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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
Showing 1 - 15 of 15 Journals sorted by number of followers
Journal of Palliative Medicine     Hybrid Journal   (Followers: 52)
Cognitive Neuroscience     Hybrid Journal   (Followers: 32)
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 24)
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 18)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
BMC Complementary Medicine and Therapies     Open Access   (Followers: 17)
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
International Journal of Yoga     Open Access   (Followers: 17)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 16)
Acupuncture in Medicine     Hybrid Journal   (Followers: 16)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 16)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 14)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 12)
Alternative & Integrative Medicine     Open Access   (Followers: 10)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 10)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 9)
Advanced Herbal Medicine     Open Access   (Followers: 8)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 8)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 8)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 6)
Alternative Medicine Studies     Open Access   (Followers: 6)
Asian Journal of Plant Pathology     Open Access   (Followers: 5)
Synfacts     Hybrid Journal   (Followers: 5)
Medical Acupuncture     Hybrid Journal   (Followers: 5)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Fitoterapia     Hybrid Journal   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Ayurveda Case Reports     Open Access   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 4)
Journal of Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Chinese Medicine     Open Access   (Followers: 3)
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 3)
Yoga Mimamsa     Open Access   (Followers: 3)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Ancient Science of Life     Open Access   (Followers: 3)
Integrative Medicine Research     Open Access   (Followers: 3)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 3)
Journal of Ayurveda     Open Access   (Followers: 3)
Indian Journal of Ayurveda and lntegrative Medicine Klue     Open Access   (Followers: 3)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 3)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 2)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 2)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 2)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 2)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Alternative Medicine     Full-text available via subscription   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Ginseng Research     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine and Culture     Open Access   (Followers: 1)
Muller Journal of Medical Sciences and Research     Open Access   (Followers: 1)
Médecine Palliative     Full-text available via subscription   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Journal of Fasting and Health     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 1)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Anales de Hidrología Médica     Open Access   (Followers: 1)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 1)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Integrative Medicine & Therapy     Open Access  
Journal of Complementary and Alternative Medical Research     Open Access  
Journal of Health Sciences Scholarship     Open Access  
World Journal of Traditional Chinese Medicine     Open Access  
Natural Volatiles & Essential Oils     Open Access  
Natural solutions     Full-text available via subscription  
Traditional Medicine Journal     Open Access  
World Journal of Acupuncture - Moxibustion     Full-text available via subscription  
Indian Journal of Research in Homoeopathy     Open Access  
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Journal of Traditional Chinese Medical Sciences     Open Access  
Experimental and Therapeutic Medicine     Full-text available via subscription  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
Traditional & Kampo Medicine     Full-text available via subscription  
Research Journal of Pharmacognosy     Open Access  
Intas Polivet     Full-text available via subscription  
Global Journal of Traditional Medicine     Open Access  
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access  
Ipnosi     Full-text available via subscription  
OA Alternative Medicine     Open Access  
Herba Polonica     Open Access  
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription  
International Journal of High Dilution Research     Open Access  
Revista Internacional de Acupuntura     Full-text available via subscription  

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Journal of Evidence-Based Integrative Medicine
Journal Prestige (SJR): 0.319
Number of Followers: 18  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2515-690X
Published by Sage Publications Homepage  [1174 journals]
  • Vitamin D Supplementation Could Enhance the Effectiveness of Glibenclamide
           in Treating Diabetes and Preventing Diabetic Nephropathy: A Biochemical,
           Histological and Immunohistochemical Study

