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- Acupuncture regulates α-synuclein expression via serping1 in an
MPTP-induced mouse model of Parkinsonism-
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Authors: Min Hyung Seo; Sujung Yeo
Abstract: Acupuncture in Medicine, Ahead of Print.
Background:Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by a substantial loss of dopaminergic cells in the substantia nigra (SN) and the formation of intracellular Lewy bodies, which are mainly composed of α-synuclein (α-...
Citation: Acupuncture in Medicine
PubDate: 2025-03-25T12:03:56Z
DOI: 10.1177/09645284251327195
- Infectious pyogenic sacroiliitis following acupuncture: a series of three
cases and review of the literature-
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Authors: Yannick Laurent Tchenadoyo Bayala; Ismael Ayouba Tinni, Fulgence Kaboré, Wendlassida Joelle Stéphanie Zabsonré/Tiendrebeogo, Dieu-Donné OuedraogoRheumatology Department, Bogodogo University Hospital, Ouagadougou, Burkina Faso
Abstract: Acupuncture in Medicine, Ahead of Print.
Background:Acupuncture is an unusual cause of infectious sacroiliitis. Herein, we report three new cases of pyogenic sacroiliitis deemed to be attributable to acupuncture.Case 1:A 45-year-old male underwent 8 acupuncture sessions. He developed ...
Citation: Acupuncture in Medicine
PubDate: 2025-03-22T12:01:48Z
DOI: 10.1177/09645284251327200
- Electroacupuncture at 5/100 Hz alleviates neuropathic pain in rats by
inhibiting the CCL3/CCR5 axis in the spinal cord-
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Authors: Feng Wang; Zhihui Ye, Xiuju Yin, Chengcheng Zhou, Min Zhong, Gaofeng Zhao
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:Typically, neuropathic pain (NP) is difficult to manage as it is refractory to conventional medications. Electroacupuncture (EA) at 5/100 Hz has emerged as an effective and promising treatment for NP; however, its mechanism of action is still ...
Citation: Acupuncture in Medicine
PubDate: 2025-03-22T11:59:07Z
DOI: 10.1177/09645284251327197
- Electroacupuncture alleviates insulin resistance and impacts the
hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of
type 2 diabetes-
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Authors: Shuting Zhuang; Shaoyang Liu, Rui Li, Haoru DuanSchool of Acupuncture-Moxibustion Tuina, Beijing University of Chinese Medicine, Beijing, China
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:This study aimed to explore the effects of electroacupuncture (EA) in a rat model of type 2 diabetes mellitus (T2DM) by examining the hypothalamic miRNA-29a-3p, insulin receptor substrate (IRS)-1 / phosphatidylinositol 3-kinase (PI3K) / protein ...
Citation: Acupuncture in Medicine
PubDate: 2025-03-21T12:15:55Z
DOI: 10.1177/09645284251327205
- Dry needling in multiple sclerosis: a scoping review
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Authors: Abbas Tabatabaei; Farzan Molaei, Tobia Zanotto, Sharon G Lynch, Jacob Sosnoff
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:Dry needling (DN) has recently been investigated as an alternative strategy to reduce muscle spasticity and improve mobility in people with multiple sclerosis (pwMS). The aim of the present review was to identify any available literature on the ...
Citation: Acupuncture in Medicine
PubDate: 2025-03-21T12:12:44Z
DOI: 10.1177/09645284251327198
- Acupuncture treatment of postsurgical gastroparesis syndrome: a case
report-
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Authors: Xinyu Xia; Yan Liang, Napat Kongsirituwong, Qingcai Meng
Abstract: Acupuncture in Medicine, Ahead of Print.
Citation: Acupuncture in Medicine
PubDate: 2025-03-12T11:19:53Z
DOI: 10.1177/09645284251324528
- Acupuncture for symptom management in a case of severe cervical
ossification of the posterior longitudinal ligament-
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Authors: Guohui Zhou, Mingyang Wang, Mingpeng Shi, Zhenhua Li; Mingyang Wang, Mingpeng Shi, Zhenhua Li
Abstract: Acupuncture in Medicine, Ahead of Print.
