Subjects -> MEDICAL SCIENCES (Total: 8196 journals)
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GERONTOLOGY AND GERIATRICS (125 journals)                     

Showing 1 - 122 of 122 Journals sorted alphabetically
Activities, Adaptation & Aging     Hybrid Journal   (Followers: 6)
Advances in Alzheimer's Disease     Open Access   (Followers: 8)
Advances in Geriatrics     Open Access   (Followers: 4)
Advances in Gerontology     Partially Free   (Followers: 9)
Advances in Parkinson's Disease     Open Access   (Followers: 2)
Age and Ageing     Hybrid Journal   (Followers: 106)
Aging & Mental Health     Hybrid Journal   (Followers: 40)
Aging and Cancer     Open Access   (Followers: 2)
Aging and Health Research     Open Access   (Followers: 1)
Aging Clinical and Experimental Research     Hybrid Journal   (Followers: 3)
Aging Medicine     Open Access   (Followers: 1)
Aging, Neuropsychology, and Cognition     Hybrid Journal   (Followers: 41)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 50)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 5)
American Journal of Alzheimer's Disease and Other Dementias     Hybrid Journal   (Followers: 21)
American Journal of Geriatric Psychiatry     Hybrid Journal   (Followers: 19)
Anales en Gerontología     Open Access  
Angewandte GERONTOLOGIE Appliquée     Full-text available via subscription  
Annual Review of Gerontology and Geriatrics     Hybrid Journal   (Followers: 14)
Arthritis und Rheuma     Hybrid Journal  
Australasian Journal On Ageing     Hybrid Journal   (Followers: 12)
Australian Ageing Agenda     Full-text available via subscription   (Followers: 5)
B&G Bewegungstherapie und Gesundheitssport     Hybrid Journal   (Followers: 2)
Biogerontology     Hybrid Journal   (Followers: 1)
BMC Geriatrics     Open Access   (Followers: 17)
Canadian Geriatrics Journal     Open Access   (Followers: 6)
Canadian Journal on Aging     Hybrid Journal   (Followers: 17)
Clinical Gerontologist     Hybrid Journal   (Followers: 3)
Clinics in Geriatric Medicine     Full-text available via subscription   (Followers: 6)
Current Geriatrics Reports     Hybrid Journal   (Followers: 1)
Current Gerontology and Geriatrics Research     Open Access   (Followers: 11)
Dementia and Geriatric Cognitive Disorders     Full-text available via subscription   (Followers: 36)
Dementia and Geriatric Cognitive Disorders Extra     Open Access   (Followers: 19)
Drugs & Aging     Full-text available via subscription   (Followers: 10)
European Geriatric Medicine     Full-text available via subscription   (Followers: 3)
European Journal of Ageing     Hybrid Journal   (Followers: 16)
European Review of Aging and Physical Activity     Open Access   (Followers: 11)
Experimental Aging Research: An International Journal Devoted to the Scientific Study of the Aging Process     Hybrid Journal   (Followers: 2)
Experimental Gerontology     Hybrid Journal   (Followers: 5)
Frontiers in Aging Neuroscience     Open Access   (Followers: 22)
Gait & Posture     Hybrid Journal   (Followers: 17)
Generations     Full-text available via subscription   (Followers: 3)
Geriatric Care     Open Access   (Followers: 4)
Geriatric Medicine in General Practice     Full-text available via subscription   (Followers: 8)
Geriatric Orthopaedic Surgery Rehabilitation     Open Access   (Followers: 5)
Geriatrics     Open Access   (Followers: 3)
Geriatrics & Gerontology International     Hybrid Journal   (Followers: 12)
Geriatrie up2date     Hybrid Journal  
Geriatrie-Report : Forschung und Praxis in der Altersmedizin     Full-text available via subscription  
Gerodontology     Hybrid Journal   (Followers: 2)
Gerokomos     Open Access   (Followers: 1)
Geron     Full-text available via subscription  
Gerontologia     Open Access  
Gerontology     Full-text available via subscription   (Followers: 22)
Gerontology & Geriatrics Education     Hybrid Journal   (Followers: 8)
Gerontology and Geriatric Medicine     Open Access   (Followers: 5)
GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry     Hybrid Journal   (Followers: 5)
GeroScience : Official Journal of the American Aging Association (AGE)     Hybrid Journal   (Followers: 8)
Global Journal of Geriatrics Nursing     Open Access   (Followers: 4)
Hip International     Hybrid Journal  
