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Journal of Natural Remedies
Journal Prestige (SJR): 0.154
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2320-3358
Published by Informatics Publishing Limited Homepage  [20 journals]
  • Concerning the Article - A Perspective Review on Siddha System of Medicine
           in the Management of Corona Virus Disease 2019

    • Authors: Samraj Karunanithi, Rajalakshmi Shanmugam
      Pages: 121 - 122
      Abstract: No Abstract.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28706
      Issue No: Vol. 22, No. 2 (2022)
  • A Review on Herbal Remedies for Alzheimer’s Disease

    • Authors: Sarthak Prashant Mehta, Ramachandran Balaraman
      Pages: 123 - 135
      Abstract: Among the neurodegenerative disorders, Alzheimer’s disease is the most common type where the individual suffers from dementia. It usually affects citizens aged 65 and above. Its high prevalence and debilitating effects call for the need of effective therapeutic interventions to deal with this grave disease. The inefficiency of currently available therapeutic options pushes our attention towards finding effective alternative therapeutic options to either successfully prevent or treat AD. Herbal remedies are a potential gold mine that offer hope against this crippling disease. The aim of this review is to throw a light on the potential of a few potential and promising herbal which can provide an alternative therapeutic intervention for the prevention and management of AD amongst a plethora of herbal drugs.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/29277
      Issue No: Vol. 22, No. 2 (2022)
  • Evaluation of Antioxidant and Antimicrobial Potential of Green Synthesized
           Ag Nanoparticles from Ethanolic Leaf Extract of Thespesia populnea

    • Authors: S. Charulatha, H. V. Dharrunya, R. Dhanamurugan, R. Devadharshini, Debanjoy Paul, M. E. Sinduja, J. Bindhu
      Pages: 137 - 144
      Abstract: Thespesia populnea is a variety of small tree found mostly in the tropical regions of the world belonging to the family of Malvaceae. According to ancient and traditional medicine such as Ayurveda this plant is used to treat various diseases such as bloody diarrhea, fracture healing, urinary tract problem, abdomen swelling, pleurisy, skin disorders, high fever and menstrual issues. This study focuses on the evaluation of antioxidant and antimicrobial activities of synthesized silver nanoparticles from aqueous leaf extract of Thespesia populnea plant. Reducing capability of synthesized nanoparticles was examined by carrying out various antioxidant assays such as reduction of DPPH substrate through radical scavenging. It showed the maximum reduction of DPPH as 92.77% at 120 'g/mL concentration. At 120 'g/mL concentration, phosphomolybdenum showed highest contraction percentage ranging 51.47 % and followed by Fe3+ reduction at 28.78 %. Studies on antimicrobial activity has revealed that the maximum zone of inhibition was exhibited by Proteus vulgaris with distinct zone formation up to 19 mm diameter.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/26226
      Issue No: Vol. 22, No. 2 (2022)
  • Butanol Fraction of Rivea ornata Attenuate Endothelial Dysfunction in Rats
           via Modulation of Cardiovascular Risk Factors

    • Authors: Mallela Vijaya Jyothi, Nayakanti Devanna, Akkiraju Sudheer
      Pages: 145 - 159
      Abstract: Atherosclerosis is caused by vascular inflammation and oxidative stress. Pro-atherogenic effect of hypercholesterolemia caused by impairment of nitric oxide generation due to activated arginase. The study takes up to find the atheroprotective role of polyphenolic fraction of Rivea ornata leaves by using lipid emulsion induced atherosclerosis in rat model. The study carried out by studying atherogenic markers in the serum (lipid profiles, C-reactive protein), vascular tissue (myeloperoxidase, arginase, hydroxyproline, lipid peroxidation) and atheroprotective factors in the serum (paraoxonase, nitric oxide), and in the vascular tissue (thiol levels, endogenous antioxidants) after feeding the rats with lipid emulsion for 12 weeks. Treatment of polyphenolic rich butanol fraction is able to correct the imbalance of atherogenic and antiatherogenic factors induced by lipid emulsion feeding. Butanol fraction at the dose of 400 mg/kg significantly increases high density lipoprotein, paraoxonase, nitric oxide, tissue thiol levels, endogenous antioxidants and decreases total triglycerides, total cholesterol, very low-density lipoprotein, low density lipoprotein, myeloperoxidase, arginase, hydroxyproline, lipid peroxidation. The atheroprotection reflected in histopathology studies also. Lipid emulsion associated foam cells formation is inhibited by butanol fraction. These all are due to the presence of gallic acid in polyphenol rich butanol fraction is responsible for the underlying mechanism of atheroprotection.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/27855
      Issue No: Vol. 22, No. 2 (2022)
  • Development and Evaluation of a Polyherbal Tablet for Polycystic Ovarian
           Syndrome (PCOS)

