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- Assessment of Incomplete Apical Bone Coverage of Maxillary Premolar and
Molar Roots Using Cone Beam Computed Tomography in 161 Dogs-
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Authors: Colin Dick Abstract: Journal of Veterinary Dentistry, Ahead of Print. This retrospective study assessed maxillary premolar and molar teeth and identified roots with incomplete apical bone coverage using cone beam computed tomography in 161 dogs. The associated dorsal anatomic sites that the roots communicated with were the ventral nasal meatus, maxillary recess, infraorbital canal, and pterygopalatine fossa. The study found that all roots of the maxillary premolar and molar teeth have the potential for incomplete apical bone coverage, with 26.7% having incomplete apical bone coverage. No significant association with sex was found. A significant association with weight was found, and this lowered with increasing body weight. Facial index, as a determinate of skull shape, was found to be significant in only 35.7% of roots in univariate and 14.2% of roots in multivariate modeling. Knowledge of the anatomy of these roots plays an important role in safe and effective extraction techniques, in reducing iatrogenic trauma, and in understanding the potential local effects of periodontal and endodontic disease. Citation: Journal of Veterinary Dentistry PubDate: 2024-08-07T01:24:46Z DOI: 10.1177/08987564241268903
- Unleashing the Power of Collaboration: The Invaluable Role of Veterinary
Dental Technicians-
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Authors: David E. Clarke Abstract: Journal of Veterinary Dentistry, Ahead of Print.
Citation: Journal of Veterinary Dentistry PubDate: 2024-07-26T10:43:55Z DOI: 10.1177/08987564241266378
- Biomechanics of Dental Implantation in the Giant Panda (Ailuropoda
melanoleuca): A Comparative Study Using Finite Element Analysis-
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Authors: Han Long, Huimin Zhang, Linhua Deng, Caiwu Li, Yan Zhu, Shanshan Ling, Desheng Li, Xiaoxiao Zhou, Haifeng Liu, Zhijun Zhong, Guangneng Peng, Chengdong Wang, Ziyao Zhou Abstract: Journal of Veterinary Dentistry, Ahead of Print. Giant pandas have a high incidence of tooth wear, loss, and fracture since their diet is specifically bamboo. Dental implantation is a common treatment for tooth loss in humans while rarely reported in wild animals. To explore the applicability of dental implantation in giant pandas, this study measured mandible parameters of the giant panda, from an adult skeletal specimen. The mandible bone block model was developed using computer-aided design 3D mechanical drawing software. Implants of different radius and thread types of the third premolar tooth (PM3) were assembled and imported into an analysis software system for finite element analysis. As a result, the reverse buttress implant with a radius of 7.5 mm and 8.3 mm, and a length of 15 mm was found to be the most suitable implant for use in the giant panda PM3. This study provides a reference for appropriate clinical giant panda dental implantation, although, the feasibility of giant panda dental implantation needs to be studied further. Citation: Journal of Veterinary Dentistry PubDate: 2024-07-23T08:42:38Z DOI: 10.1177/08987564241265420
- Severe Bilateral Sialadenitis of the Mandibular and Parotid Salivary
Glands with Severe Panniculitis in a 2-Year-old Standard Poodle-
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Authors: Deborah E. Yee, Joseph Cyrus Parambeth, Lukas Kawalilak, Christopher Sauvé Abstract: Journal of Veterinary Dentistry, Ahead of Print. A 2-year-old male neutered Standard Poodle weighing 17.9 kg was presented to their primary care veterinarian for enlarged bilateral submandibular swellings following an interdog altercation sustained in the previous weeks. Cytology performed following fine-needle aspirates of the regions of swelling was inconclusive, and the patient was treated empirically with Clavaseptin. Despite treatment, the submandibular swellings continued to enlarge, and right-sided intermittent epistaxis was reported. On biochemical profile, there was mild hypercalcemia and mild hyperglobulinemia. The computed tomography (CT) findings were indicative of severe multifocal sialadenitis with severe regional cellulitis and inflammatory lymphadenopathy. Histopathology and cytology results described mixed inflammation of the salivary gland. Methenamine silver staining and Fite's acid-fast