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  Subjects -> NUTRITION AND DIETETICS (Total: 201 journals)
Showing 1 - 64 of 64 Journals sorted alphabetically
Acta Portuguesa de Nutrição     Open Access   (Followers: 2)
Advances in Digestive Medicine     Open Access   (Followers: 12)
Advances in Eating Disorders : Theory, Research and Practice     Hybrid Journal   (Followers: 22)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 63)
Advances in Nutrition     Hybrid Journal   (Followers: 56)
African Journal of Biomedical Research     Open Access  
African Journal of Food, Agriculture, Nutrition and Development     Open Access   (Followers: 17)
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 3)
American Journal of Botany     Full-text available via subscription   (Followers: 19)
American Journal of Clinical Nutrition     Hybrid Journal   (Followers: 178)
American Journal of Food and Nutrition     Open Access   (Followers: 49)
American Journal of Food Technology     Open Access   (Followers: 9)
Amerta Nutrition     Open Access   (Followers: 1)
Amino Acids     Hybrid Journal   (Followers: 8)
Annals of Nutrition and Metabolism     Full-text available via subscription   (Followers: 52)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Annual Review of Nutrition     Full-text available via subscription   (Followers: 40)
Appetite     Hybrid Journal   (Followers: 25)
Arab Journal of Nutrition and Exercise     Open Access  
Archive of Food and Nutritional Science     Open Access   (Followers: 1)
Archivos Latinoamericanos de Nutrición     Open Access  
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asian Journal of Clinical Nutrition     Open Access   (Followers: 12)
Bangladesh Journal of Nutrition     Open Access   (Followers: 5)
Bioactive Carbohydrates and Dietary Fibre     Hybrid Journal   (Followers: 2)
BMC Nutrition     Open Access   (Followers: 13)
BMJ Nutrition, Prevention & Health     Open Access   (Followers: 13)
British Journal Of Nutrition     Hybrid Journal   (Followers: 96)
Cahiers de Nutrition et de Diététique     Full-text available via subscription   (Followers: 1)
Canadian Food Studies / La Revue canadienne des études sur l'alimentation     Open Access   (Followers: 1)
Canadian Journal of Dietetic Practice and Research     Full-text available via subscription   (Followers: 17)
Case Reports in Clinical Nutrition     Open Access   (Followers: 1)
Childhood Obesity     Hybrid Journal   (Followers: 24)
Clinical Nutrition     Hybrid Journal   (Followers: 94)
Clinical Nutrition ESPEN     Hybrid Journal   (Followers: 23)
Clinical Nutrition Experimental     Open Access   (Followers: 1)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Nutrition Open Science     Open Access  
Clinical Obesity     Hybrid Journal   (Followers: 18)
Comparative Exercise Physiology     Hybrid Journal   (Followers: 21)
Current Developments in Nutrition     Open Access   (Followers: 6)
Current Nutrition & Food Science     Hybrid Journal   (Followers: 25)
Current Nutrition Reports     Hybrid Journal   (Followers: 8)
Current Opinion in Clinical Nutrition & Metabolic Care     Hybrid Journal   (Followers: 26)
Current Research in Nutrition and Food Science     Open Access   (Followers: 7)
DEMETRA : Alimentação, Nutrição & Saúde     Open Access  
Diabetes, Metabolic Syndrome and Obesity     Open Access   (Followers: 48)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 25)
Ecology of Food and Nutrition     Hybrid Journal   (Followers: 10)
Egyptian Journal of Nutrition and Health     Open Access   (Followers: 1)
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrinología, Diabetes y Nutrición     Full-text available via subscription   (Followers: 1)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Ernährung & Medizin     Hybrid Journal   (Followers: 3)
European Journal of Clinical Nutrition     Hybrid Journal   (Followers: 75)
European Journal of Nutrition     Hybrid Journal   (Followers: 36)
European Journal of Nutrition & Food Safety     Open Access   (Followers: 2)
Food & Nutrition Research     Open Access   (Followers: 35)
Food and Environmental Virology     Hybrid Journal   (Followers: 1)
Food and Foodways: Explorations in the History and Culture of     Hybrid Journal   (Followers: 12)
Food and Health     Open Access   (Followers: 1)
Food and Nutrition Bulletin     Hybrid Journal   (Followers: 6)
Food and Waterborne Parasitology     Open Access  
Food Digestion     Hybrid Journal   (Followers: 5)
Food Frontiers     Open Access   (Followers: 1)