I Advance Senior Care     Full-text available via subscription  
Immunity & Ageing     Open Access   (Followers: 9)
Innovation in Aging     Open Access   (Followers: 1)
International Journal of Ageing and Later Life     Open Access   (Followers: 1)
International Journal of Aging and Human Development     Full-text available via subscription   (Followers: 11)
International Journal of Alzheimer's Disease     Open Access   (Followers: 8)
JMIR Aging     Open Access  
Journal for Healthcare Quality     Hybrid Journal   (Followers: 28)
Journal of Adult Protection, The     Hybrid Journal   (Followers: 16)
Journal of Aging and Environment     Hybrid Journal   (Followers: 4)
Journal of Aging and Health     Hybrid Journal   (Followers: 28)
Journal of Angiogenesis Research     Open Access   (Followers: 2)
Journal of Applied Gerontology     Hybrid Journal   (Followers: 18)
Journal of Elder Abuse & Neglect     Hybrid Journal   (Followers: 6)
Journal of Frailty & Aging     Hybrid Journal  
Journal of Geriatric Cardiology     Open Access   (Followers: 3)
Journal of Geriatric Mental Health     Open Access   (Followers: 6)
Journal of Geriatric Oncology     Hybrid Journal   (Followers: 2)
Journal of Geriatric Physical Therapy     Hybrid Journal   (Followers: 14)
Journal of Geriatrics     Open Access   (Followers: 1)
Journal of Geriatrics and Palliative Care     Open Access   (Followers: 5)
Journal of Gerontological Social Work     Hybrid Journal   (Followers: 14)
Journal of Mid-life Health     Open Access  
Journal of Military and Veterans Health     Full-text available via subscription   (Followers: 7)
Journal of Parkinsonism and Restless Legs Syndrome     Open Access   (Followers: 2)
Journal of Parkinson’s Disease and Alzheimer’s Disease     Open Access   (Followers: 1)
Journal of Prevention of Alzheimer's Disease     Hybrid Journal   (Followers: 1)
Journal of Religion Spirituality & Aging     Hybrid Journal   (Followers: 7)
Journal of Social Work in End-of-Life & Palliative Care     Hybrid Journal   (Followers: 22)
Journal of the American Geriatrics Society     Hybrid Journal   (Followers: 68)
Journal of the Indian Academy of Geriatrics     Open Access   (Followers: 4)
Maturitas     Hybrid Journal   (Followers: 10)
Medycyna Wieku Podeszłego (Geriatric Medicine)     Open Access  
Mortality: Promoting the interdisciplinary study of death and dying     Hybrid Journal   (Followers: 9)
Neurodegenerative Diseases     Full-text available via subscription   (Followers: 1)
Neuroembryology and Aging     Full-text available via subscription   (Followers: 1)
NOVAcura     Hybrid Journal  
npj Aging and Mechanisms of Disease     Open Access   (Followers: 1)
npj Parkinson's Disease     Open Access   (Followers: 4)
Nursing Older People     Full-text available via subscription   (Followers: 9)
OA Elderly Medicine     Open Access  
Paediatrics & Child Health in General Practice     Full-text available via subscription   (Followers: 5)
Palliative Care & Social Practice     Open Access   (Followers: 3)
Parkinson's Disease     Open Access   (Followers: 12)
Pathobiology of Aging & Age-related Diseases     Open Access  
Physical & Occupational Therapy in Geriatrics     Hybrid Journal   (Followers: 56)
Quality in Ageing and Older Adults     Hybrid Journal   (Followers: 44)
Quality of Life Research     Hybrid Journal   (Followers: 20)
RASP - Research on Ageing and Social Policy     Open Access   (Followers: 4)
Revista Española de Geriatría y Gerontología     Full-text available via subscription  
Senex: Yaşlılık Çalışmaları Dergisi / Senex: Journal of Aging Studies     Open Access  
The Aging Male     Hybrid Journal   (Followers: 2)
The Gerontologist     Hybrid Journal   (Followers: 23)
The Journals of Gerontology : Series A     Hybrid Journal   (Followers: 22)
Topics in Geriatric Rehabilitation     Hybrid Journal   (Followers: 15)
Translational Medicine of Aging     Open Access  
Work, Aging and Retirement     Open Access   (Followers: 4)
Working with Older People     Hybrid Journal   (Followers: 40)
Zeitschrift fur Gerontologie und Geriatrie     Hybrid Journal   (Followers: 1)
Zeitschrift für Gerontopsychologie und -psychiatrie     Full-text available via subscription   (Followers: 1)
Zeitschrift für Palliativmedizin     Hybrid Journal  