    • Authors: Tarek Atia, Mohammad Zahidul Iqbal, Hassan Fathy Ahmed, Hader I. Sakr, M. H. Abdelzaher, Deaa Fekri Morsi, Mostafa E. Metawee
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Diabetes mellitus is an oxidative stress-related disease characterized by hyperglycemia and a variety of complications, including nephropathy. Vitamin D has variable functions extending beyond the calcium metabolism to prevent oxidative tissue damage. We aimed to investigate whether vitamin D supplements could enhance Glibenclamide's effectiveness in treating diabetes and minimize the risk of associated pathology. Wistar rats were divided into normal control (n = 10) and diabetic (n = 30), where animals received two low doses of Streptozotocin 30 mg/kg/BW intraperitoneally to develop diabetes. The diabetic rats were then randomly divided into three equal groups: untreated, treated with Glibenclamide (0.6 mg/kg), and treated with Glibenclamide and Vitamin D3 (500 IU/kg). After eight weeks, the animals were sacrificed, and blood samples and kidney tissues were collected to evaluate biochemical, anti-oxidant, and pro-inflammatory cytokine levels and histological and immunohistochemical changes. Diabetic animals had significantly increased fasting blood glucose, lipid profile, blood urea, serum creatinine, and Malondialdehyde levels, whereas serum insulin, albumin, and the anti-oxidant enzymes superoxide dismutase and catalase were significantly decreased compared to normal control (p < 0.01). Furthermore, some renal histological changes were observed together with significantly increased immunoreactivity of anti-p53, anti-TNF-α, and anti-IL-6 antibodies when compared to the normal control. All abnormal parameters improved significantly with Glibenclamide therapy (p < 0.01), but combination therapy with vitamin D produced a much better result. In conclusion, vitamin D supplementation along with anti-diabetic medication can help prevent or reduce the severity of diabetic nephropathy due to its potent antioxidant, anti-inflammatory, and anti-apoptotic properties.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-08-09T06:32:59Z
      DOI: 10.1177/2515690X221116403
      Issue No: Vol. 27 (2022)
  • Hydroethanolic Extracts of Senna alata Leaves Possess Antimalarial Effects
           and Reverses Haematological and Biochemical Pertubation in Plasmodium
           berghei-infected Mice

    • Authors: Francis O. Atanu, Damilare Rotimi, Omotayo B. Ilesanmi, Jamila S. Al Malki, Gaber E. Batiha, Precious A. Idakwoji
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      The current work investigated the chemical profile, antimalarial potential and capacity of hydroethanolic Senna alata extract (SAE) to reverse hematological and biochemical pertubation in Plasmodium berghei infected mice. Results of the phytochemical analysis revealed the presence of alkaloids, flavonoids, phenolics, tannins, terpenoids, saponins, steroids and cardiac glycosides. Total phenolic and flavonoid content was estimated to be 45.29 ± 2.34 mg GAE/g and 25.22 ± 2.26 mg QE/g respectively. In vitro analysis of the extract also confirmed its antioxidant property. Results of the test for prophylaxis of P. berghei indicated that SAE suppressed parasitemia significantly in treated groups in a dose dependent manner when compared with negative control group. Similarly, SAE improved the mean survival time (MST) and packed cell volume (PCV) of infected mice. The test for curative effect showed that SAE significantly suppressed parasitemia to 4.50 ± 1.05% compared to untreated group 29.83 ± 3.49%. Results of liver and kidney functions indices of treated animals indicated that whereas infection with P. berghei caused increase in the levels of AST, ALT, ALP, urea and creatinine, treatment with SAE significantly reversed the perturbation. Similarly, infected mice were dyslipidemic with concomitant increased activity of HMG CoA reductase and decreased activity of antioxidant enzymes with increase in lipid peroxides levels. However, these alterations were significantly reversed by administration of SAE. Results of this study shows that Senna alata possess antimalarial activity and therefore justify the traditional use of plant for the treatment of malaria.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-08-05T07:00:06Z
      DOI: 10.1177/2515690X221116407
      Issue No: Vol. 27 (2022)
  • A Review of African Medicinal Plants and Functional Foods for the
           Management of Alzheimer's Disease-related Phenotypes, Treatment of HSV-1
           Infection and/or Improvement of Gut Microbiota