    • Authors: Disha Prajapati, Madhavi Patel, Abhay Dharamsi
      Pages: 161 - 174
      Abstract: The main objective of the present study was to develop and evaluate polyherbal tablet for the treatment of Polycystic Ovarian Syndrome (PCOS). For the formulation of tablet, the herbs were selected based on the concepts of pathophysiology and Ayurvedic perspective of the disease. The extracts of T. foenum graceum, C. longa, B. aristata, S. asoka, B. variegata and Guggul purified in cow’s urine was used for the preparation of polyherbal tablet. The physicochemical, phytochemical evaluation and quantification of markers by HPTLC of crude drugs and extracts were performed. The guggul was used as binder in different proportion for the preparation of tablet. Pre-formulation study of the powder blend and post compression evaluation of tablet was done by various parameters like weight variation, friability, hardness, thickness, diameter, disintegration time, in-vitro dissolution and accelerated stability study. The physicochemical evaluations of crude drugs yielded results which were in accordance with the monograph’s standard values. The phytochemical analysis of the extracts revealed the presence of variety of phytoconstituents. From the results of HPTLC quantification the amount of curcumin (7.14%) in C. longa, diosgenin (40.6%) in T. foenum graceum ,T. foenum graceum, berberine hydrochloride (4.83%) in B. aristata, catechin (3.48%) in S. asoka, lupeol (0.11%) in B. variegata and Z-guggulsterone (0.140%) and E-guggulsterone (0.146%) in purified guggul was found. The micrometrics of the powder blend of all the formulations showed good flow properties. Formulation F3 showed better results compared to other formulations in post compression evaluation. Accelerated stability study showed that the formulation F3 was stable during the course of study.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28557
      Issue No: Vol. 22, No. 2 (2022)
  • Bauhinia variegata Bark Extract: Assessment of its Anti-proliferative and
           Apoptotic Activities on A549 and H460 Lung Cancer Cell Lines

    • Authors: Tanvi Khanna, Akash Dave, Sejal Purani, Jagath Vedamurthy, Dhaval Jivani, Pushpa Robin
      Pages: 175 - 195
      Abstract: The hunt for novel anticancer drugs with minimal side effects continues. This study strengthens the claim by providing biochemical evidences of anticancer activities of Bauhinia variegata bark extracts on lung carcinoma cells (A549 and H460). Bark extracts of Bauhinia variegata were prepared by different solvents using Soxhlet apparatus and tested for their antioxidant potential by DPPH assay. The lung cancer cell lines were treated with Bauhinia variegata bark extracts and viability of cells was measured by MTT assay; metastatic ability was determined through Scratch assay and effect on DNA integrity was shown by gel electrophoresis. The Petroleum Ether Bark Extract (PEBE) inhibits proliferation (A549, IC50 = 1.5 mg/ml) at 48 h treatment. DNA damage was observed in A549 cells by agarose gel electrophoresis. The Chloroform Bark Extract (CBE) inhibited proliferation of H460 (IC50 = 1 mg/ml) with DNA damage after 24 h treatment. Soft agar assay indicated decreased ability to form colonies and scratch test showed impaired migration of A549 and H460 to PEBE and CBE treatment respectively. Apoptosis was detected using fluorescent dye staining in A549 and H460 cells. Caspase 3 activity was increased significantly in A549 and H460 cells. PEBE and CBE decrease the mitochondrial membrane potential gradient (''m) of A549 and H460 cells respectively. This study categorically proves the cytotoxic activity of Bauhinia variegata bark extracts on A549 and H460 cells.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28740
      Issue No: Vol. 22, No. 2 (2022)
  • Caloric Value of Biomass based Power Plants, Life Cycle Assessment and
           Techno Economic of Different Crops for M.P. (India)

