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Nutrition and Metabolic Insights
Journal Prestige (SJR): 0.331
Citation Impact (citeScore): 2
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1178-6388
Published by Sage Publications Homepage  [1174 journals]
  • Alteration in Plasma Metabolome in High-Fat Diet-Fed Monocyte Chemotactic
           Protein-1 Knockout Mice Bearing Pulmonary Metastases of Lewis Lung

    • Authors: Lin Yan, Bret M Rust, Sneha Sundaram, Matthew J Picklo, Michael R Bukowski
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Both clinical and laboratory studies have shown that monocyte chemotactic protein-1 (MCP-1) is involved in cancer spread. To understand the role of MCP-1 in metabolism in the presence of metastasis, we conducted an untargeted metabolomic analysis of primary metabolism on plasma collected from a study showing that MCP-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma (LLC) to the lungs in mice fed a high-fat diet (HFD). In a 2 × 2 design, wild-type (WT) or Mcp-1 knockout (Mcp-1-/-) mice maintained on the AIN93G standard diet or HFD were subcutaneously injected with LLC cells to induce lung metastasis. We identified 87 metabolites for metabolomic analysis from this study. Amino acid metabolism was altered considerably in the presence of LLC metastases with the aminoacyl-tRNA biosynthesis pathways as the leading pathway altered. The HFD modified lipid and energy metabolism, evidenced by lower contents of arachidonic acid, cholesterol, and long-chain saturated fatty acids and higher contents of glucose and pyruvic acid in mice fed the HFD. These findings were supported by network analysis showing alterations in fatty acid synthesis and glycolysis/gluconeogenesis pathways between the 2 diets. Furthermore, elevations of the citrate cycle intermediates (citric acid, fumaric acid, isocitric acid, and succinic acid) and glyceric acid in Mcp-1-/- mice, regardless of diet, suggest the involvement of MCP-1 in mitochondrial energy metabolism during LLC metastasis. The present study demonstrates that MCP-1 deficiency and the HFD altered plasma metabolome in mice bearing LLC metastases. These findings can be useful in understanding the impact of obesity on prevention and treatment of cancer metastasis.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-08-04T11:22:41Z
      DOI: 10.1177/11786388221111126
      Issue No: Vol. 15 (2022)
  • A review of the anti-diabetic potential of saffron

    • Authors: Anis Sani, Ali Tajik, Seiied Sina Seiiedi, Razieh Khadem, Haniye Tootooni, Mohammadhossein Taherynejad, Nasim Sabet Eqlidi, Seyyed mohammad matin Alavi dana, Niloofar Deravi
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron (Crocus sativus L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-07-27T11:16:08Z
      DOI: 10.1177/11786388221095223
      Issue No: Vol. 15 (2022)
  • Association Between Dietary Quality Indices and Atherosclerosis Risk: A
           Case-Control Study

    • Authors: Mahsa Samadani, Anahita Mansoori, Habib Haybar, Fatemeh Haidari, Majid Mohammadshahi
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Several diet quality scores have been developed to evaluate the health benefits of individual diets such as Healthy Eating Index (HEI), Dietary Approach to Stop Hypertension (DASH), and Mediterranean diet score (Med). This study aims to determine the relationship between dominant dietary health scores with the risk of atherosclerosis in Iranian adults.Methods:This case-control study was conducted on 323 patients with atherosclerosis and 334 individuals without atherosclerosis as control group. Food Frequency Questionnaire was used for obtaining dietary intakes; then HEI, DASH score, and Med score was calculated. Logistic regression models were used to calculate Odds Ratios (OR) and 95% Confidence intervals (CI) between quartiles of the HEI, DASH and Med and atherosclerosis risk.Results:The results showed that total scores for HEI, DASH, and Med in control group was higher than the atherosclerosis group. The results also indicated that higher adherence to HEI (OR: 0.43; CI: [0.24, 0.76], P-trend = .006), DASH (OR: 0.48; CI: [0.3, 0.78], P-trend = .003), and Mediterranean pattern (OR: 0.4; CI: [0.21, 0.76]) decreased odds ratio of atherosclerosis.Conclusion:Our findings suggest that adherence to HEI, DASH, and Mediterranean diet might be associated with a lower risk of Atherosclerosis and can have a positive effect on general health and prevention of chronic diseases in people.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-07-19T07:38:43Z
      DOI: 10.1177/11786388221111934
      Issue No: Vol. 15 (2022)
  • Practice of Sunlight Exposure of Infants and Associated Factors Among
           Infant Coupled Mothers at Dejen District, Amhara Region, Northwest
           Ethiopia 2021

