectiveness and safety of HGWD in treating adult DNP. Methods: Six databases, including Pubmed, Cochrane Library, EMBASE, China Network Knowledge Infrastructure (CNKI), Wanfang, and Chinese Scientific Journals were searched from their inception to May 2022. Only randomized control trials (RCTs) that evaluated HGWD for adult DNP were included in this review. Two investigators independently evaluated and extracted the data. Results: A total of 181 RCTs and 15,657 participants were included in the review. In these studies, oral HGWD single used or HGWD combined with oral drugs were compared with oral methylcobalamin, epalrestat, etc., single used. The outcomes of effective rate and adverse events were analyzed. The effective rate of HGWD is higher than other pharmacotherapies (RR:4.50, 95% CI [4.09,4.96], P < 0.05). The results showed the intervention group had fewer adverse events (RR: 0.54, 95% CI [0.34, 0.86], P < 0.05), which included nausea, abnormal liver and kidney function, gastrointestinal overreaction, etc. Conclusion: The meta-analysis results showed that HGWD is effective and brings fewer adverse events to adult DNP. It is recommended in treating DNP, but further research about the mechanism is necessary for deeper understanding.
      PubDate: 2022-07-21
  • B02. Therapeutic Efficacy of Knee Acupuncture added Sanyinjiao (SP6)
           Acupoint for Pain Reduction in Knee Osteoarthritis Patients

    • Authors: Warangkhana Klajing, Yin Shen Tan, Pongnared Jaengpromma, Anongporn Kobroob
      Pages: 59 - 59
      Abstract: Introduction: Osteoarthritis is one of the musculoskeletal changes in the elderly, which is involved in the degradation of the cartilage, and bone remodeling in the affected joint.  Inflammation was also associated with osteoarthritis of the knee.  Therapeutic strategies that alleviate inflammation could reduce pain and improve knee motion.  Previous studies have reported that traditional knee acupuncture could reduce pain and improve knee motion.  However, the therapeutic efficacy of traditional knee acupuncture added Sanyinjiao (SP6) acupoint is still unknown. Objective: This study was to investigate the effects of knee acupuncture added Sanyinjiao (SP6) acupoint on pain, inflammation, and knee joint motions. We hypothesized that acupuncture could reduce pain, inflammation and lead to improved joint motions. Methods: 15 patients were enrolled.  All patients received acupuncture for 10-sessions, 2 times a week for 5 weeks.  Pain visual analog scale (VAS), knee motion, and plasma hs-CRP were determined as a baseline and at the end of the treatment protocol.  Results: 78% were female, aged ranging from 60 to 75 years old.  After 10 treatment sessions, an improvement in the flexion and extension were found accordingly with a reduction in knee pain.  In addition, plasma hs-CRP was significantly decreased (1.64 ± 0.89 mg/dL vs. 4.32 ± 0.56 mg/dL at baseline, respectively). Conclusion: Knee acupuncture added SP6 point could improve knee motion and decrease pain through a reduction of inflammations.
      PubDate: 2022-07-21
  • B03. Anti-Inflammatory Effect of Folk Remedy for Hemorrhoids Treatment

    • Authors: Kanyarat Peng-ngummuang, Piyaporn Thorajake, Jaknarin Dokmaiphet, Charanya Thongsing, Phanida Kamuttachat, Jintana Junlatat
      Pages: 60 - 60
      Abstract: Introduction: Mr. Kitti Nakun, a well-known folk healer in Ubon Ratchathani province. Nowadays, hemorrhoids are one of the many diseases that he treats patients with herbal medicine. The hemorrhoids treatment remedy of Mr. Kitti Nakun consisted of 4 herbs including Salacia chinensis L., Salacia verrucose Wight., Curcuma comosa Roxb., and Cissus quadrangularis L.   Objective: The objective of this research was to study the anti-inflammatory activity of extract from a hemorrhoid treatment remedy of Mr. Kitti Nakun. Methods: The remedy was extracted with water and freeze-dried. Then, the extract was tested for cytotoxicity on macrophages (RAW264.7 cells). The anti-inflammatory effect was examined via the nitric oxide production by using Griess reagent and the inflammatory-related genes by using semi-quantitative reverse transcription and polymerase chain reaction technique in lipopolysaccharide-induced cells.  Results: The results showed that the extract had a low cytotoxicity with the cell growth inhibitory concentration (IC50) greater than 1000 µg/mL. Moreover, the anti-inflammatory activity test with Griess reagent demonstrated that the extract at a concentration of 200 µg/mL was able to inhibit nitric oxide secretion by 46.38%. In addition, the extract at concentration of 50-200 µg/mL were able to inhibit cyclooxygenase-2 and tumor necrosis factor-α gene expression in a dose dependent manner. Conclusion: The information of this study is very important and useful in promoting the wisdom of folk healers to be recognized and further developed.
      PubDate: 2022-07-21
  • B04. The Protective Effect of Thai Herbal Wattana Formula on Chronic
           Cerebral Hypoperfusion Induced by Bilateral Common Carotid Artery Ligation

    • Authors: Namphung Thongta, Sarayut Vattananupon, Pichanon Wacharaprapapong, Anchalee Attarakorn, Pravit Akarasereenont, Suveerawan Limsuvan, Kanokwan Tilokskulchai, Sompol Tepechum, Narawut Pakaprot
      Pages: 61 - 61
      Abstract: Introduction: As the association between cognitive impairment and cerebral hypoperfusion in different types of dementia has been established, it is important to unravel the hypoperfusion-related neurodegenerative and cognitive correlates. Components of Thai herbal Wattana formula (WNF) have been proven to exhibit anti-oxidant and anti-inflammatory actions and to reduce amyloid pathology-related neurotoxicity and cognitive dysfunction. Objective: We aimed to explore neuroprotective effects of WNF in the 2-VO (2 vessel occlusion) model and to examine its therapeutic potential as an alternative option for chronic cerebral hypoperfusion (CCH). Methods: The adult male Wistar rats (n=5/group) underwent bilateral common carotid artery ligation. The WNF recipe (300 mg/kg) was administered orally after surgery for 60 days. The Morris Water Maze test was performed between day 61 and 70 followed by Cresyl Violet staining of the brain tissue on day 71. Results: We found that WNF tended to aid memory retrieval (p < 0.6396, 2-VO versus 2-VO + WNF) but did not improve memory acquisition after CCH (p < 0.0997, 2-VO versus 2-VO + WNF). The impaired survival of neurons was improved by WNF in the right CA3 subregion (p < 0.05 2-VO versus 2-VO +WNF). Conclusion: This will be the first time that our study explored the potential therapeutic efficacy of WNF and opened a therapeutic window to ameliorate neurodegeneration in conditions that cause CCH such as vascular dementia.
      PubDate: 2022-07-21
  • B05. The Effects of Orange, Sweet Basil, and Dok Mok Essential Oils
           Inhalation on Emotional State and Autonomic Nervous System

    • Authors: Nongnapat Leelasithorn
      Pages: 62 - 62
      Abstract: Introduction: Chronic stress can be detrimental to both physical and mental health. Since essential oils (EOs) from herbs have been shown to activate the nervous system by sending an electric signal to limbuc system modulating behavioral and emotional responses, and reversing a stress-induced change in both nervous system and hormone secretion.  EOs from three Thai native medical herbs - Citrus reticulata Blanco (Orange), Wrightia religiosa (DokMok), and Ocimum basilicum L. (SweetBasil) - are also used as aromatherapy to alleviate stress in Thai society for ages. Orange EO, DokMok EO, and SweetBasil EO contain limonene, linalool, and linalool & eugenol respectively which are reported anti-stress, anti-anxiety, and anti-depression effects.
      Objective: This study aimed to investigate the effects of the three herbs EOs on the autonomic nervous system (ANS) and emotional states.
      Methods: In this study, Orange EO is extracted by a cold press machine. DokMok EO is extracted by solvent extraction. SweetBasil EO is extracted by steam distillation. Twelve healthy volunteers consented to participate in the experiment, and were assessed blood pressure and heart rate to determine the arousal level of the ANS. Besides, the participants filled out a questionnaire on emotional states before and after the 20-minute inhalation of aroma samples. Data were analyzed using paired sample t-tests. Means of the blood pressure, heart rate, and emotional states of subjects were compared before and after the inhalation. 
      Results: The results showed that, in terms of ANS, the heart rate mean was significantly decreased after the inhalation (p<0.05) while the blood pressure mean did not show any statistically significant decrease. The mean of emotional state scores inputted by the subjects was significantly improved (P<0.05). 
      Conclusion: This study demonstrated that aromatherapy from Orange, DokMok, and SweetBasil seems to have effects on ANS regulation and positive emotional states. However, further studies are needed.

