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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
Showing 1 - 15 of 15 Journals sorted alphabetically
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Acupuncture in Medicine     Hybrid Journal   (Followers: 16)
Advanced Herbal Medicine     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 3)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
Alternative & Integrative Medicine     Open Access   (Followers: 10)
Alternative Medicine     Full-text available via subscription   (Followers: 2)
Alternative Medicine Studies     Open Access   (Followers: 6)
Anales de Hidrología Médica     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 3)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 3)
Asian Journal of Plant Pathology     Open Access   (Followers: 4)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 2)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 9)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 4)
BMC Complementary Medicine and Therapies     Open Access   (Followers: 17)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine     Open Access   (Followers: 3)
Chinese Medicine and Culture     Open Access   (Followers: 1)
Cognitive Neuroscience     Hybrid Journal   (Followers: 31)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 18)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 16)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 2)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 22)
Experimental and Therapeutic Medicine     Full-text available via subscription  
Fitoterapia     Hybrid Journal   (Followers: 4)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 11)
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access  
Global Journal of Traditional Medicine     Open Access  
Herba Polonica     Open Access  
Herbal Medicines Journal     Open Access   (Followers: 1)
Indian Journal of Ayurveda and lntegrative Medicine Klue     Open Access   (Followers: 3)
Indian Journal of Research in Homoeopathy     Open Access  
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 1)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 2)
Intas Polivet     Full-text available via subscription  
Integrative Medicine Research     Open Access   (Followers: 3)
International Journal of High Dilution Research     Open Access  
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
International Journal of Yoga     Open Access   (Followers: 15)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Ipnosi     Full-text available via subscription  
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 14)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 1)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Journal of Ayurveda     Open Access   (Followers: 3)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 6)
Journal of Ayurveda Case Reports     Open Access   (Followers: 3)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 7)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 16)
Journal of Complementary and Alternative Medical Research     Open Access  
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 10)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 3)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
Journal of Fasting and Health     Open Access   (Followers: 1)
Journal of Ginseng Research     Open Access  
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Journal of Health Sciences Scholarship     Open Access  
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access  
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 2)
Journal of Integrative Medicine & Therapy     Open Access  
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Palliative Medicine     Hybrid Journal   (Followers: 51)
Journal of Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription  
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 3)
Journal of Traditional Chinese Medical Sciences     Open Access  
Médecine Palliative     Full-text available via subscription   (Followers: 1)
Medical Acupuncture     Hybrid Journal   (Followers: 5)
Medicines     Open Access   (Followers: 1)
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Muller Journal of Medical Sciences and Research     Open Access   (Followers: 1)
Natural solutions     Full-text available via subscription  
Natural Volatiles & Essential Oils     Open Access  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
OA Alternative Medicine     Open Access  
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Research Journal of Pharmacognosy     Open Access  
Revista Internacional de Acupuntura     Full-text available via subscription  
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Synfacts     Hybrid Journal   (Followers: 5)
Traditional & Kampo Medicine     Full-text available via subscription  
Traditional Medicine Journal     Open Access  
World Journal of Acupuncture - Moxibustion     Full-text available via subscription  
World Journal of Traditional Chinese Medicine     Open Access  
Yoga Mimamsa     Open Access   (Followers: 2)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 1)

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International Journal of High Dilution Research
Journal Prestige (SJR): 0.186
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1982-6206
Published by Universidade Estadual Paulista Homepage  [10 journals]
  • Proceedings of the XXXIV GIRI meeting and V International Workshop on
           Homeopathy

    • Authors: Carla Holandino, Vânia Emerich Bucco , Maria Olga Kokornaczyk
      Pages: 01 - 01
      Abstract: The XXXIV annual GIRI Meeting was held for the first time together with the V International Workshop on Homeopathy (IWH) in frames of an academic-scientific partnership between the Brazilian Public University (Universidade Federal do Rio de Janeiro, UFRJ) and the GIRI society (International Research Group on Very Low Dose and High Dilution Effects). This event occurred on December 2nd to 4th 2021 as online conference. Thanks to the partnership as well as the use of the virtual platform, the GIRI meeting 2021 reached the highest visibility in the whole history of already 34 meetings (there were ca. 600 inscriptions and more than 14 000 page views on the last conference day). At the meeting 12 abstracts were presented as oral contributions and further 34 as e-posters. The 5th Edition of International Workshop on Homeopathy regarded “The scientific evidence of homeopathy in health care” and provided the possibilities to exchange scientific experiences, to discuss many research details, and to meet other researchers involved into basic and clinical homeopathic research from all over the world. The scientific sections were dedicated to the following subjects:
      Homeopathy teaching and practice;
      Chemical and physical models;
      In vivo and in vitro models;
      Clinical trials. We are convinced that the content of the present special issue of the International Journal High Dilution Research dedicated to the memories of XXXIV GIRI meeting will bring new insights to the homeopathic scientific community.  
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1226
      Issue No: Vol. 21, No. 1 (2022)
       
  • A fresh look at the concept of Genus Epidemicus: findings from the
           Clificol Project

    • Authors: Alexander Tournier, Yvonne Fok , Robert van Haselen
      Pages: 02 - 02
      Abstract: Background: The Clificol® COVID-19 Support Project is an innovative international data collection project aimed at tackling some of the core questions in homeopathy, including the notion of Genus Epidemicus. Aims: To shed some light on the notion of Genus Epidemicus in the context of this infection. Going beyond that, the project aims to use these data to tackle more fundamental questions, such as the role of symptoms and rubrics in treatment individualisation. Methodology: This online multi-national data-collection project is supported by the ECH, ECCH, ICH, HRI, LMHI, and other professional associations. The collected data includes demographic information, severity, conventional diagnosis and treatment, presenting symptoms as well as the remedies prescribed. The outcome of treatment was tracked using the ORIDL scale. The concept of Genus Epidemicus, including the role of treatment individualisation, was investigated by analysing whether presenting symptoms cluster into distinct groups (K-Means clustering approach). The symptom data originating from China was obtained using a questionnaire. Results and discussion: 20 Chinese practioners collected 359 cases, primarily in the first half of 2020 (766 consultations, 363 prescriptions). The cluster analysis found two to be the optimum number of clusters. These two symptomatic clusters had a high overlap with the two most commonly prescribed remedies in that population: In cluster 1 there were 297 prescriptions, 95.6% of which were Gelsemium sempervirens, In cluster 2, there were 61 prescriptions, 95.1% of which were Bryonia alba. Under the assumption of a single genus epidemicus we would expect to see a single cluster of symptoms. The data from the Chinese population were not compatible with this assumption. Conclusion: This was the first study that investigated the notion of Genus Epidemicus by using modern statistical techniques. These analyses identified at least two distinct symptom pictures. The notion of a single COVID-19 Genus Epidemicus did not apply to this population.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1158
      Issue No: Vol. 21, No. 1 (2022)
       
  • Carcinosinum produces phenotypic changes of 4T1 tumor cells in vitro

    • Authors: Thaís Cristina Silva, William Alves Santos, Sandra Augusta Gordinho Pinto, Elizabeth Cristina Perez Hurtado, Leoni Villano Bonamin
      Pages: 03 - 03
      Abstract: Considering that there are few published studies that specifically address the exclusive use of Carcinosinum in different potencies and, most of them focused on genotypic and clinical effects, the present study was proposed to identify possible phenotypic changes, including viability, expression of HER-2 and metastatic abilities, using 4T1 cells in vitro as a model. Carcinosinum was tested in different homeopathic potencies (12cH; 30cH; 200cH) mechanically prepared using sterile pure water. The time space between preparing the potencies and using them was 24 hours.The final dilutions were inserted into the culture medium in a volume equal to 10%, at the time of cell seeding. The same succussed vehicle used to prepare the drugs (70% ethanol) diluted 1:100 in sterile pure water was used as control. All treated cells were cultured in 25 mL flasks, with cell density of 5 x 105 cells/mL. After 24 hours of treatment, cells were analyzed for apoptosis index using Annexin V kit and the Countess® system. The morphology of 4T1 cells was monitored by staining cell smears with hematoxylin-eosin and Giemsa methods. HER-2 expression was assessed by immunocytochemistry and metalloproteinase activity was assessed by zymography. The determination of the cytokine profile was performed using Cytometric Bead Array (CBA). The samples were evaluated in quadruplicate and the data were analyzed by one-way ANOVA. Carcinosinum 30cH presented the highest apoptotic index and reduction of MMP-9-Pro expression; Carcinosinum 200cH produced the highest positivity for HER-2 and no specific effect was seen after the treatment with Carcinosinum 12cH. No change in cytokine expression was seen among treatments. We conclude that Carcinosinum 30cH and 200cH can change phenotypic features important to tumor development in vitro. The clinical meaning of these data deserves further investigation.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1196
      Issue No: Vol. 21, No. 1 (2022)
       
  • Characterization of physicochemical markers for homeopathic medicines and
           biological supernatant samples