    • Authors: Amare Bekalu, Abebaw Molla, Bayachew Asmare, Yidersal Hune, Habtamu Temesgen
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Introduction:Currently, nutritional rickets has become a concern of many nutrition experts in many countries. Sunlight is the best and most reliable Source of vitamin D. Since, there is scarce information regarding infant sunlight exposure practice and the determinant factors. Hence, this study aimed to assess mothers’ infant sunlight exposure, practice level, and associated factors.Methods:A community-based cross-sectional study was conducted on 884 mothers from March 20 to April 4, 2017. Through the multi-stage simple random sampling method, the study areas had selected. The data were collected using a structured and pre-tested questionnaire and were entered into Epidata version 3.1 and exported to SPSS version 20 for analysis. The strength of association was measured using binary logistic regression at a 95% CI odds ratio. Finally, P 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-30T12:25:25Z
      DOI: 10.1177/11786388221106983
      Issue No: Vol. 15 (2022)
  • The Effect of Flaxseed Oil Supplementation on Body Composition and
           Inflammation Indices in Overweight Adults With Pre-Diabetes

    • Authors: Elham Shareghfarid, Azadeh Nadjarzadeh, Neda Heidarzadeh-Esfahani, Yasaman Azamian, Salimeh Hajiahmadi
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Flaxseed has rich content of alpha linolenic acid for preventing pro inflammatory process. The aim of present study is exploring the effect of flaxseed oil supplementation on inflammatory biomarkers and body composition in overweight adults with pre-diabetes.Material and methods:this double-blind randomized clinical trial conducted with 80 overweight pre-diabetic patients in 2 clusters (flaxseed oil group (2000-mg daily) and control group) across a 14-week period. Anthropometric indices, body composition and inflammatory indices were measured between 2 groups before and after the treatment.Result:this study found a significant decrease in visceral fat level in the intervention group (P = .009) and control group (P = .004) at the end of the survey. However, the mean change of it (P = .06) was not significant. Also, this study showed that percentage of body fat (P = .31) and its mean change (P = .6) did not have significantly different between the 2 groups at the 14th week. The skeletal muscle% had a significant rise in the intervention group (P = .005) and control group (P = .003) by the end of 14th week. However, the mean change of it (P = .19) was not significant between the 2 groups. In addition, there was no significant change in the fasting blood glucose (P = . 7), C reactive protein (P = .12) and TNF-α (P = .22) between the 2 groups at the end of study.Conclusion:It showed that flaxseed oil supplementation cannot improve body composition and inflammation.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-30T05:35:54Z
      DOI: 10.1177/11786388221090083
      Issue No: Vol. 15 (2022)
  • Effect of Psyllium husk fiber and lifestyle modification on human body
           insulin resistance

    • Authors: Amjad Ali Bacha, Zia Ud Din, Imran khan
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Insulin resistance is a metabolic disorder that is increasing worldwide and is associated with some of the most common diseases affecting modern societies including diabetes, hypertension, obesity, and coronary heart disease. Changes in diet and physical activity have a profound effect on lowering the risk and cost of managing insulin resistance compared to the pharmacological approach. An interventional study of 16 weeks explored the effect of Psyllium husk fiber in combination with lifestyle modification on insulin resistance among the centrally obese school teachers of district Malakand Khyber Pakhtunkhwa. One Hundred twenty school teachers with central obesity, aged 40-60 years, with no chronic disease history were divided into four subgroups (n = 30) with equal gender bifurcation; a control group, lifestyle modification (LSM) group, psyllium husk fiber (PSH) group, and the combined intervention of LSM & PSH group. Fasting serum was collected to analyze fasting blood glucose, and insulin resistance by using the HOMA-IR method at baseline and post-intervention. A significant effect of the intervention was observed on fasting blood glucose. The combined group of LSM&PSH showed the highest mean change of −7.5 ± 2.6 mg/dl (−9%), followed by the PSH group with a mean change of −6.3 ± 2.1 mg/dl, (−7%). Likewise a significant effect (P 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-24T07:05:40Z
      DOI: 10.1177/11786388221107797
      Issue No: Vol. 15 (2022)
  • Adherence to the Mediterranean Diet of Pregnant Women in Central South
           Africa: The NuEMI Study

