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  Subjects -> ALTERNATIVE MEDICINE (Total: 106 journals)
Showing 1 - 15 of 15 Journals sorted by number of followers
Journal of Palliative Medicine     Hybrid Journal   (Followers: 52)
Cognitive Neuroscience     Hybrid Journal   (Followers: 32)
Evidence-based Complementary and Alternative Medicine     Open Access   (Followers: 23)
International Journal of Qualitative Studies on Health and Well-Being     Open Access   (Followers: 21)
Complementary Therapies in Clinical Practice     Hybrid Journal   (Followers: 18)
Journal of Evidence-Based Integrative Medicine     Open Access   (Followers: 18)
BMC Complementary Medicine and Therapies     Open Access   (Followers: 17)
Journal of Manual & Manipulative Therapy     Hybrid Journal   (Followers: 17)
International Journal of Yoga     Open Access   (Followers: 17)
Complementary Therapies in Medicine     Hybrid Journal   (Followers: 16)
Acupuncture in Medicine     Hybrid Journal   (Followers: 16)
Journal of Bodywork and Movement Therapies     Hybrid Journal   (Followers: 16)
Journal of Alternative and Complementary Medicine     Hybrid Journal   (Followers: 14)
Focus on Alternative and Complementary Therapies     Hybrid Journal   (Followers: 12)
Alternative & Integrative Medicine     Open Access   (Followers: 10)
Journal of Dance Medicine & Science     Full-text available via subscription   (Followers: 10)
Australian Journal of Music Therapy     Full-text available via subscription   (Followers: 9)
Advanced Herbal Medicine     Open Access   (Followers: 8)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 8)
Journal of AYUSH :- Ayurveda, Yoga, Unani, Siddha and Homeopathy     Full-text available via subscription   (Followers: 8)
Journal of Ayurveda and Integrative Medicine     Open Access   (Followers: 6)
Alternative Medicine Studies     Open Access   (Followers: 6)
Asian Journal of Plant Pathology     Open Access   (Followers: 5)
Synfacts     Hybrid Journal   (Followers: 5)
Medical Acupuncture     Hybrid Journal   (Followers: 5)
Journal of Asian Natural Products Research     Hybrid Journal   (Followers: 5)
Fitoterapia     Hybrid Journal   (Followers: 5)
Journal of Drug Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Ayurveda Case Reports     Open Access   (Followers: 4)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 4)
Journal of Research in Ayurvedic Sciences     Open Access   (Followers: 4)
Journal of Acupuncture and Tuina Science     Hybrid Journal   (Followers: 4)
Chinese Medicine     Open Access   (Followers: 3)
Journal of Traditional and Complementary Medicine     Open Access   (Followers: 3)
Yoga Mimamsa     Open Access   (Followers: 3)
Journal of Natural Remedies     Open Access   (Followers: 3)
Journal of Herbal Science     Full-text available via subscription   (Followers: 3)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Ancient Science of Life     Open Access   (Followers: 3)
Integrative Medicine Research     Open Access   (Followers: 3)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
African Journal of Traditional, Complementary and Alternative Medicines     Open Access   (Followers: 3)
Journal of Ayurveda     Open Access   (Followers: 3)
Indian Journal of Ayurveda and lntegrative Medicine Klue     Open Access   (Followers: 3)
Arteterapia. Papeles de arteterapia y educación artística para la inclusión social     Open Access   (Followers: 3)
Journal of Applied Research on Medicinal and Aromatic Plants     Hybrid Journal   (Followers: 2)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
Australian Journal of Acupuncture and Chinese Medicine     Full-text available via subscription   (Followers: 2)
Innovare Journal of Ayurvedic Sciences     Open Access   (Followers: 2)
Journal of Integrative Medicine     Full-text available via subscription   (Followers: 2)
Deutsche Heilpraktiker-Zeitschrift     Hybrid Journal   (Followers: 2)
Research Journal of Medicinal Plant     Open Access   (Followers: 2)
Oriental Pharmacy and Experimental Medicine     Partially Free   (Followers: 2)
Alternative Medicine     Full-text available via subscription   (Followers: 2)
Journal of Herbal Medicine     Hybrid Journal   (Followers: 2)
Journal of Medicinally Active Plants     Open Access   (Followers: 2)
Journal of Ginseng Research     Open Access   (Followers: 1)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medicine and Culture     Open Access   (Followers: 1)
Muller Journal of Medical Sciences and Research     Open Access   (Followers: 1)
Médecine Palliative     Full-text available via subscription   (Followers: 1)
Journal of Medicinal Plants for Economic Development     Open Access   (Followers: 1)
South African Journal of Plant and Soil     Hybrid Journal   (Followers: 1)
Journal of Health Science and Alternative Medicine     Open Access   (Followers: 1)
Herbal Medicines Journal     Open Access   (Followers: 1)
Medicines     Open Access   (Followers: 1)
Journal of Fasting and Health     Open Access   (Followers: 1)
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
Indian Journal of Traditional Knowledge (IJTK)     Open Access   (Followers: 1)
Akupunktur & Aurikulomedizin     Full-text available via subscription   (Followers: 1)
Anales de Hidrología Médica     Open Access   (Followers: 1)
Journal of Applied Arts and Health     Hybrid Journal   (Followers: 1)
Journal of Herbal Drugs (An International Journal on Medicinal Herbs)     Open Access   (Followers: 1)
Zeitschrift für Orthomolekulare Medizin     Hybrid Journal   (Followers: 1)
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Erfahrungsheilkunde     Hybrid Journal   (Followers: 1)
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Integrative Medicine & Therapy     Open Access  
Journal of Complementary and Alternative Medical Research     Open Access  
Journal of Health Sciences Scholarship     Open Access  
World Journal of Traditional Chinese Medicine     Open Access  
Natural Volatiles & Essential Oils     Open Access  
Natural solutions     Full-text available via subscription  
Traditional Medicine Journal     Open Access  
World Journal of Acupuncture - Moxibustion     Full-text available via subscription  
Indian Journal of Research in Homoeopathy     Open Access  
Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi     Open Access  
Journal of Traditional Chinese Medical Sciences     Open Access  
Experimental and Therapeutic Medicine     Full-text available via subscription  
Nigerian Journal of Natural Products and Medicine     Full-text available via subscription  
Traditional & Kampo Medicine     Full-text available via subscription  
Research Journal of Pharmacognosy     Open Access  
Intas Polivet     Full-text available via subscription  
Global Journal of Traditional Medicine     Open Access  
Global Journal of Integrated Chinese Medicine and Western Medicine     Open Access  
Ipnosi     Full-text available via subscription  
OA Alternative Medicine     Open Access  
Herba Polonica     Open Access  
Journal of the Australian Traditional-Medicine Society     Full-text available via subscription  
International Journal of High Dilution Research     Open Access  
Revista Internacional de Acupuntura     Full-text available via subscription  