      PubDate: 2022-07-21
  • B06. Role of Intravenous Glutathione and High-dose Vitamin C in Adult
           Acute Lymphoblastic Leukemia Adjunctive Therapy

    • Authors: Natchanun Phunthanateerakul, Angela Hardin
      Pages: 63 - 63
      Abstract: Introduction: Acute lymphoblastic leukemia (ALL) is rare and has poor prognosis in older adults. The challenging aspect of ALL management in adults is that the patient and leukemic factors are imperative components when designing the treatment regimen. Intravenous (IV) therapy increases bioavailability beyond oral administration and is one of the essential treatments utilized among licensed Naturopathic doctors (NDs). Glutathione (GSH) plays an important role in multiple pathways of programmed cell death, particularly in apoptosis. High-dose intravenous vitamin C (HDIVC) enhances immune function. This case report discussed an adult patient with ALL who received IV therapy while waiting for allogeneic stem cell transplantation (allo-SCT), one of the standard treatments to achieve remission.  Objective: The aim was to evaluate the effectiveness of IV GSH and HDIVC for an adult with ALL as adjunctive therapy. Methods: A 43-year-old Hispanic female with an ALL relapse. The patient was a good candidate for allo-SCT. She was simultaneously treated with oral chemotherapy, while receiving adjunctive therapy, including multi-nutrients IV drips followed by a GSH push, HDIVC, nutraceuticals, botanicals, homeopathy, and nutritional counseling. We evaluated the effectiveness of the treatment regimen using subjective and objective measures: (1) blood pressure, (2) blood glucose, (3) energy rating scale, and (4) quality of life. Results: IV multi-nutrient drip with GSH push alternated with HDIVC administered bi-weekly helped reduce fatigue and improved quality of life in this patient. No adverse events reported. However, the complete remission of ALL was delayed mainly due to the lack of insurance and the uniquely challenging pandemic related to coronavirus disease 2019 (COVID-19). Conclusion: IV GSH and HDIVC are proven to be effective and safe adjunctive treatments to improve quality of life and extend life of an adult patient with ALL. This treatment regimen deserves consideration as an adjunctive therapy for similar patients.
      PubDate: 2022-07-21
  • B07. The Effect of External-Focused Attention Using the Prototype Model of
           SCF Innovation (Speedy Colors Fitting) on Postural Control in Healthy
           Young Adults

    • Authors: Ploypailin Namkorn, Butsayaphan Sorensen, Tanpitcha Buayen, Anchisa Intanop, Wilawan Chai-ut, Kitiyawadee Srisim, Chatchada Sutalangka
      Pages: 64 - 64
      Abstract: Introduction: Postural control is the ability to control the body’s position and is an important fundamental factor for daily living activities, which requires coordination between an object and upper extremity while maintaining the body’s position depends on postural control. The prototype model of SCF (Speedy Colors Fitting) innovation was invented to train postural control by stimulating the coordination between eyes and hands for enhancing cognition through using symbols and colors as external stimuli simultaneously with using the random pattern of colors as choice reaction time.  Objective: This study aimed to study the effect of external-focused attention using a prototype model of SCF (Speedy Colors Fitting) innovation on postural control. Methods: This study is a quasi-experimental design. Ten healthy participants were recruited, and all were trained in postural control by the SCF innovation prototype model. Participants completed static balance in multiple conditions, including a quiet stance with eye closed and eye open. Dynamic balance tests were performed on the functional reach and the timed-up and go test with a wearable movement sensor (APDM). Data were recorded as outcomes; center of pressure (COP) path length, COP velocity, unilateral duration, turn angle, turn duration, and sit-to-stand duration before and after training.  Results: After training with the prototype model of SCF innovation, the COP path length of static balance in each condition did not significantly increase. The dynamic balance decreased with no statistical significance. COP velocity increased in static balance, dynamic balance, and functional reach with no statistically significant difference. Timed-up and go test variables decreased after training with no statistical significance (p-value = 0.092). The functional reach test found that participants could reach further after training (p-value = 0.139). However, there was no statistically significant difference between before and after training. Conclusion: Providing external-focused attention by prototype model of SCF innovation on postural control in healthy young adults could enhance the ability to control the body’s position while in motion or dynamic balance.
      PubDate: 2022-07-21
  • C01. Analysis of the clinical therapeutic effect of Professor Wang Yue on
           42 cases of Sjogren's syndrome overlaps with Hashimoto's

    • Authors: Wachiraporn Padungkiettiwong, Wang Yue, Haiying Guo , Ho Sau Man Vivi
      Pages: 65 - 68
      Abstract: Introduction: Clinical work and reports in the past ten years have found abnormal thyroid function in many patients with Sjögren's syndrome (SS), and Hashimoto's thyroiditis (HT) is the most common. Both are Autoimmune diseases, and there is currently no effective treatment. Traditional Chinese Medicine can effectively improve patients' clinical symptoms and laboratory indicators through syndrome differentiation, treatment, and holism modulating.  Objective: To examine the TCM method of differentiation, treatment, medication characteristic, and clinical effect of Professor Wang Yue in treating primary Sjogren's syndrome overlap with Hashimoto's thyroiditis (SS-HT). Methods: 42 cases with SS-HT from the outpatient department of Professor Wang Yue of Nanjing Affiliated Hospital of traditional Chinese medicine between January 2015 to August 2020 were selected. Excel 2010 was used to collect and frequency analysis the general data, syndrome types, and medication characteristics of Professor Wang Yue in treating SS-HT, and used SPSS 24.0 software to statistically analyzed the TCM syndrome score and laboratory index before and after treatment.  Results: Professor Wang Yue mainly treated SS-HT by replenishing Qi and nourishing Yin, generating fluid and relieving thirst, clearing heat and purging fire, reducing swelling, and dispersing knots. Six cases were markedly effective, 15 cases were improved, 19 were effective, and two were ineffective. The total efficiency was 95.24%. After treatment, TCM syndrome score decreased significantly (P < 0.01), CRP, ESR, TGAb, TPOAb decreased significantly (P < 0.01).   Conclusion: SS-HT's pathogenesis is Yin deficiency and internal heat in the first stage. In the middle stage is both Qi and Yin deficiency, and liver and kidney Yin deficiency are in the late stage. SS-HT treatment method moistens the lung and clears the stomach heat, replenishing Qi and Yin, tonifying the liver and kidney, and reducing swelling and dispersing knots. Chinese Medicine treatment of SS-HT has a definite curative effect: it can relieve clinical symptoms and reduce the inflammatory index and thyroid autoantibody without side effects, including anti-inflammatory, analgesic, anticoagulation, immune regulation, liver, and kidney protection. It is worthy of clinical application.
      PubDate: 2022-07-21
  • C03. Research progress in the treatment of Lumbar Disc Herniation with
           special acupuncture therapy

    • Authors: Pitchayut Chambumrung, Pastraporn Khonburee, Thanatthep Terathaweedoun
      Pages: 74 - 77
      Abstract: Lumbar disc herniation (LDH) refers to a clinical syndrome in which the nerve root and cauda equina nerve are stimulated or compressed by the protruding intervertebral disc tissue on the pathological basis of LDH. Its clinical manifestations are low back pain, lower limb radiation pain, lower limb numbness and weakness, stool and urination dysfunction, etc. Most patients with lumbar disc herniation can improve their symptoms after conservative treatment. For those patients without significant nerve damage, the preferred treatment should be non-surgical treatment. There are many records about low back pain in traditional Chinese medicine literature, which are scattered in the discussion of "low back pain", "waist and foot pain", "waist and leg pain", "arthralgia syndrome" and other diseases and syndromes. Moreover, there are many kinds of therapies, especially the use of special acupuncture and moxibustion therapy for LDH has a good curative effect. Among them, all kinds of therapies have their own characteristics and continue to develop to the present. This paper introduces some literature reviews on the application of special acupuncture therapy in the treatment of LDH for reference, and the contents are summarized as follows.
      PubDate: 2022-07-21
  • C08. The Effectiveness of Thai Massage on the Range of Motion and Muscular
           Strength of the Arm in Collegiate Basketball Players, Mae Fah Luang

    • Authors: Sirikool Klumkool, Vassana Charoonsrisawad, Tanyarath Tapcompill, Kawiya Sintara, Chirapan Nakhanakhup, Supaporm Wisungre, Duangkamol Thammapatanakul, Bupachat Petcharat, Rossukon Tatan
      Pages: 98 - 103
      Abstract: Introduction: Basketball is a fast pace sport, where the players are required to move quickly, catch and shoot the ball. Basketball players have been developed various techniques using upper limbs such as shooting, throwing, passing, and dribbling. In addition to exercise training for high level of physical fitness, sports massage with stimulating technique is also using for the short-term effectiveness. Objective: The purpose of this study was to determine the effectiveness of Thai massage on the range of motion (ROM) of the right shoulder and muscular strength of the right arm in the collegiate basketball players. Methods: Twenty subjects, aged from 19 to 24 years old, were equally randomized into two groups: Thai massage group was treated with Thai Massage program and control group was treated with Swedish massage program for 10 minutes. Shoulder ROM and grip strength were measured immediately before the intervention, and after the intervention. The duration of the trial was 2 times, with the first trial - two days off - the second trial. Results: The results showed that Thai massage program improved range of motion of the right shoulder. Data showed a significant difference in shoulder abduction (p<0.05) and adduction (p<0.05) compared with control group. Additionally, Thai massage program significantly promoted short-term effect on muscular strength of the right arm (p<0.05) compared with control group in 2 trials. Conclusion: These results suggested that the Thai massage program has an short-term effects on the range of motion of the right shoulder and muscular strength of the right arm, compared to Swedish massage in the control group.
      PubDate: 2022-07-21
  • C09. Effect of Court-Type Thai Traditional Massage Versus Cassia alata
           Linn. Treatment on Chronic Constipation: A Randomized Controlled Trial

