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- The potential effect of Garlium GEM HCTM as a tick control agent in cattle
Authors: FM Hagg, LJ Erasmus, WH Stoltsz
Pages: 1 - 6
Abstract: As resistance to chemical acaricides increases amongst tick populations, investigations of natural remedies that have acaricidal or tick-repellent effects have become essential in the search for alternatives for sustainable tick control. Garlium GEM HC (Garlium), a natural concentrated garlic product, was supplemented in-feed to beef cattle to determine if it could assist in reducing the number of attached ticks on cattle. Two grams of Garlium was supplemented daily to eight Bonsmara steers over 43 days. A second group of eight steers served as controls. All animals were infested with a similar number of Rhipicephalus appendiculatus adults and Rhipicephalus microplus larvae. Subsequently, the number of attached engorged ticks and the hatchability of the tick eggs were determined. Blood samples were collected from the steers for whole blood analyses. The results were analysed using a two-sample t-test procedure. Due to large standard deviations observed, most of the tick parameters were only numerically improved. Although not significant, the number of larvae produced by female R. appendiculatus ticks per host was reduced by 23%. Estimated number of R. microplus larvae produced from ticks harvested from Garlium supplemented cattle were reduced by 42.3% (p = 0.10). No adverse effect was observed on haematocrits or haemoglobin concentrations. Garlium reduced segmented neutrophil count in the treatment group, suggesting that the immune system was less challenged. Although not statistically significant, the effect of reducing the number of larvae produced per host for the two tick species by approximately 20% and 40% respectively, may be of economic benefit to commercial cattle farmers.
Keywords:
Original Research
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A case report of a cementless total hip replacement performed in a pelvic
limbamputee after a failed surgical reduction of a traumatic coxo-femoral
luxationwith a toggle rod
Authors: RC Elliott, KJ van der Wetering , A Kitshoff
Pages: 7 - 11
Abstract: Coxo-femoral luxation is the most common luxation seen in dogs after road traffic accidents. There are multiple surgical techniques to repair the luxation. These range from a capsular reconstruction to a total hip replacement. This case report describes a total hip replacement to repair a failed toggle rod repair of a coxo-femoral luxation in a Greyhound pelvic limb amputee. The dog returned to normal activity as a household pet three months post-surgery and at the last follow-up consultation at 12 months post-surgery the dog was able to maintain an acceptable activity level as an amputee with no radiographic signs of complications.
Keywords:
Case Report
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Impaired endochondral ossification in a skeletally immature dog:
implications for femoral cleft formation and suspected incomplete femoral
ossification
Authors: P Guy, C Le Roux
Pages: 12 - 15
Abstract: Historically, knowledge regarding congenital skeletal malformations in canines is poor. The Nomina Embryologica Veterinaria does not currently list any dysmorphia related to distal femoral fusion, and there is a significant absence of comprehensive descriptions of congenital defects in the veterinary literature. This paper reports on the radiographic and computed tomography (CT) characteristics of a skeletal abnormality in a seven-month-old crossbreed dog that presented for chronic right pelvic limb lameness as a result of secondary developmental patella luxation. Successful resolution of the lameness was achieved through concurrent surgical correction of the patella luxation and distal femoral cleft.
Keywords:
Case Report
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Copper (Cu) metabolism in domestic herbivores as guide to criteria for
Authors: JB Jansen van Ryssen, GF Bath
Pages: 26 - 34
Abstract: In southern Africa game farming has become an effective way of using underutilised resources and a valuable method of preserving and increasing wildlife numbers. However, little is known about the mineral requirements of wild animal species or the assessment of the mineral nutritional status of these species. To establish criteria for estimating the copper (Cu) nutritional status of wildlife, current knowledge about Cu metabolism and criteria for domestic animals has been used. Since the Cu metabolism of ruminants differs substantially from that of non-ruminants, Cu metabolism in domestic species such as cattle and sheep representing wild ruminants, and pigs and horses as non-ruminant species, has been scrutinised to propose criteria for wild bovids in southern Africa. In the adequate range of dietary Cu intakes, literature suggests that hepatic Cu concentrations in ruminants increase linearly with an increase in Cu intake, allowing a relatively reliable measure of sufficiency. In non-ruminants, hepatic Cu concentrations follow a lag phase during which hepatic Cu concentrations remain relatively constant with increasing dietary Cu intakes of more that 25 times their requirements. A consequence is that non-ruminants can tolerate much higher dietary levels of Cu compared to ruminants. It is proposed that at liver Cu concentrations of < 20 mg/kg dry matter (DM), a wild ruminant could benefit from Cu supplementation; liver Cu concentrations of between 20 and 300 mg Cu/kg DM suggest an adequate Cu intake; concentrations of 300 to 500 mg/kg DM indicate a potentially unhealthy accumulation of Cu, while liver Cu concentrations of > 500 mg/kg DM indicate that the animal probably consumed more Cu than required and might be at risk of developing Cu toxicosis.
