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  Subjects -> NUTRITION AND DIETETICS (Total: 201 journals)
Showing 1 - 64 of 64 Journals sorted by number of followers
American Journal of Clinical Nutrition     Hybrid Journal   (Followers: 176)
British Journal Of Nutrition     Hybrid Journal   (Followers: 96)
Clinical Nutrition     Hybrid Journal   (Followers: 94)
International Journal of Obesity     Hybrid Journal   (Followers: 93)
International Journal of Sport Nutrition & Exercise Metabolism     Hybrid Journal   (Followers: 88)
European Journal of Clinical Nutrition     Hybrid Journal   (Followers: 75)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 62)
Journal of the Academy of Nutrition and Dietetics     Full-text available via subscription   (Followers: 61)
Food Science & Nutrition     Open Access   (Followers: 59)
Obesity     Hybrid Journal   (Followers: 58)
Advances in Nutrition     Hybrid Journal   (Followers: 55)
Annals of Nutrition and Metabolism     Full-text available via subscription   (Followers: 52)
Journal of Pediatric Gastroenterology and Nutrition (JPGN)     Hybrid Journal   (Followers: 52)
Journal of Human Nutrition and Dietetics     Hybrid Journal   (Followers: 52)
Diabetes, Metabolic Syndrome and Obesity     Open Access   (Followers: 48)
American Journal of Food and Nutrition     Open Access   (Followers: 48)
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 45)
Journal of Nutrition     Hybrid Journal   (Followers: 42)
Annual Review of Nutrition     Full-text available via subscription   (Followers: 40)
Nutrition Reviews     Hybrid Journal   (Followers: 38)
European Journal of Nutrition     Hybrid Journal   (Followers: 36)
Food & Nutrition Research     Open Access   (Followers: 35)
Journal of Parenteral and Enteral Nutrition     Hybrid Journal   (Followers: 35)
International Journal of Behavioral Nutrition and Physical Activity     Open Access   (Followers: 31)
Nutrition & Dietetics     Hybrid Journal   (Followers: 31)
Public Health Nutrition     Hybrid Journal   (Followers: 30)
Journal of Nutrition, Health and Aging     Hybrid Journal   (Followers: 30)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 28)
Current Opinion in Clinical Nutrition & Metabolic Care     Hybrid Journal   (Followers: 26)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 25)
Appetite     Hybrid Journal   (Followers: 25)
Obesity Reviews     Hybrid Journal   (Followers: 25)
Current Nutrition & Food Science     Hybrid Journal   (Followers: 25)
Journal of Obesity     Open Access   (Followers: 24)
Childhood Obesity     Hybrid Journal   (Followers: 24)
International Journal of Nutrition and Metabolism     Open Access   (Followers: 23)
International Journal of Eating Disorders     Hybrid Journal   (Followers: 23)
Nutrition Research     Hybrid Journal   (Followers: 23)
Clinical Nutrition ESPEN     Hybrid Journal   (Followers: 23)
Advances in Eating Disorders : Theory, Research and Practice     Hybrid Journal   (Followers: 22)
Nutrition     Hybrid Journal   (Followers: 22)
Comparative Exercise Physiology     Hybrid Journal   (Followers: 21)
Nutrition & Diabetes     Open Access   (Followers: 20)
International Journal of Food Safety, Nutrition and Public Health     Hybrid Journal   (Followers: 20)
Journal of Nutrition Education and Behavior     Hybrid Journal   (Followers: 19)
Topics in Clinical Nutrition     Hybrid Journal   (Followers: 19)
Clinical Obesity     Hybrid Journal   (Followers: 18)
American Journal of Botany     Full-text available via subscription   (Followers: 18)
Canadian Journal of Dietetic Practice and Research     Full-text available via subscription   (Followers: 17)
Nutrition & Metabolism     Open Access   (Followers: 17)
African Journal of Food, Agriculture, Nutrition and Development     Open Access   (Followers: 17)
Journal of Nutrition and Metabolism     Open Access   (Followers: 16)
Journal of Advanced Nutrition and Human Metabolism     Open Access   (Followers: 16)
Nutrition and Dietary Supplements     Open Access   (Followers: 15)
Journal of Eating Disorders     Open Access   (Followers: 15)
Journal of Nutrition in Gerontology and Geriatrics     Hybrid Journal   (Followers: 15)
Maternal & Child Nutrition     Hybrid Journal   (Followers: 14)
Nutrition Today     Hybrid Journal   (Followers: 14)
Nutrition Research Reviews     Hybrid Journal   (Followers: 13)
Nutrition, Metabolism and Cardiovascular Diseases     Hybrid Journal   (Followers: 13)
Nutrition and Cancer     Hybrid Journal   (Followers: 13)
Food, Culture and Society: An International Journal of Multidisciplinary Research     Full-text available via subscription   (Followers: 13)
BMC Nutrition     Open Access   (Followers: 13)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Nutrients     Open Access   (Followers: 13)
Journal of Health, Population and Nutrition     Open Access   (Followers: 13)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Nutrition Journal     Open Access   (Followers: 12)
BMJ Nutrition, Prevention & Health     Open Access   (Followers: 12)
Asian Journal of Clinical Nutrition     Open Access   (Followers: 12)
Food and Foodways: Explorations in the History and Culture of     Hybrid Journal   (Followers: 12)
Advances in Digestive Medicine     Open Access   (Followers: 12)
International Journal of Food Sciences and Nutrition     Hybrid Journal   (Followers: 11)
Nutrition Bulletin     Hybrid Journal   (Followers: 11)
Frontiers in Nutrition     Open Access   (Followers: 11)
Ecology of Food and Nutrition     Hybrid Journal   (Followers: 10)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
International Journal for Vitamin and Nutrition Research     Hybrid Journal   (Followers: 10)
Journal of Food and Nutrition Research     Open Access   (Followers: 10)
Journal of Dietary Supplements     Hybrid Journal   (Followers: 10)
American Journal of Food Technology     Open Access   (Followers: 9)
Pediatric Obesity     Hybrid Journal   (Followers: 9)
Nutritional Neuroscience : An International Journal on Nutrition, Diet and Nervous System     Hybrid Journal   (Followers: 9)
Obesity Facts     Open Access   (Followers: 9)
Nutrition & Food Science     Hybrid Journal   (Followers: 9)
Proceedings of the Nutrition Society     Hybrid Journal   (Followers: 8)
Current Nutrition Reports     Hybrid Journal   (Followers: 8)
Journal of Nutritional Biochemistry     Hybrid Journal   (Followers: 8)
Amino Acids     Hybrid Journal   (Followers: 8)
Nutrition and Health     Hybrid Journal   (Followers: 8)
Journal of Hunger & Environmental Nutrition     Hybrid Journal   (Followers: 7)
Journal of the American College of Nutrition     Hybrid Journal   (Followers: 7)
Current Developments in Nutrition     Open Access   (Followers: 6)