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Oriental Pharmacy and Experimental Medicine
Journal Prestige (SJR): 0.169
Number of Followers: 2  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 1598-2386 - ISSN (Online) 2211-1069
Published by Springer-Verlag Homepage  [2469 journals]
  • Biological properties of lemon basil seeds extract, legumes extract,
           sesame seeds extract and the inhibitory activity of the combination of
           lemon basil seeds extract with rice volatiles compounds against
           α-glucosidase, α-amylase and tyrosinase

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      Abstract: Abstract This research was conducted to evaluate the bioactive compounds content and biological activity of legume extract (mung bean (MB), job’s tears (JT), red kidney bean (RB) and black bean (BB)), sesame extract (white sesame (WS) and black sesame (BS)) and lemon basil seed extract (LB). The research also investigated the combined LB extract with kojic acid, acarbose and five rice volatile compounds against α-glucosidase, α-amylase and tyrosinase activity. The inhibitory activity of three enzymes and the extracts’ antioxidant capacity was closely related to the total phenolic and total flavonoid content. LB methanol extract (LB(ME)) had the highest total phenolic content, total flavonoid content and antioxidant capacity. LB water extract (LB(WE)) with the IC50 of 0.04 ± 0.004 and 0.14 ± 0.01 mg/mL had the highest inhibition potent against α-glucosidase and tyrosinase enzymes. In comparison, LB(ME) with the IC50 of 0.13 ± 0.01 mg/mL represented the highest inhibition potent on the α-amylase enzyme. Five rice volatile compounds with the α-glucosidase, α-amylase and tyrosinase inhibitory activity, low cytotoxicity and high anti-nitric oxide production were combined with LB extract to investigate the enzymatic inhibitory effect. The results indicated that LB(WE)/2-methoxy-4-vinylphenol and LB(WE)/2-pentyl furan had a synergic effect on α-glucosidase activity. We also investigated LB extract combined with acarbose and kojic acid against these enzymes. The results showed that LB(ME)/acarbose had the highest inhibition potent on α-glucosidase and α-amylase activity and LB(WE)/kojic acid had the highest on tyrosinase activity. Thus, these results suggest that using LB extract and the combined may be a useful therapeutic approach for diabetes and melanogenesis treatment.
      PubDate: 2022-09-28
       