Keywords:
Review
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Ketamine-butorphanol-medetomidine for the immobilisation of
free-livinghyenas (Crocuta crocuta)
Authors: A Roug, L Meyer, L Netshitavhadulu, M Leiberich, P Buss
Pages: 35 - 42
Abstract: Free-ranging spotted hyenas (Crocuta crocuta) are immobilised for a variety of purposes, including wildlife-human conflict mitigation, research, and veterinary treatment. Combinations of tiletamine-zolazepam (Zoletil) and medetomidine are commonly used for immobilisation of hyenas, however, recovery times are long. In this descriptive study, a total of 20 adult or subadult free-ranging hyenas were immobilised near Skukuza in the Kruger National Park using ketamine, butorphanol, and medetomidine. The goal of the study was to evaluate a suitable dose and measure cardiorespiratory effects of this combination. The quality of induction and recovery were scored using an established scoring system from 1 (excellent) to (poor). Twelve of the 20 hyenas were given an induction score of 1 (excellent), five an induction score of 2 (good), and three an induction score of 3 (fair). Of the animals with induction score = 1, the mean drug dose was 1.17 mg/kg ketamine, 0.25 mg/kg butorphanol and 0.03 mg/kg medetomidine, and the mean induction time and time to handling 6:25 minutes and 9:46 minutes respectively. The mean recovery time (from reversal to standing) was 10:16 min, which is shorter than what has been reported for tiletamine-zolazepam-based combinations in hyenas. Most hyenas were bradycardic (< 40 beats per minute) and the mean PaO2 69.5 mmHg. Three hyenas, one with induction score = 2, and two with induction scores = 3 spontaneously recovered at 33, 44 and 56 minutes post approach respectively. Regardless of induction time, all hyenas reached a level of surgical anaesthesia while immobilised. Overall, ketamine-butorphanol-medetomidine (KBM) was effective in immobilising hyenas but induction times varied, and animals were bradycardic during immobilisation.
Keywords:
Original Research
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Comparison of exposure of the radius afforded by the craniomedial and
craniolateral open surgical approaches in dog cadavers
Authors: SK Crowdis, DD Lewis
Pages: 43 - 48
Abstract: Management of antebrachial fractures in dogs typically involves open reduction and bone plate stabilisation of the radius performed using either a craniomedial approach (CMA) or craniolateral approach (CLA). The aim of this cadaveric study was to compare radial exposure afforded via the craniomedial and craniolateral approaches, without and with releasing the abductor digiti I longus (ADIL) muscle. The CMA and CLA were performed on alternate paired cadaver forelimbs with the subsequent release (CMA) or elevation (CLA) of the ADIL muscle (n = 12). The percent area of exposure was calculated in defined longitudinal radial segments (LRSs) and hemi-circumferential radial segments (HRSs) using digitally uploaded images. A non-parametric rank sum test was used for statistical analysis (p < 0.05). While both the CMA and CLA provided sufficient exposure for radial cranial plate placement in the mid-to-distal diaphyseal region (50–80% LRSs), the CMA afforded greater exposure to the distal metaphysis (80–90% LRS). The CLA was advantageous in exposing the proximal diaphysis (20–50% LRSs) and distal epiphysis (90–100% LRS). Exposure of the distal diaphyseal, metaphyseal, and epiphyseal regions (80–100% LRSs) was impeded by the ADIL muscle. A tenotomy of the tendon of insertion of the ADIL muscle increased exposure afforded by the CMA in the distal metaphyseal and epiphyseal regions. The exposure afforded by the CLA in the distal diaphyseal and metaphyseal regions was significantly improved by elevating the origin of the ADIL muscle. The results of this study provide useful clinical information when surgeons are deciding which approach to use for cranial radial plating.