Journal of Food Chemistry and Nutrition     Open Access   (Followers: 6)
International Journal of Food Science and Nutrition Engineering     Open Access   (Followers: 6)
Molecular Nutrition & Food Research     Hybrid Journal   (Followers: 6)
International Journal of Child Health and Nutrition     Hybrid Journal   (Followers: 6)
Current Research in Nutrition and Food Science     Open Access   (Followers: 6)
Food and Nutrition Bulletin     Hybrid Journal   (Followers: 6)
Nutrition - Science en évolution     Full-text available via subscription   (Followers: 5)
Nutrition Bytes     Open Access   (Followers: 5)
Food Digestion     Hybrid Journal   (Followers: 5)
South African Journal of Clinical Nutrition     Open Access   (Followers: 5)
Bangladesh Journal of Nutrition     Open Access   (Followers: 5)
Plant Foods for Human Nutrition     Hybrid Journal   (Followers: 5)
Genes & Nutrition     Open Access   (Followers: 5)
Journal of Pharmacy and Nutrition Sciences     Open Access   (Followers: 5)
Universal Journal of Food and Nutrition Science     Open Access   (Followers: 4)
Nutrition and Metabolic Insights     Open Access   (Followers: 4)
Metabolism and Nutrition in Oncology     Open Access   (Followers: 4)
Journal of Medical Nutrition and Nutraceuticals     Open Access   (Followers: 4)
International Journal of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
World Food Policy     Hybrid Journal   (Followers: 3)
Journal of Agriculture, Food Systems, and Community Development     Open Access   (Followers: 3)
Frontiers in Sustainable Food Systems     Open Access   (Followers: 3)
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 3)
Nutrición Hospitalaria     Open Access   (Followers: 3)
PharmaNutrition     Hybrid Journal   (Followers: 3)
Revista Española de Nutrición Humana y Dietética     Open Access   (Followers: 3)
Ernährung & Medizin     Hybrid Journal   (Followers: 3)
Perspectivas en Nutrición Humana     Open Access   (Followers: 2)
Pakistan Journal of Nutrition     Open Access   (Followers: 2)
Oil Crop Science     Open Access   (Followers: 2)
Acta Portuguesa de Nutrição     Open Access   (Followers: 2)
Open Nutrition Journal     Open Access   (Followers: 2)
Journal of Spices and Aromatic Crops     Open Access   (Followers: 2)
Food Quality and Safety     Open Access   (Followers: 2)
Journal of Nutritional & Environmental Medicine     Full-text available via subscription   (Followers: 2)
Progress in Nutrition     Open Access   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Revista Chilena de Nutricion     Open Access   (Followers: 2)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 2)
International Journal of Gastroenterology, Hepatology, Transplant and Nutrition     Open Access   (Followers: 2)
Bioactive Carbohydrates and Dietary Fibre     Hybrid Journal   (Followers: 2)
Nigerian Food Journal     Full-text available via subscription   (Followers: 2)
Lifestyle Genomics     Open Access   (Followers: 2)
Journal of Nutritional Science     Open Access   (Followers: 2)
Food and Health     Open Access   (Followers: 1)
The Australian Coeliac     Full-text available via subscription   (Followers: 1)
Endocrinología, Diabetes y Nutrición     Full-text available via subscription   (Followers: 1)
Amerta Nutrition     Open Access   (Followers: 1)
Archive of Food and Nutritional Science     Open Access   (Followers: 1)
Open Obesity Journal     Open Access   (Followers: 1)
Food and Environmental Virology     Hybrid Journal   (Followers: 1)
Case Reports in Clinical Nutrition     Open Access   (Followers: 1)
European Journal of Nutrition & Food Safety     Open Access   (Followers: 1)
Journal of Food Science and Nutrition Therapy     Open Access   (Followers: 1)
Human Nutrition & Metabolism     Open Access   (Followers: 1)
Food Frontiers     Open Access   (Followers: 1)
Journal of Food & Nutritional Disorders     Hybrid Journal   (Followers: 1)
Plant Production Science     Open Access   (Followers: 1)
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Jurnal Penelitian Gizi dan Makanan     Open Access   (Followers: 1)
Journal of Ethnic Foods     Open Access   (Followers: 1)
Clinical Nutrition Experimental     Open Access   (Followers: 1)
RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento     Open Access   (Followers: 1)
Cahiers de Nutrition et de Diététique     Full-text available via subscription   (Followers: 1)
Indian Journal of Nutrition and Dietetics     Hybrid Journal   (Followers: 1)
Canadian Food Studies / La Revue canadienne des études sur l'alimentation     Open Access   (Followers: 1)
Revista Mexicana de Trastornos Alimentarios     Open Access   (Followers: 1)
RBNE - Revista Brasileira de Nutrição Esportiva     Open Access   (Followers: 1)
Jurnal Gizi dan Dietetik Indonesia : Indonesian Journal of Nutrition and Dietetics     Open Access   (Followers: 1)
Clinical Nutrition Open Science     Open Access  
Food Hydrocolloids for Health     Open Access  
npj Science of Food     Open Access  
Functional Foods in Health and Disease     Open Access  
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Arab Journal of Nutrition and Exercise     Open Access  
Nutrire     Hybrid Journal  
UNICIÊNCIAS     Open Access  
Lifestyle Journal     Open Access  
Archivos Latinoamericanos de Nutrición     Open Access  
Revista Salud Pública y Nutrición     Open Access  
Open Food Science Journal     Open Access  
Segurança Alimentar e Nutricional     Open Access  
Indonesian Food and Nutrition Progress     Open Access  
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
La Ciencia al Servicio de la Salud y Nutrición     Open Access  
Jurnal Riset Kesehatan     Open Access  
Jurnal Gizi Indonesia / The Indonesian Journal of Nutrition     Open Access  
Hacettepe University Faculty of Health Sciences Journal     Open Access  
Gazi Sağlık Bilimleri Dergisi     Open Access  
Media Gizi Indonesia     Open Access  
Jurnal Gizi Klinik Indonesia     Open Access  
NFS Journal     Open Access  
Journal of Nutrition & Intermediary Metabolism     Open Access  
Food and Waterborne Parasitology     Open Access  
Journal of Nutritional Ecology and Food Research     Full-text available via subscription  
Journal of Nutritional Disorders & Therapy     Open Access  
DEMETRA : Alimentação, Nutrição & Saúde     Open Access  
Nigerian Journal of Nutritional Sciences     Full-text available via subscription  
African Journal of Biomedical Research     Open Access  
Journal of the Australasian College of Nutritional and Environmental Medicine     Full-text available via subscription  
Médecine & Nutrition     Full-text available via subscription  
Journal of Sensory Studies     Hybrid Journal  
Journal of Muscle Foods     Hybrid Journal  

