Abstract: Ostomy patients are subject to significant negative psychological impact, affecting their quality of life in all respects (physical, psychological, social, economic, and spiritual), especially if they are not properly constructed or if there are complications during the recovery phase. In the light of published research and studies, the main problems are as follows: a) alteration of body image; loss of sphincter control; b) odor, leakage, and complications related to the stoma; c) impairment of sexuality; d) alteration of nutrition and sleep; e) anxiety, depression, and loneliness; embarrassment and shame; f) loss of control of the situation; drop in self-esteem; g) rejection; h) stigmatization; i) disinvestment in social activities; l) abandonment of work and sports activities; isolation; m) difficulties in couple relationships and social contacts. The psychological problems caused by ostomy can be avoided, or at least contained, by comprehensive care of the patient, both before and after the operation. In addition to purely technical care, teaching, accompaniment and constant support are the main components of care that can make a difference to how the patient will accept his or her ostomy. Setting the care only on the management of the physical dimension will hardly allow the person to integrate the ostomy into his life. The present work proposes a specific protocol of psychological intervention (Perrotta-Guerrieri Psychological Care for Ostomy Patients, PCOP), for all the clinical phases (pre-operative, operative, post-operative, follow-up) and a specific questionnaire (Perrotta-Guerrieri Psychological Care for Ostomy Patients Questionnaire - first version, PCOP-Q1) to be submitted to the patient which investigates the 9 subjective functions (physical, psychological, sexual, emotional, sentimental, work, family and social), in 45 items with a response on L1-5 scale, for the study of quality of life in the ostomised patient. PubDate: 30 Mar, 2022
Abstract: Introduction: Childhood cancer is the leading cause of death in patients aged 5-19 years. Testicular tumors (TT) comprise 1 to 2% of all pediatric solid tumors. Although rare, TTs are often misdiagnosed. Screening improves clinical practice and decision-making for early diagnosis. Objective: To analyze the screening methods for detection of pediatric testicular cancer and contribute to the management of suspected cases.Methods: We conducted an integrative systematic review of the PubMed, EMBASE, and LILACS databases limited to records published between January/2013 and August/2018. Results: Sixty articles were initially selected based on the presence of specific search terms on the article body, title, and abstract. Of those, nineteen articles were selected for a full review. Clinical signs were not evident in most studies, but 12 (63%) reported the presence of scrotal masses. Cryptorchidism, family history, and the presence of contralateral TT were identified as risk factors. Alpha-fetoprotein (AFP) was elevated in 73% of studies, but normal levels do not rule out a suspected diagnosis. Scrotal ultrasound (US) was instrumental in 73% of studies and Doppler US (32%) was able to detect nearly 100% of cases at diagnosis. Computed tomography (abdomen/chest) was required in 12 studies (63%) for confirmation of metastasis of testicular germ cell tumors. In 73% of studies, stages were subdivided based on the levels of serum tumor markers and the presence of metastasis. The inguinal-scrotal approach is suggested as the preferred method as it does not affect prognosis or require adjuvant therapy. There are minimum requirements for therapeutic retroperitoneal lymphadenectomy. In 14 studies (73%), advanced stages showed a good prognosis with surgery in combination with chemotherapy. TT histology and treatment are different for prepubertal and postpubertal patients. In the same 14 studies (73%), relapsed patients received chemotherapy. In eight studies (42%) the overall survival increased by five years and, in three of them, it increased 2 by 100% post-combination therapy. Conclusion: Few studies have evaluated the prognosis, disease recurrence, and survival rates of children with testicular cancer. AFP, US and an appropriate surgical approach provide optimal personalized treatment and minimize the adverse effects. PubDate: 28 Jul, 2022
