Authors:Fathima Fabina, Syam Prasad PS, Fathima Hanan, Fathima PM, Dr.Ibrahim Afsal Abstract: The investigation focused on optimizing a gastric floating drug delivery system (GFDDS) for Ibuprofen tablets. It employed polymers like HPMC K4M and Carbopol 940 to improve Ibuprofen's bioavailability and therapeutic effectiveness. GFDDS, with lower bulk density than gastric fluids, remains buoyant in the stomach, extending gastric residence time. Compatibility assessments, via DSC analysis, indicated harmony between the polymers used, with no observed interaction between the polymer and the drug. The study aimed to formulate and characterize sustained-release floating tablets of Ibuprofen, utilizing HPMCK4M and Carbopol 940 as the selected polymers. Through this method, researchers sought to enhance drug delivery, ensuring sustained release and prolonged residence in the stomach for improved therapeutic outcomes. The incorporation of these polymers in the formulation aimed to address challenges associated with conventional drug delivery systems, potentially offering a more effective means of administering Ibuprofen. This investigation underscores the importance of tailored drug delivery systems in optimizing drug performance and enhancing patient outcomes, particularly in cases where sustained release and prolonged gastric residence are advantageous. PubDate: 2024-02-17 Issue No:Vol. 10, No. 3 (2024)
Authors:Darshan S. Bava, Vivek L. Ahire, Prashant B. Mahale, Komal M. Mahajan Abstract: India possesses a diverse range of medicinal herbs due to its unique environmental conditions and varied seasons, which provide an ideal environment for the growth of numerous plant species. One such plant is the tridax procumbens, an annual herb that spreads widely and is native to India. Belonging to the Asteraceae family, it is known as "Ghamra" among the local population and referred to as "coat buttons" in English. Additionally, some Ayurvedic practitioners recognize it by the name "Bhringraj". This herb is commonly found in wastelands and along roadsides. It is extensively utilized in ethnomedicine for the treatment of diverse ailments. The use of plant-derived substances and herbal medicines has garnered significant interest due to their versatile applications. Medicinal plants serve as a valuable source of bioactive compounds that are utilized in both traditional and modern medicine. Despite the availability of modern medicine, there has been a notable surge in the interest and utilization of herbal medicines in recent years. The aim of this study is to develop and evaluate formulations such as ointments, creams, and gels using Tridax procumbens. Medicinal plants are truly nature's gift to humanity, offering an immense potential for the treatment of various diseases. Exploring alternative natural microbial agents, such as plant extracts, is crucial in combating the rise of multidrug-resistant strains. PubDate: 2024-02-12 Issue No:Vol. 10, No. 3 (2024)
Authors:Sachin R.Gosavi, Vaibhav G. Badgujar, Vaishnavi D. Patil, Vaibhavi D. Patil, Pramod D. More Abstract: The cultivated sunflower, scientifically known as Helianthus annuus annuus L. has a place to the class Helianthus, which has sixty-five species in add up to. This sunflower is local to America and is frequently developed within the Joined together States. As a member of the Asteraceae family, the cultivated sunflower exhibits a characteristic composite flower. The main objective of this study was to develop, formulate, and assess a moisturizing cream that utilizes sunflower as its primary ingredient. It can be inferred that the hydrating cream contains sunflower wax, which harnesses its cosmetic benefits, owing to the presence of a specific proportion of stearic acid and sunflower wax as emulsifiers. The sunflower holds significant importance due to its nutritional and medicinal value. Its significant affect on wellbeing has driven to its acknowledgment as a useful nourishment or nutraceutical, in spite of the fact that its full potential is however to be completely realized. Sunflower is copious in fundamental minerals, phytochemicals, and vitamins, counting dietary fiber, manganese, tocopherols, phytosterols, triterpene glycosides, α-tocopherol, glutathione reductase, flavonoids, phenolic acids, carotenoids, peptides, chlorogenic corrosive, caffeic corrosive, alkaloids, tannins, and saponins. found within the Joined together States. These compounds play a crucial role in the development of functional and nutraceutical products derived from sunflower. As mentioned earlier, sunflower seeds are particularly rich in vitamin E. Consuming just one-fourth of a cup can provide the body with 80% of the daily requirement of vitamin E. Due to its high antioxidant content, vitamin E helps prevent signs of aging and promotes healthy blood circulation, rejuvenating the skin and reducing the appearance of wrinkles. PubDate: 2024-02-12 Issue No:Vol. 10, No. 3 (2024)
