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EMERGENCY AND INTENSIVE CRITICAL CARE (121 journals)                     

Showing 1 - 124 of 124 Journals sorted alphabetically
AACN Advanced Critical Care     Full-text available via subscription   (Followers: 36)
Academic Emergency Medicine     Hybrid Journal   (Followers: 90)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acute and Critical Care     Open Access   (Followers: 9)
Acute Cardiac Care     Hybrid Journal   (Followers: 11)
Acute Medicine     Full-text available via subscription   (Followers: 8)
Advances in Emergency Medicine     Open Access   (Followers: 16)
Advances in Neonatal Care     Hybrid Journal   (Followers: 43)
African Journal of Anaesthesia and Intensive Care     Full-text available via subscription   (Followers: 7)
African Journal of Emergency Medicine     Open Access   (Followers: 7)
AINS - Anasthesiologie - Intensivmedizin - Notfallmedizin - Schmerztherapie     Hybrid Journal   (Followers: 5)
American Journal of Emergency Medicine     Hybrid Journal   (Followers: 54)
Annals of Emergency Medicine     Hybrid Journal   (Followers: 126)
Annals of Intensive Care     Open Access   (Followers: 37)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 15)
Archives of Academic Emergency Medicine     Open Access   (Followers: 6)
Archives of Trauma Research     Open Access   (Followers: 4)
ASAIO Journal     Hybrid Journal   (Followers: 2)
Australasian Journal of Paramedicine     Open Access   (Followers: 7)
Australian Critical Care     Full-text available via subscription   (Followers: 21)
Bangladesh Critical Care Journal     Open Access   (Followers: 1)
BMC Emergency Medicine     Open Access   (Followers: 25)
BMJ Quality & Safety     Hybrid Journal   (Followers: 65)
Burns Open     Open Access  
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal   (Followers: 2)
Case Reports in Acute Medicine     Open Access   (Followers: 3)
Case Reports in Critical Care     Open Access   (Followers: 13)
Case Reports in Emergency Medicine     Open Access   (Followers: 19)
Chronic Wound Care Management and Research     Open Access   (Followers: 7)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 32)
Clinical Intensive Care     Hybrid Journal   (Followers: 6)
Clinical Medicine Insights : Trauma and Intensive Medicine     Open Access   (Followers: 3)
Clinical Risk     Hybrid Journal   (Followers: 5)
Crisis: The Journal of Crisis Intervention and Suicide Prevention     Hybrid Journal   (Followers: 15)
Critical Care     Open Access   (Followers: 74)
Critical Care and Resuscitation     Full-text available via subscription   (Followers: 29)
Critical Care Clinics     Full-text available via subscription   (Followers: 34)
Critical Care Explorations     Open Access   (Followers: 3)
Critical Care Medicine     Hybrid Journal   (Followers: 279)
Critical Care Research and Practice     Open Access   (Followers: 13)
Current Emergency and Hospital Medicine Reports     Hybrid Journal   (Followers: 5)
Current Opinion in Critical Care     Hybrid Journal   (Followers: 73)
Disaster and Emergency Medicine Journal     Open Access   (Followers: 12)
Egyptian Journal of Critical Care Medicine     Open Access   (Followers: 2)
EMC - Urgenze     Full-text available via subscription  
Emergency Care Journal     Open Access   (Followers: 7)
Emergency Medicine (Medicina neotložnyh sostoânij)     Open Access  
Emergency Medicine Australasia     Hybrid Journal   (Followers: 17)
Emergency Medicine Clinics of North America     Full-text available via subscription   (Followers: 19)
Emergency Medicine International     Open Access   (Followers: 8)
Emergency Medicine Journal     Hybrid Journal   (Followers: 53)
Emergency Medicine News     Full-text available via subscription   (Followers: 7)
Emergency Nurse     Full-text available via subscription   (Followers: 17)
Enfermería Intensiva (English ed.)     Full-text available via subscription  
European Burn Journal     Open Access   (Followers: 10)
European Journal of Emergency Medicine     Hybrid Journal   (Followers: 23)
Frontiers in Emergency Medicine     Open Access   (Followers: 8)
Global Journal of Transfusion Medicine     Open Access   (Followers: 1)
Hong Kong Journal of Emergency Medicine     Full-text available via subscription   (Followers: 5)
Indian Journal of Burns     Open Access   (Followers: 2)
Injury     Hybrid Journal   (Followers: 20)
