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Showing 1 - 103 of 103 Journals sorted alphabetically
AACN Advanced Critical Care     Full-text available via subscription   (Followers: 38)
Academic Emergency Medicine     Hybrid Journal   (Followers: 102)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acute and Critical Care     Open Access   (Followers: 10)
Acute Cardiac Care     Hybrid Journal   (Followers: 13)
Acute Medicine     Full-text available via subscription   (Followers: 7)
Advances in Emergency Medicine     Open Access   (Followers: 22)
Advances in Neonatal Care     Hybrid Journal   (Followers: 46)
African Journal of Anaesthesia and Intensive Care     Full-text available via subscription   (Followers: 8)
African Journal of Emergency Medicine     Open Access   (Followers: 6)
American Journal of Emergency Medicine     Hybrid Journal   (Followers: 58)
Annals of Emergency Medicine     Hybrid Journal   (Followers: 179)
Annals of Intensive Care     Open Access   (Followers: 40)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 17)
Archives of Academic Emergency Medicine     Open Access   (Followers: 7)
ASAIO Journal     Hybrid Journal   (Followers: 3)
Australian Critical Care     Full-text available via subscription   (Followers: 21)
Bangladesh Critical Care Journal     Open Access   (Followers: 1)
BMC Emergency Medicine     Open Access   (Followers: 30)
BMJ Quality & Safety     Hybrid Journal   (Followers: 67)
Burns Open     Open Access   (Followers: 1)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal   (Followers: 3)
Case Reports in Critical Care     Open Access   (Followers: 14)
Case Reports in Emergency Medicine     Open Access   (Followers: 23)
Chronic Wound Care Management and Research     Open Access   (Followers: 8)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 28)
Clinical Medicine Insights : Trauma and Intensive Medicine     Open Access   (Followers: 3)
Clinical Risk     Hybrid Journal   (Followers: 6)
Crisis: The Journal of Crisis Intervention and Suicide Prevention     Hybrid Journal   (Followers: 17)
Critical Care     Open Access   (Followers: 80)
Critical Care and Resuscitation     Full-text available via subscription   (Followers: 30)
Critical Care Clinics     Full-text available via subscription   (Followers: 37)
Critical Care Explorations     Open Access   (Followers: 3)
Critical Care Medicine     Hybrid Journal   (Followers: 388)
Critical Care Research and Practice     Open Access   (Followers: 13)
Current Emergency and Hospital Medicine Reports     Hybrid Journal   (Followers: 6)
Current Opinion in Critical Care     Hybrid Journal   (Followers: 74)
Disaster and Emergency Medicine Journal     Open Access   (Followers: 13)
Egyptian Journal of Critical Care Medicine     Open Access   (Followers: 2)
EMC - Urgenze     Full-text available via subscription  
Emergency Care Journal     Open Access   (Followers: 8)
Emergency Medicine (Medicina neotložnyh sostoânij)     Open Access  
Emergency Medicine Australasia     Hybrid Journal   (Followers: 19)
Emergency Medicine Clinics of North America     Full-text available via subscription   (Followers: 19)
Emergency Medicine Journal     Hybrid Journal   (Followers: 56)
Emergency Medicine News     Full-text available via subscription   (Followers: 7)
Emergency Nurse     Full-text available via subscription   (Followers: 17)
Enfermería Intensiva (English ed.)     Full-text available via subscription   (Followers: 2)
European Burn Journal     Open Access   (Followers: 7)
European Journal of Emergency Medicine     Hybrid Journal   (Followers: 25)
Hong Kong Journal of Emergency Medicine     Full-text available via subscription   (Followers: 5)
Injury     Hybrid Journal   (Followers: 23)
Intensive Care Medicine     Hybrid Journal   (Followers: 91)
Intensive Care Medicine Experimental     Open Access   (Followers: 2)
Intensivmedizin up2date     Hybrid Journal   (Followers: 4)
International Journal of Emergency Medicine     Open Access   (Followers: 10)
International Paramedic Practice     Full-text available via subscription   (Followers: 17)
Iranian Journal of Emergency Medicine     Open Access  
Irish Journal of Paramedicine     Open Access   (Followers: 3)
Journal of Acute Care Physical Therapy     Hybrid Journal   (Followers: 4)
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)
Journal Of Cardiovascular Emergencies     Open Access  
Journal of Concussion     Open Access  
Journal of Critical Care     Hybrid Journal   (Followers: 51)
Journal of Education and Teaching in Emergency Medicine     Open Access   (Followers: 1)
Journal of Emergency Medical Services     Full-text available via subscription   (Followers: 12)
Journal of Emergency Medicine     Hybrid Journal   (Followers: 53)
Journal of Emergency Medicine, Trauma and Acute Care     Open Access   (Followers: 28)
Journal of Emergency Practice and Trauma     Open Access   (Followers: 6)
Journal of Intensive Care     Open Access   (Followers: 9)
Journal of Intensive Care Medicine     Hybrid Journal   (Followers: 24)
Journal of Intensive Medicine     Open Access   (Followers: 1)
Journal of Neuroanaesthesiology and Critical Care     Open Access   (Followers: 4)
Journal of Stroke Medicine     Hybrid Journal   (Followers: 3)
Journal of the American College of Emergency Physicians Open     Open Access   (Followers: 2)
Journal of the Intensive Care Society     Hybrid Journal   (Followers: 5)
Journal of the Royal Army Medical Corps     Hybrid Journal   (Followers: 9)
Journal of Thrombosis and Haemostasis     Hybrid Journal   (Followers: 52)
Journal of Trauma and Acute Care Surgery, The     Hybrid Journal   (Followers: 39)
La Presse Médicale Open     Open Access  
Médecine de Catastrophe - Urgences Collectives     Hybrid Journal  
Medicina Intensiva     Open Access   (Followers: 3)
Medicina Intensiva (English Edition)     Hybrid Journal   (Followers: 1)
Mediterranean Journal of Emergency Medicine & Acute Care : MedJEM     Open Access  
Notfall + Rettungsmedizin     Hybrid Journal   (Followers: 4)
Open Access Emergency Medicine     Open Access   (Followers: 6)
Open Journal of Emergency Medicine     Open Access   (Followers: 2)
Palliative Care : Research and Treatment     Open Access   (Followers: 25)
Palliative Medicine     Hybrid Journal   (Followers: 59)
Prehospital Emergency Care     Hybrid Journal   (Followers: 20)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 26)
Resuscitation     Hybrid Journal   (Followers: 60)
Resuscitation Plus     Open Access   (Followers: 2)
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine     Open Access   (Followers: 14)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 28)
Shock : Injury, Inflammation, and Sepsis : Laboratory and Clinical Approaches     Hybrid Journal   (Followers: 12)
The Journal of Trauma Injury Infection and Critical Care     Full-text available via subscription   (Followers: 24)
Therapeutics and Clinical Risk Management     Open Access   (Followers: 1)
Transplant Research and Risk Management     Open Access   (Followers: 1)
Trauma Case Reports     Open Access   (Followers: 3)
Visual Journal of Emergency Medicine     Full-text available via subscription   (Followers: 1)
Western Journal of Emergency Medicine     Open Access   (Followers: 11)
 AEM Education and Training : A Global Journal of Emergency Care     Open Access   (Followers: 1)