Authors:Dr. Himanshu Solanki, Nimisha Vala, Shruti Adhikari, Neha Patil, Jaydatta Dhakane, Ajinkya Thakare Abstract: Rivaroxaban, a prominent direct oral anticoagulant (DOAC), has garnered attention for its pivotal role in preventing and treating thromboembolic diseases. Its introduction into clinical practice has marked a significant advancement in anticoagulant therapy. The mechanism of action of rivaroxaban involves selective inhibition of factor Xa, a crucial component in the coagulation cascade. This targeted approach distinguishes it from traditional anticoagulant and contributes to its efficacy. The significance of rivaroxaban lies in its short half-life, consistent bioavailability and rapid absorption, rivaroxaban is especially remarkable since they provide converting dosage on a daily basis. Analysing actual scenarios demonstrates rivaroxaban’s dependability and efficacy in contemporary therapeutic practice. This research explores its pharmacokinetics and pharmacodynamic properties make it even more useful and contribute to a more complex understanding of its role. A thorough examination of its pharmacological profile sheds lights on its reliability and efficacy in a range of medical contexts. Furthermore, an accurate understanding of rivaroxaban’s role in anticoagulant therapy can be acquired by looking through significant papers and patents. An in-depth analysis of rivaroxaban pharmacological profile illuminates its reliability and efficacy across various medical scenarios. The study considers the drugs role in anticoagulant therapy, shedding light in its application and benefits. By reviewing pertinent papers and patents, an accurate understanding of rivaroxaban position in the realm of anticoagulation therapy is attained, further emphasizing its clinical importance. In conclusion, this research provides a comprehensive insight into rivaroxaban pharmacokinetics and pharmacodynamics, establishing its role as a crucial agent in the management of thromboembolic diseases. PubDate: 2024-02-12 Issue No:Vol. 10, No. 3 (2024)
Authors:Archana S, Dr Ibrahim Afsal V .T, Fathima Musthafal, Fathima PM, Ayisha Shafrin, Syamprasad PS Abstract: Meloxicam, recognized as a preferential COX-2 inhibitor, has emerged as a promising chemopreventive agent for colorectal cancer. Leveraging its local and targeted action on the colon, Meloxicam proves to be a formidable component in the prevention of colorectal malignancies. This study aims to innovate by formulating and evaluating a targeted tablet delivery system for Meloxicam, emphasizing site-specific and instant drug release in the colon, thereby maximizing its therapeutic efficacy in the treatment of colorectal cancer. Acknowledging Meloxicam's challenges as an extremely poorly soluble acidic drug with pH-dependent solubility, the formulation incorporates buffering agents to ensure pH-independent drug release upon reaching the colon. In vitro evaluations of the coated tablets, containing 2% croscarmelose and 4% crospovidone as disintegrants, demonstrate immediate drug release within the colon. Notably, the tablet's drug content, standing at 96.9%, aligns with the standards outlined by the United States Pharmacopeia (USP). This substantiates the formulation's compliance with regulatory benchmarks, indicating its potential for clinical application. In conclusion, this study affirms the efficacy of the Meloxicam targeted tablet formulation, showcasing its potential as an advanced and targeted drug delivery system for the treatment of colorectal cancer. PubDate: 2024-01-16 Issue No:Vol. 10, No. 3 (2024)
Authors:Mekkanti Manasa Rekha Pages: 36 - 49 Abstract: Medication Reconciliation is defined as the process where the health care providers work with the patients to document communicate the comprehensive medication information by complete medication list and then reconciling it against what patient has been actually intended to take or taking in order to identify the drug related problems like drug interactions, medication errors and adverse drug reactions. Cancer patients are categorized as vulnerable population as they have many risk factors even cancer patients have been administered by various therapies like chemotherapy, biological agents, hormone therapy, supportive therapy that can leads to poly pharmacy by increasing the risk of drug related problems so it is required to impose the medication reconciliation practice strictly to ensure whether medications are optimized or not and to achieve desired therapeutic outcomes and in promotion of rational practice of drug usage .The present study involves in detail study of anti-cancer drug usage through critical case and prescription analysis to identify, analyze and report the drug related problems during the course of treatment.261 patients were enrolled in the study. A total of 17 Adverse drug reactions were screened during study period with causality and severity assessment, 22 prescriptions comprised of potential drug interactions with 79medication errors .The present study clearly states the Impact and outcomes of clinical pharmacist based medication reconciliation practice in promotion of rational drug usage and in minimization of drug related problems. PubDate: 2023-12-12 Issue No:Vol. 10, No. 3 (2023)
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