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Similar Journals
Journal Cover
Journal of Pediatric Gastroenterology and Nutrition (JPGN)
Journal Prestige (SJR): 1.376
Citation Impact (citeScore): 2
Number of Followers: 52  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0277-2116 - ISSN (Online) 1536-4801
Published by LWW Wolters Kluwer Homepage  [330 journals]
  • Journal of Pediatric Gastroenterology and Nutrition 2022 Reviewer
           Acknowledgement

    • Free pre-print version: Loading...

      Abstract: No abstract available
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Health Care Disparities in Gastroenterology: The Pediatric
           Gastroenterology Perspective

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      Authors: Cohran; Valeria C.; Gold, Benjamin D.; Spencer, Dennis J.; Cole, Conrad R.
      Abstract: imageNo abstract available
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • The rs12532734 Polymorphism Near the Solute Carrier 26A3 Gene Locus Is
           Associated With Gallstone Disease in Children

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      Authors: Krawczyk; Marcin; Niewiadomska, Olga; Jankowska, Irena; Jankowski, Krzysztof; Świderska, Jolanta; Lebensztejn, Dariusz; Więcek, Sabina; Gozdowska, Jolanta; Kułaga, Zbigniew; Weber, Susanne N.; Lammert, Frank; Socha, Piotr
      Abstract: imageGallstones are increasingly frequent in children. In this candidate gene study, we genotyped 5 gene variants (ANO1, SPTLC3, TMEM147, TNRC6B, rs12532734) from a recent gallstone genome-wide association study (GWAS) in a cohort of 214 children with gallstones and 172 gallstone-free adult controls. In total, 138 genotyped children presented with symptomatic gallstone disease, 47 underwent cholecystectomy, and 126 received ursodeoxycholic acid (UDCA) as therapy for stones. Among 5 tested variants, the rs12532734 polymorphism modulated the gallstone risk in the studied cohort. Its genotype distribution significantly (P = 0.025) departed from the Hardy-Weinberg equilibrium among cases, and the common allele was associated with increased odds of developing gallstones at young age (OR = 1.69, P = 0.014). SLC26A3 is the nearest gene to rs12532734 and is involved in the transepithelial bicarbonate and chloride transport. The association of rs12532734 with pediatric gallstones is a novel finding warranting further investigations also with regard to biliary bicarbonate flux and bile composition.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Intra- and Inter-observer Agreement of High Resolution Antroduodenal
           Manometry in Pediatric Patients Among Single Center Experts

