Abstract: Abstract The present study was conducted to investigate the impact of mustard oil ingestion on thyroid hormones in experimental rats .Forty-two adult male albino rats (180± 5 g) were divided into 7 groups. Group (1) (-ve control) rats were fed on basal diet. Groups 2-4 were rendered hypothyroidism (injected with PTU, ip), where G2 fed on basal diet and G 3& 4 were given mustard oil at two levels (1&2 ml/Kg Bwt.), respectively. Groups 5-7 were rendered hyperthyroidism (injected with L-thyroxin, ip), where G5 was fed on basal diet and G6& 7 were given mustard oil at the same two levels, respectively. At the end of the experimental period (8 weeks), rats were sacrificed and blood samples were collected for serum. Thyroid hormones, liver and kidney functions were determined. Results indicated that, hypothyroid rats showed significant reduction in FT3 and FT4 levels, however, TSH level was significantly increased compared to the healthy group. Ingestion of mustard oil at the two levels of intake improve in hypothyroid status as related to significant increase in serum concentration of FT3 and FT4 and significant reduction of the level of TSH. While hyperthyroid rats showed significant increase in FT4 and FT3 levels. TSH level was significantly increased. Ingestion of mustard oil at the two levels caused lower in hyperthyroid status as related to significant decreased in the concentration of FT4 and FT3 and significant increase of the level of TSH. It was also observed that ingestion of mustard oil improve kidney function by reducing creatinine and urea concentrations in serum in the hypo and hyperthyroidism. Resuts revealed that mustard oil had beneficial effect on AST activity in rats with hypo and hyperthyroidism. Our results concluded that mustard oil ingestion improves thyroid hormones, liver and kidney functions. Thus, it could be recommended for patients with thyroid dysfunctions.
Abstract: Abstract Helicobacter pylori (H. pylori) infection affects nearly 50% of the human population reaching an incidence rate of about 70% in developing countries. Egypt is one of the highest endemic areas for this infection. H. pylori infection is associated with gastro-intestinal and extra gastric diseases. Type two diabetes mellitus (T2DM) is the prevalent type of DM reaching about 90%, WHO predicting the number of patients to be 438 million by year 2030. Inflammation is the playing factor in the etiology of DM and insulin resistance. H pylori could be the source of infection. AIM To detect the effect of H pylori eradication on glycemic control in T2DM on insulin therapy with and without diet planning. METHODS A randomized controlled clinical trial involving 68 well known T2DM patients on insulin therapy proved H pylori positive by detection of antigens in the stool. Those patients were recruited from the outpatient clinics of the National Research Centre. The patients were randomized into 4 equal groups; Group 1 (M) received their routine medical treatment only, group 2 (MD) received medical treatment and individualized planned dietary regimen, group 3 (MH) received medical and anti-H pylori treatment while group 4 (MHD) received medical, anti-H pylori treatment and dietary regimen. Initial baseline evaluation included: diabetes panel, lipid profile, liver enzymes, renal functions and BMI which is repeated at the end of 6 months follow up. RESULTS A significant decrease of mean FBG, PPBG and HbA1c levels at the end of 6 months intervention from baseline levels in the 4 groups, however the mean difference increased from group 1 to group 4. Mean BMI and Uric acid significantly decreased in all groups except group-M. Cholesterol and triglycerides significantly decreased in all groups. Non-statistically significant changes regarding ALT, AST and serum creatinine were observed in all groups.
Abstract: This research aimed to assess the nutritional status of women with breast cancer under chemotherapy. The study was carried out on a total sample of 57 patients receiving chemotherapy treatment; a total number of 27 patients were selected from hospital in Cairo. represented as urban patients, and A number of 30 were selected from Al-Gharbia Governorate, represented as rural patients. Their age ranged 40-50 years. The nutritional status was evaluated by using questionnaires 24 hours recall method, diet history, food frequency questionnaire, and subjective global assessment questionnaire. Clinical assessment was tested by Laboratory investigations. Results revealed that the patients from urban area had lower percentage in total caloric intake (55%), compared to the patients from rural area (81%). Fat and protein intake were higher among urban patients than rural patients. While all tested patients had deficiency in protein, fibers, vitamin A, C, calcium and iron. Data revealed that total patient’s sample were assessed by (SGA) were nutritionally at risk, regarding the socioeconomics level Results revealed that urban patients had higher significant value than rural patients. The patients in urban community had 75% of total score, while the patients live in rural had 59%. In conclusion all samples were deficient in macronutrients and micronutrients. While their intake from Macronutrients were within the normal range, but generally they had a total decrease in their calories intake, and micronutrients intake. Because of that It is recommended that following the appropriate dietary patterns will lead to improvement in chemotherapy treatment outcomes; improve overall health.
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