  • Effectiveness and safety of Korean medicine for pain management after
           musculoskeletal surgery: a retrospective study

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      Abstract: Abstract To assess the effectiveness and safety of Korean medicine in managing postoperative pain. Retrospective, observational study. Medical records of 233 inpatients at a Korean medicine hospital who underwent Korean medicine treatments such as acupuncture, moxibustion, cuppping, bee-venom and herbal acupuncture, electrical therapy, herbal medicine, and carbon-beam therapy after musculoskeletal surgery were reviewed, and numeric ratings for pain were compared between baseline and follow-up. A correlation analysis between pain improvement and therapeutic factors was performed, and a regression analysis was conducted to determine the predictors of pain reduction. Serum laboratory test results at baseline and follow-up were subsequently compared to identify safety. Numeric rating scale scores for pain; presence of infection, drug-induced liver injury (DILI), and drug-induced kidney injury (DIKI) for safety. After Korean medicine treatment, the pain scores decreased from an average of 4.09 to 1.79 in the numeric rating scale (p < 0.001). Frequency of acupuncture therapy during hospitalization showed the strongest positive correlation with pain improvement (r = 0.341, p = 0.000) and was a predictor of pain reduction (adjusted R2 = 0.145). Improvements in serum laboratory data to reference limits were observed. All kappa coefficient values, except for white blood cell (WBC) count, were between 0.3 and 0.7, indicating that the follow-up data matched the baseline data. The low kappa coefficient value of WBC count was due to the high ratio of outliers. One (0.43%) and no cases of DILI and DIKI were identified, respectively. Korean medicine could be used for managing pain after musculoskeletal surgery.
      PubDate: 2022-09-27
       
  • Medicinal plants as potential therapeutic agents for trypanosomosis: a
           systematic review

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      Abstract: Abstract Trypanosomiasis is a neglected tropical disease caused by various trypanosome species that affects both humans and livestock with catastrophic implications across the endemic areas. Plants have been used for many centuries to establish or bring back health, well-being, and as cure for several illnesses. We performed a systematic review using the PRISMA guidelines to compile the results of studies carried out in both in vitro and in vivo investigations, examined the effect of plant extracts on trypanosomosis treatment and risk of bias of the studies. Published articles were appraised and only those with the requisite inclusion criteria looking at the efficacy of different medicinal plant extracts used against trypanosomosis globally from 1990 to 2020 in ScienceDirect, PubMed, SpingerLink, Scopus and Web of Science were used for this systematic review. A total of 761 medicinal plant species were evaluated for antitypanosomal activity with Fabaceae and Euphorbiaceae families being frequently studied. After comparative analysis, two plant species, namely, Khaya senegalensis and Terminalia superba produced best antitrypanosomal activity both in vitro and in vivo. Leaves (74%) and stem barks (38%) were most used plant parts. Medicinal plant extracts demonstrated in vivo antirypanosomal efficacy either singularly or synergistically at dosages < 2000 mg/kg, that resulted in elimination of parasitaemia and reduction of trypanosomosis clinical symptoms. On the other hand, most of the extracts, had an in vitro antirypanosomal activity within minutes after application in a concentration-dependent manner. Bias analysis showed the lack of standardized experimental designs and failures in statistical tests. There is lack of studies for evaluation of efficacy of medicinal plant extracts against Trypanosoma equiperdum and T. vivax both in vitro and in vivo amongst pathogenic trypanosomes. Medicinal plant extracts have potential therapeutic activity against pathogenic trypanosomes infecting animals and humans as suggested by majority of in vitro studies but require verification of in vivo efficacy and toxicity studies which are lacking.
      PubDate: 2022-09-20
       
  • Aqueous extract of Piper betle L. leaf and Areca catechu L. nut protects
           against pentylenetetrazole-induced seizures and positively modulates
           cognitive function in adult Zebrafish

