Subjects -> HEALTH AND SAFETY (Total: 1527 journals)
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HEALTH AND SAFETY (721 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 203 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 1)
ACM Transactions on Computing for Healthcare     Hybrid Journal  
Acta Informatica Medica     Open Access   (Followers: 2)
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Adultspan Journal     Hybrid Journal  
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11)
Advances in Public Health     Open Access   (Followers: 29)
Adversity and Resilience Science : Journal of Research and Practice     Hybrid Journal   (Followers: 2)
African Health Sciences     Open Access   (Followers: 6)
African Journal of Health Professions Education     Open Access   (Followers: 5)
Afrimedic Journal     Open Access   (Followers: 3)
Ageing & Society     Hybrid Journal   (Followers: 38)
Aging and Health Research     Open Access   (Followers: 6)
Air Quality, Atmosphere & Health     Hybrid Journal   (Followers: 8)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 2)
Akademika     Open Access  
American Journal of Family Therapy     Hybrid Journal   (Followers: 6)
American Journal of Health Economics     Full-text available via subscription   (Followers: 18)
American Journal of Health Education     Hybrid Journal   (Followers: 35)
American Journal of Health Sciences     Open Access   (Followers: 11)
American Journal of Health Studies     Full-text available via subscription   (Followers: 13)
American Journal of Preventive Medicine     Hybrid Journal   (Followers: 32)
American Journal of Public Health     Full-text available via subscription   (Followers: 187)
American Journal of Public Health Research     Open Access   (Followers: 30)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 8)
Annales des Sciences de la Santé     Open Access  
Annali dell'Istituto Superiore di Sanità     Open Access  
Annals of Clinical Medicine and Public Health     Open Access   (Followers: 11)
Annals of Global Health     Open Access   (Followers: 11)
Annals of Health Law     Open Access   (Followers: 6)
Applied Ergonomics     Hybrid Journal   (Followers: 17)
Apuntes Universitarios     Open Access   (Followers: 1)
Archives of Community Medicine and Public Health     Open Access   (Followers: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Suicide Research     Hybrid Journal   (Followers: 9)
Archivos de Prevención de Riesgos Laborales     Open Access  
Arquivos de Ciências da Saúde     Open Access  
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 7)
Asia Pacific Journal of Health Management     Full-text available via subscription   (Followers: 4)
Asian Journal of Gambling Issues and Public Health     Open Access   (Followers: 4)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Asian Journal of Social Health and Behavior     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access  
Australasian Journal of Paramedicine     Open Access   (Followers: 7)
Australian Advanced Aesthetics     Full-text available via subscription   (Followers: 4)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Indigenous HealthBulletin     Free   (Followers: 5)
Bijzijn XL     Hybrid Journal  
Biograph-I : Journal of Biostatistics and Demographic Dynamic     Open Access   (Followers: 4)
Biomedical Safety & Standards     Full-text available via subscription   (Followers: 7)
Biosafety and Health     Open Access  
Biosalud     Open Access  
Birat Journal of Health Sciences     Open Access  
BLDE University Journal of Health Sciences     Open Access  
BMC Oral Health     Open Access   (Followers: 5)
BMC Pregnancy and Childbirth     Open Access   (Followers: 20)
Brazilian Journal of Medicine and Human Health     Open Access  
British Journal of Health Psychology     Hybrid Journal   (Followers: 48)
Buletin Penelitian Kesehatan     Open Access  
Buletin Penelitian Sistem Kesehatan     Open Access  
Bulletin of the World Health Organization     Open Access   (Followers: 21)
Cadernos de Educação, Saúde e Fisioterapia     Open Access  
Cadernos de Saúde     Open Access  
Cambridge Quarterly of Healthcare Ethics     Hybrid Journal   (Followers: 14)
Canadian Family Physician     Partially Free   (Followers: 12)
Canadian Journal of Community Mental Health     Full-text available via subscription   (Followers: 13)
Canadian Journal of Human Sexuality     Hybrid Journal   (Followers: 1)
Canadian Journal of Public Health     Hybrid Journal   (Followers: 25)
Cannabis and Cannabinoid Research     Hybrid Journal   (Followers: 1)
Carta Comunitaria     Open Access  
Case Reports in Women's Health     Open Access   (Followers: 4)
CASUS : Revista de Investigación y Casos en Salud     Open Access  
Central Asian Journal of Global Health     Open Access   (Followers: 2)
CES Medicina     Open Access  
CES Salud Pública     Open Access  
Child and Adolescent Obesity     Open Access   (Followers: 3)
Child's Nervous System     Hybrid Journal  
Chinese Journal of Physiology     Open Access  
CHRISMED Journal of Health and Research     Open Access   (Followers: 1)
Christian Journal for Global Health     Open Access   (Followers: 1)
Ciencia & Salud     Open Access  
Ciencia & Trabajo     Open Access  
Ciencia e Innovación en Salud     Open Access  
Ciencia y Cuidado     Open Access   (Followers: 1)
Ciencia y Salud     Open Access   (Followers: 1)
Ciencia y Salud Virtual     Open Access  
Ciencia, Tecnología y Salud     Open Access  
Cities & Health     Hybrid Journal   (Followers: 4)
Cleaner and Responsible Consumption     Open Access   (Followers: 4)
Clinical and Experimental Health Sciences     Open Access   (Followers: 1)
ClinicoEconomics and Outcomes Research     Open Access   (Followers: 1)
CME     Hybrid Journal   (Followers: 1)
Community Health     Open Access   (Followers: 5)
Conflict and Health     Open Access   (Followers: 8)
Contraception and Reproductive Medicine     Open Access   (Followers: 1)
Cuaderno de investigaciones: semilleros andina     Open Access  
Cuadernos de la Escuela de Salud Pública     Open Access  
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 10)
Current Opinion in Environmental Science & Health     Hybrid Journal  
D Y Patil Journal of Health Sciences     Open Access  
Das österreichische Gesundheitswesen ÖKZ     Hybrid Journal  
Day Surgery Australia     Full-text available via subscription   (Followers: 2)
Design for Health     Hybrid Journal  
Disaster Medicine and Public Health Preparedness     Hybrid Journal   (Followers: 12)
Diversity and Equality in Health and Care     Open Access   (Followers: 9)
Diversity of Research in Health Journal     Open Access  
Dramatherapy     Hybrid Journal   (Followers: 2)
Drogues, santé et société     Open Access   (Followers: 2)
Duazary     Open Access  
Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / Journal of Duzce University Health Sciences Institute     Open Access  
Early Childhood Research Quarterly     Hybrid Journal   (Followers: 22)
East African Journal of Public Health     Full-text available via subscription   (Followers: 3)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 23)
EcoHealth     Hybrid Journal   (Followers: 4)
Education for Health     Open Access   (Followers: 8)
ElectronicHealthcare     Full-text available via subscription   (Followers: 2)
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 4)
Ensaios e Ciência : Ciências Biológicas, Agrárias e da Saúde     Open Access  
Environmental Disease     Open Access   (Followers: 3)
Environmental Sciences Europe     Open Access   (Followers: 2)
Epidemics     Open Access   (Followers: 6)
EsSEX : Revista Científica     Open Access  
Estudios sociales : Revista de alimentación contemporánea y desarrollo regional     Open Access  
Ethics & Human Research     Hybrid Journal   (Followers: 4)
Ethics, Medicine and Public Health     Full-text available via subscription   (Followers: 6)
Ethiopian Journal of Health Development     Open Access   (Followers: 7)
Ethiopian Journal of Health Sciences     Open Access   (Followers: 6)
Ethnicity & Health     Hybrid Journal   (Followers: 15)
Eurasian Journal of Health Technology Assessment     Open Access  
EUREKA : Health Sciences     Open Access  
European Journal of Health Communication     Open Access   (Followers: 4)
European Journal of Investigation in Health, Psychology and Education     Open Access   (Followers: 5)
Evidência - Ciência e Biotecnologia - Interdisciplinar     Open Access  
Exploratory Research in Clinical and Social Pharmacy     Open Access   (Followers: 4)
Expressa Extensão     Open Access  
F&S Reports     Open Access  
Face à face     Open Access  
Families, Systems, & Health     Full-text available via subscription   (Followers: 8)
Family & Community Health     Hybrid Journal   (Followers: 13)
Family Medicine and Community Health     Open Access   (Followers: 8)
Family Relations     Partially Free   (Followers: 11)
FASEB BioAdvances     Open Access  
Fatigue : Biomedicine, Health & Behavior     Hybrid Journal   (Followers: 2)
Finnish Journal of eHealth and eWelfare : Finjehew     Open Access  
Food and Public Health     Open Access   (Followers: 11)
Food Hydrocolloids for Health     Open Access   (Followers: 5)
Food Quality and Safety     Open Access   (Followers: 2)
Frontiers in Digital Health     Open Access   (Followers: 4)
Frontiers in Neuroergonomics     Open Access  
Frontiers in Public Health     Open Access   (Followers: 7)
Frontiers of Health Services Management     Partially Free   (Followers: 6)
Gaceta Sanitaria     Open Access   (Followers: 2)
Galen Medical Journal     Open Access  
Ganesha Journal     Open Access  
Gazi Sağlık Bilimleri Dergisi     Open Access  
Geospatial Health     Open Access   (Followers: 1)
Gestão e Desenvolvimento     Open Access  
Gesundheitsökonomie & Qualitätsmanagement     Hybrid Journal   (Followers: 8)
Giornale Italiano di Health Technology Assessment     Full-text available via subscription  
Global Challenges     Open Access  
Global Health : Science and Practice     Open Access   (Followers: 7)
Global Health Annual Review     Open Access   (Followers: 2)
Global Health Journal     Open Access   (Followers: 2)
Global Journal of Health Science     Open Access   (Followers: 5)
Global Journal of Public Health     Open Access   (Followers: 15)
Global Medical & Health Communication     Open Access   (Followers: 1)
Global Mental Health     Open Access   (Followers: 9)
Global Reproductive Health     Open Access  
Global Security : Health, Science and Policy     Open Access  
Global Transitions     Open Access  
Global Transitions Proceedings     Open Access   (Followers: 5)
Globalization and Health     Open Access   (Followers: 7)
Hacia la Promoción de la Salud     Open Access  
Hastane Öncesi Dergisi     Open Access  
Hastings Center Report     Hybrid Journal   (Followers: 7)
HCU Journal     Open Access  
HEADline     Hybrid Journal  
Health & Place     Hybrid Journal   (Followers: 19)
Health & Justice     Open Access   (Followers: 5)
Health and Human Rights     Open Access   (Followers: 9)
Health and Research Journal     Open Access  
Health and Social Care Chaplaincy     Hybrid Journal   (Followers: 10)
Health and Social Work     Hybrid Journal   (Followers: 62)
Health Behavior and Policy Review     Full-text available via subscription   (Followers: 5)
Health Behavior Research     Open Access   (Followers: 2)
Health Care Analysis     Hybrid Journal   (Followers: 13)
Health Equity     Open Access   (Followers: 2)
Health Information : Jurnal Penelitian     Open Access  
Health Notions     Open Access  
Health Policy     Hybrid Journal   (Followers: 44)
Health Policy and Technology     Hybrid Journal   (Followers: 5)
Health Policy OPEN     Open Access  
Health Promotion International     Hybrid Journal   (Followers: 23)
Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals     Full-text available via subscription   (Followers: 7)
Health Prospect     Open Access  
Health Psychology     Full-text available via subscription   (Followers: 56)
Health Psychology Bulletin     Open Access   (Followers: 1)
Health Psychology Research     Open Access   (Followers: 21)
Health Psychology Review     Hybrid Journal   (Followers: 46)

        1 2 3 4 | Last

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Journal Cover
Global Medical & Health Communication
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2301-9123 - ISSN (Online) 2460-5441
Published by Universitas Islam Bandung Homepage  [3 journals]
  • Clinical Characteristics, Comorbidities, Length of Stay, and Mortality of
           COVID-19 Patients in RSUD Cideres, Majalengka, West Java

    • Authors: Herry Garna; Dika Rifky Fernanda, Gibran Bramasta Dirgavansya, Heru Haerudin, Zulmansyah Zulmansyah, Samsudin Surialaga, Lelly Yuniarti