Food Hydrocolloids for Health     Open Access  
Food Quality and Safety     Open Access   (Followers: 2)
Food Science & Nutrition     Open Access   (Followers: 59)
Food, Culture and Society: An International Journal of Multidisciplinary Research     Full-text available via subscription   (Followers: 13)
Frontiers in Nutrition     Open Access   (Followers: 11)
Frontiers in Sustainable Food Systems     Open Access   (Followers: 3)
Functional Foods in Health and Disease     Open Access  
Gazi Sağlık Bilimleri Dergisi     Open Access  
Genes & Nutrition     Open Access   (Followers: 5)
Hacettepe University Faculty of Health Sciences Journal     Open Access  
Human Nutrition & Metabolism     Open Access   (Followers: 1)
Indian Journal of Nutrition and Dietetics     Hybrid Journal   (Followers: 1)
Indonesian Food and Nutrition Progress     Open Access  
International Journal for Vitamin and Nutrition Research     Hybrid Journal   (Followers: 10)
International Journal of Behavioral Nutrition and Physical Activity     Open Access   (Followers: 31)
International Journal of Child Health and Nutrition     Hybrid Journal   (Followers: 6)
International Journal of Eating Disorders     Hybrid Journal   (Followers: 23)
International Journal of Food Safety, Nutrition and Public Health     Hybrid Journal   (Followers: 20)
International Journal of Food Science and Nutrition Engineering     Open Access   (Followers: 7)
International Journal of Food Sciences and Nutrition     Hybrid Journal   (Followers: 11)
International Journal of Gastroenterology, Hepatology, Transplant and Nutrition     Open Access   (Followers: 2)
International Journal of Nutrition and Metabolism     Open Access   (Followers: 23)
International Journal of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
International Journal of Obesity     Hybrid Journal   (Followers: 93)
International Journal of Sport Nutrition & Exercise Metabolism     Hybrid Journal   (Followers: 88)
Journal of Advanced Nutrition and Human Metabolism     Open Access   (Followers: 16)
Journal of Agriculture, Food Systems, and Community Development     Open Access   (Followers: 3)
Journal of Dietary Supplements     Hybrid Journal   (Followers: 10)
Journal of Eating Disorders     Open Access   (Followers: 15)
Journal of Ethnic Foods     Open Access   (Followers: 1)
Journal of Food & Nutritional Disorders     Hybrid Journal   (Followers: 2)
Journal of Food and Nutrition Research     Open Access   (Followers: 10)
Journal of Food Chemistry and Nutrition     Open Access   (Followers: 6)
Journal of Food Science and Nutrition Therapy     Open Access   (Followers: 1)
Journal of Health, Population and Nutrition     Open Access   (Followers: 13)
Journal of Human Nutrition and Dietetics     Hybrid Journal   (Followers: 52)
Journal of Hunger & Environmental Nutrition     Hybrid Journal   (Followers: 7)
Journal of Medical Nutrition and Nutraceuticals     Open Access   (Followers: 4)
Journal of Medicinal Herbs and Ethnomedicine     Open Access  
Journal of Muscle Foods     Hybrid Journal  
Journal of Nutraceuticals and Herbal Medicine     Open Access  
Journal of Nutrition     Hybrid Journal   (Followers: 42)
Journal of Nutrition & Intermediary Metabolism     Open Access  
Journal of Nutrition and Metabolism     Open Access   (Followers: 16)
Journal of Nutrition Education and Behavior     Hybrid Journal   (Followers: 19)
Journal of Nutrition in Gerontology and Geriatrics     Hybrid Journal   (Followers: 15)
Journal of Nutrition, Health and Aging     Hybrid Journal   (Followers: 30)
Journal of Nutritional & Environmental Medicine     Full-text available via subscription   (Followers: 2)
Journal of Nutritional Biochemistry     Hybrid Journal   (Followers: 8)
Journal of Nutritional Disorders & Therapy     Open Access  
Journal of Nutritional Ecology and Food Research     Full-text available via subscription  
Journal of Nutritional Science     Open Access   (Followers: 2)
Journal of Obesity     Open Access   (Followers: 24)
Journal of Parenteral and Enteral Nutrition     Hybrid Journal   (Followers: 35)
Journal of Pediatric Gastroenterology and Nutrition (JPGN)     Hybrid Journal   (Followers: 52)
Journal of Pharmacy and Nutrition Sciences     Open Access   (Followers: 5)
Journal of Renal Nutrition     Hybrid Journal   (Followers: 28)
Journal of Renal Nutrition and Metabolism     Open Access   (Followers: 2)
Journal of Sensory Studies     Hybrid Journal  
Journal of Spices and Aromatic Crops     Open Access   (Followers: 2)