    • Authors: Edward Jenner Tettevi, Mahmoud Maina, David Larbi Simpong, Mike Y. Osei-Atweneboana, Augustine Ocloo
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Alzheimer's disease (AD), which is a progressive neurodegenerative disorder is the most common form of dementia globally. Several studies have suggested alteration in the gut microbiota and HSV-1 infection as contributing factors to the development of the disease. As at now, there are no AD attenuating agents and AD pharmacotherapy is focused on managing symptoms while plants used in ethnomedicine remain potential sources of drugs for the treatment of the condition. Here, we reviewed published databases for African ethnomedicinal plants and functional foods of African origin that are used in the management of AD-related phenotypes, treatment of herpes simplex virus −1 (HSV-1) and/or improvement of gut microbiota. A total of 101 unique plant species and 24 different types of traditionally prepared African functional foodstuff were identified. Of the 101 identified plant species, 50 species serve as functional foodstuffs. Twenty-three (23) of the ethnomedicinal plant families were successfully identified for the treatment and management of AD-related phenotypes and age-related dementia. Eighteen (18) African plant species from 15 families were also identified as potent remedies for HSV-1; while many African wild fruits (3 species), roots and tubers (7 species), leafy vegetables (14 species), and seaweeds (26 species) were functional foods for modifying AD-related phenotypes. It was concluded that African medicinal plants are potential sources of both AD attenuating agents and phytocompounds that may be used against HSV-1 infection and alteration of gut microbiota. Additionally, a number of African functional foods are important sources of prebiotics and probiotics.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-07-22T06:43:55Z
      DOI: 10.1177/2515690X221114657
      Issue No: Vol. 27 (2022)
  • Throat Spray With Blended Essential Oils Promotes Healthy Lung Function
           Among Women: A Randomized, Double Blinded, Placebo Controlled Clinical

    • Authors: Jessie Hawkins, Christy Hires, Elizabeth Dunne, Lindsey Keenan
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      IntroductionThere are numerous internal and external environmental threats to lung health. Compromised respiratory health can affect a person's quality of life. This clinical trial evaluated the effects of Teramune Bronchus on lung health among healthy adult women.MethodsThe participants were women, aged 18 - 60 years old (n = 35). They sprayed either the proprietary essential oil based blended product (Teramune Bronchus) or a placebo into their throats 4-6 times per day during waking hours for 3 days. There was a baseline survey before using the spray and then follow-up data were collected at the end of day 3. The three primary outcomes for this study include a total bronchial symptom score, the chest domain in the Wisconsin Upper Respiratory Symptom Scale (WURSS), and subjective bronchial wellbeing.ResultsOn day 3, the bronchial health of the participants who received the throat spray had significantly larger change scores when compared those with the placebo spray. All chest-related symptoms were resolved fully by the end of the trial for the participants who used Teramune. Participants using the intervention were almost twice as likely to say they felt better and believed the product helped them achieve lung health.ConclusionThis study provides evidence that the use of Teramune Bronchus supports respiratory health. Teramune Bronchus boosts respiratory health among healthy women through the use of plant-based essential oils.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-07-18T03:49:21Z
      DOI: 10.1177/2515690X221113335
      Issue No: Vol. 27 (2022)
  • A 30-Day Adjunct Wellness Intervention for the Management of
           Extra-Articular Symptoms of Rheumatoid Arthritis: A Formative Study

    • Authors: Tara Hutson, Nicole Murman, Donna Rolin, Rakesh Jain, Andrew J. Laster, Steven P. Cole, Saundra Jain
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Individuals with rheumatoid arthritis (RA) continually fall short of treatment targets using standard drug therapies alone. There is growing evidence that emphasizing physical and mental wellness is equally crucial for improving functioning among people with RA. The purpose of this formative study is to examine the feasibility of offering the wellness-based intervention (“KickStart30”) in patients with RA. Thirteen individuals with RA on targeted immune modulators (a biologic or JAK inhibitor) enrolled in the KickStart30 program. Participants completed self-report measures of RA-specific disability (eg, pain) and other functional areas (eg, mood) in a pre- versus post- intervention design. Paired samples t-tests (and Related-Samples Wilcoxon Signed Rank Tests for non-normal distributions) detected statistically significant results for 10 of 12 measures, including reductions in pain (M = 4.54 to M = 3.54; p = .025; BPI), functional disability (M = 0.94 to M = 0.73, p = .032; HAQ-II), cognitive and physical dysfunction (M = 25.46 to M = 13.54, p 
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-07-18T03:49:07Z
      DOI: 10.1177/2515690X221113330
      Issue No: Vol. 27 (2022)
  • Synergistic Effects of Natural Product Combinations in Protecting the
           Endothelium Against Cardiovascular Risk Factors