    • Authors: Sandra Augusta Gordinho Pinto, Ana Carla Aparicio, Jefferson Souza, Ivana Suffredini, Steven Cartwright, Leoni Bonamin
      Pages: 04 - 04
      Abstract: Introduction: Solvatochromic dyes are probes to detect variations on the dipole moment of solvents after the insertion of homeopathic potencies. Recent studies have shown they can be useful tools in laboratory and field studies to detect the activity of homeopathic remedies. Objective: Determine whether solvatochromic dyes can be a diagnostic tool for cells infected by different agents and/or markers to identify the activity of homeopathic medicines. Methods: Ethilicum 1cH, Silicea terra 6, 30, 200cH; Zincum metallicum 6, 30, 200cH and Phosphorus 6, 30 and 200cH were analyzed by pouring the samples (in a 1:60 rate) into a series of seven dyes (rhodamine, ET 33, ET 30, coumarin 7, NN DMIA, Nile red, methylene violet) diluted in absolute ethanol using pre-established working concentrations. Oscillations of dye absorbance were observed at visible light spectrophotometry according to the remedy and potency. Water and succussed water were used as controls. In a second moment, the absorbance profile of the remedies will be compared with those of biological samples (supernatants) and checked with the biological effect previously obtained from each treatment. Supernatants of RAW 264.7 macrophages stimulated by Calmette-Guérin bacilli (BCG) or infected with Encephalitozoon cuniculi will be analyzed. Results: Preliminary results have shown that Silicea terra 6cH, Phosphorus 30 and 200cH and Zincum metallicum 6, 30 and 200cH reduced the absorbance of methylene violet (p=0.01). Repetitions and analysis of supernatants are expected to be performed in the next steps of the study. Future perspectives: Establish a pattern of reactivity of the studied medicines with different dyes and the putative relation with the corresponding supernatants, as an attempt to obtain a “physicochemical signature” for each kind of infection and/or treatment.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1166
      Issue No: Vol. 21, No. 1 (2022)
       
  • Comparative analysis for quality control of mother tinctures in Brazilian
           reports

    • Authors: Vânia Emerich Bucco Campos, Hayla da Silva Pinheiro, Andréa Durão Neves, Gleyce Moreno Barbosa
      Pages: 05 - 05
      Abstract: Background: Quality control of a homeopathic mother tincture begins with the analysis of the raw material. Once the product is obtained, some organoleptic characteristics and Physicochemical properties such as appearance, colour, odour, density, dry residue, alcohol content, and chemical marker are evaluated. In Brazil, mother tinctures from different suppliers may have high variability in terms of the specifications described in the homeopathic pharmacopoeia. Objective: The aim of the present study was to compare mother tinctures’ quality control from different pharmaceutical suppliers based on Brazilian Homeopathic Pharmacopoeia 3rd edition. Methods: Five mother tinctures were selected according to the high number of requests in the pharmacies, also its monographs are in the Brazilian Homeopathic Pharmacopoeia (FHB) 3rd edition. The report of analysis of the product was provided by three homeopathic pharmacies from the city of Rio de Janeiro. The information in the reports was evaluated and compared to its monograph. Results and discussion: In this study, it was found that the number of laboratories that provide homeopathic pharmaceutical ingredients is rather low. In addition, in some reports, a number of identification tests were not described properly when compared to the monograph. Besides that, some information diverges from the pharmacopoeia, for example, absence of dry residue testing, replacement of the part of the plant used to prepare the mother tincture, and results that do not meet pharmacopoeia specifications. As can be seen, the quality and effectiveness of homeopathic medicines prepared from these tinctures may be compromised. Conclusion: In order to guarantee consumer protection and the quality and effectiveness of medicines, governments and regulatory agencies should require a greater commitment from suppliers in the production of homeopathic inputs.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1167
      Issue No: Vol. 21, No. 1 (2022)
       
  • Control of Rhipicephalus microplus ticks in dairy cattle using homeopathic
           therapy

    • Authors: Mônica Filomena Assis Souza, Lucas Seikichi Nascimento Oshiro, Elton Bock Correa, Marco Antonio Cucco, Pedro Henrique de Souza ucco, Raquel Soares Juliano, Karine Bonucielli Brum
      Pages: 06 - 06
      Abstract: Background: The negative impact of Rhipicephalus microplus infestations on cattle farming is well-known. The main control method is the use of ixodicides, which have as side effects environmental contamination, the selection of resistant lineages, and toxicity. Their use is also prohibited in systems that produce organic and agroecological food. Such factors reinforce the importance of strengthening research related to the application of homeopathic principles in animal production. Aim: In this setting, this work aimed at assessing the efficacy of the homeopathic therapy to control Rhipicephalus microplus ticks in dairy cattle. Methodology: 63 crossbred and Girolando breed cows, 1 and 9 years of age, naturally infested by ticks and created under a semi-intensive system in three farms (1, 2, and 3) were assayed. The animals were divided into three control groups and three treated groups, using the drug product EndectoSigo® (Psorinum 12 CH, Sulphur 12CH, Ledum palustre 12 CH, Cina 12 CH e Apis mell. 7CH) at a dose of 10 g/animal/day added to mineral and/or food supplement. The visual counting of teleogines with the size equal to or higher than four millimeters in diameter was performed in the neck or udder area of the animal. Pluviometry and registration of ixodicide baths were performed as well. The means obtained were compared by using ANOVA test and Tukey’s test. Results: The mean number of teleogines on farm 1 was significantly lower (p<0.05) in the treatment group. As for farms 2 and 3, there was no statistical difference between the groups (treated and control); however, it was observed that two ixodicide baths were required in the control group (farm 2). The pluviometry did not interfere with the manifestation. Conclusion: It was concluded that the homeopathic treatment has the efficacy required to control this tick in cattle and can be an alternative to the use of chemical ixodicides.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1168
      Issue No: Vol. 21, No. 1 (2022)
       
  • Effect of homeopathy on quality of corncobs naturally exposed to sugarcane
           virus

    • Authors: Mônica Filomena Assis Souza, Kácio Gomes Macedo, David Junior de Oliveira Pereira, Graciela Andreia Flis Machado, Leonardo Américo Souza Barbosa, Larissa Wolff Gonçalves, ²; Pedro Henrique de Souza Cucco, Marco Antonio Cucco, Karine Bonucielli Brum
      Pages: 07 - 07
      Abstract: Background: The use of pesticides is damaging to the health of farmers and consumers as their use is associated with numerous diseases. Homeopathy is one of the techniques for organic agriculture currently authorized by the MAPA. Aims: To assess the effect of homeopathic compounds on corncob quality in pesticide-free cultures. Methodology: The experiment was performed in, MS-Brazil. Two culture fields were used, each 30m2in size. The homeopathic group treatment consisted of 1ml of30% hydroalcoholic solution with homeopathic ingredients. This solution was diluted into 30ml of water and then sprayed onto 100 seeds. The control group was submitted to the same protocol excluding the homeopathic ingredients. The homeopathic ingredients used were Sulph9C, Mag-c 12C, and Calc-p9C, prescribed according to Materia Medica instructions. The evaluation was performed at harvest by comparing the average weight of 1000 kernels per group, obtained from a weighing of 3000 kernels per group. In addition, a number of corncobs from both groups were qualitatively evaluated as “good” or “bad.” Statistics analysis used the T-test to compare the kernel weight averages and Fisher’s exact test to analyze the corncob quality frequency. Both groups were naturally infected by a virus from a neighboring sugarcane field, causing qualitative and quantitative losses on both groups. Results and discussion: The average weight of 1000 kernels from the treated group (329 g) was not significantly greater (p=0.06) than the average weight of 1000 kernels from the non-treated group (308 g). It was observed that 71out of 158 (44.9%) corncobs from the homeopathic treatment group were classified as “good” while zero out of 50 (0%) corncobs from the non-treated group were classified as “good”, resulting in a significant difference (p<0.01). Conclusion: Homeopathic compounds can be used as a feasible treatment for health and productivity in the corn crop.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1169
      Issue No: Vol. 21, No. 1 (2022)
       
  • Effect of homeopathy on soybean germination through soil and seed
           treatment