    • Authors: Shashikant Sharma, Sunil Kumar Gupta, Mukesh Pandey
      Pages: 197 - 207
      Abstract: Solar radiation incident on green plant and other photo synthesis organism performs two basic functions such as temperature control for chemical reaction to proceed and the process of photosynthesis. The fundamental conversion process in green plant is photosynthesis which is process of combining CO2 from the atmosphere with water and light energy to produce oxygen and carbohydrates1.              X [CO2] + Y [H2O] + light energy photosynthesis X[O2] + Y [Cx H2O]                              Y [Cx H2O] is used to indicate the carbohydrates.The world population has increased at an explosive rate from 1.65 billion to just over 6 billion in the 20th century, and continues to increase. In the same century, mankind has consumed over 875 billion barrels of oil and it is very likely that even more oil will be consumed in the present century. Annual energy use in developing countries has risen from 55 to 212 kg oil equivalent over the last thirty years, while developed countries use as much as 650 kg oil equivalent per person. In his synopsis ‘Trilemma’ Three major problems threatening world survival’, foresees a three-fold challenge in the 21st century: how can we achieve economic growth, supply food and energy resources, while conserving the environment' To overcome the Trilemma, developing and introducing more efficient energy conversion technologies is therefore important, for fossil fuels as well as renewable fuels. This thesis addresses the question how biomass may be used more efficiently and economically than it is being used today. Wider use of biomass, a clean, renewable and CO2 neutral feedstock may extend the lifetime of our fossil fuels resources and alleviate global warming problems. Another advantage of using of biomass as a source of energy is to make developed countries less interdependent on oil- exporting countries, and thereby reduce political tension. Furthermore, the economies of agricultural regions growing energy crops benefit as new jobs are created1. Biomass primary energy sources: Past, present and future in particular wood, has historically been an important energy source for fires, ovens and stoves. During the Industrial Revolution, coal displaced biomass because of its high energy content and because it is available in large quantities at low cost. At the beginning of the 20th century, oil supplied only 4 % of the world’s energy. Decades later it became the most important energy source. Especially developed countries are highly dependent on oil, which supplies about 96 % of their transportation energy. With world energy demand projected to rise by about 40 % from now to 2020, photosynthesis. Rajiv Gandhi Proudyogiki Vishwvidhalaya implemented the National Policy for Management of Crop Residues to protect the parali (crop residue). On December 10, 2015, the National Green Tribunal (NGT) had banned crop residue burning in the states of Rajasthan, Uttar Pradesh, Haryana and Punjab. Burning crop residue is a crime under Section 188 of the IPC and under the Air and Pollution Control Act of 1981. The Delhi high court had also ordered against burning residues, while Punjab government imposed a penalty of Rs 73.2 lakh farmers in 2016 for burning of crop residue3.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28853
      Issue No: Vol. 22, No. 2 (2022)
  • Evaluation and Assessment of the Acute Toxic Potential of Sansevieria
           cylindrica and Plumeria obtusa Plant Extracts in Wistar Albino Rats

    • Authors: Sunil Shewale, Vaishali Undale, Vrushali Bhalchim, Shivani Desai, Maruti Shelar, Shubham Padole, Sohan Chitlange, Vikas Wawale, Sameer Parekh, Pramod Pujari
      Pages: 209 - 220
      Abstract: Sansevieria cylindrica (SC) Bojer ex Hook. (Asparagaceae) and Plumeria obtusa (PO) L. (Apocynaceae) are indoor and outdoor ornamental plants respectively. These plants are traditionally used by the local healers during accidental injuries. However, their toxicological properties are very poorly explored over folkloric usage. Therefore, the present study evaluated the toxic potencies of SC leaves and PO seed Hydro-Alcoholic Extract (SCPOHAE) through acute oral dose (14-days) administration in female Wistar rats. Safety of the SCPOHAE was evaluated as per Organization for Economic Co-operation and Development (OECD) Acute Oral Toxicity study guidelines 423. The female Wistar rats were divided into three groups (n=3). A single oral dose of 2000 mg/kg of body weight of individual extract and 1:1 blend was administered to each animal. The animals were closely observed for clinical signs, neurobehavioral changes, morbidity, and mortality if any for the first half an hour and then every hour for the first four hours followed by observation every 24–hours for 14 days. Changes in food and water consumption, body weight were monitored daily during the study. On day 1 and day 15 blood samples were collected to evaluate changes in the hematology and biochemistry parameters. The urine samples were also collected for urine analysis parameters. Animals were sacrificed on day 15 and organ samples of liver and kidney were collected for histopathological findings. The SCPOHAE individually and also as 1:1 blend at the limit dose (2000 mg/kg, body weight) did not cause death and did not induce any remarkable and abnormal clinical signs, indicative of systemic toxicity, in rats during the treatment period of 14–days. The statistically non-significant small differences in the body weight were observed. Conclusion: The oral administration of SCPOHAE did not cause any systemic toxic effects. In conclusion, the No-observed-Adverse-Effect Level (NOAEL) of these extracts in rats was found to be greater than 2000 mg/kg.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28768
      Issue No: Vol. 22, No. 2 (2022)
  • In Silico Screening of Triphala Churna against Bacterial Agents