Intensive Care Medicine     Hybrid Journal   (Followers: 82)
Intensive Care Medicine Experimental     Open Access   (Followers: 2)
Intensivmedizin up2date     Hybrid Journal   (Followers: 4)
International Journal of Critical Illness and Injury Science     Open Access   (Followers: 1)
International Journal of Emergency Medicine     Open Access   (Followers: 9)
International Journal of Emergency Mental Health and Human Resilience     Open Access   (Followers: 2)
International Paramedic Practice     Full-text available via subscription   (Followers: 14)
Iranian Journal of Emergency Medicine     Open Access  
Irish Journal of Paramedicine     Open Access   (Followers: 2)
Journal Européen des Urgences et de Réanimation     Hybrid Journal   (Followers: 1)
Journal of Acute Care Physical Therapy     Hybrid Journal   (Followers: 3)
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)
Journal Of Cardiovascular Emergencies     Open Access  
Journal of Concussion     Open Access  
Journal of Critical Care     Hybrid Journal   (Followers: 48)
Journal of Critical Care Medicine     Open Access   (Followers: 18)
Journal of Education and Teaching in Emergency Medicine     Open Access   (Followers: 1)
Journal of Emergencies, Trauma and Shock     Open Access   (Followers: 13)
Journal of Emergency Medical Services     Full-text available via subscription   (Followers: 12)
Journal of Emergency Medicine     Hybrid Journal   (Followers: 53)
Journal of Emergency Medicine, Trauma and Acute Care     Open Access   (Followers: 25)
Journal of Emergency Practice and Trauma     Open Access   (Followers: 6)
Journal of Intensive Care     Open Access   (Followers: 9)
Journal of Intensive Care Medicine     Hybrid Journal   (Followers: 22)
Journal of Intensive Medicine     Open Access  
Journal of Neuroanaesthesiology and Critical Care     Open Access   (Followers: 3)
Journal of Stroke Medicine     Hybrid Journal  
Journal of the American College of Emergency Physicians Open     Open Access   (Followers: 1)
Journal of the Intensive Care Society     Hybrid Journal   (Followers: 4)
Journal of the Royal Army Medical Corps     Hybrid Journal   (Followers: 6)
Journal of Thrombosis and Haemostasis     Hybrid Journal   (Followers: 81)
Journal of Translational Critical Care Medicine     Open Access   (Followers: 5)
Journal of Trauma and Acute Care Surgery, The     Hybrid Journal   (Followers: 34)
La Presse Médicale Open     Open Access  
Médecine de Catastrophe - Urgences Collectives     Hybrid Journal  
Medicina Intensiva     Open Access   (Followers: 3)
Medicina Intensiva (English Edition)     Hybrid Journal   (Followers: 1)
Mediterranean Journal of Emergency Medicine & Acute Care : MedJEM     Open Access  
Notfall + Rettungsmedizin     Hybrid Journal   (Followers: 3)
OA Critical Care     Open Access   (Followers: 3)
OA Emergency Medicine     Open Access   (Followers: 2)
Open Access Emergency Medicine     Open Access   (Followers: 6)
Open Journal of Emergency Medicine     Open Access   (Followers: 2)
Palliative Care : Research and Treatment     Open Access   (Followers: 19)
Palliative Medicine     Hybrid Journal   (Followers: 54)
Prehospital Emergency Care     Hybrid Journal   (Followers: 19)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 41)
Research and Opinion in Anesthesia and Intensive Care     Open Access   (Followers: 3)
Resuscitation     Hybrid Journal   (Followers: 54)
Resuscitation Plus     Open Access   (Followers: 2)
Saudi Critical Care Journal     Open Access   (Followers: 2)
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine     Open Access   (Followers: 11)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 46)
Shock : Injury, Inflammation, and Sepsis : Laboratory and Clinical Approaches     Hybrid Journal   (Followers: 10)
Sklifosovsky Journal Emergency Medical Care     Open Access  
The Journal of Trauma Injury Infection and Critical Care     Full-text available via subscription   (Followers: 24)
Therapeutics and Clinical Risk Management     Open Access   (Followers: 2)
Transplant Research and Risk Management     Open Access  
Trauma Case Reports     Open Access   (Followers: 1)
Trauma Monthly     Open Access   (Followers: 3)
Visual Journal of Emergency Medicine     Full-text available via subscription   (Followers: 1)
Western Journal of Emergency Medicine     Open Access   (Followers: 11)
 AEM Education and Training : A Global Journal of Emergency Care     Open Access   (Followers: 1)