    • Authors: Mônica Filomena Assis Souza, Kácio Gomes Macedo, David Junior de Oliveira Pereira, Graciela Andreia Flis Machado, Leonardo Américo Souza Barbosa, Larissa Wolff Gonçalves, Pedro Henrique de Souza Cucco, Marco Antonio Cucco, Karine Bonucielli Brum
      Pages: 08 - 08
      Abstract: Background: Homeopathy is a technique approved by the MAPA for organic production systems. Experiments demonstrating the effectiveness of homeopathy in agriculture are essential. Aims: To evaluate the effects of homeopathic treatment on soybean seed germination. Methodology: The experiment was performed in MS-Brazil. An area of 70 m² was used, divided into two comparison plots of 30 m² each. The soil of plot 1 (treated group) was treated with 5.25 kg of powdered Lithothamnium mixed with 250 ml of 30% hydroalcoholic solution (HS) containing homeopathic ingredients. The soil of plot 2 (control group) was treated with the same preparation but without homeopathic ingredients. Additionally, the 400 seeds assigned toplot 1 were treated with 0,3 ml of a solution made up of 10 ml of 30% HS with homeopathic ingredients diluted in 300 ml of water. The 400 seeds assigned toplot 2 were treated with 0.3 ml of a solution made up of 10 ml of HS without homeopathic ingredients diluted in 300 ml of water. The homeopathic ingredients Sulph 9C, Mag-c 12C, and Calc-p 9C were used on soil and seed treatment. The selection and prescription of those ingredients followed Materia Medica instructions. The experiment was conducted using randomized design and 400 seeds per group were sown. Results and discussion: In plot 1, an average of 11 seeds per m² germinated, adding up to 330 germinated seeds at a percentage of 82.5%. In plot 2, an average of 7 seeds per m² germinated, adding up to 210 germinated seeds at a percentage of 52.5%. The frequency of seed germination in both groups was assessed by the Chi-square test to check for significant differences (p<0.05). There was a statistical difference (p<0.05) in the seed germination in the treated group (n=330) compared to the control group (n=210). Conclusion: Homeopathic compounds can be used as a viable treatment for soybean germination.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1170
      Issue No: Vol. 21, No. 1 (2022)
       
  • Environmental parameters modulate lead chloride toxicity on Artemia salina

    • Authors: Suham Nowrooz Mohammad, Andreia Adelaide Gordinho Pinto, Mirian Oliveira Nagai, Ednar do Nascimento Coimbra , Ivana Barbosa Suffredini, Giovani Bravin Peres, Maria Martha Bernardi, Leoni Villano Bonamin
      Pages: 09 - 09
      Abstract: Introduction: Different environmental conditions can influence the effects of toxic agents on living beings. Recently, a series of experiments performed in Artemia salina submitted to different kinds of intoxication have shown that both, isotherapic and succussed water can change Artemia salina´s bio resilience at different levels. Moreover, it seems to vary according to the circalunar cycle. Objective: To verify if circalunar phases and water agitation can modify the toxicity of lead chloride on Artemia salina in vitro. Methodology: Artemia salina cysts were exposed to seawater containing 0.04% of lead chloride (equal to EC10 or 10% effective concentration, previously determined in a pilot study) in 96-well culture plates. Thirty-six experimental repetitions were performed in four series to observe the possible effects of adding stirred water, the so-called succussed water, and the moon phases. The hatched cysts were recorded after 48 hours using a digital microscope (1000x magnification) to identify the hatching percentage and the viability and mobility of the born nauplii. Results: The exposition of cysts to PbCl2 led to an increase in the hatching rate, and it was more evident during the full moon (p = 0.00014) The addition of succussed water into the seawater medium reduced this effect to the baseline levels. An increase in mobility was seen in nauplii born from exposed cysts during the full moon (p = 0.00077), but this effect was not affected by the treatment with succussed water. Discussion: Although the effects of lead chloride EC10 on the increase of nauplii hatching were expected, two environmental variables changed the sensitivity of cysts to this harmful stimulus. The circalunar cycle varied the hatching rate according to the moon phase, even in laboratory conditions, and the addition of succussed water into the medium reduced the hatching rate, even with different intensities according to the moon phase. The organization of nano and microbubbles generated after the succussion of water could be related to this protective effect and can explain, at least partially the effects of high diluted preparations on this biological context. Conclusion: Environmental factors, such as the circalunar cycle and products of water agitation, can modulate the adaptative control of hatching in Artemia salina exposed to lead chloride at EC10.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1171
      Issue No: Vol. 21, No. 1 (2022)
       
  • Evaluation of homeopathy effects associated with conventional periodontal
           therapy in randomized treatment of diabetic and non-diabetic patients with
           periodontitis

    • Authors: Leila Mourão, Miriam Alhanathi, Romeu Carillo Jr., Antonio Canabarro, Ricardo Fischer
      Pages: 10 - 10
      Abstract: Introduction: Periodontitis and Diabetes Mellitus type 2 (DMII) are chronic diseases treated by conventional practices and traditional medicine. In many cases, when conventional medicine cannot offer a satisfactory treatment, increases the demand for alternative therapies in chronic conditions. The aim of this study randomized was to compare and evaluate for one year clinical and serologic parameters the effects of homeopathy as an adjunct of conventional periodontal therapy in individual with periodontitis and DMII. Materials and Methods: 85 individuals, of both genders, between 35 and 70 years old, participated in this randomized study, which 70 were eligible in Institute of Endocrinology and Diabetes of Rio de Janeiro-Brazil. They were divided into two groups G-1: individuals with periodontitis without systemic conditions and G-2: individuals with periodontitis and DMII. Both groups received homeopathic treatment and were evaluated in clinical and laboratorial examinations. The medication used was chosen based on the similarity principle, following the Berberis 6CH protocol (2 tablets, 2 times a day for 45 days), Mercurius Solubilis / Belladona / Hepar Sulfur - 6CH (2 tablets, 3 times a day for 15 days) and a Pyrogenium 200CH biotherapeutic (single weekly dose, 2 weeks). Medications are prescribed in diluted low concentration doses for all signs and symptoms, while biotherapy is used for chronic stimulation Results: Both groups showed significant improvements throughout the study, clinical and laboratorial, at 1 year baseline: reductions in total cholesterol, triglycerides, glucose, glycated hemoglobin, uric acid and CPR. Statistical and descriptive analyzes were performed. The data obtained after laboratory analysis were tabulated and then submitted to the SPSS 17.0 software for Windows (SPSS Inc., Chicago, IL) and significance level with p <0.05. For most of parameters, G-1 performed better than G-2 (p<0.05).  Conclusion: After 1 year follow-up this clinical trial suggest that homeopathy therapy, as an adjunct of periondontal treatment, improves local and systemic parameters and can provide better health condition.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1172
      Issue No: Vol. 21, No. 1 (2022)
       
  • Evaluation of the effectiveness of arnica montana 6ch in the control of
           postoperative myalgia by isometric effort in dentistry

    • Authors: Rosy de Oliveira Nardy, Adriana Marques Nunes, Leonardo dos Santos Barroso, Cristina Garani Schneider Guimarães
      Pages: 11 - 11
      Abstract: Introduction: Arnica montana 6CH is a medicine indicated for inflammatory and painful conditions, especially in muscle structures. The RDC / TMD Axis II questionnaire is a validated tool for the diagnosis of Temporomandibular Muscle Dysfunction. Objective: This multicenter, randomized and controlled study, approved by Human or Animal Research Ethics Committee UniFOA - CAAE: 48680015.3.0000.5237 aimed to verify the clinical performance of Arnica montana 6CH in contractures and muscle pain triggered by isometric stress. Materials and Methods: 70 patients underwent prolonged dental treatment sessions, and they were selected after clinical examination and positive responses to the RDC / TMD questionnaire to confirm signs and symptoms of Temporomandibular Muscle Dysfunction at the first consultation. Randomly, Arnica montana 6CH was prescribed for 35 patients called group I, and placebo for 35 patients called group II, at a dose of 5 globules, 03 times a day, for 1 week. In the second endodontic consultation, after 15 days, a new clinical examination was performed at the beginning and end of the prolonged dental consultation with crossing of data from the RDC questionnaire, to monitor the prevalence of TMD muscle signs and symptoms. The data were tabulated and analyzed. Statistical analysis: The test t de Student was used for paired samples, significant at the level ≤ 0.05%. Results: Anamnetic data from the RDC questionnaire, 86% of the individuals in the GI had lower pain and muscle contracture rates in the second consultation, compared with 22% in the GII. Conclusion: The drug Arnica montana 6CH proved to be effective in preventing muscle changes and clinical symptoms resulting from isometric efforts with a statistically significant difference (p ≤ 0.05).
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1173
      Issue No: Vol. 21, No. 1 (2022)
       
  • Evaluation of the in vitro fungicidal activity of the dynamized essential
           oil of Aloysia polystachya before and after freezing

    • Authors: Talita Nader, Camila Yamasita Henrique, Alexandre Henrique Leonel, Ana Maria Soares Pereira
      Pages: 12 - 12
      Abstract: Background: The method of preserving substances of natural origin should not only maintain the microbiological safety of the product but also the integrity of its therapeutic potential. Essential oils obtained from plants are complex mixtures of substances and it is suggested to keep them under refrigeration for better conservation. On the other hand, homeopathic mother tincture prepared from plant is kept at room temperature. Aim: This work aimed to evaluate if the freezing process changes the in vitro antifungal activity potential of the homeopathic preparation Aloysia polystachya 1CH against Candida albicans. Methodology: The inoculum of C. albicans ATCC 10231 was cultivated in culture médium Sabouroud (Himedia®), standardized on a spectrometer and distributed in a 96-well plate. Then, A. polystachya 1CH was added to the wells, prepared according to the Brazilian Homeopathic Pharmacopoeia (FHB, 3rd edition) from A. polystachya essencial oil. An aliquot of this homeopathic preparation was frozen and after 40 days it was submitted to the same methodology for evaluation of the antifungal activity. After incubation, the plates were read with triphenyltetrazolic (TTC) (Vetec®). Results and discussion: The results of the in vitro evaluation showed that the freezing process retained the antifungal activity of the dynamized essential oil of A. polystachya 1CH against C. albicans. Conclusion: Under the conditions evaluated in this study, the freezing method presented as a viable method of conservation of dynamized plant material.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1174
      Issue No: Vol. 21, No. 1 (2022)
       