    • Authors: Panada Ramphaiboon, Nawatpong Chairat, Phanida Wamontree, Vitsarut Buttagat
      Pages: 104 - 108
      Abstract: Introduction: 24 percent of the Thai population thinks they have constipation, it was found that about 10 percent who had defecation less than three times a week or had difficulty defecation had different health effects. Abdominal pain or bleeding from the rectum in cases of hemorrhoids causing ulcers in the colon or around the anus. Constipation can also be a symptom of a serious illness, such as colon cancer. It can make you depressed, and socioeconomic consequences may cause the patient to be absent or unable to work fully.  Objective: This study aimed to compare Court-type Traditional Thai massage with the used Cassia alata drug to treat chronic constipation. Methods: This study was a Randomized Controlled Trial, randomized 2-group trial, 30 patients were randomly allocated to use Court-type Traditional Thai massage and to use Cassia alata drug (15 patients/group). Patients in the massage group received 60 minutes sessions of Court-type Traditional Thai Massage 2 times a week and the Cassia alata drug used group received 1 sachet of drug dissolve warm water 7 days in a row (before bedtime). Functional constipation was measured before (pre-test) and after (post-test) 7 days compared between 2 groups by the constipation assessment tools, adverse reaction assessment form, and satisfaction assessment form.  Results: A study showed the massage group differed significantly from the drug group (P < 0.05). However, the adverse reaction assessment indicated no symptoms after massage while the drug user group had symptoms; of dizziness, nausea, and stomach discomfort after using the Cassia alata drug.   Conclusion: Court-type Traditional Thai Massage and Using Cassia alata drug was effective in treating functional constipation. However, massage therapy has no symptoms, and stomach comfort after treatment satisfies patients.
      PubDate: 2022-07-21
  • C10. A Systematic Review of Randomized Controlled Trial on Efficacy of
           Centella asiatica for Wound Healing

    • Authors: Parichart Hongsing, Kiattiya Areesuk, Natcha Atsalikon, Rutchaneekorn Pitiwattanakulchai, Chin Jai Wei
      Pages: 109 - 115
      Abstract: Introduction: The delay of wound healing leads to the risk of infection, chronic wound and other complications. Proper treatments for wound care will speed up the healing process and reduce scar formation. Centella asiatica is the famous medicinal plant among herbal skin care for healing both normal and chronic wounds with less adverse effects. Objective: This systematic review was performed to evaluate the wound healing properties of C. asiatica in clinical trials. Methods: A pre-registered systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search strategy and three electronic databases including PubMed, ScienceDirect and Google Scholar were used in this study. We had intended to perform a meta-analysis, but this was not possible due to variation in study design and reporting. The search strategy identified 1,410 articles through selected databases and 5 clinical trials met the inclusion criteria for quantitative synthesis. The quality assessment for risk of bias of the selected studies was evaluated by Cochrane risk of bias tool. The inclusion criteria were randomized controlled trials. We included participants with wounds regardless of age, gender, and ethnicity. The different types of wound are burn wound, diabetic foot ulcer, hypertrophic scar, split-thickness skin graft, and post laser resurfacing.  Results: The favorable effect of C. asiatica was observed with a quicker wound healing, possibly due to the synthesis of collagen type 1, 2, and 3, stimulation of fibronectin, and remodeling of the extracellular matrix. Furthermore, C. asiatica has a beneficial effect on anti-inflammation and increases tensile strength, accelerating the formation of epithelium and keratin. Conclusion: C. asiatica may have beneficial effects on wound healing; however, more clinical trials are needed in order to perform a meta-analysis to ensure the wound healing effects of the plant in different parameters.
      PubDate: 2022-07-21
  • C12. Research on Operation Method of Tuina Treatment of Constipation in
           Children Based on Data Mining Technology

    • Authors: Yuanwang Wang, Qifu Li , Ruilu Liu , Xiyu Wang , Exian Shan , Xinghe Zhang , Piyapach Thongprew, Xiantao Tai
      Pages: 123 - 130
      Abstract: Objective: To explore the Tuina manipulation (manipulation and acupoints) for treating pediatric constipation.
      Methods: Randomized controlled clinical studies (RCTs) on treating pediatric constipation by Traditional Chinese Medicine (TCM) Tuina were searched from the self-established database of PubMed, Web of Science, Cochrane Library, CNQI, VIP, and Wanfang database to December 2020. SATI, UCINET, and other data mining software were used to analyze the frequency statistics, visualization centrality and support degree of relevant operation methods (manipulation + acupoint) of TCM Tuina treatment for pediatric constipation, and SPSS 26.0 were used for cluster analysis.
      Results: A total of 874 pieces of literature were retrieved, and 133 RCTs literature were included after screening. Data shows 101 undifferentiated constipation prescriptions and 94 differentiated constipation prescriptions (including 48 excessive constipation and 46 deficient constipation). The results show undifferentiated constipation with abdominal rubbing manipulation (frequency 70, support 69.3%), pushing down Qijiegu manipulation (frequency 69, support 68.3%), clearing the Large Intestine manipulation (frequency 69, support 68.3%) has the highest centrality, which is a commonly used in combination. For excessive constipation, Clearing the Large Intestine manipulation (frequency 40, support 83.3%), pushing down Qijiegu manipulation (frequency 40, support 83.3%), abdominal rubbing manipulation (frequency 38, support 79.2%), Tuiliufu manipulation (frequency 35, support 72.9%) and the centrality is the highest, which is a commonly used in combination. For deficient constipation, strengthening spleen meridian (frequency 40, support 87.0%), spine pinching manipulation (frequency 37, support 80.4%), pushing Sanguan manipulation (frequency 32, support 69.6%) with the highest centrality, which is a commonly used in combination.
      Conclusion: The main idea of pediatric Tuina treatment of constipation is the dredging method. They are usually treated by rubbing the abdomen, pushing down Qijiegu, and clearing the Large Intestine manipulation. Tuisanguan and clear away heat and toxic material manipulations are frequently used to treat excessive constipation. For deficient constipation, strengthening spleen meridian, spine pinching, and Tuisanguan manipulations are frequently used to replenish Qi, strengthen the spleen and relieve constipation.
      PubDate: 2022-07-21
  • C13. Effects of circRNA in Notch Pathway on Differentiation and Maturation
           of Oligodendrocyte Progenitor Cells in Cerebral Palsy

    • Authors: Yuanwang Wang, Shouyao Zhang , Liuying Yang , Tianlei Gao , Xinghe Zhang , Pawat Thanavachirasin, Xiantao Tai
      Pages: 131 - 137
      Abstract: CircRNAs are ubiquitous non-coding RNAs, which are richly expressed in brain tissues and participate in the development and signaling of the nervous system and regulate complex functions and various neural activities of the brain. The Notch pathways can regulate multiple processes of cell morphology by regulating cell damage and apoptosis, inflammation, nerve repair and angiogenesis, and other processes involved in the occurrence and development of diseases. The Notch pathway critically regulates the differentiation and maturation of oligodendrocyte progenitor cells (OPCs), and the abnormal expression of circRNA can regulate the differentiation and maturation of OPCs through many pathways, including the Notch pathway, thus participating in the occurrence and development of cerebral palsy. This paper systematically reviewed the effects of circRNA on the differentiation and maturation of OPCs in cerebral palsy by regulating the Notch pathway to provide new ideas for the diagnosis, treatment, and research of cerebral palsy.
      PubDate: 2022-07-21
  • C14. Clinical Observation of Magui Wenbi Granules in the Treatment of
           Rheumatoid Arthritis and Its Effect on IL-23 / IL-17 Axis

    • Authors: Jia Yu, Yue Wang , Wachiraporn Padungkiettiwong, Xiangdong Cao
      Pages: 138 - 142
      Abstract: Introduction: Maguiwenbi granules are modified from Professor Wang Lvqiu's Xinbitongling granules used to treat cold-damp arthralgia syndrome in active RA and achieved an excellent curative effect. Previous studies have found that Xinbitongling can inhibit the expression of RANKL and IL-17 in the serum of CIA rats and alleviate the bone destruction of RA.  Objective: To observe the clinical efficacy of Magui Wenbi Granules in treating active rheumatoid arthritis (cold-dampness syndrome).  Methods: 60 patients were collected according to the NAPA standard and randomly divided into a control group and a treatment group with 30 cases each. The control group received conventional treatment, and the treatment group was added with Maguiwenbi granules. The joint treatment period was 12 weeks. Record the number of joint tenderness, joint swelling, DAS28, ESR, CRP, RF, TCM syndrome score before and after treatment, serum IL-23 and IL-17A levels, and use TCM syndrome efficacy evaluation standard and ACR20/50/70 standard to evaluate Perform overall clinical efficacy. Results: 59 patients, 1 excluded, 29 in the treatment group, and 30 in the control group. (1) The treatment group was significantly better than the control group in reducing the number of joint tenderness, swollen joints, DAS28, ESR, and TCM syndrome scores (P<0.01), and better than the control group in reducing IL-17A (P<0.05). However, there was no statistical difference between the two groups after treatment; (2) The total effective rate of TCM syndromes in the treatment group was 96.6%, and in the control group was 70.0%; the ACR20 and ACR50 of the treatment group were 96.6% and 24.1%, respectively, the ACR20 and ACR50 of the control group were 73.3% and 20.0%. Conclusion: Maguiwenbi Granules combined with conventional regimens have a definite clinical effect in the treatment of RA. It can significantly relieve the patient's clinical symptoms, reduce disease activity, increase clinical remission rate, and reduce IL-23 and IL-17A levels. It may inhibit IL-23/IL-17 inflammation axis. 
      PubDate: 2022-07-21
  • C16. Correlation between the 2- and 6- minute Walk Test in Healthy
           Children Aged 7-10 Years