staining were negative. Aerobic and anaerobic cultures were negative. Targeted, next-generation DNA sequencing detected no known fungi or bacterial pathogens. These findings were consistent with the diagnosis of severe bilateral mandibular sialadenitis, panniculitis, and lymphadenopathy. The patient was prescribed enrofloxacin, clindamycin, phenobarbital, and prednisolone for 1 month. One week after initiating treatment, the patient had a significant reduction in size of the salivary glands. CT imaging was helpful in the diagnosis of this patient and allowed the clinician to identify which submandibular anatomical structures were abnormal, guiding subsequent diagnostic decisions to provide medical management to resolve the condition. Citation: Journal of Veterinary Dentistry PubDate: 2024-07-23T08:41:38Z DOI: 10.1177/08987564241264462
- Effect of Pulp Chamber Access, Instrumentation, Obturation, and
Restoration on the Fracture Resistance of Endodontically Treated Canine Teeth in Dogs-
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Authors: Maya Alexandra Popovic, Bertrand Lussier, Kambiz Chizari, Yvan Dumais Abstract: Journal of Veterinary Dentistry, Ahead of Print. Veterinary studies documenting the effect of endodontic treatment on tooth fracture resistance are scarce. The objective of this ex vivo study was to evaluate the effects of mesial access preparation and restoration, as well as pulp chamber access, instrumentation, obturation, and restoration, on the fracture resistance and characteristics of canine teeth in dogs. Sixty-five dog canine teeth were divided into 4 groups: 1. Standard endodontic treatment through a mesial access only; 2. Treatment as per group 1, adding an incisal access, instrumentation and obturation of the pulp chamber, and restoration of the access; 3. Treatment as per group 2, without pulp chamber obturation or restoration of the incisal access; and 4. Untreated teeth. The fracture resistance and characteristics of each group were documented using axial compression testing, angled 45° disto-occlusal to the long axis of the crown. The maximum force prior to fracture in groups 1, 3, and 4 were not statistically different, demonstrating that restored mesial and incisal accesses with pulp chamber instrumentation did not statistically affect fracture resistance. However, obturated and restored group 2 teeth demonstrated decreased fracture resistance compared to all other groups (P Citation: Journal of Veterinary Dentistry PubDate: 2024-07-23T08:41:18Z DOI: 10.1177/08987564241264036
- Gingival Mucoperiosteal Fibroma—Clinical, Imaging, and Histological
Review of a Novel Oral Fibroma in 27 Dogs-
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Authors: Joyce Tai, Cynthia M Bell Abstract: Journal of Veterinary Dentistry, Ahead of Print. This case series describes the clinical, imaging, and histological features of 27 lesions diagnosed as a benign fibrous mass not previously described in veterinary literature. The authors propose the name gingival mucoperiosteal fibroma (GMPF) to describe these fibrous lesions found in dogs. Histologically, GMPF is characterized by a lack of odontogenic tissue and various degrees of ossification. GMPFs affect adult dogs with an average age of 95 months (range 24-156 months) and appear as expansile growths with superficial appearance matching the surrounding gingiva. The mandibular incisive region is the most commonly affected region (n = 13) and most cases have some level of bone proliferation radiographically (n = 14). Histological examination of the masses shows poorly cellular fibrous tissue with thick interwoven collagen fibers. Bony invasion by the mass was not noted, though histological proliferation of bone was seen in 17 lesions. Surgical resection was curative in all cases when performed, and no recurrence was seen at time of follow-up. Fibrous lesions of the oral cavity in dogs are poorly defined and categorized, though numerous lesions have been described in both human and veterinary literature. Citation: Journal of Veterinary Dentistry PubDate: 2024-07-23T08:40:59Z DOI: 10.1177/08987564241263981
- Effectiveness of a Daily Honeycomb-Shaped Dental Chew in Reducing
Calculus, Plaque, Gingivitis and Malodor in Dogs-