    • Authors: Hermina Catharina Spies, Mariette Nel, Corinna May Walsh
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Introduction:The Mediterranean diet (MeD) has been shown to have significant health benefits for adults and children. A mother’s diet during pregnancy directly impacts the health of her offspring. This study aimed to investigate the adherence to the MeD of pregnant women attending antenatal care at a Regional Hospital in Bloemfontein, South Africa (SA).Methods:A cross-sectional study was conducted on a consecutive sample of 681 pregnant women who attended the antenatal clinic of a Regional Hospital in Bloemfontein. Socio-demographics included: age, highest level of education, household income, employment status, and income stability. Food group intake was assessed with a quantitative food frequency questionnaire. The adapted Mediterranean Diet Adherence Screener (MeDAS) consisted of 13 of the original 14 questions that measured intake of key food groups (score of ⩽7 poor, 8-9 moderate, ⩾10 good) (wine intake was excluded for pregnant women).Results:A total of 681 pregnant women with a median age of 31.8 years (IQR: 26.8-36.5 years) and a median gestational age of 32.0 weeks at the time of the interview participated in the study. The vast majority showed poor adherence to the MeD (99.6%), with only 0.4% (n = 3) having moderate adherence and 0% good adherence. The median adherence score was 5 points and the maximum 8 points. Of those with poor adherence, only 11.5% had tertiary education, 43.2% earned less than R 3000 (
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-24T07:02:26Z
      DOI: 10.1177/11786388221107801
      Issue No: Vol. 15 (2022)
  • Chronic Uptake of A Probiotic Nutritional Supplement (AB001) Inhibits
           Absorption of Ethylalcohol in the Intestine Tract – Results from a
           Randomized Double-blind Crossover Study

    • Authors: Andreas Pfützner, Mina Hanna, Yuriko Andor, Daniela Sachsenheimer, Filiz Demircik, Tobias Wittig, Johan de Faire
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Regular alcohol consumption, e.g. by social drinking, is a potential source of consecutive health problems in many countries worldwide. A probiotic nutritional supplement (AB001) has been developed to reduce alcohol absorption from the intestine tract and to mitigate potential health care risks.Methods:This randomized placebo-controlled double-blind crossover study was conducted with 24 healthy subjects (13 male, 11 female, age: 25.4 ± 7.7 years, BMI: 23.6 ± 2.5 kg/m²). The subjects were randomized to take 2 capsules/day of AB001 or placebo for 1 week prior to an alcohol exposure experiment. On the experimental day, they ingested a light breakfast and drank a moderate glass of spirit (0.3 g/kg body weight). Breath alcohol tests and blood draws for determination of blood alcohol levels were performed for up to 6 hours. After crossover, the experiment was repeated in the following week. Areas under the curves were calculated to determine alcohol absorption rates.Results:A significant reduction of blood alcohol levels by 70.3% (P 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-24T06:58:04Z
      DOI: 10.1177/11786388221108919
      Issue No: Vol. 15 (2022)
  • Animal-Based Dietary Protein Intake Is Not A Risk Factor For Metabolic
           Syndrome Among Young Or Middle-Aged Females

    • Authors: Bailee Sawyer, Kara A. Stone, Christopher J. Kotarsky, Nathaniel Johnson, Adam Bradley, Rachel A. Scheffert, Kyle J. Hackney, Wonwoo Byun, Sherri Stastny
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Metabolic syndrome (MetS) increases risk for morbidity and premature mortality. Blood pressure, waist circumference, and fasting triglycerides (TG), blood glucose (BG), and high-density lipoprotein cholesterol (HDL) are factors for determining MetS. The Simple Method for Quantifying Metabolic Syndrome (siMS) score and risk score estimate risk of MetS. The purpose for this study was to exam the relationship of animal-based (ABP) and plant-based protein (PLP) with MetS as estimated by siMS score and risk score. Physical activty is another important consideration in MetS as it can reduce blood pressure, waist circumference and blood glucose, and affect blood lipid and lipoprotein concentrations.Methods:A cross-sectional study examined whether physical activity (PA) level and dietary protein source (i.e., animal- or plant-based) among young (18-24 years) and middle-aged (45-60 years) females were associated with siMS score and siMS risk score. Average time spent in sedentary, light, and moderate-to-vigorous PA (MVPA; min/wk), steps (steps/day), energy intake (kcal/day), percent dietary protein to total energy intake, ABP and PLP dietary intake, and ABP:PLP ratio (g/day) were included in the analysis. Volunteers were recruited from North Dakota and Minnesota from 2017 to 2019.Results:Eighty-one female participants (mean ± SD; young, n = 38, 20.4 ± 1.7 years, middle-aged, 52.5 ± 4.8 years) were included in the independent t-tests used to examine group differences in age, body mass index, HDL, BG, TG, systolic blood pressure, waist circumference, energy intake, energy intake percentage of total carbohydrates, fat, protein, ABP, and PLP, ABP:PLP, siMS score, and siMS risk score. Stepwise linear regressions were used to evaluate whether PA level and dietary protein source were predictors of siMS score and siMS risk score among young and middle-aged adult females. There was an inverse relationship between PLP intake and siMS score. The model explained 6.9% of the variance in siMS risk score (F1, 80 = 5.93). Plant-based protein intake was inversely related to siMS risk score while light PA was positively associated with siMS risk score. The model explained 16% of the variance in siMS risk score (F1, 80 = 7.53). Animal-based dietary protein intake did not impact siMS score (p = 0.180) and siMS risk score (p = 0.283).Conclusions:Plant-based protein intake was associated with a lower risk of MetS via siMS scores, while ABP was not associated. Given the nature of the cross-sectional design of this study, no causal relationship can be determined, but longitudinal studies or randomized control trials to confirm the results from this study are needed in the future.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-24T06:56:41Z
      DOI: 10.1177/11786388221107800
      Issue No: Vol. 15 (2022)
  • Time to Recovery and Determinants of Uncomplicated Severe Acute
           Malnutrition Among 6 to 59 Months Children From the Outpatient Therapeutic
           Feeding Program in North Shewa Zone of Oromia Region, Ethiopia: A
           Prospective Follow-up Study