           

Similar Journals
Journal Cover
Critical Care Medicine
Journal Prestige (SJR): 3.116
Citation Impact (citeScore): 3
Number of Followers: 279  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0090-3493 - ISSN (Online) 1530-0293
Published by LWW Wolters Kluwer Homepage  [297 journals]
  • Probiotics in Critical Illness: A Systematic Review and Meta-Analysis of
           Randomized Controlled Trials

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      Authors: Sharif; Sameer; Greer, Alisha; Skorupski, Clarissa; Hao, Qiukui; Johnstone, Jennie; Dionne, Joanna C.; Lau, Vincent; Manzanares, William; Eltorki, Mohamed; Duan, Erick; Lauzier, Francois; Marshall, John C.; Heels-Ansdell, Diane; Thabane, Lehana; Cook, Deborah J.; Rochwerg, Bram
      Abstract: imageOBJECTIVES: To determine the safety and efficacy of probiotics or synbiotics on morbidity and mortality in critically ill adults and children.DATA SOURCES: We searched MEDLINE, EMBASE, CENTRAL, and unpublished sources from inception to May 4, 2021.STUDY SELECTION: We performed a systematic search for randomized controlled trials (RCTs) that compared enteral probiotics or synbiotics to placebo or no treatment in critically ill patients. We screened studies independently and in duplicate.DATA EXTRACTION: Independent reviewers extracted data in duplicate. A random-effects model was used to pool data. We assessed the overall certainty of evidence for each outcome using the Grading Recommendations Assessment, Development, and Evaluation approach.DATA SYNTHESIS: Sixty-five RCTs enrolled 8,483 patients. Probiotics may reduce ventilator-associated pneumonia (VAP) (relative risk [RR], 0.72; 95% CI, 0.59 to 0.89 and risk difference [RD], 6.9% reduction; 95% CI, 2.7–10.2% fewer; low certainty), healthcare-associated pneumonia (HAP) (RR, 0.70; 95% CI, 0.55–0.89; RD, 5.5% reduction; 95% CI, 8.2–2.0% fewer; low certainty), ICU length of stay (LOS) (mean difference [MD], 1.38 days fewer; 95% CI, 0.57–2.19 d fewer; low certainty), hospital LOS (MD, 2.21 d fewer; 95% CI, 1.18–3.24 d fewer; low certainty), and duration of invasive mechanical ventilation (MD, 2.53 d fewer; 95% CI, 1.31–3.74 d fewer; low certainty). Probiotics probably have no effect on mortality (RR, 0.95; 95% CI, 0.87–1.04 and RD, 1.1% reduction; 95% CI, 2.8% reduction to 0.8% increase; moderate certainty). Post hoc sensitivity analyses without high risk of bias studies negated the effect of probiotics on VAP, HAP, and hospital LOS.CONCLUSIONS: Low certainty RCT evidence suggests that probiotics or synbiotics during critical illness may reduce VAP, HAP, ICU and hospital LOS but probably have no effect on mortality.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Patient, Public, and Healthcare Professionals’ Sepsis Awareness,
           Knowledge, and Information Seeking Behaviors: A Scoping Review*

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      Authors: Fiest; Kirsten M.; Krewulak, Karla D.; Brundin-Mather, Rebecca; Leia, Madison P.; Fox-Robichaud, Alison; Lamontagne, François; Leigh, Jeanna Parsons; for Sepsis Canada
      Abstract: imageOBJECTIVES: Sepsis awareness and understanding are important aspects of prevention, recognition, and clinical management of sepsis. We conducted a scoping review to identify and map the literature related to sepsis awareness, general knowledge, and information-seeking behaviors with a goal to inform future sepsis research and knowledge translation campaigns.DESIGN: Scoping review.SETTING: Using Arksey and O’Malley’s methodological framework, we conducted a systematic search on May 3, 2021, across four databases (MEDLINE, EMBASE, CINAHL, and Education Research Complete). Title/abstract and full-text screening was done in duplicate. One researcher extracted the data for each included article, and a second researcher checked data accuracy. The protocol was registered on Open Science Framework (https://doi.org/10.17605/OSF.IO/YX7AU).SUBJECTS: Articles related to sepsis awareness, knowledge, and information seeking behaviors among patients, public, and healthcare professionals.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Of 5,927 unique studies, 80 reported on patient (n = 13/80;16.3%), public (n = 15/80;18.8%), or healthcare professional (nurses, physicians, emergency medical technicians) (n = 48/80; 60%) awareness and knowledge of sepsis. Healthcare professional awareness and knowledge of sepsis is high compared with patients/public. The proportion of patients/public who had heard of the term sepsis ranged from 2% (Japan) to 88.6% (Germany). The proportions of patients/public who correctly identified the definition of sepsis ranged from 4.2% (Singapore) to 92% (Sweden). The results from the included studies appear to suggest that patient/public awareness of sepsis gradually improved over time. We found that the definition of sepsis was inconsistent in the literature and that few studies reported on patient, public, or healthcare professional knowledge of sepsis risk factors. Most patient/public get their sepsis information from the internet, whereas healthcare professionals get it from their role in healthcare through job training or educational training.CONCLUSIONS: Patient, public, and healthcare professional awareness and knowledge of sepsis vary globally. Future research may benefit from a consistent definition as well as country-specific data to support targeted public awareness campaigns.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • The Impact of Health Information Technology for Early Detection of Patient
           Deterioration on Mortality and Length of Stay in the Hospital Acute Care
           Setting: Systematic Review and Meta-Analysis*