           

Similar Journals
Journal Cover
Advances in Gerontology
Journal Prestige (SJR): 0.144
Number of Followers: 9  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 2079-0570 - ISSN (Online) 2079-0589
Published by Springer-Verlag Homepage  [2469 journals]
  • Perceptions of Caregiving by Family Caregivers of Older Adults with
           Dementia in Iran: A Qualitative Study

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      Abstract: The concept of caring appraisal, which includes positive and negative aspects of care, has been considered as one of the key concepts in caregivers’ studies and is affected by the knowledge, attitudes, values, beliefs, and social norms in their society. In this respect, the perception of family caregivers’ can be studied from a cultural perspective. The aim of the present study was to explore the self-appraisal concept of caring based on the experience of family caregivers of older adults with dementia in Iran. In this qualitative study, data were collected through in-depth, semi-structured interviews. Twelve participants (family caregivers of elderly with dementia) were interviewed between January and September 2016. The transcribed texts were analyzed using inductive qualitative content analysis recommended by Graneheim and Lundman (2004). Six main categories were extrapolated: “Perceived burden,” “Satisfaction with care,” “Personal growth,” “Caregiving gains,” “Philosophy of care” and “Loss and threat.” According to the findings, the family caregivers’ appraisal of their care not only included negative aspects, but also covered a number of positive aspects, which in them the cultural and social factors prevailing in Iranian society played a significant role.
      PubDate: 2022-06-01
       
  • Comparison of Older Primary Healthcare Workers with Non-Older Workers in
           Terms of Working Life, Quality of Life and Health Problems in Turkey

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      Abstract: With the rapid growth of aging all over the world, it was reported that the proportion of older workers in employment would increase. It was aimed to comparison of older primary healthcare workers with non-older workers in terms of working life, quality of life and health problems in Mugla, Turkey. This cross-sectional was conducted in primary healthcare workers in Mugla. In the study population of 176 workers, 171 were responded, 73 of them were older and 98 of them were non-older workers. Older and non-older healthcare workers were compared in terms of working life, quality of life and health problems. In terms of working life characteristics; the thought of difficulty in finding a new work, exposure to physical violence and to chemical solids or liquids were found to be more favorable in non-older healthcare workers, other characteristics were found to be more favorable in older healthcare workers. In terms of quality of life characteristics; older healthcare workers were generally better. In terms of health problems characteristics; the presence of chronic disease, the frequency of going to a health institution and the difficulty of urination were found to be more favorable in non-older healthcare workers, other characteristics were found to be more favorable in older healthcare workers. It was concluded that older healthcare workers were in a better condition than non-older healthcare workers in terms of many characteristics. With this study which was a pioneer in the field, researches on older workers should be supported with funding.
      PubDate: 2022-06-01
       
  • Modern Approach and Geriatric Aspects of Teaching Gerontostomatology in
           Training Specialists under the Specialty Program

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      Abstract: The strategy of dental care for older age groups is based not only on the priorities determined by the demographic situation (guided by its development and the epidemiologically justified need for dental care), but also on improving the effectiveness of care, which must be based on the results of evidence-based medicine, as well as a personalized approach, implemented through the competencies taught to gerontostomatology students at dentistry schools. The aim of the work is to create a modern methodological basis for teaching the section of gerontostomatology within the modern dentistry curriculum. Based on the study of scientific works devoted to various aspects of gerontostomatology, the work presents the methodological foundations for modern teaching of the section of gerontostomatology as a specialty program at dentistry schools, focusing on the main areas of the specialist training curriculum such as cariesology, non-carious dental lesions, endodontics, periodontology, diseases of the mucous membrane of the oral cavity, and the basics of providing orthopedic dental care to the elderly and senile people.
      PubDate: 2022-06-01
       