Journal of the Academy of Nutrition and Dietetics     Full-text available via subscription   (Followers: 61)
Journal of the American College of Nutrition     Hybrid Journal   (Followers: 7)
Journal of the Australasian College of Nutritional and Environmental Medicine     Full-text available via subscription  
Jurnal Gizi dan Dietetik Indonesia : Indonesian Journal of Nutrition and Dietetics     Open Access   (Followers: 1)
Jurnal Gizi Indonesia / The Indonesian Journal of Nutrition     Open Access  
Jurnal Gizi Klinik Indonesia     Open Access  
Jurnal Penelitian Gizi dan Makanan     Open Access   (Followers: 1)
Jurnal Riset Kesehatan     Open Access  
La Ciencia al Servicio de la Salud y Nutrición     Open Access  
Lifestyle Genomics     Open Access   (Followers: 2)
Lifestyle Journal     Open Access  
Maternal & Child Nutrition     Hybrid Journal   (Followers: 14)
Médecine & Nutrition     Full-text available via subscription  
Media Gizi Indonesia     Open Access  
Metabolism and Nutrition in Oncology     Open Access   (Followers: 4)
Molecular Nutrition & Food Research     Hybrid Journal   (Followers: 6)
NFS Journal     Open Access  
Nigerian Food Journal     Full-text available via subscription   (Followers: 2)
Nigerian Journal of Nutritional Sciences     Full-text available via subscription  
npj Science of Food     Open Access  
Nutrición Hospitalaria     Open Access   (Followers: 3)
Nutrients     Open Access   (Followers: 13)
Nutrire     Hybrid Journal  
Nutrition     Hybrid Journal   (Followers: 22)
Nutrition & Dietetics     Hybrid Journal   (Followers: 32)
Nutrition & Food Science     Hybrid Journal   (Followers: 9)
Nutrition & Diabetes     Open Access   (Followers: 20)
Nutrition & Metabolism     Open Access   (Followers: 17)
Nutrition - Science en évolution     Full-text available via subscription   (Followers: 5)
Nutrition and Cancer     Hybrid Journal   (Followers: 13)
Nutrition and Dietary Supplements     Open Access   (Followers: 15)
Nutrition and Health     Hybrid Journal   (Followers: 8)
Nutrition and Metabolic Insights     Open Access   (Followers: 4)
Nutrition Bulletin     Hybrid Journal   (Followers: 11)
Nutrition Bytes     Open Access   (Followers: 5)
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 45)
Nutrition Journal     Open Access   (Followers: 12)
Nutrition Research     Hybrid Journal   (Followers: 23)
Nutrition Research Reviews     Hybrid Journal   (Followers: 13)
Nutrition Reviews     Hybrid Journal   (Followers: 38)
Nutrition Today     Hybrid Journal   (Followers: 14)
Nutrition, Metabolism and Cardiovascular Diseases     Hybrid Journal   (Followers: 13)
Nutritional Neuroscience : An International Journal on Nutrition, Diet and Nervous System     Hybrid Journal   (Followers: 9)
Obesity     Hybrid Journal   (Followers: 58)
Obesity Facts     Open Access   (Followers: 9)
Obesity Reviews     Hybrid Journal   (Followers: 25)
Oil Crop Science     Open Access   (Followers: 2)
Open Food Science Journal     Open Access  
Open Nutrition Journal     Open Access   (Followers: 2)
Open Obesity Journal     Open Access   (Followers: 1)
Pakistan Journal of Nutrition     Open Access   (Followers: 2)
Pediatric Obesity     Hybrid Journal   (Followers: 9)
Perspectivas en Nutrición Humana     Open Access   (Followers: 2)
PharmaNutrition     Hybrid Journal   (Followers: 3)
Plant Foods for Human Nutrition     Hybrid Journal   (Followers: 5)
Plant Production Science     Open Access   (Followers: 1)
Proceedings of the Nutrition Society     Hybrid Journal   (Followers: 8)
Progress in Nutrition     Open Access   (Followers: 2)
Public Health Nutrition     Hybrid Journal   (Followers: 30)
RBNE - Revista Brasileira de Nutrição Esportiva     Open Access   (Followers: 1)
RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento     Open Access   (Followers: 1)
Revista Chilena de Nutricion     Open Access   (Followers: 2)
Revista Española de Nutrición Humana y Dietética     Open Access   (Followers: 3)
Revista Mexicana de Trastornos Alimentarios     Open Access   (Followers: 1)
Revista Salud Pública y Nutrición     Open Access  
Segurança Alimentar e Nutricional     Open Access  
South African Journal of Clinical Nutrition     Open Access   (Followers: 5)
The Australian Coeliac     Full-text available via subscription   (Followers: 1)
Topics in Clinical Nutrition     Hybrid Journal   (Followers: 20)
UNICIÊNCIAS     Open Access  
Universal Journal of Food and Nutrition Science     Open Access   (Followers: 4)
World Food Policy     Hybrid Journal   (Followers: 3)