    • Authors: Muhammad Yousaf, Valentina Razmovski-Naumovski, Muhammad Zubair, Dennis Chang, Xian Zhou
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Endothelial dysfunction is an early hallmark of cardiovascular diseases (CVDs). Monotherapies are limited due to the complex, multifactorial pathways. The multi-component and multi-targeted approach of natural products have the potential to manage CVDs.This review aims to provide a comprehensive insight into the synergistic mechanism of natural product combinations in protecting the endothelium against various cardiovascular risk factors.Databases (PubMed, MEDLINE and EMBASE) and Google Scholar were searched, and studies in English published between January 2000 and February 2022 were collated. Clinical and pre-clinical studies of natural product combinations with or without pharmaceutical medicines, compared with monotherapy and/or proposing the underlying mechanism in protecting endothelial function, were included.Four clinical studies demonstrated that natural product combinations or natural product-pharmaceutical combinations improved endothelial function. This was associated with multi-targeted effects or improved absorption of the active substances in the body. Seventeen preclinical studies showed that natural product combinations produced synergistic (demonstrated by combination index or Bliss independence model) or enhanced effects in protecting the endothelium against hyperlipidemia, hypertension, diabetes mellitus, platelet activation, oxidative stress and hyperhomocysteinemia. The molecular targets included reactive oxygen species, Nrf2-HO-1, p38MAPK, P13K/Akt and NF-κB.Thus, the current available evidence of natural product combinations in targeting endothelial dysfunction is predominantly from preclinical studies. These have demonstrated synergistic/enhanced pharmacological activities and proposed associated mechanisms. However, evidence from larger, well-designed clinical trials remains weak. More cohesion is required between preclinical and clinical data to support natural product combinations in preventing or slowing the progression of CVDs.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-07-18T02:48:25Z
      DOI: 10.1177/2515690X221113327
      Issue No: Vol. 27 (2022)
  • A Systematic Review of Randomized Controlled Trials on Interventions
           Adopting Body-Mind-Spirit (BMS) Model on Holistic Well-Being

    • Authors: Tongtong Li, Xinyue Hu, Iris Chi
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      BackgroundThis systematic review aims to examine existing randomized controlled trials on interventions adopting Body-Mind-Spirit (BMS) model and evaluated the effectiveness of holistic well-being outcomes. Following three key concepts of the BMS model, our review questions included (1) How was BMS defined' (2) What activities were included, and how were they related to BMS dimensions' (3) What were interventionists’ backgrounds, and whether they received BMS training' (4) What were holistic outcomes' and (5) What were the effectiveness and qualities of studies'MethodsSearches were performed using nine databases for the studies published through August 2020. The process follows PRISMA protocol, and the “risk of bias” tool from the Cochrane Handbook was utilized to determine the quality of included studies.ResultsAcross 20 included studies, 18 (90%) presented a BMS definition, but only seven (35%) included all three key concepts of the BMS model. Eight studies (40%) offered detailed descriptions of body, mind, and spirit sections, and 12 (60%) mentioned cultural factors. Only five (25%) specified the body, mind, and spirit activities, and only three (15%) reported the BMS training in detail. Seven studies (35%) showed effectiveness in holistic outcomes. Only three (15%) were considered as high quality.ConclusionA unified definition of the BMS model and the guideline to apply the BMS model to design and implement interventions are highly recommended to provide a standard framework for researchers to conduct future studies. The reason for low quality is because the lack of adequate allocation concealment and blindings.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-06-02T05:24:59Z
      DOI: 10.1177/2515690X221103303
      Issue No: Vol. 27 (2022)
  • Mechanisms of Action of a Herbal Formula Huangqi Guizhi Wuwu Tang for the
           Management of Post-Stroke Related Numbness and Weakness: A Computational
           Molecular Docking Study