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      Authors: Herasevich; Svetlana; Lipatov, Kirill; Pinevich, Yuliya; Lindroth, Heidi; Tekin, Aysun; Herasevich, Vitaly; Pickering, Brian W.; Barwise, Amelia K.
      Abstract: imageOBJECTIVE: To evaluate the impact of health information technology (HIT) for early detection of patient deterioration on patient mortality and length of stay (LOS) in acute care hospital settings.DATA SOURCES: We searched MEDLINE and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus from 1990 to January 19, 2021.STUDY SELECTION: We included studies that enrolled patients hospitalized on the floor, in the ICU, or admitted through the emergency department. Eligible studies compared HIT for early detection of patient deterioration with usual care and reported at least one end point of interest: hospital or ICU LOS or mortality at any time point.DATA EXTRACTION: Study data were abstracted by two independent reviewers using a standardized data extraction form.DATA SYNTHESIS: Random-effects meta-analysis was used to pool data. Among the 30 eligible studies, seven were randomized controlled trials (RCTs) and 23 were pre-post studies. Compared with usual care, HIT for early detection of patient deterioration was not associated with a reduction in hospital mortality or LOS in the meta-analyses of RCTs. In the meta-analyses of pre-post studies, HIT interventions demonstrated a significant association with improved hospital mortality for the entire study cohort (odds ratio, 0.78 [95% CI, 0.70–0.87]) and reduced hospital LOS overall.CONCLUSIONS: HIT for early detection of patient deterioration in acute care settings was not significantly associated with improved mortality or LOS in the meta-analyses of RCTs. In the meta-analyses of pre-post studies, HIT was associated with improved hospital mortality and LOS; however, these results should be interpreted with caution. The differences in patient outcomes between the findings of the RCTs and pre-post studies may be secondary to confounding caused by unmeasured improvements in practice and workflow over time.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Electrical Impedance Tomography in Acute Respiratory Distress Syndrome
           Management

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      Authors: Jimenez; Jose Victor; Weirauch, Andrew J.; Culter, Christopher A.; Choi, Philip J.; Hyzy, Robert C.
      Abstract: imageOBJECTIVE: To describe, through a narrative review, the physiologic principles underlying electrical impedance tomography, and its potential applications in managing acute respiratory distress syndrome (ARDS). To address the current evidence supporting its use in different clinical scenarios along the ARDS management continuum.DATA SOURCES: We performed an online search in Pubmed to review articles. We searched MEDLINE, Cochrane Central Register, and clinicaltrials.gov for controlled trials databases.STUDY SELECTION: Selected publications included case series, pilot-physiologic studies, observational cohorts, and randomized controlled trials. To describe the rationale underlying physiologic principles, we included experimental studies.DATA EXTRACTION: Data from relevant publications were reviewed, analyzed, and its content summarized.DATA SYNTHESIS: Electrical impedance tomography is an imaging technique that has aided in understanding the mechanisms underlying multiple interventions used in ARDS management. It has the potential to monitor and predict the response to prone positioning, aid in the dosage of flow rate in high-flow nasal cannula, and guide the titration of positive-end expiratory pressure during invasive mechanical ventilation. The latter has been demonstrated to improve physiologic and mechanical parameters correlating with lung recruitment. Similarly, its use in detecting pneumothorax and harmful patient-ventilator interactions such as pendelluft has been proven effective. Nonetheless, its impact on clinically meaningful outcomes remains to be determined.CONCLUSIONS: Electrical impedance tomography is a potential tool for the individualized management of ARDS throughout its different stages. Clinical trials should aim to determine whether a specific approach can improve clinical outcomes in ARDS management.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • The Feasibility of Implementing Targeted SEDation in Mechanically
           Ventilated Emergency Department Patients: The ED-SED Pilot Trial*

