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- Aesthetic Radiofrequency Associated with Rosmarinus officinalis
Supplementation is Safe and Reduces Oxidative Stress in Women: Randomized,
and Double-Blind Clinical Trial
Authors: Greissi Tatieli Franke Tremêa, Karine Raquel Uhdich Kleibert, Lenara Schalanski Krause, Ana Paula Weber Fell, Anais Regina Scapini, Keli Wilchen Marschall, Cristiano Sartori Baiotto, Martha Héllen Tremêa da Silva, José Antonio Gonzalez da Silva, Christiane de Fátima Colet
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
The objective were to evaluate the effects of supplementation of standardized dry extract of Rosmarinus officinalis (RO) and the application of aesthetic radiofrequency on the oxidative stress markers catalase (CAT), superoxide dismutase (SOD), non-protein thiols (NP-SH), and thiobarbituric acid reactive species (TBARS) and the biochemical markers triglycerides, total cholesterol, high density lipoprotein (HDL) cholesterol, glutamic-oxaloacetic transaminase (TGO/AST), pyruvic-glutamic transaminase (TGP/ALT), gamma glutamyl transpeptidase (gamma-GT), and creatinine. This study included 32 women received the aesthetic therapy to reduce localized fat. They were divided into the control group (n = 8) receiving placebo capsules and the intervention group (n = 24) subdivided into Group A, B, and C, each with eight members receiving supplementation with 100, 500, and 1000 mg/day of standardized dry extract of RO, respectively. The Universal Trial Number (UTN) – U1111-1274-6255. Supplementation with RO (500 mg/day) demonstrated a reduction in oxidative stress (quantified with through a significant increase in NP-SH and a reduction in SOD and CAT enzymes). The radiofrequency aesthetic treatment did not promote an increase in oxidative stress; however, it caused significant changes in total cholesterol, HDL cholesterol, and creatinine. RO is a plant with antioxidant effects and its oral consumption is safe in selected women subjects in hepatic and renal markers.
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-08-13T06:19:47Z
DOI: 10.1177/2515690X241246293
Issue No: Vol. 29 (2024)
- Characterization of Antibiofilm and Antimicrobial Effects of Trigona
Stingless Bee Honey Compared to Stinging Bee Centaurea hyalolepis and
Citrus Honeys
Authors: Walid Salem Aburayyan, Nesrin Seder, O’la Al-fawares, AbdulFattah Fararjeh, Ibrahim S. Majali, Yousef Al-Hajaya
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
The antibiofilm and antimicrobial properties of tropical honey types including Malaysian stingless bee honey remain explicitly unexplored when compared with Apies honey. The antibiofilm and antimicrobial activities of the Malaysian Trigona honey were characterized with two stinging bee honey types (Centaurea hyalolepis and Citrus honeys) from Jordan. The antibiofilm and antimicrobial investigations were conducted on a set of seven microbial strains; five bacterial species of Pseudomonas aeruginosa ATCC 10145, Streptococcus pyogenes ATCC 19615, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and two fungal strains Candida albicans ATCC 10231 and Candida krusei ATCC 14243. The antimicrobial investigations revealed a broad spectrum activity for Trigona honey against Gram-positive, Gram-negative, and fungal strains over the two honey types. One-way ANOVA showed a significant difference (p
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-08-09T07:56:18Z
DOI: 10.1177/2515690X241271978
Issue No: Vol. 29 (2024)
- Phytolacca Dodecandra (L’ Herit) (Phytolaccaceae) Methanol Root Extract
Protects Liver from Acetaminophen-Induced Injury in Rats