    • Authors: Sanghyun Lee, Andrew Hung, Hong Li, Angela Wei Hong Yang
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Stroke-related numbness and weakness (SRNW) are resultant symptoms of post-stroke sufferers. Existing research has supported the use of Huangqi Guizhi Wuwu Tang (HGWT) particularly for SRNW; however, their mechanisms of action have not been fully elucidated. Therefore, this study aimed to investigate the mechanisms of action of HGWT components targeting SRNW-related proteins through a computational molecular docking approach. Target proteins associated with SRNW were identified through DrugBank database and Open Targets database. Chemical compounds from each herb of HGWT were identified from the Traditional Chinese Medicine Systems Pharmacology and Analysis Platform (TCMSP). Autodock Vina was utilized and the cut-off criterion applied for protein-ligand complexes was a binding affinity score of ≤ -9.5 kcal/mol; selected protein-ligand complexes were identified using 3D and 2D structural analyses. The protein targets PDE5A and ESR1 have highlighted interactions with compounds (BS040, DZ006, DZ058, DZ118, and HQ066) which are the key molecules in the management of SRNW. PDE5A have bioactivity with the amino acid residues (Val230, Asn252, Gln133 and Thr166) throughout PDE5A-cGMP-PKG pathways which involved reduction in myofilament responsiveness. ESR1 were predicted to be critical active with site residue (Leu346, Glu419 and Leu387) and its proteoglycans pathway involving CD44v3/CD44 that activates rho-associated protein kinase 1 (ROCK1) and ankyrin increasing vascular smooth muscle. In conclusion, HGWT may provide therapeutic benefits through strong interactions between herbal compounds and target proteins of PDE5A and ESR1. Further experimental studies are needed to unequivocally support this result which can be valuable to increase the quality of life of post-stroke patients. Keywords Herbal medicine, Complementary and alternative medicine, Natural product, Post-stroke, Computational analysis
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-04-04T08:31:33Z
      DOI: 10.1177/2515690X221082989
      Issue No: Vol. 27 (2022)
  • Promoting Plant-Based Therapies for Chronic Kidney Disease

    • Authors: Muhammad Ali Khan, Andrew J Kassianos, Wendy E Hoy, AHM Khurshid Alam, Helen G Healy, Glenda C Gobe
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Chronic kidney disease (CKD) is debilitating, increasing in incidence worldwide, and a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapies using commercially-available drugs, such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD. This review article focuses on effective alternative therapies to improve the prevention and treatment of CKD, using plants or plant extracts. Three mechanistic processes that are well-documented in CKD pathogenesis are inflammation, fibrosis, and oxidative stress. Many plants and their extracts are already known to ameliorate kidney dysfunction through antioxidant action, with subsequent benefits on inflammation and fibrosis. In vitro and in vivo experiments using plant-based therapies for pre-clinical research demonstrate some robust therapeutic benefits. In the CKD clinic, combination treatments of plant extracts with conventional therapies that are seen as relatively successful currently may confer additive or synergistic renoprotective effects. Therefore, the aim of recent research is to identify, rigorously test pre-clinically and clinically, and avoid any toxic outcomes to obtain optimal therapeutic benefit from medicinal plants. This review may prove to be a filtering tool to researchers into complementary and alternative medicines to find out the current trends of using plant-based therapies for the treatment of kidney diseases, including CKD.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-03-04T12:53:47Z
      DOI: 10.1177/2515690X221079688
      Issue No: Vol. 27 (2022)
  • Anti-inflammatory, Analgesic, and Cytotoxic Effects of The Phytexponent: A
           Polyherbal Formulation

    • Authors: Halvince O. Odira, Simon O. Mitema, Isaac M. Mapenay, Gervason A. Moriasi
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      The Phytexponent is used to treat pain and inflammation in complementary and alternative medicine practices; however, empirical data supporting its pharmacological efficacy and safety is scanty, hence the present study. We used the carrageenan-induced paw oedema and the acetic acid-induced writhing techniques to determine the anti-inflammatory and analgesic efficacies, respectively, of the Phytexponent in Swiss albino mice models. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay technique was used to investigate the in vitro cytotoxic effects of the Phytexponent in the Vero E6 cell line. The Phytexponent exerted significant (P 
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-03-01T05:28:11Z
      DOI: 10.1177/2515690X221082986
      Issue No: Vol. 27 (2022)
  • Effects of Slow Deep Breathing on Acute Clinical Pain in Adults: A
           Systematic Review and Meta-Analysis of Randomized Controlled Trials

