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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
Showing 1 - 15 of 15 Journals sorted alphabetically
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 4)
Acupuncture in Medicine     Hybrid Journal   (Followers: 16)
Advanced Herbal Medicine     Open Access   (Followers: 9)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 4)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 2)
Alternative & Integrative Medicine     Open Access   (Followers: 13)
Alternative Medicine     Full-text available via subscription   (Followers: 3)
Alternative Medicine Studies     Open Access   (Followers: 7)
Anales de Hidrología Médica     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 3)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 3)
Asian Journal of Plant Pathology     Open Access   (Followers: 5)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 2)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 10)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 4)
BMC Complementary Medicine and Therapies     Open Access   (Followers: 18)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine     Open Access   (Followers: 3)
Chinese Medicine and Culture     Open Access   (Followers: 4)
Cognitive Neuroscience     Hybrid Journal   (Followers: 33)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 19)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 19)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 3)
Erfahrungsheilkunde     Hybrid Journal  
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 25)
Experimental and Therapeutic Medicine     Full-text available via subscription  
Fitoterapia     Hybrid Journal   (Followers: 5)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 12)
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access  
Global Journal of Traditional Medicine     Open Access  
Herba Polonica     Open Access  
Herbal Medicines Journal     Open Access   (Followers: 1)
Indian Journal of Ayurveda and lntegrative Medicine Klue     Open Access   (Followers: 2)
Indian Journal of Research in Homoeopathy     Open Access  
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 1)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 2)
Intas Polivet     Full-text available via subscription   (Followers: 1)
Integrative Medicine Research     Open Access   (Followers: 4)
International Journal of High Dilution Research     Open Access  
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
International Journal of Yoga     Open Access   (Followers: 17)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 8)
Ipnosi     Full-text available via subscription  
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Journal of Agromedicine and Medical Sciences     Open Access   (Followers: 6)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 15)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 2)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 2)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Journal of Ayurveda     Open Access   (Followers: 3)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 6)
Journal of Ayurveda Case Reports     Open Access   (Followers: 1)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 7)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 19)
Journal of Complementary and Alternative Medical Research     Open Access   (Followers: 1)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 12)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Fasting and Health     Open Access   (Followers: 1)
Journal of Ginseng Research     Open Access   (Followers: 1)
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 2)
Journal of Health Sciences Scholarship     Open Access  
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 2)
Journal of Integrative Medicine & Therapy     Open Access  
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 18)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Palliative Medicine     Hybrid Journal   (Followers: 55)
Journal of Research in Ayurvedic Sciences     Open Access   (Followers: 1)
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription  
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 3)
Journal of Traditional Chinese Medical Sciences     Open Access  
Médecine Palliative     Full-text available via subscription   (Followers: 1)
Medical Acupuncture     Hybrid Journal   (Followers: 5)
Medicines     Open Access   (Followers: 1)
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Muller Journal of Medical Sciences and Research     Open Access   (Followers: 1)
Natural solutions     Full-text available via subscription  
Natural Volatiles & Essential Oils     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Alternative Medicine     Open Access  
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Research Journal of Pharmacognosy     Open Access  
Revista Internacional de Acupuntura     Full-text available via subscription  
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
Traditional & Kampo Medicine     Full-text available via subscription  
Traditional Medicine Journal     Open Access  
World Journal of Acupuncture - Moxibustion     Full-text available via subscription  
World Journal of Traditional Chinese Medicine     Open Access  
Yoga Mimamsa     Open Access   (Followers: 3)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 1)

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Herbal Medicines Journal
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2538-2144
Published by Lorestan University of Medical sciences Homepage  [1 journal]
  • Effects of Zataria Multiflora, Mentha Longifolia, and Origanum Vulgare
           Plant Essential Oils on the Inhibition of Candida Albicans