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Authors: Susan E. Crowder, Mary Berg, Jan Bellows, Marjory Artzer, Scott MacGee, Loren Schultz Abstract: Journal of Veterinary Dentistry, Ahead of Print. Periodontal disease in dogs is common. Client compliance with oral hygiene and oral care for pets is low. The gold standard is annual dental prophylaxis under general anesthesia with imaging followed by home care including daily brushing. Clients should be offered methods to reduce calculus, plaque, gingivitis, and resulting halitosis that are time efficient, cost-effective, and easy to administer between annual preventative dental prophylaxis with the goal to move into maintenance phase of managing periodontal disease. This study aimed to evaluate the efficacy of a honeycomb-shaped dental chew in reducing hardened calculus, plaque, gingivitis, and malodor in client-owned dogs in their normal home environment including various breeds, skull types, ages, and weights. Calculus, plaque, and gingival scores with volatile sulfur compounds readings were performed under sedation and evaluated under general anesthesia after 60 consecutive days of receiving a daily honeycomb-shaped dental chew treat. There was an overall statistically significant percentage reduction of calculus (26.6%), plaque (14.2%), and malodor (46.71%). Gingival scores did not demonstrate statistically significant reduction (0.99%). Use of this honeycomb-shaped daily dental chew significantly reduced calculus, plaque, and associated malodor in dogs when fed consecutively for 60 days. Citation: Journal of Veterinary Dentistry PubDate: 2024-05-31T02:28:07Z DOI: 10.1177/08987564241255043
- A Combined Ventral Extraoral and Intraoral Approach for Mandibulectomy in
9 Cats: A Case Series-
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Authors: Alessandro De Simoi, Paola Marchese, Francesca Bartocetti Abstract: Journal of Veterinary Dentistry, Ahead of Print. This retrospective case series describes a combined ventral extraoral and intraoral approach for mandibulectomy in cats and highlights the importance of prompt management of the postoperative iatrogenic malocclusion through dental extraction, crown height reduction with vital pulp therapy or root canal therapy of the contralateral mandibular canine tooth. Nine cats were reviewed for signalment, history and physical examination, diagnostic workup, tumor type, mandibulectomy extension, lymph node removal as well as both intraoperative and postoperative complications. The performed surgical procedure was a combination of an extraoral approach ventrally to the mandible and an intraoral approach to remove the whole or a part of the mandible. Lymphadenectomy was achieved using the same surgical access. None of the cats had intraoperative complications. Postoperative complications were limited to regional swelling and drooling lasting a week. Seven cats were able to eat immediately after the surgery. Of the other 2 cats, 1 regained the ability to eat within a month and 1 only ate from the owner's hands. The surgical approach for mandibulectomy described allowed better access and visualization of the caudal part of the mandible and direct access to regional lymph nodes. Moreover, if the expected postoperative malocclusion is managed during the same surgical procedure, there is a higher rate of postoperative eating ability compared to what is reported in the literature. Citation: Journal of Veterinary Dentistry PubDate: 2024-05-22T12:51:48Z DOI: 10.1177/08987564241255292
- Medially Positioned Single Mucoperiosteal Flap With and Without Allograft
Membrane for Repair of Congenital Cleft Palate in 4 Dogs-
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Authors: Kevin Haggerty,
Lorraine Hiscox, John Lewis Abstract: Journal of Veterinary Dentistry, Ahead of Print. Congenital cleft of the secondary palate occurs when there is failure of one or both maxillary processes to fuse with the nasal septum during embryonic development. Palatal cleft severity can range from a simple focal fissure of the caudal soft palate to full-thickness defects of varied widths involving the entire soft and hard palate. A novel staged medially positioned single mucoperiosteal flap technique in 4 canine patients is reported. This flap technique is based on the major palatine and infraorbital arteries with strategic extractions of maxillary teeth and placement of allograft membrane in 3 of 4 cases for treatment of clefts wider than may be repaired effectively by traditional methods. Citation: Journal of Veterinary Dentistry PubDate: 2024-05-22T12:51:29Z DOI: 10.1177/08987564241255049
- The Thomas P. Sollecito One Health Fellowship in Oral Medicine
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Abstract: Journal of Veterinary Dentistry, Ahead of Print.
