A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

        1 2 3 | Last   [Sort by number of followers]   [Restore default list]

  Subjects -> PHARMACY AND PHARMACOLOGY (Total: 575 journals)
Showing 1 - 200 of 253 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 27)
AAPS Open     Open Access   (Followers: 5)
AAPS PharmSciTech     Hybrid Journal   (Followers: 6)
AboutOpen     Open Access  
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
Acta Pharmaceutica     Open Access   (Followers: 4)
Acta Pharmaceutica Indonesia     Open Access  
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Pharmacologica Sinica     Hybrid Journal   (Followers: 2)
Acta Physiologica Hungarica     Full-text available via subscription  
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 4)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 90)
Advanced Herbal Medicine     Open Access   (Followers: 9)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Medical, Pharmaceutical and Dental Research     Open Access   (Followers: 5)
Advances in Pharmacoepidemiology & Drug Safety     Open Access   (Followers: 2)
Advances in Pharmacological and Pharmaceutical Sciences     Open Access   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 8)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 4)
Adverse Drug Reaction Bulletin     Full-text available via subscription   (Followers: 4)
AJP : The Australian Journal of Pharmacy     Full-text available via subscription   (Followers: 11)
Al-Azhar Journal of Pharmaceutical Sciences     Open Access   (Followers: 8)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 6)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 20)
American Journal of Drug Discovery and Development     Open Access   (Followers: 2)
American Journal of Health-System Pharmacy     Full-text available via subscription   (Followers: 51)
American Journal of Pharmacological Sciences     Open Access   (Followers: 2)
American Journal of Pharmacology and Toxicology     Open Access   (Followers: 21)
American Journal of Therapeutics     Hybrid Journal   (Followers: 11)
Analytical Methods     Hybrid Journal   (Followers: 7)
Annales Pharmaceutiques Francaises     Full-text available via subscription  
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 51)
Annual Review of Pharmacology and Toxicology     Full-text available via subscription   (Followers: 26)
Anti-Infective Agents     Hybrid Journal   (Followers: 5)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 6)
Antibiotics     Open Access   (Followers: 12)
Antibody Therapeutics     Open Access  
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Antiviral Research     Hybrid Journal   (Followers: 7)
Applied Clinical Trials     Full-text available via subscription   (Followers: 4)
Archiv der Pharmazie     Hybrid Journal   (Followers: 2)
Archives of Drug Information     Hybrid Journal   (Followers: 4)
Archives of Pharmacal Research     Full-text available via subscription   (Followers: 1)
Archives of Pharmacy and Pharmaceutical Sciences     Open Access   (Followers: 2)
Archives of Razi Institute     Open Access   (Followers: 1)
Archivos Venezolanos de Farmacología y Terapéutica     Open Access  
Ars Pharmaceutica     Open Access  
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Pharmaceutical Research and Health Care     Open Access   (Followers: 2)
Asian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Asian Journal of Pharmaceutics     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
ASSAY and Drug Development Technologies     Hybrid Journal   (Followers: 3)
Australian Journal of Herbal Medicine     Full-text available via subscription   (Followers: 4)
Australian Pharmacist     Full-text available via subscription   (Followers: 7)
Autonomic & Autacoid Pharmacology     Hybrid Journal  
Avicenna Journal of Phytomedicine     Open Access   (Followers: 1)
Bangladesh Journal of Pharmacology     Open Access  
Bangladesh Journal of Physiology and Pharmacology     Open Access  
Bangladesh Pharmaceutical Journal     Full-text available via subscription  
Basic & Clinical Pharmacology & Toxicology     Hybrid Journal   (Followers: 11)
Behavioural Pharmacology     Hybrid Journal   (Followers: 2)
Bioanalysis     Full-text available via subscription   (Followers: 6)
Biochemical Pharmacology     Hybrid Journal   (Followers: 9)
BioDrugs     Full-text available via subscription   (Followers: 4)