      Abstract: Until now, the world is still facing the COVID-19 pandemic caused by SARS-CoV-2. The number of deaths of COVID-19 patients in Indonesia is quite large when compared to other countries. Clinical manifestations, comorbidities, length of stay, and the mortality of COVID-19 vary widely in each study. This study analyzes clinical characteristics, comorbidities, length of stay, and mortality of COVID-19 patients in RSUD Cideres, Majalengka, West Java. This study is an observational study with total sampling and purposive sampling. Subjects were patients with nasal swabs confirmed SARS-CoV-2 and hospitalized at RSUD Cideres from January to July 2021. Clinical manifestations, comorbidities, length of stay, and mortality of COVID-19 patients aged ≥17 years old, were extracted from medical records. Results showed that the majority of 213 COVID-19 patients were age 41–60 years 114 (53.5%), female 114 (53.5%), with an upper respiratory tract in 207 (97.1%), and shortness of breath in 203 (95.3%) patients. 153 (71.8%) patients had a fever, while headache, diarrhea, and anosmia respectively 49 (23.0%), 19 (8.9%), and 10 (4.6%), respectively. Vital signs were the Glasgow Coma Scale (GCS) normal in 190 (89.2%) patients. Most of patients had respiration rate >20/min in 201 (94.3%), oxygen saturation <90% in 98 (46.0%), and chest x-rays: bronchopneumonia 134 (62.9%) and pneumonia 23 (10.7%). Comorbidities were hypertension, diabetes mellitus, and chronic heart failure in 74 (34.7%), 56 (26.2%), and 46 (11.7%) patients, respectively. The length of stay who died for 1–7 days (22 patients) and 8–14 days (9 patients); means almost all patients (29 of 32) died during the length of stay for 1–14 days. In conclusion, the majority of COVID-19 patients at RSUD Cideres are female, aged 41–60 years, had upper respiratory tract/shortness of breath, GCS normal, saturation oxygen <90%, chest x-rays: bronchopneumonia and pneumonia, comorbidities: hypertension, and length of stay for patients who died 1–7 days. KARAKTERISTIK KLINIS, KOMORBITAS, LAMA RAWAT, DAN MORTALITAS PASIEN COVID-19 DI RSUD CIDERES, MAJALENGKA, JAWA BARATHingga saat ini, dunia masih menghadapi pandemi COVID-19 yang disebabkan oleh SARS-CoV-2. Jumlah kematian pasien COVID-19 di Indonesia cukup besar jika dibanding dengan negara lain. Manifestasi  klinis, komorbid, lama rawat, dan mortalitas pasien COVID-19 sangat bervariasi pada setiap penelitian. Tujuan penelitian ini menganalisis karakteristik klinis, komorbiditas, lama rawat, dan mortalitas pasien COVID-19 di RSUD Cideres, Majalengka, Jawa Barat. Penelitian ini adalah penelitian observasional dengan total sampling dan purposive sampling. Subjek adalah pasien dengan nasal swab terkonfirmasi SARS-CoV-2 dan dirawat di RSUD Cideres periode Januari hingga Juli 2021. Data manifestasi klinis, komorbid, lama rawat, dan mortalitas pasien COVID-19 usia ≥17 diambil dari rekam medik. Hasil menunjukkan bahwa mayoritas 213 pasien COVID-19 berusia 41–60 tahun 114 (53,5%) dan wanita 114 (53,5%) dengan keluhan saluran napas atas 207 (97,1%) dan napas pendek 203 (95,3%) pasien. 153 (71,8%) pasien mengalami demam, sedangkan sakit kepala, diare, dan anosmia masing-masing 49 (23,0%), 19 (8,9%), dan 10 (4,6%) pasien. Tanda vital Glasgow Coma Scale (GCS) normal pada 190 (89,2%) pasien. Kebanyakan pasien mempunyai frekuensi napas >20/menit pada 201 (94,3%) pasien, saturasi oksigen <90% pada 98 (46,0%) pasien, serta rontgen toraks: bronkopneumonia pada 134 (62,9%) pasien dan pneumonia pada 23 (10,7%) pasien. Komorbid adalah hipertensi, diabetes melitus, dan chronic heart failure pada 74 (34,7%), 56 (26,2%), dan 46 (11,7%) pasien berturut-turut. Lama rawat pasien yang meninggal 1–7 hari (22 pasien) dan 8–14 hari (9 pasien), berarti hampir semua pasien (29 dari 32) meninggal selama rawat 1–14 hari. Simpulan, mayoritas pasien COVID-19 di RSUD Cideres adalah wanita, berusia 41–60 tahun, keluhan saluran napas atas/napas pendek, GCS normal, rontgen toraks: bronkopneumonia dan pneumonia, komorbid: hipertensi, serta lama rawat pasien yang meninggal paling banyak 1–7 hari.
      PubDate: Fri, 31 Dec 2021 23:30:57 +070
  • Relationship between Pain and Serum Ferritin Levels in Adult
           Transfusion-dependent Thalassemia

    • Authors: Shenny Dianathasari Santoso; Uni Gamayani, Asep Nugraha Hermawan, Pandji Irani Fianza, Aih Cahyani, Lisda Amalia, Yusuf Wibisono, Ramdan Panigoro
      Abstract: Patients with transfusion-dependent thalassemia (TDT) may experience an increase in ferritin due to shorter erythrocyte lifespan and lysis, as well as side effects of transfusion. Increasing ferritin can cause various complications, including pain, which can develop into chronic pain and interfere with life quality. This study aims to determine the relationship between pain and serum ferritin levels in adults with TDT. This study was an analytical observational study using a cross-sectional design on adult TDT patients with pain who came to the Hemato-Oncology Polyclinic of Dr. Hasan Sadikin Bandung General Hospital Bandung. This research was conducted from March to June 2021. All subjects were assisted to fill out the Indonesian version of the Brief Pain Inventory Short Form (BPI-SF) questionnaire before transfusion. Ferritin levels in the last three months were obtained from medical records. If more than three months, serum ferritin levels were examined. Ferritin levels and BPI-SF scores were then correlated using the Pearson test. The study was conducted on 51 adult TDT patients with pain, and the average value of ferritin levels in research subjects is 5081±2929 g/L. There was a relationship between pain (the dimensions of pain interfere with life on the BPI-SF score) and an increase in ferritin levels (p=0.042, r=0.29). The results showed there is a relationship between pain and serum ferritin levels. Regular consumption of iron chelation tablets can reduce ferritin levels and improve the quality of life for adults with TDT. HUBUNGAN NYERI DENGAN KADAR FERITIN SERUM PADA PENYANDANG TRANSFUSION-DEPENDENT THALASSEMIA DEWASAPenyandang transfusion-dependent thalassemia (TDT) dapat mengalami peningkatan feritin akibat umur eritrosit yang lebih pendek dan mudah lisis, serta efek samping terhadap pemberian transfusi. Peningkatan feritin tersebut dapat menyebabkan berbagai komplikasi di antaranya nyeri yang dapat berkembang menjadi nyeri kronik dan mengganggu kualitas hidup. Penelitian ini bertujuan mengetahui hubungan nyeri dengan kadar feritin serum pada penyandang TDT dewasa. Penelitian dengan observasional analitik menggunakan rancangan potong lintang pada penyandang TDT dewasa dengan nyeri yang datang ke Poliklinik Hemato-Onkologi RSUP Dr. Hasan Sadikin Bandung. Penelitian dilakukan dari Maret hingga Juni 2021. Seluruh subjek dilakukan pendampingan untuk mengisi kuesioner Brief Pain Inventory Short Form (BPI-SF) versi Indonesia sebelum transfusi. Kadar feritin dalam tiga bulan terakhir didapatkan dari rekam medis dan bila lebih dari tiga bulan dilakukan pemeriksaan kadar feritin serum. Kadar feritin dan skor BPI-SF kemudian dikorelasikan menggunakan Uji Pearson. Penelitian dilakukan kepada 51 penyandang TDT dewasa dengan gejala nyeri dan didapatkan nilai rerata kadar feritin pada subjek penelitian adalah 5081±2929 μg/L. Hasil penelitian memperlihatkan terdapat hubungan antara nyeri (dimensi efek nyeri terhadap kehidupan) dan peningkatan kadar feritin (p=0,042; r=0,29). Simpulan, terdapat hubungan antara nyeri dan kadar feritin serum. Konsumsi tablet kelasi besi secara rutin dapat menurunkan kadar feritin dan memperbaiki kualitas hidup penyandang TDT dewasa.