Keywords:
Original Research
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A novel loop-mediated isothermal amplification (LAMP) assay to diagnose
feline panleukopenia
Authors: RA Bakde, RL Rathish, J Lijo, PM Deepa, K Vijayakumar
Pages: 49 - 54
Abstract: Protoparvovirus carnivoran1, known commonly as feline panleukopenia virus (FPV) is a highly contagious and environmentally stable parvovirus of domestic as well as wild felids. A rapid and robust diagnostic tool will aid in implementing prompt treatment and control measures. A loop-mediated isothermal amplification (LAMP) as a point-of-care diagnostic tool for diagnosing feline panleukopenia was standardised using faecal samples of cats. The assay will reduce the cost and time required to diagnose feline panleukopenia. A set of two outer primers (F3 and B3) and two inner primers (FIP and BIP) were designed to target the viral polypeptide (VP2) gene of FPV. Optimisation of the LAMP reaction was done at 60 °C for one hour after an initial denaturation at 95 °C for five minutes. Visualisation of the result based on the addition of SYBR Green 1 dye offered an easy and reliable diagnosis. The detection limit of the standardised LAMP assay was as low as 1.25 ng/μl of the target DNA. Species specificity of the LAMP primers revealed no amplification of the non-target DNA of any other species except that of the canine parvovirus DNA template. DNA extracted from 100 PCR-positive and 20 PCR-negative faecal samples were subjected to the standardised assay and compared with PCR. Analysis of the results revealed that the LAMP assay was 100% sensitive and 90% specific compared to PCR. The LAMP assay could be a reliable tool for the point-of-care diagnosis of feline panleukopenia in limited resource settings.
Keywords:
Original Research
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Parasites burden in peri-urban free-roaming pigs in Gert Sibande District
Municipality, Mpumalanga Province, South Africa
Authors: P Munzhelele, NPS Sibeko, JW Oguttu, CA Mbajiorgu, FO Fasina
Pages: 55 - 66
Abstract: Background: Parasite infections, unlike regulated animal diseases, do not often receive attention. In fact, parasites are major sources of financial losses in pig enterprises, particularly in subsistence and small-scale pig production systems. Objective: To identify and quantify the prevalence of ecto- and endo-parasites among peri-urban free-roaming pigs (FRP) in Gert Sibande District Municipality (GSDM), Mpumalanga. Method: Pig owners were identified using the snowball sampling method since no sampling frame for FRP farmers exists. Stratified sampling was used to select pigs for sampling for ecto- and endo-parasites. A form was used to record the observations. Pairwise correlation analysis was performed using Stata 15.0. The SPSS V28.0 statistical package was used to perform the chi-square test (X2) to assess the distribution of parasites in different age groups. The prevalence of parasites was assessed in different age groups of pigs using multi-response crosstabs. Multivariate analysis of variance (MANOVA) was used to estimate the marginal mean of parasites according to municipality. Statistical significance was assessed at α ≤ 0.05. Results: Over 90% (91.2%) of the pigs examined were infested with at least one parasite, including Haematopinus suis, Sarcoptes scabiei, Ascaris suum, Fasciola hepatica, Trichuris suis, Strongylids, Coccidia spp, Moniezia expansa, and Siphonaptera spp. The correlation between Ascaris suum and body condition was weak but statistically significant (r = 0.24; p < 0.05). Conclusion: Policy makers, animal researchers and veterinary services must focus on developing policies, risk communication and community engagement materials, which target pig farmers in peri-urban areas such as Gert Sibande District Municipality, Mpumalanga Province.
Keywords:
Original Research
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Effect of asiatic acid supplementation in tris-extender on post-thaw
functional competence, antioxidant enzyme activity and in vivo fertility
of bull sperm
Authors: M Jameel, IS Sheikh, N Kakar, MR Yousuf, A Riaz, W Shehzad , D Khan, M Iqbal, AM Tareen
Pages: 67 - 73
Abstract: Reactive oxygen species at supra-physiological levels trigger oxidative stress during cryopreservation, which can be neutralised by incorporating suitable antioxidants into the semen extender medium. This study was intended to explore the effect of asiatic acid (AA) as an antioxidant in semen extender on frozen-thawed sperm quality and in vivo fertility of bull sperm. Semen was collected from Holstein Friesian bulls for 10 consecutive weeks (total ejaculates = 60). Semen was cryopreserved with a Tris citric acid egg yolk-based extender supplemented with 0 (control), 20, 40, 60, and 100 μM AA. The supplementation of the extender with 40 and 60 μM AA improved (p < 0.05) post-thaw motility kinematics, plasma membrane integrity, acrosome integrity, sperm viability, and DNA integrity of bull sperm. Mitochondrial membrane potential was high (p < 0.05) with 60 μM of AA concentration in extender media. The catalase activity in seminal plasma was maintained (p < 0.05) when semen was added with 20, 40, and 60 μM of AA. The in vivo fertility was found to be significantly high with the semen extended with 60 μM AA. Conclusively, this study showed that AA supplementation in semen extender significantly improved sperm motility kinematics and cell integrity, conserved antioxidant enzyme activity, and improved in vivo fertility.