  • Leukocyte Telomere Length and Response to Antiangiogenic Therapy in
           Patients with Neovascular Age-Related Macular Degeneration

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      Abstract: Age-related macular degeneration (AMD) is becoming the leading cause of vision loss in people over 60 yr of age. The neovascular form of AMD (nAMD) is characterized by choroidal neovascularization (CNV), the main trigger of which is vascular endothelial growth factor (VEGF), the inhibition of which is the current standard of treatment. Significant variability of response to anti-VEGF therapy determines the relevance of the search for biological markers—prognostic criteria of treatment response. We analyzed the response of 110 nAMD patients to anti-VEGF therapy depending on the functional and anatomical parameters of the retina (according to optical coherence tomography, OCT) and leukocyte telomere length (LTL, was assessed by quantitative PCR). Positive dynamics of best corrected visual acuity (BCVA) was observed in 100% of eyes. The central retinal thickness (CRT) decreased after the 3rd injection to 265 [234–306] µm, by the end of the observation period—to 211 [190–262] µm. The retention of activity of the subretinal neovascular membrane (SNM) at the end of the observation period correlated with lower values of the initial BCVA and high values of the initial CRT. An association of LTL with response to treatment was revealed: in patients with longer LTL the active form of SNM was more often switched to inactive after three injections, while with shorter LTL, the activity of SNM was more often preserved, which determined the need for more intravitreal injections.
      PubDate: 2022-06-01
       
  • Abuse and Neglect of Community-Dwelling Older Adults: Index Generation, an
           Assessment of Intensity, and Implications for Ageing in Place

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      Abstract: Abuse and neglect of older adults in the community are a threat to aging in place programs. Recently, some researchers constructed the first scale for assessing elderly abuse and neglect in the neighborhood for research and routine monitoring. This study provides a protocol for generating an index from this tool and assessing the intensity of abuse and neglect. Implications for aging in place are also provided. This study adopted a cross-sectional study and an analysis of secondary data on 515 community-dwelling older adults aged 60 years or higher. Standards in the literature were followed to develop a protocol for generating an index and assessing the intensity of abuse and neglect. The abuse and neglect scale has index scores ranging between 1 and 33, which means that the average score from the index that indicates the intensity of abuse and neglect would fall between this range. We found that abuse and neglect were moderate for the whole scale and the domain “discrimination and harassment” but was high for the domain “neglect and assault.” The dichotomization of the scale showed that high abuse and neglect can be associated with an increase or decrease in social activity. The abuse and neglect scale can be used as a monitoring tool to routinely assess the intensity of elderly abuse and neglect. The dichotomization of the scale can reveal how the highest level of abuse and neglect is affecting behaviors in community-dwelling older adults.
      PubDate: 2022-06-01
       
  • Comparative Analysis of Quality of Life and Attachment Style among Cancer
           and Dementia Informal Caregivers

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      Abstract: To record and compare the quality of life and attachment style of dementia and cancer caregivers. This is a comparative prospective cross sectional study. Participants were 45 caregivers of patients with cancer and 45 caregivers of patients with dementia. The study was conducted at a University Hospital and from a Day Centre of Alzheimer Disease and related disorders Association in Athens. Quality of caregivers’ life was measured by the Short Form 36 Health Survey Questionnaire (SF-36) and caregivers’ attachment was evaluated by the Experience in Close Relationships—Short Form (ECR). Caregivers’ age (cancer caregivers’ age Mean = 52.4 and SD ± 12.21, dementia caregivers’ age Mean = 58.4 and SD ± 12.8) differed significantly across diagnostic groups (p < 0.005). Dementia patients were older than cancer patients (dementia patients’ age Mean = 76.8, cancer patients’ age Mean = 65, p < 0.001). Statistically significant difference was found between two groups regarding the duration of the disease. The duration of disease in dementia patients (Mean = 3.14 years) was significantly longer (p = 0.014) than in cancer patients (Mean = 1.23 years). Subscale scores in both instruments (SF-36 and ECR), showed no statistically significant differentiation. Our data showed no statistically significant differentiation in any subscale between cancer and dementia caregivers. However, both caregiver groups noticed remarkably low levels of mental health.
      PubDate: 2022-06-01
       