Authors: Gudeta Duga Geresu, Tilahun Tesfaye Abebe, Diriba Alemayehu Gadisa, Getu Melese Taye, Dejene Hailu Bedada, Tamirat Bekele Baressa, Shemsu Umer Hussen, Tesemma Sileshi Chala
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
Phytolacca dodecandra (L’ Herit), or ‘Endod’, is one of the widely known medicinal plants in Ethiopia. Berries of the endod have been used as a detergent for centuries. The present study was aimed to test the hepatoprotective effects of the plant against acetaminophen (APAP)-induced liver injury in rats. Mice of either sex were used for oral acute toxicity tests and APAP-induced lethality tests. Hepatoprotective experiments were done on male rats using 2 g/kg of APAP to induce liver damage. Liver enzymes, total bilirubin (TB), and lipid profile were determined. Liver tissues were also examined histopathologically to see a morphologic change in the control and experiment groups. The protective effect of the plant extract was also tested through sodium pentobarbital (SPB)-induced sleeping time. A significant increase in serum levels of liver enzymes, TB, low-density lipoprotein (LDL), and triglycerides (TGs) was seen from oral administration of 2 g/kg APAP. Total cholesterol (TC) and high-density lipoprotein (HDL) levels were decreased. Serum levels of all parameters were reversed to normal after administration of silymarin 100 mg/kg and, 100, 200, and 400 mg/kg doses of the extract. A significant dose-dependent hepatoprotective effect of Phytolacca dodecandra Methanol Root Extract (PDME) was seen in terms of LDL. Histopathological investigations and SPB-induced sleeping time confirmed the findings of biochemical analysis. The findings of the present study indicate that PDME protected the liver from APAP injury.
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-07-25T11:25:37Z
DOI: 10.1177/2515690X241263063
Issue No: Vol. 29 (2024)
- Alkalinization Using Sodium Bicarbonate for COVID-19 Treatment: A
Systematic Review and Meta-Analysis
Authors: Arman Shafiee, Kyana Jafarabady, Hassan Moltazemi, Mohammad Javad Amini, Mohammad Ali Rafiei, Amirhossein Akhondi, Sayed-Hamidreza Mozhgani
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
BackgroundA systematic review and meta-analysis have been conducted to evaluate the efficacy of alkalinization for COVID-19 patients based on current evidence to determine the impact of alkalinization on COVID-19 outcomes.MethodsWe searched MEDLINE (Pubmed), Web of Science, Cochrane Library, and Clinicaltrials.gov for studies evaluating the efficacy of alkalinization up to 30 April 2023. Based on the PRISMA 2020 statement criteria a systematic review and meta-analysis of studies were performed.ResultsThe results of our meta-analysis showed a significant reduction in mortality rate in the alkalinization group compared to controls (RR 0.73, 95% CI: 0.56-0.95; I2 = 0%). However, our subgroup analysis showed no significant improvement in RCT-only studies (RR 0.78, 95% CI: 0.59-1.05; I2 = 0%), the recovery rate was significantly higher in the alkalinization group (RR 2.13, 95% CI: 1.39-3.26; I2 = 0%), duration of recovery also has improved in alkalinization group (SMD 0.76, 95% CI: 0.33-1.18; I2 = 0%). The results of our meta-analysis showed a significant reduction in the duration of hospitalization in the alkalinization group compared to controls with very low certainty of evidence (SMD −0.66, 95% CI: −0.97 to −0.35; I2 = 36%).ConclusionWith low certainty of evidence, alkalinization (by sodium bicarbonate) can be an efficient and safe adjuvant treatment for COVID-19 patients. Future randomized controlled trials are needed to strengthen the available evidence.