           

Similar Journals
Journal Cover
Shock : Injury, Inflammation, and Sepsis : Laboratory and Clinical Approaches
Journal Prestige (SJR): 1.331
Citation Impact (citeScore): 3
Number of Followers: 12  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1073-2322 - ISSN (Online) 1540-0514
Published by LWW Wolters Kluwer Homepage  [330 journals]
  • SHOCK SYNOPSIS AUGUST 2024

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      Abstract: No abstract available
      PubDate: Thu, 01 Aug 2024 00:00:00 GMT-
       
  • CORRECTION FOR INDUCIBLE NITRIC OXIDE SYNTHASE-DEFICIENT MICE EXHIBIT
           RESISTANCE TO THE ACUTE PANCREATITIS INDUCED BY CERULEIN

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      Abstract: No abstract available
      PubDate: Thu, 01 Aug 2024 00:00:00 GMT-
       
  • CORRECTION FOR: THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ LIGAND
           15-DEOXYΔ12,14 PROSTAGLANDIN J2 REDUCES THE ORGAN INJURY IN HEMORRHAGIC
           SHOCK

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      Authors: Thiemermann; Christoph
      Abstract: No abstract available
      PubDate: Thu, 01 Aug 2024 00:00:00 GMT-
       
  • GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR
           ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT
           FERROPTOSIS

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      Authors: Wu; Zhixiang; Xi, Qiong; Zhao, Qin; Zhu, Shan
      Abstract: imageSepsis is a lethal clinical syndrome, and acute lung injury (ALI) is the earliest and most serious complication. We aimed to explore the role of growth differentiation factor 11 (GDF11) in sepsis-induced dysfunction of lung microvascular endothelial barrier in vivo and in vitro to elucidate its potential mechanism related to sirtuin 1 (SIRT1)/NADPH oxidase 4 (NOX4) signaling. Cecal ligation and puncture (CLP)-induced sepsis mice and lipopolysaccharide (LPS)-induced pulmonary microvascular endothelial cells (PMECs) were used in this study. Histopathological changes in lung tissues were tested by hematoxylin-eosin staining. Lung wet-to-dry weight ratio and inflammatory factors contents in bronchoalveolar lavage fluid were assessed. Evens blue index, trans-epithelial electrical resistance, and expression of zona occludens 1 (ZO-1), occludin-1, and claudin-1 were used to evaluate alveolar barrier integrity. Reactive oxygen species, lipid peroxidation, and ferroptosis markers were analyzed. Iron deposition in the lung tissues was assessed using Prussian blue staining. Intracellular Fe2+ level was detected using FerroOrange staining. Additionally, expression of GDF11, SIRT1, and NOX4 was estimated with western blot. Then, EX527, a SIRT1 inhibitor, was employed to treat GDF11-overexpressed PMECs with LPS stimulation to clarify the regulatory mechanism. Results showed that GDF11 overexpression attenuated sepsis-induced pathological changes and inflammation and maintained alveolar barrier integrity. Moreover, GDF11 overexpression inhibited ferroptosis, upregulated SIRT1 expression and downregulated NOX4 expression. Additionally, EX527 treatment relieved the impacts of GDF11 overexpression on ferroptosis and destruction of integrity of human pulmonary microvascular endothelial cells exposed to LPS. Taken together, GDF11 overexpression could alleviate sepsis-induced lung microvascular endothelial barrier damage by activating SIRT1/NOX4 signaling to inhibit ferroptosis. Our findings potentially provide new molecular target for clinical therapy of ALI.
      PubDate: Wed, 26 Jun 2024 00:00:00 GMT-
       
  • ANGIOTENSIN II IN THE TREATMENT OF DISTRIBUTIVE SHOCK: A SYSTEMATIC-REVIEW
           AND META-ANALYSIS

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      Authors: Xourgia; Eleni; Exadaktylos, Aristomenis K.; Chalkias, Athanasios; Ziaka, Mairi
      Abstract: imageObjective: While nonnorepinephrine vasopressors are increasingly used as a rescue therapy in cases of norepinephrine-refractory shock, data on their efficacy are limited. This systematic review and meta-analysis aims to synthesize existing literature on the efficacy of angiotensin II (ATII) in distributive shock. Methods: We preregistered our meta-analysis with PROSPERO (CRD42023456136). We searched PubMed, Scopus, and gray literature for studies presenting outcomes on ATII use in distributive shock. The primary outcome of the meta-analysis was all-cause mortality. We used a random effects model to calculate pooled risk ratio (RR) and 95% confidence intervals (CIs). Results: By incorporating data from 1,555 patients included in 10 studies, we found that however, all-cause mortality was similar among patients receiving ATII and controls (RR = 1.02; 95% CI: 0.89 to 1.16, P = 0.81), the reduction in norepinephrine or norepinephrine-equivalent dose at 3 h after treatment initiation was greater among patients receiving ATII (MD = −0.06; 95% CI: −0.11 to −0.02, P = 0.008), while there were no higher rates of adverse events reported among ATII patients. Conclusions: While ATII did not reduce mortality among distributive shock patients, it allowed for significant adjunctive vasopressor reduction at 3 h without an increase in reported adverse events, deeming it a viable alternative for the increasingly adopted multimodal vasopressor for minimizing catecholamine exposure and its adverse events.
      PubDate: Wed, 12 Jun 2024 00:00:00 GMT-
       
  • IDENTIFICATION OF A NOVEL SEPSIS PROGNOSIS MODEL: BASED ON TRANSCRIPTOME
           AND PROTEOME ANALYSIS

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      Authors: Chen; Haoran; Xue, Haoyue; Tang, Xinyi; Wang, Chen; Li, Xiaomin; Xie, Yongpeng
      Abstract: imageSepsis is a highly prevalent and deadly disease. Currently, there is a lack of ideal biomarker prognostis models for sepsis. We attempt to construct a model capable of predicting the prognosis of sepsis patients by integrating transcriptomic and proteomic data. Through analysis of proteomic and transcriptomic data, we identified 25 differentially expressed genes (DEGs). Single-factor Cox-Lasso regression analysis identified 16 DEGs (overall survival-DEGs) associated with patient prognosis. Through multifactor Cox-Lasso regression analysis, a prognostic model based on these 16 genes was constructed. Kaplan-Meier survival analysis and receiver operating characteristic curve analysis were used to further validate the high stability and good predictive ability of this prognostic model with internal and external data. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of overall survival-DEGs and differentially expressed genes between high and low-risk groups based on the prognostic model revealed significant enrichment in immune-related pathways, particularly those associated with viral regulation.
      PubDate: Wed, 12 Jun 2024 00:00:00 GMT-
       