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1)
Biomarkers in Drug Development     Partially Free   (Followers: 1)
Biomaterials     Hybrid Journal   (Followers: 54)
Biomedical and Environmental Sciences     Full-text available via subscription   (Followers: 1)
Biomedicine & Pharmacotherapy     Full-text available via subscription   (Followers: 2)
Biometrical Journal     Hybrid Journal   (Followers: 6)
Biopharm International     Full-text available via subscription   (Followers: 8)
Biopharmaceutics and Drug Disposition     Hybrid Journal   (Followers: 11)
BMC Pharmacology     Open Access   (Followers: 3)
BMC Pharmacology & Toxicology     Open Access   (Followers: 5)
Brazilian Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
British Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 25)
British Journal of Pharmacology     Hybrid Journal   (Followers: 14)
British Journal of Pharmacy (BJPharm)     Open Access   (Followers: 2)
Bulletin of Faculty of Pharmacy, Cairo University     Open Access   (Followers: 2)
CADTH Technology Overviews     Free  
Canadian Journal of Pain     Open Access   (Followers: 3)
Canadian Journal of Physiology and Pharmacology     Hybrid Journal   (Followers: 1)
Canadian Pharmacists Journal / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3)
Cancer Biotherapy & Radiopharmaceuticals     Hybrid Journal  
Cancer Chemotherapy and Pharmacology     Hybrid Journal   (Followers: 4)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 12)
Cardiovascular Therapeutics     Open Access   (Followers: 3)
Cephalalgia Reports     Open Access  
Chemical and Pharmaceutical Bulletin     Full-text available via subscription  
Chemical Research in Toxicology     Hybrid Journal   (Followers: 20)
ChemMedChem     Hybrid Journal   (Followers: 9)
Chemotherapy     Full-text available via subscription   (Followers: 3)
Chinese Herbal Medicines     Full-text available via subscription   (Followers: 1)
Chinese Journal of Pharmaceutical Analysis     Full-text available via subscription  
Ciencia e Investigación     Open Access  
Ciência Equatorial     Open Access  
Clinical and Experimental Pharmacology and Physiology     Hybrid Journal   (Followers: 3)
Clinical and Translational Science     Open Access   (Followers: 4)
Clinical Complementary Medicine and Pharmacology     Open Access   (Followers: 3)
Clinical Drug Investigation     Full-text available via subscription   (Followers: 6)
Clinical Medicine Insights : Therapeutics     Open Access  
Clinical Neuropharmacology     Hybrid Journal   (Followers: 2)
Clinical Pharmacist     Partially Free   (Followers: 11)
Clinical Pharmacokinetics     Full-text available via subscription   (Followers: 16)
Clinical Pharmacology & Therapeutics     Hybrid Journal   (Followers: 31)
Clinical Pharmacology in Drug Development     Hybrid Journal   (Followers: 2)
Clinical Pharmacology: Advances and Applications     Open Access   (Followers: 5)
Clinical Research and Regulatory Affairs     Hybrid Journal   (Followers: 5)
Clinical Therapeutics     Hybrid Journal   (Followers: 10)
Clinical Toxicology     Hybrid Journal   (Followers: 17)
Clinical Trials     Hybrid Journal   (Followers: 11)
CNS Drug Reviews     Open Access   (Followers: 3)
CNS Drugs     Full-text available via subscription   (Followers: 10)
Combination Products in Therapy     Open Access  
Consultant Pharmacist     Full-text available via subscription   (Followers: 2)
Consumer Drugs     Full-text available via subscription  
Contract Pharma     Full-text available via subscription  
Cosmetics     Open Access   (Followers: 4)
CPT : Pharmacometrics & Systems Pharmacology     Open Access   (Followers: 6)
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Critical Reviews in Therapeutic Drug Carrier Systems     Full-text available via subscription  
Critical Reviews in Toxicology     Hybrid Journal   (Followers: 22)
Current Bioactive Compounds     Hybrid Journal  
Current Cancer Therapy Reviews     Hybrid Journal   (Followers: 5)
Current Clinical Pharmacology     Hybrid Journal   (Followers: 3)
Current Drug Delivery     Hybrid Journal   (Followers: 6)
Current Drug Discovery Technologies     Hybrid Journal   (Followers: 5)
Current Drug Metabolism     Hybrid Journal   (Followers: 3)
Current Drug Safety     Hybrid Journal   (Followers: 8)
Current Drug Targets     Hybrid Journal   (Followers: 2)
Current Drug Therapy     Hybrid Journal   (Followers: 2)
Current Enzyme Inhibition     Hybrid Journal   (Followers: 1)