      PubDate: Fri, 31 Dec 2021 23:30:45 +070
  • The Role of Perceived Social and Spiritual Support and Depression to
           Health-related Quality of Life on Patients with SLE

    • Authors: Suci Nugraha; Elizabeth Kristi Poerwandari, Dharmayati Utoyo Lubis
      Abstract: Belief in the availability of social support (perceived social support) was known to influence depression and health-related quality of life in SLE patients. This support becomes a psychological resource when they experience negative emotional states such as depression caused by a chronic illness such as SLE. In people whose lives are influenced by religion, such as in Indonesian culture, belief in God's help (perceived spiritual support) is an important variable that needs to be studied because it is predicted to affect patients’ health-related quality of life. This study aims to explain the relationship between perceived social support, spiritual support, and depression to health-related quality of life in a patient with SLE. This cross-sectional study was conducted from March to June 2021 towards 328 SLE patients selected using the convenient sampling technique. Data was collected through forms that are distributed online and offline. The research sample was SLE patients who were members of a lupus community in Indonesia and lived in several cities in Java. The statistical analysis using a structural model (CMIN/df=103, RMSEA=0.103, CFI=0.972, TLI=0.963). Chi-square value=201,835 (p=0.000) suggested that perceived social support directly affected the level of depression and health-related quality of life on a patient with SLE, while perceived spiritual support affected the health-related quality of life through the mediation of depression, which means that spiritual support affected the quality of life by reducing negative emotions experienced by SLE patients. PERAN DUKUNGAN SOSIAL, SPIRITUAL, DAN DEPRESI TERHADAP KUALITAS HIDUP TERKAIT KESEHATAN PASIEN SLEKeyakinan akan ketersediaan dukungan sosial (perceived social support) diketahui memengaruhi depresi dan kualitas hidup terkait kesehatan pada pasien SLE. Dukungan ini diyakini menjadi sumber daya psikologis saat individu berada dalam kondisi emosi yang negatif seperti depresi yang disebabkan oleh penyakit kronis seperti SLE. Pada masyarakat yang kehidupannya dipengaruhi oleh agama seperti di Indonesia, keyakinan akan pertolongan Tuhan (perceived spiritual support) merupakan variabel penting yang perlu dipelajari karena diprediksi memengaruhi kualitas hidup terkait kesehatan. Penelitian ini bertujuan menjelaskan mekanisme hubungan antara perceived social support, spiritual support, dan depresi terhadap kualitas hidup terkait kesehatan pasien SLE. Penelitian cross-sectional ini dilakukan dari Maret hingga Juni 2021 pada 328 pasien SLE yang dipilih dengan convinient sampling technique. Data dikumpulkan melalui formulir yang disebarkan secara daring dan luring. Sampel penelitian merupakan pasien SLE yang tergabung dalam suatu komunitas lupus dan berdomisili di beberapa kota di pulau Jawa. Hasil analisis statistik dengan model struktural (CMIN/df=103; RMSEA=0,103; CFI=0,972; TLI=0.963). Nilai chi-square=201.835 (p=0,000) memperlihatkan bahwa perceived social support berpengaruh secara langsung pada tingkat depresi dan kualitas hidup pasien SLE. Sementara itu, perceived spiritual support memengaruhi kualitas hidup terkait kesehatan melalui mediasi depresi yang berarti bahwa spiritual support memengaruhi kualitas hidup dengan mengurangi kondisi emosi negatif yang dirasakan oleh pasien SLE.