Citation: Journal of Veterinary Dentistry PubDate: 2024-05-16T07:23:13Z DOI: 10.1177/08987564241255205
- Instructions for Authors - JOVD
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Abstract: Journal of Veterinary Dentistry, Ahead of Print.
Citation: Journal of Veterinary Dentistry PubDate: 2024-05-15T02:05:09Z DOI: 10.1177/08987564241249313
- Editorial: Embracing the Future With Optimism in Veterinary Dentistry
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Authors: Barden Greenfield Abstract: Journal of Veterinary Dentistry, Ahead of Print.
Citation: Journal of Veterinary Dentistry PubDate: 2024-05-07T05:49:28Z DOI: 10.1177/08987564241249315
- A Computed Tomographic Study of the Molar Teeth of Babyrousa spp.
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Authors: Alastair A. Macdonald, Bianca Ziehmer, Andrew C. Kitchener, Magnus Gelang, Björn Åblad, Ruth Lintonsson, Kerstin von Pückler, Sebastian Schaub, Ingmar Kiefer, Tobias Schwarz Abstract: Journal of Veterinary Dentistry, Ahead of Print. A photographic and computed tomography (CT) scanning study was carried out on 295 molar teeth of 18 adult male Babyrousa babyrussa skulls and 8 skulls of Babyrousa celebensis including seven adult males and one adult female. The occlusal morphology of the permanent maxillary and mandibular molar teeth of B. babyrussa was very similar to that of B. celebensis. Most B. babyrussa maxillary molar teeth had six roots, with small numbers of teeth having four, five or seven roots. A similar pattern was suggested in B. celebensis. Mandibular molar teeth had between four and eight roots. Tooth roots of maxillary and mandibular first and second molar teeth were largely tapering, rod-like structures. The roots of the right and left maxillary third molar teeth had a more complex arrangement; some were inserted almost vertically into the maxilla; others were orientated in a more distal direction. The mesial and distal roots were splayed in appearance. The right and left mandibular third molar tooth roots retained elements of the open ‘C’ shape and were generally orientated distally. The pulp chambers were arched to fit under the main cusps in all molar teeth. Pulp canals were variable in number. Citation: Journal of Veterinary Dentistry PubDate: 2024-05-06T05:05:04Z DOI: 10.1177/08987564241248818
- Saliva Malondialdehyde Concentration of Dogs With and Without Periodontal
Disease-
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Authors: M. Schroers, K. Reiser, T. Alexander, Y. Zablotski, A. Meyer-Lindenberg Abstract: Journal of Veterinary Dentistry, Ahead of Print. The study investigated whether malondialdehyde (MDA), a biomarker for oxidative stress, can be used as a viable parameter in dog saliva for the diagnosis or early detection of periodontal disease (PD). Saliva MDA concentrations were measured preoperatively in dogs diagnosed with PD during dental prophylaxis and compared with those of dentally healthy dogs. 35 dogs were included in the study. The average MDA concentration was 270 ng/ml (range 27-633) in the dogs without PD (n = 10) and 183 (36-833) ng/ml (ng/ml) in the dogs with PD (n = 25). The maximum MDA concentration in the study group (PD ≥1) was 833 ng/ml, which was significantly higher than in the study group (PD = 0) (p Citation: Journal of Veterinary Dentistry PubDate: 2024-05-02T06:41:26Z DOI: 10.1177/08987564241248042
- We're sharing the top-read articles from Journal of Feline Medicine and
Surgery-
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Abstract: Journal of Veterinary Dentistry, Ahead of Print.