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      Authors: Fuller; Brian M.; Roberts, Brian W.; Mohr, Nicholas M.; Faine, Brett; Drewry, Anne M.; Wessman, Brian T.; Ablordeppey, Enyo; Pappal, Ryan D.; Stephens, Robert J.; Sewatsky, Thomas; Cho, Nicholas S.; Yan, Yan; Kollef, Marin H.; Carpenter, Christopher R.; Avidan, Michael S.
      Abstract: imageOBJECTIVES: Deep sedation in the emergency department (ED) is common, increases deep sedation in the ICU, and is negatively associated with outcome. Limiting ED deep sedation may, therefore, be a high-yield intervention to improve outcome. However, the feasibility of conducting an adequately powered ED-based clinical sedation trial is unknown. Our objectives were to assess trial feasibility in terms of: 1) recruitment, 2) protocol implementation and practice change, and 3) safety. Patient-centered clinical outcomes were assessed to better plan for a future large-scale clinical trial.DESIGN: Pragmatic, multicenter (n = 3), prospective before-after pilot and feasibility trial.SETTING: The ED and ICUs at three medical centers.PATIENTS: Consecutive, adult mechanically ventilation ED patients.INTERVENTIONS: An educational initiative aimed at reliable ED sedation depth documentation and reducing the proportion of deeply sedated patients (primary outcome).MEASUREMENTS AND MAIN RESULTS: Sedation-related data in the ED and the first 48 ICU hours were recorded. Deep sedation was defined as a Richmond Agitation-Sedation Scale of –3 to –5 or a Sedation-Agitation Scale of 1–3. One thousand three hundred fifty-six patients were screened; 415 comprised the final population. Lighter ED sedation was achieved in the intervention group, and the proportion of deeply sedated patients was reduced from 60.2% to 38.8% (p < 0.01). There were no concerning trends in adverse events (i.e., inadvertent extubation, device removal, and awareness with paralysis). Mortality was 10.0% in the intervention group and 20.4% in the preintervention group (p < 0.01). Compared with preintervention, the intervention group experienced more ventilator-free days [22.0 (9.0) vs 19.9 (10.6)] and ICU-free days [20.8 (8.7) vs 18.1 (10.4)], p < 0.05 for both.CONCLUSIONS: This pilot trial confirmed the feasibility of targeting the ED in order to improve sedation practices and reduce deep sedation. These findings justify an appropriately powered clinical trial regarding ED-based sedation to improve clinical outcomes.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Platelet Phenotype and Function Changes With Increasing Duration of
           Extracorporeal Membrane Oxygenation