    • Authors: pegah shakib, Roya Malek Hossrini, Farbod Teymouri, Mohammad Arjomandzadegan, Mohammad Reza Zolfaghari*
      Abstract: Background and Aim: In recent years, yeast, particularly Candida species, has been the most common fungus separated from human infections. In this research, effects of essential oils of some plants on the clinical strains of Candida albicans were examined. Materials and Methods: Forty clinical strains of Candida were obtained from the Infectious Diseases Research Center of Arak University of Medical Sciences. After preparing the essential oils of Zataria multiflora, Mentha longifolia, and Origanum vulgare, the minimum inhibitory concentration (MIC) of the essential oils against Candida albicans strains was determined. the Morphological changes at different times were investigated using the negative staining method and a transmission electron microscope (TEM). Results: The results of the disc diffusion test indicated that the highest resistance rates in 0.625 mg/ml of O. vulgare, M. longifolia, and Z. multiflora essential oils were 31(77.5%), 15(37.5%), and 13(32.5%), respectively. The lowest MIC was related to Z. Multiflora essential oil (0.625 mg/ml). After treatment with the essential oils, the yeasts immediately decreased at zero hour. This decrease became more noticeable with the passage of time and reached the minimum number after 24 hours. Moreover, electron microscope images showed changes in the morphology of the yeasts. Conclusion: Zataria multiflora, Mentha longifolia, and Origanum vulgare essential oils, particularly Zataria multiflora, had antimicrobial effects against Candida albicans that were isolated to be studied. Thus, Zataria multiflora essential oil can be used as an anti-candida agent in the preparation of antifungal compounds
      PubDate: 2023-08-27
      DOI: 10.22087/hmj.v7i3.1023
      Issue No: Vol. 8, No. 3 (2023)
  • The Antiviral Potential of Medicinal Plants in Treating Viral Infections

    • Authors: Amin Jaydari*, Elahe Sobhani, Shahriyar Mehrabi
      Abstract: Recently, there has been remarkable progress in the field of antiviral herbal therapy owing to increasing concerns about the development of drug resistance and limited advances in the field of antiviral drug discovery. In almost all countries, medicinal plants have been widely used throughout history for the treatment of diseases and infections as traditional healing remedies due to their broad therapeutic spectrum and minimal or no side effects. As synthetic antiviral drugs are not available against most of the viral agents, hence all possible efforts have been focused on the search for new drugs and complementary alternative medicines from different herbal formulations. Despite their long history of use, the research and scientific evidence regarding the use of medicinal plants and natural products as prophylactics, therapeutics, and their health multiple beneficial applications have only gained momentum in the past few decades. Many scientific studies have been undertaken, which range from the separation of active substances to the comprehension of the therapeutic mechanisms of antiviral herbs, their potent applications in the neutralization of viral pathogens and clinical trials. Consequently, hundreds of herbs and plant metabolites have been screened, identified, and tested for their antiviral activities; fortunately, some have shown significant medicinal activity in the preventing or ameliorating of various viral diseases such as: Rabies, Influenza types A, B and C, Hepatitis B and C in both preclinical and clinical studies.
      PubDate: 2023-08-23
      DOI: 10.22087/hmj.v8i3.960
      Issue No: Vol. 8, No. 3 (2023)
  • An Investigation of the Protective Effects of the Hydroalcoholic Extract
           of Persian Yellow Rose (Rosa foetida Herrm.) on Rats with Parkinson's
           Disease Induced by 6-Hydroxydopamine

    • Authors: Nahid Jivad*, Zahra Forouzandeh Shahraki, Amir Mahdi Naseri
      Abstract: Background and Aim: This study was carried out to investigate the protective impacts of Rosa foetida extract on Parkinson's disease. Materials and Methods: Seventy rats were divided into 7 groups of 10, including a sham group, the Parkinsonian group (received 6OHDA), pretreatment and post-treatment groups with Persian yellow rose extract (150 mg/kg and 300 mg/kg), and the positive control (L-DOPA). Animal behavior was evaluated using behavioral tests, including muscle stiffness test, rotarod, and elevated body swing test (EBST). The data were analyzed using SPSS statistical software. Results: The frequency of turning to the right in the EBST test, the muscle stiffness score, and the right as well as left-hand scores in the muscle stiffness test were significantly higher in the Parkinsonian group than in the sham group (P<0.05). The frequency of turning to the right in the post-treatment group with Persian yellow rose extract in doses 150 and 300 mg/kg and in pre-treatment with Persian yellow rose extract in dose 300 was significantly lower than that of the Parkinsonian group (P<0.05). The score of the left and right hand in the pre-treatment group of Persian yellow rose extract at a dose of 300 significantly decreased compared with the Parkinsonian group (P<0.05). The time to maintain balance in the rotarod test was significantly reduced in the Parkinsonian group compared with the sham, and post-treatment as well as pre-treatment groups with different doses of Persian yellow rose extract (P<0.05). Conclusion: According to the results of this study, it can be said that the Persian yellow rose extract protects nerve cells against oxidative damage caused by 6-hydroxydopamine and improves motor symptoms and balance disorders caused by Parkinson's disease.
      PubDate: 2023-08-23
      DOI: 10.22087/hmj.v8i1.964
      Issue No: Vol. 8, No. 3 (2023)
  • An Evaluation of Anti-Microbial Properties of Gelatin and Collagen Films
           Enriched by Aloe Vera and Henna to Build an Organic Band Aid