    • Authors: Wilawan Chaiut, Sauwaluk Dacha, Ratana Sapbamrer, Rungnapa Malasao
      Pages: 147 - 151
      Abstract: Introduction: The 2- and 6-minute walk tests are used to assess walking ability, but the 2-minute walk test is not commonly known.   Objective: The purpose of the research was to investigate the correlation between the 2- and 6-minute walk tests in healthy children. Methods: A Cross-sectional study was carried out on healthy children whose age ranged from 7 to 10 in the first through third grades of primary schools in Chiang Mai province, Northern Thailand. Each participant also completed a 2- and 6-minute walk test on two separate test days by a week. Pearsons’ correlation coefficient (r) was calculated for the relationship between 2- and 6-minute walk test.  Results: In 2- and 6-minute walk tests, the mean walking distance was 203.6 meter from the 2-minute walk test and 559.79 meter form 6-minute walk test. A significant positive correlation was found between 2- and 6-minute walk tests, r =0.99, p = 0.001 of all participants.  Conclusion: These data suggest that the 2- and 6-minute walk tests in healthy children have fairly strong positive correlation. Our findings support the 2-minute walk test is a suitable alternative timed walking test for functional capacity testing in children.
      PubDate: 2022-07-21
  • C17. A Pilot Study of Chemical Composition and Major Compounds of
           Conservation Plant: A Case Study of Ma-Kwan from Doi Phu Kha, Nan Province

    • Authors: Nawatpong Chairat, Jantrararuk Tovaranonte
      Pages: 152 - 155
      Abstract: Introduction: The plant genetic conservation project under the royal initiative of Her Royal Highness Princess Maha Chakri Sirindhorn in response to the royal initiative by Mae Fah Luang University Botanical Garden has been a continuous survey and study on the utilization of indigenous plants. The results found that 391 types of Lua people and residents of Doi Phu Kha, Nan Province, categorized as food plants, medicines, housing, equipment and utensils. plants used in ceremonies and found an important spice is Ma-kwan (Zanthoxylum limonella).  Objective: The aim of this pilot to study the chemical composition of conservation plant and create a database of chemical composition of Ma-kwan that found in Doi Phu Kha, Nan Province. Methods: The fresh Ma-kwan were dried, pericarps and seeds were separated and coarsely grinded then the essential oils were collected by water distillation method. The essential oils from pericarp and seed’s part were analyzed for their chemical composition using Gas Chromatography-Mass Spectrometry (GC-MS).  Results: 35 compounds were found in essential oil; Piperitenol and p-Cymene were the most major compounds from pericarp and seed respectively. Moreover, essential oils obtained from the pericarp and seed have 16 identical compounds.  Conclusion: From the results of this study, the quantity and chemical composition of the essential oils from the fresh fruits will be recorded for comparison with fresh or dried fruits from different sources. They also know the major compounds found in the essential oils of fresh Ma-kwan found in Doi Phu Kha, Nan Province.
      PubDate: 2022-07-21
  • C18. Correlation between Perceived Severity of COVID-19 and
           Self-Protective Behavior during COVID-19 Pandemic in Chiang Rai Smokers

    • Authors: Supannikar Yingyongsaksri, Kantheera Jueaprasert, Jarukorn Thiboonmee, Patamawadee Chuaisri
      Pages: 156 - 162
      Abstract: Introduction: The COVID-19 disease affects among economy, society, and health in population. Smoking could increase chance of contracting COVID-19 and increase the severity level of COVID-19 symptom. No study about the impact of COVID-19, perceived severity of COVID-19 and smoking behavior in smoking population during COVID-19 pandemic in Chiang Rai.  Objective: There are three aims of this study which are to study smoking behavior, to study impact of the Covid-19 pandemic situation in Chiang Rai smokers and to study the correlation between perceived severity of COVID-19 and self-protection behavior during the COVID-19 pandemic in Chiang Rai smokers. Methods: The smokers have smoke at least 3 years, aged 18-60 years old and stayed in Chiang Rai were recruited in this study. A self-administered anonymous questionnaire was used to collect information via google form program. The questionnaires comprising 5 parts consisted of sociodemographic data, smoking behavior, impact of smoker on the covid-19 situation, perceived severity of covid-19 and protective behavior from covid-19.  Results: 215 smokes were recruited in this study. The most participants are 200 (93.0%) males, mean aged 33.03 (±12.38) years old. Mean duration of smoking is 15.11 (±11.98). Smoking behavior, they usually buy cigarettes from retail stores, 1 time a week, each time bought a pack of cigarettes, an average cost of 61-80 bath a time and average monthly cost of 101-500 baht. COVID-19 impact to income and expense of smokers. The protection yourself by wearing a mask, wash your hands with soap or alcohol gel and keeping distance in Chiang Rai did not affect the smoking behavior and the purchase of cigarettes among the smoking population in Chiang Rai. The correlation between perceived severity of COVID-19 and self-protective behavior from COVID-19 is 0.166 (p-value = 0.015).  Conclusion: There is not impact of the COVID-19 pandemic on smoking and the vigilant measures against the spread of covid-19 excepted economy. Poor correlation between perceived severity of COVID-19 and self-protective behavior from COVID-19.
      PubDate: 2022-07-21
  • C19. Effects of Extraction Solvents on Red Pigment, Phenolic Compounds and
           Antioxidant Capacity of Red Mold Rice Extracts

    • Authors: Kanyaphat Apiwongsrichai, Punyawatt Pintathon, Phanuphong Chaiwut, Sarita Sangthong
      Pages: 163 - 170
      Abstract: Introduction: Red mold rice is the rice cultivated by Monascus species that has long been used as natural color in traditional foods. It contains various bioactive compounds and has high potential biological activities of such antioxidant, antimicrobial and anticancer activities. It could be interesting for extraction of bioactive compounds using various solvents. Objective: This research was aimed to study effects of solvents on red pigment, phenolic compounds, and antioxidant capacity of red mold rice extracts.  Methods: Red mold rice was prepared by cultivating Monascus purpureus (M. Purpureus) under solid state fermentation method. The red mold rice was extracted with different 6 different solvents, i.e., DI water, 50% ethanol, 95% ethanol, 50% acetone, acetone, and ethyl acetate. Red pigment intensity was determined by colorimetric measurement. The total phenolic, and flavonoid contents were determined by Folin-Ciocalteu, and aluminum chloride colorimetric method, respectively. The antioxidant capacity of extracts was evaluated using DPPH and FRAP. Results: The result revealed that solvent types had significant effect on red pigment and phenolic compounds extractions, as well as antioxidant capacity of red mold rice extracts (p<0.05). The red mold rice extracted by ethyl acetate had the highest pigment intensity of 6,526.67 ± 100.66 unit/g extracts. Moreover, the highest total phenolic (78.13 ± 1.92 mg GAE/g extract) and flavonoid contents (97.10 ± 0.85 mg QE/g extract) was achieved by ethyl acetate while the lowest values were gained in the presence of water. The potential antioxidant activities expressed in terms of IC50 and FRAP value were reached to 12.63 ± 1.01 µg/mL, and 180.77 ± 7.70 mg TEAC/g extract, respectively, in the presence of ethyl acetate.  Conclusion: The properties of red mold extracts were strongly influenced by the type of solvent. Among of solvent tested, ethyl acetate was considered the potential solvent providing the highest red pigment, phenolic compounds, and antioxidant capacity. There are strong correlations among red pigment, phenolic compounds, and antioxidant capacity of red mold rice extracts. 
      PubDate: 2022-07-23
  • C21. Metadata and the Fatty Acids Content in Thai Shrimp Paste