    • Authors: Amare Bekalu, Degemu Sahlu, Addisu Waleligne Tadesse, Biachew Asmare, Yidersail Hune, Bayou Tilahun
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Community-based management of acute malnutrition is implementing in Ethiopia but there is scarce information in our study set up regarding the time to recovery and its predictors of severe acute malnutrition among 6 to 59 months children, so this study aimed to assess the time to recovery and its predictors for uncomplicated severe acute malnutrition among 6 to 59 children managed at the outpatient therapeutic program in north Shewa zone, Ethiopia.Methods:A health post-based prospective follow-up study was conducted on 6 to 59 months children from November 20/2020 to February 20/2021. A total of 423 children had included in the study. A structured interviewer-administered questionnaire had used. The median time to recovery had calculated using the Kaplan-Meier curve. Bi-variable and multi-variable Cox regression models with a 95% confidence interval (CI) were done. Finally, the variable that had a P-value 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-20T06:27:34Z
      DOI: 10.1177/11786388221106984
      Issue No: Vol. 15 (2022)
  • The Interaction Between Dietary Total Antioxidant Capacity and MC4R Gene
           and HOMA-IR in Metabolically Healthy and Unhealthy Overweight and Obese

    • Authors: Maryam ElhamKia, Leila Setayesh, Habib Yarizadeh, Sara Pooyan, Zahra Veisy, Vajihe Aghamohammadi, Krista Casazza, Khadijeh Mirzaei
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Introduction:The current prevalence of the metabolically healthy obesity is about 3%. Genetic and nutrition are influencers of such phenotypes. The main goal of this study was to assess the interaction between Dietary Total Antioxidant Capacity (DTAC) and the genotypes of MC4R and Insulin resistance in metabolically healthy/unhealthy overweight and obese women in Iran.Material And Methods:This cross-sectional study was conducted on 237 overweight-obese women with a mean age of 36. The value of Dietary total antioxidant capacity (DTAC) was calculated using the following indices: Total reactive antioxidant potential (TRAP), Trolox equivalent antioxidant capacity (TEAC), and ferric reducing ability of plasma (FRAP). The Metabolic health status was evaluated using the Karelis criteria. Melanocortin 4 receptor single nucleotide polymorphisms were determined by the restriction fragment length polymorphism (PCR-RFLP) method. Also, insulin resistance was evaluated through homeostasis model assessment (HOMA).Result:Our data noted that 72.96% of participants presented Unhealthy Metabolically and 26.94% Healthy Metabolically including 33.5% of the total had T/T genotype, 23.8% had the C/T genotype, and 42.5% had the C/C genotype (P = .05). A linear regression model test showed that the probability of metabolically healthy obesity was significantly higher in patients with the T/C genotype. The test value was statistically significant (95% CI: 0.000-0.001; P = .056, β = 0). No statistically significant relation was observed between study parameters and DTAC values. HOMA-Index was higher in all unhealthy subjects significantly.Conclusions:The findings indicated that there are significant associations between genotypes of rs1333048 SNP and DTAC. The C/C genotype subjects with higher DTAC had a better lipid profile and were metabolically healthier.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-17T06:04:45Z
      DOI: 10.1177/11786388221105984
      Issue No: Vol. 15 (2022)
  • Anemia and Associated Factors Among Lactating Women in Sierra Leone: An
           Analysis of the Sierra Leone Demographic and Health Survey 2019