    • Authors: Bayan Khoshkalam*, Ramin Manaffar, Nooshin Sohrabi, Nabi Khaliliaqdam
      Abstract: Today, the idea of ​​using biodegradable polymers which can naturally replace skin shortly before skin repair while also inhibiting the growth of bacteria causing wound infection is of great interest. The purpose of this study was to investigate the possibility of making degradable films using natural compounds, including chicken gelatin and collagen, henna plant extract, and aloe vera gel. Materials and Methods: Aloe vera gel and ethanolic extract of the henna plant were prepared and their antioxidants were studied by DPPH (Diphenylpicrylhydrazyl) free radical-scavenging assay. Then, the antimicrobial properties of henna extract and aloe vera gel were evaluated against Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the disk diffusion method along with the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. To prepare the films, the gelatin and collagen extracted from chicken, along with the ethanolic extract of henna and aloe vera gel, was used. Subsequently, the physicochemical and mechanical properties (elasticity, dissolution potency, and moisture level and microscopy investigation) of the films as well as the antimicrobial properties of films against these microbes were investigated. Results: The results revealed that the anti-microbial effects of henna extract and aloe vera gel alone and in combination with gelatin/collagen matrix varied and had different effects on the tested microbes. Moreover, aloe vera showed stronger antioxidant properties than henna. Conclusion: When synthesizing gelatin/collagen-based biopolymers, plant compounds and extracts can be used to enhance the antioxidant and antibacterial properties and apply organic band aids to help heal wounds and prevent wound infections.
      PubDate: 2023-08-23
      DOI: 10.22087/hmj.v8i1.1000
      Issue No: Vol. 8, No. 3 (2023)
  • Effects of the Topical Application of Lavandula Officinalis L. Essential
           Oil on Reducing the Severity of Eczema Symptoms: A Randomized Clinical

    • Authors: Marzieh Rashidipour, Mojgan Zarei Venovel, Forouzan Ahmadpour*, Farzad Ebrahimzadeh, Hossein Matoorian Pour, Samaneh Hadavand, Asma Alekasir
      Abstract: Background and Aim: Lavandula Officinalis L. essential oil (L.O) has different effects such as anti-inflammatory and soothing effects on skin diseases. The aim of this study was to examine the the effect of L.O on the severity of eczema. Materials and Methods: This research was conducted as an open-label, randomized clinical trial. The patients who were enrolled to participate in the present study were randomly divided into five groups. In groups A, B, and C, 15 patients in each group received lavender essential oil cream at a dose of 3%, 5%, and 8%, respectively. In groups D and E, 15 patients in each group received 1% topical hydrocortisone and cream base, respectively. All the patients used the cream twice a day for 14 days. Baseline characteristics of the enrolled subjects and illness severity were recorded at the baseline and during the 7th as well as 14th days. Results: Generalized estimating equations (GEE) method showed that the interaction of the experimental group and time factor on the severity of eczema was significant (P = 0.011). Moreover, the relative chance of higher eczema severity in experimental groups was different, and it was a function of time. The relative chance of any increase in the severity of eczema in groups A, B, C compared with group E on the 7th day of treatment was reduced by about 9.7%, 34.7%, and 73.9%, respectivelyt; while on the 14th day of treatment, it decreased by about 79.2%, 82.4%, and 97.7%, respectively. The lavender oil significantly reduced the severity of eczema at the 7th and end of the 14th day (P ≤ 0.01). Conclusion: Lavender has dose-dependently beneficial effects on the treatment of eczema.
      PubDate: 2023-08-23
      DOI: 10.22087/hmj.v8i2.936
      Issue No: Vol. 8, No. 3 (2023)
  • Detection of Aflatoxins in Peanut Samples Using HPLC in Isfahan, Iran