  • Exposure of Artemia salina to glyphosate and bioremediation by isotherapy

    • Authors: Mirian Oliveira Nagai, Andreia Adelaide Gordinho Pinto, Adalberto von Ancken, Ednar do Nascimento Coimbra , Sandra Augusta Gordinho Pinto, Suhan Nowrooz Mohammad, Ivana Barbosa Suffredini, Maria Martha Bernardi, Leoni Villano Bonamin
      Pages: 13 - 13
      Abstract: Introduction: Artemia salina, an ecotoxicity bioindicator, is a microcrustacean belonging to the order Anostraca. Glyphosate is an herbicide widely used to control weeds. However, its intoxication can cause serious damage to human health and the balance of the environment, given its effects as an endocrine disruptor. Objective: verify the possible protection of the artemia exposed to glyphosate by the addition of its isotherapic into water, by means of the evaluation of the behavioral and morphological features of nauplii and of the physical properties of remedies and treated water, to elucidate the involved mechanisms. Methods: Artemia salina cysts were kept in culture bottles containing artificial seawater containing glyphosate at LC 10 (lethal concentration 10%), to promote hatching within 48 hours. The isotherapic preparations were inserted in each bottle in a 10% of the total water volume. Part of the nauplii was distributed in transparent tubes, being 10 nauplii per tube and 6 tubes per group, for behavioral analysis, and part were collected for a detailed morphological analysis, under an optical microscope. About 80 to 270 nauplii were analyzed per group. The reserved water was divided into aliquots for physicochemical analysis, that is, evaluation of the water dipole behavior by Cartwright´s method. Results: Gly 6cH presented selective effects on nauplii hatching (p=0.02) and on defected/healthy ratio (p=0.001), representing some protective action. This result was dependent of the salinity of water and presented correspondence with the effects on solvatochromic dyes, indicating that charges and ions can be critical factors involved in the mechanism of action. We concluded that the use of isotherapics could be a plausible tool to reduce the environmental impact of the indiscriminate use of glyphosate, since these results can be reproduced in further studies.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1175
      Issue No: Vol. 21, No. 1 (2022)
       
  • Heteroisotherapics effect on the treatment against smoking: a
           cognitive-behavioral approach

    • Authors: Adriana Passos Oliveira, Mary Lannes Salles Leite, Fortune Honsani, Juliana Patrão Paiva, Rafael Tritany, Carla Holandino
      Pages: 14 - 15
      Abstract: Background The most common way of consuming nicotine is in tobacco cigarettes. Nicotine causes intense addiction. The National Cancer Institute coordinates and executes the Tobacco Control Program in Brazil, through actions that encourage the adoption of healthier lifestyles. In this context, homeopathy has used Heteroisotherapic medicines formulated according to the homeopathic pharmaceutical technology with scientific evidence of efficacy in the detoxification of substances and metals, and in the desensitization of foods or medicines. Aims Promote the importance of the cognitive-behavioral approach in combination with the homeopathic treatment against smoking. Methodology In the initial phase of the randomized double-blind clinical study (CEP / HUCFF / UFRJ 65622916.2.0000.5257), the effectiveness of the 6CH heteroisotherapeutic drug was assessed. Volunteers were recruited and in-person welcoming meetings, using the cognitive-behavioral approach, were carried out to inform them about the risks of smoking and the benefits of quitting. In addition, they were supported and guided during the smoking cessation process so that they could deal with the withdrawal syndrome, the psychological dependence and the constraints associated with smoking. Results and discussion 84 participants were selected according to the inclusion criteria, and divided by randomization into two groups: the Test Group (heteroisotherapeutic medication) and the Control Group (homeopathic medication Nux vomica 6CH). Both groups will be followed for 12 months. The combination of the following approaches has led to a significant increase in the cessation rate: I. Prepare the smoker for solving his own issues; II. Stimulate skills to resist temptations to smoke; III. Prepare to prevent relapse; IV. Prepare to deal with stress. Studies show that, regardless the duration of these approaches, there is an increase in the abstinence rate. Moreover, the longer the total approach time (frequency multiplied by the time spent on each contact), the higher the abstinence rate. On the other hand, from a total approach time of 90 minutes on, there is no further increase in the abstinence rate. Conclusion The partial results obtained so far demonstrate that the cognitive-behavioral approach played a decisive role in the groups performance, favoring the treatment adherence as well as the group cohesion around the Project's objective, contributing to the effectiveness of the medicine, a decreased anxiety, improved sleep, cessation or decrease in the number of cigarettes smoked per day and the abstinence rate.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1176
      Issue No: Vol. 21, No. 1 (2022)
       
  • High Dilution in Dyslipidemia treatment in Dogs and Rabbits

    • Authors: Cidéli de Paula Coelho, Bruna Scardoeli
      Pages: 16 - 16
      Abstract: Background: Excess weight causes disorders in locomotor, cardiorespiratory and reproductive systems and increases the incidence of endocrinopathies, as well it can often cause dyslipidemias, leading to atherosclerosis. Aims: Report the evolution of homeopathic treatment in 4 overweight patients, being 2 female dogs and 2 female rabbits with hypertriglyceridemia, analyzing the values in biochemical test. Methodology: Homeopathic treatment was chosen, based on the principle of similitude, using Cholesterinum due to its action to decrease cholesterol and triglyceride levels. Results: The same protocol was made for all of the four patients, included 2 globules of Cholesterinum 30CH direct in its mouth, every 12 hours for 30 days. The first dog attended on 01/09/2019, presented 328 mg/dL of triglycerides, decreasing this level to 132 mg/dL after just one month treating. The second dog attended on 04/05/2019, presented higher hypertriglyceridemia with 617 mg/dL that decreased to 259 mg/dL. Likewise, on 02/06/2019, the first rabbit attended, presented 445mg/dL of triglycerides, which reduced to 337 mg/dL, while the second rabbit, on 06/27/2019, presented 372 mg/dL of triglycerides, decreasing to 274 mg/dL after. Although the values of cholesterol in all patients were in agreement with the reference, the treatment still proved improvements. In the beginning of the treatment, the first dog showed 207 mg/dL of cholesterol and in the end, it reduced to 170 mg/dL, as well with the second dog with 218 mg/dL in the beginning and 200 mg/dL after. Regarding rabbits, the first one presented inicial value of 60 mg/dL, which decreased to 52 mg/dL, while the second started with 57 mg/dL and went to 41 mg/dL. Conventionally, Bezafibrate is indicated as a lipid-lowering agent, but it is contraindicated in patients with liver or kidney failure, vesicular diseases and for pregnant or lactating. Conclusion: Dyslipidemia can be controlled with High dilution. (The exposed information is consented by the tutors)
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1177
      Issue No: Vol. 21, No. 1 (2022)
       
  • Homeopathic medicine activity on the growth of Gram-negative bacteria

    • Authors: Audrey de Souza Marquez, Tania Aguiar Passeti, Susana Nogueira Diniz, Everton Tadeu Prado
      Pages: 17 - 17
      Abstract: Introduction: Homeopathy is a therapy that uses medications prepared with infinitesimal and dynamized dilutions. Current studies demonstrate in vitro activity of homeopathy on gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. Among bacterial infections, urinary tract infection (UTI) is frequent, leads to later consequences and the main causal agent is Escherichia coli (E. coli). In other publications, it has been reported inactivity of homeopathy on E. coli cultures. Due to the divergence in the literature, the objective of this study was to evaluate gram-negative bacteria growth under homeopathy treatment. Methods: The medicines Atropa belladona, Cantharis, Staphysagria, and Colibacillinum were tested at 6CH, 12CH and 30CH in E. coli ATCC 25922 and EPEC (Enteropathogenic Escherichia coli) ATCC 43887. Two hundred and fifty microliters of the medicines in alcohol 30% were incubated at 37ºC with 3 mL of Müller Hinton broth (MH), 10 μL of cultures at 0.5 Macfarland and subsequent dilution at 1/10. Bacterial growth was evaluated in a spectrophotometer at 600nm, in the periods of 6, 12, and 20 hours of incubation. Results and Discussion: The results showed no inhibition of bacterial growth under the studied conditions. These data corroborate with studies already published that indicate the absence of action of homeopathy on E. coli cultures. Considering other studies, it can be suggested that homeopathic medicines have direct activity on the growth of Gram-positive and not Gram-negative bacteria. Evaluating the two bacterial groups, it is possible to assume that the difference in homeopathy activity could be linked to differences in the bacterial wall structure. This hypothesis should be evaluated by other tests with the same bacterial strains. Conclusion: The homeopathic medicines tested have no direct activity on Gram-negative bacteria cultures.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1178
      Issue No: Vol. 21, No. 1 (2022)
       