Citation: Journal of Veterinary Dentistry PubDate: 2024-04-29T02:57:55Z DOI: 10.1177/08987564241249311
- Treatment of an Infrabony Defect of a Maxillary Canine Tooth Using Enamel
Matrix Derivatives with Allogeneic Bone Augmentation in a Dog-
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Authors: Se Eun Kim, Gahyun Lee Abstract: Journal of Veterinary Dentistry, Ahead of Print. A 5-year-old Miniature Dachshund was presented having an infrabony pocket on the palatal aspect of the right maxillary canine tooth. The bony defect had worsened despite previous closed root planing and administration of a perioceutic agent. A second surgery using an allogeneic cancellous bone augmentation with an enamel matrix derivative was performed in the infrabony defect following open root planing. Eight months after the periodontal surgery, the osseous defect showed healing by improved periodontal probing measurements and increased radiopacity using dental radiography and computed tomography. Citation: Journal of Veterinary Dentistry PubDate: 2024-04-22T08:04:40Z DOI: 10.1177/08987564241246683
- Adjunctive Use of Hyperbaric Oxygen Therapy in Veterinary Dentistry and
Oral Surgery: A Case Series-
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Authors: Melanie Hunt, Danielle Mendelsohn, Katherine Queck, Carlos Rice Abstract: Journal of Veterinary Dentistry, Ahead of Print. Hyperbaric oxygen therapy (HBOT) is utilized as an adjunctive treatment for human and veterinary patients with compromised tissues. Medical records from two veterinary hospitals with HBOT chambers were searched for small animal veterinary dentistry and oral surgery specialty patients. The HBOT records were combined with the medical records from the referring specialty veterinary dentistry and oral surgery services. Clinical indications for HBOT treatments associated with a positive outcome in this case series included resistant bacterial infections, electrical cord injury, bite wound injuries, osteomyelitis, crush/traumatic injuries including mandibular fractures, oral surgery performed at previously irradiated sites, and osteonecrosis, presumably radiation induced. Conditions within this case series that remained unchanged or were associated with partial improvement included preoperative treatment of stomatitis without steroid usage and delayed HBOT treatment for long-term endodontic health of laterally luxated immature permanent mandibular incisors. Eighty-eight percent of the HBOT sessions were tolerated well by the patients in this case series. The most common adverse event was mild anxiety. One patient required oral anxiolytic medications to complete the course of treatment. One patient experienced transient seizure activity and was able to complete that session as well as subsequent sessions at a lower chamber pressure. Future prospective studies are necessary to further evaluate and characterize the potential benefits of HBOT as well as to clarify optimal treatment protocols for specific conditions in veterinary dentistry and oral surgery. Citation: Journal of Veterinary Dentistry PubDate: 2024-03-22T07:17:20Z DOI: 10.1177/08987564231225854
- Effects of Coriander on the Repair Process of Experimentally-induced
Periodontitis in Rats-
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Authors: Umut Ballı, Şeyma Bozkurt Doğan, Figen Öngöz Dede, Kanat Gülle, Hatice Çölgeçen, Bahattin Avcı, Meryem Akpolat Ferah, M. Bülent Kurtiş Abstract: Journal of Veterinary Dentistry, Ahead of Print. The aim of this study was to evaluate the effects of Coriandrum sativum L. (CSL) seed extract on gingival levels of antioxidant enzymes, pro-inflammatory cytokines and on alveolar bone and attachment levels after experimental periodontitis induction in rats and compare it with low-dose doxycycline (LDD). Forty adult male Wistar Albino rats were divided randomly into 5 groups as follows: 1 = periodontally healthy (control); 2 = periodontitis; 3 = periodontitis + CSL (32 mg/kg); 4 = periodontitis + CSL (200 mg/kg); and 5 = periodontitis + LDD (6 mg/kg). Gingival superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) levels were evaluated by enzyme-linked immunosorbent assay. The presence of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1βeta (IL-1β) immunoreactivity was detected