Abstract: The unavoidable pandemic situation seems uncontrolled over the past two years. In this aggravated situation, it seems crucial to take inescapable measures to deal with such a defiant disease and it is only possible if the actual pandemic propagation ratio is to be acquainted. Therefore, a shrewd pandemic model is being developed that will generate real-time infection statistics on an hourly, weekly, and monthly basis. This shrewd model utilizes the well-known dataset and when this dataset will be applied to determine the status of three types of infection the number of infected people, the time when the pandemic begins, and the time when the pandemic disappears. The time-based results are generated by conducting simulation in python Simpy framework and the generated results are the hallmark of real-time infection spreading ratio it shows that when the extraordinary measures for infection ratio are indispensable and when it becomes plausible. PubDate: 28 Apr, 2022
Abstract: The incidence of liver cirrhosis and pancreatic cancer varies between countries and stands out as an important health problem worldwide. Liver cirrhosis is the most advanced stage of chronic liver disease and is a widespread result of chronic liver damage. The etiology of liver cirrhosis and pancreatic cancer, which are major causes of cancer fatalities in developed countries, is poorly understood. Many metabolic and physiological processes in the human body utilize trace elements. The creation and development of many diseases like cancer, cardiovascular, and diabetes mellitus occur with the disruption of trace element metabolism in the body as a result of improper nutrition, environmental, and occupational exposure, and impaired digestion and absorption.Methods and materials: In this study, copper (Cu), cadmium (Cd), iron (Fe), cobalt (Co), manganese (Mn), magnesium (Mg), nickel (Ni), zinc (Zn), and lead (Pb) concentrations were researched in the serum of liver cirrhosis and Pancreatic Cancer (PC) patients and healthy controls. Analysis of the elements was carried out by flame atomic absorption spectrophotometer.Results: Fe and Zn serum levels were considerably lower in individuals with liver cirrhosis and pancreatic cancer than in controls (p <0.001). Furthermore, mean serum levels of Cd and Mn in patients with liver cirrhosis and pancreatic Ca were considerably lower than in controls (p <0.01). In addition, when compared to pancreatic cancer, mean serum Cu and Ni levels in liver cirrhosis patients and controls were considerably lower (p <0.05). Mean serum levels of Pb in pancreatic Ca patients were significantly lower compared to liver cirrhosis patients and controls (p <0.05). When comparing all cancer patients to controls, mean serum Co and Mg levels were not substantially different.Conclusion: Deficiency in four trace elements (Cd, Mn, Fe, and Zn) was determined in patients with liver cirrhosis and pancreatic cancer. In addition, we have determined the deficiency of Cu and Ni trace elements (TEs) in pancreatic cancer patients. TE insufficiencies in cancer patients may be due to excessive consumption of foods and undernourishment. Epidemiological and physiological causes of trace element changes should be investigated further. PubDate: 28 Apr, 2022
Abstract: Community Health Workers support frontline public health professionals during times of public health pandemics by providing communities with trusted messengers that are a support system and liaison to medical and social services. North Carolina deployed Community Health Workers during the COVID-19 pandemic using funding under the Patient Protection and Affordable Care Act with success. We offer recommendations for a more robust program going forward using what was learned during the pandemic. PubDate: 27 Aug, 2022
Abstract: Introduction: Identification of COVID-19 patients at high risk of mortality is crucial to improve patient management. Our study aimed to identify mortality risk factors at the COVID-19 Intensive Care Unit (ICU), in Mahdia.Methods: We conducted a prospective study including patients admitted to the COVID-19 ICU at University Hospital Tahar Sfar Mahdia (September 2020 to February 2021). We used “The RAPID CORE CASE REPORT FORM” developed by the World Health Organization.Results: A total of 119 patients were included (60.5% male). The average age was 61.9 ± 12 years. During their stay, 51.8% of them had invasive ventilation, 31.3 % required vasopressors intake and 50.9% required a prone position. The mortality rate was 47.1%. Severe acute respiratory distress syndrome and Health Care Associated Infections (HAI) were associated with a higher risk of mortality (64.9% vs 17.8%; p PubDate: 26 Oct, 2022