  • INVESTIGATING THE RELATIONSHIP BETWEEN BLEEDING, CLOTTING, AND
           COAGULOPATHY DURING AUTOMATED PARTIAL REBOA STRATEGIES IN A HIGHLY LETHAL
           PORCINE HEMORRHAGE MODEL

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      Authors: Renaldo; Antonio C.; Soudan, Hebah; Gomez, Micaela K.; Ganapathy, Aravindh S.; Cambronero, Gabriel E.; Patterson, James W. III; Lane, Magan R.; Sanin, Gloria D.; Patel, Nathan; Niebler, Jacob A. P.; Jordan, James E.; Williams, Timothy K.; Neff, Lucas P.; Rahbar, Elaheh
      Abstract: imageBackground: Death due to hemorrhagic shock, particularly, noncompressible truncal hemorrhage, remains one of the leading causes of potentially preventable deaths. Automated partial and intermittent resuscitative endovascular balloon occlusion of the aorta (i.e., pREBOA and iREBOA, respectively) are lifesaving endovascular strategies aimed to achieve quick hemostatic control while mitigating distal ischemia. In iREBOA, the balloon is titrated from full occlusion to no occlusion intermittently, whereas in pREBOA, a partial occlusion is maintained. Therefore, these two interventions impose different hemodynamic conditions, which may impact coagulation and the endothelial glycocalyx layer. In this study, we aimed to characterize the clotting kinetics and coagulopathy associated with iREBOA and pREBOA, using thromboelastography (TEG). We hypothesized that iREBOA would be associated with a more hypercoagulopathic response compared with pREBOA due to more oscillatory flow. Methods: Yorkshire swine (n = 8/group) were subjected to an uncontrolled hemorrhage by liver transection, followed by 90 min of automated pREBOA, iREBOA, or no balloon support (control). Hemodynamic parameters were continuously recorded, and blood samples were serially collected during the experiment (i.e., eight key time points: baseline (BL), T0, T10, T30, T60, T90, T120, T210 min). Citrated kaolin heparinase assays were run on a TEG 5000 (Haemonetics, Niles, IL). General linear mixed models were employed to compare differences in TEG parameters between groups and over time using STATA (v17; College Station, TX), while adjusting for sex and weight. Results: As expected, iREBOA was associated with more oscillations in proximal pressure (and greater magnitudes of peak pressure) because of the intermittent periods of full aortic occlusion and complete balloon deflation, compared to pREBOA. Despite these differences in acute hemodynamics, there were no significant differences in any of the TEG parameters between the iREBOA and pREBOA groups. However, animals in both groups experienced a significant reduction in clotting times (R time: P < 0.001; K time: P < 0.001) and clot strength (MA: P = 0.01; G: P = 0.02) over the duration of the experiment. Conclusions: Despite observing acute differences in peak proximal pressures between the iREBOA and pREBOA groups, we did not observe any significant differences in TEG parameters between iREBOA and pREBOA. The changes in TEG profiles were significant over time, indicating that a severe hemorrhage followed by both pREBOA and iREBOA can result in faster clotting reaction times (i.e., R times). Nevertheless, when considering the significant reduction in transfusion requirements and more stable hemodynamic response in the pREBOA group, there may be some evidence favoring pREBOA usage over iREBOA.
      PubDate: Tue, 11 Jun 2024 00:00:00 GMT-
       
  • INFLAMMATORY RESPONSES TO POLYMICROBIAL INTRA-ABDOMINAL SEPSIS ARE HIGHLY
           VARIABLE BUT STRONGLY CORRELATED TO ENTEROBACTERIACEAE OUTGROWTH

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      Authors: Bongers; Kale S.; Chanderraj, Rishi; Deng, Huiyin; Song, Yujing; Newstead, Michael W.; Metcalf, Joseph D.; Falkowski, Nicole R.; Puranik, Niyati; Kurabayashi, Katsuo; Dickson, Robert P.; Singer, Benjamin H.
      Abstract: imageSepsis is a common, heterogeneous, and frequently lethal condition of organ dysfunction and immune dysregulation due to infection. The causes of its heterogeneity, including the contribution of the pathogen, remain unknown. Using cecal slurry, a widely used murine model of intraperitoneal polymicrobial sepsis, as well as 16S ribosomal RNA sequencing and measurement of immune markers, we performed a series of translational analyses to determine whether microbial variation in cecal slurry composition (representing intra-abdominal pathogens) mediated variation in septic response. We found wide variation in cecal slurry community composition that changed markedly over the 24-h course of infection. This variation in cecal slurry bacteria led to large variation in physiologic and inflammatory responses. Severity of inflammatory response was positively correlated with intraperitoneal enrichment with Enterobacteriaceae. Likewise, in a human cohort of patients with intra-abdominal abscesses, Enterobacteriaceae was also associated with increased inflammatory markers. Taken together, these data demonstrate that intra-abdominal Enterobacteriaceae drives inflammation in sepsis both in animal models and human subjects. More broadly, our results demonstrate that pathogen identity is a major driver of the host response in polymicrobial sepsis and should not be overlooked as a major source of phenotypic heterogeneity.
      PubDate: Thu, 30 May 2024 00:00:00 GMT-
       