    • Authors: Ivan Kato Arinda, Quraish Sserwanja, Kassim Kamara, David Mukunya, Napyo Agnes, Nsubuga Edirisa Juniour, Nuwahereza Christinah, Anitah Kagali, Seungwon Lee
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Anemia is a condition in which hemoglobin (Hb) concentration and/or red blood cell (RBC) numbers are lower than normal and insufficient to meet an individual’s physiological needs. The prevalence of anemia among women of reproductive age is high in Sub-Saharan Africa (SSA), including Sierra Leone. However, data on anemia among lactating women in Sierra Leone are scarce. Therefore, this study was conducted to estimate the prevalence of anemia and determine its associated factors among lactating women in Sierra Leone.Methods:The 2019 Sierra Leone Demographic and Health Survey (SLDH) data were used of which 1543 lactating women aged 15 to 49 years old had hemoglobin measurements. Multistage stratified sampling was used to select study participants and data were collected using validated questionnaires. Multivariate binary logistic regression was used to determine factors associated with anemia among lactating women in Sierra Leone.Results:The general prevalence of anemia among lactating women in Sierra Leone was 52.9% (95% CI = 50.9-55.8). Almost a quarter, 23.8% (95% CI = 22.1-26.3) of the lactating women had mild anemia, 27.4% (95% CI = 25.3-29.7) had moderate anemia and 1.7% (95% CI = 1.1-2.5) had severe anemia. The use of modern contraceptives (aOR = 1.64, 95% CI = 1.09-2.47), not being visited by a field worker in the past year (aOR = 1.51, 95% CI = 1.12-2.03) and being Muslim (aOR = 1.46, 95% CI = 1.11-1.91), were associated with higher odds of being anemic. Being given and having bought iron supplements during pregnancy (aOR = 0.46, 95% CI = 0.25-0.87) was associated with less odds of being anemic.Conclusion:More than half of the lactating mothers in our study were anemic. The risk factors for anemia in our study included: use of modern contraceptives, not being visited by a field worker in the past year and being Muslim. Receiving iron supplements during pregnancy was protective against anemia. According to the results from this study, the recommendation for lactating women was to maintain routine interface with the healthcare system which includes being visited by a field worker who should prescribe and issue iron supplements to them. Lactating women especially Muslims should receive routine nutrition education by the health workers at the health facilities during antenatal care visits or postnatal care in regard to anemia and means of prevention and treatment. Community stakeholders should also work in collaboration to establish scalable methods to correctly identify pregnant women with risk factors, inform them about anemia with caution, and apply appropriate measures as trained or instructed
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-17T06:02:45Z
      DOI: 10.1177/11786388221105732
      Issue No: Vol. 15 (2022)
  • Evenness of Dietary Protein Intake Is Positively Associated with Lean Mass
           and Strength in Healthy Women

    • Authors: Nathaniel R Johnson, Christopher J Kotarsky, Sean J Mahoney, Bailee C Sawyer, Kara A Stone, Wonwoo Byun, Kyle J Hackney, Steven Mitchell, Sherri N Stastny
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Evenness of protein intake is associated with increased lean mass, but its relationship with muscle strength and performance is uncertain.Objectives:We determined the association of evenness of protein intake with lean mass, muscle strength and endurance, and functional ability.Design:This was a cross-sectional study.Setting:Data were collected at a research university in the upper midwestern United States.Participants:One hundred ninety-two healthy women, aged 18 to 79 years, mean ± SEM 41.9 ± 1.3, completed the study.Measurements:Dietary intake was assessed using 3-day food diaries verified with food frequency questionnaires. To assess evenness of protein intake, the day was divided into 3 periods: waking to 11:30, 11:31 to 16:30, and after 16:30. Lean mass was measured with dual energy X-ray absorptiometry. Lower-body muscle strength and endurance were determined using isokinetic dynamometry. Upper-body muscle strength was maximal handgrip strength. Functional ability was assessed using 6-m gait speed and 30-second chair stand tests. Accelerometry measured physical activity.Results:Intakes of 25 g or more of protein at 1 or more of the 3 periods was positively associated with lean mass (β ± S.E.; 1.067 ± 0.273 kg, P 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-06-17T06:00:25Z
      DOI: 10.1177/11786388221101829
      Issue No: Vol. 15 (2022)
  • Examining the Benefits of Digitally Selectable Meals Called “À La Carte
           Digital-Select” in Cancer Chemotherapy Patients