immunohistochemically. Alveolar bone area in the furcation space (ABA), alveolar bone loss (ABL), and attachment loss (AL) were evaluated histomorphometrically. The SOD level was lower in group 5 than in groups 2, 3, and 4. The IL-1β level was highest in group 4. The TNF-α level was statistically higher in groups 2 and 4 than in groups 1, 3, and 5. The IL-6 level was highest in group 4. Its level was higher in groups 2 and 3 than in group 5. ABA was less in groups 2, 3, and 4 compared to groups 1 and 5. ABL was less in group 5 than in groups 2, 3, and 4. AL was greater in group 4 than in group 5. The use of 200 mg/kg CSL showed a pro-inflammatory effect and IL-1β and TNF-α levels decreased after 32 mg/kg CSL application in the treatment of periodontitis. Citation: Journal of Veterinary Dentistry PubDate: 2024-03-12T03:27:07Z DOI: 10.1177/08987564241232862
- Intradental Displacement of a Deciduous Tooth Root in a Dog
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Authors: Charlie Tewson, Simone Kirby Abstract: Journal of Veterinary Dentistry, Ahead of Print. This case study describes the diagnosis and treatment of a deciduous left maxillary canine tooth root that had been displaced into the pulp of the developing permanent left maxillary canine tooth in a 23-month-old female neutered Cavalier King Charles Spaniel. The patient was initially presented for bilateral persistent deciduous maxillary canine teeth extraction. Seventeen months later the permanent left maxillary canine tooth was found to be non-vital and tooth development had ceased prior to apical closure. Radiographs revealed a radio-opaque dentine-like structure and straight line centrally within the pulp of the permanent tooth. The displacement of the deciduous tooth into the developing permanent tooth was confirmed. This unusual potential complication should be considered when performing deciduous teeth extraction. Citation: Journal of Veterinary Dentistry PubDate: 2024-02-20T06:35:23Z DOI: 10.1177/08987564241232856
- Evaluation of a Novel Veterinary Dental Radiography Artificial
Intelligence Software Program-
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Authors: Markay L. Nyquist, Lisa A. Fink, Glenna E. Mauldin, Curt R. Coffman Abstract: Journal of Veterinary Dentistry, Ahead of Print. There is a growing trend of artificial intelligence (AI) applications in veterinary medicine, with the potential to assist veterinarians in clinical decisions. A commercially available, AI-based software program (AISP) for detecting common radiographic dental pathologies in dogs and cats was assessed for agreement with two human evaluators. Furcation bone loss, periapical lucency, resorptive lesion, retained tooth root, attachment (alveolar bone) loss and tooth fracture were assessed. The AISP does not attempt to diagnose or provide treatment recommendations, nor has it been trained to identify other types of radiographic pathology. Inter-rater reliability for detecting pathologies was measured by absolute percent agreement and Gwet's agreement coefficient. There was good to excellent inter-rater reliability among all raters, suggesting the AISP performs similarly at detecting the specified pathologies compared to human evaluators. Sensitivity and specificity for the AISP were assessed using human evaluators as the reference standard. The results revealed a trend of low sensitivity and high specificity, suggesting the AISP may produce a high rate of false negatives and may not be a good tool for initial screening. However, the low rate of false positives produced by the AISP suggests it may be beneficial as a “second set of eyes” because if it detects the specific pathology, there is a high likelihood that the pathology is present. With an understanding of the AISP, as an aid and not a substitute for veterinarians, the technology may increase dental radiography utilization and diagnostic potential. Citation: Journal of Veterinary Dentistry PubDate: 2024-02-07T07:44:41Z DOI: 10.1177/08987564231221071
- Intraoral Radiographic Study of the Pulp Cavity of the Shortfin Mako Shark
(Isurus Oxyrinchus)-