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Similar Journals
Journal Cover
Nutrition Research Reviews
Journal Prestige (SJR): 1.756
Citation Impact (citeScore): 5
Number of Followers: 13  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0954-4224 - ISSN (Online) 1475-2700
Published by Cambridge University Press Homepage  [352 journals]
  • NRR volume 35 issue 2 Front matter

    • Free pre-print version: Loading...

      Pages: 1 - 1
      PubDate: 2022-11-08
      DOI: 10.1017/S0954422422000191
       
  • Circulating bile acids as a link between the gut microbiota and
           cardiovascular health: impact of prebiotics, probiotics and
           polyphenol-rich foods

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      Authors: Pushpass; Rose-Anna G., Alzoufairi, Shouq, Jackson, Kim G., Lovegrove, Julie A.
      Pages: 161 - 180
      Abstract: Beneficial effects of probiotic, prebiotic and polyphenol-rich interventions on fasting lipid profiles have been reported, with changes in the gut microbiota composition believed to play an important role in lipid regulation. Primary bile acids, which are involved in the digestion of fats and cholesterol metabolism, can be converted by the gut microbiota to secondary bile acids, some species of which are less well reabsorbed and consequently may be excreted in the stool. This can lead to increased hepatic bile acid neo-synthesis, resulting in a net loss of circulating low-density lipoprotein. Bile acids may therefore provide a link between the gut microbiota and cardiovascular health. This narrative review presents an overview of bile acid metabolism and the role of probiotics, prebiotics and polyphenol-rich foods in modulating circulating cardiovascular disease (CVD) risk markers and bile acids. Although findings from human studies are inconsistent, there is growing evidence for associations between these dietary components and improved lipid CVD risk markers, attributed to modulation of the gut microbiota and bile acid metabolism. These include increased bile acid neo-synthesis, due to bile sequestering action, bile salt metabolising activity and effects of short-chain fatty acids generated through bacterial fermentation of fibres. Animal studies have demonstrated effects on the FXR/FGF-15 axis and hepatic genes involved in bile acid synthesis (CYP7A1) and cholesterol synthesis (SREBP and HMGR). Further human studies are needed to determine the relationship between diet and bile acid metabolism and whether circulating bile acids can be utilised as a potential CVD risk biomarker.
      PubDate: 2021-04-30
      DOI: 10.1017/S0954422421000081
       