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      Authors: Valitutti; Francesco; Lindley, Keith; Saliakellis, Efstratios; Chanpong, Atchariya; Pesce, Marcella; Rybak, Anna; Thapar, Nikhil; Borrelli, Osvaldo
      Abstract: imageObjectives: Studies in adults have suggested that high-resolution technology increases the diagnostic yield of antroduodenal manometry (ADM). However, there is no study comparing high-resolution with low-resolution ADM recordings as well as comparing the 2 types of high-resolution display [conventional line plot (CLP) and pressure topographic plots (PTP)]. We hypothesized that high-resolution ADM is a superior diagnostic modality with higher inter-observer and intra-observer agreement compared with low-resolution recordings.Methods: Twenty-four anonymized ADM studies were blindly analyzed by 3 experienced pediatric neurogastroenterologists. All studies had been performed using a low-compliance water-perfused system with a 20-channels catheter. Data were displayed as CLP, as both high-resolution and low-resolution, and PTP in different sessions with at least 6-week interval. Accuracy was evaluated using previous established diagnosis and specific pre-prandial and post-prandial manometric patterns. Inter-observer and intra-observer agreements were calculated.Results: Analysis with high-resolution CLP revealed a substantial inter-observer agreement among the 3 observers regarding the diagnosis (Krippendorff’s alpha: 0.832; average pairwise percentage agreement: 88.9%). Conversely, PTP and low-resolution CLP showed poor agreement for diagnoses (Krippendorff’s alpha: 0.600; average pairwise percentage agreement: 75.3%; Krippendorff’s alpha: 0.390; average pairwise percentage agreement: 60.2%, respectively). For the intra-observer agreement, Krippendorff’s alpha ranges were 0.891–1 for CLP and 0.19393–0.34621 for PTP.Conclusions: Our study demonstrated higher diagnostic accuracy for high-resolution ADM compared to the low-resolution recordings. However, although it is well established for other motility investigations, PTP is not yet reliable in assessing foregut motor patterns. Advanced and more sophisticated software are clearly required for analyzing PTP display.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Relationship of Functional Constipation and Growth Status: A Systematic
           Review and Meta-Analysis

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      Authors: Lazarus; Glen; Junaidi, Michelle Clarissa; Oswari, Hanifah
      Abstract: imageObjectives: Functional constipation (FC) and malnutrition are 2 of the most common diseases affecting children worldwide with long-term consequences. We hereby performed a systematic review and meta-analysis to analyze the relationship between these 2 entities.Methods: We searched PubMed, American Academics of Pediatrics (AAP), Cochrane, ClinicalTrials.gov (from inception to December 11, 2021) using “constipation,” “growth,” and “children” as the keywords. Newcastle-Ottawa Scale was used as the risk of bias assessment tool. Meta-analysis using the random-effects model was done.Results: Eighteen studies involving 33,410 children were chosen in this study. Meta-analysis of all the studies showed statistically significant relationship between FC with both overweight/obesity [odds ratio (OR) = 1.75; 95% confidence interval (CI) = 1.11-2.76; P = 0.02], in Asian countries subgroup, and undernutrition (OR = 2.38; 95% CI = 1.43-3.97; P < 0.001) in Asian countries using ROME criteria’s subgroup. Normal weight patients were also more prevalent in non-FC patients in Asia (OR = 0.54; 95% CI = 0.38-0.76; P < 0.001). The relationship between FC and short stature is still inconclusive.Conclusions: FC is correlated with the prevalence of both overweight/obesity and undernutrition. Future studies should evaluate the causal relationship and whether FC treatment could help.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Protocolized Intervention for Children and Adolescents With Phagophobia

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      Authors: Begotka; Andrea; Silverman, Alan; Goday, Praveen
      Abstract: imageWe aimed to prospectively evaluate the effectiveness of a protocolized shaping intervention in children with phagophobia, which occurs when an aversive oral experience causes fear of swallowing and can result in restricted oral intake and weight loss. Twenty-one children (12 males) diagnosed with phagophobia (mean age 8.5 years) underwent initial medical workup and a pediatric psychologist driven shaping protocol. The outpatient protocol involved graduated food exposure with anxiety reduction strategies to eliminate anxiety and expand participants’ diet. The participants completed an average of 6 treatment sessions. Post-treatment, there was a significant increase in weight, total number of foods consumed, and number of foods consumed across food groups and texture. Additionally, self-reported subjective units of distress were low for all participants throughout treatment. We conclude that after appropriate medical workup behavioral treatment is safe and efficacious in children with phagophobia and returns children to premorbid functioning and diet.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Predictors of Perianal Fistula Healing in Children With Newly Diagnosed
           Crohn Disease

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      Authors: Singer; Andrew A. M.; Rompca, Annemarie; Gadepalli, Samir K.; Adler, Jeremy
      Abstract: imageObjectives: Perianal fistulas are among the most severe complications of Crohn disease, but limited data regarding their outcomes are available in children. Our objective was to determine predictors of perianal fistula healing among pediatric patients newly diagnosed with Crohn disease.Methods: This single-center retrospective study followed patients with perianal fistulas at Crohn disease diagnosis until fistula healing. Time to healing was analyzed using Cox proportional hazard regression models considering relevant covariates including patient demographics, disease characteristics, medical therapies [no anti-tumor necrosis factor (TNF)α therapy, anti-TNFα therapy ±therapeutic drug monitoring], and perianal surgical procedures including fistulotomy, fistulectomy, removal of perianal lesions, seton placement, and incision and drainage.Results: Of 485 patients identified, 107 (22%) had a perianal fistula at Crohn disease diagnosis. Multivariate analysis identified that perianal fistulotomy, fistulectomy, and lesion removal [hazard ratio (HR) 0.46; P = 0.028], non-White race (HR 0.30, P < 0.01), and male sex (HR 0.42; P = 0.02) were associated with delayed fistula healing. Faster fistula healing was associated with treatment with anti-TNFα with therapeutic drug monitoring (HR 1.78, P = 0.009). There were no other differences in healing by treatment.Conclusions: Fistulotomy, fistulectomy, and perianal lesion removal as well as non-White race were associated with delayed fistula healing. Anti-TNFα therapy was associated with faster fistula healing when combined with therapeutic drug monitoring, compared to all other medical treatment groups, including anti-TNFα therapy without therapeutic drug monitoring.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Safety and Potential Efficacy of Escalating Dose of Ustekinumab in
           Pediatric Crohn Disease (the Speed-up Study): A Multicenter Study from the
           Pediatric IBD Porto Group of ESPGHAN