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Authors: Gabrielle Silvestre R.C. Albuquerque, Karoline Maia, Thiago Prescinotto, Marco Antônio Ferreira da Silva Junior, Marcos Vinicius Silva, Carlos Eduardo Malavasi Bruno Abstract: Journal of Veterinary Dentistry, Ahead of Print. The shortfin mako shark (Isurus oxyrinchus) is a large pelagic predator that inhabits coastal and ocean waters. It has several teeth arranged in rows that run from the rostral to the lingual face. These teeth are in several stages of maturation, where the teeth closest to the rostral face are more mature and functional and the teeth closest to the lingual face are still in development. The tooth supply of the shark is unlimited throughout its life. The mechanism of tooth replacement follows that, when the front teeth are discarded physiologically, the posterior teeth replace it. This study us used a head and dental arch of I. oxyrinchus. Intraoral radiographs were obtained with the aim to show details of the pulp cavity. The study concluded that the pulp diameter varies according to the stage of dental maturation. Citation: Journal of Veterinary Dentistry PubDate: 2024-01-31T09:03:02Z DOI: 10.1177/08987564231226163
- Prevalence of Tooth Resorptive Lesions in 120 Feline Dental Patients in
Israel-
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Authors: Erez Cohen-Mivtach Abstract: Journal of Veterinary Dentistry, Ahead of Print. Tooth resorption (TR) is a common dental condition seen in domestic cats, with a reported prevalence of 29-37.5% in clinically healthy cats and 60.8-67% in cats presenting for dental problems. Radiological and medical records of 120 cats that underwent dental treatment at a private veterinary clinic in Israel between October 2015 and February 2023 were reviewed. Records in which full-mouth radiographs had been obtained were included in the study. Radiographs were screened for TR according to the AVDC classification. Teeth affected by TR were identified in 79/120 (66%) cats. The mean age of cats with TR and non-TR was 8.3 and 6.2 years, respectively. The median age of the TR and non-TR cat populations was 8 and 7 years, respectively. A correlation was found between the number of teeth affected per cat and the age in TR cats. Cats 10 years of age and older, had a TR prevalence of 83.3%. The teeth most commonly affected by TR (82.3%) were the mandibular fourth premolar teeth (308,408). Citation: Journal of Veterinary Dentistry PubDate: 2024-01-31T09:02:42Z DOI: 10.1177/08987564231226082
- Novel Management of Masticatory Myositis in Three Dogs with a Selective
Janus Kinase (JAK-1) Inhibitor-
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Authors: Michael C. Congiusta, Christopher Snyder, Jason W. Soukup, Neoklis Apostolopoulos Abstract: Journal of Veterinary Dentistry, Ahead of Print. Masticatory myositis (MM) is an inflammatory myopathy reported in dogs and is characterized by inflammation of the masticatory muscles (temporalis, masseter, and pterygoid muscles). Immunosuppressive therapy is the current recommended treatment for MM and may involve glucocorticoids, cyclosporine, azathioprine, mycophenolate mofetil, leflunomide, or a combination of these treatments that are slowly tapered to the lowest effective dose. However, side effects from multimodal medical therapy and complications associated with MM relapses have been reported. The purpose of this case series was to report oclacitinib as a treatment alternative to traditional medical management of MM. The intent of this alternative is to manage side effects from glucocorticoid use. Oclacitinib (1mg/kg per os q12h) was used solely for treatment of MM in three dogs. The dogs were followed up to>6 months after oclacitinib administration. An increase in oral range of motion, as determined by gape angle, was noted in all three dogs. However, a corresponding drop in antibody titers (2M fiber) did not occur. All dogs showed improvement in overall clinical management of MM, side effects from glucocorticoids, and clinical signs related to chronic prednisone use. Larger controlled trials with consistent measurements (interincisal distance, gape angle) and 2M fiber antibody titers are indicated to further assess validation of oclacitinib treatment of MM. The clinical outcome of all dogs was considered successful. Citation: Journal of Veterinary Dentistry PubDate: 2024-01-09T06:53:37Z DOI: 10.1177/08987564231219925
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