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 2)
Current Medical Science     Hybrid Journal  
Current Medicinal Chemistry     Hybrid Journal   (Followers: 7)
Current Molecular Pharmacology     Hybrid Journal  
Current Nanoscience     Hybrid Journal  
Current Neuropharmacology     Hybrid Journal   (Followers: 1)
Current Opinion in Pharmacology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Analysis     Hybrid Journal   (Followers: 1)
Current Pharmaceutical Biotechnology     Hybrid Journal   (Followers: 8)
Current Pharmaceutical Design     Hybrid Journal   (Followers: 4)
Current Pharmacogenomics and Personalized Medicine     Hybrid Journal   (Followers: 3)
Current Pharmacology Reports     Hybrid Journal  
Current Protocols in Pharmacology     Hybrid Journal  
Current Radiopharmaceuticals     Hybrid Journal   (Followers: 1)
Current Research in Drug Discovery     Open Access   (Followers: 1)
Current Research in Pharmacology and Drug Discovery     Open Access   (Followers: 6)
Current Therapeutic Research     Open Access   (Followers: 5)
Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 7)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 1)
Dhaka University Journal of Pharmaceutical Sciences     Open Access  
Die Pharmazie - An International Journal of Pharmaceutical Sciences     Full-text available via subscription   (Followers: 3)
Dose-Response     Open Access  
Drug and Chemical Toxicology     Hybrid Journal   (Followers: 12)
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 8)
Drug Delivery     Open Access   (Followers: 7)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Design, Development and Therapy     Open Access   (Followers: 1)
Drug Development and Industrial Pharmacy     Hybrid Journal   (Followers: 24)
Drug Development Research     Hybrid Journal   (Followers: 8)
Drug Discovery Today: Technologies     Full-text available via subscription   (Followers: 7)
Drug Metabolism and Disposition     Hybrid Journal   (Followers: 8)
Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 3)
Drug Metabolism Letters     Hybrid Journal   (Followers: 2)
Drug Metabolism Reviews     Hybrid Journal   (Followers: 3)
Drug Research     Hybrid Journal   (Followers: 1)
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Drug Safety     Full-text available via subscription   (Followers: 78)
Drug Safety - Case Reports     Open Access   (Followers: 2)
Drug Target Insights     Open Access  
Drug, Healthcare and Patient Safety     Open Access   (Followers: 8)
Drugs     Full-text available via subscription   (Followers: 139)
Drugs & Aging     Full-text available via subscription   (Followers: 9)
Drugs & Therapy Perspectives     Full-text available via subscription   (Followers: 9)
Drugs : Real World Outcomes     Hybrid Journal   (Followers: 1)
Drugs and Therapy Studies     Open Access  
Drugs in R & D     Full-text available via subscription   (Followers: 2)
Drugs of the Future     Full-text available via subscription   (Followers: 4)
East and Central African Journal of Pharmaceutical Sciences     Open Access   (Followers: 1)
Egyptian Pharmaceutical Journal     Open Access  
EJNMMI Radiopharmacy and Chemistry     Open Access  
EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei     Full-text available via subscription  
Emerging Trends in Drugs, Addictions, and Health     Open Access   (Followers: 1)
Environmental Toxicology and Pharmacology     Hybrid Journal   (Followers: 7)
Epilepsy Research     Hybrid Journal   (Followers: 8)
Ethiopian Pharmaceutical Journal     Full-text available via subscription   (Followers: 1)
EUREKA : Health Sciences     Open Access  
European Journal of Clinical Pharmacology     Hybrid Journal   (Followers: 11)
European Journal of Drug Metabolism and Pharmacokinetics     Hybrid Journal   (Followers: 5)
European Journal of Hospital Pharmacy : Science and Practice (EJHP)     Hybrid Journal   (Followers: 5)
European Journal of Medicinal Plants     Open Access   (Followers: 2)
European Journal of Pharmaceutical Sciences     Hybrid Journal   (Followers: 82)
European Journal of Pharmaceutics and Biopharmaceutics     Hybrid Journal   (Followers: 23)
European Journal of Pharmacology     Hybrid Journal   (Followers: 3)
European Medical, Health and Pharmaceutical Journal     Open Access   (Followers: 2)
European Neuropsychopharmacology     Hybrid Journal   (Followers: 8)
European Pharmaceutical Journal     Open Access  