  • Astragalus membranaceus Increases Leukocyte Telomere Length, but Does Not
           Suppress Development of Accelerated Senescence Signs in OXYS Rats

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      Abstract: Astragalus membranaceus (AM) was used for millennia by traditional Chinese medicine to slow down aging and extend lifespan. It has been shown that AM can affect all key hallmarks of aging including compensating telomere shortening which is recognized as one of the most reliable biomarkers of aging. The telomere shortening in peripheral blood leukocytes is viewed as a promising biomarker in predicting the risk of age-related diseases as well as a biomarker of the effectiveness of treatment. However, findings from epidemiological studies on the links between leukocyte telomere length (LTL) and age-related diseases are rather contradictory. The present study is aimed to investigate the effect of AM on the LTL and the AM influence on the manifestation and development of the sings of accelerated senescence in OXYS rats. Animals were given AM root powder (100 mg/kg) from 3 to 6 months of age. Our study confirmed the ability of AM to activate telomerase, as evidenced by an increase in LTL in OXYS rats. However, LTL lengthening was not accompanied by a delay of the accelerated senescence of OXYS rats, manifested as the early development of cataract, retinopathy similar to age-related macular degeneration and accelerated brain aging. Thus, we have demonstrated a limitation of using LTL as indicator for assessing the effectiveness of anti-aging therapy.
      PubDate: 2022-06-01
       
  • Changes in the Number of p23-Positive Fibroblasts in Human Dermis with
           Aging

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      Abstract: The aim of this work was to examine the content of p23 in fibroblasts of the human dermis from 20 weeks of gestation until 85 years old and to define the role of p23 in age-dependent changes in the number and proliferation of fibroblasts in the dermis. p23, proliferating cells nuclear antigen (PCNA), and the fibroblasts marker vimentin were detected with the indirect immunohistochemical technique. The results showed that the portion of fibroblasts with positive staining for p23 in the dermis gradually increases from 20 weeks of gestation until 85 years old. Age-related increase in the portion of fibroblasts with positive staining for p23 is significantly correlated with age-related decrease in the total number and percent of PCNA-positive fibroblasts in the human dermis. Age-related increase in the content of p23 in fibroblasts is involved in age-dependent decrease in their total number and proliferation in the dermis.
      PubDate: 2022-06-01
       
  • Experimental Studies of Geroprotective and Anti-Aging Effects of Chemical
           Compounds of Portulaca oleracea L. (Review)

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      Abstract: The analysis presented in the review of publications shows that extract of Portulaca oleracea L. or its individual components (polysaccharides, oleracea, alkaloids tetrahydroisoquinoline operatein E) is able to increase the lifespan of laboratory animals, to activate telomerase and increase telomere length, and to provide antioxidant and antiosteoclastogenic impact. Various neuroprotective effects (improvement of memory and learning ability, inhibition of acetylcholinesterase, protection of dopaminergic neurons, improvement of motor functions, etc.) are of interest for the prevention of syndromes associated with age-related degradation of the nervous system such as Alzheimer’s and Parkinson’s diseases. In addition, regular consumption of vegetable portulaca in food leads to a decrease in the percentage of cancer and cardiovascular diseases, which also directly provides an increase in the average life expectancy of the population.
      PubDate: 2022-06-01
       
  • Ageist Attitudes: Youth Identity, Subjective Time to Become Older, and
           Impressions of the General Older Population’s Physical and Mental Health
           

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      Abstract: Reduction in ageist attitudes is crucial to resolve intergenerational conflicts between older adults and other generations. As factors related to ageist attitudes, the extent to which people perceive themselves to be young should be the focus. The perceived link between older adults and illness also has a significant relationship with ageist attitudes. This study examines the relationship between ageist attitudes and youth identity (the extent to which people feel they belong to the young population as opposed to the older population), and impressions of the physical and mental health of the general older population. The results of an online survey of Japanese participants (n = 474) showed that those with higher youth identity held stronger ageist attitudes. While impressions of the physical health of the general older population were not associated with ageist attitudes, participants with more positive impressions of older adults’ mental health had weaker ageist attitudes. Future research should extend our model by adding factors not considered in this study.
      PubDate: 2022-06-01
       