    • Authors: L. S. Dhivya, M. Haritha, G. V. Anjana, D. Priya
      Pages: 221 - 232
      Abstract: Triphala Churna consisting Triphala and its constituents have been revealed to have antibacterial properties against human pathogens. The phenolic ring of phytochemicals has been confirmed to be toxic against microorganisms and hence responsible for antibacterial effect. It has also been found to possess antimicrobial, anti-inflammatory, anti-oxidant, and other properties. The objective of this project is to investigate which bioactive compounds of Triphala churna have antibacterial action and can protect humans from infection. The majority of the molecules in phytochemical examination were positive for ethanolic and acetone extracts and the physicochemical characteristics were within the acceptable limits. In silico data clearly explains that the compounds of Triphala churna follows Lipinski’s rule of five. The toxicity profile and ADME parameters of the compounds revealed that most of the compounds were nontoxic towards carcinogenicity, mutagenicity, and reproductive effect. Based on the energy type of interaction between these molecules and the study protein, molecular docking revealed that the three compounds from Triphala churna own the highest docking score against InhA protein: Terflavin B (-9.67 Kcal/mol), Ellagic acid (-9.37 Kcal/mol), and Corilagin (-8.57 Kcal/mol).
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28664
      Issue No: Vol. 22, No. 2 (2022)
  • In vitro Analysis of the Antimicrobial Properties of Propolis
           Collected from Jimma, Ethiopia

    • Authors: Getahun Befirdu Abza, Jemal Hussien Ahmed, Getahun Paulos, Kothai Seshathri
      Pages: 233 - 240
      Abstract: The effectiveness of antimicrobial drugs becomes uncertain due to the emergence of multidrug resistant microorganisms, which highlights the need for alternative antibacterial agents. Natural products are of great importance in the search for biologically active compounds. The present study aimed at investigating the antibacterial properties of propolis, one of the natural bee products, against S. aureus, P. aeruginosa and E. coli. Propolis was extracted using 30 %, 50 %, 70 %, and 99.9 % ethanol. The in vitro antibacterial activities of propolis extracts were evaluated by the disc diffusion method with concentrations between 500 and 4000 'g/ml. Among the extracts, the 50 % and 70 % propolis extracts showed strong antibacterial activity against all tested strains with inhibition zones ranging from 6.64 ± 0.15 to 11.99 ± 0.04 mm. P. aeruginosa was sensitive strain to the ethanolic extracts of propolis with the highest inhibition zone diameter of 11.99 ± 0.04 mm. Statistically significant differences in growth inhibition were observed among the types of extracts (30 %, 50 %, 70 % and 99.9 %) against P. aeruginosa (p < 0.05) and E. coli (p < 0.05), but the effect was not significant on S. aureus (p > 0.05). All propolis extracts showed no effect on S. aureus at concentrations below 2000 'g/ml. Propolis extracts showed a lower zone of inhibition compared to the effect demonstrated by the positive control. Overall, the results indicate that ethanolic extracts of Ethiopian propolis has a promising antibacterial activity which could be of an antibiotic development benefit.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/26587
      Issue No: Vol. 22, No. 2 (2022)
  • Designing and Recognition of Internal Transcribed Spacer Region in
           Solanum Species