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      Abstract: Piper betle L. (BL) is a popular medicinal plant in Asia. BL has been used as a traditional medicine to treat various health conditions. Areca catechu L. nut (AN) is an important traditional Chinese medicine, which has been used since antiquity. Epilepsy is a chronic neurological illness that affects millions of people. Cognitive dysfunction and abnormal behavior are the alarming co-morbidities of epilepsy. This study aims to investigate the anti-epileptic and cognitive improvement effects of Aqueous extract of Piper betle L. (AqEBL) and Aqueous extract of Areca catechu L. nut (AqEAN) against Pentylenetetrazole (PTZ) induced epilepsy associated cognitive dysfunction in adult Zebrafish (ZF). The extract was subjected to liquid chromatography coupled with tandem mass spectrometry analysis to identify its bioactive compounds. Further, molecular docking studies were carried out to understand the binding mode of various components of AqEBL and AqEAN within the active site of the gamma-aminobutyric acid receptor β3 subunit (GABAA subunit β3). The epilepsy-associated cognitive functions were assessed by behavioral studies including, seizure-score phenotype, T-maze, color recognition, and open field test; biochemical studies including brain antioxidant status and oxidative stress indices, acetylcholine esterase activity, neurotransmitters expression levels, and histopathology study in ZF model. It was evidenced in the current study that AqEBL and AqEAN have the potential to ameliorate seizure-like behavior through the GABAA receptor pathway and improve cognitive abilities. These data indicate that AqEBL and AqEAN may be potential options for epilepsy associated cognitive impairment. Graphical abstract
      PubDate: 2022-09-14
       
  • Effects of Alkanna bracteosa extract on the expression level of HSP90α
           and HER2 genes in human gastric cancer cell line

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      Abstract: Abstract Gastric cancer was classified as the third most deadly cancer among all other cancer types. The HSP90 and HER2 genes play essential roles in the stability and function of high-expression proteins that cause malignancy. The aim of this research was to investigate the influence of the alcoholic Alkanna bracteosa extract on the expression of HSP90α and HER2 genes in AGS cell line. Therefore, the methanolic extraction was isolated from aerial parts of the plant and AGS and HuGu cell lines were analyzed using 102.4–0.05 mg ml−1 dose concentrations in serial dilution; to measure the cell toxicity by MTT assay. Furthermore, real-time PCR analysis measured the expression level of HSP90α and HER2 genes using the IC50 dose concentrations. Quantification of apoptosis was analyzed by Annexin/PI kit in flow cytometry and DNA fragmentation tests. The results of MTT assay represented the IC50 dose concentration of 0.8 and 3.2 mg ml−1 for AGS and HuGu respectively. The rate of HER2 gene expression was significantly decreased in AGS cells treated with 0.8 mg ml−1 dose concentration compared to control. The exposure of AGS treated cells with 0.8 mg ml−1 dose concentration after 24 h represented 24.3% apoptosis and 13.3% necrosis. The agarose gel represented the DNA fragmentation pattern of apoptosis. This study demonstrated the significant differences between the cell viability rate, gene expression level, and apoptosis of the Alkanna bracteosa extract on AGS cells. These results demonstrated the first report of which the Alkanna braceteosa would be an effective candidate for possible treatment of Gastric cancer.
      PubDate: 2022-09-14
       
  • Correction to: Comparative local anaesthetic activity of lignocaine,
           lignocaine-adrenaline and water extracts of Annona muricata during
           castration in dogs

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      PubDate: 2022-09-13
       
  • Inferences of actinobacterial metabolites to combat Corona virus

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      Abstract: Abstract The entire globe is reeling under the magnitude of the current corona virus pandemic. This menace has proposed severe health and economic threats for all, thereby challenging our human existence itself. Since its outbreak, it has raised the concern and imperative need of developing novel and effective agents to combat viral diseases and now its variants as well. Despite the sincere and concerted efforts of scientists and pharma giants all over the world, there seems to be no ideal recourse found till date. Natural products are rich sources of novel compounds used in the treatment of infectious and non-infectious diseases. There are reports on natural products from microbes, plants and marine organisms that are active against viral targets. Actinobacteria, the largest phylum under the bacterial kingdom, is known for its secondary metabolite production with diverse bioactive potentials. Nearly 65% of antibiotics used in medicine are contributed by Actinobacteria. Compared to antibacterial and antifungal agents, antiviral compounds from Actinobacteria are less studied. In recent years Actinobacteria from under studied/extreme ecosystems are explored for their antiviral properties. Ivermectin and teicoplanin are examples of Actinobacteria-derived antiviral drugs available for commercial use. This review highlights the importance of actinobacteria as future sources of antiviral drug discovery.
      PubDate: 2022-09-13
       