    • Authors: Amira E. Joseph, Rajat N. Moman, Ross A. Barman, Donald J. Kleppel, Nathan D. Eberhart, Danielle J. Gerberi, M. Hassan Murad, W. Michael Hooten
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Slow deep breathing (SDB) may help patients with acute pain. The primary aim of this systematic review and meta-analysis is to investigate the effects of SDB on acute pain. Secondary aims include investigating the effects of SDB on acute pain-related physical and emotional functioning. An a priori protocol was registered and a database search was conducted by a reference librarian. Randomized controlled trials (RCT) were eligible for inclusion and exclusion criteria included studies of SDB for non-pain indications and studies that applied SDB as a component of an encompassing intervention. The risk or bias was assessed using the Cochrane Collaboration's revised tool for assessing risk of bias in randomized trials. Meta-analysis was conducted using the random effects model. A total of 11 968 studies were screened and seven RCTs met inclusion criteria; five were judged to have low risk of bias. Meta-analysis of post-intervention pain scores demonstrated that SDB was associated with significantly lower pain scores compared with a control group, but with high levels of heterogeneity. Subgroup analyzes demonstrated that trials of burn pain were associated with a larger reduction in pain which partially explains the heterogeneity. Very low certainty evidence suggests that SDB may reduce acute pain intensity. Further research is needed to identify patients who are candidates for SDB and determine the best approach to deliver this therapy.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-02-28T03:53:11Z
      DOI: 10.1177/2515690X221078006
      Issue No: Vol. 27 (2022)
  • Low-dose Oral Thimerosal for the Treatment of Oral Herpes: Clinical Trial
           Results and Improved Outcome After Post-hoc Analysis

    • Authors: Stephen W. Mamber, Thomas Hatch, Craig S. Miller, John V. Murray, Cynthia Strout, John McMichael
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      BackgroundThimerosal (TML) is an organomercury antimicrobial. Low doses (1/250th of the amount in a typical vaccine dose) may promote an antiviral immune response. Low-dose TML (BTL-TML) was evaluated for safety and efficacy against herpes labialis in two FDA-approved, randomized, double blind, placebo-controlled clinical trials.MethodsBTL-TML was evaluated in a Phase IIa trial for its ability to block progression to lesion in subjects with recurrent oral herpes caused by dental trauma. Subjects were administered BTL-TML or a saline control over a 7-day period. In a Phase IIb trial, BTL-TML was evaluated for its ability to block progression to lesion over a 7-day period in subjects with herpes lip infections induced by exposure to ultraviolet (UV) radiation.ResultsProgression to lesion post-dental procedure was prevented in 54.5% (12/22) TML subjects versus 22.2% (2/9) control subjects (p = 0.106). Progression to lesion post-UV irradiation was blocked in 47.8% (11/23) BTL-TML treatment subjects and 42.8% (6/14) control subjects. A post-hoc analysis yielded 52.2% (12/23) BTL-TML subjects with no progression to lesion versus 28.6% (6/21) control subjects with no progression (p = 0.099). There were no significant differences in adverse effects between treatment and control groups in either trial.ConclusionsNeither clinical trial showed a statistically significant effect of BTL-TML on progression to lesion. However, the post-hoc analysis suggested there is a 48-hour period following UV radiation exposure during which the anti-herpes activity of antivirals such as BTL-TML is reduced. Accordingly, BTL-TML may have promise in subsequent, properly designed and powered clinical trials.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-02-10T03:45:20Z
      DOI: 10.1177/2515690X221078004
      Issue No: Vol. 27 (2022)
  • Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian
           Medicinal Plants

    • Authors: Regina Appiah-Opong, Kojo Agyemang, Eunice Dotse, Philip Atchoglo, Kofi Baffour-Awuah Owusu, Abigail Aning, Maxwell Sakyiamah, Richard Adegle, Frederick Ayertey, Alfred Ampomah Appiah, Alexander K. Nyarko
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      Malaria affects about half of the world's population. The sub-Saharan African region is the most affected. Plant natural products have been a major source of antimalarial drugs; the first (quinine) and present (artemisinin) antimalarials are of natural product origin. Some secondary metabolites demonstrate adjuvant antioxidant effects and selective activity. The focus of this study was to investigate the anti-plasmodial activity, cytotoxicities and antioxidant properties of eight (8) Ghanaian medicinal plants. The anti-plasmodial activity was determined using the SYBR green assay and the tetrazolium-based colorimetric assay (MTT) was employed to assess cytotoxicity of extracts to human RBCs and HL-60 cells. Antioxidant potential of plant extracts was evaluated using Folin-Ciocalteu and superoxide dismutase assays. Phytochemical contstituents of the plant extracts were also assessed. All the extracts demonstrated anti-plasmodial activities at concentrations 50% antioxidant effect (SOD). The extracts were not cytotoxicity towards RBCs at the concentration tested (200 μg/ml) but were weakly cytotoxic to HL-60 cell. Selectivity indices of most of the extracts were greater than 10. Our results suggest that most of the plant extracts have strong anti-plasmodial activity and antioxidant activity which warrants further investigations.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-01-17T01:18:43Z
      DOI: 10.1177/2515690X211073709
      Issue No: Vol. 27 (2022)
  • Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions

    • Authors: Tomas Koltai, Larry Fliegel
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6 flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and silychristin. Silybin is functionally the most active of these compounds. This group of flavonoids has been extensively studied and they have been used as hepato-protective substances for the mushroom Amanita phalloides intoxication and mainly chronic liver diseases such as alcoholic cirrhosis and nonalcoholic fatty liver. Hepatitis C progression is not, or slightly, modified by silymarin. Recently, it has also been proposed for SARS COVID-19 infection therapy. The biochemical and molecular mechanisms of action of these substances in cancer are subjects of ongoing research. Paradoxically, many of its identified actions such as antioxidant, promoter of ribosomal synthesis, and mitochondrial membrane stabilization, may seem protumoral at first sight, however, silymarin compounds have clear anticancer effects. Some of them are: decreasing migration through multiple targeting, decreasing hypoxia inducible factor-1α expression, inducing apoptosis in some malignant cells, and inhibiting promitotic signaling among others. Interestingly, the antitumoral activity of silymarin compounds is limited to malignant cells while the nonmalignant cells seem not to be affected. Furthermore, there is a long history of silymarin use in human diseases without toxicity after prolonged administration. The ample distribution and easy accessibility to milk thistle—the source of silymarin compounds, its over the counter availability, the fact that it is a weed, some controversial issues regarding bioavailability, and being a nutraceutical rather than a drug, has somehow led medical professionals to view its anticancer effects with skepticism. This is a fundamental reason why it never achieved bedside status in cancer treatment. However, in spite of all the antitumoral effects, silymarin actually has dual effects and in some cases such as pancreatic cancer it can promote stemness. This review deals with recent investigations to elucidate the molecular actions of this flavonoid in cancer, and to consider the possibility of repurposing it. Particular attention is dedicated to silymarin's dual role in cancer and to some controversies of its real effectiveness.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-01-12T11:58:44Z
      DOI: 10.1177/2515690X211068826
      Issue No: Vol. 27 (2022)
  • A Comparison of Effectiveness of Thai Traditional Massage and Tamsulosin
           in Lower Urinary Tract Symptoms: A Randomized Controlled Trial

    • Authors: Ongart Sinsomboon, Patranuch Noppakulsatit, Adis Tassanarong, Parunkul Tungsukruthai, Kusuma Sriyakul
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      The prospective clinical, non-inferiority study aimed to investigate the effectiveness of Thai traditional massage on lower urinary tract symptoms (LUTS) compared with Tamsulosin in Thai men. It was conducted on men aged 50 to 75 years old with LUTS (N = 45). Participants were blocked four randomly assigned into 2 groups. The control group (n = 25) was received 0.4 mg Tamsulosin daily and the study group (n = 20) was given Thai traditional massage for 4 weeks. The efficacy evaluation was performed by the International Prostate Symptoms Score (IPSS), a Thai version of the World Health Organization Quality of Life Questionnaire (WHO-QoL Brief), Uroflowmetry, and Post-void residual urine (PVR) at baseline and end of study. The background characteristics of participants were not significantly different between groups. Both interventions relieved LUTS in the total IPSS and the quality of life score associated with urination were decreased, described as symptoms and quality of life due to urination improvement after 4 weeks of intervention. Interestingly, the Thai traditional massage has significant improvement in total IPSS and voiding score (p < .05). Additionally, the time to peak flow rate, peak flow rate (Qmax), average flow rate (Qave) and voided volume of both interventions were improved with no statistical significance. PVR was decreased in both interventions. The WHO-QoL brief score was improved the total score. There was no significant difference in terms of uroflowmetry, PVR, and WHO-QoL brief scores compared between groups. The result suggests that Thai traditional massage has the potential to be an alternative treatment for LUTS.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-01-10T01:17:39Z
      DOI: 10.1177/2515690X211068825
      Issue No: Vol. 27 (2022)
  • Vishaghn Dhoop, Nano-Scale Particles with Detoxifying Medicinal Fume,
           Exhibits Robust Anti-Microbial Activities: Implications of Disinfection
           Potentials of a Traditional Ayurvedic Air Sterilization Technique

