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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
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Natural Volatiles & Essential Oils
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  This is an Open Access Journal Open Access journal
ISSN (Online) 2148-9637
Published by Badebio Biotechnology Ltd Homepage  [1 journal]
  • An Insight Into The Pharmacological Profile Of Hydroxy Cinnamic Acid, An
           Active Constituent Of Ferulic Acid

    • Authors: Tejesvi Mishra ; Chanchal Sharma , Karan Singh , Sanjeev Kumar Chauhan , K. Nagarajan , Vinay Kumar
      Pages: 1 - 19
      Abstract: Ferulic acid, a hydroxyl cinnamic acid derivative, belonging to the natural phenolic compound category is known for its anti-inflammatory actions. As inflammatory diseases are one of the major causes of raised chronic diseases in the human body that can be cured with the help of ferulic acid. The functional organs of the body that are more prone to pathogens due to invasive ingestions and changing lifestyles can also be treated with the help of ferulic acid. This biological native substance is active in protective measures of various acquired diseases. The anti-inflammatory effect of ferulic acid is due to the chemical structure similarity with curcumin which inhibits reactive oxygen species (ROS), inflammatory biomarkers including cytokines, inflammasomes, TNF-α, and C-reactive protein (CRP). Also, the presence of the hydroxyl cinnamic acid group within the ring helps in the suppression of free radicals during excessive free radicals’ formation. It’s anti-inflammatory and activity against oxidative stress make it a helpful and potential compound for the treatment of various neuro-inflammatory diseases such as Parkinson’s disease, Alzheimer’s disease, etc. In recent studies, it has also been found that the anti-inflammatory properties of ferulic acid can be utilized in cancer studies, immune disorders, and aging.
      PubDate: 2022-08-28
      Issue No: Vol. 9, No. 3 (2022)
       
  • Identifying And Predicting Climate Stress For Agricultural Practices In
           The North West Region Of Syria

    • Authors: Alzamil Teysir ; Alymany Ghada , Bibars Salah , Hussian Abdulrahman
      Pages: 20 - 32
      Abstract: Climate changes affect all sectors of life, especially the agricultural sector, where rising temperatures and drought have caused a decrease in many types of agricultural crops, which poses a threat to global food security. Here we examine potential changes in climate variables (precipitation and temperature) over the freed areas of northern Syria, with the aim of developing a new prediction system for multi-year agrometeorological risks (i.e. drought and extreme heat) over the freed areas of northern Syria. We first conducted interviews, highlighting that regional practitioners do adapt their practices depending on weather/climatic forecast, switching to crops that are more resilient to drought, or adapting their agricultural calendar, but that stressing the need for more reliable forecast of agrometeorological risks. Using ERA5 data between 1979 and 2021, we indeed found an increase in drought risks, which is strongly related to an increase in maximum temperature, enhancing evapotranspiration.  We thus test the benefit of neural network in providing reliable prediction for maximum temperature and drought indices.Preliminary results are promising with minimal errors in the mean, and in the variance of predicted data, as compared to the original data. Therefore, we implemented different sensors over the freed areas of northern Syria to monitor climate variations, and to set a live monitoring system, from which new and accurate prediction for climate stress will be provided on seasonal basis.
      PubDate: 2022-08-30
      Issue No: Vol. 9, No. 3 (2022)
       
  • Evaluation Of Sugarcane Clones Based On The Performance In Preliminary
           Yield Trials

    • Authors: Naeem Ahmad ; Muhammad Shahzad Afzal , Hafiz Basheer Ahmad , Abdul Khaliq , Mubashra Yasin , Salma Niaz , Mahmood ul Hassan , Imran Rasheed , Muhammad Younus , Humaira Kausar , Amina , Muhammad Rizwan Khursheed
      Pages: 33 - 42
      Abstract: Current study was conducted at Sugarcane Research Institute, Faisalabad during 2019-20.  Preliminary Yield Trials is an important stage of varietal development program comprising on 4th year of study. Current study was conducted to evaluate the performance of twenty six clones in comparison to two check varieties deploying randomized complete block design (RCBD) using three replications. All these clones were developed from fuzz imported from Srilanka as natural conditions are not conducive for flowering and hybridization of sugarcane in country. The data was subjected to principle component analysis based on five parameter (tillers per plant, no. of canes per hectare, yield (t/ha), sugar recovery (%) and single cane weight) and analysis of variance. The characters tillers per plant, no. of canes per hectare and single cane weight had positive association with yield per hectare. These character should be focused during selection process. The data was interpreted based on 66 percent information contained in PC-2. The linkage cluster analysis placed the clones into six major groups which were genetically different. The variation in cluster can be utilized in breeding program for further improvement. Based on superior performance, nine clones were selected and promoted to next selection stage named semifinal varietal trial for further evaluation.  A clone S-2016-SL-284 outclassed all the clones in term of performance of all parameters under study which will be bright future hope to be recommended a variety for commercial release in coming years. The clone was from the fuzz of local parents exchanged with Srilanka, so local germplasm should be given key importance while choosing the parents for crossing purpose in breeding program of sugarcane. Local hybridization program may serve the purpose of desired parents having suitability in adaptation in local climatic conditions.
      PubDate: 2022-09-01
      Issue No: Vol. 9, No. 3 (2022)
       