  • Healing indigestion: a phytotherapeutic review

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      Abstract: Abstract Any abnormality in digesting food or lack of proper digestion is termed as indigestion. It refers to variety of gastrointestinal complaints, ranging from gas (belching or flatulence) to stomach upset. Common indigestion signs and symptoms are fullness, early satiety, nausea, vomiting, belching, bloating, ulcer, diarrhoea, dyspepsia and some other associated temporary discomforts or long lasting disorders. Treatment options are many which include change in food, drinks, lifestyle, synthetic medication, etc. But amongst all, the one by complementary and alternative medicines (CAMs), especially the time-tested phytotherapeutic traditional herbal remedies is gaining significance and reliance. Herbal medicinal plants and drugs therefrom are arguably the oldest forms of healthcare recognized to humanity and have been used by all cultures throughout history. Plants contain phytochemicals having specific as well as holistic biological functions, which may have a significant role in the treatment and prevention of various digestive disorders. The present review will address the indigestion issue as a common and universal discomfort to human being around the globe and also the magical healing options by some medicinal plants and herbals. With the remarkable surge of and reliance to the so-called CAM, it is imperative that the present and future researchers be aware of both the potential risks as well as the benefits of using herbal medicine in their cutting-edge exercise in the days ahead.
      PubDate: 2022-09-01
       
  • Cutaneous and systemic anti-allergic potential of xylopic acid in rodents

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      Abstract: Abstract Xylopic acid is a kaurene diterpene isolated from the dried fruit of Xylopia aethiopica. It has been identified to exhibit analgesic activity and also demonstrates acute and chronic anti-inflammatory activity. This study aimed at investigating its potential anti-allergic activity using rodent models. To investigate this, antihistaminic study using guinea pig ileum preparation and clonidine-induced catalepsy model were employed. Also, cutaneous anaphylaxis was investigated using pinnal inflammation and compound 48/80-induced cutaneous anaphylaxis models. Systemic anaphylaxis was studied using compound 48/80 systemic anaphylaxis and lipopolysaccharide (LPS)-induced septic shock models. XA exerted H1 antagonism in the ex vivo study using guinea pig ileum which supported its anti-histaminic activity in the clonidine-induced catalepsy. It also suppressed pinnal inflammation and inhibited mast cell degranulation and tissue damage significantly (P < 0.0001). In the systemic anaphylactic study, XA offered up to 90% survival rate in the compound 48/80-challenged mice and up to 70% protection against LPS-induced endotoxic shock at the studied doses. Xylopic acid showed histamine H1 receptor antagonism and subsequently inhibited clonidine-induced catalepsy. It inhibited passive cutaneous anaphylaxis, compound 48/80-induced anaphylaxis and the LPS-induced septic shock. These corroborate the cutaneous and systemic anti-allergic potential of XA in rodent allergy models.
      PubDate: 2022-09-01
       
  • Poisonous plants of Belize: a mini toxicological review

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      Abstract: Abstract The global increase in the use of plants for food and medicinal purposes, especially in developing countries, proffers an urgent need for toxicological studies on such plants. Results of extensive toxicological studies tend to provide safety information on toxic plants and help avert public health issues while providing safety guides to the public. Belize is a developing nation, and the only English-speaking country in Central America. More than half of the country is covered by rainforest, and many plants are consumed for food and medicinal purposes mostly without regard to the scientific toxicological characteristics of such plants. To the best of our knowledge, presently no published scientific toxicological reports exist on poisonous plants uniquely native to Belize. A careful bibliographic search was therefore conducted on published scientific reports applicable to plants native to Central America, and unpublished reports on poisonous plants of Belize to describe the toxicological information of such plants. A total of 16 plants from 7 families were identified to be toxic. The identified plants were reviewed for their toxicology. 13 plants were reported to be toxic, 2 plants were shown to be non-toxic, and no scientific studies were found for 1 plant. There is an urgent need to conduct toxicological research on plants native to Belize, especially that many such plants are used for food and medicinal purposes.
      PubDate: 2022-09-01
       
  • Medicinal use patterns of Parkia biglobosa (Jacq.) Benth. and Vitellaria
           paradoxa (Gaertn. F), two important traditional agroforestry species in
           Benin, West-Africa

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      Abstract: Abstract In West Africa, African locust bean (P. biglobosa (Jacq.) Benth.) and Shea (V. paradoxa (Gaertn. F) are among the most important multipurpose plant species commonly found in traditional agroforestry systems. Most of research on these species are dominated by patterns and properties of their food uses, and additionally cosmetics for the shea. Yet, the species also have interesting medicinal properties that have been little explicitly explored. Using an ethnobotanical survey, we explored the patterns of diseases and other human disorders healed by the species, the different plants parts involved in diseases treatment, the recipes adapted for the treatment of the diseases and disorders and the other species involved in recipes composition in Northern Benin where they are widely distributed and used. Plants parts used by respondents were subjected to a Principal Component Analysis together with the ethnic groups. Alpha diversity indices were used to compute disease diversity while the Intraspecific Use Values index was applied to assess the frequency of utilization of each plant part. Results showed that 11 categories comprising 51 diseases and disorders were listed by respondents for the two species, with the predominance of Gastro-intestinal diseases (RFC = 31.10% for P. biglobosa and RFC = 31.81% for V. paradoxa) and Infectious diseases (RFC = 26.82% for P. biglobosa and RFC = 27.27% for V. paradoxa). Most used plants parts were nuts (IVU = 90.90%) and roots (IVU = 90.90%) for V. paradoxa and roots (IVU = 90.24%) and bark (IVU = 70.73%) for P. biglobosa. The PCA analysis showed a strong variation in the used plants parts across the sociocultural groups.
      PubDate: 2022-09-01
       