  • Nutrition across the curriculum: a scoping review exploring the
           integration of nutrition education within primary schools

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      Authors: Follong; Berit M., Verdonschot, Angeliek, Prieto-Rodriguez, Elena, Miller, Andrew, Collins, Clare E., Bucher, Tamara
      Pages: 181 - 196
      Abstract: Primary schools contribute to promoting healthy eating behaviour and preventing overweight and obesity by providing nutrition education. Research highlights the importance of improving teachers’ programme implementation to enhance intervention effectiveness. An integrative approach has been suggested to reduce time barriers that teachers currently experience in teaching nutrition. This scoping review explores use and effectiveness of integrative teaching in primary-school-based nutrition education programmes. Six databases were searched for primary-school-based interventions on nutrition education. Papers reporting on integration of nutrition topics within core curriculum were included. s and full texts of potentially relevant articles were screened to determine eligibility. Next, data were extracted and tabulated. Findings were collated and summarised to describe intervention characteristics, subject integration and effectiveness of the included programmes. Data describing integration of nutrition into the primary school curriculum were extracted from 39 eligible papers. Nutrition education programmes often involve lessons about food groups and are frequently embedded within the mathematics, science or literacy syllabus. Although articles report on the integration of nutrition, the use of this approach was not commonly described in detail. Only seven papers discussed student outcomes related to the integration of nutrition education within core subjects. The ability to draw strong conclusions about school-based nutrition intervention effectiveness is limited by the current lack of programme description and methodological issues. Hence, more research is warranted to inform evidence on effectiveness of integrative nutrition education for both teacher and student outcomes. Future studies that include greater detail regarding the integrative approach are needed.
      PubDate: 2021-04-30
      DOI: 10.1017/S0954422421000111
       
  • Understanding the role of smoking and chronic excess alcohol consumption
           on reduced caloric intake and the development of sarcopenia

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      Authors: Prokopidis; Konstantinos, Witard, Oliver C.
      Pages: 197 - 206
      Abstract: This narrative review provides mechanistic insight into the biological link between smoking and/or chronic excess alcohol consumption, and increased risk of developing sarcopenia. Although the combination of excessive alcohol consumption and smoking is often associated with ectopic adipose deposition, this review is focused on the context of a reduced caloric intake (leading to energy deficit) that also may ensue due to either lifestyle habit. Smoking is a primary cause of periodontitis and chronic obstructive pulmonary disease that both induce swallowing difficulties, inhibit taste and mastication, and are associated with increased risk of muscle atrophy and mitochondrial dysfunction. Smoking may contribute to physical inactivity, energy deficit via reduced caloric intake, and increased systemic inflammation, all of which are factors known to suppress muscle protein synthesis rates. Moreover, chronic excess alcohol consumption may result in gut microbiota dysbiosis and autophagy-induced hyperammonemia, initiating the up-regulation of muscle protein breakdown and down-regulation of muscle protein synthesis via activation of myostatin, AMPK and REDD1, and deactivation of IGF-1. Future research is warranted to explore the link between oral healthcare management and personalised nutrition counselling in light of potential detrimental consequences of chronic smoking on musculoskeletal health outcomes in older adults. Experimental studies should investigate the impact of smoking and chronic excess alcohol consumption on the gut–brain axis, and explore biomarkers of smoking-induced oral disease progression. The implementation of behavioural change interventions and health policies regarding smoking and alcohol intake habits may mitigate the clinical and financial burden of sarcopenia on the healthcare system.
      PubDate: 2021-05-24
      DOI: 10.1017/S0954422421000135
       