  • Quality By Design Approach For Development Of Amorphous Solid Dispersions
           Of Efavirenz By Melt-Quench Technique

    • Authors: Priyadarsini M ; Prameela Rani Avula
      Pages: 43 - 59
      Abstract: Melt-quench method is a novel and an evolving technique to develop amorphous solid dispersions (ASDs) of crystalline compounds to improve their solubility. Efavirenz is a crystalline compound and is practically insoluble in water so that it suffers dissolution limited bioavailability. The major objective of this work was to optimize carrier, plasticizer and cooling temperature as the independent factors used in melt-quench method for preparing Efavirenz ASDs (EASDs) to have maximum solubility and stability which were taken as the responses. Box-Behnken design (BBD) under response surface methodology was employed as the experimental design to develop EASDs. The prepared EASDs were characterized by differential scanning calorimetry (DSC) and X-ray diffraction (X-RD) analysis to investigate the physical state of EFV and the stability of the EASDs upon storage. Solubility was also checked for all the EASDs. The effect of the factors on the responses were analysed found to be significant by analysis of variance (ANOVA) at p < 0.05. The DSC and X-RD results indicated that EFV was successfully converted into amorphous form by the applied method. Further, DSC and solubility studies also inferred that slow cooling with high concentrations of the carrier and plasticizer provided maximum stability of these ASDs upon storage by reducing recrystallization. The graphical optimization was performed and inferred that the EASDs prepared at 50% w/w of Soluplus as the carrier, 15% w/w of Poloxamer 188 as the plasticizer with -1.92oC as the cooling temperature in melt-quench method provided EASDs with maximum solubility and stability.
      PubDate: 2022-09-01
      Issue No: Vol. 9, No. 3 (2022)
       
  • Study Of Self-Efficacy Feeling As Performance Estimators

    • Authors: Sepideh Ghotniana ; Elham Mozayankharazy , Isa Chalishgar , Zahra Ansari
      Pages: 60 - 64
      Abstract: Introduction: Present research investigates self-efficiency feeling behavior as performance estimators. Method: The research employs descriptive-correlation method. The statistical population includes all the130 male karate athletes who participated in the qualification matches for the adult national karate team of Iran. In this research, the sample is considered to be equal to the population comprising 130 athletes from which 120 questionnaires were received. Finally, to test the research’s hypotheses, Pearson Correlation and Univariate Regression Analysis were employed. Results: Results indicated the correlation between self-Efficacy feeling and performance (r = 0.953). Conclusion: The results indicated the variables self- Efficacy was able  to affect performance level in the participants and this effect was predictable.
      PubDate: 2022-09-14
      Issue No: Vol. 9, No. 3 (2022)
       
  • The Effect Of Biofertilizers And Different Drying Method On The Quality
           And Quantity Of Lemon Balm (Melissa Officinalis) Essential Oil

    • Authors: Abdollah Hatamzadeh ; Jalal Abbasian , Farsad Najafi , Ahmad Balandary
      Pages: 65 - 78
      Abstract: The aim of this study was to apply mycorrhiza and azotobacter biofertilizers to increase the yield and recognize the most proper method for drying Lemon Balm to conserve the quality and quantity of active ingredients. The transplants were treated with mycorrhiza and azotobacter before beding transferred to the main field. The drying process was carried out subjected to sun, shading, oven (35 and 55 oC), and microwave (Output power of 100, 300, 900 w), and the quality and quantity properties were measured. Variance analysis showed that Mycorrhiza and Azotobacter significantly affect the quantitative traits, including fresh weight and dry weight, plant height, leaf number per plant, 10 leaf area, and the essential oil percentage (P<0.05). Drying methods significantly affect the essential oil percentage, appearance, Geraniol, Neral, Citronella, Caryophyllene Oxide, Citronellal, Beta-Caryophyllene, Geranyl acetate, and Geraniol (P<0.01). Mycorrhiza increased the Lemon Balm’s essential oil percentage. Appearance, essential oil percentage, and the effective ingredients of the essential oil, such as Geranial (citral a), citronella, and caryophyllene oxide, and drying in the shades exhibited a better performance compared to the other drying methods (drying under the sun, in the oven, and in the microwave) (P<0.05). For Geranial, Neral and Citronella drying under the sun and in the oven proved to be the best methods, respectively. Increasing the oven temperature negatively affects the Lemon Balm’s essential oil. It could be suggested to use mycorrhiza in order to improve the Lemon Balm yield. Additionally, saving time and expenses are among the other benefits of rapid drying methods, such as a low-temperature oven and the low-output power of the microwave.
      PubDate: 2022-09-14
      Issue No: Vol. 9, No. 3 (2022)
       