    • Authors: Nichaphat Wisetchonlathan, Muthita Pitaktrairat, Chompunuch Glinwong
      Pages: 179 - 183
      Abstract: Introduction: The nutritional value of shrimp paste depends on the manufacturing process, such as the concentration of salt in the raw materials and the species of krill or small shrimp. In theory, different krill sources should have different bacterial species in communities. These are a major cause of the different chemical and physical properties of shrimp paste, especially the nutritional properties. This study focuses on microbial communities using the metagenome technique and the fatty acids content in the shrimp paste. Objective: The metagenomic profiles of the bacteria and analysis of fat content in Thai shrimp paste. Methods: Seven samples of fermented shrimp paste were obtained from various local markets and fishing villages and were analyzed for the fat content using an in-house method based on AOAC (2016). For analysis of the 16S rDNA metagenomic bacterial profile using Illumina sequencing. Results: KK3 sample has the highest level of Saturated fatty acid and unsaturated fatty acid (Omega 3, Omega 6, Omega 9). A total of seven metagenomic samples were sequenced that report the dominant bacteria were Bacillus, Lactobacillus, Staphylococcus, and Vibrio. Conclusion: This study can be the baseline information applied to develop the product of local or small enterprises.
      PubDate: 2022-07-21
  • C23. Factors Affecting to Breast Cancer Screening for Breast
           Self-examination among Women in Phitsanuloke Province

    • Authors: Amornsak Poum
      Pages: 191 - 196
      Abstract: Introduction: Breast cancer is majority problems for women worldwide, especially in Thailand had incidence rate of breast cancer increasingly. Breast cancer screening can found early new patient. Objective: Research aimed to study factors affecting to breast cancer screening for breast self-examination among women in Phitsanuloke Province, Thailand. Methods: Cross-sectional study was carried out 16,202 women aged 35-60 years which be registered in Phitsanuloke Province, in fiscal year 2020, and sample size calculating used Daniel formula for 210 cases, systematic random sampling was determine. Data collected by questionnaires composed of 4 parts including, characteristics, knowledge, health perception, breast cancer screening. In addition to check questionnaire standardization, validity was checked by 3 experts and try out testing reliability about 0.86. Data analyzed using statistical as Pearson product moment correlation coefficient and Stepwise multiple regression analysis. Results: Knowledge factors including knowledge of breast cancer, knowledge of breast cancer screening had mean score with high level ( x=2.18, S.D.=0.792), health perception including risk perceive, severe perceive, benefit perceive, problem perceive and confidence of breast self-examination had mean score with moderate level (x=2.46, S.D.=0.49). Association analyzed found that knowledge of breast cancer, health perception was associated with breast cancer screening for breast self-examination among women with statistic significant (r=0.208, P=.002, r=0.174, P=.012, respectively). Prediction model analyzed reported five selected factors including; confidence of breast self-examination (P<.001), take information from village health volunteers (P<.001), take information from partner/family member (P=.002), no alcohol drinking (P=.001), benefit perceive (P=.006), respectively, overall selected factors accounted for 25.9% (R2 =0.259) of the variance breast cancer screening.       Conclusion: We should disseminate women’ knowledge about initial symptoms of breast cancer, breast self-examination practice. Ministry of Public Health should provide the fundamental guideline for breast self-examination to health care providers at primary health care center to serve as a guideline for women.
      PubDate: 2022-07-21
  • C24. Effect of Thai herbal recipes on the immune system in
           streptozotocin-induced diabetic retired breeder mice

    • Authors: Supaporn Intatham, Parirat Khonsung, Phraepakaporn Kunnaja, Natthakarn Chiranthanut, Mingkwan Na Takuathung, Sunee Chansakaow, Seewaboon Sireeratawong Sireeratawong
      Pages: 197 - 205
      Abstract: Introduction: The deterioration of the immune system occurs with increasing age. Additionally, impaired insulin secretion and decreased insulin sensitivity are associated with aging. Type 2 diabetes mellitus is related to immune dysfunction that causes the elderly with diabetes to have a higher risk of infection. Herbal-based treatments are one of the therapeutic strategies for reducing blood glucose and also rejuvenating the immune system to improve the quality of life of the elderly. Objective: To investigate the immunomodulatory effect of two Thai herbal recipes in streptozotocin (STZ)-induced diabetic aging mouse model. Recipe 1 consisted of M. cochinchinensis, C. ternatea, and G. inodorum (1:1:1). Recipe 2 substituted C. zeylanicum for G. inodorum. Methods: Thirty-week-old male mice with diabetes induced by STZ were orally administered with Thai herbal recipes at the doses of 250, 500, and 1,000 mg/kg for 28 days. Blood glucose monitoring was performed on days 7, 14, 21, and 28. After 28 days, mice were sacrificed, spleen and thymus were weighed. The peripheral white blood cell count and differential were measured. Results: Treatment with both herbal recipes lowered blood sugar levels, however, the body weight loss could not improve in diabetic aging mice. Relative thymus weight seemed to increase in diabetic aging mice treated with a low dose of herbal recipe 1 and a high dose of herbal recipe 2. Additionally, diabetic aging mice treated with a low dose of herbal recipe 1 significantly increased relative spleen weight, whereas treatment with herbal recipe 2 at low and middle doses tended to decrease relative spleen weight. Treatment with both herbal recipes caused the diabetic aging mice to have a lower peripheral monocyte count. Nonetheless, treatment with a high dose of herbal recipe 1 significantly increased peripheral white blood cell (WBC), lymphocyte, and basophil counts. Conclusion: This study demonstrated the immunomodulatory and hypoglycemic effects of two Thai herbal recipes in diabetic aging mice. Interestingly, Thai herbal recipe 1 tended to be able to boost the immune system.
      PubDate: 2022-07-21
  • C25. Molecular Characterization of the Full-length Bipartite Begomovirus
           Causing Pepper Yellow Leaf Curl Disease, a Common Cause of Crop Damage in
           Northeast and Central Thailand

    • Authors: Amisa Laprom, Somrudee Nilthong, Srihunsa Malichan, Ekachai Chukeatirote
      Pages: 206 - 211
      Abstract: Introduction: The incidence of the yellow leaf curl disease of pepper is an important and serious threat for the production of pepper in Thailand. The disease is caused by whitefly-transmitted begomoviruses which can lead to severe economic losses of the crop. Objective: To determine and describe the complete sequences of begomovirus important species isolated from field infected pepper plants Methods: In this study, six diseased samples of the Capsicum anuum plants (showing yellow mosaic and leaf curling symptom) were collected from outbreak areas during a survey in 2016 – 2019 and used to extract total DNA. The full-length viral genomes were amplified by rolling circle amplification technology (RCA), cloned and sequenced bi-directionally. The generated sequences were then assembled and characterized including their phylogenetic relationships with other selected begomoviruses. Results: The sequences of the DNA-A genome from all six isolates showed the highest identity (97%) with the isolates of Pepper yellow leaf curl Thailand virus (PepYLCTHV). For the DNA-B component, it showed the closest cluster with those of PepYLCTHV (90% similarity). Conclusion: Based on the literature review and current evidence, this is the report confirming the presence of the PepYLCTHV bipartite begomovirus from Thailand.
      PubDate: 2022-07-21
  • C26. Therapy of strengthening spleen and Nourishing Kidney Massage in the
           Treatment of Global Developmental Delay

    • Authors: Shihui Zheng , Qingbo Wei , Xiaolin Fan , Yunchuan Wu
      Pages: 212 - 216
      Abstract: Objective: To investigate the clinical research plan of the therapy of strengthening spleen and nourishing kidney massage in the treatment of children with global developmental delay (GDD). Methods: A total of 60 children with GDD were randomly divided into the treatment group and the control group, 30 children of each group. Both groups of children accepted routine rehabilitation and the children were treated with Strengthening Spleen and Nourishing Kidney Massage in the treatment group plus the above treatment. The total course of two groups was 12 weeks. Before and after the treatment, children in both groups were evaluated with the Gesell Development Scale (GDS), Gross Motor Function Measure-88 (GMFM-88) and Infant-Junior Middle School Students Social life Abilities Scale (S-M scale). And the safety of the treatment was evaluated.  Conclusion: Pediatric Massage, as a non-pharmaceutical therapy, provides a new idea for the treatment of GDD.
      PubDate: 2022-07-21
  • C27. Study on the mechanism of exercise therapy in promoting neural stem
           cell mobilization after stroke