  • INHIBITION OF INTEGRIN VLA-3 AND TETRASPANIN CD151 PROTECTS AGAINST
           NEUTROPHIL-MEDIATED ENDOTHELIAL DAMAGE

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      Authors: Ciambella; Chelsey; Witt, Hadley; Dickinson, Catherine M.; Smith, Madison L.; Coburn, Nicholas; Messina, Nicholas; Heffernan, Daithi S.; Kim, Minsoo; Reichner, Jonathan S.
      Abstract: imageBackground: The recruitment of neutrophils to sites of localized injury or infection is initiated by changes on the surface of endothelial cells located in proximity to tissue damage. Inflammatory mediators, such as TNF-α, increase surface expression of adhesive ligands and receptors on the endothelial surface to which neutrophils tether and adhere. Neutrophils then transit through the activated endothelium to reach sites of tissue injury with little lasting vascular injury. However, in cases of sepsis, the interaction of endothelial cells with highly activated neutrophils can cause damage vascular damage. The identification of molecules that are essential for neutrophil diapedesis may reveal targets of therapeutic opportunity for preservation of endothelial function in the presence of critical illness. We tested the hypothesis that inhibition of neutrophil β1 integrin very late antigen-3 (VLA-3; α3β1) and/or inhibition of the tetraspanin (TM4) family member CD151 would protect against neutrophil-mediated loss of endothelial function. Methods: Blood was obtained from septic patients or healthy donors. Neutrophils were purified, and aliquots were treated with/without proinflammatory molecules. Confluent human umbilical vascular endothelial cells were activated with TNF-α. Electric cell impedance sensing was used to determine monolayer resistance over time after the addition of neutrophils that were treated with blocking antibodies against VLA-3 and/or CD151 or isotype controls. Groups (depending on relevancy) were analyzed by Mann-Whitney U test, Wilcoxon test, or repeated-measures one-way ANOVA. Results: Neutrophils from septic patients and neutrophils activated ex vivo reduced endothelial monolayer resistance to a greater extent than neutrophils from healthy donors. Antibody blockade of VLA-3 and/or CD151 significantly reduced activation-associated endothelial damage. Similar findings were demonstrated on fibronectin, collagen I, collagen IV, and laminin, suggesting that neutrophil surface VLA-3 and CD151 are responsible for endothelial damage regardless of substrata and are likely to be operative in all bodily tissues. Conclusion: This report identifies VLA-3 and CD151 on the activated human neutrophil, which are responsible for damage to endothelial function. Targeting these molecules in vivo may demonstrate preservation of organ function during critical illness.
      PubDate: Thu, 23 May 2024 00:00:00 GMT-
       
  • PLASMA DYNAMICS OF NEUTROPHIL EXTRACELLULAR TRAPS AND CELL-FREE DNA IN
           SEPTIC AND NONSEPTIC VASOPLEGIC SHOCK: A PROSPECTIVE COMPARATIVE
           OBSERVATIONAL COHORT STUDY

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      Authors: Coupland; Lucy A.; Spiro, Calista; Quah, Benjamin J-C.; Orlov, Anna; Browne, Anna; O’Meara, Connor H.; Kang, Chang-Won; Frost, Steve; Schulz, Luis; Lombardo, Lien; Parish, Christopher R.; Aneman, Anders
      Abstract: imageBackground: The association between neutrophil extracellular traps (NETs) and the requirement for vasopressor and inotropic support in vasoplegic shock is unclear. This study aimed to investigate the dynamics of plasma levels of NETs and cell-free DNA (cfDNA) up to 48 h after the admission to the intensive care unit (ICU) for management of vasoplegic shock of infectious (SEPSIS) or noninfectious (following cardiac surgery, CARDIAC) origin. Methods: This is a prospective, observational study of NETs and cfDNA plasma levels at 0H (admission) and then at 12H, 24H, and 48H in SEPSIS and CARDIAC patients. The vasopressor inotropic score (VIS), the Sequential Organ Failure Assessment (SOFA) score, and time spent with invasive ventilation, in ICU and in hospital, were recorded. Associations between NETs/cfDNA and VIS and SOFA were analyzed by Spearman’s correlation (rho), and between NETs/cfDNA and ventilation/ICU/hospitalization times by generalized linear regression. Results: Both NETs and cfDNA remained elevated over 48 h in SEPSIS (n = 46) and CARDIAC (n = 30) patients, with time-weighted average concentrations greatest in SEPSIS (NETs median difference 0.06 [0.02–0.11], P = 0.005; cfDNA median difference 0.48 [0.20–1.02], P < 0.001). The VIS correlated to NETs (rho = 0.3–0.60 in SEPSIS, P < 0.01, rho = 0.36–0.57 in CARDIAC, P ≤ 0.01) and cfDNA (rho = 0.40–0.56 in SEPSIS, P < 0.01, rho = 0.38–0.47 in CARDIAC, P < 0.05). NETs correlated with SOFA. Neither NETs nor cfDNA were independently associated with ventilator/ICU/hospitalization times. Conclusion: Plasma levels of NETs and cfDNA correlated with the dose of vasopressors and inotropes administered over 48 h in patients with vasoplegic shock from sepsis or following cardiac surgery. NETs levels also correlated with organ dysfunction. These findings suggest that similar mechanisms involving release of NETs are involved in the pathophysiology of vasoplegic shock irrespective of an infectious or noninfectious etiology.
      PubDate: Thu, 23 May 2024 00:00:00 GMT-
       
  • A NOVEL CIRC_SUPT3/MIR-185-5P/G3BP2 CERNA NETWORK REGULATES HIGH
           GLUCOSE–INDUCED INJURY IN MOUSE PODOCYTE MPC5 CELLS

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      Authors: Li; Yuting; Wang, Wenyan; Liu, Na; Wang, Kexie; Ren, Fei
      Abstract: imageBackground: Diabetic nephropathy (DN) is a complication of diabetes that is the leading cause of death in diabetic patients. Circular RNA (circRNA) is a hot topic in the research of human diseases. However, the role of circ_Supt3 in DN remains unclear. Methods: High glucose (HG) treatment of mouse podocyte (MPC5) cells to mimic DN cell injury. Quantitative real-time polymerase chain reaction was performed to detect the expression of circ_Supt3, microRNA-185-5p (miR-185-5p), and GTPase-activating protein-binding protein 2 (G3bp2). 5-Ethynyl-2′-deoxyuridine (EdU) and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium Bromide (MTT) assays were used to examine cell proliferation, and flow cytometry was used to detect cell apoptosis. Western blot was used to assess the levels of relative proteins. Enzyme-linked immunosorbent assay detected the inflammation cytokines. Dual-luciferase reporter and RNA pull-down assays were used to confirm the interaction of miR-185-5p and circ_Supt3 or G3bp2. Results: Circ_Supt3 and G3bp2 were highly expressed and miR-185-5p expression was diminished in DN mice. HG treatment inhibited cell proliferation and accelerated cell apoptosis and inflammation response, and the knockdown of circ_Supt3 reversed these effects. Bioinformatics predicted that circ_Supt3 contained a binding site for miR-185-5p, and G3bp2 was a direct target of miR-185-5p. Circ_Supt3 regulated G3bp2 expression by miR-185-5p. Moreover, the circ_Supt3/miR-185-5p/G3bp2 axis regulated the cell behavior of HG-induced MPC5 cells. Conclusion: Our findings suggest that the knockdown of circ_Supt3 protects mouse MPC5 cells against HG-induced cell injury via the miR-185-5p/G3bp2 axis.
      PubDate: Thu, 23 May 2024 00:00:00 GMT-
       
  • INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELLS-DERIVED
           EXTRACELLULAR VESICLES ATTENUATE LPS-INDUCED LUNG INJURY AND ENDOTOXEMIA
           IN MICE