Keywords:
Original Research
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Immobilisation protocols for wild giraffe (Giraffa spp.) – a review
Authors: S Ferguson, RJ Harvey, S Fennessy, J Fennessy
Pages: 74 - 79
Abstract: Background: Immobilisation of wild giraffe (Giraffa spp.) is challenging due to their unique anatomy and physiology. Field immobilisations are required for numerous conservation, tourism, and veterinary purposes. Wild giraffe immobilisation techniques have evolved considerably from physical to chemical with ultrapotent drugs. Objective: To provide a detailed overview of historic and present protocols used for immobilising giraffe in the wild as a valuable resource tool for future research into best practices. Methods: A systematic review was undertaken of the published literature on wild giraffe capture and immobilisation techniques with no restrictions on publication date. Results: The review detailed the evolution of capture techniques used for wild giraffe. The trend has moved from purely physical capture in the 1950s to the use of high dose ultrapotent opioids or a combination of opioids and alpha-2 agonists and/or tranquilisers. With a better understanding of giraffe physiology and wild giraffe capture, mortality rates have decreased significantly from ~ 35% to < 1%. Conclusion: The advent of ultrapotent opioids has caused a paradigm shift in wildlife immobilisation, especially for wild giraffe. While the use of these drugs, as sole immobilisation agents or in combination with alpha-2 agonists or tranquilisers, has greatly reduced mortality rates associated with wild giraffe immobilisations, there is a startling lack of physiological data evaluating the impact of these drugs on giraffe during and after immobilisation. Future research should focus on measuring physiological variables to determine the impact and best practice of these protocols on wild giraffe immobilisation.
Keywords:
Review
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Comparison of the immobilisation and cardiorespiratory effects of
thiafentanil-azaperone versus thiafentanil-medetomidine-azaperone
inAfrican buffalo (Syncerus caffer)
Authors: VE Faber, REJ Burroughs, LCR Meyer, HJ Hansen, D Gerber, KN Koeppel
Pages: 80 - 87
Abstract: African buffalo (Syncerus caffer) are frequently immobilised for veterinary interventions, disease screening and translocations. Concerns over user and animal safety, costs, and irregularities in opioid supply, have led to the development of alternative immobilisation protocols. This study compared immobilisation of 12 boma-habituated African buffalo with thiafentanil-azaperone (TA) vs. thiafentanil-medetomidine-azaperone (TMA) in a randomised crossover study. Each buffalo received a combination of thiafentanil (6–7 mg) + azaperone (40 mg) and thiafentanil (1 mg) + medetomidine (3–4 mg) + azaperone (40 mg) with a three-week washout period between immobilisations. Induction and recovery times were recorded, quality of induction and immobilisation were scored subjectively, and physiological variables were monitored. The TMA combination induced immobilisation with 1/7th of the TA thiafentanil dose and at a quarter of the cost. Induction times for the TA combination were significantly faster at 5.7 ± 1.6 min and more reliable compared to the TMA combination at 10.95 ± 3.9 min. Both combinations resulted in severe hypoxaemia, however hypoxaemia was overall more pronounced in the TMA (PaO2 44 ± 14 mmHg) combination compared to the TA (PaO2 51 ± 13,33 mmHg) combination and resulted mainly from decreased pulmonary oxygen exchange rather than hypoventilation; PaCO2 values were mostly within the normal expected physiological range. Supplementary oxygen and close monitoring of blood oxygenation is considered essential with either combination. Although the reduction in costs could be beneficial for the wildlife industry, longer induction times, and risks from severe hypoxaemia need to be taken into consideration when the TMA combination is used.