    • Authors: Simei Zhang, Yaju Jin, Xichen Yang, Sutthikiat Udommethaporn
      Pages: 217 - 220
      Abstract: Introduction: Stroke has become the third leading cause of death in humans, most of which are ischemic strokes. Exercise therapy is currently very popular and loved by most people. Studies have found that exercise training can promote neurogenesis, angiogenesis, synaptic plasticity, and neural stem cell proliferation and differentiation after cerebral ischemia. The Wnt/β-catenin signaling pathway regulates cell cycle and neurogenesis.  Objective: To observe the mobilization of endogenous neural stem cells by exercise therapy in rats with cerebral ischemia and its mechanism. Methods: Thirty SPF adult SD rats were selected, 8 rats were randomly selected as the sham operation group (sham), and the remaining rats were constructed as a middle cerebral artery occlusion (MCAO) model, and then the successfully modeled rats were randomly divided into the model group (MCAO) and exercise group (RUN), exercise group was given exercise treatment 24 hours after MCAO operation, once a day for 9 consecutive days, and model group and sham operation group were not treated. The neurological deficits of the rats were detected by behavior, the volume of cerebral infarction was detected by TTC staining, and the expressions of DCX and Wnt/β-catenin pathway-related proteins wnt3a and β-catenin in the infarcted cortex were detected by western blot.  Results: Compared with the sham operation group, the mNSS score of the model group was significantly higher (P<0.001), and compared with the model group, the mNSS score of the exercise group was lower (P<0.001). The Fault score was lower (P<0.001), and compared with the model group, the Foot-Fault score of the exercise group was higher (P<0.01); TTC staining showed that the cerebral infarction volume in the sham operation group was 0. The volume of cerebral infarction in the group increased significantly (P<0.001). Compared with the model group, the volume of cerebral infarction in the exercise group was reduced, but the difference was not statistically significant. Western blot showed that compared with the sham operation group, the protein expressions of wnt3a(P<0.01)and β-catenin(P<0.05) in the model group were lower, and compared with the model group, the protein expressions of DCX (P<0.05) and wnt3a (P<0.01) in the exercise group were higher.   Conclusion: Exercise therapy may promote the mobilization of endogenous neural stem cells in rats with cerebral ischemia by activating wnt/β-catenin.
      PubDate: 2022-07-21
  • C28. Comprehensive therapy based on pediatric Tuina in the treatment of
           Idiopathic Thrombocytopenic Purpura: A case report

    • Authors: Shouyao Zhang, Lin Gao , Siraprapa Veerapattananon, Xiantao Tai
      Pages: 221 - 224
      Abstract: Introduction: Idiopathic thrombocytopenic purpura (ITP) is characterized by extensive skin, mucosal or visceral bleeding, and the platelet count is less than 100×109/L. The etiology of ITP is unclear, the pathogenesis is complex and diverse, and there is no specific drug. Tuina and moxibustion are traditional external treatments of traditional Chinese medicine, which have the advantages of safety, effectiveness, and no adverse reactions. This paper reports a clinical case of ITP treated with TCM comprehensive therapy based on pediatric Tuina with satisfactory curative effect.  Objective: To observe the clinical efficacy of pediatric Tuina in the treatment of patients with ITP and to explore the feasibility of Tuina in the treatment of ITP. Case description: Sex, 8 years old, seeing a doctor on November 25, 2021. Two months ago, the patient suffered from subcutaneous hemorrhage in both lower limbs due to unknown causes, and the platelet count was as low as 30× 109/L. he was diagnosed with ITP in another hospital, then received oral prednisone acetate treatment, 5mg every time, 3 times a day, after meals, treated with traditional Chinese medicine at the same time. After 2 months of treatment, subcutaneous bleeding disappeared, and platelet count increased, accompanied by obesity, dizziness, joint pain, facial acne, and other adverse reactions. With Tuina treatment, once a day, 20 minutes per time, moxibustion once a day, 20 minutes per time, and taking Prednisone Acetate, the platelet count, body weight, and adverse reactions were gradually decreased. The treatment lasted for 12 weeks and was followed up for 1 month.  Results: Subcutaneous hemorrhage disappeared, dizziness and joint pain disappeared, weight loss, facial acne cured, bright and shiny skin, good mental state, platelet count fluctuated at about 80× 109/L, liver and kidney function examination were normal. The patients were followed up for 1 month without discomfort and could return to normal life and study. Conclusion: The report of this case shows that under the guidance of the basic theory of traditional Chinese medicine, the comprehensive therapy of pediatric Tuina combined with moxibustion can improve the clinical symptoms and quality of life of patients with ITP.
      PubDate: 2022-07-21
  • C29. Effects of Electroacupuncture on FUNdC1-LC3 Signaling Pathway in Rats
           Cerebral Ischemia-reperfusion Injury

    • Authors: Li Zhou, Yongdan Cun , Chengcai Zhang, Kittiphum Ruangravevat, Pengyue Zhang
      Pages: 225 - 228
      Abstract: Objective: To observe the effect of electrotherapy on the FundC1-LC3 signaling pathway in cerebral ischemia reperfusion injury (CIRI) rats and to explore the mechanism of its intervention on CIRI from the perspective of mitochondrial autophagy.  Methods: 24 SD rats were randomly divided into sham operation group, model group and electroacupuncture group.  In the electroacupuncture group, electroacupuncture treatment was started 24h after modeling for 30min and lasted for 3 days.  The neurological function of the rats was scored before sampling.  TTC staining was used to calculate the volume of cerebral ischemia infarction in rats.  Western blot was used to detect LC3B and FUNDC1 protein expression in cortical region.    Results: Compared with the sham operation group, the neurological function score of the model group was significantly higher, and the neurological function deficit was serious.  LC3B protein expression was increased in cortex, and the differences were statistically significant.  Compared with the model group, the neurological function score of the electroacupuncture group was significantly lower, and the neurological function defect was improved.  LC3B and FUNDC1 protein expressions were increased in cortical area, and the differences were statistically significant.    Conclusion: Electroacupuncture may promote the FUNDC1-LC3 signaling pathway to up-regulate mitochondrial autophagy and alleviate neurological impairment in rats, thus playing a neuroprotective role.  
      PubDate: 2022-07-21
  • C31. Traditional Chinese Medicine in Treating Depression

    • Authors: Jia Wei Chin, Siraprapa Veerapattananon, Kittiphum Ruangravevat, Raksuda Taniguchi
      Pages: 234 - 236
      Abstract: Depression is a mental health disease that causes patients to be in a negative emotional situation. It is a psychosomatic disease that is difficult to recover from and has a high recrudescence rate. Much research and clinical results showed that Traditional Chinese Medicine (TCM) is effective in depression and can reduce the symptoms. A depression patient with depression came for acupuncture treatment. After four acupuncture treatments, the emotion turned more positive, and symptoms such as insomnia, poor appetite, body pain, etc., had reduced. These cases showed that TCM is an effective and alternative option for depression.
      PubDate: 2022-07-21
  • D01. Data Analysis of Acupoint Selection in Acupuncture Treatment for
           Post-Stroke Depression Based on Traditional Chinese Medicine Inheritance
           Support System (TCMISS)

    • Authors: Pornfah Ananpaisarn, Titi Phanjaroen
      Pages: 237 - 241
      Abstract: Introduction: Post-Stroke Depression (PSD) is the one of the most common clinical complications in stroke patients. There are currently many methods of treatment for this disease, for Traditional Chinese Medicine acupuncture will be used mainly because it is safe, effective and few side effects.  Objective: To summarize the rule of acupoint selection in acupuncture treatment of post-stroke depression based on data mining of clinical literature papers by Traditional Chinese Medicine Inheritance Support System (TCMISS) to provide new insights in clinical therapy. Methods: The clinical research literature on acupuncture treatment of post-stroke depression was collected from the CNKI, Weipu and Wangfang Journal database between May 2012 to April 2022. The acupoint prescription was entered into the “Traditional Chinese Medicine Inheritance Support System (V2.5) software” and were analyzed for frequency, repetitive and core combination of prescribed acupoints.   Results: 85 articles, 85 acupoint prescriptions and 79 acupuncture points were included into the study. The acupoints with highest frequency in overall usage in descending order are Baihui (DU20), Taichong (LR3), Neiguan (PC6), Shenmen (HT7) and Sishenchong (EX-HN1). The hight-frequency acupoints combinations are listed as follows: Baihui (DU20) and Neiguan (PC6), Baihui (DU20) and Taichong (LR3), Baihui (DU20) and Shenmen (HT7).  Conclusion: Data mining and analysis of acupoint selection in acupuncture treatment of post-stroke depression could provide a new idea and insight for further clinical treatment.
      PubDate: 2022-07-21
  • D02. Linalool Exerted a Neuroprotective Activity against
           Corticosterone-induced Apoptosis of PC12 cells

    • Authors: Somrudee Saiyudthong, Niphat Jirapongwattana, Yamaratee Jaisin, Punnee Nusuetrong
      Pages: 242 - 246
      Abstract: Introduction: Linalool is an active compound found in many essential oils having sedative, anxiolytic and analgesic properties. Therefore, these essential oils have been usually used in aromatherapy to reduce stress. However, the mechanism underlying anti-stress of linalool has not been investigated. Objective: To investigate the mechanism of neuroprotective action of linalool on corticosterone-induced neurotoxicity in PC12 cells. Methods: PC12 cells were treated with 650 μM of corticosterone in the absence or presence of linalool or fluoxetine for 24 hours. PC12 was treated with corticosterone 650 μM and difference concentration of linalool (100, 200, 300, 400, 500, 600 and 700 μM) for 24 hours. Methyl thiazolyl tetrazolium (MTT) assay and lactate dehydrogenase (LDH) detection were investigated to confirm the neuroprotective effect of linalool against cell damage caused by corticosterone. Then, the intracellular Ca2+ content was measured by fluorescent labeling. Results: Linalool 100 and 200 μM significantly increased cell viability compared with the group treated with corticosterone alone (p<0.05). Linalool 100, 200, 300 and 400 μM significantly (p<0.05) reduced LDH release. Linalool (100, 200, 300, 400, 500 and 600 μM) tend to revere the increased intracellular Ca2+produced by corticosterone. Conclusion: These findings indicated that linalool exerted a neuroprotective activity against corticosterone-induced neuronal apoptosis in PC12 cells. The mechanism underlying this action may be partly due to the attenuation of intracellular Ca2+ overloading under stress conditions. However, further studies need to investigate the precise cellular and molecular mechanisms underlying this neuroprotective activity of linalool.
      PubDate: 2022-07-21
  • D03. Anti-biofilm Potential of Boesenbergia rotunda L. Extract and Synergy