Citation: Acupuncture in Medicine
PubDate: 2025-02-27T07:17:56Z
DOI: 10.1177/09645284251321857
- Electroacupuncture improves cognitive impairment after subarachnoid
hemorrhage in rats through the PI3K/AKT signaling pathway-
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Authors: Feng Zhou, Zhenzhi Wang, Kang Xiong, Xiaoman Fu, Hongru Jiang, Meiling Zhang, Qiang Wang, Yuan Wang; Zhenzhi Wang, Kang Xiong, Xiaoman Fu, Hongru Jiang, Meiling Zhang, Qiang Wang, Yuan Wang
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:Cognitive impairment (CI) is highly prevalent in subarachnoid hemorrhage (SAH) patients. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays a critical role in neuronal survival in a variety of central nervous system injuries. This study aimed to determine whether electroacupuncture (EA) at Yintang and LI20 ameliorates SAH-CI in a rat model and to examine whether it modulates the PI3K/AKT pathway by administering a PI3K inhibitor (LY294002) versus dimethyl sulfoxide (DMSO) vehicle.Methods:Notably, 129 male Sprague–Dawley rats were divided into Blank, Sham, SAH and SAH + EA groups (Experiment 1, n = 54) and SAH, SAH + EA, SAH + LY294002, SAH + EA + LY294002 and SAH + EA + DMSO groups (Experiment 2, n = 75). Garcia scoring was used to evaluate neurological function. The moisture content of the rat brain was determined by dry‒wet method. The Morris water maze was used to assess learning and memory function. Pathological changes in neurons in the hippocampus were observed via hematoxylin–eosin (H&E) staining. The number of surviving neurons and the percentage of apoptotic cells in the hippocampus were detected via Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. The expression of PI3K/AKT pathway-related proteins was detected via Western blotting.Results:The results indicated that EA intervention after SAH reduced brain water content, enhanced Garcia scores, improved neurological function and behavioral markers of CI, and increased the number of surviving neurons in the hippocampus. Moreover, EA significantly increased the expression of AKT, phosphorylated (p)-AKT, PI3K, p-PI3K, glycogen synthase kinase (GSK)-3β, p-GSK-3β and B cell lymphoma (Bcl)-2 proteins, and decreased the expression of Bcl-2-associated X (Bax) and caspase-3. In addition, the effects of EA were abolished by LY294002.Conclusion:EA appeared to improve CI in a rat model of SAH through the activation of the PI3K/AKT pathway.
Citation: Acupuncture in Medicine
PubDate: 2025-01-31T10:31:53Z
DOI: 10.1177/09645284251314187
- Practical and economic challenges of implementing group auricular
acupuncture treatment for chronic pain in primary care-
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Authors: Iman Majd, Daniel Cherkin, Masa Sasagawa; Daniel Cherkin, Masa Sasagawa
Abstract: Acupuncture in Medicine, Ahead of Print.
Background:Although growing numbers of patients seek acupuncture for pain management, few acupuncturists with insurance credentialing work in the conventional medical settings. This has resulted in increasing frustration among patients wishing to receive acupuncture in primary care settings as part of their insurance benefits.Methods:A course of eight weekly sessions of group auricular acupuncture (AA) for chronic musculoskeletal pain was implemented in a US primary care clinic and billed to insurance. The process of implementing group AA is described, including patients and researchers’ perceptions of their experience. We also examined various hypothetical scenarios for reimbursement based on relative value units (RVUs) based on Centers for Medicare and Medicaid (CMS) billing/coding.Results:Recruitment was greatly limited by COVID-19 requirements for social distancing and administrative hurdles, such that only four patients participated, three of whom attended all eight sessions. Seven additional Medicare patients were excluded due to concerns that acupuncture would not be covered. Participants reported mostly positive experiences with both AA and the group model of care. Based on our hypothetical reimbursement scenarios, in the fee-for-service model, group sessions appear to be economically more viable when staffed by non-physician acupuncturists credentialed for insurance reimbursement. For example, for a group of six patients each receiving acupuncture would be anticipated to generate 3.60 RVUs, whereas a physician seeing three individual patients consecutively for return office visits at CMS Evaluation and Management (E/M) level 3 could generate at least 4.11 RVUs.Conclusions:Offering group AA services in primary care clinics might increase access to acupuncture for patients with chronic pain. Although patients appreciated quicker access to acupuncture through group visits, and the group visit experience itself, logistical and economic barriers remain a challenge for sustainable group-based acupuncture visits.