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      Authors: Yerushalmy-Feler; Anat; Pujol-Muncunill, Gemma; Martin-de-Carpi, Javier; Kolho, Kaija-Leena; Levine, Arie; Olbjørn, Christine; Granot, Maya; Bramuzzo, Matteo; Rolandsdotter, Helena; Mouratidou, Natalia; Hradsky, Ondrej; Scarallo, Luca; Matar, Manar; Rimon, Ramit Magen; Rinawi, Firas; Shalem, Tzippi; Najajra, Hisham; de Meij, Tim; Aloi, Marina; Rodríguez-Belvís, Marta Velasco; Alvisi, Patrizia; Schneider, Anna-Maria; van Rheenen, Patrick; Navas-López, Víctor Manuel; Kiparissi, Fevronia; Barrio, Josefa; Turner, Dan; Cohen, Shlomi
      Abstract: imageObjectives: Escalation of the ustekinumab (UST) maintenance dosage was effective in adults with Crohn disease (CD), but no data are available for children. We evaluated the effectiveness and safety of dose escalation of UST in pediatric CD.Methods: This was a retrospective multicenter study from 25 centers affiliated with the IBD Interest and Porto groups of ESPGHAN. We included children with CD who initiated UST at a standard dosing and underwent either dose escalation to intervals shorter than 8 weeks or re-induction of UST due to active disease. Demographic, clinical, laboratory, endoscopic, imaging, and safety data were collected up to 12 months of follow-up.Results: Sixty-nine children were included (median age 15.8 years, interquartile range 13.8–16.9) with median disease duration of 4.3 years (2.9–6.3). Most children were biologic (98.6%)- and immunomodulator (86.8%)- experienced. Clinical response and remission were observed at 3 months after UST escalation in 46 (67%) and 29 (42%) children, respectively. The strongest predictor for clinical remission was lower weighted Pediatric Crohn Disease Activity Index (wPCDAI) at escalation (P = 0.001). The median C-reactive protein level decreased from 14 (3–28.03) to 5 (1.1–20.5) mg/L (P = 0.012), and the fecal calprotectin level from 1100 (500–2300) to 515 (250–1469) µg/g (P = 0.012) 3 months post-escalation. Endoscopic and transmural healing were achieved in 3 of 19 (16%) and 2 of 15 (13%) patients, respectively. Thirteen patients (18.8%) discontinued therapy due to active disease. No serious adverse events were reported.Conclusions: Two-thirds of children with active CD responded to dose escalation of UST. Milder disease activity may predict a favorable outcome following UST dose escalation.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Tofacitinib Salvage Therapy for Children Hospitalized for Corticosteroid-
           and Biologic-Refractory Ulcerative Colitis

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      Authors: Constant; Brad D.; Baldassano, Robert; Kirsch, Jacqueline; Mitchel, Elana B.; Stein, Ronen; Albenberg, Lindsey
      Abstract: imageObjectives: Colectomy rates following acute severe ulcerative colitis have plateaued around 20% despite intravenous corticosteroid and intensified anti-tumor necrosis factor (TNF) biologic dosing. Recent studies have shown tofacitinib to provide additional benefit in further decreasing colectomy rates among hospitalized adult patients with corticosteroid- and anti-TNF-nonresponsive ulcerative colitis. Pediatric data describing the effectiveness of tofacitinib for this indication does not yet exist. We aimed to describe the treatment courses and colectomy-free survival among pediatric patients treated with tofacitinib while hospitalized for refractory ulcerative colitis.Methods: We performed a retrospective single-center cohort study of consecutive hospitalized pediatric patients initiating tofacitinib for refractory ulcerative colitis from 2018 to 2021. The primary outcome was 90-day colectomy-free survival. Secondary outcomes included colectomy-free clinical remission, corticosteroid independence, colectomy-free tofacitinib drug-persistence, tofacitinib-related adverse events, and postoperative complications. Baseline characteristics and details of the timing and positioning of therapies utilized during hospitalization were described. Outcomes were described using counts, percentages, and Kaplan-Meier curves.Results: Eleven patients met inclusion criteria. All patients demonstrated nonresponse to both intravenous corticosteroids and anti-TNF therapy prior to tofacitinib initiation. Median hospitalization length was 22 days and mean maximum pediatric ulcerative colitis activity index during hospitalization was 68. Eight of 11 patients remained colectomy-free at 90 days following hospital admission and 6 remained colectomy-free over median 182-day follow-up, including 4 of whom remained on tofacitinib.Conclusions: Tofacitinib may represent a new treatment option for hospitalized pediatric patients with corticosteroid- and anti-TNF-nonresponsive ulcerative colitis. Future research is essential in determining the optimal positioning of these therapies.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Safety of Thioguanine in Pediatric Inflammatory Bowel Disease: A
           Multi-Center Case Series

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      Authors: Bayoumy; Ahmed B.; Jagt, Jasmijn Z.; van Wering, Herbert M.; de Ridder, Lissy; Hummel, Thalia; Wolters, Victorien M.; Stapelbroek, Janneke; Benninga, Marc A.; Mulder, Chris J.J.; de Boer, Nanne K.H.; de Meij, Tim G.J.; on behalf of the Kids with Crohn’s, Colitis (KiCC Working Group for Collaborative Paediatric IBD Research in the Netherlands
      Abstract: imageObjectives: Thioguanine (TG) has been shown as a safe alternative in adults with inflammatory bowel disease (IBD) who did not tolerate conventional thiopurines [azathioprine (AZA)/mercaptopurine]. However, data in pediatric IBD are scarce. Therefore, we aimed to assess the safety of TG as maintenance therapy.Methods: A retrospective, multicenter cohort study of children with IBD on TG was performed in the Netherlands. TG-related adverse events (AE) were assessed and listed according to the common terminology criteria for AE.Results: Thirty-six children with IBD (median age 14.5 years) on TG (median dose 15 mg/day) were included in 6 centers. Five AE occurred during follow-up [pancreatitis (grade 3), hepatotoxicity (grade 3) (n = 2), Clostridium difficile infection (grade 2), and abdominal pain (grade 2)]. All patients (n = 8) with a previously AZA-induced pancreatitis did not redevelop pancreatitis on TG.Conclusions: In pediatric IBD, TG seems a safe alternative in case of AZA-induced pancreatitis. Further research assessing long-term TG-related safety and efficacy is needed.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Drug-Related Adverse Events Necessitating Treatment Discontinuation in
           Pediatric Inflammatory Bowel Disease Patients