      PubDate: Fri, 31 Dec 2021 23:30:37 +070
  • Relationship between Tension-type Headache and Quality of Sleep, Excessive
           Daytime Sleepiness, and Fatigue Syndrome among Healthcare Workers during

    • Authors: Pepi Budianto; Stefanus Erdana Putra, Muhammad Hafizhan, Fauzi Novia Isnaening Tyas, Astrida Fesky Febrianty, Hanindia Riani Prabaningtyas, Diah Kurnia Mirawati, Rivan Danuaji, Subandi Subandi
      Abstract: Coronavirus disease 2019 (COVID-19) is an infectious disease that was later declared a pandemic. During a pandemic, excessive workloads cause an increase in physical symptoms, such as tension-type headaches, in medical personnel. Tension-type headache (TTH) is associated with decreased sleep quality which will lead to excessive daytime sleepiness (EDS) and fatigue syndrome. This study aims to determine the relationship between TTH and sleep quality, EDS, and fatigue syndrome in medical personnel during the pandemic. This study is a cross-sectional study conducted on health workers at Sebelas Maret University Hospital, Surakarta, Indonesia in March–August 2020. The relationship between TTH and three other variables was analyzed using the Spearman correlation test. Multiple logistic regression analysis was used to calculate the odds ratio (OR) of headache associated with the covariate. The Kruskal-Wallis test was used to compare sleep quality, EDS, and fatigue syndrome in the TTH, non-TTH headache, and control groups. There were 120 respondents (mean age 30.93±12.48) in this study. The Spearman correlation test found a weak positive correlation between TTH and the three dependent variables. OR sleep quality, EDS, and fatigue syndrome with the incidence of TTH respectively 2.33 (95% CI=1.18–5.11, p<0.001); 2.52 (CI 95%=1.17–4.79, p=0.001), and 4.46 (95% CI=2.71–7.69, p<0.001). The Kruskal-Wallis test showed that the TTH group had poorer sleep quality and more frequent EDS and fatigue syndrome. There is a significant relationship between TTH and sleep quality, EDS, and fatigue syndrome in medical personnel during the pandemic. HUBUNGAN NYERI KEPALA TIPE TEGANG DENGAN KUALITAS TIDUR, RASA KANTUK BERLEBIHAN DI SIANG HARI, DAN SINDROM KELELAHAN PADA TENAGA MEDIS SELAMA COVID-19Coronavirus disease 2019 (COVID-19) merupakan penyakit menular yang kemudian dinyatakan sebagai pandemi. Selama pandemi, beban kerja yang berlebihan menyebabkan peningkatan gejala fisik, seperti nyeri kepala tipe tegang (tension-type headache) pada tenaga medis. Tension-type headache (TTH) dikaitkan dengan penurunan kualitas tidur yang akan menyebabkan rasa kantuk berlebihan di siang hari (excessive daytime sleepiness, EDS) dan sindrom kelelahan. Penelitian ini bertujuan mengetahui hubungan TTH dengan kualitas tidur, EDS, dan sindrom kelelahan pada tenaga medis selama pandemi. Penelitian ini merupakan studi potong lintang yang dilakukan pada petugas kesehatan di RS Universitas Sebelas Maret, Surakarta, Indonesia pada Maret–Agustus 2020. Hubungan antara TTH dan tiga variabel lainnya dianalisis menggunakan uji korelasi Spearman. Analisis regresi logistik ganda digunakan untuk menghitung odds ratio (OR) nyeri kepala yang terkait dengan kovariat. Uji Kruskal-Wallis digunakan untuk membandingkan kualitas tidur, EDS, dan sindrom kelelahan pada kelompok TTH, nyeri kepala non-TTH, dan kontrol. Terdapat 120 responden (rerata usia 30,93±12,48). Uji korelasi Spearman menemukan korelasi positif lemah antara TTH dan tiga variabel terikat. OR kualitas tidur, EDS, dan sindrom kelelahan dengan kejadian TTH secara berurutan 2,33 (IK95%=1,18–5,11; p<0,001); 2,52 (IK95%=1,17–4,79; p=0,001); dan 4,46 (IK95%=2,71–7,69; p<0,001). Uji Kruskal-Wallis menunjukkan bahwa kelompok TTH memiliki kualitas tidur yang lebih buruk dan lebih sering mengalami EDS, serta sindrom kelelahan. Terdapat hubungan yang signifikan TTH dengan kualitas tidur, EDS, dan sindrom kelelahan pada tenaga medis selama pandemi.
      PubDate: Fri, 31 Dec 2021 23:30:27 +070
  • Neonatal Care Education during Pregnancy Using Videos on the iPosyandu

    • Authors: Fedri Ruluwedrata Rinawan; Ilma Dina Arrahmah, Didah Didah, Nelly Dameria Sinaga, Ari Indra Susanti, Rima Kusumah Dewi, Atriany Nilam Sari
      Abstract: Indonesia Demographic and Health Survey (IDHS) 2017 shows that the neonatal mortality rate (NMR) in Indonesia was 15 per 1,000 live births. A decrease in NMR to 12 per 1,000 live births can reduce the infant mortality rate (IMR). Purwakarta regency in 2019 ranked 14 out of 27 regencies and cities that contribute to the NMR in West Java. This research analyzes the knowledge of pregnant women about neonatal care before and after being given a combination of video animation and demonstration on the iPosyandu Parents application. The research method used was quantitative with one group pretest-posttest design, an interventional study without a control group. The sample size was 60 pregnant women in their third trimester. Samples that met the criteria were taken by purposive sampling technique and according to the midwife's instructions at the Pasawahan Public Health Center, Purwakarta regency. This research was conducted in May 2020. The knowledge data were collected using a questionnaire that was translated from previous studies. The questionnaire topic groups were adapted from the government's Maternal and Child Health book. The results showed differences in knowledge before and after being given health education using audiovisual media in 7 topic groups. They comprised general information on neonatal care, early breastfeeding initiation, breastfeeding, keeping babies warm, umbilical cord care, schedule of neonatal visits, and immunization. However, there was no difference in one topic group, namely the newborn danger critical signs.
      Angka kematian neonatus (AKN) menurut Survei Demografi dan Kesehatan Indonesia (SDKI) tahun 2017 di Indonesia adalah 15 per 1.000 lahir hidup. Penurunan AKN hingga 12 per 1.000 kelahiran hidup dapat menekan angka kematian bayi (AKB). Kabupaten Purwakarta pada tahun 2019 menempati urutan ke-14 dari 27 kabupaten dan kota penyumbang AKN di Jawa Barat. Tujuan penelitian ini menganalisis pengetahuan ibu hamil mengenai perawatan neonatus sebelum dan sesudah diberikan video kombinasi animasi dan demonstrasi pada aplikasi iPosyandu Orangtua. Metode penelitian yang digunakan adalah kuantitatif dengan desain one grup pretest-posttest yang merupakan penelitian intervensional tanpa kelompok kontrol. Besar sampel dalam penelitian ini adalah 60 ibu hamil trimester III. Sampel yang memenuhi kriteria diambil dengan teknik purposive sampling sesuai dengan arahan dari bidan Puskesmas Pasawahan Kabupaten Purwakarta. Penelitian ini dilakukan pada bulan Mei 2020. Pengumpulan data pengetahuan dilakukan dengan menggunakan kuesioner yang diterjemahkan dari penelitian sebelumnya. Kelompok topik kuesionernya disesuaikan dengan buku Kesehatan Ibu dan Anak (KIA) dari pemerintah. Hasil penelitian menunjukkan bahwa terdapat perbedaan pengetahuan sebelum dan sesudah diberikan pendidikan kesehatan menggunakan media audiovisual pada 7 kelompok topik. Topik tersebut terdiri atas informasi umum perawatan neonatus, inisiasi menyusui dini (IMD), pemberian ASI, menjaga bayi tetap hangat, perawatan tali pusat, jadwal kunjungan neonatal, dan imunisasi. Akan tetapi, kelompok mengenai tanda bahaya bayi baru lahir tidak terdapat perbedaan.