        1 2 3 | Last   [Sort by number of followers]   [Restore default list]

Similar Journals
Journal Cover
Al-Azhar Journal of Pharmaceutical Sciences
Number of Followers: 8  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1110-1644 - ISSN (Online) 2535-1958
Published by Al-Azhar University Homepage  [6 journals]

    • Abstract: Nanosuspensions (NS) are novel means of delivering drugs in controlled manner used to enhance bioavailability and get controlled therapeutic effect. Thus, the aim of the current study was to develop and optimize the preparation and characterization methods of Nanosuspensions for poorly water-soluble drug compound Rosuvastatin Ca (ROS) using Box Behnken Design (BBD). Pre formulation studies included differential scanning Calorimetry (DSC), Infra-Red (FTIR) spectroscopy and X-Ray diffraction (XRD) analysis were carried out to check compatibility of ROS and other excipient before starting optimization modeling by Box Behnken Design. The designed fifteen formulae of Nanosuspension were prepared and monitored for different responses to determine optimum formula and its expected characterization parameters. Then testing the efficiency of optimum formula against selected responses. Rosuvastatin Ca (ROS) nano suspension formulating was prepared using thin film hydration method using Box Behnken Design modeling include three independent variables (cholesterol (X1), Soy lecithin (X2), and span 60 (X3)), The responses were coded Y1 to Y6 respectively (particle size (PS), zeta potential (ZP), entrapment efficiency percent (EE%), as well as in vitro drug release after four hours, eight hours, and twelve hours. After obtaining optimum formula it was monitored for responses Y1 to Y6. The values of studied responses were particle size (408.6 nm), zeta potential (-53 mv), entrapment efficiency (79.2 %), cumulative drug release at 4 hr (53.2 %), cumulative drug release at 8 hr (67.1 %) and cumulative drug release at 12 hr (86.8 %). The results demonstrated that BBD optimization technique succeeded in prediction of an optimized ROS NS formula which when prepared and investigated, it met the demands of the desired responses comparing with free Rosuvastatin.