  • Age-Associated Features of the Expression Level of Apoptosis Markers in
           Cardiomyocytes of Patients with Dilated Cardiomyopathy

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      Abstract: To understand the pathogenesis of dilated cardiomyopathy (DCMP), it is necessary to establish the molecular and cellular mechanisms of myocardial aging, including those associated with programmed cell death, the molecular mechanisms of which have not been extensively studied. The aim of this work is to study markers of apoptosis in cardiomyocytes of patients with DCMP in vitro. We used the method of primary dissociated cell cultures and the method of immunofluorescence confocal laser microscopy. Cells of the 3rd and 14th passages, corresponding to “young” and “old” cultures, were used to simulate cellular senescence. At the molecular level, aging of cardiomyocyte cells was accompanied by a twofold increase in the expression of p16INK4a compared to “young” cultures, both in the control group and in the group with DCMP. It was also found that the expression of p16INK4a in cultures taken from patients with pathology was two times higher than in similar cultures from healthy patients. The expression of p21 was increased in the group with DCMP compared to the control; however, with aging of the culture, the expression of p21 did not change, remaining at a significant level. The most significant (3.2-fold) differences were obtained when comparing the expression of Bax in the cell culture of cardiomyocytes from the group with DCMP in the “young” culture compared with the control. Aging of myocardial cells at the molecular level was manifested in an increase in the expression of the Bax protein, which is the triggering mechanism of the mitochondrial apoptosis pathway. It is possible that this pathway of cell death is prevalent in DCMP.
      PubDate: 2022-06-01
       
  • Piezopulsometric Analysis of Autonomous Regulation of the Cardiovascular
           System in an Elderly Person under Stress

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      Abstract: The results of the application of a new method of arterial piezopulsometry for noninvasive assessment of the functional state and physiological mechanisms of autonomous regulation of the cardiovascular system (CVS) in an elderly person with acute pain associated with unexpected physical trauma are described. Such exposure caused a negative stress response in the muscle effectors (MEs) of CVS on the first day, provoking an abnormal increase and acceleration of LV myocardial contractility. Analysis of the arterial blood pressure pulse (PP) wave graphs shows that the maximum rate of PP growth, VmaxPP, reflecting the myocardial contractility, increased from 625 ± 74 before the trauma to 2117 ± 173 mm Hg/s after the trauma, distorting the waveform of the normal graph. The cause of this increase could be the rapid total effect of transmitters of the neuroendocrine sympathoadrenal system on the adrenergic receptors (ARs) of cardiomyocytes (CMs). The results of the spectral analysis of the variability of the PP wave parameters confirm this possibility. It is shown that under stress, norepinephrine from activated sympathetic efferents is added to the already increased content of humoral catecholamines in the extracellular environment of the myocardium near ARs of CMs, which is typical for older people. At the same time, the activity of parasympathetic efferents that release acetylcholine, which inhibits the contractile reaction of the myocardium and, thereby, performs a restraining cardioprotective function, significantly increases. A personalized approach was used to study the mechanisms of autonomous regulation of CVS MEs under stress.
      PubDate: 2022-06-01
       
  • AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of
           Skin Fibroblasts

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      Abstract: Ultraviolet (UV) radiation is one of the main environmental factors leading to oxidative stress and accelerated skin aging. AEDG peptide, a regulator of pineal gland functions, has demonstrated geroprotective and antioxidant effects in in vivo and in vitro studies. The aim of this research was to evaluate the effect of AEDG peptide on the expression of genes encoding enzymes of the antioxidant system (NQO1, SOD1, CATALASE, and TRXR) in human skin fibroblasts in a model of accelerated aging induced by UV radiation. The expression of SOD1 and TXNRD1 genes during UV-induced aging of dermal fibroblasts increases by 2 and 1.7 times, respectively. This can be considered as a defense mechanism against oxidative stress caused by UV radiation. Photoaging does not influence the expression of the NQO1 and CATALASE genes in the culture of skin fibroblasts. AEDG peptide promotes the expression of the SOD-1, NQO1, and CATALASE genes in dermal fibroblasts exposed to UV radiation by 2.7, 2.6, and 3.2 times, respectively. AEDG peptide can stimulate the expression of these genes via the Keap1/Nrf2 signaling pathway. AEDG peptide might be potentially effective in preventing the accelerated aging of dermal fibroblasts.
      PubDate: 2022-06-01
       