      PubDate: Fri, 31 Dec 2021 23:30:19 +070
  • The Increased Knowledge of Children Dental and Oral Health at the Baitus
           Syukur Orphanage in Bandung

    • Authors: Siska Nia Irasanti; Yuniarti Yuniarti, Yuli Susanti, Yani Dewi Suryani, Revika Ilma Nurul Uswah, Risya Farisatul Aini, Novita Arya Cahyani, Hilal Muhammad Dimas Nugraha, Muhammad Mufti
      Abstract: The COVID-19 pandemic has led to restrictions on visits to the dentist except for emergency cases. It causes the examination and treatment of dental and oral diseases to be hampered, which is feared to impact a person's overall health condition negatively. Therefore, each individual is expected to maintain optimal dental and oral health to prevent it. Until now, based on the results of interviews with the head of the Baitus Syukur orphanage, it was stated that the level of awareness of foster children on the importance of maintaining dental and oral health was low, and they did not yet have a special examination program related to dental and oral health. This study aims to analyze whether there is an increase in children's knowledge in the Baitus Syukur orphanage after counseling on oral health. This type of research is a quasi-experiment with pre and post-test methods in March–April 2021. This study uses a total population of 24 children in the Baitus Syukur orphanage. The data were analyzed with the results of the Wilcoxon Test analysis at a 95% confidence level. It showed that statistically, there was a significant difference between the values before and after giving counseling materials to participants with p value=0.003 (p value≤0.05). The conclusion is that there is an increase in children's knowledge about dental and oral health at the Baitus Syukur orphanage after counseling. PENINGKATAN PENGETAHUAN KESEHATAN GIGI DAN MULUT ANAK DI PANTI ASUHAN BAITUS SYUKUR BANDUNGKondisi pandemik COVID-19 menyebabkan pembatasan kunjungan ke dokter gigi kecuali untuk kasus penyakit kesehatan gigi dan mulut darurat. Hal ini menyebabkan pemeriksaan dan perawatan penyakit gigi dan mulut terhambat yang dikhawatirkan akan menimbulkan dampak negatif terhadap kondisi kesehatan seseorang secara menyeluruh. Untuk mencegah hal ini, setiap individu diharapkan dapat menjaga kesehatan gigi dan mulutnya secara optimal. Sampai saat ini, berdasar atas hasil wawancara dengan Ketua Panti Asuhan Baitus Syukur menyatakan bahwa tingkat kesadaran anak asuh dalam menjaga kesehatan gigi dan mulut rendah dan belum memiliki program pemeriksaan khusus terkait kesehatan gigi dan mulut. Penelitian ini bertujuan menganalisis apakah terdapat peningkatan pengetahuan anak di Panti Asuhan Baitus Syukur setelah dilakukan penyuluhan mengenai kesehatan gigi dan mulut. Jenis penelitian ini adalah eksperimen quasi dengan metode pre and post-test pada Maret–April 2021. Penelitian ini menggunakan total populasi anak di Panti Asuhan Baitus Syukur yang berjumlah 24 orang. Data dianalisis menggunakan Uji Wilcoxon pada derajat kepercayaan 95% menunjukkan bahwa secara statistik, terdapat perbedaan yang signifikan antara nilai sebelum dan setelah pemberian materi penyuluhan pada  partisipan dengan p=0,003 (p≤0,05). Simpulan, terdapat peningkatan pengetahuan  anak mengenai kesehatan gigi dan mulut di Panti Asuhan Baitus Syukur setelah dilakukan penyuluhan.
      PubDate: Fri, 31 Dec 2021 23:30:09 +070
  • Noviemeter Diagnostic Test as a Head Circumference Measurement Device for
           Under-Five Children

    • Authors: Ma’mun Sutisna; Achmad Suardi, Hidayat Wijayanegara, Leri Septiani, Herry Garna
      Abstract: The current typical practice for measuring the head circumference of under-five children is by using a measuring tape. However, it may create some difficulties as children cry and move during measurement, leading to less accurate results. Accurate head circumference measurement is essential for assessing brain development and early detection of brain development disorders. Therefore, a more accurate device to measure head circumference is needed. Noviemeter is a non-touch digitalized head circumference measuring device that enables easier measurement in under-five children. As a new tool, noviemeter’s accuracy, sensitivity, and specificity must be determined. This study aimed to analyze the difference in the head of under-five children circumference measurement results between a typical measuring tape as the gold standard and noviemeter and determine the accuracy, sensitivity, and specificity of the noviemeter. It was a cross-sectional analytical study using cluster random sampling on 72 under-five children in the work area of Guntung Payung Public Health, South Kalimantan, during August 2020. The measurement was performed twice, first using a measuring tape and, second, using a noviemeter. Data were analyzed statistically using the dependent t test and diagnostic test. No significant difference was found between the results of the two measuring devices (p=0.257). The sensitivity, specificity, and accuracy of the noviemeter were 87.0%, 88.4%, and 91.8%, respectively. Thus, noviemeter has good sensitivity, specificity, and accuracy as an easier alternative device to measure head circumference in under-five children. UJI DIAGNOSTIK NOVIEMETER SEBAGAI ALAT PENGUKUR LINGKAR KEPALA BALITAPraktik pengukuran lingkar kepala balita yang umum dilakukan saat ini adalah dengan menggunakan pita ukur. Akan tetapi, hal itu dapat menimbulkan beberapa kesulitan karena anak menangis dan bergerak selama pengukuran yang menyebabkan hasil yang kurang akurat. Pengukuran lingkar kepala yang akurat sangat penting untuk menilai perkembangan otak dan deteksi dini gangguan perkembangan otak. Oleh karena itu, diperlukan alat yang lebih akurat untuk mengukur lingkar kepala. Noviemeter merupakan alat pengukur lingkar kepala digital non-sentuh yang memungkinkan pengukuran lebih mudah pada anak balita. Sebagai alat baru, akurasi, sensitivitas, dan spesifisitas noviemeter harus ditentukan. Penelitian ini bertujuan menganalisis perbedaan hasil pengukuran lingkar kepala balita antara pita ukur tipikal sebagai baku emas dan noviemeter serta mengetahui akurasi, sensitivitas, dan spesifisitas dari noviemeter tersebut. Jenis penelitian ini adalah cross-sectional analytical dengan menggunakan cluster random sampling pada 72 balita di wilayah kerja Puskesmas Guntung Payung Kalimantan Selatan selama bulan Agustus 2020. Pengukuran dilakukan dua kali, pertama menggunakan pita pengukur dan kedua menggunakan noviemeter. Data dianalisis secara statistik menggunakan uji t dependen dan uji diagnostik. Tidak ditemukan perbedaan yang signifikan antara hasil kedua alat ukur (p=0,257). Sensitivitas, spesifisitas, dan akurasi noviemeter masing-masing adalah 87,0%; 88,4%; dan 91,8%. Dengan demikian, noviemeter memiliki sensitivitas, spesifisitas, dan akurasi yang baik sebagai alat alternatif yang lebih mudah untuk mengukur lingkar kepala pada anak balita.