Abstract: Introduction: Both the 1st-and 4th-pandemic outbreaks by SARS-CoV-2/3 causing COVID-19, starts in Wuhan, China, badly affecting human civilization with sever-post-COVID-diseases weakening the ability of COVID-19-vaccines to prevent-SARS-CoV-2/3-infection-or-reinfection with side effects. So, it will require proper COVID-booster-community-vaccines-doses to prevent ‘Omicron’ like any-‘A-to-Z’-diseases as early-as-possible, fulfilling the main objectives of the current ‘Community-Case-Study-Reports’ are to find out the most suitable ‘Biomedicines-Vaccine’. Methods: The ‘community-treatments’ were done with the mixture-extract of spices; Ginger, Garlic, and Turmeric forming the high-diluted ‘Spices-Community-Biomedicines’ dissolving @ 5-10 drops / 50ml-100ml (a half to a full cup) of moderately hot drinking water, orally administered @ 3-5 times/day at an interval of 1- 2hrs, against naturally occurring coronavirus-infections-or re-infections, for 45-60 days, before-symptom-onset OR illness-onset (as a vaccine).Results: The present-oral-‘community-treatments’ of ‘Spices-Community-Biomedicines-Physiology’ are very-much-effective in controlling-diseases-by-boosting-natural-immunity-against coronavirus-2/3 with no side effects among the students and their parent’s-community. Conclusion: The present “Community-Treatments-Case-Study-Reports of Spices-Community-Biomedicines-Physiology Act as Archives of Preventive-Booster-Community-Vaccines Against Omicron-Like-Any-‘A-to-Z’-Diseases By Immunizing Public-Health-Socio-Economy-Environment-Wildlife-Biodiversity-Conservation-Science-Technology-Communication-Applications-Ecology-Retaining-the-World-in-Old-Forms”. And only ‘Archives-community-biomedicines-physiology’ may save the world. PubDate: 25 May, 2022
Abstract: Background: The effectiveness of vaccines against COVID-19 has been demonstrated, but because new variants appear and immunity fades over time, continuous monitoring is necessary.Objectives: To determine incidence rates (IR) and risk factors of COVID-19 breakthrough infections in vaccinated people with vaccine booster (VB).Methodology: An observational, longitudinal, and prospective study of patients with COVID-19 breakthrough infections in vaccinated people with VB in a general practice setting in Toledo, Spain, for the period December 2021 to February 2022, during the wave of infections by omicron variant.Results: Forty-six cases of COVID-19 breakthrough infections with booster shot were included. The IR was 3.1 cases per 100 people with booster. The IR was higher in < 45> 65 years (4.2%), and in women (3.6%) vs. man (2.6%). The only statistically significant risk/prevention factors were the presence of diseases of the skin [RR = 2.74 (95% CI: 1.3, 5.79)], Genitourinary chronic diseases [RR = 1.87 (95% CI: 1.19, 2.95)], complex family [RR = 0.22 (CI 95%: 0.58, 0.08)] and chronic diseases of the mental group [RR = 0.4 (95% CI: 0.82, 0.2)].Conclusion: The IR of COVID-19 breakthrough infections with a booster shot, at the peak of omicron infections (December 2021-February 2022), in the general medicine clinic, Toledo, Spain, was high, suggesting modest VB protection effectiveness against symptomatic infection. Statistically significant risk and protective factors show mixed results; so, it is hypothesized that they are related to other main variables such as gender and age, and/or with risk/preventive behaviors. However, the small numbers of COVID-19 breakthrough infections with booster shots prevent definitive conclusions. PubDate: 25 Jun, 2022
Abstract: Dengue is a viral disease transmitted by arthropods. It is caused by four Ribonucleic Acids (RNA) flavivirus serotypes (dengue virus [DENV] -1, -2, -3, and -4) which are transmitted by blood-feeding mosquitoes, primarily the Aedes aegypti mosquito. The infection causes flu-like symptoms and sometimes progresses to death. PubDate: 25 Aug, 2022
Abstract: More and more data are showing a link between hemoglobin genotypes and Plasmodium falciparum malaria. In order to establish the prevalence of hemoglobin genotype variants and their association with P. falciparum malaria in children receiving postpartum care at Faith Alive Foundation Jos, Plateau State, we study the distribution of these variants. From each sample, thick and thin blood films were created, and hemoglobin genotypes were determined using electrophoresis. Out of 172 samples examined, 131 (76.16%) were infected with P. falciparum malaria while 41 (23.84%) were not infected. There was no significant difference (p> 0.05) in the distribution of P. falciparum malaria in relation to hemoglobin genotypes. P. falciparum malaria was highest in AA with 92 (70%) and SS was the least with 12 (9%). There was no significant difference (p> 0.05) in th+++e prevalence of P. falciparum malaria in relation to age. P. falciparum malaria infection was highest in the age group ≥ 12 months than age group 0 - 11 months. There was no significant difference (p> 0.05) in the prevalence of P. falciparum malaria in relation to sex. The result depicted that P. falciparum malaria infects more males than females. There was also no significant difference (p> 0.05) in the prevalence of P. falciparum malaria in relation to months. The month of September had the highest prevalence of P. falciparum malaria followed by October and August respectively. It is, therefore, recommended that public health education campaigns for mothers and healthcare givers be intensified to create awareness that will lead to the reduction of human-vector contact, especially in children. PubDate: 23 Nov, 2022