  • Homeopathy on cultures of Saccharomyces cerevisiae and impact on
           fermentation

    • Authors: Tania Aguiar Passeti, Vinícius Crescêncio Queiroz, Roberto Lopes Almeida, Susana Nogueira Diniz, Audrey de Souza Marquez
      Pages: 18 - 18
      Abstract: Introduction: Studies have shown that homeopathy modulates the activity of both single-and multi-celled organisms; therefore, we propose a study into the action of Arnica Montana and S. cerevisiae fungus nosode on growth “in vitro”, and on the fermentation of S. cerevisiae on brewer’s wort. Methods: 250 µL of medication in 30% alcohol were placed in 5 mL of Sabouraud Broth (SB) or wort, with 20 µL of fungus ata McFarland standard of 0.5 and in a dilution of 1:100. Fungal growth was evaluated via spectrophotometry at 600 nm or a cell count in a Neubauer chamber in a kinetic of 1 to 5 days’ incubation at 25ºC. The production of alcohol by the fungus was evaluated using the BRIX index in the same kinetic. 1x107 fungi/mL were previously incubated with medication for 5 days and, afterwards, placed in 20 mL of fresh wort, incubated at 25ºC for 7 days and evaluated for growth and sugar consumption. Results and Discussion: The SB results revealed that after 2 days incubation with Arnica 30CH, an increase in fungal growth was observed (p<0.0001), while with nosode 6 and 30CH there was a reduction in growth after 2 and 5 days incubation (p<0.001). The fungi incubated with Arnica 30CH exhibited increased sugar consumption after 2 and 5 days incubation (p<0.05), while the nosode 30CH resulted in lower sugar consumption after 2 and 3 days incubation (p<0.05). The results for fungal growth and sugar consumption with the wort were similar to those using SB. The fungal cultures previously incubated with homeopathic medication and subsequent incubation with fresh wort indicated a loss of distinction, both in terms of fungal growth and sugar consumption. This piece of data may suggest action by the homeopathic medication only when in contact with the cells. Conclusion: The treatment of the S. cerevisiae fungus using Arnica and the S. cerevisiae nosode produced a significant modulation in fungal growth and sugar consumption.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1179
      Issue No: Vol. 21, No. 1 (2022)
       
  • In vitro evaluation of Sporothrix brasiliensis biotherapic

    • Authors: Gleyce Moreno Barbosa, Amanda Ribeiro Ricardo Brito, Lais Cavalcanti dos Santos Velasco Souza, Andrea Regina de Souza Baptista
      Pages: 19 - 19
      Abstract: Background: Sporothrix brasiliensis is one of the most virulent zoonosis which affects animals and humans. This fungus is responsible for subcutaneous infection and its contamination is possible through trauma to the skin. Sporotrichosis is highly prevalent in feline. And Rio de Janeiro appears to have the highest occurrence of cases. Objectives: This study aims to evaluate the in vitro efficacy of Sporothrix brasiliensis biotherapic, with and without an association to allopathic medicine commonly used in the treatment. Methodology: Conidium cells of Sporothrix brasiliensis will be cultured in Potato dextrose agar (PDA) for 5 to 7 days and yeast cells in Brain heart infusion (BHI) for 3 to 5 days. After incubation, the cells will be scraped with a drigalski handle and filtered using cells strainer into a tube and centrifuge for 5 minutes at 3000 RPM. The cells will be resuspended with Phosphate buffered saline (PBS), centrifuge again, and finally resuspended in PBS. After preparing the inocule, the microplates will be prepared. There will be 5 groups in vitro. The first one will be the control group, only fungi. The second will be the treatment of fungi with homeopathic medicine (Sporothrix brasiliensis 30DH). The third group will be the homeopathic medicine in association with itraconazole. The fourth will be the treatment with itraconazole only. And the last group will be the fungi with dynamized distilled water 30DH. Sporothrix brasiliensis 30DH will be prepared according to Brazilian Homeopathic Pharmacopeia. Results and discussions: The experiments are still in progress and the results will be analyzed through Analysis of variance (ANOVA) to determine statistically significant differences. Previous articles based on biotherapic treatments demonstrated successful results, so our research group is conducting these experiments to evaluate the effect in this model. Conclusion: Experiments will be made to verify the efficacy of biotherapic on sporotrichosis treatments. 
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1228
      Issue No: Vol. 21, No. 1 (2022)
       
  • In vitro evaluation of the effects of Viscum album homeopathic
           preparations on murine melanoma cells

    • Authors: Priscila Baltuille Prado, Carla Holandino, Stephan Baumgartner, Thaís Cristina Silva, Leoni Villano Bonamin, Elizabeth Cristina Pérez Hurtado
      Pages: 20 - 20
      Abstract: Background: Viscum album extract (VA) is a complementary treatment in cancer, with in vitro and in vivo cytotoxic effects on several tumor types when applied in phytochemical doses. However, highly diluted ethanolic homeopathic preparations' effects and mechanisms need further study. Aims: To assess the in vitro effects of highly diluted VA from the subspecies V. album abietis and V. album album at different potency levels in different dilution ratios on murine melanoma cells. Methodology: The VA mother tinctures (MT) from Abies alba (MTA) and Quercus robur (MTQ) were prepared with summer and winter samples, harvested in Switzerland. They were submitted to homeopathic ethanolic maceration and a subsequent dynamization process. MTA, MTQ and the following respective potencies were tested in B16F10 murine cells: 3x, 12x, 30x, 6cH, 12cH, 200cH, 2LM, 3LM, and 5LM. Dynamized water, dynamized and non-dynamized ethanol, and carboplatin were used as control groups. The mitochondrial activity and cell viability analysis were performed at 1, 24, 48, and 72 hours by in vitro incubation. MTA and MTQ harvested in summer, as well as 12x, 200cH and 5LM potencies were also tested to cell apoptosis and necrosis markers, reactive oxygens species (ROS) production, inflammatory cytokines profile, cell morphology, and migratory capacity. Results and discussion: MTA and MTQ induced a decrease in cell metabolism and higher cytotoxicity within 1 hour, with significant morphological changes and increased production of ROS and inflammatory cytokines. Both homeopathic dilutions 12x and 5LM showed an influence on cell metabolism, cell replication, and oxidative stress modulation with inflammatory cytokines, mitosis, and migration pattern changes. On the other hand, Quercus robur and Abies alba 200cH showed increased on cytotoxicity and ROS levels, respectively. Conclusion: The in vitro effects of Viscum album homeopathic solutions in melanoma cells highlight the promising antitumoral potential and reinforce the need for further research to better understanding their mechanisms of action.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1182
      Issue No: Vol. 21, No. 1 (2022)
       
  • Influence of homeopathy on the quality of quail eggs stored for different
           periods of time

    • Authors: Mônica Filomena Assis Souza, Wellington Santos, Jean Kaique Valentim, Rodrigo Garófallo Garcia, Maria Fernanda de Castro Burbarelli, Felipe Cardoso Serpa, Gisele Aparecida Félix, Gabriella Galvão Pizarini Nascimento, Bruna de Souza Eberhart, Pedro Henrique de Souza Cucco, Marco Antonio Cucco, Karine Bonucielli Brum
      Pages: 21 - 21
      Abstract: Introduction: The purpose of this trial was to assess the influence of homeopathy products on the diet of quails based on egg quality when submitted to different storage periods. Methodology: Two hundred, 45 day old Japanese quails and 80% of production were used, in a completely randomized design comprised of a 4x3 factorial, and 4 diets (basal feed, inert vehicle and 2 homeopathic products: Fertsigo® (Sulphur 10 CH, Sepia 15CH )  and Ovosigo® (Belladonna 12CH,Silicea 12 CH, Natrum mur. 30CH, Calcarea phos. 30CH, Sulphur 12CH) and 3 storage periods (0 days, 7 days and 14 days) with ten repetitions of three eggs per treatment. The weight, percentages of yoke, albumen and shell, albumen height and yolk color, specific gravity, Haugh unit, yolk index and shell thickness were evaluated. The data were submitted to variance analysis to verify whether there was a interaction effect between homeopathy factors and storage time, and when absent, the isolated effects. Results: An interaction between the homeopathic products and time was found for the parameters of albumen height and yolk, Haugh unit and yolk index, which reduced over time. For egg weight, yolk, albumen and shell, a significant effect (p<0.05) was found only in the case of homeopathy for the percentages of albumen and shell. For egg and albumen weights, yolk and albumen percentages, specific gravity and colorimetry there was an effect for time, however these parameters reduced over the storage time in days. The addition of the homeopathic based products Ovosigo® and FertSigo® are indicated for the diets of Japanese quail during the laying phase since it resulted in better weights for the egg and its components. Conclusion: The different homeopathic products did not have an influence on conserving the quality of the Japanese quail eggs during the periods evaluated.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1183
      Issue No: Vol. 21, No. 1 (2022)
       
  • Lycopodium as a treatment for Urate Deposition (gout) in birds: case
           report