  • The gut microbiota as a therapeutic target for obesity: a scoping review

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      Authors: Santos-Paulo; Stephanie, Costello, Samuel P., Forster, Samuel C., Travis, Simon P., Bryant, Robert V.
      Pages: 207 - 220
      Abstract: There is mounting evidence that microbiome composition is intimately and dynamically connected with host energy balance and metabolism. The gut microbiome is emerging as a novel target for counteracting the chronically positive energy balance in obesity, a disease of pandemic scale which contributes to>70 % of premature deaths. This scoping review explores the potential for therapeutic modulation of gut microbiota as a means of prevention and/or treatment of obesity and obesity-associated metabolic disorders. The evidence base for interventional approaches which have been shown to affect the composition and function of the intestinal microbiome is summarised, including dietary strategies, oral probiotic treatment, faecal microbiota transplantation and bariatric surgery. Evidence in this field is still largely derived from preclinical rodent models, but interventional studies in obese populations have demonstrated metabolic improvements effected by microbiome-modulating treatments such as faecal microbiota transplantation, as well as drawing attention to the unappreciated role of microbiome modulation in well-established anti-obesity interventions, such as dietary change or bariatric surgery. The complex relationship between microbiome composition and host metabolism will take time to unravel, but microbiome modulation is likely to provide a novel strategy in the limited armamentarium of effective treatments for obesity.
      PubDate: 2021-06-08
      DOI: 10.1017/S0954422421000160
       
  • Impact of Christian Orthodox Church dietary recommendations on metabolic
           syndrome risk factors: a scoping review

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      Authors: Kokkinopoulou; A., Kafatos, A.
      Pages: 221 - 235
      Abstract: Fasting has been a practice among followers of different religions for many years. Christian Orthodox Church (COC) fasting is a periodic vegetarian-type diet in which seafood and snails are allowed on most fasting days. The present scoping review aimed to present available data regarding the benefits of COC fasting on metabolic syndrome (MetS) risk factors. Databases were searched for available studies. Twenty publications, with a total of 1226 fasting participants, provided data on the effects on different variables of MetS, including blood pressure, blood lipids and anthropometric measurements. Fasters’ diet is characterised by low saturated and trans fat intake, high complex carbohydrate and fibre consumption, due to permissible foods. COC fasting has no deficiency in essential amino acid intake since seafood and snails are allowed on fasting days. Fasters have healthier blood lipid profiles during and after COC fasting periods, and total cholesterol, LDL-cholesterol, systolic blood pressure, body weight and BMI are reduced after a fasting period. Due to restricted or forbidden intake of specific foods during the COC fasting periods, one might expect that fasters have reduced intake of macro- and micronutrients, but as shown in the available literature, there are no deficiencies. Future research on COC fasting is needed in areas not investigated at all, like MetS, before reaching definite conclusions.
      PubDate: 2021-06-10
      DOI: 10.1017/S0954422421000184
       
  • Obesity and dietary fat influence dopamine neurotransmission: exploring
           the convergence of metabolic state, physiological stress, and inflammation
           on dopaminergic control of food intake

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      Authors: Wallace; Conner W., Fordahl, Steve C.
      Pages: 236 - 251
      Abstract: The aim of this review is to explore how metabolic changes induced by diets high in saturated fat (HFD) affect nucleus accumbens (NAc) dopamine neurotransmission and food intake, and to explore how stress and inflammation influence this process. Recent evidence linked diet-induced obesity and HFD with reduced dopamine release and reuptake. Altered dopamine neurotransmission could disrupt satiety circuits between NAc dopamine terminals and projections to the hypothalamus. The NAc directs learning and motivated behaviours based on homeostatic needs and psychological states. Therefore, impaired dopaminergic responses to palatable food could contribute to weight gain by disrupting responses to food cues or stress, which impacts type and quantity of food consumed. Specifically, saturated fat promotes neuronal resistance to anorectic hormones and activation of immune cells that release proinflammatory cytokines. Insulin has been shown to regulate dopamine neurotransmission by enhancing satiety, but less is known about effects of diet-induced stress. Therefore, changes to dopamine signalling due to HFD warrant further examination to characterise crosstalk of cytokines with endocrine and neurotransmitter signals. A HFD promotes a proinflammatory environment that may disrupt neuronal endocrine function and dopamine signalling that could be exacerbated by the hypothalamic–pituitary–adrenal and κ-opioid receptor stress systems. Together, these adaptive changes may dysregulate eating by changing NAc dopamine during hedonic versus homeostatic food intake. This could drive palatable food cravings during energy restriction and hinder weight loss. Understanding links between HFD and dopamine neurotransmission will inform treatment strategies for diet-induced obesity and identify molecular candidates for targeted therapeutics.
      PubDate: 2021-06-28
      DOI: 10.1017/S0954422421000196
       