    • Authors: pegah shakib*, Mahboobeh Madani*, Arezoo Azarm, Mohammadali Zia, Reza Mohajer
      Abstract: Background and Aim: Aspergillus, Fusarium, and Penicillium are fungi commonly found in farm produce, including peanuts, that can produce mycotoxins such as Aflatoxin. Aflatoxins are toxic byproducts of fungal metabolism that can cause cancer. They are found in various food items. This study aimed to identify Aflatoxins in peanut specimens using HPLC in Isfahan, Iran. Materials and Methods: One hundred fifty 300-gram peanut samples were collected from markets in Isfahan province, Iran, and cultivated on Sabouraud glucose agar (SDA). The fungi were classified using the standard slide culture technique, and aflatoxin analysis was performed using the HPLC approach. Results: The most prevalent isolated fungi among the 150 peanut specimens were Aspergillus, Penicillium, and Rhodotorula. The occurrence of total aflatoxin, AFB1, AFB2, AFG1, and AFG2 were 85%, 85%, 74%, 35%, and 45%, respectively. 5% of peanut samples exceeded the maximum permissible limits (5 and 15 µg/kg) for AFB1 and total aflatoxins, respectively, as established by European Union guidelines. Conclusion: The results suggest that peanuts are an appropriate medium for various fungal growth and mycotoxin formation, emphasizing the significance of testing peanuts for aflatoxin and fungal contamination before distributing them to the general public.
      PubDate: 2023-08-23
      DOI: 10.22087/hmj.v7i4.933
      Issue No: Vol. 8, No. 3 (2023)
  • Targeting and Inhibiting Plasmodium berghei Growth in Balb/c Mice Using
           Kojic Acid-Solid Lipid Nanoparticles and Kojic Acid-Nanostructured Lipid

    • Authors: Mehdi Nateghpour*, Aref Faryabi, Afsaneh Motevalli Haghi*, Khadijeh Khezri, Bahman Rahimi-Esboei, Abbas Rahimi Foroushani, Nader Shahrokhi, Amir Amani, Fatemeh Bayat
      Abstract:   Background and Aim: Malaria is a life-threatening infection in the world. The emergence of strains of Plasmodium species that are resistant to anti-parasitic drugs, and the lack of licensed high-performance malaria vaccines have raised serious concerns worldwide. In recent years, new treatment strategies such as nanoformulations have been suggested as effective drug delivery systems to enhance the therapeutic efficiency of various drugs. Materials and Methods: In this study, kojic acid-solid lipid nanoparticles (KA-SLNs) and kojic acid-nanostructured lipid carriers (KA-NLCs) were synthesized using high-speed homogenization and ultra-probe sonication methods to improve their antiplasmodial activities. The obtained nanoformulations were evaluated against the Plasmodium berghei malaria parasite in mice. Anti-plasmodium activities and cytotoxicity of the nanoparticles were assed. Furthermore, the spleen and liver biochemical analyses of the subjected mice were evaluated for each group of mice in comparison with the control group. Fifty percent effective dose (ED50) was calculated as well. Moreover, ex vivo human red blood cells (RBCs) hemolysis was assessed. Results: Kojic acid solution was significantly effective in all concentrations on the seventh day (D7) and the tenth day (D10) (P. value <0.05). The toxicity test revealed no toxic impact on the subjects. ED50 was obtained at 150 mg/kg concentration for KA-NLCs and 400 mg/kg concentration for KA-SLNs on D10. The results of the evaluation of KA nanoformulations and KA solution on RBCs indicated that KA nanoformulations could reduce the lysis of RBCs.  These results also showed that the lysis of RBCs increased with raising drug concentration in KA nanoformulations, and KA-NLCs (100 mg/kg) gave the least lysis. KA nanoformulations (especially KA-NLCs) and KA solution significantly reduced parasite growth. Conclusion: These results revealed that the KA solution was safe and had no side effects on the subjects in the range of evaluated concentrations. Moreover, the results of this study showed that
      PubDate: 2023-08-23
      DOI: 10.22087/hmj.v7i3.991
      Issue No: Vol. 8, No. 3 (2023)
  • In vitro Screening of Glutathione- S -Transferase Inhibition by Different
           Extracts of Verbascum sinuatum

    • Authors: Lubna Abdallah*, Aseel Abu Hardan
      Abstract: Background and Aim: The concern toward using herbs as enzyme inhibitors such as glutathione-s-transferases (GSTs) may result in the improvement of proliferative diseases. Moreover, it may overcome the problem of multidrug resistance tumors. Based on that, this experiment was conducted to detect the impact of using aqueous, ethanol and methanol extracts from Verbascum sinuatum L. (Scrophulariaceae) that grow wild in Palestine as enzymatic inhibitors. Materials and Methods: The impacts of these three extracts at four studied concentrations (250, 500, 750 and 1000 µg/mL) on the activity of purified hepatic glutathione-s-transferases were estimated spectrophotometrically by using-chloro-2,4-dinitro-benzene (CDNB) as substrate. Results: The results of the present research indicated that all the three prepared extracts of V. sinuatum could inhibit the activity of GSTs at all examined concentrations. Moreover, according to the results, the alcoholic extracts from the studied plant species were more influential in the activity of GSTs than the aqueous ones. However, minor inhibitory variations were observed between methanol and ethanol extracts. It is notable that all the studied extracts manifested inhibitory effects in a dose-dependent manner. Conclusion: The results of this study emphasized the possibility of utilizing V. sinuatum extracts in pharmaceutical industry of new medications to fight drug resistant tumors in general and GST-induced tumors in particular.
      PubDate: 2023-08-22
      DOI: 10.22087/hmj.v7i3.901
      Issue No: Vol. 8, No. 3 (2023)
  • Investigating the cytotoxicity of the Ziziphus jujuba L., Ribes
           khorasanicum, Crocus sativus petal, and Centella asiatica extracts on the
           NIH/3T3 cell line