Citation: Acupuncture in Medicine
PubDate: 2025-01-23T12:02:10Z
DOI: 10.1177/09645284251314188
- Electroacupuncture improves postoperative cognitive dysfunction by
inhibiting ferroptosis via the TFR1-DMT1-FPN pathway-
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Authors: Tianren Chen, Binsen Zhang, Xiaojia Zhang, Lu Tang, Chunai Wang; Binsen Zhang, Xiaojia Zhang, Lu Tang, Chunai Wang
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:The aim of this study was to investigate the role of ferroptosis in the occurrence of postoperative cognitive dysfunction (POCD) using a mouse model and to elucidate whether electroacupuncture (EA) can improve POCD by suppressing ferroptosis via the transferrin receptor 1 (TFR1)—divalent metal transporter 1 (DMT1)—ferroportin (FPN) pathway.Methods:The experiment involved three groups: the control group, the POCD group and the POCD + EA group. The POCD animal model was established using sevoflurane anesthesia and tibial fracture. Cognitive and behavioral changes in mice were assessed using the novel object recognition test (NORT) and the Morris water maze (MWM) test, 1 and 3 days after surgery. Transmission electron microscopy was performed to observe changes in the mitochondrial structure of hippocampal tissue. Enzyme-linked immunosorbent assay was conducted to determine the levels of glutathione (GSH) and iron ion (Fe) concentrations. Western blot analysis was used to measure the expression of TFR1, DMT1 and iron pump protein. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was employed to detect the mRNA levels of DMT1 and FPN.Results:Based on the experimental results of the MWM test and the NORT, we found that EA can improve POCD in mice. Observation by projection electron microscopy showed that EA improved the mitochondrial structure in the hippocampus. The enzyme-linked immunosorbent assay (ELISA) results showed that EA suppressed ferroptosis in the hippocampal area. The qRT-PCR and Western blot results suggested that EA suppresses ferroptosis by regulating the TFR1-DMT1-FPN pathway.Conclusion:This study reveals that sevoflurane and tibial fractures cause cognitive damage through the mechanism of ferroptosis, while EA may inhibit ferroptosis through the TFR1-DMT1-FPN pathway and improve POCD when induced in this way.
Citation: Acupuncture in Medicine
PubDate: 2025-01-04T09:40:32Z
DOI: 10.1177/09645284241302816
- Acupuncture for polymyositis: a case report
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Authors: Siqi Zhang, Liang Zhou, Guirong Dong, Hongsheng Dong, Chunling Bao; Liang Zhou, Guirong Dong, Hongsheng Dong, Chunling Bao
Abstract: Acupuncture in Medicine, Ahead of Print.
Citation: Acupuncture in Medicine
PubDate: 2025-01-02T11:22:21Z
DOI: 10.1177/09645284241307657
- Electroacupuncture induces analgesia by regulating spinal synaptic
plasticity via the AMPA/NMDA receptor in a model of cervical spondylotic
radiculopathy: secondary analysis of an experimental study in rats-
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Authors: Tian Wang, Hai-Yan Chen, Pu Yang, Xi Zhang, Sheng-Yong Su; Hai-Yan Chen, Pu Yang, Xi Zhang, Sheng-Yong Su
First page: 38
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:Cervical spondylotic radiculopathy (CSR) is characterized by neuropathic pain (NP). Although the analgesic effect of electroacupuncture (EA) has been widely recognized in clinical practice, the mechanism of EA in the treatment of CSR remains unknown. We previously reported that 7 days of EA improved behavioral markers of NP, attenuated increases in α-synuclein, synapsin 1 and 2, postsynaptic density (PSD)-95 and growth-associated protein (GAP)-43, and improved ultrastructural changes within synapses in a rat model of CSR. Herein, we present supplemental data from the same cohort of animals examining the timing of behavioral improvement within the first week (through additional measurements at 3 and 5 days into the EA treatment) and new data on the effects of EA on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and N-methyl-d-aspartic acid receptor (NMDAR) levels.Methods:As previously reported, the rats were divided into four groups at random: normal, sham, CSR and CSR + EA. EA at bilateral LI4 and LR3 was administered once a day for 7 days (20 min each) in the CSR + EA group after the CSR model was established by inserting a fishing line under the laminae. Behavioral assessments were carried out prior to initiation of EA and at 3, 5 and 7 days into the 7-day treatment course. Concentrations ofγ-aminobutyric acid (GABA) and glutamate (Glu) were determined using enzyme-linked immunosorbent assay and ultraviolet colorimetry, respectively, and AMPAR (glutamate receptor (GluR)1 and GluR2 membrane protein) expression was determined using Western blotting. Immunohistochemistry was used to detect the protein expression and average optical density (AOD) of NMDAR1 (NR1), NMDAR2A (NR2A) and NMDAR2B (NR2B). Quantitative reverse transcription-polymerase chain reaction was used to detect the mRNA expression of NR1, NR2A and NR2B. Transmission electron microscopy was used to observe changes in synaptic ultrastructure.Results:EA significantly improved the pressure pain threshold (PPT) and mechanical withdrawal threshold (MWT) 5 days into the intervention, although effects were less pronounced than at 7 days (at completion of treatment). However, significant effects on gait scores were not seen prior to 7 days. As previously reported, EA also improved markers of synaptic ultrastructure. In the spinal cord, GluR1 membrane protein expression was decreased, GluR2 membrane protein expression was increased, and the GluR1/GluR2 ratio was decreased. Protein and mRNA expression of NR1, NR2A and NR2B was significantly decreased. GABA concentration was markedly increased, while Glu concentration was markedly decreased.Conclusion:Evidence of EA analgesia (higher PPT and MWT scores) was seen after 5 days of EA, while positive effects on motor function required 7 days of treatment. The underlying mechanism may be related to inhibition of AMPAR and NMDAR expression, regulation of the concentration of related neurotransmitters and improvement of spinal cord synaptic plasticity. This study establishes a preliminary theoretical foundation for the use of EA in the clinical treatment of CSR.