Abstract: From the extension of the COVID-19 vaccination in December 2020 to the end of the summer of 2021, cases of breakthrough Infection in vaccinated people were rare and their attack rate was low (0.01%-5.5%). Of course, in light of the increase in vaccination rates, breakthrough Infection in vaccinated people progressively could represent the majority of all COVID-19 cases. But at the end of December 2021, the world registered the highest number of COVID-19 infections in a week. Just a few months ago, the evolution that seemed reasonable was thought to be the elimination of the pandemic. But Delta, and Omicron after, arrived; and we weren’t expecting them. The latter clearly evades immunity against vaccine-based infection, and breakthrough infections are becoming more common. This situation causes certain effects at the community level and has implications for the general practitioner: 1. Availability of vaccines has brought about a change that, when they began to be applied, seemed much more promising than it is currently; 2. This context may increase denial regarding COVID-19 vaccines; 3. Vaccination has contributed to an appreciable reduction in the number of serious and critical clinical cases; 4. Attack rates in vaccinated will increase as the proportion of vaccinated increases; 5. The importance of booster doses when immunity falls; 6. Incidence rates at the community level and official diagnostic tests will no longer be important. PubDate: 21 Jan, 2022
Abstract: Importance: 1% of the United States population accounts for 20% of healthcare costs. What characterizes heavy users of the Emergency Department (UED) both demographically and clinically is an area of active research.Objective: Compare the proportion of nine common co-morbidities between heavy, moderate, and infrequent users then compare episodic and continuous heavy UED. Setting: A large metropolitan healthcare system.Participants: Heavy users were selected using a retrospective chart review of Barnes-Jewish Emergency Department records from 2010-2011. Emergency department usage for all unique patients seen in the time period specified was determined for two non-overlapping 365-day periods. Patients were stratified into 1 of 3 groups: Heavy users (> 10 visits for both periods), moderate users (5-9 visits for both periods), and infrequent users (1 visit in either the first or last period). There were 546 moderate users and 59,957 infrequent users matched 1:1 against 160 heavy users. These patients were matched for age, race, gender, and insurance. The 160 continuous heavy users were also compared to 388 patients who had> 10 visits in the first period, but not the second period, and 443 patients who had> 10 visits in the second period, but not the first. The proportion of subjects within each group was compared based on nine co-morbidities (substance abuse, mental illness, chronic pain, heart disease, lung disease, kidney disease, liver disease, cancer and stroke) using 95% confidence intervals.Results: Infrequent users had lower rates of all co-morbidities. Moderate users had similar rates of all co-morbidities to heavy users, except slightly higher CVA rates (13.7% v 10.6%; p = 0.49), lower rates for mental illness (33.3% v 43.1%; p = 0.08) and significantly lower rates for substance abuse (17% v 35%; p < 0.001). Only substance abuse demonstrated a significant difference between episodic and continuous heavy UED (35% v 23.5%; p = 0.002). Conclusion: Among nine common co-morbidities, only substance abuse rates were significantly higher among heavy users compared to matched moderate UED in our healthcare system. Infrequent users had lower rates of all co-morbidities. When comparing continuous and episodic heavy emergency department users, only substance abuse rates were significantly higher. PubDate: 17 Aug, 2022