    • Authors: Samira Shahraki, Fatemeh Shahbeiki, Reza Mohebbati*
      Abstract: Background and aim: Medicinal plants are utilized for treating different diseases in humans and the use of Ziziphus jujuba L., Ribes khorasanicum, Crocus sativus petal, and Centella asiatica for treating various diseases is increasing. In the current work, we investigated the cytotoxicity effect of Ziziphus jujuba L., Ribes khorasanicum, Crocus sativus petal, and Centella asiatica hydroalcoholic extract on the cell viability and morphology of the mouse embryonic fibroblast NIH/3T3 cell line. Materials and Methods: We prepared hydroalcoholic extracts of Ziziphus jujuba L., Ribes khorasanicum, Crocus sativus petal, and Centella asiatica, and NIH/3T3 cell line was treated with various concentrations (78.1, 156.5, 312.5, 625, 1250, 2500, and 5000 μg/ml) of four hydroalcoholic extract. Afterward, we investigated Cell viability with MTT assay and morphological changes using an inverted light microscope after 24h and 48 h. Results: Our results indicated that hydroalcoholic extracts of the Ziziphus jujuba L. and Ribes khorasanicum induce less toxicity and morphological change in the NIH/3T3 cells. NIH/3T3 cells exposed to several concentrations of Crocus sativus petal and Centella asiatica hydroalcoholic extract reduced cell viability and showed morphological changes such as decreased number of live cells, and lost their spindle-like shape compared to the control group in a dose-dependent manner. Conclusion: Our findings demonstrated that all extracts including Crocus sativus petal, Centella asiatica, Ziziphus jujuba L. and Ribes khorasanicum have not any cytotoxicity effects on NIH/3T3 cell line due to high IC50 although the safety of the Ziziphus jujuba L. and Ribes khorasanicum is more than the Crocus sativus petal, Centella asiatica.
      PubDate: 2023-06-05
      DOI: 10.22087/hmj.v7i3.986
      Issue No: Vol. 8, No. 2 (2023)
  • A Comparison of Antibacterial Effects of Licorice Root Ethanolic Extract,
           Chlorhexidine, and Doxycycline on Fusobacterium nucleatum: An in Vitro

    • Authors: Mohammadreza Tabatabaeian, Vahid Esfahanian*, Arezoo Tahmourespour
      Pages: 53 - 60
      Abstract: Background and Aim: Antibiotics and mouthwashes which are used to prevent and treat periodontal diseases have side effects such as antibiotic resistance, mouth burning, and xerostomia. With the advancement of technology, plants have been considered as alternative antibacterial agents. Licorice plant with different species has been used in traditional medicine to treat gastritis and respiratory diseases. Considering the properties of licorice in traditional medicine, this study aimed to investigate the antibacterial properties of licorice root extract with different concentrations compared with Chlorhexidine mouthwash and Doxycycline antibiotic on Fusobacterium nucleatum in vitro. Materials and Methods: After the preparation of 0.5 McFarland bacterial suspension, the plant and its ethanolic extract, and six extract dilutions were also prepared. Agar disk diffusion and broth microdilution tests were carried out against Fusobacterium nucleatum ATCC 2558. The antibacterial effect of Chlorhexidine mouthwash 0.2% and Doxycycline 100 mg antibiotic were also determined to be compared with licorice extract. The data were analyzed using Mann-Whitney and Kruskal-Wallis statistical tests in spss26 software at a significance level of 5%. Results: All the six concentrations had significant antibacterial effects compared with each other, chlorhexidine and doxycycline (P-value<0.05). The inhibitory concentrations of extract, MIC50, MIC70, and, MIC90 were related to 12/5, 50, and 200 mg/ml, respectively. The inhibitory percentages of chlorhexidine and doxycycline were 67.6% and 88.7%, respectively. Conclusion: Licorice ethanolic extract exhibited an excellent antimicrobial effect (MIC=6.25mg/ml), so that in concentrations higher than 25, a greater antimicrobial effect was observed than in chlorhexidine (P<0.05).
      PubDate: 2023-05-19
      DOI: 10.22087/hmj.v7i2.999
      Issue No: Vol. 7, No. 2 (2023)
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