Keywords:
Original Research
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Low-cost uncrewed aerial vehicles (UAVs) as a novel tool for welfare
assessments on open pen commercial crocodile farms
Authors: A Myburgh, DM Viljoen, JG Myburgh, CT Downs, EC Webb, SM Woodborne
Pages: 88 - 94
Abstract: Background: The welfare of crocodiles on commercial farms in southern Africa requires precise assessment, focusing on stocking densities and pen conditions. However, disputes between animal welfare groups and farm owners persist due to inadequate methodologies for quantifying these factors. Objectives: This study aimed to address these disputes and enhance crocodile welfare assessment by introducing a novel technique using a low-cost consumer uncrewed aerial vehicle (UAV) and open-source photogrammetry software. The objective was to quantify key welfare parameters accurately and efficiently. Method: The study involved applying the UAV-based technique to two large Nile crocodile (Crocodylus niloticus) farms in South Africa. The approach enabled the mapping and surveying of crocodile pens, facilitating the determination of stocking densities, biomass indicators, and other pen-related attributes. Comparisons were made between UAV-derived crocodile counts and farmer estimates. Results: The UAV-based crocodile counts significantly differed from the estimates provided by farmers, underscoring the need for a more precise assessment method. The technique’s cost-effectiveness was evident, with implementation expenses totalling less than R10 000, a fraction of the cost associated with commercial UAV surveys. Conclusions: The introduced UAV-based technique offers a valuable solution to the ongoing debates regarding crocodile welfare on commercial farms. By quantifying key parameters accurately and economically, it empowers farmers and animal welfare groups to make informed decisions. The method’s ease of adoption, demonstrated through its use by some Southern African crocodile farmers, signifies its potential for widespread application, ultimately contributing to improved crocodile welfare.
Keywords:
Original Research
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Helminth parasites of impalas, Aepyceros melampus, in eastern southern
Africa, collected during 1973 to 2007
Authors: IG Horak, K Junker, LEO Braack, GJ Gallivan
Pages: 95 - 108
Abstract: This paper summarises published and unpublished data on helminths collected systematically from 424 impalas at 11 localities in eastern southern Africa, from St. Lucia in KwaZulu-Natal (KZN) to the Tuli Block in north-eastern Botswana. It includes data on collections in the Kruger National Park (KNP) in the drought of 1982, and in 1992/93 following the 1991/92 drought. Thirty-three species of nematodes, plus six taxa identified only to the generic level, three taxa of trematodes, and three species of cestodes were collected. Helminth species richness was highest in the southern KNP and lowest in the Tuli Block. The prevalence and intensity of infection of several helminths also declined from KZN and the southern KNP to the drier areas in the north and west. With the exception of St. Lucia and Nylsvley, > 80% of the helminths collected at each locality were collected in the southern KNP. St. Lucia was the most dissimilar locality; of the 20 helminths collected, five were unique. Ten of 33 species of nematodes, the paramphistomines (Trematoda) and the cestode Stilesia hepatica were collected at seven or more localities. Six of the most common nematodes, Cooperia hungi, Cooperioides hamiltoni, Impalaia tuberculata, Longistrongylus sabie, Strongyloides papillosus and Trichostrongylus deflexus are primarily parasites of impalas in the southern KNP, whereas many of the helminths collected at only one or two localities are parasites of other hosts. Nematode burdens were increased in the drought affected impalas in 1982, but helminth burdens decreased in 1992/93 following a dry cycle.
Keywords:
Original Research
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Retrospective case-control non-inferiority analysis of ultrasound-guided
erector spinae plane block in dogs undergoing mini-hemilaminectomy for
intervertebral disc disease
Authors: DN Alza Salvatierra, L Motta, JI Redondo, M du Toit, E Pompermaier, M Martinez
Pages: 109 - 120
Abstract: Background: Veterinary medicine has seen significant advancements in locoregional anaesthesia and pain management, including the emergence of the erector spinae plane (ESP) block. However, limited clinical evidence exists on its efficacy and safety. Objectives: This study compares ultrasound-guided ESP block (ESP group) with an intraoperative intravenous ketamine infusion analgesic protocol (CRI group) in dogs undergoing thoracolumbar mini-hemilaminectomy, focusing on intraoperative opioid consumption, cardiovascular response to surgical stimulation (CR), postoperative pain scores (PS), and postoperative opioid consumption. Methods: Retrospective, case-control, non-inferiority study conducted in a single centre. Data collected included demographics, bupivacaine dose, ESP block operator, intraoperative recorded variables (haemodynamic variables, CR, complications, rescue analgesia), pre- and postoperative analgesia, 24-hour PS and opioid administration, first food intake post-extubation and postoperative complications. Univariate and multiple regression analyses were applied. Results: One-hundred dogs were included, 75 in the ESP group and 25 in the CRI group. Univariate analysis revealed no significant differences between treatment groups in terms of CR, PS, postoperative rescue analgesia, intraoperative and postoperative opioid consumption, or time to first meal intake. However, the multivariate regression analysis indicated that dogs receiving ketamine infusion had higher CR suspected to be nociception-related (p = 0.036), and higher postoperative opioid consumption (p = 0.013). Conclusion: Our study suggests that ultrasound-guided ESP block is as effective as intraoperative ketamine infusion providing perioperative analgesia in dogs undergoing thoracolumbar mini-hemilaminectomy for intervertebral disc disease. ESP group showed significantly lower CR suspected to be nociception-related intraoperatively and lower postoperative opioid consumption within the initial 24 hours.
