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Research Journal of Veterinary Sciences
Number of Followers: 5  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1819-1908
Published by Science Alert Homepage  [61 journals]
  • Trypanocidal Drugs Resistance and Their Utilization Practices in
           Benishangul-Gumuz Region, Ethiopia

    • Abstract: Background and Objective: Trypanocidal drug resistance is the major threat of cattle production and documentation of trypanocidal drug utilization practices is scanty in Benishangul-Gumuz Regional State. This study conducted to evaluate trypanocidal drug utilization practices and to assess trypanocidal drug resistance in naturally infected Sheko and Boran cattle. Materials and Methods: A cross-sectional survey conducted and about 86 farmers were involved. A total of 32 trypanosome-positive cattle randomly assigned to two treatment groups. Treated with a curative dosage of DIM (3.5 mg kg–1) and ISMM (0.5 mg kg–1). An abbreviated 28 days field protocol was applied. Descriptive statistics used to summarized the data. Results: About 93% of the respondents use trypanocidal drugs. Diminazene aceturate (DIM) and isometamidium chloride (ISMM) were commonly used drugs. About 31.2 and 45.7% of respondents from Assosa and Bambasi, respectively treated an animal>9 times in a year. The prevention methods practiced are avoiding flies through smoking 32/86 (37.2%), management practices to improve immunity 17/86 (19.8%) and use tsetse repellant chemicals 40/86 (46.5%). Relapse occurred in 12 animals in the first treatment and breed has a significant effect (χ2 = 4.8, p0.05) difference among drugs used. Drugs were switched in treatment failure cases. Treating first with DIM and then with ISMM was better. Conclusion: This study indicated the presence of drug resistant trypanosomes. The dependency of farmers on a limited number of drugs aggravate the issue. Strict supervision on drug usage, sanative pair treatment and, further experimental work required using molecular techniques.
      PubDate: 08 July, 2022
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