    • Authors: Acharya Balkrishna, Swami Yagyadev, Swami Vipradev, Kanchan Singh, Yash Varshney, Shubhangi Rastogi, Swati Haldar, Anurag Varshney
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      The rapidly increasing global burden of healthcare associated infections (HAI) is resulting in proportionate increase in chemical disinfection in healthcare settings, adding an extra burden of environmental toxicity. Therefore, alternative disinfection techniques with less or no adverse side-effects need to be explored. In this regard, ayurvedic ‘dhoopan’ technique involving slow combustion of medicinal herbs, minerals and animal products hold great promise. In this study, dhoopan of a traditionally defined ayurvedic medicinal mix, ‘Vishaghn Dhoop’ (VD) has been assessed for its anti-microbial potentials against both Gram-positive and negative pathogenic bacteria, Mycobacterium and pathogenic fungus, Candida albicans. Fume generated from slow combustion of VD was subjected to physico-chemical characterization and was assessed for anti-microbial effects. VD fume contained particles of 354 ± 84 nm size, laden with anti-microbial metabolites. On agar plates, VD fumigation reduced bacterial growth by 13 - 38%. Liquid culture aeration with VD fume inhibited bacterial growth by 50 - 85%, and fungal growth by 80%. In real life settings (in vivo), un-sanitized rooms fumigated with VD fumes for 30 min reduced the environmental microbial loads by 10 folds. In addition, the safety of VD fumigation was evaluated through in vitro cytotoxicity assay on human lung epithelial (A549) cells. Cells exposed to media-collected VD fumes for 24 h exhibited normal cyto-safety profile. Collectively, these observations provide scientific evidence in support of a traditional technique of disinfection, which can be fine-tuned to have implications in clinical, healthcare and food industry where, disinfection is a prime requirement.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-01-05T02:41:30Z
      DOI: 10.1177/2515690X211068832
      Issue No: Vol. 27 (2022)
  • COVID-19: General Strategies for Herbal Therapies

    • Authors: Samaneh Soleymani, Ayeh Naghizadeh, Mehrdad Karimi, Azadeh Zarei, Raefeh Mardi, Gholamreza Kordafshari, Niusha Esmaealzadeh, Arman Zargaran
      Abstract: Journal of Evidence-Based Integrative Medicine, Volume 27, Issue , January-December 2022.
      The coronavirus disease-2019 (COVID-19) pandemic started in early 2020 with the outbreak of a highly pathogenic human coronavirus. The world is facing a challenge and there is a pressing need for efficient drugs. Plants and natural compounds are a proven rich resource for new drug discovery. Considering the potential of natural products to manage the pandemic, this article was designed to provide an inclusive map of the stages and pathogenetic mechanisms for effective natural products on COVID-19. New drug discovery for the COVID-19 pandemic can encompass both prevention and disease management strategies. Preventive mechanisms that may be considered include boosting the immune response and hand hygiene in the preexposure phase; and blocking of virus binding and entry in the postexposure phase. Potential therapeutic target mechanisms include virus-directed therapies and host-directed therapies. Several medicinal plants and natural products, such as Withania somnifera (L.) Dunal and propolis for prevention; Tanacetum parthenium (L.) for treatment; and Ammoides verticillata (Desf.) Briq and Nigella sativa L. for both prevention and treatment have been found effective and are good targets for future research. The examples of phytochemical compounds that may be effective include aloin and terpenes as anti-septics; isothymol, dithymoquinone, and glycyrrhizin as inhibitors of virus binding and entry; glycyrrhizin, and berberine as replication suppressants; ginsenoside Rg1 and parthenolide as immunomodulators; and eriocitrin, rhoifolin, hesperidin, naringin, rutin, and veronicastroside as anti-complements. Recognizing different mechanisms of fighting against this virus can lead to a more systematic approach in finding natural products and medicinal plants for COVID-19 prevention and treatment.
      Citation: Journal of Evidence-Based Integrative Medicine
      PubDate: 2022-01-05T02:41:10Z
      DOI: 10.1177/2515690X211053641
      Issue No: Vol. 27 (2022)
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