  • Morphological Signs of Neurogenic Inflammation in the Heart of Rats during
           Aging

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      Abstract: Cellular changes in different parts of the heart of Wistar rats at the age of 18–23 months are studied using histological methods of staining with toluidine blue, hematoxylin-eosin, and immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase (TH), and Iba-1 protein. Focal inflammatory infiltrates are found in the connective tissue of the heart base, near which PGP 9.5+ and TH+ plexuses consisting of parasympathetic and sympathetic nerve fibers are detected. In the area of the valvular heart apparatus and at the border between the fibrous ring and myocardium of the right atrium, the following pathological changes in nerve structures are observed: degeneration of nerve fibers and granular destruction of varicose axons of the terminal plexus. A close relationship is established between the axons of the terminal neural network and cells of inflammatory infiltrates and blood capillaries. The features of the localization of neurocellular inflammatory complexes consisting of nerve fibers, blood capillaries, and cells participating in the local inflammatory process (mast cells, macrophages, fibroblasts, and plasma cells) are described in various parts of the myocardium in old animals. The chronic nature of neurogenic inflammation is determined for the heart during aging.
      PubDate: 2022-06-01
       
  • Is Ketogenic Diet Therapy a Remedy for Alzheimer’s Disease or Mild
           Cognitive Impairments': A Narrative Review of Randomized Controlled
           Trials

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      Abstract: Alzheimer’s disease (AD) is the most common form of dementia and is estimated to increase further due to the aging of the world population. Since preventive strategies or effective treatment for AD have not been defined yet, studies on metabolism and nutritional approaches have gained attention. A present literature review aimed to provide a summary of current evidence on the neuroprotective roles of ketogenic diets. A literature search was conducted on the MEDLINE, EMBASE, and CENTRAL databases for clinical trials that published in English and focused ketogenic therapy in AD or mild cognitive impairment. The neuroprotective potential of ketone bodies is based on mitochondrial dysfunction, suppression of oxidative damage and inflammation, reduction of the negative effects of impaired glucose metabolism in the brain, and effects at the genomic level. Clinical studies mainly provide evidence of improved verbal memory, attention, and total cognitive function. But optimal procedures have not yet been clarified. Also, ketogenic diet practices in older adults may pose several risks in long term. Therefore, further clinical research will shed more light on the neuroprotective effect, safety, and sustainability of the ketogenic diet, which is promising in the protection or improvement of cognitive functions.
      PubDate: 2022-06-01
       
  • Design and Evaluation of an Educational Intervention to Prepare
           Close-to-Retirement Employees for Retirement

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      Abstract: This study aimed to assess the effect of an educational intervention for preparing close-to-retirement employees for their retirement. This randomized pre/post interventional study was conducted among 140 employees of Kerman University of Medical Sciences. The 70 employees in the intervention group were educated in four 4 h sessions, including health, leisure time, and financial needs. The instrument used was the Retirement Syndrome Questionnaire. Findings show that feelings of helplessness and failure and oldness and idleness significantly decreased after the educational intervention, and feelings of effort and a new direction significantly increased. The educational intervention led to the improvement of retirement syndrome in the studied population. Therefore, to help them adjust to retirement, it is essential to consider retirees’ challenges and increase their awareness about retirement requirements by providing social support and educational courses.
      PubDate: 2022-06-01
       
  • Puberty Start of Girls Residing in Urban and Rural Areas of the Turkestan
           Region