  • In vitro antibacterial activity of Hibiscus rosa sinensis, Chrysanthemum
           indicum, and Calendula officinalis flower extracts against Gram negative
           and Gram positive food poisoning bacteria

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      Abstract: Abstract Safely management of food spoilage and foodborne illness is primarily achieved by applying chemical additives that have adverse effects along with health risk, increment chemical in food, and reduced bacterial susceptibility to antimicrobials. In the present study, antimicrobial efficacy of extracts from 3 different flowers (Hibiscus rosa sinensis, Chrysanthemum indicum, and Calendula officinalis) was examined towards seven food poisoning bacterial strains, four gram-positive strains (Staphylococcus aureus MTCC 87, Bacillus cereus MTCC 430, Clostridium perfringens MTCC 450, Listeria monocytogenes MTCC 657), and three gram-negative strains (Escherichia coli MTCC 43, Salmonella typhi MTCC 1264 and Pseudomonas aeruginosa MTCC424) using well diffusion assay. Aqueous extracts from all three of the flowers were similarly efficient with variable antimicrobial efficiency against the examined bacterial strains, while ethanol and methanol extracts from C. officinalis were highly efficient against all tested pathogenic bacteria. Ethanolic extract of C. indicum was the most efficient flower extract after C. officinalis against C. perfringens, L. monocytogenes, and S. typhi. H. rosa sinensis ethanol extract exhibited bactericidal action against S. aureus, B. cereus, and P. aeruginosa. For most extracts, the minimum inhibitory concentration (MIC) ranged from 3.75 to 7.5% and minimum bactericidal concentration (MBC) of 1.87–3.75% except for C. perfringens, and L. monocytogenes those were less sensitive with MIC 20%, and MBC 20%. Such flower extracts, which are potentially efficient, would be utilized to manage foodborne illness and protect food items from spoilage and minimize safety hazards generated due to chemically preservatives.
      PubDate: 2022-09-01
       
  • The Siddhars: the great artisans of gold medicines in medieval South India

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      Abstract: Abstract Gold, the king of metals, valued for its timeless beauty and properties, was known to the ancients as the metal of gods, a symbol of nobility of spirit, knowledge and meditation. To the alchemists, gold that never tarnishes was the metal of sun, giver of light and warmth. In Indian tradition, gold, a sacred metal, is seen as a “mineral light” capturing threads of brilliance in physical form. The metal is even consumed as an elixir to treat diseases and prepare the body and mind for spiritual journeys. The Siddhars (‘the perfected ones’), considered as saints and mystics in South India, played a vital role in alchemy, processing gold into a bioavailable form and formulating an important number of gold-based medicines such as thanga parpam, thanga chendooram, thanga kattu, thanga chunnam and other preparations. Due to the myths and legends surrounding the Siddhars and to the scarcity of the primary sources, many modern scientists looked at this medical system with some disdain and omitted to discuss its important achievements. In this work, it is our intention to fill in this gap and focus specifically on the gold-based Siddha medicines.
      PubDate: 2022-09-01
       
  • What is known about the medicinal potential of bamboo'

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      Abstract: Abstract Bamboos are considered one of China’s four noble plants and have been used for medicinal purposes for centuries. Despite that, what is really known about the chemical composition and biological activities of bamboos' Which species have been studied' What trials have been done to test their medicinal properties' This paper compiled studies of the last 11 years about phytochemical and biological activities of bamboos aiming a critical analysis of the results to provide perspectives and directions for future research using bamboo species as a potential source of drug leads. This review gathers available information on major scientific databases from the period of 2007–2018. A total of 136 papers regarding 87 bamboo species and 24 genera were compiled. Studies regarding phytochemical and or bioactivity of species from the Olyreae tribe (herbaceous bamboo) were not found. Phenolic compounds were the major class of secondary metabolites reported for bamboos species, followed by coumarins and alkaloids. Antioxidant capacity was the most performed bioassay. Phyllostachys has been the most studied genus. This review highlights a big lack of knowledge regarding American bamboos, mainly for the herbaceous species. Although bamboos are known to have a diversity of flavonoids, there are other classes of constituents that should be better studied. There are few bamboo species with their in vivo biological potential tested. Therefore, bamboos have economically important secondary metabolite classes with a possible medicinal application, but further studies on phytochemistry and in vivo assays are still needed to better evaluate their benefits to human health.
      PubDate: 2022-09-01
       
