Authors:Irfan Irfan; Norma Tiku Kambuno, Irwan Budiana, Korri El Khobar Abstract: Hepatitis B virus (HBV) infection has remained a global health problem. Around 2 billion people worldwide are infected, and more than 257 million are categorized as chronic patients with a risk of developing progressive liver diseases, such as cirrhosis, liver failure, and hepatocellular carcinoma. In 2013, East Nusa Tenggara province had the most hepatitis B cases in Indonesia. Several factors cause a lack of information on HBV prevalence in the general population. First, they are inadequate disease surveillance systems with a high possibility of some acute and chronic infections being unreported. Second, geographical barriers to achieving suitable and sufficient data collection, considering the total population of 250 million people distributed in more than 17,000 islands. Third, the limited testing facilities for detecting chronic HBV resulted in many people being undiagnosed. This study was conducted to discover the prevalence of hepatitis B in healthy populations. It was a cross-sectional study with a random sampling method from April 2016 to March 2020 in Kupang city, East Nusa Tenggara. Subjects are prison inmates, pregnant women, primary school students, high school students, health workers, orphanage children, and families who live under the same roof with hepatitis B patients. We screened 11,152 subjects for HBsAg positivity using the ELISA and rapid detection tests. We found that 1,490 subjects (13.3%) were reactive to HBsAg. This HBsAg-positive prevalence stood far above the national rate of 7.1% in 2013, meaning that Kupang city is a region with high hepatitis B endemicity. Therefore, the local government should develop prevention strategies, diagnosis, post-infection management, and effective treatment, including mass vaccination programs for at-risk groups. PubDate: Sun, 01 Jan 2023 00:00:00 +080
Authors:Hari Soekersi; Ignatius Irawan Hidayat, Annisa Fitriani Zeindadinanda, Viola Stephanie Warokko Abstract: Cervical cancer is the second most common gynecologic malignancy in Asia and is the leading cause of death in women in developing countries. The cervical cancer stage will significantly affect the prognosis and management. Based on the International Federation of Gynecology and Obstetrics (FIGO) 2018 classification of cervical cancer, magnetic resonance imaging (MRI) has a crucial role in determining cervical cancer staging. This study aimed to evaluate the role of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) sequences in assessing cervical carcinoma, with the pathological diagnosis being taken as the standard for cervical cancer diagnosis. This study was conducted on seven patients diagnosed with cervical cancer from pathological examination in January 2020 to March 2021 in the Department of Radiology Dr. Hasan Sadikin General Hospital Bandung. We detect the presence of locoregional lesions and extensions of cervical carcinoma using MRI with T2WI and DWI sequences in patients who have previously been diagnosed histopathologically. This study involved seven cervical cancer patients. Pelvic MRI with T2WI and DWI sequences was performed. The imaging results in these patients show that one patient has stage IB1 cervical cancer, four patients have stage IIB, one patient has stage IIIA, and one has stage IIIC1 cervical cancer. This study concluded that T2WI and DWI sequences in MRI are essential and sufficient for diagnosing cervical cancer. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Ismawati Ismawati; Enikarmila Asni, Ilhami Romus, Mukhyarjon Mukhyarjon, Winarto Winarto, Muhammad Fadhillah Arif, M Derillovyandra Dwi Anugrah Abstract: Various studies have been carried out to obtain proper management for atherosclerosis. Proteasome, a subcellular enzyme complex, is a potential therapeutic target for atherosclerosis. However, the effect of proteasome inhibitors on atherosclerosis still needs to be explored. It was an experimental study with a post-test-only control group design conducted at the Faculty of Medicine, Universitas Riau in Juni–November 2021. This study aimed to analyze the effects of proteasome inhibitors on catalase expression and intima-media thickness (IMT) in the thoracic aorta of atherosclerotic rats. Fifteen male Wistar rats were randomly divided into three groups (five rats per group), namely rats given standard feed (control, group I), rats induced atherosclerosis (group II), and rats induced atherosclerosis and given proteasome inhibitor (group III). The proteasome inhibitor, bortezomib, 50 µg/kgBW/day was given intraperitoneally on days one and three. After 4 days, rats were terminated, and the thoracic aorta was taken for the IMT analysis and catalase expression assessment using immunohistochemistry. Catalase expression was carried out quantitatively using Adobe Photoshop software. Analysis of variance test was used to compare the expression of catalase and IMT. A p value<0.05 was considered statistically significant. The results showed a significant decrease in IMT in group III compared to group II and an increase in catalase expression in group III compared to group II but not statistically significant. This study concludes that administration of bortezomib 50 µg/kg in atherosclerotic rats could inhibit thickening tunica intima-media in the thoracic aorta, although not significantly increasing the catalase expression. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Ni Made Elva Mayasari; Kristinawati Kristinawati, Rara Krisdayanti, Lisa Permata Sari Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitations associated with an increase in chronic inflammatory responses to the airways and lungs. COPD patients are more likely to be hospitalized and die from cardiovascular disease. This study aims to determine the factors associated with the incidence of electrocardiogram (ECG) abnormalities in COPD patients. This is a cross-sectional study with an analytical observational design. From October 30 to December 5, 2019, data was collected on 42 COPD patients, inpatients, and outpatients at Muhammadiyah Palembang Hospital who met the inclusion and exclusion criteria. A questionnaire was used to collect data, and spirometry and an electrocardiogram test were used to measure pulmonary function and detect ECG abnormalities. Research variables included age, sex, smoking habits, severity, and duration of COPD. Data analysis using the chi-square test and followed by a logistic regression test found a significant relationship between very heavy-weight COPD and ≥5 years of suffering from COPD with the incidence of ECG abnormality (p value<0.05). The severity and the length of time of suffering from COPD are significantly related to the incidence of ECG abnormalities in outpatients and inpatients. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Ekawati Ekawati; Yuliani Setyaningsih, Ida Wahyuni Abstract: Smoked fish is an essential commodity in Central Java. Smoked fish workers must always ensure the availability of smoked fish products for the community. To work continuously, workers need to maintain their safety and health. Workers are constantly exposed to potential hazards from their work. This study aimed to describe the potential occupational hazards of smoked fish workers and identify efforts to control these hazards. This descriptive research involved smoked fish workers cleaning, cutting, washing, and smoking fish in Demak city, Central Java. The job safety analysis (JSA) method was used to describe potential hazards in every work process. The results showed that the potential risks found in the working process of smoking fish were a wet and humid work environment, sharp work equipment, non-ergonomic work postures, and a hot work climate. It can be concluded that workers are exposed to various hazards in their work and work environment. Therefore, it is necessary to increase occupational safety and health (OSH) awareness and working environment conditions in the smoked fish industry so that workers will always be safe and healthy at work. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Windi Nurdiawan; Setyorini Irianti, Dyah Ayu Puspita, Alfonsus Zeus, Billy Nusa Anggara, Vebri Anita Sinaga, Wulan Ardhana Iswari, Will Hans, Eduward Yacub Prasangka, Fadhilah Zulfa Abstract: Fetal growth restriction is a prevalent pregnancy issue linked to numerous unfavorable postnatal outcomes. Suboptimal uterine-placental perfusion and inadequate fetal feeding are the vital pathophysiologic causes. Midwives play a crucial role in informing pregnant women about vitamin D inadequacy. This paper aims to determine the difference between midwives' prior and post-webinar knowledge levels. It was a cross-sectional study of individuals who participated in a webinar on November 21, 2021. Subjects were selected using a total population sampling approach from all midwives who participated in the webinar and completed pre-and post-tests. The difference between knowledge levels was evaluated using the difference between the pre-test and post-test scores in the general category. There was an increase in the number of participants who successfully answered the five-question component, a decrease in the number of participants who correctly answered the two-question section, and no change in the number of subjects who correctly answered question number one. The average score on the post-test was higher (67.28) than the pre-test (63.10), while the median score was the same at both time points. After attending a webinar, there was an increase in the proportion of subjects with a high level of knowledge (11.4% to 24%) and a drop in the proportion of subjects with a poor level of knowledge (32.3% to 27.1%). In conclusion, there was an improvement in the knowledge level of midwives before and after the webinar participation. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Meta Maulida Damayanti; Raden Anita Indriyanti, Yuktiana Kharisma, Yuke Andriane, Uci Ari Lantika, Ratna Damailia, Meike Rachmawati Abstract: The main aim of the registered purple sweet potato (Ipomoea batatas) is to provide minimize the adverse chemical drugs, in addition to its anti-inflammatory, antioxidant, and antimicrobial effects. Potentially adverse effects may be observed in laboratory animals in particular, the extent to which this administration can cause toxicity. This study aimed to examine the histopathology of nephrotoxicity associated with administered water extracts of purple sweet potato in mice with stratified doses. The study was conducted at the Biomedical Laboratory, Faculty of Medicine, Universitas Islam Bandung on September 2019. Female mice (Mus musculus) strain Swiss Webster, aged between 6–8 weeks weighing 25 to 30 g, were obtained from Biopharma Laboratory, Bandung. The animal was acclimatized for seven days before being administered water extract purple sweet potato: eleven mice, one control group, and ten treatment groups underwent toxicity doses of purple sweet potato water extract administration. Purple sweet potato variant of Ayamurasaki prepared in various oral doses. The results show in the control group there were no histopathological changes, but in the group administered water extract purple sweet potato from the first phase seems in a mild grade of macrophage accumulation, mild vacuolization of tubular epithelial cells, mild vascular dilatation, and mild hydrophilic degeneration. In the second phase, macrophage accumulation was visible in moderate grades. The LD50 of purple sweet potato extract is greater than 5,000 mg/kgBW. The findings of this study indicate that registration of purple sweet potato extract in confirmatory doses is safe to administer and did not exhibit any mortality. The toxicity test of purple sweet potato water extracts in the kidney exhibits minimal chemical effects. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Salsabila Salsabila; Ernawaty Ernawaty Abstract: Telemedicine is the impact of industrial revolution 4.0, which urges the development of health system technology to increase access to health services. This condition is contrary to the use of society, where consumers decide to stop using telemedicine services after several benefits. So this study aims to identify the effect of psychosocial factors on consumer decisions in utilizing telemedicine services—analytical observational research with a cross-sectional design. The population of this study was consumers aged 17–39 years who needed access to health services. Data collection was done by distributing online questionnaires that have been tested for validity and reliability. One hundred ninety-eight respondents' responses were obtained in January–May 2021 using descriptive analysis and statistical tests. Statistical research showed that consumer psychological factors, including motivation, psychology, and learning, influenced decisions to use telemedicine services (Sig<0.05). Meanwhile, the social factors of the reference group did not have a significant effect (Sig>0.05). High motivation, positive perception, learning, and family encouragement influence consumer decisions to use telemedicine services, whereas the reference group does not. This research can be used as a consideration for developers and decision-makers in promoting the use of telemedicine so that it continues to be used in the long term. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Yani Triyani; Julia Hartati, Budiman Budiman, Ida Parwati, Bachti Alisjahbana Abstract: The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor (MMR) gene, and the most virulent antigen (the mannose-capped lipoarabinomannan) cell wall of virulent strains of Mycobacterium tuberculosis trigger an innate and adaptive immune response. It also produces pro and anti-inflammatory cytokines, which play a role in the pathogenesis of tuberculosis (TB) infection. Therefore, MMR gene polymorphism is a risk factor and is associated with the prognosis for active pulmonary TB. This study aimed to determine the correlation between MMR gene polymorphism and active or latent pulmonary tuberculosis. In this phase, MMR gene polymorphism was analyzed using a case-control design consisting of 74 control group subjects (patients with latent TB) and 74 case groups (patients with active pulmonary TB). The subject’s MMR gene DNA sequencing examination. The study was conducted at the Teaching Hospital, Faculty of Medicine, Universitas Padjadjaran Bandung, from February 2014 to January 2015. The statistical analysis used chi-square and odds ratio. The study’s result has shown the MMR gene polymorphism factor that correlated to the incidence of active pulmonary TB was T1212C (OR=0.253; 95% CI=0.111−0.575; p=0.001). There was an MMR gene in one SNP in the control group (C1323T) only and five single nucleotide polymorphisms (SNPs) in both groups (C1303T, C1221, T1212C, G1186A, and G1195A). Therefore, it can be concluded that MMR gene polymorphism on the T1212C site correlated with the incidence of active pulmonary tuberculosis and was protective. PubDate: Sat, 31 Dec 2022 00:00:00 +080
Authors:Nurin Fauziyah; Ratna Feti Wulandari, Luluk Susiloningtyas Abstract: Body weight or anthropometric measure is the most important and most frequently used measure to see the development of infants. Stimulating the growth in infants aged 4 to 6 months can be done in two ways: massage the baby's body and continue by bathing or swimming. This study aimed to analyze the effect of massage and bathing or swimming on an infant's weight gain in Kinara Mom and Baby Spa, Kerkep village, Gurah district, Kediri regency. The research design is quasi-experimental, with one group pre-test-post-test design approach, carried out in August–October 2021. The sample was babies aged 4–6 months using purposive sampling with a sample size of 20 babies—independent variables were baby massage and bathing or swimming on infants, and the dependent variable was weight gain. The instrument used is a weight-monitoring sheet. Data were analyzed using pairs sample t-test analysis. The results showed that all 20 babies experienced weight gain. The conclusion is that massage and bathing or swimming affect weight gain in infants aged 4–6 months. PubDate: Fri, 30 Dec 2022 00:00:00 +080
Authors:Noer Endah Pracoyo; Made Ayu Lely Suratri, Felly Philipus Senewe, Vivi Setiawaty Abstract: Hepatitis B (HBV) is still a major health problem worldwide, as evidenced by the large number of people infected with hepatitis. There are around two billion people infected with HBV, and an estimated 350 million are in chronic conditions. Hepatitis B is a ninth-order disease that causes death in mothers and their babies. The HBV infection in pregnant women is critical because of vertical or perinatal transmission. This study's purpose was to analyze data of the HBsAg and anti-HBs rertile age women, pregnant women, and postpartum mothers from National Basic Health Research Data 2007. The method is a retrospective study using secondary data from the Basic Health Research in 2007. The number of samples in the form of data on respondents of fertile age women are women aged 15 to 49 years. Data screened and matched with that examined pregnancy/have had a postpartum examination/never checked neonates/had examined their toddlers. One thousand three hundred two (1,302) respondents were eligible to be sampled in this analysis. The variables analyzed were age and anti-HB titers in women of childbearing age 15 to 49 years who were not protected against hepatitis B, as much as 74.65% of the total 1,302 people. Three hundred thirty (330) respondents had anti-HBs titers. This study concludes respondents who are not married age 15–20 years showed relationship with negative anti-Hbs antibodies. PubDate: Wed, 28 Dec 2022 01:03:44 +080
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