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      Authors: Salzmann; Medea; von Graffenried, Thea; Righini-Grunder, Franziska; Braegger, Christian; Spalinger, Johannes; Schibli, Susanne; Schoepfer, Alain; Nydegger, Andreas; Pittet, Valérie; Sokollik, Christiane; the Swiss IBD Cohort Study Group
      Abstract: imageObjectives: Inflammatory bowel disease (IBD) requires long-term drug therapy in most patients, posing a risk for adverse drug events with the need for discontinuation. In this study, we investigated adverse events (AE) necessitating drug discontinuation in pediatric and adolescent IBD patients.Methods: We used data prospectively collected from IBD patients below the age of 18 enrolled in the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS), namely demographic variables, medical characteristics, drug treatments, and related AE. We analyzed the frequency, type, and risk factors for AE necessitating drug discontinuation.Results: A total of 509 pediatric IBD patients fulfilled the inclusion criteria of which 262 (51.5%) were diagnosed with Crohn disease (CD), 206 (40.5%) with ulcerative colitis (UC), and 41 (8%) with IBD-unclassified (IBD-U). In total, 132 (25.9%) presented with at least 1 drug-related AE that required drug cessation. Immunomodulators [methotrexate 29/120 (24.2%), azathioprine 57/372 (15.3%)] followed by tumor necrosis factor (TNF)-alpha antagonists [adalimumab 8/72 (11.1%), infliximab 22/227 (9.7%)] accounted for the highest proportions of AE necessitating treatment discontinuation. Treatment schemes with at least 3 concomitant drugs significantly amplified the risk for development of drug-related AE [odds ratio = 2.50, 95% confidence interval (1.50–4.17)] in all pediatric IBD patients.Conclusions: Drug-related AE necessitating discontinuation are common in pediatric and adolescent IBD patients. Caution needs to be taken in the case of concomitant drug use.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Characteristics of Children With Inflammatory Bowel Disease and Coexisting
           Celiac Disease Seropositivity

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      Authors: Cheung; Telly; de Zoeten, Edwin F.; Hoffenberg, Edward J.; Liu, Edwin; Pan, Zhaoxing; Walker, Thomas; Stahl, Marisa
      Abstract: imageObjectives: Celiac disease (CeD) autoimmunity and coexisting inflammatory bowel disease (IBD) present a diagnostic dilemma. Our aims were to describe the phenotype of children with IBD and CeD seropositivity and evaluate provider confidence for diagnosing CeD in this population.Methods: We performed a single-center retrospective cohort study of subjects ≤18 years old with IBD and CeD seropositivity between 2006 and 2020. Subjects were considered to have IBD-CeD if they met CeD diagnosis by serology and histology per North American Society For Pediatric Gastroenterology, Hepatology and Nutrition guidelines and if providers suspected CeD as evaluated by a survey. The IBD-only cohort included seropositive participants that did not meet criteria for CeD. Demographic, histologic, gross endoscopic, and laboratory features were compared using Fisher exact test.Results: Of 475 children with IBD, 8 had concomitant CeD, 5 had tissue transglutaminase (tTG) immunoglobulin A (IgA)> 10x upper limit of normal (ULN, P = 0.006), and 8 had villous atrophy (VA, P = 0.003) when compared with 17 seropositive participants with IBD-only. No children with IBD-CeD had esophageal eosinophilia, duodenal cryptitis, duodenal ulceration, or fecal calprotectin>250 µg/g. Factors that contributed to provider uncertainty for diagnosing CeD in IBD included the absence of VA and intraepithelial lymphocytes, the presence of neutrophilic and eosinophilic duodenitis, diffuse ulceration, elevated inflammatory markers, and immunosuppression therapy.Conclusions: Diagnosing CeD in children with IBD continues to be challenging. Although high titers of tTG IgA and VA increased provider confidence for diagnosing CeD in IBD, development of evidence-based guidelines are needed. They should better assess the importance of features atypical of concomitant CeD that contribute to uncertainty.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Correlation of Anti-Tissue Transglutaminase Antibodies With the Mucosal
           Changes and IgA Status of Children With Celiac Disease