Keywords:
Original Research
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Detection and quantification of antibiotic residues in goat milk in
Mahikeng Local Municipality
Authors: KL Ndlovu, M Mwanza, N Nleya, L Ngoma
Pages: 121 - 130
Abstract: Goat milk could be used to reduce malnutrition since it is highly nutritious, and many people in rural communities in South Africa rear small ruminants for survival. However, the risk of food contamination by antibiotic residues is one of the significant problem facing public health, and is a result of the irresponsible use of veterinary drugs. One hundred goat farmers were interviewed using a questionnaire, and raw milk samples from 266 goats were collected and analysed for the presence of antibiotic residues. Screening for amoxicillin, tetracycline, sulfamethazine, erythromycin, and streptomycin residues was done using the enzyme-linked immunosorbent assay (ELISA) while high-performance liquid chromatography (HPLC) was carried out for confirmation. The questionnaire shows that all (100%) of the participants acknowledged the use of antibiotics on their goats and 99% of them were aware of the possibility of antibiotic residues in milk. ELISA results for residues of erythromycin, sulfamethazine and amoxicillin exceeded the Codex Alimentarius maximum residue levels (MRLs) in 94.7%, 82.3%, and 35.3% of analysed samples, respectively. Tetracycline was present in all (100%) analysed milk samples, and streptomycin was detected in 18.7% of samples; however, these results were below the recommended MRLs. The HPLC method confirmed the presence of streptomycin and tetracycline residues in 90% and 40% of the samples analysed. However, the concentrations were below the accepted MRL standards. Approximately 76.6% of samples exceeded the established MRL for sulfamethazine and 10% for erythromycin. Amoxicillin was not detected by the HPLC method. The results obtained in this study indicate a high level of contamination of goat milk with antibiotic residues, which may harm the health of the consumers.
Keywords:
Original Research
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The time course of lactate and endocrine changes in dogs suffering from
dog bite wounds
Authors: E Damhuis, PN Thompson, JP Schoeman
Pages: 131 - 136
Abstract: Background: The stress response after acute trauma in humans and animals has been well-recognised in the literature. However, data on temporal changes in endocrine parameters after acute trauma in previously healthy dogs are scant. Objective: To longitudinally track endocrine variables and lactate concentrations in dogs with canine bite wounds. Method: Prospective study involving 20 dogs hospitalised after being bitten by another dog. Serum cortisol, thyroxine (total T4), thyrotropin (TSH), and lactate concentrations were measured on admission and every 8 hours after the recorded bite incident, for a 72-hour period. Results: Median cortisol concentration was markedly elevated on admission (314.6 nmol/L; IQR 229.3–369.6) but returned to within the reference interval by 16 hours post-bite (99.5 nmol/L; IQR 48.7–225.4) and reached a nadir at 48 hours post-bite (38.5 nmol/L; IQR 32.1–115.9). Median total T4 concentration was within the reference interval on admission (20.6 nmol/L; IQR 12.7–27.9) but decreased below the reference interval by 8 hours (11.0 nmol/L; IQR 5.0–14.1) and reached a nadir 16 hours post-bite (7.0 nmol/L; IQR 2.9–19.7), before gradually increasing after 64 hours to reach the reference range by 72 hours. The median TSH concentrations remained within the reference interval throughout the study period. Median lactate concentration was mildly elevated on admission (3.0 mmol/L; IQR 2.0–3.9). Conclusion: This study produced novel data on the temporal relationships of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary- thyroidal axes alterations after an acute traumatic insult in dogs.
Keywords:
Original Research
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