Abstract: Adult astroblastoma is an exceedingly rare primary brain tumor. Previous reports have suggested various radiographic and histological features typical for these tumors, but the diagnosis can be challenging. We present a unique case of astroblastoma diagnosed after 13 years of treatment as a CNS embryonal neoplasm. Histologically, this tumor lacked previously identified astroblastic features such as pseudorosettes, trabeculated patterns, and hyalinized vessels. The tumor was synaptophysin positive which further confounded the diagnosis in this case. Methylation classification was performed with a high confidence match to a high-grade neuroepithelial neoplasm with a CXXC5-MN1 fusion. Molecular characterization confirmed a CXX5-MN1 fusion transcript which has been seen in at least one other instance. Though known to be involved in tumorigenesis, the roles of CXXC5 and MN1, in this case, remain unclear. We discuss the unusual histopathological features of this tumor and the value of recent updates to the WHO molecular diagnosis scheme for central nervous system tumors. We also briefly review the literature related to astroblastoma. The current case highlights our evolving recognition of atypical histological patterns for astroblastoma and the importance of new molecular profiles which can aid in the diagnosis. PubDate: 13 Sep, 2022
Abstract: Currently, the COVID-19 pandemic is one of the major health issues in the world [1,2]. In December 2019, a population of patients with pneumonia of unknown etiology was found in Wuhan, China. Many of the first patients were associated with a local seafood shop and live wild animals [1]. Therefore, it was initially thought that the disease was transmitted from animal to human. But after closing the said shop, the number of infected cases increased and it seemed that the second method of transmission of this disease was human-to-human [3]. PubDate: 12 Jan, 2022
Abstract: The social significance of public health and current scientific practice poses new responsibilities that drive scientific-medical societies to assume a public commitment, freely adopted and voluntary responsibility expressed through a Code of Good Practices [1], PubDate: 11 Oct, 2022
Abstract: Objectives: The aim of this study was to evaluate the effects of a global health promotion intervention in the workplace on cardiovascular risk factors and weight-related outcomes in offices workers after two years. Methods: This nonrandomized retrospective observational study analyzed data of two medical check-up of 728 office workers, over 40 years old: intervention group (376) and control (352) at baseline and after 2 years of a global health promotion program (based on nutrition, physical activity, and mental health) of mixed approach (individual, group and organizational) in the workplace of the intervention group. Results: Systolic and diastolic blood pressure experienced a statistically significant decrease (p ˂ 0.05) at 2 years of -0.94 mm Hg and -0.79 mm Hg in the intervention group versus the control group whose changes were + 0.02 mm Hg and -0.38 mm Hg. Glucose also decreased 1.59 mg/dl more in the intervention group. Lipids, smoking, body mass index or waist circumference did not undergo relevant modifications. Conclusion: This program improved blood pressure and glucose of office workers after two year follow-up, even among employees with low cardiovascular risk. However, according to the findings, this intervention was not as effective as expected in improving weight-related outcomes and cardiovascular risk in an office worker population. Companies should strengthen, not only an overall health intervention, but also individual and personalized advice in the fight against cardiovascular risk. PubDate: 11 Oct, 2022
Abstract: The Industrial Revolution has caused increasing amounts of pollution in the environment that has exposed the global population to various agents called environmental contaminants or pollutants, which are toxic metals, as well as smoking or radiation, and may cause epigenetic modifications related to health outcomes in the later stages of life, including cancer, heart disease, kidney disease, and neurological conditions, that may be influenced by epigenetic mechanisms triggered in intrauterine and neonatal life. PubDate: 11 May, 2022
Abstract: Introduction: Aging is a natural process but at the same time, the aging population has substantially increased. Socially this stage is considered the total of one lived experience. Materials and methods: The sample size has been 200 which is 100 in each group. Individuals beyond 60 years of age and who will be able to cooperate with the study were included in the study. World Health Organization oral health assessment form (2013) was used to record the oral health status of the subjects. The data were entered into an excel sheet and transferred to SPSS V. 21. for statistical analysis and Chi-square and ANOVA tests were done. Results: On assessment, 83 percent of old-age home residents and 68 percent from the family group did not have a periodontal pocket. Nonetheless, 12 percent of the individuals in a care home and 31% of the subjects in the family setting had pocket depths of 4-5 mm, while 1% of both groups had pocket depths of 6 mm. In comparison among elderly within the family set up and old age, homes reported a statistically significant difference between the 2 groups (p < 0.001) Conclusion: The findings of this study revealed that the institutionalized geriatric population suffers from a wide range of dental illnesses, the most frequent of which is dental caries. For the same, many of them require extensive treatment. PubDate: 09 Jun, 2022