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-06-03T07:02:08Z
DOI: 10.1177/2515690X241258403
Issue No: Vol. 29 (2024)
- A Combination of Curcumin and Lactobacillus rhamnosus GG Inhibits
Viability and Induces Apoptosis in SCC-9 Human Oral Squamous Cell
Carcinoma Cells
Authors: Chatchaphan Udompatanakorn, Panan Ratthawongjirakul
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
The aim of this study was to evaluate the effect of curcumin combined with Lactobacillus rhamnosus GG cell-free supernatant (LGG CFS) on the proliferation and induction of apoptosis in SCC-9 oral squamous cell carcinoma (OSCC) cells. Curcumin (40 µg/ml) and 25% v/v LGG CFS (108 CFU/ml), both alone and in a combination regimen, significantly decreased the viability of SCC-9 cells and normal human gingival fibroblast (HGF) cells. Interestingly, the combination of low doses of curcumin (5 µg/ml) and 25% v/v LGG CFS (106 CFU/ml) had no effect on the HGF cells but significantly inhibited the viability of SCC-9 cells (p
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-05-23T07:05:18Z
DOI: 10.1177/2515690X241258369
Issue No: Vol. 29 (2024)
- In Vivo Anti-Hepatocellular Carcinoma Effects of the Chloroform Root
Extract of Clausena excavata Burm
Authors: Peter Waziri, Richard Auta, Mustapha U Imam, Ben A Chindo, Zakari Ladan, Zainab Mohammed, Samson Wayah, Ja'afar Mohammed, Mohammed I Tahir, Abdurrahman E Ahmad, Yusuf Alhassan, Daniel Tyoapine, Abel S Agbaji
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
Liver cancer is the most common cancer among males in Africa. The disease has a poor prognosis and its treatment is associated with toxicity and resistance. For this reason, numerous herbal combinations are being subjected to anticancer screening to circumvent the shortcomings of the conventional anticancer drugs. In the current study, the in vivo anti-cancer effects of the chloroform root extract of the herb, Clausena excavata Burm were investigated. Liver cancer was induced in mice by a single intraperitoneal injection of diethylnitrosamine (DEN) followed by oral administration of the promoter of carcinogenesis, 2-aminoacetyl fluorine that was mixed with the mice feed. The cytotoxicity of the root extract of C. excavata on liver cancer cells was investigated using liver enzyme, histology, DNA fragmentation and caspases assays. Real time qPCR was conducted to evaluate the effect of the extract on apoptotic genes. The findings revealed that the extract of C. excavata significantly decreased the progression of hepatocarcinogenesis and the toxicity-induced production of the liver enzymes, alanine and aspartate aminotransferases. The histological analyses of the liver tissues revealed evidence of apoptotic cell death. The extract also provoked significant (p
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-05-01T05:26:29Z
DOI: 10.1177/2515690X241251558
Issue No: Vol. 29 (2024)
- Effect of Aqueous Extract of Unripe Musa Paradisiaca Linn on Parameters
Affecting Reproduction in Rats
Authors: Collins Azubuike Onyeto, Akachukwu Marytheresa Onwuka, Ikechukwu Emmanuel Peter, Chukwuemeka Sylvester Nworu, Peter Achunike Akah
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
ObjectiveAqueous extract of unripe Musa paradisiaca fruit is commonly used for the treatment of ulcers in eastern Nigeria. This study aimed to assess the acute and subacute effects of an aqueous extract of unripe fruit on male and female fertility in rats.MethodsAqueous extracts obtained by maceration were analyzed for acute and subacute toxicity and for the presence of phytochemical constituents using standard procedures. The extract (100, 500, and 1000 mg/kg) was administered daily to rats of both sexes for 28 d. Blood samples collected on days 0 and 28 were assessed for follicle-stimulating hormone (FSH), luteinizing hormone (LH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA). Testes and ovaries were harvested for histopathological analysis. Sperm were also collected to determine the sperm count and motility.ResultsPhytochemical screening revealed the presence of saponins, tannins, alkaloids, and resins. After an oral dose of up to 5000 mg/kg, there were no deaths in the acute toxicity test. The extract (500 mg/kg) significantly (P
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-04-29T02:29:56Z
DOI: 10.1177/2515690X241249534
Issue No: Vol. 29 (2024)
- Garcinia dulcis Extract Alleviates Inflammation in Kidney and Liver of the
2-Kidney-1-Clip Hypertensive rat