    • Authors: Phutthida Kongthitilerd, Griangsak Eumkeb, Yothin Teethaisong
      Pages: 247 - 251
      Abstract: Introduction:  A biofilm is extracellular substances produced by microorganisms to protect themselves from harmful agents, including antibiotics. Bacteria living in biofilms are known to have higher resistance to antimicrobial therapy and is one of the most important mechanisms of resistance to antibiotics. Hence, development of a novel anti-biofilm agent is of far-reaching importance.  Objective: To investigate the anti-biofilm effect of B. rotunda extract (BRE) and its synergism with cloxacillin (CLX) on biofilms of β-lactam-resistant Staphylococcus aureus.   Methods: B. rotunda extract was carried out by macerating with 99.9% ethanol. The extracts were subsequently dried using a rotary evaporator and lyophilized. The anti-biofilm activity and synergistic effect of BRE were carried out by a crystal violet assay. Quantitation of biofilms were done by a spectrophotometer, while qualitative analysis of biofilm formation was observed under a light microscope.    Results: Following 24 h of treatment, the result from quantitative analysis of biofilm formation using a crystal violet assay revealed that BRE significantly eradicated biofilms of β-lactam-resistant S. aureus. Interestingly, the combination of BRE and CLX synergistically inhibited biofilm formation. In line with qualitative analysis of biofilm formation, bacteria treated with BRE and CLX, either alone or in combination, had explicitly lower biofilm than untreated control.  Conclusion: BRE potentially destroyed biofilms and had synergistic effect with CLX in eradication of biofilms of β-lactam-resistant S. aureus. These findings from the evidence that the combination of BRE and CLX could be a good candidate for further development as a novel agent for treatment of recalcitrant infection caused by β-lactam-resistant S. aureus.
      PubDate: 2022-07-21
  • D04. Psychological Effects of Nail Color

    • Authors: Narunan Wuttisin, Juthamart Thondee, Nattinan Srijatupornpong
      Pages: 252 - 257
      Abstract: Introduction: Nail polish is a cosmetic used to apply color for beautifying fingernails and toenails. Nail polish may be provided benefits as color therapy for balancing psychological problems.  Objective: The objective of this study was to find the benefit of colors from nail polish application based on the theory of color therapy. Methods: The participants were 200 female students at Mae Fah Luang University. They were divided into 2 groups; blinded and unblinded by their perception of color therapy. The participants applied their nails with different colors based on their emotions and determined the color effects after 1 week of application by answering the questionnaires.  Results: The results found that the main problems of participants were depression (13.00%), rough (12.50%), complicated (11.50%), and lack of confidence (10.50%), respectively. The score of the emotion of each participant was determined before and after nail polish application and found a significant decrease (p<0.05) in the emotion problem after the experiment. State-Trait Anxiety Inventory (STAI) and Beck Anxiety Inventory (BAI) were used to measure anxiety levels and found a significant decrease (p<0.05) in both scores after nail polish application. The positive psychological effects of nail color were found in both groups without any bias in the results. In addition, most of the participants were satisfied with their nail colors and half of them felt a change in their emotions after nail polish application.   Conclusion: Nail color applications help to improve the emotion and decrease the anxiety levels of participants.
      PubDate: 2022-07-21
  • D05. A comparative study for clinical efficacy and safety between a
           combination of fractional radiofrequency and microneedling with fractional
           radiofrequency alone in the treatment of striae distensae

    • Authors: Pattarapol Techasuwanna, Anon Paichitrojjana, Thep Chalermchai
      Pages: 258 - 263
      Abstract: Introduction: Striae distensae present with structural change of collagen bundles, elastolysis and cellular infiltration, that led to skin flattening, discoloration, and scarring. There is no standard treatment nowadays. Fractional radiofrequency (RF) is a radio transmission that generates thermal effect that promote wound healing effect and stimulate collagen and elastin production. Microneedling is an alternate modality that can also stimulate collagen production. Objective: This study aimed to compare the efficacy and the safety of a combined fractional radiofrequency and microneedling versus fractional radiofrequency alone for treating striae distensae. Methods: This was a prospective, randomized-controlled, assessor-blinded, intra-individual split-side comparative, experimental study. Inclusion criteria included all participants aged 18-50 years with Fitzpatrick’s skin type III and IV with bilateral sides of striae alba. All participants were randomly assigned to be treated with combined fractional RF and microneedling therapy on one side of the body or fractional RF alone in contralateral side for 3 sessions. The primary outcome was the Global Aesthetic Improvement Scale (GAIS). The secondary outcomes included the width and length of striaes, patient’s satisfaction’s score, and adverse events. Results: There were 22 participants with the mean (SD) of 29 (7.8) years and 90.9% were female (n=20). The GAIS, assessed by two blinded dermatologists was significantly better improved in the combination group than fractional RF alone group at 4, 8, and 12 weeks (p < 0.05). The striae width and length significantly decreased in both groups without significant differences. There was no difference in patient’s satisfaction score at week-12 visit between the 2 groups. Common adverse event included post-inflammatory hyperpigmentation (PIH) (36.4%) in the combination group and (27.3%) in fractional RF alone group without significant difference. Conclusion: A combination of fractional radiofrequency and microneedling had better clinical efficacy in term of GAIS than fractional radiofrequency alone in treating striae distensae. 
      PubDate: 2022-07-21
  • D06. The Protective Effects of Marine Microalgae Extract on Skin
           Cells-inducted Sun Ray

    • Authors: Thanchanok Muangman, Narin Chansawang, Intira Pathtubtim
      Pages: 264 - 270
      Abstract: Introduction: In the present study, two kinds of marine microalgae, Tisochrysis lutea (Coccolithophyceae) is a single microalga widely used as live food in aquaculture. Tetraspora gelatinosa (Tetrasporaceae) is spherical to elliptical cell, arranged two-by-two or four-by-four, with 2 pseudoflagella extending beyond the mucilage. They are able to produce high value chemicals which can be applied in feed and food, pharmaceutical, nutraceutical and cosmeceutical industries.   Objective: To determine effects of T.lutea and T. gelatinosa  extracts on skin cells functions. Methods: Dried microalgal biomass of microalgae were extract with ethanol. The biological activity of microalgae extracts was investigated on skin cells such as keratinocyte cells (HaCaT) and melanoma cells (B16F10). The protective effect against photo-inducted inflammation, oxidative stress and melanogenesis were investigated. Cytotoxicity of microalgae extracts were determined using WST-assay. Sun ray was treatment to HaCaT cells for inflammation and oxidative stress effect. and B16F10 cells was treated sun ray to inducing and melanin production.  Results: The content of the biochemical components in two marine microalgae showed total carbohydrate and protein content were the main component of T. gelatinosa.  The effect of T. lutea and T. gelatinosa were exhibited to suppressing cytokine secretion, melanin content, and ROS production on sun ray-induced skin cells. Moreover, T. gelatinosa was showed significant protective effect on ROS scavenging.  Conclusion: T. lutea and T. gelatinosa are marine microalgae that have benefit on skin cells to protect sun ray induce cell damage and skin pigmentation. The protection activity on keratinocyte cells including anti-inflammation via cytokine PGE2 suppressing and anti-oxidative by ROS scavenging from sun-ray stimulation. Therefore, both of marine microalgae may have the potential to use as an active ingredient in cosmetic or cosmeceutical products.
      PubDate: 2022-07-21
  • D07. Development of Problem Solving Skill by Project-Based Learning in
           Physical Therapy Students, Mae Fah Luang University

    • Authors: Haruthai Petviset, Sasima Pakulanon
      Pages: 271 - 274
      Abstract: Introduction: Project-based learning is a classroom approach that based on the problems or questions that allows student to work together on a project. The engagement of the student in the investigation of problems could help student to develop problem -solving skill which could be applied in physical therapy in sports course. Therefore, this study hypothesized that the use the project-based approach in physical therapy in sports course could improve problem-solving skill in physical therapy student. Objective: To evaluated the effect of project-based learning on problem-solving skill in physical therapy in sport course. Methods: Students worked on the athletes to identify the problem and then did the searching and concluded the all of the data for planning and constructed the project. The problem-solving skill will be evaluated on the first and final week. The satisfaction survey of this course was taken by the students after the project by the university system. Results: The problem-solving skill is significantly improved by project-based learning in physical therapy in sports course and the satisfaction after this course was in high satisfaction level.  Conclusion: The project-based learning in physical therapy in sports improved the problem-solving skill of the physical therapy students in this course.
      PubDate: 2022-07-21
  • D08. Ultrasonic Assisted Extraction Enhanced Total Phenolic and
           Antioxidant Activities from Aegle marmelos (L.) Corr. Extract