Abstract: Although research about adult Attention Deficit Hyperactivity Disorder (adult ADHD) has become more prevalent since the condition’s recognition in the 1990s, information remains scarce about if and how its psychiatric comorbidities may compound impact on functionality in relationships. Studies abound on the independent effects on relationships of two of adult ADHD’s most common comorbidities - mood and substance use disorders. However, adults with ADHD sans comorbidities often experience interpersonal relationship difficulties due to the disorder’s signature symptoms alone - hyperactivity, impulsivity, and inattentiveness - as well as due to adult ADHD’s oft-observed dimension of emotional lability. The primary purpose of this study is to review the literature regarding the impact on intimate relationships of adult ADHD, as well as look at the potential compounding effects of comorbid mood or substance use disorder. The secondary purpose of this paper is to examine the literature on integrative therapy to treat couples wherein at least one partner struggles with adult ADHD, with or without comorbidities. Future research and practice implications are also discussed, including the hope for focus on the positive aspects of ADHD for individuals and relationships. PubDate: 08 Jul, 2022
Abstract: Introduction: The new-easily-fast-spreading-variant of SARS-CoV-2, B.1.1.529, is designated as a ‘Variant-of-Concern (VOC)’, the ‘Omicron’, now-suddenly-rise-of-more-transmissible-surprising-form, the “Sister”, causing detrimental-COVID-19 that impacts on public health, especially breakthrough severity-of-illness due-to-reinfections-or-infections in fully-vaccinated-people, causing more-severe-illness-or-death than other-variants also. And the COVID-scientists are trying the actual reasons regarding the quick speedy transmission of the variant, intensity, and ability to evade vaccines. So, it will require COVID-vaccine-booster-doses to tackle the ‘Omicron’ as early-as-possible, and the main objectives of the present study are to find out the most suitable ‘Preventive-Immunity-Booster-Community-Biomedicines-Vaccine (PIBCBV)’. Methods: The mixing of fresh weeds-vegetables-fruits-spices-(WVFS); amaranth-okra-cowpea-cucumber-ginger-turmeric-(AOCCGT)@(10g+25g+25g+35g+4g+1g=100g) respectively are prepared the 100g (a cup) of fresh-biomedicines-booster-meal-(BMBM)/ candidate (one-year to ninety-nine years-age-groups), taking-orally-in-different-forms @ twice-or-thrice/day (with any-kinds-of-nutritious-food) against naturally-occurring-coronavirus-2 infections-or-reinfections 45-days before COVID-19-infections, and in case-of-treatment, the dose may be increased depending on the intensity-of-diseases.Results: The present-Booster-Combination-(BC) of Weeds-Vegetables-Fruits-Spices-(WVFS), the Biomedicines-Booster-Meals-(BMBM) have revealed-again that Preventive-Booster-Community-Biomedicines (PBCBM), are very-much-effective in controlling-diseases-by-boosting-natural-immunity-against coronavirus-2 with no side effects among the student’s community. Conclusions: The Booster-Combination-(BC) of only-100g-Weeds-Vegetables-Fruits-Spices-(WVFS), the most cost-effective eco-friendly easily-manufacture-able easily-applicable easily-available, and side-effects-free ‘Biomedicines-Meals (BMM)’ not-only-serve as the ‘Natural-Gift’: “Potential-Preventive-Immunity-Booster-Community-Vaccine (PPIBCV) Against Omicron” enriching “Global-Public-Health-Forestry-Agriculture-Environment-Biodiversity-Wildlife-Conservation-Medical-Research-Science-Technology-Communication-Applications (GPHFAEBWCMRSTCA)” but also it acts-as-the “Nature’s-Gift to Human-Disease-Free-Global-Healthy-New-Normal-Life” OR fulfill the “Vaccine-Nationalism-to-Vaccine-Equity-and-Vaccine-Passport”. And in near future, it may be used mainly on “Public-Health-Epidemiology, Infectious-Diseases, and Pharmacology, Toxicology, Clinical-immunology, Clinical, and Bio-Medical-Education, and Pharmaceutical-Research also by developing different-forms-vaccines; ultra-high-diluted, steam-inhalation-therapy, etc., against ‘Omicron-Deltacron-Rupacrone-Bodhicrone-Radhacrone-Futuracrone- like any-‘Sister’-variant’ OR ‘Future-X-Disease’ which easily-prepare and distribute-enough-vaccines to immunize the world’s-population, and opening-a-path for the ‘Future-X-Epidemic also’ because-only-boosters-can-improve-immunity. PubDate: 08 Feb, 2022