      PubDate: Fri, 31 Dec 2021 00:00:00 +070
  • Effect of Nursing Dysphagia Screening Tool Education on Increasing
           Knowledge of Documentation for Screening Results in Hospital Nurses

    • Authors: Esther Palupi; Yuyun Yueniwati, Alfrina Hany
      Abstract: Efforts to prevent complications of dysphagia can be detected using a quick and correct screening method. Dysphagia screening tool (DST) can identify dysphagia stroke patients with eight indicators. Therefore, it makes it easier for nurses to improve their ability to document it. This study aims to analyze the effect of nursing dysphagia screening tool (NDST) education on increasing knowledge of screening documentation for hospital nurses. The research method was a quasi-experimental design with a non-equivalent control group. The research was taking place at Tk. II dr. Soepraoen Hospital Malang starting 14 July–23 July 2021. A sample of 120 nurses was selected with a total sampling of 60 controls and interventions. Bivariate data analysis applied dependent t test followed by Mann-Whitney. The results showed that the mean difference of knowledge value was −19.999 with t arithmetic of −8.373 and significance of 0.000<0.05. The significance value of the control group is 0.000<0.05, which means that there is a significant difference before and after the action on the knowledge variable of the NDST education control group through the website link. Asymp. Sig. value 0.000<0.05 means a difference between the increase in knowledge of the education treatment group through face-to-face lectures and the website link control group. In conclusion, there were knowledge differences in documenting the results of dysphagia screening on patients with stroke before and after DST learning. Suggestions for the hospital's management team were to review and apply the results of the study in the form of NDST learning socialization to screen for dysphagia on patients with stroke to optimize the prevention for stroke complications in the first 24 hours. PENGARUH EDUKASI NURSING DYSPHAGIA SCREENING TOOL TERHADAP PENINGKATAN PENGETAHUAN DOKUMENTASI HASIL SKRINING PADA PERAWAT RUMAH SAKITUpaya pencegahan komplikasi disfagia dapat dideteksi menggunakan metode skrining yang cepat dan benar. Dysphagia screening tool (DST) dapat mengidentifikasi disfagia pasien strok dengan delapan indikator. Hal ini mempermudah perawat untuk meningkatkan kemampuannya dalam mendokumentasikannya. Tujuan penelitian ini menganalisis pengaruh edukasi nursing dysphagia screening tool (NDST) terhadap peningkatan pengetahuan dokumentasi hasil skrining pada perawat rumah sakit. Metode penelitian yang digunakan adalah quasi-experimental design dengan  non-equivalent control group. Penelitian bertempat di RS Tk. II dr. Soepraoen Malang pada 14 Juli–23 Juli 2021. Sampel sebanyak 120 perawat dipilih secara total sampling, 60 kontrol dan perlakuan. Analisis data bivariat menggunakan uji t dependen dilanjutkan dengan Mann-Whitney. Hasil menunjukkan nilai mean difference pengetahuan sebesar −19,999 dengan t hitung sebesar −8,373 dan signifikansi 0,000<0,05. Nilai signifikansi kelompok kontrol 0,000<0,05 yang berarti terdapat perbedaan yang signifikan sebelum dan sesudah tindakan pada variabel pengetahuan kelompok kontrol edukasi NDST melalui tautan website. Nilai Asymp. Sig. 0,000<0,05 berarti terdapat perbedaan antara peningkatan pengetahuan kelompok perlakuan edukasi melalui ceramah tatap muka dan kelompok kontrol tautan website. Simpulan, terdapat perbedaan pengetahuan dalam pendokumentasian hasil skrining disfagia pasien strok di RS sebelum dan sesudah dilakukan edukasi NDST. Saran untuk tim manajerial rumah sakit dapat menelaah dan menerapkan hasil penelitian berupa sosialisasi edukasi NDST untuk menskrining disfagia pasien strok untuk mengoptimalikan pencegahan perburukan klinis komplikasi strok pada 24 jam pertama.