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      Authors: Van Den Helm; Suelyn; Yaw, Hui Ping; Letunica, Natasha; Barton, Rebecca; Weaver, Asami; Newall, Fiona; Horton, Stephen B.; Chiletti, Roberto; Johansen, Amy; Best, Derek; McKittrick, Joanne; Butt, Warwick; d’Udekem, Yves; MacLaren, Graeme; Linden, Matthew D.; Ignjatovic, Vera; Monagle, Paul
      Abstract: imageOBJECTIVES: To investigate platelet pathophysiology associated with pediatric extracorporeal membrane oxygenation (ECMO).DESIGN: Prospective observational study of neonatal and pediatric ECMO patients from September 1, 2016, to December 31, 2019.SETTING: The PICU in a large tertiary referral pediatric ECMO center.PATIENTS: Eighty-seven neonates and children (< 18 yr) supported by ECMO.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Arterial blood samples were collected on days 1, 2, and 5 of ECMO and were analyzed by whole blood flow cytometry. Corresponding clinical data for each patient was also recorded. A total of 87 patients were recruited (median age, 65 d; interquartile range [IQR], 7 d to 4 yr). The median duration of ECMO was 5 days (IQR, 3–8 d) with a median length of stay in PICU and hospital of 18 days (IQR, 10–29 d) and 35 days (IQR, 19–75 d), respectively. Forty-two patients (48%) had at least one major bleed according to a priori determined definitions, and 12 patients (14%) had at least one thrombotic event during ECMO. Platelet fibrinogen receptor expression decreased (median fluorescence intensity [MFI], 29,256 vs 26,544; p = 0.0005), while von Willebrand Factor expression increased (MFI: 7,620 vs 8,829; p = 0.0459) from day 2 to day 5 of ECMO. Platelet response to agonist, Thrombin Receptor Activator Peptide 6, also decreased from day 2 to day 5 of ECMO, as measured by binding with anti-P-selectin, PAC-1 (binds activated GPIIb/IIIa), and anti-CD63 monoclonal antibodies (P-selectin area under the curve [AUC]: 63.46 vs 42.82, respectively, p = 0.0022; PAC-1 AUC: 93.75 vs 74.46, p = 0.0191; CD63 AUC: 55.69 vs 41.76, p = 0.0020).CONCLUSIONS: The loss of platelet response over time may contribute to bleeding during ECMO. These novel insights may be useful in understanding mechanisms of bleeding in pediatric ECMO and monitoring platelet markers clinically could allow for prediction or early detection of bleeding and thrombosis.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Acquired von Willebrand Syndrome and Desmopressin Resistance During
           Venovenous Extracorporeal Membrane Oxygenation in Patients With COVID-19:
           A Prospective Observational Study

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      Authors: Kalbhenn; Johannes; Glonnegger, Hannah; Büchsel, Martin; Priebe, Hans-Joachim; Zieger, Barbara
      Abstract: imageOBJECTIVES: Although COVID-19 is associated with high von Willebrand factor (vWF) parameters promoting thrombosis, venovenous extracorporeal membrane oxygenation (vvECMO) is associated with the development of acquired von Willebrand syndrome (AVWS) promoting bleeding. This study was designed to assess both the incidence and severity of AVWS in COVID-19 patients undergoing vvECMO, and the benefit of comprehensive vWF analyses.DESIGN: Prospective observational study.SETTING: ICU at a tertiary-care center.PATIENTS: Twenty-seven consecutive COVID-19 patients with acute respiratory distress syndrome (ARDS) requiring vvECMO.MEASUREMENTS AND MAIN RESULTS: Comprehensive vWF analyses (including sodium dodecyl-sulfate polyacrylamide gel electrophoresis) were performed before, during, and after vvECMO. In a subgroup of 12 patients with AVWS, effectiveness of treatment with desmopressin was assessed. The patients’ mean age was 53 years (range, 23–73), 70% were male, and all had various comorbidities. Following markedly elevated vwf antigen (vWF: Ag; mean, 546% (sd, 282]), vWF collagen binding capacity (mean, 469% [sd, 271]), vWF activity (vWF:A; mean, 383% [sd, 132]), and factor VIII activity (mean, 302% [sd, 106]), and only borderline decreases in high-molecular-weight (HMW) vWF multimers before vvECMO, all of these variables decreased and HMW vWF multimers became undetectable within hours following initiation of vvECMO. All variables fully recovered within 3–38 hours after discontinuation of vvECMO. During vvECMO, decreases in the vWF:A/vWF:Ag ratio correlated with absent HMW vWF multimers. Desmopressin did not affect vWF parameters.CONCLUSIONS: In patients with COVID-19-associated ARDS, AVWS developed soon after initiation of vvECMO. The vWF:A/vWF:Ag ratio was a suitable screening test for AVWS. As desmopressin was ineffective, bleeding during vvECMO-associated AVWS should preferably be treated with concentrates containing vWF.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Outcomes After Direct Discharge Home From Critical Care Units: A
           Population-Based Cohort Analysis*