Abstract: Background: Epidermolysis Bullosa (EB) is a heterogeneous genetic disorder with skin fragility. Only a few cases have been reported in Thailand. This study aims to determine the clinical characteristics, complications, and outcomes of EB stratified by subtype.Methods: A retrospective single-center study of EB patients at the Dermatology Unit, Queen Sirikit National Institute of Child Health, was reviewed from January 1, 2002, to December 31, 2021. Diagnosis is based on clinical manifestations and some skin biopsies.Results: There were 38 enrolled patients, age range from 0 to 25 years with a male-to-female ratio of 1.1:1. Family history of EB and consanguineous marriage were found in 6 cases and 2 cases, respectively. The most common type of EB was dystrophic EB (DEB) (26 cases) (68.4%), including recessive DEB in 15 cases (39.5%) and dominant DEB in 11 cases (28.9%). Other types were EB simplex in 10 cases (26.3%) and junctional EB in 2 cases (5.3%). Common complications were cutaneous bacterial infection (39.5%), anemia (31.6%), failure to thrive (18.4%), and protein energy malnutrition (15.8%). Musculoskeletal (21.1%), gastrointestinal (13.2%), and eye complications (7.9%) were exclusively found in DEB. Nineteen patients (50%) received regular follow-ups with a median duration of 9 months (range = 0.5 to 248 months). The mortality rate was 31.6% (6/19). Five cases died from bacterial sepsis, while one case died from metastatic squamous cell carcinoma.Conclusion: DEB is the most common type of EB in Thai children, and bacterial sepsis is the predominant cause of death. Further multicenter and molecular genetic studies are recommended for a definite diagnosis. PubDate: 05 Nov, 2022
Abstract: A review of the Countries with the highest coronavirus death rates in the world was made on February 11, 2022. The world’s average death rate that day was 746. It was not surprising to see the countries with the largest number of deaths having death rates 300- 400% of the world’s average. What was alarming was that the ten countries with the world’s highest death rates had death rates 400-800% of the world’s average and most of them were located in East-Central Europe. This paper focuses on understanding the implications of this. PubDate: 04 Mar, 2022
Abstract: UNESCO recommendation on science and scientific researchers aims to support scientific research and science as tools for achievements of the 17 sustainable development goals (SDGs). Countries are responded differently to these recommendations. In this article we tried to assess the polices and measures taken by Libya State as a developing country to meet these recommendations. The assessment reveals big shortcomings in the Libyan government’s response to UNESCO recommendation on science and scientific researchers. PubDate: 04 Jan, 2022
Abstract: A primary Undifferentiated Pleomorphic Sarcoma (UPS) of the mesentery is a rare form of malignancy, most commonly usually affecting the soft tissues of the extremities. Due to their location in the abdominal cavity distant from the intestinal loops they remain asymptomatic for a long time. In this study, an incidental finding on imaging is presented in a 66-year-old woman. CT imaging revealed a large mass in her abdomen, with difficulty pinpointing its exact origin. Exploratory laparotomy was performed to remove the mass in its entirety. Examination of the mass showed findings consistent with an undifferentiated pleomorphic sarcoma. She recovered well after her surgery. However, on follow-up imaging, a solitary metastatic lesion in her lung was detected. The prognosis of UPS is historically dismal with invasive treatment options currently being the preferred methods for management. PubDate: 02 Apr, 2022
Abstract: Digital health has come into reality, thanks to the new technologies such as Artificial Intelligence and Deep learning, contributing in a transcendental way to advances in the prevention, diagnosis, treatment and monitoring of diseases; In addition, this occurs at a crucial moment, marked by the growing prevalence of chronic diseases and the increase in life expectancy. In this context, digital health is not only necessary but, according to experts, it is the key to guaranteeing the present and future of quality healthcare. PubDate: 01 Oct, 2022
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