  • Carbohydrates deteriorate fatty liver by activating the inflammatory
           response

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      Authors: Gao; Yuqi, Hua, Rui, Hu, Kaiqiang, Wang, Zhao
      Pages: 252 - 267
      Abstract: Non-alcoholic fatty liver disease (NAFLD) was defined in 1980 and has the same histological characteristics as alcoholic liver disease except for alcohol consumption. After 40 years, the understanding of this disease is still imperfect. Without specific drugs available for treatment, the number of patients with NAFLD is increasing rapidly, and NAFLD currently affects more than one-quarter of the global population. NAFLD is mostly caused by a sedentary lifestyle and excessive energy intake of fat and sugar. To ameliorate or avoid NAFLD, people commonly replace high-fat foods with high-carbohydrate foods (especially starchy carbohydrates) as a way to reduce caloric intake and reach satiety. However, there are few studies that concentrate on the effect of carbohydrate intake on liver metabolism in patients with NAFLD, much fewer than the studies on fat intake. Besides, most of these studies are not systematic, which has made identification of the mechanism difficult. In this review, we collected and analysed data from studies on human and animal models and, surprisingly, found that carbohydrates and liver steatosis could be linked by inflammation. This review not only describes the effects of carbohydrates on NAFLD and body lipid metabolism but also analyses and predicts possible molecular pathways of carbohydrates in liver lipid synthesis that involve inflammation. Furthermore, the limitations of recent research and possible targets for regulating inflammation and lipogenesis are discussed. This review describes the effects of starchy carbohydrates, a nutrient signal, on NAFLD from the perspective of inflammation.
      PubDate: 2021-06-28
      DOI: 10.1017/S0954422421000202
       
  • Ketogenic diets and the nervous system: a scoping review of neurological
           outcomes from nutritional ketosis in animal studies

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      Authors: Field; Rowena, Field, Tara, Pourkazemi, Fereshteh, Rooney, Kieron
      Pages: 268 - 281
      Abstract: Objectives:Ketogenic diets have reported efficacy for neurological dysfunctions; however, there are limited published human clinical trials elucidating the mechanisms by which nutritional ketosis produces therapeutic effects. The purpose of this present study was to investigate animal models that report variations in nervous system function by changing from a standard animal diet to a ketogenic diet, synthesise these into broad themes, and compare these with mechanisms reported as targets in pain neuroscience to inform human chronic pain trials.Methods:An electronic search of seven databases was conducted in July 2020. Two independent reviewers screened studies for eligibility, and descriptive outcomes relating to nervous system function were extracted for a thematic analysis, then synthesised into broad themes.Results:In total, 170 studies from eighteen different disease models were identified and grouped into fourteen broad themes: alterations in cellular energetics and metabolism, biochemical, cortical excitability, epigenetic regulation, mitochondrial function, neuroinflammation, neuroplasticity, neuroprotection, neurotransmitter function, nociception, redox balance, signalling pathways, synaptic transmission and vascular supply.Discussion:The mechanisms presented centred around the reduction of inflammation and oxidative stress as well as a reduction in nervous system excitability. Given the multiple potential mechanisms presented, it is likely that many of these are involved synergistically and undergo adaptive processes within the human body, and controlled animal models that limit the investigation to a particular pathway in isolation may reach differing conclusions. Attention is required when translating this information to human chronic pain populations owing to the limitations outlined from the animal research.
      PubDate: 2021-06-28
      DOI: 10.1017/S0954422421000214
       