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      Authors: Meng; Qinghe; Winston, Tackla; Ma, Julia; Song, Yuanhui; Wang, Chunyan; Yang, Junhui; Ma, Zhen; Cooney, Robert N.
      Abstract: imageIntroduction: We hypothesized extracellular vesicles (EVs) from preconditioned human-induced pluripotent stem cell–derived mesenchymal stem cells (iMSCs) attenuate LPS-induced acute lung injury (ALI) and endotoxemia. Methods: iMSCs were incubated with cell stimulation cocktail (CSC) and EVs were isolated. iMSC-EVs were characterized by size and EV markers. Biodistribution of intratracheal (IT), intravenous, and intraperitoneal injection of iMSC-EVs in mice was examined using IVIS. Uptake of iMSC-EVs in lung tissue, alveolar macrophages, and RAW264.7 cells was also assessed. C57BL/6 mice were treated with IT/IP iMSC-EVs or vehicle ± IT/IP LPS to induce ALI/acute respiratory distress syndrome and endotoxemia. Lung tissues, plasma, and bronchoalveolar lavage fluid (BALF) were harvested at 24 h. Lung histology, BALF neutrophil/macrophage, cytokine levels, and total protein concentration were measured to assess ALI and inflammation. Survival studies were performed using IP LPS in mice for 3 days. Results: iMSC-EV route of administration resulted in differential tissue distribution. iMSC-EVs were taken up by alveolar macrophages in mouse lung and cultured RAW264.7 cells. IT LPS-treated mice demonstrated marked histologic ALI, increased BALF neutrophils/macrophages and protein, and increased BALF and plasma TNF-α/IL-6 levels. These parameters were attenuated by 2 h before or 2 h after treatment with IT iMSC-EVs in ALI mice. Interestingly, the IT LPS-induced increase in IL-10 was augmented by iMSC-EVs. Mice treated with IP LPS showed increases in TNF-α and IL-6 that were downregulated by iMSC-EVs and LPS-induced mortality was ameliorated by iMSC-EVs. Administration of IT iMSC-EVs 2 h after LPS downregulated the increase in proinflammatory cytokines (TNF-α/IL-6) by LPS and further increased IL-10 levels. Conclusions: iMSC-EVs attenuate the inflammatory effects of LPS on cytokine levels in ALI and IP LPS in mice. LPS-induced mortality was improved with administration of iMSC-EVs.
      PubDate: Thu, 23 May 2024 00:00:00 GMT-
       
  • SIRTUIN 5 ALLEVIATES EXCESSIVE MITOCHONDRIAL FISSION VIA DESUCCINYLATION
           OF ATPASE INHIBITORY FACTOR 1 IN SEPSIS-INDUCED ACUTE KIDNEY INJURY

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      Authors: Li; Jiaxin; Yao, Yi; Lei, Xiaobao; Bao, Jingna; An, Sheng; Hu, Hongbin; Sha, Tong; Huang, Qiaobing; Li, Tao; Zeng, Zhenhua; Wang, Xiang; Cai, Shumin
      Abstract: imageSepsis-induced acute kidney injury (SAKI) poses a significant clinical challenge with high morbidity and mortality. Excessive mitochondrial fission has been identified as the central pathogenesis of sepsis-associated organ damage, which is also implicated in the early stages of SAKI. Sirtuin 5 (SIRT5) has emerged as a central regulator of cellular mitochondrial function; however, its role in the regulation of sepsis-induced excessive mitochondrial fission in kidney and the underlying mechanism remains unclear. In this study, SAKI was modeled in mice through cecal ligation and puncture, and in human renal tubular epithelial (HK-2) cells stimulated with lipopolysaccharide (LPS), to mimic the cell SAKI model. Our findings revealed that septic mice with a SIRT5 knockout exhibited shortened survival times and elevated levels of renal injury compared to wild-type mice, suggesting the significant involvement of SIRT5 in SAKI pathophysiology. Additionally, we observed that SIRT5 depletion led to increased renal mitochondrial fission, while the use of a mitochondrial fission inhibitor (Mdivi-1) reversed the detrimental effects caused by SIRT5 depletion, emphasizing the pivotal role of SIRT5 in preventing excessive mitochondrial fission. In vitro experiments demonstrated that the overexpression of SIRT5 effectively mitigated the adverse effects of LPS on HK-2 cells viability and mitochondrial fission. Conversely, downregulation of SIRT5 decreased HK-2 cells viability and exacerbated LPS-induced mitochondrial fission. Mechanistically, the protective function of SIRT5 may be in part, ascribed to its desuccinylating action on ATPase inhibitory factor 1. In conclusion, this study provides novel insights into the underlying mechanisms of SAKI, suggesting the possibility of identifying future drug targets in terms of improved mitochondrial dynamics by SIRT5.
      PubDate: Wed, 15 May 2024 00:00:00 GMT-
       
  • TEMPORAL CHANGES IN INNATE AND ADAPTIVE IMMUNITY DURING SEPSIS AS
           DETERMINED BY ELISPOT

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      Authors: Unsinger; Jacqueline; Osborne, Dale; Walton, Andrew H.; Han, Ethan; Sheets, Lauren; Mazer, Monty B.; Remy, Kenneth E.; Griffith, Thomas S.; Rao, Mahil; Badovinac, Vladimir P.; Brakenridge, Scott C.; Turnbull, Isaiah; Efron, Philip A.; Moldawer, Lyle L.; Caldwell, Charles C.; Hotchkiss, Richard S.
      Abstract: imageBackground: The inability to evaluate host immunity in a rapid quantitative manner in patients with sepsis has severely hampered development of novel immune therapies. The enzyme-linked immunospot (ELISpot) assay is a functional bioassay that measures the number of cytokine-secreting cells and the relative amount of cytokine produced at the single-cell level. A key advantage of ELISpot is its excellent dynamic range enabling a more precise quantifiable assessment of host immunity. Herein, we tested the hypothesis that the ELISpot assay can detect dynamic changes in both innate and adaptive immunity as they often occur during sepsis. We also tested whether ELISpot could detect the effect of immune drug therapies to modulate innate and adaptive immunity. Methods: Mice were made septic using sublethal cecal ligation and puncture. Blood and spleens were harvested serially, and ex vivo interferon γ and TNF-α production were compared by ELISpot and enzyme-linked immunosorbent assay. The capability of ELISpot to detect changes in innate and adaptive immunity due to in vivo immune therapy with dexamethasone, IL-7, and arginine was also evaluated. Results: ELISpot confirmed a decreased innate and adaptive immunity responsiveness during sepsis progression. More importantly, ELISpot was also able to detect changes in adaptive and innate immunity in response to immune-modulatory reagents, for example, dexamethasone, arginine, and IL-7, in a readily quantifiable manner, as predicted by the reagents known mechanisms of action. ELISpot and enzyme-linked immunosorbent assay results tended to parallel one another although some differences were noted. Conclusion: ELISpot offers a unique capability to assess the functional status of both adaptive and innate immunity over time. The results presented herein demonstrate that ELISpot can also be used to detect and follow the in vivo effects of drugs to ameliorate sepsis-induced immune dysfunction. This capability would be a major advance in guiding new immune therapies in sepsis.
      PubDate: Fri, 03 May 2024 00:00:00 GMT-
       