    • Authors: Takashi Aoyama
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      We explored the benefits of a digitized bedside terminal with a touchscreen for selectable hospital meals called “à la carte digital-select” in cancer chemotherapy patients. The subjects used “à la carte digital-select” for 35 days, from November to December 2015. On average, 253 (between 196 and 288) patients accessed this system per day, and 40 patients used it daily (15.9%). Subjects included 75 patients (cancer chemotherapy: chem-digital-select patients, female: 47) and 12 patients (concurrent chemo radiotherapy: CRT-digital-select patients, female: 6) with a repeat rate of 87% (65) and 100% (12). The average length of hospital stay in chem-digital-select patients was 6 days (1-35), the average number of days using “à la carte digital-select” was 3 days (1-24); a correlation was observed between these factors (r = .80; P 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-05-17T07:00:56Z
      DOI: 10.1177/11786388221098507
      Issue No: Vol. 15 (2022)
  • Nutritional Status of Postpartum Mothers and Associated Risk Factors in
           Shey-Bench District, Bench-Sheko Zone, Southwest Ethiopia: A Community
           Based Cross-Sectional Study

    • Authors: Asresash Sebeta, Abel Girma, Rediet Kidane, Eyob Tekalign, Dessalegn Tamiru
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Malnutrition affects millions of people in developing countries and contributes to poor health outcomes and nutritional status among women in the postpartum period. Lactation increases high nutritional demands and marks a significant life transition that can impact diet quality and subsequently predispose woman to high risk of overweight and undernutrition. Although, studies have been conducted on the nutritional status of lactating women, there is a gap especially on women’s nutritional status during the postpartum period. Therefore, this study aimed to assess the nutritional status of postpartum women and associated factors in Shey-Bench District, Bench-Sheko Zone, Southwest Ethiopia, 2020.Method:A community-based cross-sectional study was conducted in Shey-Bench District from March 1 to 30/2020 among 359 postpartum mothers. Bivariate analysis was employed to select candidate variables at P-value
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-04-25T06:20:31Z
      DOI: 10.1177/11786388221088243
      Issue No: Vol. 15 (2022)
  • Lifestyle Modification Practice and Associated Factors Among Diagnosed
           Hypertensive Patients in Selected Hospitals in Central Gondar Zone

    • Authors: Moges Smachew, Melkitu Fentie Melak, Azeb Atenafu, Aysheshim Kassahun Belew
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Hypertension is one of the leading causes of disability and death in both developed and developing countries including Ethiopia. Non-communicable diseases account for 42% of deaths in Ethiopia. However, it is still widely undetected and poorly controlled. Hence, this study aims to assess the lifestyle modification practices and related factors of adult hypertensive patients in the central Gondar region of northwestern Ethiopia.Methods:Institutional based, cross-sectional study was conducted from April 10 up to May 10, 2021. A simple random sampling was used to select 629 study participants. Data were collected by using self-administered and structured questionnaire. Data were entered to EpiData 4.6 and exported to SPSS 20 for further analysis. A multivariable logistic regression analysis was employed to identify the factors associated with lifestyle modification. Adjusted Odds Ratio (AOR) with 95% confidence interval was used to show the strength of association, while a P-value
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-03-23T01:25:31Z
      DOI: 10.1177/11786388221088245
      Issue No: Vol. 15 (2022)
  • Myriocin Treatment Reverses Alcohol-Induced Alterations in Polyunsaturated
           Fatty Acid-Containing Phospholipid Expression in the Liver