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      Authors: Martin; Claudio M.; Lam, Melody; Le, Britney; Pinto, Ruxandra; Lau, Vincent; Ball, Ian M.; Wunsch, Hannah; Fowler, Robert A.; Scales, Damon C.
      Abstract: imageOBJECTIVES: To compare health service use and clinical outcomes for patients with and without direct discharge to home (DDH) from ICUs in Ontario.DESIGN: Population-based, observational, cohort study using propensity scoring to match patients who were DDH to those not DDH and a preference-based instrumental variable (IV) analysis using ICU-level DDH rate as the IV.SETTING: ICUs in Ontario.PATIENTS: Patients discharged home from a hospitalization either directly or within 48 hours of care in an ICU between April 1, 2015, and March 31, 2017.INTERVENTION: DDH from ICU.MEASUREMENTS AND MAIN RESULTS: Among 76,737 patients in our cohort, 46,859 (61%) were DDH from the ICU. In the propensity matched cohort, the odds for our primary outcome of hospital readmission or emergency department (ED) visit within 30 days were not significantly different for patients DDH (odds ratio [OR], 1.00; 95% CI, 0.96–1.04), and there was no difference in mortality at 90 days for patients DDH (OR, 1.08; 95% CI, 0.97–1.21). The effect on hospital readmission or ED visits was similar in the subgroup of patients discharged from level 2 (OR, 0.98; 95% CI, 0.92–1.04) and level 3 ICUs (OR, 1.02; 95% CI, 0.96–1.09) and in the subgroups with cardiac conditions (OR, 1.03; 95% CI, 0.96–1.12) and noncardiac conditions (OR, 0.98; 95% CI, 0.94–1.03). Similar results were obtained in the IV analysis (coefficient for hospital readmission or ED visit within 30 d = –0.03 ± 0.03 (se); p = 0.3).CONCLUSIONS: There was no difference in outcomes for patients DDH compared with ward transfer prior to discharge when two approaches were used to minimize confounding within a large health systemwide observational cohort. We did not evaluate how patients are selected for DDH. Our results suggest that with careful patient selection, this practice might be feasible for routine implementation to ensure efficient and safe use of limited healthcare resources.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Emergency Department ICUs Add Value

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      Authors: Wessman; Brian T.; Mohr, Nicholas M.
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Can We Always Trust the Wisdom of the Body'

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      Authors: Marini; John J.
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Does Interrupting Self-Induced Lung Injury and Respiratory Drive Expedite
           Early Spontaneous Breathing in the Setting of Early Severe Diffuse Acute
           Respiratory Distress Syndrome'

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      Authors: Petitjeans; Fabrice; Leroy, Sandrine; Pichot, Cyrille; Ghignone, Marco; Quintin, Luc; Constantin, Jean-Michel
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Sepsis Awareness Is Good, Please Do Not Let It Be Misunderstood*

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      Authors: Mendelsohn; Sondra A.; Dellinger, R. Phillip
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • A Call for a Consensus Approach to the Design, Implementation, and
           Evaluation of Early Warning Systems*

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      Authors: Bhavani; Sivasubramanium V.
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Is “Set It and Forget It” Bad Medicine for Sedation and Analgesia for
           Intubated Emergency Department Patients'*

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      Authors: Winkle; Julie; Sevransky, Jonathan
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Home-Ward Bound'*

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      Authors: Rampon; Garrett; Simpson, Steven Q.
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Relative Hypoglycemia and Lower Hemoglobin A1c-Adjusted Time in Band Are
           Strongly Associated With Increased Mortality in Critically Ill Patients

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      Authors: Krinsley; James S.; Rule, Peter R.; Roberts, Gregory W.; Brownlee, Michael; Preiser, Jean-Charles; Chaudry, Sherose; Dionne, Krista D.; Heluey, Camilla; Umpierrez, Guillermo E.; Hirsch, Irl B.
      Abstract: imageOBJECTIVES: To determine the associations of relative hypoglycemia and hemoglobin A1c-adjusted time in blood glucose (BG) band (HA-TIB) with mortality in critically ill patients.DESIGN: Retrospective cohort investigation.SETTING: University-affiliated adult medical-surgical ICU.PATIENTS: Three thousand six hundred fifty-five patients with at least four BG tests and hemoglobin A1c (HbA1c) level admitted between September 14, 2014, and November 30, 2019.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Patients were stratified for HbA1c bands of
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Neurologic Outcomes of Survivors of COVID-19–Associated Acute
           Respiratory Distress Syndrome Requiring Intubation