    • Abstract: Voriconazole is a triazole antifungal with a half-life of 1.7 hours and 96% oral bioavailability. The oral route is the most popular of drug delivery routes. However, there are a few limitations to the traditional dosage form, for instance, fluctuations in plasma drug level.  Sustained drug delivery system overcomes these limitations; it helps to maintain stable plasma drug concentrations by decreasing drug r elease and extending the duration of the effect. The main purpose of this study was to formulate voriconazole sustained release dosage form to enhance efficacy, decrease dose frequency, decrease its side effects, and improve patient compliance. The study explored various formulations for producing the sustained-release (S.R) dosage form, as well as assessed the drug's release kinetics and its stability. Methodology: Fourier-transform Infrared Spectroscopy was used to investigate drug-polymer compatibility. The micromeritics of voriconazole powder and its blends were evaluated. Different sustained release tablets were formulated utilizing a wet granulation process and acrylic polymers (Eudragit) i.e., Eudragit RL100 and RS100 alone and as mixtures with different ratios, in different concentrations. In-vitro drug release of formulae was performed for 24 hours. The formula with desired control of drug release and complied with dissolution specifications for SR dosage forms was further evaluated for its stability by storage for 3 months at 30o C and 40o C and 75% relative humidity. Results: no interaction was observed between voriconazole and polymers using FTIR. The powder blends micromeritics were found to be in accordance with the specification. Tablets showed release from 37.29 to 76 % up to 24 hr using USP type I technique. It was found that as polymer concentration increased, the drug release from tablet decreased. The selected formulation F13 which containing 5% of Eudragit RL100:RS100 at a ratio of (10:1) was found to be stable.  Conclusion: The obtained data concluded that the F13 formula gave more prominent S.R effect than using Eudragit RL100 or RS 100 alone.

    • Abstract: Cancer is a disease in which human cells grow uncontrollably and spread to other body parts. Cancer is the second leading cause of death globally and accounted for 9.6 million deaths in 2022 according to the statistics of the World Health Organization. Cancer can begin in any part of the human organs when the normal cell loses the ability to control the division cycle, which may inhibit apoptosis. Cancer cells grow and multiply by activating the angiogenetic factors to build new capillaries that can supply tumor tissue with nutrients. Cancerous tumors spread into or invade nearby tissues and can travel to other organs in the body to form new carcinogenic tissue by metastasis. The goal of treatment is control growth of cancer cells, and induction the programmed cell death. Pyrimidines and its derivatives have been found as effective and valuable pharmacophoric units in medicinal chemistry to design and develop a wide range of bioactive compounds. The present review summarizes the advances in lead compounds of pyrimidines hybrids and their related heterocycles in the treatment of cancer. Moreover, the review also helps to intensify the drug development process by providing an understanding of the potential role of these hybridized pharmacophoric features as VEGFR-2 inhibitors. Abbreviations Abbreviation Meaning FGFR1  Fibroblast growth factor receptor 1 VEGFR  Vascular Endothelial Growth Factor CSF-1R Colony stimulating factor 1 receptor NETs Neuroendocrine tumors AKT  Protein kinase B (PKB), also known as Akt A549  Human lung adenocarcinoma cell line MCF-7 Human breast cancer cell line HepG2 Human liver cancer cell line Ovcar-3 High-grade serous ovarian adenocarcinoma cell line Objectives                         The aim of this study is to highlight the role of Pyrimidines containing compounds in inhibiting VEGFR-2 as well as to suggest some new aspects of treatment of cancer using pyrimidines scaffold soon.

    • Abstract: Cancer is a global health challenge; it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents. Pyrimidine, a privileged scaffold, is part of living organisms and plays vital role in various biological procedures as well as in cancer pathogenesis. Due to resemblance in structure with the nucleotide base pair of DNA and RNA, it is recognized as valuable compound in the treatment of cancer. Objectives Many novel pyrimidine derivatives have been designed and developed for their anticancer activity in the last few years. The present review aims to focus on the structure of pyrimidine derivatives as anticancer agent from the last decade. Results In summary, the development of more potent and efficacious anticancer drugs with pyrimidine scaffold will continue to be a promising scaffold over the next 20 years.

    • Abstract: Human phosphatidyl inositol mannoside kinases (Pim kinases) are important biological target for discovery of new anticancer agents. In addition, Pyrimidines have a good contribution as building blocks of many anticancer agents. Hence, a literature survey about Pim kinases inhibitors and pyrimidine-based anticancer agents have been achieved. In this survey, we introduced Pim kinase inhibitors under clinical assessment including imidazo[1,2-b]pyridazines, isatins, thiazolidine-2,4-diones, pyridinamines, and diaminopyrazoles. In addition, Pim kinase inhibitors under development were presented. These compounds include pyridine-quinolines, benzimidazoles indoles, cyano pyridines, pyridothieno[3,2-d]pyrimidin-4-ones, oxadiazole, and 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones. Furthermore, different pyrimidine-based anticancer agents have been discussed.