    • Authors: Emine B Yalcin, Ming Tong, Camilla Homans, Suzanne M de la Monte
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Chronic heavy alcohol exposure causes steatohepatitis manifested by abnormal intra-hepatocyte accumulation of lipid and parenchymal inflammation. Attendant alterations in polyunsaturated fatty acid (PUFA)-containing phospholipids could cause alcoholic liver disease (ALD) to progress by promoting oxidative stress, inflammation, and fibrogenesis. Previously we showed that myriocin, a serine palmitoyltransferase inhibitor, ameliorates experimental alcohol-induced steatohepatitis. However, the surprising overall therapeutic responses suggested that myriocin’s targets may go beyond sphingolipids. To this end, the present study examines the effects of myriocin on hepatic composition of docosahexaenoic acid (DHA)- and arachidonic acid (AA)-containing phospholipids in an experimental model of ALD. A chronic+binge ethanol exposure model was generated by feeding Long Evans rats with ethanol-containing diets (24% caloric content) for 8 weeks and simultaneously binge gavage administering 2 g/kg ethanol on Tuesdays, Thursdays and Saturdays during Weeks 6-8. Myriocin was administered by i.p. injection on Mondays, Wednesdays, and Fridays of Weeks 3-8. Control rats were studied in parallel. Upon euthanasia, the livers were harvested to examine ethanol- and/or myriocin-modulation of hepatic lipids using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS). Results were analyzed statistically by two-way analysis of variance and depicted with data bar plots and heatmaps. Chronic+binge ethanol exposures significantly increased hepatic expression of AA-containing phospholipids including PE(36:4) (P = .005), PE(38:4) (P = .03), and PI(38:4) (P = .04) and reduced DHA-containing phospholipids including PS(40:6) (P = .03) and PE(40:6) (P = .04) relative to control. Myriocin partially reversed ethanol’s effects on hepatic PUFA expression by decreasing PE(36:4) (P = .004) and increasing PS(40:6) (P = .04) and PI(40:6) (P = .0003) relative to ethanol-exposed rats. Ethanol-mediated alterations in hepatic PUFA-containing phospholipids may contribute to hepatic oxidative and inflammatory injury by increasing AA and fibrogenesis by inhibiting DHA. The results suggest that Myriocin may help reduce or prevent long-term and progressive liver injury stemming from excessive chronic+binge ethanol consumption.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-02-28T09:39:24Z
      DOI: 10.1177/11786388221082012
      Issue No: Vol. 15 (2022)
  • Polyunsaturated Fatty Acid Composition in Breast Milk Plasma of
           HIV-infected and Uninfected Mothers in Relation to Infant Clinical

    • Authors: Lucy Mabaya, Hilda Tendisa Matarira, Donald Moshen Tanyanyiwa, Cuthbert Musarurwa, Johannes Mukwembi, Taona Emmah Mudluli, Tatenda Marera
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:The increased coverage of prevention of mother to child transmission (PMTCT) services has significantly reduced paediatric HIV infection incidence. The aim of the study was to compare breast milk omega-6 and omega-3 polyunsaturated fatty acid profiles of HIV infected and uninfected mothers and determine the association between fatty acid profiles and postnatal transmission of HIV, morbidity/mortality of HIV exposed and unexposed infants.Methods:A prospective cohort study of 57 HIV infected and 57 HIV uninfected lactating mothers was conducted in Gweru, Zimbabwe from July 2019 to March 2020. The women’s 114 babies (term and preterm) were also enrolled and stratified by HIV exposure and infection status. The mother-infant pairs were followed up at 6 weeks, 16 weeks and 6 months postpartum to determine, HIV transmission rate, breast milk polyunsaturated fatty acid profiles as well as infant clinical outcomes.Results:The mean breast milk docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels in HIV uninfected mothers (0.82 ± 0.92; 0.47 ± 0.75 μg/ml respectively) at 6 weeks postpartum were significantly higher compared to those of HIV infected mothers (0.33 ± 0.32; 0.08 ± 0.14 μg/ml) respectively. The same pattern was observed at 16 weeks postpartum in terms of DHA and EPA mean concentration. However, the arachidonic acid (AA) levels and AA/DHA ratio measured at 6 weeks postpartum were significantly higher in HIV infected mothers (2.31 ± 2.01; 17.18 ± 52.47 respectively) compared to HIV uninfected mothers (0.82 ± 0.54; 9.71 ± 21.80; P 
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-02-08T05:14:27Z
      DOI: 10.1177/11786388211072768
      Issue No: Vol. 15 (2022)
  • Sugar-Free Dark Chocolate Consumption Results in Lower Blood Glucose in
           Adults With Diabetes

    • Authors: Barbara Oliveira, Kaja Falkenhain, Jonathan P Little
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Diabetes is characterized by an impaired ability to appropriately control blood glucose. Postprandial hyperglycemia, in particular, is associated with complications in people with type 1 diabetes (T1D) and type 2 diabetes (T2D). The objective of this study was to determine how sugar-free dark chocolate sweetened with stevia, erythritol, and inulin impacts postprandial blood glucose levels in individuals with diabetes compared to conventional dark chocolate. In a randomized crossover design, 13 participants consumed 1 bar (34 g) of sugar-free dark chocolate or 1 bar (34 g) of conventional dark chocolate with glucose levels measured before and throughout a 120-min postprandial period. The incremental area under the curve (iAUC) was lower after the consumption of sugar-free dark chocolate (−65%, P = .04) compared to conventional dark chocolate. No significant differences between chocolates were found for peak glucose value above baseline, the total area under the curve, or peak glucose values. Our results suggest that a sugar-free dark chocolate bar sweetened with stevia, erythritol and inulin led to a lower blood glucose iAUC compared to the conventional dark chocolate bar in people with diabetes, whilst longer-term effects on glucose control remain to be determined.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-02-07T09:11:25Z
      DOI: 10.1177/11786388221076962
      Issue No: Vol. 15 (2022)
  • Determinants of Early Initiation of Breastfeeding in West Belessa
           District, Northwest Ethiopia