    • Authors: Sinee Siricoon, Phakamas Sombatmak, Wiriyaporn Sumsakul, Thongkorn Ploypetchara, Waraporn Sorndech, Siriporn Butseekhot, Chiramet Auranwiwat
      Pages: 275 - 278
      Abstract: Introduction: The ultrasonic assisted extraction (UAE) is a green technology to extract bioactive compounds from natural sources. The extraction process showed the high efficiency in part of activity and reducing time. Aegle marmelos (L.) Corr. or bael has been used as traditional medicine to dysentery, fever, diabetes, asthma, heart problems. There are various kinds of secondary metabolites have been reports and their pharmaceutical activities. Objective: To determine total phenolic content and antioxidant activities of two methods of extraction; maceration and ultrasonic assisted extraction. Methods: The powder of A. marmelos was extract by maceration and UAE using water and EtOH as solvents. The extract was investigated total phenolic content and antioxidant activity including DPPH and FRAP assays. Results: The ultrasonic assisted extraction of ethanolic extract at 15 minutes showed the highest values of total phenolic content at 79.75±0.05 mg GAE/g crude extract. Moreover, the antioxidant activity of extract using UAE at 30 minutes exhibited the most percent inhibition about 39.50% in DPPH assay whereas hot water extraction found the better antioxidant activity in FRAP assay with the value of 355.75 μM/g crude extract.  Conclusion: UAE method was high efficiency in the extraction especially in term of extraction time and bioactivity.
      PubDate: 2022-07-21
  • D09. A Cross-sectional Survey of Traditional Chinese Medicine Constitution
           in Thailand's Type 2 Diabetic Population

    • Authors: Sitthichock Vadphimai, Piyapach Thongprew, Wachiraporn Padungkiettiwong, Nakornsub Lawcharoen, Peeranan Pattanamongkol, Xiuge Wang
      Pages: 279 - 284
      Abstract: Introduction: This paper uses "Traditional Chinese Medicine Constitution Classification and Judgment Table" to conduct a cross-sectional survey and research the traditional Chinese Medicine constitution in Thailand's type 2 diabetic population. Objective: To examine the TCM constitution of patients with type 2 diabetes in Thailand. Methods: This study selected 424 Type 2 diabetes patients from January 2021 to July 2021 in Roi Et City, Thailand, Public Health Service Center, Traditional Chinese Medicine Outpatient Department, and Inpatient Department, Nakhon Ratchasima City, Thailand, Hua Laem Community, Don Thabuang Community, using "Traditional Chinese Medicine Constitution Classification and Judgment Table" for investigation, using Microsoft Excel to collect the general data and the distribution characteristics of TCM constitution, and SPSS 23 software for analysis. Results: Among 424 people with type 2 diabetes in Thailand, Female patients were 58.96%, and Male patients were 41.04%. The age distribution is at most between 46-and 55 years old. For general data, Patients with a high BMI were 55.42%. The most significant number of cases in the distribution of TCM constitution is "Yin deficiency constitution," 30.2%. The highest distribution of syndrome types was "Qi and Yin deficiency syndrome," 39.7%. The difference was statistically significant (P<0.05). Conclusion: "Yin deficiency constitution" and "Qi and Yin deficiency syndrome" is found the most in Thai type 2 diabetes patients. Gender, age, education level, diet, and BMI are the factors that affect the formation of the biased constitution in patients with type 2 diabetes.
      PubDate: 2022-07-21
  • D10. Antiglycation, α-glucosidase, and α-amylase Inhibitory Activity of
           Guava Leaf Hydrosol

    • Authors: Witayapan Nantitanon, Pimpailin Rodpradit, Natthawut Thitipramote
      Pages: 285 - 289
      Abstract: Introduction: Guava leaf oil (GLO) is one of the economic products obtained from the hydrodistillation process. It is widely used in the cosmetic, pharmaceutical, and nutraceutical industries. In this process, residual water (hydrosol) is generally drained out as effluent. There is no information available regarding this hydrosol's bioactivity for health.  Objective: This study aimed to evaluate the antiglycation and inhibitory activity of α-glucosidase and α-amylase enzymes which are related to diabetes mellitus. Methods: Hydrosol used in this study was obtained from the essential oil production of guava leaves using the hydrodistillation process. This process was performed at guava leaves to water ratio of 1:10 (w/v) at 100 oC for 2 hours. The obtained hydrosol was then freeze-dried to obtain the hydrosol powder. Phenolic content (TPC) of hydrosol powder was determined using both Folin–Ciocalteu’s reagent and HPLC methods. Inhibition of glycation, α-glucosidase, and α-amylase of hydrosol was also evaluated. Results: The hydrosol yielded 5.4±0.8 %w/w of fresh leaves. TPC of the hydrosol was 134.3±3.6 mg of gallic acid/ g of hydrosol powder. The Antiglycation (IC50) of the hydrosol was 9.6±1.3 µg/mL, which showed higher efficacy than aminoguanidine. Inhibition of the hydrosol (IC50) against α-glucosidase, and α-amylase was 413.3±10.7 and 596.6 ±4.6 µg/mL, respectively. Conclusion: Hydrosol byproduct obtained from essential oil distillation of guava leaves should be promising candidates for hypoglycemic functional product and antiaging ingredient.
      PubDate: 2022-07-21
  • D11. Research progress in the prevention and treatment of osteoporosis
           with exercise therapy

    • Authors: Dezhi Zhou, Mengxing Yin , Xiufang Li , Peeranan Pattanamongkol, Fu Jia
      Pages: 290 - 295
      Abstract: Osteoporosis is a systemic bone disease. Osteoporosis is a systemic bone disease characterized by reduced bone mass per unit volume, degeneration of bone microstructure, thinning of bone density, reduction of bone trabecular number, widening of bone marrow cavity, and reduced bone strength, which are easy to fracture. Exercise therapy can effectively improve the bone mineral density of patients with osteoporosis and significantly intervene in the risk of osteoporosis. In addition, compared with drug therapy, exercise therapy has the advantages of economy and no adverse reactions, which attracts more and more people's attention. However, at present, patients and the public generally lack the correct understanding of exercise therapy, coupled with the characteristics of exercise itself (exercise mode, exercise intensity) and the influence of the patient's own conditions, the efficacy of exercise therapy in the practical application process has not been fully highlighted. This paper summarizes the effect of exercise therapy on osteoporosis, hoping to provide help for the clinical application of exercise therapy in the prevention and treatment of osteoporosis.
      PubDate: 2022-07-21
  • D12. Discussion on the Application of Pharmacological Theory of
           Traditional Chinese Medicine in the Treatment of the Covid 19 Cases

    • Authors: Laksika Sakunkamjornkit, Sin Khee Ho
      Pages: 296 - 298
      Abstract: In clinical, there were limitations which the application of Traditional Chinese Medicine (TCM) using syndrome differentiation and treatment for novel epidemic disease. Meanwhile, modern scientific research gradually unravels the internal biochemical mechanism of the human body and analyzes the composition of Chinese herbs, and excavates and selects effective structures, and it has been confirmed that the combined application in treatment can expand the curative effect. Covid19 is a highly contagious modern epidemic disease, the only reliable way to diagnose patients is to fight against it by the human immune system. This article uses the combination of TCM pharmacology and immunology theory to give examples of diagnosis and treatment, to explore the feasibility of modern TCM pharmacology theory in clinical treatment and hope to develop another kind of thinking in the future.
      PubDate: 2022-07-21
  • D13. The Herbal Medicine of Vernonia cinerea. Tea Comparing the
           Effectiveness of Herbal Medicine with Placebo to Anti-cigarette Smoking.
           U-Thong Hospital Suphanburi, THAILAND

    • Authors: Chuleekorn Kwanchainon, Chaweewan Dongjorn
      Pages: 299 - 303
      Abstract: Introduction:Vernonia cinerea is a herb in ACANTHACEAE family, that is packed in the National list of essential Medicines ( NLEM ) and anti appetided food when before eat. Smoking is  cessation rates increased among those who received medications and counseling and recommendations, and research has been taken from Thai  healer to make  anti-smoking drugs. Objectives: The aim are  study to :1 To  trial test of  Herb  Vernonia cinerea . 2. Research  on  herb   placebo. 3.  study  to side effects herbal medicine . Methodology :  Using  are evaluated an interview form.  And statistical success program statistics,  This study  for two group the  experimental study of double bilnd . The results : The average number of smoking The average number of cigarettes smoked was 8 cigarettes per day after 10 days of attendance.  The number of cigarettes smoked 6-7 cigarettes per day after 15 days of participation in the trial group was statistically significantly reduced ( P < 0.05 ) because this study also impaired the control of variables.  Conclusion:  the study  this of Vernonia cinerea tea , This herb contain nitrates and nitride, It causes nausea and vomiting.  it  cause to   minimum  the cigarret   , so it was the result of making cigarette  to decreased pills, and sometime many  used to make anti-appetite medications. Thun  auther to having a  food  before eating will also cause you to lose weight  too.
      PubDate: 2022-07-21
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