    • Abstract: Development and validation of three simple, eco-friendly, accurate and precise chemometric models have been presented for the spectrophotometric determination of ciprofloxacin (CIP), indomethacin (IND), and metronidazole (MET) residues in production wastewater samples. These methods are classical least square (CLS), principal component regression (PCR) and partial least square (PLS-1). A 3-factor 5-level experimental design was built leading to 25 mixtures containing different ratios of CIP, MET, and IND. Thirteen mixtures were used as a training set, and the other twelve were used as a validation set. Using of multi-wavelengths instead of the single wavelength spectrophotometry has greatly improved the precision and predictive abilities of these multivariate calibrations. The proposed methods have been found to be accurate, precise and can be used for determination of the drugs in pure form and industrial wastewater samples without preliminary separation steps. The methods described were used to accurately assess the drug residues in laboratory-prepared mixtures and actual industrial wastewater samples to confirm that it is free from these drug residues so it can be recycled and used for irrigation and other purposes.

    • Abstract: Three simple, accurate and precise multivariate calibration models, including classical least square (CLS), principal component regression (PCR) and partial least square (PLS-1), have been used for simultaneous determination of the components of recently approved fixed – dose combination tablet containing amlodipine / candesartan mixture in their pure forms and their pharmaceutical preparations, using spectral data in the range of (220nm-400nm). The CLS, PCR and PLS-1 models are useful in spectral analysis because the simultaneous employment of many spectral wavelengths instead of the single wavelength used in derivative spectrophotometry, which greatly improves the precision and predictive abilities of these multivariate calibrations. The developed methods were statistically compared with the reported spectrophotometric method and no significant differences were observed regarding both accuracy and precision, all the developed methods have been validated using external validation set. Moreover, the proposed models were successfully applied to the spectrophotometric determination of amolodipine besylate and candesartane cilexetil in Unisia® tablets.

    • Abstract: Four simple, fast, accurate, reproducible, and non-sophisticated spectrophotometric methods were developed and validated for the simultaneous determination of chlorzoxazone and diclofenac potassium without preliminary separation in pure powder form and in their capsule formulation. Method A, is a dual wavelength spectrophotometric method in which the wavelengths selected for determination of chlorzoxazone were 259 nm and 294 nm, whereas the wavelengths selected for determination of diclofenac potassium were 294 nm and 242 nm. while method B, is a ratio difference spectrophotometric method in which the wavelengths selected for determination of chlorzoxazone were 280 nm and 230 nm, whereas the wavelengths selected for determination of diclofenac potassium were 246 nm and 284 nm. while method C, is the first derivative of the ratio spectra measured at 290 nm and 301 nm for chlorzoxazone and diclofenac potassium, respectively. While method D, is the constant center spectrophotometric method in which more measured at 280 nm and 277 nm for chlorzoxazone and diclofenac potassium, respectively. Regression analysis of Beer-Lambert’s plots showed good correlation in concentration range of 2.5 – 20 μg/mL for both drugs with LOD 0.308 μg/mL and 0.932 μg/mL, LOQ 0.458 μg/mL and 1.388 μg/mL, RSD 1.325 and 1.666 and % recovery 98.99 and 101.23 for chlorzoxazone and diclofenac potassium, respectively in method A. Furthermore, LOD 0.307 μg/mL and 0.373 μg/mL, LOQ 0.929 μg/mL and 1.123 μg/mL, RSD 1.065 and 1.371 and % recovery 99.94 and 101.53 for chlorzoxazone and diclofenac potassium, respectively in method B. Furthermore, LOD 0.287 μg/mL and 0.301 μg/mL, LOQ 0.871 μg/mL and 0.911 μg/mL, RSD 1.214 and 1.596 and % recovery 99.73 and 100.26 for chlorzoxazone and diclofenac potassium, respectively in method C. Furthermore, LOD 0.221 μg/mL and 0.331 μg/mL, LOQ 0.521 μg/mL and 0.825 μg/mL, RSD 0.914 and 1.412 and % recovery 101.22 and 98.59 for chlorzoxazone and diclofenac potassium, respectively in method D. The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for determination of chlorzoxazone and diclofenac potassium in their laboratory prepared mixtures and commercial capsule formulation.