      PubDate: Fri, 31 Dec 2021 00:00:00 +070
  • Level of Depression, Anxiety, and Stress of College Students in Indonesia
           during the Pandemic COVID-19

    • Authors: Nurul Romadhona; Susan Fitriyana, Ganang Ibnusantosa, Titik Respati
      Abstract: The COVID-19 pandemic has caused a shift in learning methods to online. The obstacles felt by college students can have an impact on mental health. However, data on student mental health in Indonesia during the pandemic is still limited. This study describes the depression, anxiety, and stress of college students in Indonesia during the COVID-19 pandemic. This research method is descriptive, conducted on college students in Indonesia from July to August 2021. Sampling is done by voluntary sampling collection, with 258 respondents. The research instrument is a questionnaire of characteristics and depression, anxiety, stress scale (DASS) 42 in the form of Google Form. Data analysis using Microsoft Excel. The results of the research on the characteristics of the most respondents, namely, age in the range of 20–24 years (85.3%), female (64.5%), from Java (60.9), third grade (66.7%), living with parents (74.8%), and from the faculty of medicine (23.3%). More college students are not depressed (55.0%) or not stressed (57.4%) than those who are depressed or stressed. However, more college students experience anxiety than those who are not anxious, 60.1%. Based on the level, most college students experienced moderate depression (12.8%), very severe anxiety (20.9%), and severe stress (13.6%). This study concludes that most college students experience moderate depression, very severe anxiety, and severe stress. The success of online education depends on several factors, such as basic technical skills and the ability to access hardware and software, good self-motivation, and the availability of a conducive learning environment. This problem can have an impact on the mental health of college students. TINGKAT DEPRESI, KECEMASAN, DAN STRES PADA MAHASISWA DI INDONESIA SELAMA MASA PANDEMI COVID-19Pandemi COVID-19 menyebabkan peralihan metode pembelajaran menjadi daring. Terdapat manfaat dan kendala pada pembelajaran daring. Kendala yang dirasakan mahasiswa dapat berdampak pada kesehatan mental. Data kesehatan mental mahasiswa di Indonesia selama pandemik masih terbatas. Penelitian ini bertujuan menggambarkan depresi, kecemasan, dan stres pada mahasiswa di Indonesia selama masa pandemi COVID-19. Metode penelitian adalah deskriptif yang dilakukan pada mahasiswa di Indonesia pada Juli hingga Agustus 2021. Pengambilan sampel dengan cara sampling sukarela dengan jumlah responden 258 orang. Instrumen penelitian berupa kuesioner karakteristik dan depression, anxiety, stress scale (DASS) 42 dalam bentuk Google Form. Analisis data menggunakan Microsoft Excel. Hasil penelitian karakteristik responden yang terbanyak, yaitu usia pada rentang 20–24 tahun (85,3%), perempuan (64,5%), berasal dari Pulau Jawa (60,9), tingkat tiga (66,7%), tinggal bersama orangtua (74,8%), dan dari fakultas kedokteran (23,3%). Lebih banyak mahasiswa yang tidak depresi (55,0%) atau tidak stres (57,4%) daripada yang depresi atau stres. Namun, lebih banyak mahasiswa yang mengalami kecemasan daripada yang tidak cemas, yaitu 60,1%. Berdasar atas tingkatannya, mahasiswa paling banyak mengalami depresi sedang (12,8%), kecemasan sangat berat (20,9%), dan stres berat (13,6%). Simpulan penelitian ini adalah sebagian besar mahasiswa mengalami depresi sedang, kecemasan sangat berat, dan stres berat. Keberhasilan pendidikan daring bergantung pada beberapa faktor seperti keterampilan teknis dasar dan kemampuan mengakses perangkat keras dan lunak, motivasi diri yang baik, serta ketersediaan lingkungan belajar yang kondusif. Terkendalanya hal ini dapat berdampak pada kesehatan mental mahasiswa.
      PubDate: Fri, 31 Dec 2021 00:00:00 +070
  • Antagonic Effect of Soursop Leaf Aqueous Extract and Doxorubicin
           Combination in MCF7 and T47D Breast Cancer Cell

    • Authors: Miranti Kania Dewi; Siti Annisa Devi Trusda, Lelly Yuniarti
      Abstract: The success of breast cancer therapy is still not optimal and the side effects caused by breast cancer therapy. The use of standard drug combinations with herbs is often used as co-chemotherapy and is believed to increase the drug's effectiveness. However, research on the antagonistic effect of the drug combination is still minimal. This study examines the anticancer effect of soursop leaf aquoxes extract and the combined impact of doxorubicin on MCF7 and T47D breast cancer cells. This research is pure in vitro experimental study of MCF7 and T47D breast cancer culture cells at the Parasitology Laboratory of the Faculty of Medicine, Universitas Gadjah Mada in August 2018. Toxicity tests were carried out using the method of tetrazolium 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) to calculate cell viability. The IC50 value was obtained by analyzing probit regression calculation using SPSS software. The synergism of this compound with doxorubicin was determined based on the value of the Combination Index (CI) using a combination test with series 1/2 IC50, 3/8 IC50, 1/4 IC50, and 1/8 IC50 and the data was analyzed using Compusyn 1.0 software. In this study, the effect of soursop leaf preparations will be tested on T47D and MCF7 breast cancer cell cultures and assess the impacts of co-chemotherapy of soursop leaf aqueous extract with doxorubicin. This study showed that IC50 soursop leaf aqueous extract in T47D breast cancer culture was 84 μg/mL and in MCF7 166.5 μg/mL. In contrast, the combined test showed that soursop leaf aqueous extract was antagonistic with doxorubicin in both T47D and MCF7 cancer cell cultures. EFEK ANTAGONIS KOMBINASI EXTRAK AIR DAUN SIRSAK DAN DOKSORUBISIN PADA KULTUR SEL KANKER MCF7 AND T47DKeberhasilan terapi kanker payudara saat ini masih belum optimal dan terdapat efek samping yang ditimbulkan dari terapi kanker payudara tersebut. Penggunaan kombinasi obat standar dengan herbal sering digunakan sebagai ko-kemoterapi dan diyakini dapat meningkatkan efektivitas obat, tetapi penelitian mengenai efek antagonis kombinasi obat masih sangat terbatas. Penelitian ini mengkaji efek antikanker ekstrak air daun sirsak dan kombinasinya dengan doksorubisin pada sel kanker payudara MCF7 dan T47D. Penelitian ini merupakan eksperimental murni secara in vitro pada sel kanker payudara MCF7 dan T47D di Laboratorium Parasitologi Fakultas Kedokteran Universitas Gadjah Mada periode Agustus 2018. Uji toksisitas dilakukan menggunakan metode tetrazolium 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) untuk menghitung viabilitas sel. Nilai IC50 didapatkan melalui analisis menggunakan perhitungan regresi probit menggunakan perangkat lunak SPSS. Efek sinergis senyawa ini dengan doksorubisin ditentukan berdasar atas nilai Indeks Kombinasi (IK) menggunakan uji kombinasi dengan seri 1/2 IC50, 3/8 IC50, 1/4 IC50, dan 1/8 IC50 serta data dianalisis menggunakan perangkat lunak Compusyn 1.0. Efek sediaan daun sirsak pada penelitian ini akan diujikan terhadap kultur sel kanker payudara T47D dan MCF7 serta menilai efek ko-kemoterapi ekstrak air daun sirsak dengan doksorubisin. Hasil penelitian ini menunjukkan bahwa IC50 ekstrak air daun sirsak pada kultur sel kanker T47D adalah 84 μg/mL dan pada kultur sel kanker MCF7 166.5 μg/mL, sedangkan uji kombinasi memperlihatkan bahwa ekstrak air daun sirsak berefek antagonis dengan doksorubisin pada kultur sel kanker T47D dan MCF7.
      PubDate: Fri, 31 Dec 2021 00:00:00 +070
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