  • TRANSCRIPTOMIC DIFFERENCES IN PERIPHERAL MONOCYTE POPULATIONS IN SEPTIC
           PATIENTS BASED ON OUTCOME

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      Authors: Barrios; Evan L.; Rincon, Jaimar C.; Willis, Micah; Polcz, Valerie E.; Leary, Jack R.; Darden, Dijoia B.; Balch, Jeremy A.; Larson, Shawn D.; Loftus, Tyler J.; Mohr, Alicia M.; Wallet, Shannon; Brusko, Maigan A.; Balzano-Nogueira, Leandro; Cai, Guoshuai; Sharma, Ashish; Upchurch, Gilbert R. Jr; Kladde, Michael P.; Mathews, Clayton E.; Maile, Robert; Moldawer, Lyle L.; Bacher, Rhonda; Efron, Philip A.
      Abstract: imagePostsepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness with suboptimal outcomes. The underlying immunological response that determines these clinical trajectories remains poorly defined at the transcriptomic level. As classical and nonclassical monocytes are key leukocytes in both the innate and adaptive immune systems, we sought to delineate the transcriptomic response of these cell types. Using single-cell RNA sequencing and pathway analyses, we identified gene expression patterns between these two groups that are consistent with differences in TNF-α production based on clinical outcome. This may provide therapeutic targets for those at risk for chronic critical illness in order to improve their phenotype/endotype, morbidity, and long-term mortality.
      PubDate: Thu, 02 May 2024 00:00:00 GMT-
       
  • TAG-FREE GLYCOSYLATED RHMFG-E8 AS A THERAPY FOR ACUTE KIDNEY INJURY

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      Authors: Zhang; Fangming; Ma, Gaifeng; Chaung, Wayne; Jacob, Asha; Brenner, Max; Wang, Ping
      Abstract: imageBackground: Acute kidney injury (AKI) can result from renal ischemia and reperfusion (I/R) and often occurs during surgical procedures in cardiac, liver, kidney transplantation, and trauma-hemorrhage. Milk fat globule epidermal growth factor-factor VIII (MFG-E8) functions as a bridging molecule to promote the removal of dying cells by professional phagocytes. Because MFG-E8 promotes clearance of apoptotic cells, we have explored its therapeutic potential in various organ injury conditions. To develop human MFG-E8 as a potential therapy, we have generated a human cell-expressed, and thus glycosylated, tag-free recombinant human (rh) MFG-E8 and tested its safety and biological activity in vitro. We hypothesize that the tag-free glycosylated rhMFG-E8 is protective in I/R-induced AKI and it can be developed as an effective therapy for AKI. Methods: To assess the pharmacokinetic properties of the tag-free rhMFG-E8, Sprague-Dawley rats were either untreated or treated with a bolus dose of the tag-free rhMFG-E8, blood collected at various time points and the recovery of human MFG-E8 in the blood were measured by ELISA. Adult male C57BL6 mice underwent bilateral renal ischemia for 30 min, and immediately upon reperfusion, mice were treated intraperitoneally with either normal saline (vehicle) or 20 μg/kg human cell expressed, glycosylated tag-free rhMFG-E8. At either 24 h or 48 h after I/R, blood and kidneys were harvested for further analysis. In separate cohorts of mice after I/R and treatment, mice were observed for 10 days, and survival recorded. Results: AKI rats treated with the tag-free rhMFG-E8 had similar half-life as those in the treated control rats. At 48 h after I/R-induced AKI, renal function markers, blood urea nitrogen, and creatinine were increased and treatment with the tag-free rhMFG-E8 significantly decreased these markers. At both 24 h and 48 h after AKI, inflammatory cytokines, TNF-α, IL-6, and IL-1β were increased and treatment decreased these levels. The kidney mRNA expressions of these cytokines were also increased at 24 h after AKI and treatment significantly decreased those mRNA expressions. Histologically, at 48 h after AKI, tubular damage, and the number of TUNEL staining cells were increased and treatment markedly decreased these measurements. Administration of tag-free rhMFG-E8 at the time of reperfusion improved survival in a 10-day survival study. Conclusion: Our new human cell-expressed tag-free rhMFG-E8 is protective in I/R-induced AKI and it may have the potential to be further developed as a safe and effective therapy for AKI.
      PubDate: Tue, 30 Apr 2024 00:00:00 GMT-
       
  • DEVELOPMENT AND VALIDATION OF A MODEL FOR PREDICTION OF SEPTIC SHOCK IN
           NEONATES WITH SEPSIS

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      Authors: Liu; Chunmei; Wang, Yanggan
      Abstract: imagePurpose: This study aimed to develop and validate a model for prediction of septic shock in neonates with sepsis. Materials and methods: This retrospective study included early-onset septic neonates in the Renmin Hospital of Wuhan University between January 2017 and June 2021. The neonates were divided into the training set and the validation set in a ratio of 7:3 and further categorized into septic shock group and none-shock group according to presence or absence of shock symptoms. Results: A total of 406 septic neonates were enrolled, including 217 in septic shock group. Sex (odds ratio [OR] = 0.092, 95% confidence interval [CI]: 0.012 to 0.683, P = 0.020), C-reactive protein at 6 h (OR = 8.475, 95% CI: 3.154 to 22.774, P < 0.001), serum amyloid A at 6 h (OR = 1.179, 95% CI: 1.094 to 1.269, P < 0.01), white blood cells at 6 h (OR = 0.173, 95% CI: 0.092 to 0.326, P < 0.001), platelets at 6 h (OR = 0.985, 95% CI: 0.975 to 0.995, P < 0.001), and Ca2+ at 6 h (OR = 1.44 × 1011, 95% CI: 2.70 × 106 to 7.70 × 1015, P < 0.001) were identified as independent risk factors for septic shock and were further included in the nomogram. The areas under the receiver operator characteristic curve were 0.873 and 0.920 in training and validation sets, respectively. Conclusions: A predictive model for early diagnosis of septic shock in neonates was developed and initially validated in this study, allowing for timely intervention.
      PubDate: Wed, 24 Apr 2024 00:00:00 GMT-
       
  • EFFECT OF PULMONARY ARTERY CATHETERIZATION IN PATIENTS WITH NONISCHEMIC
           CARDIOGENIC SHOCK: A NATIONWIDE ANALYSIS