    • Authors: Cidéli de Paula Coelho, Sônia Regina Pinheiro, Adalberto von Ancken
      Pages: 22 - 22
      Abstract: Background: A 3-year-old male cockatiel (Nymphicus hollandicus) was diagnosed with joint arthritis due to hyperucemia syndrome. The bird presented deposition of urate crystals on the synovial membrane with inflammation of joints and tendons (tufts), causing listlessness, anorexia and lameness, with difficulty in keeping perched or moving. Laboratory tests displayed an increase in uric acid and creatinine phosphokinase levels, and leukocytosis despite lymphopenia. Unsucessfully, the animal had been treated with allopathic medicine for 2 months, without a favorable response and still developing stressful reaction to handling. Methodology: High dilution therapy was attempted with 2 globules of Lycopodium clavatum 30 cH /bid and Arnica montana 30 cH /bid /oral. The most expressive tufts were removed with daily cleaning of the affected area; a new diet was established and perches were removed, allowing the bird to remain on a flat surface until regression of symptoms. The medication was continued for 30 days. On the second appointment, although the caregiver reported episodes of probable pain, there was an improvement in behavior with normal appetite. Lyc 30cH /sid was continued and Arn 30cH /bid to qid, depending on pain episodes, for over 30 days. The tutor authorized the case report through a consent form. Results and discussion: Follow-up laboratory tests were performed every three months for one year, reaching normal levels ​​for uric acid (3.5-11 mg/dL) and CK (30-245mg/dL) on the third measurement. The bird presented no formation of new tufts along the second month of treatment. After 12 months, the animal ingests homeopathic globules spontaneously and presents stable clinical presentation (Lyc 30cH / sid / 3 times a week) with no recurrence and without side effects nor stressful behavior. Conclusion: In view of these results, it is considered that homeopathic treatment is an option to be considered in the treatment of joint arthritis from hyperuricemia syndrome in birds.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1185
      Issue No: Vol. 21, No. 1 (2022)
       
  • Lycopodium clavatum as a homeopathic treatment in Magellanic penguins
           (Sphenicus magellanicus)

    • Authors: Cidéli de Paula Coelho, Hugo Gallo, Francinne Brait Narita
      Pages: 23 - 23
      Abstract: Background: Uric acid is the main form of excretion of nitrogenous components in birds. The assessment verification samples, control, check of uric acid concentrations is widely used to detect kidney disease. High concentrations (up to five times) of uric acid in plasma can lead to the precipitation of this acid in the form of crystals, which accumulate in the tissues, mainly in the synovial joints and the viscera surface. Aims: report the evolution of homeopathic treatment in increased uric acid in Magellanic penguins (Spheniscus magellanicus) from Santo André Municipal Zoo. Methodology: 12 animals showed an increase in uric acid (reference values 0,3-16,1mg/dL) and received homeopathic treatment with Lycopodium clavatum 6cH. The protocol established was the administration of two globules of Lycopodium clavatum 6cH, once a day, inside fishes offered in the animal's beak. Treatment started on 25/09/2019. On 30/10/2019 was collected a new blood sample, those who were not discharged were kept on treatment and new collections were made on 27/11/2019 and 17/12/2019. Results: 8 animals had an average uric acid of 20.45mg /dl and responded to the 35-days treatment, normalizing the biochemical values ​​with an average of 12.24mg /dl. Two animals with 18.27 mg /dl were discharged in 62 days with 11.70 mg /dl and another two penguins with 19.85 mg /dl were discharged in 82 days later with 9.57 mg /dl of uric acid. Conclusion: Homeopathy proved to be successful in the treatment of increased uric acid in Magellanic penguins, easy to administer, affordable and without side effects.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1186
      Issue No: Vol. 21, No. 1 (2022)
       
  • Macrophage activity regulation by high dilution of aspirin and its
           possible mechanism

    • Authors: Adalberto von Ancken, Francisco Xavier Eizayaga, Leoni Villano Bonamin
      Pages: 24 - 24
      Abstract: Background: Under LPS-stimulus, platelets can activate macrophages by a cell-to-cell contact or through cytokine degranulation. Rebound effects of anti-thrombotic agents, such as prostanoids and COX inhibitors can lead to thrombosis, infarct, and stroke. Aspirin has been prescribed for decades due to its powerful antiplatelet action, but it is also related to paradoxical effects such as withdrawal syndrome peaks, resistance, and thrombogenesis. Ultra-diluted aspirin can also produce the same effect in one hour, regardless of Cox-2, by still unknown pathways. Antithrombotic effects of aspirin are also reversed by its high dilutions. Aims: This study aims to characterize the effects of aspirin 15cH on macrophages challenged with LPS, a Cox-2 activator. Methodology: RAW 264.7 macrophages were sown in 24 wells plates using R10 medium, boosted with 1μg/ml LPS, and treated with aspirin 15 cH and controls. The activity was evaluated after 24 hours. Supernatants were evaluated for cytokines, nitric oxide, and dielectric oscillations, through solvatochromic dyes (Cartwright’s method). Results and discussion: macrophage spreading was increased by aspirin 15 cH, an LPS-like effect. Paradoxically, a significant reduction of this effect was noted when both, LPS and aspirin 15 cH, were added. Succussed water reversed the effect of LPS, leading to TNF (p<0.05) production close to baseline levels. Also, the single treatment with succussed water inhibited IL-10 production (p<0.05), but aspirin 200 µg/mL (positive control) highly increased it (p<0.0001), showing the validity of the model. Nitric oxide production was strengthened by LPS presence (p<0.0001), as expected, but partially downregulated after treatment with aspirin 200 µg/mL, water and succussed water. A pilot study with solvatochromic dyes showed no significant difference among treatments. Conclusion: The main data suggest that aspirin 15 cH increases macrophage activity but presents a paradoxal effect when mixed with LPS. On the other hand, succussed water itself has modulatory effects on macrophages.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1187
      Issue No: Vol. 21, No. 1 (2022)
       
  • Neurobehavioral assessment of Danio rerio intoxicated by Mercury and the
           use of Mercurius solubilis

    • Authors: Cidéli de Paula Coelho, Marco Aurélio Gonçalves Manzoli, Rafael Acordi Santos, Elaine Bido, Henrique Carvalho Vieira
      Pages: 25 - 25
      Abstract: Background: Mercury is used in various industrial. Part of Mercury's industrial waste is discharged into the environment, rivers and their tributaries, thus contaminating aquatic animals. Aim: to evaluate Mercury-induced behavioral changes in Zebrafish (Danio rerio) by the analysis of locomotor activity and parameters related to neurotoxicity and to verify whether ultra-diluted substances can decrease neurobehavioral effects and toxic. Methodology: The fishes were separated into 4 monitoring aquariums with 8 fishes each, with temperature, pH controlled, until the time of the toxicological experiments. 0.5 mL of Mercury 6cH, 30cH and distilled water (positive control) were added per liter of water in each aquarium containing 6 liters of water, then 3 mL of medication per aquarium, the white control received no medication and the toxic agent. After 1 hour the drugs were added, toxic mercury (200 μg/L), 4 mL per aquarium was added and remained so for 24 hours. All the experiment was run in blind, and the drugs identified by codes. The animals were subjected to behavioral tests (Open Field-locomotion; Vertical Open Field for neurotoxicity evaluation and Light and Dark Test), and each stage was recorded for later evaluation of movements and neurobehavioral changes. ANOVA was performed, followed by Tukey test, with p <0.05. Results: Mercury produced an anxiogenic effect in animals that were submitted to it without medication. In the vertical open field, there was an increase in erratic movements (1.25 ± 1.0) and tremors (0.87 ± 0.35) compared to the control (0.12 ± 0.35 and 0.25 ± 0.46 respectively), proving the toxic effect. Fishes which received the medication at 6 cH and 30 ch showed tremors and erratic movements similar to control. Conclusion: 200 μg/L mercury in water can cause neurobehavioral disturbances in fishes, and animals receiving Mercurius 6 cH and 30 cH ultra-diluted drug did not show neurotoxicity.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1188
      Issue No: Vol. 21, No. 1 (2022)
       
  • Practical teaching of pathophysiology to LAFFH at the IPD outpatient
           clinic of FMP/FASE: Historical Report