  • Ferroptosis Regulation by Nutrient Signalling

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      Authors: Qi; Yingao, Zhang, Xiaoli, Wu, Zhihui, Tian, Min, Chen, Fang, Guan, Wutai, Zhang, Shihai
      Pages: 282 - 294
      Abstract: Tremendous progress has been made in the field of ferroptosis since this regulated cell death process was first named in 2012. Ferroptosis is initiated upon redox imbalance and driven by excessive phospholipid peroxidation. Levels of multiple intracellular nutrients (iron, selenium, vitamin E and coenzyme Q10) are intimately related to the cellular antioxidant system and participate in the regulation of ferroptosis. Dietary intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) regulates ferroptosis by directly modifying the fatty acid composition in cell membranes. In addition, amino acids and glucose (energy stress) manipulate the ferroptosis pathway through the nutrient-sensitive kinases mechanistic target of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). Understanding the molecular interaction between nutrient signals and ferroptosis sensors might help in the identification of the roles of ferroptosis in normal physiology and in the development of novel pharmacological targets for the treatment of ferroptosis-related diseases.
      PubDate: 2021-07-08
      DOI: 10.1017/S0954422421000226
       
  • Aspirin and omega-3 polyunsaturated fatty acid use and their interaction
           in cardiovascular diseases and colorectal adenomas

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      Authors: Wang; Ivan E., Yi, Shana, Block, Robert C., Mousa, Shaker A.
      Pages: 295 - 307
      Abstract: Aspirin (acetylsalicylic acid, ASA) is inexpensive and is established in preventing cardiovascular disease (CVD) and colorectal adenomas. Omega-3 (n3) polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have also shown benefit in preventing CVD. The combination could be an effective preventative measure in patients with such diseases. ASA and n3 PUFA reduced the risk of CVD in ASA-resistant or diabetic patients. EPA- and DHA-deficient patients also benefited the most from n3 PUFA supplementation. Synergistic effects between ASA and EPA and DHA are ‘V-shaped’ such that optimal ASA efficacy is dependent on EPA and DHA concentrations in blood. In colorectal adenomas, ASA (300 mg/d) and EPA reduced adenoma burden in a location- and subtype-specific manner. Low doses of ASA (75–100 mg/d) were used in CVD prevention; however, ultra-low doses (30 mg/d) can also reduce thrombosis. EPA-to-DHA ratio is also important with regard to efficacy. DHA is more effective in reducing blood pressure and modulating systemic inflammation; however, high-dose EPA can lower CVD events in high-risk individuals. Although current literature has yet to examine ASA and DHA in preventing CVD, such combination warrants further investigation. To increase adherence to ASA and n3 PUFA supplementation, combination dosage form may be required to improve outcomes.
      PubDate: 2021-07-13
      DOI: 10.1017/S0954422421000238
       
  • Nutritional consequences and management of hyperemesis gravidarum: a
           narrative review

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      Authors: Maslin; Kate, Dean, Caitlin
      Pages: 308 - 318
      Abstract: Hyperemesis gravidarum (HG) is a condition at the extreme end of the pregnancy sickness spectrum, estimated to affect 1–2 % of pregnant women. This narrative review provides an overview of the current literature concerning the nutritional implications and management of HG. HG can persist throughout pregnancy, causing malnutrition, dehydration, electrolyte imbalance and unintended weight loss, requiring hospital admission in most cases. In addition to its negative effect on maternal, physical and psychological wellbeing, HG can negatively impact fetal growth and may have adverse consequences on the health of the offspring. HG care and research have been hampered in the past due to stigma, inconsistent diagnostic criteria, mismanagement and lack of investment. Little is known about the nutritional intake of women with HG and whether poor intake at critical stages of pregnancy is associated with perinatal outcomes. Effective treatment requires a combination of medical interventions, lifestyle changes, dietary changes, supportive care and patient education. There is, however, limited evidence-based research on the effectiveness of dietary approaches. Enteral tube feeding and parenteral nutrition are generally reserved for the most intractable cases, where other treatment modalities have failed. Wernicke encephalopathy is a rare but very serious and avoidable consequence of unmanaged HG. A recent priority-setting exercise involving patients, clinicians and researchers highlighted the importance of nutrition research to all. Future research should focus on these priorities to better understand the nutritional implications of HG. Ultimately improved recognition and management of malnutrition in HG is required to prevent complications and optimise nutritional care.
      PubDate: 2021-09-16
      DOI: 10.1017/S0954422421000305
       
 
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