    • Authors: Nibedita Dey, Shalini Devaraji, C. Kamatchi
      Pages: 241 - 247
      Abstract: Identifying the authenticity of any material has been of great importance to people for decades. The use of plant-based therapy is of great interest to people all around the world. Today 1000 of plant varieties are being investigated by many researchers for their potential pharmaceutical activities. Apart from home remedies, these plant-based therapies are drawing the attention of several western countries towards patenting them for their commercial use. Even before formulation of a drug from plants, it is very essential to the purity of the variety to ensure the quality of the final product. When it comes to genome identification the first guess is always DNA barcoding. But the redundancy of the plant species towards evolution is the main reason why the closely related plant species are very difficult to classify. The mitochondrial can be preferred for DNA barcoding but has a disadvantage when it comes to plant varieties. Hence, to find the genomic uniqueness of Solanum species from our local area we opted for the utilization of internal transcribed spacers and found to be a partial ITS2 segment. The plant species were found similar to Solanum supinum and Solanum virginianum. The size of the amplified product was found to be 314, 350 and 346 bp, with respect to Sx1, Sx2 and Sx3. Although the sequence we obtained was partial ITS, it still helped us to identify the Solanum species found in our local region with great efficiency. Proper complete ITS2 sequencing is the perspective of the future work to be done.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/27721
      Issue No: Vol. 22, No. 2 (2022)
  • Discovery of Immunomodulators from Plant Kingdom Targeting IL-6 for the
           Effective Management Therapy of SARS-CoV-2

    • Authors: Akey Krishna Swaroop, Palathoti Nagarjuna, P. Naresh, P. Shyam Sundar, S. Jubie, Jawahar Natarajan, P. Vasanth
      Pages: 249 - 260
      Abstract: The present study was conducted because of the recent scenario of this pandemic coronavirus outbreak worldwide. Currently, this disease cannot be treated through specific vaccines and therapeutic medicines. While many vaccines are being investigated, it would take some time for these to be accessible to the masses. Eventual evidence indicates that many COVID-19 patients may die from an irregular release of cytokines called as Cytokine Release Syndrome (CRS) due to the excessive reaction of their immune systems. In worsening patients with COVID-19, CRS played a significant role, from pneumonia via ARDS to cumulative systemic inflammation and eventually to a failing of the multi-system organ. In COVID-19 individuals, a large number of cytokines, including IL-6, IL-1, IL-2, IL-10, TNF- ', and IFN- ', participate in the ‘cytokine storm,’ but IL-6, whose higher serum levels are associated with respiratory failure, ARDS, and adverse clinical outcomes, tends to be a critical factor. In China, the COVID-19 mortality indicator has been tested by a multi-centre retrospective analysis in 150 COVID-19 patients. The study analysed that 82 cases are resolved from COVID-19 and 68 cases are dead due to enhancement of IL-6 levels in the serum. In this research, the secondary plant metabolites from Indian traditional medicine are identified through a computational technique and the selected seedling metabolite is sealed to block the IL-6 receptor.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28798
      Issue No: Vol. 22, No. 2 (2022)
  • Electro-Homeopathy based COVID-19 Safe-home Medical Management Study

    • Authors: G. S. Taki, Asok Kumar Mallick, Bishu Chakraborty, Prithwiraj Pal, Chaitanya Biswas, Chiranjit Samanta
      Pages: 261 - 267
      Abstract: In the middle of April 2021, the infection rate due to 2nd wave of COVID-19 attained a peak alarming level. Total COVID-19 hospital accommodation became inadequate with respect to the demand of COVID-19 patients. Several unused schools, community halls and auditoriums were converted to safe-homes for COVID-19 patients and home isolated accommodations. Two local clubs at Salt Lake, Sector 4, Kolkata was collaborated to run a COVID-19 Safe-home at Basanti Devi Vidyapith, Basanti Devi colony, at the beginning of May 2021. On behalf of the coordinators, a few Electro-Homeopathy (EH) practitioners were voluntarily engaged themselves to look after the patients. A complete report on the successful management of COVID-19 patients using Electro-Homeopathy treatment has been presented here in details. The efficacy of Electro-Homeopathy for COVID-19 treatment and in-depth details of the philosophy of EH along with EH treatment methodology has been discussed.
      PubDate: 2022-04-19
      DOI: 10.18311/jnr/2022/28201
      Issue No: Vol. 22, No. 2 (2022)
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