  • An Investigation Into The Effect Of Carbon Nanotube-Based Nanocomposites
           On The Electrical Conductivity Of Polyester

    • Authors: Fatemeh.Ghazanfari1 ; Zarrin Eshaghi2
      Pages: 79 - 86
      Abstract: This research has been done by adding functionalized nanocomposites to flock powder (polyester) to increase the electrical conductivity. This method is a simple and cost-effective method, which has been used to activate polyester flock fibers. In the industrial method, to activate (increase the electrical conductivity) of polyester fibers, the method of adding moisture has been used, which has led to the improvement of the electrical conductivity. However, at the laboratory level, the method of adding functionalized nanocomposites to polyester fibers was used. For this purpose, functionalized nanocomposites with different percentages were added to flock powder (polyester fibers) during different processes. In this method, first oxidized nanotubes are synthesized, then surfactants are added and nanocomposites are added to polyester fibers with different percentages. For optimization, parameters such as pH, percentage of increase in operating nanocomposites, sonic time, centrifuge speed, diffraction rate, rate of change in electrical conductivity of polyester fibers were investigated.
      PubDate: 2022-09-14
      Issue No: Vol. 9, No. 3 (2022)
       
  • GC-MS Analysis And In Vitro Study Of Antifungal,Antiurease And
           Anticholinesterase Potentials Of Origanum Compactum Benth.Essential Oil

    • Authors: Nesrine SADAOUI-SMADHI ; Ali DEBBI , Chawki BENSOUICI , Ibrahim BELHI , Nabil KADRI , Souheyla TOUBAL , Narimen BENHABYLES , Siham AKMOUSSI-TOUMI , Souad KHEMILI-TALBI
      Pages: 87 - 100
      Abstract: Origanum compactum is widely used as foods and in traditional medicine, considering the increasing use (culinary and medicinal) of this plant with beneficial effects on health and in search of new biomolecules with therapeutic effects. The current study aimed to investigate, the chemical composition of O. compactum essential oil prepared from the aerial parts and to provide data on its antifungal, anti-urease and anticholinesterase activities. O. compactum essential oil (EO) was analyzed by GC-MS, antifungal activity was carried out by the measurement of the radial growth of the fungus. Acetylcholinesterase (AChE), butyrylcholinestérase (BuChE) and urease inhibitory activity assays were used to determine enzyme inhibition capacity of the essential oil. The GC-MS analysis revealed carvacrol (53.38 %) and thymol (21.16 %) as the major compounds. The essential oil exhibited an antifungal effect against Fusarium. oxysporum f.sp. lycopersici (at 0.01% of the essential oil, 50.53 ± 2.13% of mycelia growth was inhibited). Urease activity was inhibited with an IC50 of 74.52±3.35 µg/ml. In addition, the investigation of anticholinesterase potential revealed a moderate acetylchlinesterase and butyrylcholinesterase  inhibitory effects with an IC50 value of 103.25±1.86 µg/ml  and 69.89±3.32µg/ml, respectively. This is the first study that demonstrates that essential oil  can lead to inhibition of urease and butyrylcholinesterase enzymes. According to these results, O. compactum essential oil could be a source of bio-fungicide, antiurease agents and an effective source of components having anticholinesterase activity.
      PubDate: 2022-09-15
      Issue No: Vol. 9, No. 3 (2022)
       
  • Formulation And In-Vitro Evaluation Of Candesartan Cilexetil Loaded
           Nanosponges For Solubility And Dissolution Enhancement

    • Authors: Dr. Rajkumar S. Moon ; Mahesh Desale , Pallavi Kamble
      Pages: 101 - 114
      Abstract: Candesartan cilexetil (CC), a antihypertensive drug, a selective AT1 subtype angiotensine II receptor antagonist. CC is a BCS class II drug and has poor water solubility and dissolution rate, which results in a low bioavailability. In the present investigation an attempt has been made to increase the solubility of candesartan cilexetil by preparing nanosponges containing CC using ethyl cellulose and eudragit rs100 by emulsion solvent diffusion method. Nanosponges loaded with CC (CN1-CN8) were synthesized and thoroughly evaluated in terms of physicochemical attributes. Amongst all, CN3 was recognized as an optimized formulation with Particle Sizes (PS): Mean PS (756nm), Z-Average PS (1721.5nm), Poly Dispersity Index (0.844), Zeta potential (-21.1Mv), and Entrapment Efficiency (EE=85.06%).The prepared nanosponges containing CC were further characterized by FTIR, SEM image of optimized nanosponges revealed particles were spherical and spongy in nature. Saturation solubility of batches CN1-CN8 were performed and batch CN3 found to have highest solubility (10.22µg/ml). The dissolution of CN3 (78.57%) was also found to be improved as compared to pure CC (36.7%). Thus nanosponge technique may a potentially effective method for increasing solubility and dissolution rate of poorly water soluble drugs.
      PubDate: 2022-09-19
      Issue No: Vol. 9, No. 3 (2022)
       
 
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