Authors: Nattaya Thongsepee, Wanwisa Himakhun, Ratsikan Parachat, Pongsakorn Martviset, Pathanin Chantree, Phornphan Sornchuer, Kant Sangpairoj, Siriphun Hiranyachattada
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
Garcinia dulcis (GD) extract possesses anti-hypertensive property that are poorly characterized. This study aimed to investigate an anti-inflammatory effect of GD flower extract in the 2-kidney-1-clip (2K1C) hypertensive compared to sham operative (SO) rat. Male Wistar rats were divided into 2 groups; the 2K1C group in which a silver clip was placed around renal artery to induce hypertension, and the SO normotensive group. Four weeks later, each group of rats were further divided into 2 subgroups, each subgroup was orally gavaged of either corn oil (vehicle) or 50 mg/kg BW GD extract daily for 4 weeks. The malondialdehyde (MDA) levels in serum, liver, and kidney were determined. Hematoxylin and eosin staining was carried out for histological examination, Periodic acid – Schiff staining for glomerular injury, Masson's trichrome staining for renal fibrosis, and immunohistochemistry for either tumor necrosis factor alpha (TNF-α) or endothelial nitric oxide synthase (eNOS) investigation. Taken together, our results demonstrated that GD flower extract decreased the MDA level in both serum and liver and kidney tissue and suppressed the expression of TNF-α in both liver and kidney of 2K1C hypertensive rats. Mesangial cell proliferation, expansion of mesangial matrix, widening Bowman's capsule space, congestion of glomerular capillary and vessel, cloudy swelling of renal tubular epithelial cell, and renal fibrosis were observed in the kidneys of 2K1C rats. Therefore, we concluded that GD flower extract can alleviate liver and kidney inflammation in which partially attenuates the glomerular injury in the 2K1C rat.
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-04-13T09:27:54Z
DOI: 10.1177/2515690X241244845
Issue No: Vol. 29 (2024)
- Objective Evaluation of Pulse Width Using an Array Pulse Diagram
Authors: Zi-Juan Bi, Ji Cui, Xing-Hua Yao, Xiao-Juan Hu, Si-Han Wang, Meng-Chen Liang, Zhi-Hui Zhou, Jia-Tuo Xu
Abstract: Journal of Evidence-Based Integrative Medicine, Volume 29, Issue , January-December 2024.
BackgroundPulse width, which can reflect qi, blood excess, and deficiency, has been used for diagnosing diseases and determining the prognosis in traditional Chinese medicine (TCM). This study aimed to devise an objective method to measure the pulse width based on an array pulse diagram for objective diagnosis.MethodsThe channel 6, the region wherein the pulse wave signal is the strongest, is located in the middle of the pulse sensor array and at the guan position of cunkou during data collection. Therefore, the main wave (h1) time of the pulse wave was collected from the channel 6 through calculation. The left h1 time was collected from the remaining 11 channels. The amplitudes at these time points were extracted as the h1 amplitudes for each channel. However, the pulse width could not be calculated accurately at 12 points. Consequently, a bioharmonic spline interpolation algorithm was used to interpolate the h1 amplitude data obtained from the horizontal and vertical points, yielding 651 (31 × 21) h1 amplitude data. The 651 data points were converted into a heat map to intuitively calculate the pulse width. The pulse width was calculated by multiplying the number of grids on the vertical axis with the unit length of the grid. The pulse width was determined by TCM doctors to verify the pulse width measurement accuracy. Meanwhile, a color Doppler ultrasound examination of the volunteers’ radial arteries was performed and the intravascular meridian widths of the radial artery compared with the calculated pulse widths to determine the reliability.ResultsThe pulse width determined using the maximal h1 amplitude method was comparable with the radial artery intravascular meridian widths measured using color Doppler ultrasound. The h1 amplitude was higher in the high blood pressure group and the pulse width was greater.ConclusionsThe pulse width determined using the maximal h1 amplitude was objective and accurate. Comparison between the pulse widths of the normal and high blood pressure groups verified the reliability of the method.
Citation: Journal of Evidence-Based Integrative Medicine
PubDate: 2024-03-28T07:39:40Z
DOI: 10.1177/2515690X241241859
Issue No: Vol. 29 (2024)
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