  • Bee venom phospholipase A2 ameliorates amyotrophic lateral sclerosis by
           increasing regulatory T cell population

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      Abstract: Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that primarily affects the nerve cells responsible for controlling voluntary muscle movement in the brain and spinal cord, causing loss of muscle control. Moreover, other researchers have reported that BV phospholipase A2 (bvPLA2) has neuroprotective effects in a mouse model of Alzheimer’s disease (AD). The aim of this study was to investigate whether bvPLA2 alleviates the pathological features of ALS by affecting Tregs in SOD1 mice. SOD1-G93A mice were used as the ALS model. The mice (75-days old) were administered phosphate buffered saline (PBS) or bvPLA2 (0.5 mg/kg) twice a week. The results demonstrated that the body and hindlimb weights of PBS-treated SOD1 mice were lower than those of wild-type mice, whereas that of bvPLA2-treated SOD1 mice increased compared to that of PBS-treated SOD1 mice. Motor function also decreased to a lesser extent in bvPLA2-treated SOD1 mice, whereas that of PBS-treated SOD1 mice was significantly impaired compared to wild-type mice. Moreover, bvPLA2-treated SOD1 mice had greater number of intact motor neurons in their lumbar spinal cord compared to PBS-treated SOD1 mice. The level of Tregs in the TA muscle was also higher in bvPLA2-treated SOD1 mice than in PBS-treated SOD1 mice. Lastly, bvPLA2-treated SOD1 mice showed less increase in levels of NOS2 and TNF-α and lower levels of IL-4 and IL-10 compared to PBS-treated SOD1 mice. Thus, our data suggest that bvPLA2 alleviates the progress of ALS by inducing a Treg-mediated anti-inflammatory response.
      PubDate: 2022-09-01
       
  • 8C-glycosylflavone from the Piper auritum suppressed glycoxidation process
           in vitro and in streptozotocin-induced diabetic mice

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      Abstract: Abstract Investigated the effects with C-glycosylflavone against the advanced glycation end-product (AGE) in vitro and in vivo. Chromatographic fractionation of the MeOH extract of P. auritum led to the isolation of the known 5,3′,4′-trihydroxy-7,8-dimethoxy-6-C-[β-D- xsylopyranosyl -(1 → 2)]-β-D-glucopyranosyl flavonoside (1). The structure was established on the basis of spectroscopic methods. Was investigate the effects of 1 against the advanced glycation end-product (AGE) in vitro and in vivo in a mice model of streptozotocin (STZ)-induced diabetes. Flavonoid significantly reduced the formation of fluorescent (AGEs, AOPPs), no fluorescent (Nε-CML), and fructosamine level in AGEs-BSA system. Its also avoided oxidation protein products, which was shown by reduction of protein carbonyl, and increase of thiol group, decreased the level of amyloid cross β-structure and suppressed the protein carbonylation in MGO-BSA model. Oral administration of 1 produced a significant decrease of serum glucose, inhibit the formation of GlyHb, prevented circulatory AGEs level, attenuated accumulation of AGEs in liver and kidney and reduced lipids accumulation possibly due to a better functioning of β-cell in diabetic mice. Finding, indicated that 1 can alleviating these parameters through diverse mechanisms with a marked antiglycation activity. Flavonoid participate in the initial and intermediate stages of glycation, leading to reduction of the production of AGEs in the late stage. Results indicated that 1 improving AGEs formation in type 2 diabetes.
      PubDate: 2022-09-01
       
  • Effects of aqueous extract of Anogeissus leiocarpus (DC) guill. Et Perr.
           

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      Abstract: Abstract Colitis are one of the worldwide increasing inflammatory bowel diseases. Colitis was induced by intrarectal administration of 1 mL of acetic acid (4%) in rats. The normal and the colitis controls treated with distilled water, the positive control treated with dexamethasone (5 mg/kg), and two test groups treated with extract at 100 and 200 mg/kg bw for seven days. During treatment, the number and quality of stools as well as changes in body weight and body temperature were assessed. At the end, animals were sacrificed; blood and colon were taken for the assay of oxidative stress, hematological and histological parameters. The diarrheal stools and the body temperature significantly (P < 0.01) decreased from the first to the sixth day of treatment compared to colitis control. The extract decreased significantly (P < 0.01) the number of gross colon lesions, malondialdehyde and nitric oxide levels in colon and in blood. The extract increased (P < 0.01) the levels of superoxide dismutase, glutathione, catalase, red blood cells, hemoglobin, hematocrit, total white blood cells as well as platelets. These could justify the use of Anogeissus leiocarpus in the treatment of inflammatory bowel diseases.
      PubDate: 2022-09-01
       