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      Abstract: Our research has shown that the maximum changes of somatometric indices in girls of observed groups began in the early adolescence and continued until the end of adulting. All physical parameters during the height of their increase in the early adolescence were lower in rural adolescents than in urban peers. In the childhood period no differences in the formulas of sexual development were found in girls in rural and urban areas. In the early adolescence, the formula for urban adolescents was: P0.1Ax1.2Ma1–4Me+, for adolescents from the village—P0Ax1Ma1–3Me+. In late adolescence, there was a decrease in the growth rate of physical parameters, while signs of puberty, on the contrary, increased. In late adolescence, all sexual characteristics are detected in adolescents of both groups, P2–4Ax3–4Ma2–4Me+ and, accordingly, in adolescents from the village P2–4Ax2–4Ma1–3Me+. And the ending of the reproductive period had its differences in rural and urban women. For the urban women, menopause age consisted of 46.80 ± 0.09, and for the rural citizens was 48.23 ± 0.11. It can be assumed that the great significance in development processes belongs to such factors as poor or deficient nutrition of children in the rural area, excessive physical activity as a result of participation in agricultural work and bad medical assistance of the girls’ adolescent period in the rural area. The research data showed the beginning of the menopause was earlier in the urban citizens.
      PubDate: 2022-03-01
      DOI: 10.1134/S2079057022010040
       
  • Chronological Age and Subjective Perception of the Old-Age Threshold: An
           Empirical Verification of the Age-Group Dissociation Effect Using European
           Social Survey Data

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      Abstract: As people get older, they perceive old age as starting later. Such phenomenon is explained by the so-called “age-group dissociation effect.” Since old people (as a part of society) and old age (as a stage of life) are the source of negative connotations, people tend to mentally distance from them in order to avoid stigma and to improve personal well-being. This study aims to investigate the impact of the attitude towards old people on the mental distance separating from the old-age threshold. Using data from European Social Survey (round 4), two measurement tools were developed: Ageism Index (AI) and Modified Mental Distance (MMD). The obtained results indicated no linear relationship between these two parameters. As so, no empirical evidence that supports the “age-group dissociation effect” hypothesis was found.
      PubDate: 2022-03-01
      DOI: 10.1134/S2079057022010052
       
  • Methods of Art Therapy in Psychogerontological Practice

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      Abstract: This article deals with the use of art-therapy methods in the complex psychological support of the elderly and senile age groups. The study was conducted on the basis of the Comprehensive Center of Social Services for the Population of the Birsk District and the City of Birsk of the Republic of Bashkortostan and Polyclinic no. 1 of Ufa; the total sample was 60 respondents at ages of 60–80 years. The analysis of the results revealed that the use of the art therapy program with the gradual enrichment and complication of art therapy classes stimulates new life orientations and the individual’s awareness of the presence of other psychological characteristics that allow the subject to function successfully in real life.
      PubDate: 2022-03-01
      DOI: 10.1134/S2079057022010131
       
  • Evaluation of Psychiatric Consultations of Elderly Hospitalized Patients:
           What are the Psychological Complaints and Diagnoses'

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      Abstract: In the aging world population, inpatient services for elderly patients have become an increasingly important issue. These patients may have accompanying psychological problems and mental disorders. Psychological evaluations of the patients, in which situations psychiatric consultation should be requested and the principles of psychiatric approach should be determined. This study aimed to determine the risk factors leading to psychiatric consultation in elderly hospitalized patients, determine psychiatric comorbidities, and determine the role of psychiatric consultations in psychopharmacological treatment. All psychiatric consultations requested from patients over 65 years of age hospitalized patients in University of Health Sciences Ankara City Hospital from September 2019 to March 2020 (189 male and 137 female, in total 326) were evaluated. The files of the patients were examined retrospectively through the hospital system, and the information was recorded in the data collection form. This form includes the following information: sociodemographic characteristics, hospitalization service, the reason for hospitalization, additional diseases other than hospitalization diagnosis, duration of hospitalization, the reason for requesting psychiatric consultation, diagnosis after psychiatric consultation, psychotropic drugs used before the consultation, psychotropic drugs recommended after consultation, the total number of drugs used. While agitation is the most common reason for psychiatry consultation in elderly patients, the most common psychiatric disease diagnosis is delirium. Drug treatment was not recommended to almost one-third of the patients, and recommendations were made to increase psychosocial and treatment compliance regarding their complaints. Patients diagnosed with delirium have higher re-consultation rates. Haloperidol and quetiapine are the most commonly recommended psychotropic. Sertraline and escitalopram are the most commonly recommended antidepressants in elderly hospitalized patients. Psychiatric consultations should be planned without workforce loss, and in a more qualified way, pharmacological and non-pharmacological interventions should be appropriately performed.
      PubDate: 2022-03-01
      DOI: 10.1134/S2079057022010064
       
 
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