    • Authors: Cláudio Hansel Martins, Victor Tito Sperduto, Roberta Malher Bernardo, Thaís Ferreira do Espírito Santo Pires, Marcia Cristina Braga Nunes Varricchio
      Pages: 26 - 26
      Abstract: Background: Undergraduate students of UNIFASE/FMP, through the Academic League of Human Physiology and Pathophysiology (Liga Acadêmica de Fisiologia e Fisiopatologia Humana - LAFFH), participate in a supervised internship to outpatient at the Infectious and Parasitic Diseases Service of FMP/FASE, authorized by Clinical Direction (October 2018). Patients received conventional therapy in addition to complementary therapy with Homeopathy, for external use for cleaning skin lesions and modulating inflammatory responses, whose mechanisms of action are already described in the scientific literature and authorized by ANVISA. Aims: Make approach of undergraduate students to Homeopathic pathophysiology. Methodology: The supervised clinical internship of LAFFH students is in two service rooms with 6 students in each, based on prior appointment due to spontaneous demand, with medical records registered by the IPD outpatient service secretary. Outpatient clinical care addresses the pathophysiology and miasms of the symptoms and signs of neglected chronic parasitic diseases prevalent in our country, identified by anamnesis and physical examination. They are correlated to biological activities in plant chemistry classes, besides official homeopathic pharmacopoeia.  So, it was adopted the external use of HUD Ledum palustre 6ch for the cleansing of skin lesions with torpid evolution at IPD. Results and discussion: Two patients with edema and varicose ulcers were treated with the ointment offered. Edema extension which was +++/4+ to both patients diminished to +/4+ in 30 days of interval. Indeed, ulcers remained at the same shape and size, but their bases were cleaned, without purulence. Novel clinical sessions did not occur because of social distancing needed. Conclusion: It has been developed a positive perception among patients and students about the action of homeopathic remedies. The practical teaching activity initiated encourages students in clinical reasoning about complementary therapeutic association with Homeopathy for patients whose evolution is below the expected prognosis with conventional therapy. Project of clinical observation will be elaborated to research ethics committee.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1189
      Issue No: Vol. 21, No. 1 (2022)
       
  • Reflections on the fundamental nature of homeopathic potencies: Plasma,
           Langmuir Adsorption and Vitalism

    • Authors: Steven John Cartwright
      Pages: 27 - 27
      Abstract: Background: There is a pressing need to develop methods and approaches that will identify the fundamental nature of homeopathic potencies. Aims: To bring together recent basic research on potencies, especially that using solvatochromic dyes, and to supplement these results with reliable observations made by Hahnemann and his contemporaries from the very beginnings of homeopathy, together with a detailed examination of the process of trituration and succussion coupled to dilution, in order to significantly limit the number of possible explanations as to the identity of potencies. Methodology: A mixture of lab based and literature studies such that as far as possible all verified and substantiated observations about homeopathic potencies have been examined. Results and Discussion: An understanding of the fundamental nature of homeopathic potencies that includes all known and accepted observations (in vitro, in vivo and clinical) is not realistic without embracing hypotheses involving the emergent properties of complex systems and in particular, vitalistic concepts. Using a vitalistic model it is possible to explain a wide range of seemingly unrelated phenomena - such as the polarising effect of potencies on solvatochromic dyes, the ability to use a range of materials such as water, lactose and cellulose as carriers of potencies, the administering of potencies by olfaction, the antidoting effect of camphor on potency action, the non-linear dependence of potency strength on volume as well as succussion level, the oscillatory behaviour of potencies and experimenter/observer/practitioner effects. Conclusion: A hypothesis in which homeopathic potencies can be seen as self-actuating and autonomous plasma generated by trituration and/or succussion and carried according to Langmuir adsorption models fits the known observations about potencies.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1190
      Issue No: Vol. 21, No. 1 (2022)
       
  • Series of experiments performed with the droplet evaporation method on low
           potencies

    • Authors: Maria Olga Kokornaczyk, Sandra Würtenberger, Stephan Baumgartner
      Pages: 28 - 28
      Abstract: Introduction: Homeopathic preparations in low potencies, containing still measurable quantities of the starting substance, constitute a unique research field in homeopathic basic research. Here a series of experiments is presented carried out by means of the droplet evaporation method (DEM), investigating the specificity of the method, and presumed effects of the succussion procedure applied in the production of homeopathic preparations. Methods: DEM analysis consisted in the evaporation of droplets of the potencies per se placed on microscope slides. Resulting patterns were photographed. Images were evaluated by means of ImageJ software, by measuring grey level distribution, texture, and fractality. The experimentation consisted of four series: (i) screening (1x–6x potencies from 19 substances), (ii) differentiation experiments (2x–6x potencies of Echinacea, Baptisia, Luffa, and Spongia), (iii) differentiation between succussed (100 or 10 times) and unsuccussed samples (Echinacea 2x, Baptisia 3x, Baptisia 4x, Luffa 4x, and Spongia 6x). (iv) investigation of the influence upon the patterns of single compounds present in a remedy complex. The experimental set-up stability was examined by systematic positive control experiments. Results: (i) Homeopathic preparations of mineral origin showed the greatest form variety, whereas those of vegetal origin created fractal patterns in the potency range 2x–4x. (ii) Differentiation of potencies of different origin at the same dilution level was possible from 2x to 4x. (iii) In all potency levels, succussed (100 and 10 times) and unsuccussed variants could be significantly differentiated. Significant differences between all variants were found in some cases in potency levels 4x and higher. In general, application of succussion reduced size, homogeneity, and complexity of the DEM patterns. (iv) Patterns of a remedy complex Luffa 4x - Mercurius bijodatum 9x showed a clear predominance of the Luffa 4x; however also the second component, present in a much lower concentration, influenced significantly the pattern of the remedy complex as also differed significantly from the pattern of succussed water control. Conclusions: The results suggest that DEM is a suitable tool for scientific investigation of homeopathic preparations in the low potency range. DEM might be applied to assess further research questions, such different potentization procedures (vessel shape, overhead volume, material), storing time, and difference between batches.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1191
      Issue No: Vol. 21, No. 1 (2022)
       
  • Stress - another possible mechanism of neurotoxicity in neurodegenerative
           diseases

    • Authors: Maria Filomena Xavier Mendes, Paulo Oliveira, Maria Solange Gosik , Renata Garcia Lino, Raquel Bruno Kalile, Danielle da Silva Barbas, Romeu Carillo Jr
      Pages: 29 - 30
      Abstract: Background: The literature associates oxidative stress with the production of free radicals, which lead to neurodegeneration. They present innumerable hypotheses, among which are abnormalities in the functioning of the hypothalamic-pituitary-adrenal axis, neurotoxic effects and neuronal oxidative damage. Clinical observation has shown that in neurodegenerative diseases such as Multiple Sclerosis (MS) and Amyotrophic Lateral Sclerosis (ALS) there is a report of prolonged or violent emotional stress preceding the symptoms. Aims: Using the Carillo Complex Systems Model, present some possibilities on how stress can contribute to neurodegeneration. Methodology: Nine cases of ALS and six cases of MS were evaluated, pathologies already classified as belonging to syphilinism. Literature review on stress and neurotoxicity carried out. Results and discussion: Syphilinism is an instability with a predominantly intrisic origin to the system with a chronic caracter. This diathesis characterized by a dissipative deficiency, predominantly hepatic, to the processing of certain elements or potentially toxic substances with exogenous origin or endogenous Such non-processed substances are unstable factors in the system, with greater affinity for certain tissues, like the nervous system. Among the toxins, we find alcohol, esters, formaldehyde, aloe, ketones, aldehydes, etc. The final hepatic metabolism of cortisol results in cortic acids and cortol, which use the same enzymatic system as alcohol, and can be considered syphilinic toxins. Ethanol can act directly at the circadian rhythm, disrupting it and generating stressful substances such as cortisol, regardless of an external event, increasing the toxin level. The inflammatory process generated by the production of free radicals and metabolic abnormalities, including the reduction of neuropeptide Y that modulates inflammatory activity in the nervous system, leads to changes that can result in neurodegeneration. Conclusion: Inflammation caused by toxins from
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1192
      Issue No: Vol. 21, No. 1 (2022)
       
  • Teaching and practice in Homeopathy via pharmacobotany and pathophysiology

    • Authors: Cláudio Hansel Martins, Patrícia Musmanno, Sandra Ávila Gaspar, Josiane Bentes, Rosana Ximenes, Denise Nagamatsu, Fábio Tavares, Fábio Bolognani, Marcia Cristina Braga Nunes Varricchio
      Pages: 31 - 31
      Abstract: Background: Semiology, Clinical Pathophysiology, Phytotherapy and Homeopathy were taught through active methodology by the Moodle platform (HL) also using apps for monitoring injuries through SAPB site, building rationality for the external topic use of homeopathic and herbal medicines. At the 7th Infirmary of General Hospital Santa Casa de Misericordia in Rio de Janeiro, the clinical medical team of the Benoit Mure Nucleus of Assistance Teaching and Research, made a medicinal plant garden with the agricultural/environmental educator, and community ethnical leaders. Undergraduate students from UNIFASE/FMP Academic League of Physiology and Pathophysiology planted Calendula Officinalis seedlings, destined to research in pharmacobotany and to be in touch with pharmacotechnical prepares. Aims: To follow-up the study since from seedling of Calendula Officinalis till to prepare of HUD. Methodology: To prepare medicinal garden: plant seedlings of Calendula offin accordance with good agricultural techniques. At first: Three seeds in ten pots, made in triplicate (N = 90), to obtain explants of quality analyzed whose evaluation was about plant development (explants percentual: weight, size, viability, morphology). To visit pharmacy-school to learn how to prepare matrix extracts and High Ultra-Diluted Solutions (HUD) of Calendula off 6DH. Results and Discussion: The stages of teaching semiology and practice in pharmacobotany, besides cultive plant have been completed. Viability was impaired because of lack of irrigation during 4 months (50%). Weight, size were minor than usual but with no statistical significance (p>0.05). Morphology was maintained. Unfortunately, the visit to pharmacy-school couldn’t be performed at this period. Conclusion: Through hybrid learning and face-to-face activities completely realized, students had qualitative perception of the relevance about morphology and quality of plant development, chemistry plant production, aiming for resolutive actions based upon pathophysiology of chronic diseases. Because of pandemic, it was described just a preliminary experience. After returning to normal activities the experiment will be repeated.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1193
      Issue No: Vol. 21, No. 1 (2022)
       