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      Authors: Donat; Ester; Roca, María; Castillejo, Gemma; Sánchez-Valverde, Félix; García-Burriel, Jose Ignacio; Martínez-Ojinaga, Eva; Eizaguirre, Francisco Javier; Barrio, Josefa; Cilleruelo, Mª Luz; Pérez-Solís, David; Ochoa-Sangrador, Carlos; Vecino-López, Raquel; Miranda-Cid, Mª del Carmen; García-Calatayud, Salvador; Torres-Peral, Ricardo; Juste, Mercedes; Armas, Honorio; Barros-García, Patricia; Leis, Rosaura; Solaguren, Rosa; Salazar, José Carlos; García-Romero, Ruth; Ortigosa, Luis; Peña-Quintana, Luis; Urruzuno, Pedro; Codoñer-Franch, Pilar; Garcia-Casales, Zuriñe; Masiques, Maria Llüisa; Galicia-Poblet, Gonzalo; Crehuá-Gaudiza, Elena; Balmaseda, Elena; Rubio-Santiago, Javier; Polanco-Allué, Isabel; Román-Riechmann, Enriqueta; Ribes-Koninckx, Carmen; Coeliac Disease Working Group of the Spanish Gastroenterology, Hepatology, Paediatric Nutrition Society (SEGHNP
      Abstract: imageObjectives: The objective of this study was to assess the association between serological markers and changes of the intestinal mucosa in children with celiac disease (CD).Methods: Clinical data from CD patients under 15 years old were collected from the participating centers in an on-line multicenter nationwide observational Spanish registry called REPAC-2 (2011–2017). Correlation between anti-tissue transglutaminase antibodies (t-TGA) levels and other variables, including mucosal damage and clinical findings (symptoms, age, and gender), was assessed.Results: A total of 2955 of 4838 patients had t-TGA and a small bowel biopsy (SBB) performed for CD diagnosis. A total of 1931 (66.2%) patients with normal IgA values had a Marsh 3b-c lesion and 1892 (64.9%) had t-TGA Immunoglobulin A (IgA) ≥ 10 times upper limit of normal (ULN). There is a statistically significant association between t-TGA IgA levels and the degree of mucosal damage (P < 0.001), the higher the t-TGA IgA levels the more severe the mucosal damage. Those patients who reported symptoms had more severe mucosal damage (P = 0.001). On the contrary, there was a negative association between age and changes of the intestinal mucosa (P < 0.001). No association was found with gender. Regarding the IgA-deficient patients, 47.4% (18 cases) had t-TGA Immunoglobulin A (IgA) ≥ 10 times ULN and a Marsh 3b-c lesion was observed in 68.4% (26 patients). No statistical relation was found between t-TGA IgG levels and the changes of the intestinal mucosa, neither a relation with age, gender, or symptoms.Conclusions: There is a positive correlation between t-TGA IgA levels and the severity of changes of the intestinal mucosa. Such correlation was not found in IgA-deficient patients who had positive t-TGA IgG serology. The results in this group of patients support the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition recommendations about the need of performing a SBB in IgA-deficient individuals despite high t-TGA IgG levels.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Pancreatitis in the Complex Care Population: Presentation, Incidence, and
           Severity

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      Authors: Hawa; Kathryn; Corker, Lisa; Hornung, Lindsey; Noritz, Garey; Gariepy, Cheryl; Shaikhkhalil, Ala; Abu-El-Haija, Maisam
      Abstract: imageObjectives: To describe the incidence and presentation of pancreatitis in Children with Medical Complexity (CMC) while evaluating severity of disease and outlining risk factors.Methods: This was a retrospective chart review between January 2010 and December 2019 of patients seen in the complex care clinic at Nationwide Children’s Hospital (NCH) and Cincinnati Children’s Hospital Medical Center (CCHMC). Data collected included sex, underlying diagnosis, family history of pancreatitis, type of pancreatitis, signs/symptoms, abdominal imaging, severity of attack, and presence of various risk factors associated with pancreatitis. Severity and diagnosis of pancreatitis was determined based on North American Society for Pediatric Gastroenterology, Hepatology and Nutrition criteria.Results: One hundred and twelve patients from both institutions were included, 62% from NCH, median age 11.5 [interquartile range (IQR): 5–16 years], 50% male. Most patients were less than 18 years of age with a median age of 8 years (IQR: 4–13 years). Underlying diagnoses included seizures (67%), cerebral palsy/spastic quadriplegia (65%), diabetes (3.6%), and mitochondrial disease (3%). Majority of patients were found to have multiple underlying diagnoses (88%). Incidence of pancreatitis for both institutions was 336 of 100,000 patients/year which is significantly higher than the general pediatric population (P < 0.0001). Majority of first episodes of pancreatitis were mild (82%) with abdominal pain as the predominant symptom (50%). Adult patients were more likely to have pancreatitis related to medication use than pediatric patients (70% vs 38%, respectively P = 0.007).Conclusions: Individuals in the CMC population at our institutions have a high incidence of pancreatitis with unique risk factors compared to the general pediatric/young adult populations.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Technical Outcomes in Pediatric Endoscopic Retrograde
           Cholangiopancreatography: Data from an International Collaborative

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      Authors: Troendle; David M.; Ruan, Wenly; Fishman, Douglas S.; Barth, Bradley A.; Liu, Quin Y.; Giefer, Matthew; Kim, Kyung Mo; Martinez, Mercedes; Dall’oglio, Luigi; Torroni, Filippo; De Angelis, Paola; Faraci, Simona; Bitton, Sam; Wilsey, Michael; Khalaf, Racha; Werlin, Steven; Dua, Kulwinder; Gugig, Roberto; Huang, Clifton; Mamula, Petar; Quiros, J. Antonio; Zheng, Yuhua; Grover, Amit; Fox, Victor L.
      Abstract: imageObjectives: Endoscopic retrograde cholangiopancreatography (ERCP) in adults has been extensively studied through multicenter prospective studies. Similar pediatric studies are lacking. The Pediatric ERCP Database Initiative (PEDI) is a multicenter collaborative aiming to evaluate the indications and technical outcomes in pediatric ERCPs.Methods: In this prospective cohort study, data were recorded for pediatric ERCPs performed across 15 centers. A pre-procedure, procedure, 2-week post-procedure follow-up, and adverse event form were completed for each ERCP performed. Univariate and stepwise linear regression was performed to identify factors associated with technically successful procedures and adverse events.Results: A total of 1124 ERCPs were performed on 857 patients from May 1, 2014 to May 1, 2018. The median age was 13.5 years [interquartile range (IQR) 9.0–15.7]. Procedures were technically successful in the majority of cases (90.5%) with success more commonly encountered for procedures with biliary indications [odds ratio (OR) 4.2] and less commonly encountered for native papilla anatomy (OR 0.4) and in children
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Magnetic Resonance Imaging to Assess Body Composition Change in
           Adolescents With Obesity After Sleeve Gastrectomy