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      Authors: Diaz-Arocutipa; Carlos; Moreno, Guillermo; Gil, David Galán; Nieto, Sara; Romo, Martín; Vicent, Lourdes
      Abstract: imageBackground: Pulmonary artery catheterization (PAC) has been widely used in critically ill patients, yielding mixed results. Prior studies on cardiogenic shock (CS) predominantly included patients with acute myocardial infarction. This study aims to examine the effect of PAC use in patients with nonischemic CS. Methods: This retrospective cohort study employed data from the National Inpatient Sample database, including weighted hospitalizations of adult patients with nonischemic CS during 2017 to 2019. In-hospital outcomes were compared between groups using inverse probability of treatment weighting. Results: A total of 303,970 patients with nonischemic CS were included, of whom 17.5% received a PAC during their hospitalization. The median age was 67 years (interquartile range: 57–77) and 61% were male. After inverse probability of treatment weighting, patients in the PAC group had significantly lower in-hospital mortality (24.8% vs. 35.3%, P < 0.001), renal replacement therapy (10.7% vs. 12.4%, P = 0.002), in-hospital cardiac arrest (7.1% vs. 9.6%, P < 0.001), and mechanical ventilation (44.6% vs. 50.4%, P < 0.001) compared to non-PAC group. In contrast, the PAC group had higher use of intra-aortic balloon pump (15.4% vs. 3.4%, P < 0.001), percutaneous ventricular assist devices (12.6% vs. 2.6%, P < 0.001), extracorporeal membrane oxygenation (3.9% vs. 2.5%, P < 0.001), and heart transplantation (2.1% vs. 0.4%, P < 0.001). Conclusion: In the real-world setting, invasive hemodynamic monitoring with PAC in patients with nonischemic CS is associated with survival benefits and a reduction in adverse events, including reduced need for renal replacement therapy, mechanical ventilation and risk of in-hospital cardiac arrest.
      PubDate: Tue, 09 Apr 2024 00:00:00 GMT-
       
  • WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES
           HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY

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      Authors: Fang; Mingcheng; Li, Ting; Wu, Zhiyong
      Abstract: imageBackground: Myocardial infarction (MI) is a severe condition that typically results from the ischemia and necrosis of heart muscle. Kruppel-like factor 6 (KLF6) can aggravate myocardial ischemia/reperfusion injury. This work aims to reveal its role and mechanism in hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury. Methods: Human cardiomyocyte (AC16) was exposed to hypoxic treatment to mimic MI-like cell injury. mRNA expression levels of KLF6 and WT1-associated protein (WTAP) were detected by quantitative real-time polymerase chain reaction. Protein expression was detected by western blotting assay. Cell viability was assessed by CCK-8 assay. Cell apoptosis and cell cycle were investigated by flow cytometry. Enzyme-linked immunosorbent assays were conducted to detect IL-1β, TNF-α and IL-6 levels. Fe2+ colorimetric assay kit was used to detect Fe2+ level. MDA Content Assay Kit was used to detect MDA level. Cellular ROS Assay kit was applied to assess ROS level. The association of KLF6 and WTAP was identified by RNA immunoprecipitation assay and dual-luciferase reporter assay. Results: KLF6 and WTAP expression at mRNA and protein levels were significantly upregulated in serum samples of MI patients and H/R-induced AC16 cells when compared with control groups. KLF6 silencing attenuated H/R-induced AC16 cell apoptosis, inflammatory response, oxidative stress, and ferroptosis. Additionally, WTAP stabilized KLF6 mRNA by regulating its m6A modification. Furthermore, WTAP knockdown rescued H/R-induced AC16 cell apoptosis, inflammatory response, oxidative stress, and ferroptosis by decreasing KLF6 expression. Conclusion: WTAP-mediated m6A modification of KLF6 aggravated hypoxia/reoxygenation-induced apoptosis, inflammatory response, oxidative stress, and ferroptosis of human cardiomyocytes, providing a therapeutic strategy for MI.
      PubDate: Tue, 09 Apr 2024 00:00:00 GMT-
       
  • UNVEILING THE CAUSAL ASSOCIATION BETWEEN NONINFECTIOUS RESPIRATORY
           DISORDERS AND SEPSIS THROUGH MENDELIAN RANDOMIZATION ANALYSIS

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      Authors: Liu; Cheng; He, Li; Zheng, Xiangde
      Abstract: imageBackground: The association between sepsis and noninfectious respiratory diseases is well-documented, yet the specific causal link between the two remains unclear. In order to explore this relationship further, we employed a Mendelian randomization (MR) analysis utilizing data from the UK Biobank and FinnGen Biobank. Methods: We analyzed the summary statistics of a genome-wide association study summary statistics for chronic obstructive pulmonary disease (COPD), asthma, pulmonary embolism (PE), idiopathic pulmonary fibrosis (IPF), obstructive sleep apnea (OSA), lung cancer, sepsis, and sepsis-related mortality. We employed the inverse-variance weighted (IVW) method and four additional MR methods. Heterogeneity and horizontal pleiotropy were assessed using the Cochrane’s Q test, MR-Egger intercept, and MR-PRESSO test. A sensitivity analysis was also performed. Results: MR analysis showed associations between COPD and lung cancer with increased sepsis risk (odds ratio (OR)IVW 1.138, P = 0.006; (OR)IVW 1.123, P = 0.031; respectively) and sepsis mortality ((OR)IVW 1.350, P = 0.022; (OR)IVW 1.312, P = 0.022; respectively). Asthma exhibited a potential protective effect against sepsis mortality ((OR)IVW = 0.300, P = 0.039), while PE demonstrated a risk effect ((OR)IVW = 1.148, P = 0.032). No causal association was observed between asthma, PE, and sepsis (P> 0.05). IPF and OSA were not significantly associated with sepsis or sepsis-related mortality (P> 0.05). Heterogeneity and horizontal pleiotropy were not evident for asthma or lung cancer (P> 0.05). However, horizontal pleiotropy was suggested for COPD by the MR-Egger regression (P < 0.05), but not by the MR-PRESSO test (P> 0.05). IPF and OSA were not significantly associated with sepsis or sepsis-related mortality (P> 0.05). Conclusion: Our MR analysis offers new insights into potential links between noninfectious respiratory diseases and the risk of sepsis. However, additional investigation into the underlying mechanisms and clinical studies are necessary to confirm these findings.
      PubDate: Mon, 25 Mar 2024 00:00:00 GMT-
       