Citation: Acupuncture in Medicine
PubDate: 2025-02-03T08:39:47Z
DOI: 10.1177/09645284251314189
- Electroacupuncture pretreatment at ST36 alleviates acute gastric mucosal
lesions induced by water immersion restraint stress through the
TRPV1/SP/CGRP/NO pathway in rats-
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Authors: Qun Jiang, Mingyan Guo, Lingsong Guo, Qiong Ling, Chuangbo Xie, Xiangyu Li, Gaofeng Zhao, Weifeng Tu; Mingyan Guo, Lingsong Guo, Qiong Ling, Chuangbo Xie, Xiangyu Li, Gaofeng Zhao, Weifeng Tu
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:The aim of this study was to determine the impact of electro-acupuncture (EA) pretreatment on the progression of acute gastric mucosal lesions (AGMLs) induced by water immersion restraint stress (WIRS) and explore the related mechanisms including the transient receptor potential vanilloid (TRPV)1 signaling pathways.Methods:Rats treated with EA for 4 days were subjected to WIRS for 6 h. Microscopic lesions, oxidative stress and TRPV1, substance P (SP), calcitonin gene-related peptide (CGRP) and nitric oxide (NO) levels in the dorsal root ganglion (DRG) and gastric tissues were detected.Results:The results indicated the development of AGMLs with a substantial increase of TRPV1/SP in the DRG and TRPV1/SP/MDA (malondialdehyde activity) in the stomach, and a significant decrease in CGRP/NO/SOD (superoxide dismutase) in gastric tissues, using a combination of real-time reverse transcription polymerase chain reaction, Western blotting and enzyme-linked immunosorbent assay.Conclusion:The TRPV1 signaling pathways likely play an important role in the pathogenesis of AGML. In addition, EA pretreatment protected gastric mucosa lesions induced by WIRS by reducing the expression of TRPV1/SP in the DRG and gastric mucosa, as well as up-regulating gastric CGRP/NO. Antioxidant mechanisms are likely to at least partially mediate the protective effects of EA against AGML.
Citation: Acupuncture in Medicine
PubDate: 2024-12-31T12:00:51Z
DOI: 10.1177/09645284241300177
- Involvement of the astroglial glutamate–glutamine cycle in the analgesic
effects of electroacupuncture in a rat model of chronic neuropathic pain-
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Authors: Hao-Han Zhu, Xing-Ke Song, Jian-Liang Zhang, Jin-Ling Zhang, Pei-Jing Rong, Jun-Ying Wang; Xing-Ke Song, Jian-Liang Zhang, Jin-Ling Zhang, Pei-Jing Rong, Jun-Ying Wang
Abstract: Acupuncture in Medicine, Ahead of Print.
Objective:Our previous study found that astrocytes are involved in cumulative analgesia; however, the underlying mechanism remains unclear. The aim of this study was to further explore the potential role of astrocytes in the effects of electroacupuncture (EA) on neuropathic pain by focusing on the glutamate–glutamine cycle.Methods:69 male Sprague–Dawley (SD) rats were randomly divided into a normal control group, untreated chronic constriction injury (CCI) model group and EA-treated model (CCI + EA) group. EA was applied bilaterally at ST36 and GB34. Pain thresholds were assessed using behavioral tests and thermal stimuli. We examined the co-expression of glutamate/aspartate transporter (GLAST) via immunofluorescence and measured the expression levels of GLAST, glutamate transporter (GLT)-1 and glutamine synthetase (GS) using Western blotting and polymerase chain reaction (PCR). Glutamate (Glu) and gamma-aminobutyric acid (GABA) levels were detected by high-performance liquid chromatography (HPLC). To validate the impact of GLAST/GLT-1 in the analgesic effect of EA, an additional 30 SD male rats were divided into groups receiving intrathecal saline, GLAST antagonist or GLT-1 antagonist alongside EA.Results:Post-CCI, pain thresholds were decreased, GLAST expression was diminished, and spinal Glu levels were increased. EA treatment reversed these effects, improved pain thresholds and GLAST/GLT-1 expression in astrocytes, and reduced Glu levels. Antagonist administration negated the analgesic effects of EA.Conclusion:Repeated EA administration inhibited CCI-induced chronic neuropathic pain in rats, corresponding to a reversal of decreased expression of GLAST and GLT-1, which may have accelerated the clearance of Glu and thereby reduced its concentration. Regulation of the astroglial glutamate–glutamine cycle is a potential target of EA.
Citation: Acupuncture in Medicine
PubDate: 2024-12-31T05:29:41Z
DOI: 10.1177/09645284241309952
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