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      Authors: Berg; Elizabeth A.; Huang, Zixing; Wang, Youya; Baidal, Jennifer Woo; Fennoy, Ilene; Lavine, Joel E.; Zitsman, Jeffrey; Shen, Wei
      Abstract: imageObjectives: Metabolic and bariatric surgery is the most effective weight loss treatment for severe obesity. The number of adolescents undergoing sleeve gastrectomy is increasing. We investigated changes in body composition in adolescents undergoing sleeve gastrectomy 12–26 weeks post-operatively using whole-body magnetic resonance imaging (WB-MRI).Methods: This prospective cohort study assessed changes in adipose tissue compartments (ie, visceral, subcutaneous, and intermuscular) and muscle in 18 obese adolescents, ages 14–19, 89% female, with body mass index z-score of 2.6 ± 0.25 (range 2.16–3.2). All underwent WB-MRI 1.5–17 weeks pre-operatively and 12–26 weeks post-operatively.Results: Pre- and post-operative WB-MRI showed decreases in all adipose tissue compartments, as well as decreased skeletal muscle and liver fat fraction (P < 0.0001). The post-operative percentage loss of adipose tissue in subcutaneous, visceral, and intermuscular compartments (89.0%, 5.8%, 5.2%, respectively) was similar to the pre-operative percentages of corresponding adipose tissue compartments (90.5%, 5.0%, 4.5%, respectively). Of note, participants with obstructive sleep apnea had significantly higher pre-operative volume of subcutaneous and intermuscular adipose tissue than participants without obstructive sleep apnea (P = 0.003).Conclusions: We found, contrary to what is reported to occur in adults, that pre-operative percentage loss of adipose tissue in subcutaneous, visceral, and intermuscular compartments was similar to the post-operative percentage loss of corresponding adipose tissue compartments in adolescents 12–26 weeks after sleeve gastrectomy.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Enteric Permeability, Systemic Inflammation, and Post-Discharge Growth
           Among a Cohort of Hospitalized Children in Kenya and Pakistan

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      Authors: Tickell; Kirkby D.; Denno, Donna M.; Saleem, Ali; Ali, Asad; Kazi, Zaubina; Singa, Benson O.; Otieno, Catherine; Mutinda, Charles; Ochuodho, Victor; Richardson, Barbra A.; Ásbjörnsdóttir, Kristjana H.; Hawes, Stephen E.; Berkley, James A.; Walson, Judd L.
      Abstract: imageObjectives: To determine whether gut permeability is associated with post-discharge growth and systemic inflammation among hospitalized children in low- and middle-income countries.Methods: Children aged 2–23 months being discharged from Civil Hospital Karachi (Pakistan) and Migori County Referral Hospital (Kenya) underwent lactulose-rhamnose ratio (LRR) permeability testing and were compared to age-matched children from their home communities. Linear mixed effect models estimated the associations between LRR among discharged children with change in length-for-age (LAZ) and weight-for-age z score (WAZ) at 45, 90, and 180 days after discharge. Linear regression tested if relationships between LRR, systemic inflammation [C-reative protein (CRP), Cluster of Differentiation 14 (CD14), Tumour Necrosis Factor Alpha (TNFα), Interleukin-6 (IL-6)], and enterocyte damage [Intestinal Fatty-Acid Binding protein (I-FABP)] differed between the hospitalized and community groups.Results: One hundred thirty-seven hospitalized and 84 community participants were included. The hospitalized group had higher log-LRR [0.43, 95% confidence interval (CI): 0.15–0.71, P = 0.003] than the community children. Adjustment for weight-for-length z score at discharge attenuated this association (0.31, 95% CI: 0.00–0.62, P = 0.049). LRR was not associated with changes in WAZ or LAZ in the post-discharge period. Associations between LRR and CRP (interaction P = 0.036), TNFα (P = 0.017), CD14 (P = 0.078), and IL-6 (P = 0.243) differed between community and hospitalized groups. LRR was associated with TNFα (P = 0.004) and approached significance with CD14 (P = 0.078) and IL-6 (P = 0.062) in community children, but there was no evidence of these associations among hospitalized children.Conclusions: Although increased enteric permeability is more prevalent among children being discharged from hospital compared to children in the community, it does not appear to be an important determinant of systemic inflammation or post-discharge growth among hospitalized children.
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • EBV-Positive Mucocutaneous Ulcer in Pediatric Crohn Disease—The
           Importance of Pathology

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      Authors: Granot; Maya; Haberman, Yael; Schiby, Ginette; Weiss, Batia
      Abstract: imageNo abstract available
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Diffuse Esophageal Papillomatosis

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      Authors: Bashir; Anam; Suchi, Mariko; Martinez, Alfonso M.
      Abstract: imageNo abstract available
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Eosinophilic Esophagitis After Pediatric Hematopoietic Stem Cell
           Transplantation

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      Authors: Cheung; Donna; Katz, Daphna T.; Webster-Carrion, Andrea; Saad, Ali G.; Fifi, Amanda; Llanos-Chea, Alejandro; Pillai, Asha B.
      Abstract: imageNo abstract available
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
  • Taurolidine Versus Ethanol Central Line Locks for Children on Parenteral
           Nutrition

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      Authors: Vernon-Roberts; Angharad; Lopez, Robert N.; Day, Andrew S.
      Abstract: No abstract available
      PubDate: Thu, 01 Dec 2022 00:00:00 GMT-
       
 
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