 
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AACN Advanced Critical Care     Full-text available via subscription   (Followers: 38)
Academic Emergency Medicine     Hybrid Journal   (Followers: 102)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acute and Critical Care     Open Access   (Followers: 10)
Acute Cardiac Care     Hybrid Journal   (Followers: 13)
Acute Medicine     Full-text available via subscription   (Followers: 7)
Advances in Emergency Medicine     Open Access   (Followers: 22)
Advances in Neonatal Care     Hybrid Journal   (Followers: 46)
African Journal of Anaesthesia and Intensive Care     Full-text available via subscription   (Followers: 8)
African Journal of Emergency Medicine     Open Access   (Followers: 6)
American Journal of Emergency Medicine     Hybrid Journal   (Followers: 58)
Annals of Emergency Medicine     Hybrid Journal   (Followers: 179)
Annals of Intensive Care     Open Access   (Followers: 40)
Annals of the American Thoracic Society     Full-text available via subscription   (Followers: 17)
Archives of Academic Emergency Medicine     Open Access   (Followers: 7)
ASAIO Journal     Hybrid Journal   (Followers: 3)
Australian Critical Care     Full-text available via subscription   (Followers: 21)
Bangladesh Critical Care Journal     Open Access   (Followers: 1)
BMC Emergency Medicine     Open Access   (Followers: 30)
BMJ Quality & Safety     Hybrid Journal   (Followers: 67)
Burns Open     Open Access   (Followers: 1)
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine     Hybrid Journal   (Followers: 3)
Case Reports in Critical Care     Open Access   (Followers: 14)
Case Reports in Emergency Medicine     Open Access   (Followers: 23)
Chronic Wound Care Management and Research     Open Access   (Followers: 8)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 28)
Clinical Medicine Insights : Trauma and Intensive Medicine     Open Access   (Followers: 3)
Clinical Risk     Hybrid Journal   (Followers: 6)
Crisis: The Journal of Crisis Intervention and Suicide Prevention     Hybrid Journal   (Followers: 17)
Critical Care     Open Access   (Followers: 80)
Critical Care and Resuscitation     Full-text available via subscription   (Followers: 30)
Critical Care Clinics     Full-text available via subscription   (Followers: 37)
Critical Care Explorations     Open Access   (Followers: 3)
Critical Care Medicine     Hybrid Journal   (Followers: 388)
Critical Care Research and Practice     Open Access   (Followers: 13)
Current Emergency and Hospital Medicine Reports     Hybrid Journal   (Followers: 6)
Current Opinion in Critical Care     Hybrid Journal   (Followers: 74)
Disaster and Emergency Medicine Journal     Open Access   (Followers: 13)
Egyptian Journal of Critical Care Medicine     Open Access   (Followers: 2)
EMC - Urgenze     Full-text available via subscription  
Emergency Care Journal     Open Access   (Followers: 8)
Emergency Medicine (Medicina neotložnyh sostoânij)     Open Access  
Emergency Medicine Australasia     Hybrid Journal   (Followers: 19)
Emergency Medicine Clinics of North America     Full-text available via subscription   (Followers: 19)
Emergency Medicine Journal     Hybrid Journal   (Followers: 56)
Emergency Medicine News     Full-text available via subscription   (Followers: 7)
Emergency Nurse     Full-text available via subscription   (Followers: 17)
Enfermería Intensiva (English ed.)     Full-text available via subscription   (Followers: 2)
European Burn Journal     Open Access   (Followers: 7)
European Journal of Emergency Medicine     Hybrid Journal   (Followers: 25)
Hong Kong Journal of Emergency Medicine     Full-text available via subscription   (Followers: 5)
Injury     Hybrid Journal   (Followers: 23)
Intensive Care Medicine     Hybrid Journal   (Followers: 91)
Intensive Care Medicine Experimental     Open Access   (Followers: 2)
Intensivmedizin up2date     Hybrid Journal   (Followers: 4)
International Journal of Emergency Medicine     Open Access   (Followers: 10)
International Paramedic Practice     Full-text available via subscription   (Followers: 17)
Iranian Journal of Emergency Medicine     Open Access  
Irish Journal of Paramedicine     Open Access   (Followers: 3)
Journal of Acute Care Physical Therapy     Hybrid Journal   (Followers: 4)
Journal of Cardiac Critical Care TSS     Open Access   (Followers: 1)
Journal Of Cardiovascular Emergencies     Open Access  
Journal of Concussion     Open Access  
Journal of Critical Care     Hybrid Journal   (Followers: 51)
Journal of Education and Teaching in Emergency Medicine     Open Access   (Followers: 1)
Journal of Emergency Medical Services     Full-text available via subscription   (Followers: 12)
Journal of Emergency Medicine     Hybrid Journal   (Followers: 53)
Journal of Emergency Medicine, Trauma and Acute Care     Open Access   (Followers: 28)
Journal of Emergency Practice and Trauma     Open Access   (Followers: 6)
Journal of Intensive Care     Open Access   (Followers: 9)
Journal of Intensive Care Medicine     Hybrid Journal   (Followers: 24)
Journal of Intensive Medicine     Open Access   (Followers: 1)
Journal of Neuroanaesthesiology and Critical Care     Open Access   (Followers: 4)
Journal of Stroke Medicine     Hybrid Journal   (Followers: 3)
Journal of the American College of Emergency Physicians Open     Open Access   (Followers: 2)
Journal of the Intensive Care Society     Hybrid Journal   (Followers: 5)
Journal of the Royal Army Medical Corps     Hybrid Journal   (Followers: 9)
Journal of Thrombosis and Haemostasis     Hybrid Journal   (Followers: 52)
Journal of Trauma and Acute Care Surgery, The     Hybrid Journal   (Followers: 39)
La Presse Médicale Open     Open Access  
Médecine de Catastrophe - Urgences Collectives     Hybrid Journal  
Medicina Intensiva     Open Access   (Followers: 3)
Medicina Intensiva (English Edition)     Hybrid Journal   (Followers: 1)
Mediterranean Journal of Emergency Medicine & Acute Care : MedJEM     Open Access  
Notfall + Rettungsmedizin     Hybrid Journal   (Followers: 4)
Open Access Emergency Medicine     Open Access   (Followers: 6)
Open Journal of Emergency Medicine     Open Access   (Followers: 2)
Palliative Care : Research and Treatment     Open Access   (Followers: 25)
Palliative Medicine     Hybrid Journal   (Followers: 59)
Prehospital Emergency Care     Hybrid Journal   (Followers: 20)
Regulatory Toxicology and Pharmacology     Hybrid Journal   (Followers: 26)
Resuscitation     Hybrid Journal   (Followers: 60)
Resuscitation Plus     Open Access   (Followers: 2)
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine     Open Access   (Followers: 14)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 28)
Shock : Injury, Inflammation, and Sepsis : Laboratory and Clinical Approaches     Hybrid Journal   (Followers: 12)
The Journal of Trauma Injury Infection and Critical Care     Full-text available via subscription   (Followers: 24)
Therapeutics and Clinical Risk Management     Open Access   (Followers: 1)
Transplant Research and Risk Management     Open Access   (Followers: 1)
Trauma Case Reports     Open Access   (Followers: 3)
Visual Journal of Emergency Medicine     Full-text available via subscription   (Followers: 1)
Western Journal of Emergency Medicine     Open Access   (Followers: 11)
 AEM Education and Training : A Global Journal of Emergency Care     Open Access   (Followers: 1)

           

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