  • The use of homeopathy and flower therapy as an aid in the treatment of
           climacteric symptoms: an integrative review

    • Authors: Camila Faria de Amorim Pereira, Adriana Passos Oliveira
      Pages: 32 - 32
      Abstract: Climacteric is characterized as the set of symptoms that usually start in the period of transition from the reproductive phase to female senility, and directly impacts woman's quality of life. Currently, the treatments approved by the FDA for this pathology mainly involve the use of antidepressants and hormone replacement, both having side effects. Clinical studies carried out in 2002, showed an increased risk of breast cancer, and other pathologies related to the prolonged use of these drugs. The impact of the studies resulted in a greater interest in complementary and alternative medicines (CAMs), such as the use of homeopathy and flower remedies for the treatment of climacteric symptoms. This abstract aims to present an integrative review on the use of homeopathy and flower remedies in the treatment of climacteric symptoms, in order to identify it main scientific evidence. For this, metodology consisted of research in the databases Web of Science, Google Scholar, HomeoIndex, LILACS and SciELO. The inclusion criteria were original human studies, totally available, and published in the last 10 years in Portuguese, English and Spanish, presenting the use of floral remedies or homeopathic treatment. The main homeopathic medicines used were Lachesis mutus, Belladona, Sepia officinalis, Sanguinaria canadensis and Sulfur. The main flower remedies were Cherry plum, Agrimony, Gentian, Walnut, Olive and Larch. The findings in this review demonstrate a positive outcome trend in favor of the effectiveness of these practices through the studies evaluated, encouraging the expansion of new designs and research that fully contemplate the principles of these practices. Thus, this work contributes to the advancement in the understanding of each one of these rationalities, making this work a source of consultation for health professionals and for future research, resulting in a strengthening of CAMs in the field of health.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1194
      Issue No: Vol. 21, No. 1 (2022)
       
  • Viscum album L. homeopathic mother tinctures: Metabolome and antitumor
           activity

    • Authors: Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Rafael Garrett, Patrícia Zancan, Alan Clavelland Ochioni, Mirio Grazi, Hartmut Ramm, Tim Jaeger, Stephan Baumgartner, Carla Holandino
      Pages: 33 - 33
      Abstract: Background: Viscum album L. is a semi-parasitic plant with antitumor activity attributed to the aqueous extracts. However, European V. album ethanolic extracts (VAE) have also demonstrated in vitro activity in tumor models. Aims: Evaluate the metabolic profiles of fifty VAE harvested during summer and winter seasons and their antitumor activity through 2D and 3D models. Methodology: VAE were prepared by maceration from: V. album subsp. album growing on Malus domestica, Quercus sp.     and Ulmus sp.; V. album subsp. austriacum from Pinus sylvestris; V. album subsp. abietis from Abies alba. Chemical analyses were performed through liquid chromatography coupled with high resolution mass spectrometry and Partial Least Squares Discriminant Analysis (PLS-DA) was performed in the Metaboanalyst 4.0. The antitumor potential of the selected VAE was evaluated in 2D and 3D models (MDA-MB-231 cancer cells) by MTT, crystal violet and glycolytic pathway analysis. Results and discussion: The first 3 principal components in PLS-DA explained 60% and 40% of data variation in positive and negative modes respectively. Three groups were formed and showed chemical similarity among V. album subspecies. The compounds responsible for group separation were tentatively identified as: pinobankasin or naringenin hexoside; isorhamnetin-3-hexoside, meglutol and different amino acids. The summer VAE at 0.5% v/v induced higher cytotoxic damage than the winter preparations, and Abies alba and Quercus sp. VAE promoted 49% and 42% reduction of tumor viability in 3D model (72h incubation), respectively. MDA-MB-231 glycolytic pathway in 2D model showed a decrease in the glucose consumption and extracellular lactate production. Also, PFK (6- phosphofructo-1-kinase) and PK (Pyruvate kinase) activities were inhibited by Abies alba and Quercus sp. VAE at 48h of incubation. Conclusion: VAE extracts showed different metabolomes and the glycolytic pathway should be an important target involved in the inhibition of tumor growth by these extracts.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1195
      Issue No: Vol. 21, No. 1 (2022)
       
  • NMR analysis: potential and challenges as a homeopathic basic research
           tool

    • Authors: Carla Holandino, Daniela Wendhausen Beier, Míriam Fragoso, Cintia Sias Coube Bastos, Vânia Emerich Bucco Campos, Adriana Passos Oliveira, Júlia Neves Santos, Lucas Henrique Silva, Ana Paula Canedo Valente
      Pages: 34 - 35
      Abstract: Background: Homeopathic ultra-diluted solutions surpass the threshold of matter dispersion and, consequently, their chemical constitution is similar to inert solvent. Nevertheless, randomized clinical trials have shown that the clinical effects of these homeopathic medicines are superior to placebo1. Nuclear magnetic resonance (NMR) is one of the most promising techniques to detect physicochemical alterations induced by homeopathic procedures2,3. Aims: To investigate T2 NMR relaxation times of Zincum metallicum and lactose dynamized samples. Methodology: Zincum metallicum samples were ground until 6dH using lactose as an excipient. Subsequently, these samples were dynamized with ultrapure water to produce 8dH, 9dH, 10dH, and 11dH. Lactose dynamized samples (6dH-11dH) were used as control. Aliquots of 540µl of each sample were diluted with 60µl of deuterated water (D2O) in 5mm tubes. The analyses were carried out in Bruker Ascend TM 500MHZ spectrometer at 288 K. Results and discussion: The Zincum metallicum and lactose T2 relaxation times were very similar, except for Zincum metallicum 8dH, which presented a value of 1.226 in comparison to 1.036 of lactose 8dH. The following T2 values were registered: 1.287 - 9dH; 1.413 - 10dH; 1.467 - 11dH, and 1.303 - 9dH; 1.400 – 10dH; 1.350 -11dH, for Zincum metallicum and lactose, respectively. The differences detected in 8dH samples are probably due to the presence of lactose in the first dilution step, in which 1 part of the 6dH triturated mixture was diluted in 9 parts of water, to prepare 7dH. Following this homeopathic procedure, 8dH solutions remain around 1% of lactose which could be influenced by the T2 values registered. Conclusion: These preliminary results showed the possibility to apply the NMR technique to evaluate the influence of dynamization in the relaxation parameters. Further studies should be carried out with other potencies and/or other homeopathic substances, in addition to the evaluation of T1 and the T1/T2 parameters, as previously described by other groups.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1202
      Issue No: Vol. 21, No. 1 (2022)
       
  • La Gioconda Effect, Homeopathy and Self-Organizing Factors of Biofield
           methodology

    • Authors: Silvio Leite Monteiro Silva
      Pages: 36 - 36
      Abstract: Background: The phenomenon of people’s attraction to Homeopathy throughout its history is a known fact by all homeopaths. This attraction is noted in polarization of people’s opinions, some for and some against. People in favor of Homeopathy use dynamized drugs and contribute to the area, for example, the development of the methodology Self-Organizing Factors of Biofield (BioFAO). In contrast, people against Homeopathy try to stop its use and feed endless discussions. Despite be aware of these events, there was no prior description about the whole process identified as an effect to make easy the development of an appropriate response. This understanding was published in a brief explanation of the phenomenon exemplified by development of BioFAO. Due to similar behavior of people that happened with another great work, which is a famous painting, the phenomenon was called La Gioconda Effect. Aims: The purpose of this paper is to describe the La Gioconda Effect. Methodology: After comparing both Homeopathy’s and Mona Lisa’s histories found at bibliographic review, the La Gioconda Effect was revealed, described qualitatively, and published. Results and discussion: The relationship between people with Homeopathy showed several similarities with people and Mona Lisa. Both works survived on a secular scale, influenced generations, have a period of social acceptance, many people show extreme interest in the use, education, research and dissemination of them. A remarkable example of the development of Homeopathy is the creation of BioFAO, which is a protocol with a complex of dynamized dugs. The description of La Gioconda Effect helps to understand the history and development of Homeopathy, as well as people's behavior. Conclusion: La Gioconda Effect demonstrates people's attraction to Homeopathy.
      PubDate: 2022-05-06
      DOI: 10.51910/ijhdr.v21i1.1184
      Issue No: Vol. 21, No. 1 (2022)
       
 
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