    • Abstract: The aim of this study was to investigate the common dermatophytosis and dermatophyte(s) in Cairo hospitals, examining age, gender, blood groups, and dermatophyte incidence. It explores natural extracts like plant oils and fungal extracts as alternatives to commercial antifungal drugs and their synergistic effects. In this study, the prevalence of distinct types of dermatophytosis was investigated in 128 patients who were referred to the dermatology departments of different hospitals, including EL-Houd El-Marsoud, El Zahraa Medical Hospital, and El-Sahel Teaching Hospital in Cairo, Egypt. Descriptive data for the tested patients was collected, including age, gender, the source of infection, and blood group type. The results showed that Tinea capitis was the most prevalent dermatophytosis, mostly in children. Investigating the correlation between blood group types and the incidence of the disease revealed that patients with blood groups B and O were the most sensitive ones. The most prevalent dermatophyte within the studied cases was identified and submitted to GenBank as Microsporum canis ON564613. To investigate the effectiveness of antifungal agents against M. canis, different common antifungal drugs, including terbinafine, ketoconazole, clotrimazole, fluconazole, and betadine, were evaluated using the agar disc diffusion test. In addition, natural alternatives were used including essential oils and an ethanolic fungal extract from Fusarium chlamydosporium. The minimum inhibitory concentration (MIC) of the potent agents was detected, including terbinafine, ketoconazole, clotrimazole, clove oil, and F. chlamydosporium extract. The effective antifungal agents against M. canis were clove oil and F. chlamydosporium extract, as well as commercial drugs. According to the MIC, a synergy between combinations of different concentrations of clove oil with terbinafine, ketoconazole, and the F. chlamydosporium extract showed a synergetic effect. These results show the promising potency of these combinations in disease control compared to their use individually.

    • Abstract: Depending to the WHO, antibiotic resistance and limited anticancer and antimicrobial therapies continue to be serious worldwide health challenges. Current medicines' efficacy suffers by issues such as insufficient solubility, stability, and side effects. To create effective and dependable therapies against antibiotic resistance and robust illnesses, new techniques and strategies are required. Several metal nanoparticles synthesised via green synthesis or chemical synthesise, such as gold (Au), zine (ZnO), and others, have shown promising biological effects against malignancies and a wide spectrum of microbial illnesses caused by multi-drug resistant bacteria. An eco-friendly biosynthetic technique was used to create zinc oxide nanoparticles (ZnO NPs), as well as their antibacterial and anticarcinogenic activities. Extracellular synthesis of nanoparticles made of zinc oxide ZnO nanoparticles was achieved in the current work using the cell filtrate of the endophytic fungus Fusarium chlamydosporum MW341592.1 isolated from healthy leaves of Eucalyptus sideroxylon plant. The nanoparticles were characterised by UV-VIS spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), transition electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX). The UV-Vis absorption spectra of the produced ZnO NPs showed bands in the UV area at (305) nm. Transmission electron microscopy TEM revealed average sizes of 19.3 nm, while shape revealed spherical like shape. The distinctive pattern of crystalline ZnO NPs was revealed by XRD diffract grams. Furthermore, Biological assay has shown that raising the nanoparticle concentration lowers the number of HCT-116 human colon cancer cells and CACO2 human intestinal cancer cells, as well as antibacterial pathogens Escherichia coli and Pseudomonas aeruginosa.
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762

Your IP address:
Home (Search)
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-