    • Authors: Desalew Degu Ayalew, Belayneh Ayanaw Kassie, Melkamu Tamir Hunegnaw, Kassahun Alemu Gelaye, Aysheshim Kassahun Belew
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:The world is now suffering from malnutrition and remains one of the leading causes of death for under 5 children. Children from developing countries, including Ethiopia also suffer from undernutrition due to suboptimal breastfeeding practice. Therefore, the aim of this study was to assess the EIBF practices and determinants among children aged less than 24 months in West Belessa district, Northwest Ethiopia, 2019.Methods:A community-based cross-sectional study was conducted from January 2 to February 28, 2019 in the West Belessa district. A total of 569 mother-children pairs were participated in the study. Study particnapants were selected by using simple random sampling technique. The data were collected by an interviewer-administered structured questionnaire. Data were entered and analyzed by using Epi-Info version 7 and SPPS version 20, respectively. Bi-variable and Multivariable logistic regression analysis were done. Odds ratio with 95% confidence was done to determine the level of significance value less than .05 considered as significant with the outcome variable.Result:The prevalence of early initiation of breastfeeding (EIBF) was found to be 77.7 % (95%CI, 74.3-81.0). Age of the mother (AOR = 2.76, 95%CI [1.21, 6.27]), antenatal care (ANC) (AOR = 3.79, 95%CI [2.58, 9.94]), and number of antenatal care visit (AOR = 1.85, 95%CI [1.03, 3.85]) were significantly associated with early initiation of breastfeeding.Conclusion and Recommendation:In this study, more than three fourth of children were received early initiation of breastfeeding within 1 hour after delivery. Age of the mother, antenatal, and number of antenatal care were associated with EIBF. Therefore, during this contact period, improve antenatal services by increasing accessibility and providing counseling is important to improve EIBF utilization.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-01-08T09:38:52Z
      DOI: 10.1177/11786388211065221
      Issue No: Vol. 15 (2022)
  • Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients,
           Preliminary Data

    • Authors: Maurizio Dattilo, Carolina Fontanarosa, Michele Spinelli, Vittorio Bini, Angela Amoresano
      Abstract: Nutrition and Metabolic Insights, Volume 15, Issue , January-December 2022.
      Background:Hydrogen sulfide (H2S) is a pivotal gasotransmitter networking with nitric oxide (NO) and carbon monoxide (CO) to regulate basic homeostatic functions. It is released by the alternative pathways of transulfuration by the enzymes Cystathionine Beta Synthase (CBS) and Cystathionine Gamma Lyase (CSE), and by Cysteine AminoTransferase (CAT)/ 3-Mercaptopyruvate Sulfur Transferase (3MPST). A non-enzymatic, intravascular release is also in place. We retrospectively investigated the possibility to modulate the endogenous H2S release and signaling in humans by a dietary manipulation with supplemented micronutrients (L-cystine, Taurine and pyridoxal 5-phopsphate/P5P).Methods:Patients referring for antiaging purposes underwent a 10-day supplementation. Blood was collected at baseline and after treatment and the metabolome was investigated by mass spectrometry to monitor the changes in the metabolites reporting on H2S metabolism and related pathways.Results:Data were available from 6 middle aged subjects (2 women). Micronutrients increased 3-mercaptopyruvate (P = .03), reporting on the activity of CAT that provides the substrate for H2S release within mitochondria by 3MPST, decreased lanthionine (P = .024), reporting the release of H2S from CBS, and had no significant effect of H2S release from CSE. This is compatible with a homeostatic balancing. We also recorded a strong increase of reporters of H2S-induced pathways including 5-MethylTHF (P = .001) and SAME (P = .022), reporting on methylation capacity, and of BH4 (P = .021) and BH2 (P = .028) reporting on nitric oxide metabolism. These activations may be explained by the concomitant induction of non-enzymatic release of H2S.Conclusions:Although the current evidences are weak and will need to be confirmed, the effect of micronutrients was compatible with an increase of the H2S endogenous release and signaling within the control of homeostatic mechanisms, further endorsing the role of feeding in health and disease. These effects might result in a H2S boosting effect in case of defective activity of pathologic origin, which should be checked in duly designed clinical trials.
      Citation: Nutrition and Metabolic Insights
      PubDate: 2022-01-07T10:24:55Z
      DOI: 10.1177/11786388211065372
      Issue No: Vol. 15 (2022)
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