  • Properties of Solanum melongena green calyx against toxic effects of
           diabetes‐induced testopathy: a stereological and biochemical study

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      Abstract: Abstract Solanum melongena green calyx (SMGC) with antioxidant features seems to have many therapeutic features. Diabetes mellitus (DM) is a blood sugar disorder that increases oxidative stress levels in various types of cells leading to testopathy. In this study we aimed to investigate the protective functions of hydro-alcoholic extract of SMGC on DM‐induced testicular damages. Mature male rats were randomly divided into five groups (n = 8); 1: control, 2: diabetic, 3: diabetic + 100 mg/kg of SMGC, 4: diabetic + 300 mg/kg of SMGC, and 5: diabetic + 500 mg/kg of SMGC. Intraperitoneal injection of streptozotocin (STZ, a single dose of 60 mg/kg) was used for DM induction. Testicular alterations were evaluated quantitatively based on stereological techniques and followed by antioxidant enzymes determination (catalase, superoxide dismutase, and glutathione peroxidase), and serum testosterone level. Malondialdehyde and Bcl‐2 protein expression were also assessed biochemically. DM caused significant harmful changes in testicular structure, inhibition of antioxidant enzymes activity, decreased testosterone levels, and increased lipid peroxidation (LP). The expression of Bcl‐2 protein was down-regulated in DM testis along with boosted apoptosis rate. Eight weeks of SMGC treatment (particularly in high doses) recovered structural variations significantly, restored the power of the antioxidant defense system, and modified the testosterone levels. These findings revealed that the SMGC is considered as an effective antioxidant agent to decrease the adverse effects of DM on male reproductive system.
      PubDate: 2022-09-01
       
  • Bioactive compounds from Croton macrostachyus and Commiphora habessinica
           occurring in Ethiopia

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      Abstract: Croton macrostachyus is traditionally used in Ethiopia for treating diabetes, cancers, digestive problems, dysentery, wounds, fevers, constipation, diarrhea, intestinal worms, malaria, pain ulcers, and inflammation. The aim of the present work is investigating the chemical constituents of C. macrostachyus and Commiphora habessinica. The powdered stem bark of C. macrostachyus was successively extracted with n-hexane, chloroform and methanol yielding 1.2, 0.72 and 6.04% respectively. Phytochemical screenings of the extracts revealed the presence of flavonoids, tannins, saponins, phenols, terpenoids, glycosides, steroids and absence of anthraquinones. The methanol extract of C. macrostachyus subjected to chromatographic separation resulted in the antimalarial, antiprotozoal, antimicrobial, anti-inflammatory, antitumor and chemopreventive component lupeol (SED-1). The isolated compound was characterized using melting point, NMR and IR spectroscopy and by comparing experimentally obtained spectral data with previously reported literature. The essential oil of the resin from C. habessinica was isolated by hydro-distillation and a total of 21 components were identified by means of GC and GC/MS analysis. The main components of the essential oil were the medicinally important components α-copaene (27%), α-cadinol (25%), and trans-caryophyllene (15.3%). Graphical abstract
      PubDate: 2022-09-01
       
  • Sweat therapy, a novel treatment of psoriasis: prospective pre-post
           intervention design

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      Abstract: Abstract This study was conducted to confirm the potential of normal sweating as an important prognostic factor for the onset and treatment of psoriasis. A total of 97 patients who visited the Haeng-Pa Korean Medicine Clinic, a traditional Korean medical clinic for psoriasis, from January 2018 to October 2018 were enrolled in this prospective pre-post intervention study. Participants’ baseline characteristics, psoriasis state, seasonal and sweating factors, and treatment effects were analyzed with frequency analysis (%). All of 97 (100%) patients had problems with sweating in the psoriasis site and 50 (51.55%) patients had problems with sweating even in normal skin. 71 patients (73.20%) saw improvements from medicinal plants such as Ephedra sinica and Cinnamomi cassia Presl that promote perspiration. Psoriasis patients have problems with their sweating, and Korean medical sweat therapy was highly effective for treating psoriasis. Therefore, a sweating problem may be an important component in the onset and treatment of psoriasis.
      PubDate: 2022-06-23
      DOI: 10.1007/s13596-022-00645-3
       
 
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