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      Authors: Jaquet; Pierre; Legouy, Camille; Le Fevre, Lucie; Grinea, Alexandra; Sinnah, Fabrice; Franchineau, Guillaume; Patrier, Juliette; Marzouk, Mehdi; Wicky, Paul-Henri; Alexis Geoffroy, Pierre; Arnoult, Florence; Vledouts, Serafima; de Montmollin, Etienne; Bouadma, Lila; Timsit, Jean-François; Sharshar, Tarek; Sonneville, Romain
      Abstract: imageOBJECTIVES: To describe 3–6-month neurologic outcomes of survivors of COVID-19–associated acute respiratory distress syndrome, invasively ventilated in the ICU.DESIGN: A bicentric prospective study during the two first waves of the pandemic (March to May and September to December, 2020).SETTING: Two academic hospital ICUs, Paris, France.PATIENTS: Adult COVID-19–associated acute respiratory distress syndrome survivors, invasively ventilated in the ICU, were eligible for a neurologic consultation between 3 and 6 months post ICU discharge.INTERVENTIONS: Follow-up by face-to-face neurologic consultation.MEASURES AND MAIN RESULTS: The primary endpoint was favorable functional outcome defined by a modified Rankin scale score less than 2, indicating survival with no significant disability. Secondary endpoints included mild cognitive impairment (Montreal Cognitive Assessment score < 26), ICU-acquired weakness (Medical Research Council score < 48), anxiety and depression (Hospital Anxiety and Depression score> 7), and posttraumatic stress disorder (posttraumatic stress disorder checklist for Diagnostic and Statistical Manual of Mental Disorders 5 score> 30). Of 54 eligible survivors, four non-French-speaking patients were excluded, eight patients were lost-to-follow-up, and one died during follow-up. Forty-one patients were included. Time between ICU discharge and neurologic consultation was 3.8 months (3.6–5.9 mo). A favorable functional outcome was observed in 16 patients (39%) and mild cognitive impairment in 17 of 33 patients tested (52%). ICU-acquired weakness, depression or anxiety, and posttraumatic stress disorder were reported in six of 37 cases (16%), eight of 31 cases (26%), and two of 27 cases (7%), respectively. Twenty-nine patients (74%) required rehabilitation (motor, cognitive, or psychologic). ICU and hospital lengths of stay, tracheostomy, and corticosteroids were negatively associated with favorable outcome. By contrast, use of alpha-2 agonists during ICU stay was associated with favorable outcome.CONCLUSIONS: COVID-19–associated acute respiratory distress syndrome requiring intubation led to slight-to-severe functional disability in about 60% of survivors 4 months after ICU discharge. Cognitive impairment, muscle weakness, and psychologic symptoms were frequent. A large multicenter study is warranted to allow identification of modifiable factors for improving long-term outcome.
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Factors Associated With Prolonged Mechanical Ventilation in Nontraumatic
           Subarachnoid Hemorrhage

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      Authors: Siddiqui; Suhail Sarwar; Muzaffar, Syed Nabeel; Saran, Sai; Gurjar, Mohan
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • The authors reply

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      Authors: Rass; Verena; Helbok, Raimund
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Hyperbaric Oxygenation Therapy Alone for Carbon Monoxide Poisoning: Time
           for Reinforcements'

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      Authors: Honore; Patrick M.; Djimafo, Pharan; Preseau, Thierry; Cismas, Bogdan Vasile; Kaefer, Keitiane; Barreto Gutierrez, Leonel; Anane, Sami; Gallerani, Andrea; Attou, Rachid
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • The authors reply

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      Authors: Lee; Yoonsuk; Cha, Yong Sung
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Cerebral Tissue Oxygenation Monitoring for Guiding RBC Transfusion in
           Neurocritical Patients

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      Authors: Leal-Noval; Santiago R.; Rincón-Ferrari, María D.
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • The authors reply

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      Authors: Gouvea Bogossian; Elisa; Taccone, Fabio Silvio
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Fragility Index and Trial Sequential Analysis for Randomized Controlled
           Studies Testing IV Vitamin C in Critically Ill Patients

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      Authors: Vargas; Maria R.; Servillo, Giuseppe; Vargas, Maria
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • The authors reply

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      Authors: Lee; Zheng-Yii; Chin Han Lew, Charles; Stoppe, Christian; Hill, Aileen; Ortiz-Reyes, Alfonso; Dhaliwal, Rupinder; Heyland, Daren K.; Patel, Jayshil J.
      Abstract: imageNo abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Therapeutic Hyperthermia Is Associated With Improved Survival in Afebrile
           Critically Ill Patients With Sepsis: A Pilot Randomized Trial

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      Authors: Kula; Roman
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
  • Stability of Spo2/Fio2 and Respiratory Rate-Oxygenation Indexes in
           Critical Respiratory Disorders

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      Authors: Shen; Yanfei; Zhu, Lihong; Yan, Jing
      Abstract: No abstract available
      PubDate: Mon, 01 Aug 2022 00:00:00 GMT-
       
 
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